1. Low-Dose 4D-STEM tomography for beam-sensitive nanocomposites
- Author
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Hugenschmidt, M. (Milena), Jannis, D. (Daen), Kadu, A.A. (Ajinkya), Grünewald, L. (Lukas), De Marchi, S. (Sarah), Pérez-Juste, J. (Jorge), Verbeeck, J. (Johan), Van Aert, S. (Sandra), Bals, S. (Sara), Hugenschmidt, M. (Milena), Jannis, D. (Daen), Kadu, A.A. (Ajinkya), Grünewald, L. (Lukas), De Marchi, S. (Sarah), Pérez-Juste, J. (Jorge), Verbeeck, J. (Johan), Van Aert, S. (Sandra), and Bals, S. (Sara)
- Abstract
Electron tomography is essential for investigating the three-dimensional (3D) structure of nanomaterials. However, many of these materials, such as metal-organic frameworks (MOFs), are extremely sensitive to electron radiation, making it difficult to acquire a series of projection images for electron tomography without inducing electron-beam damage. Another significant challenge is the high contrast in high-angle annular dark field scanning transmission electron microscopy that can be expected for nanocomposites composed of a metal nanoparticle and an MOF. This strong contrast leads to so-called metal artifacts in the 3D reconstruction. To overcome these limitations, we here present low-dose electron tomography based on four-dimensional scanning transmission electron microscopy (4D-STEM) data sets, collected using an ultrafast and highly sensitive direct electron detector. As a proof of concept, we demonstrate the applicability of the method for an Au nanostar embedded in a ZIF-8 MOF, which is of great interest for applications in various fields, including drug delivery.
- Published
- 2023
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