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4. Pharmacological interventions for chronic pain in children: an overview of systematic reviews

Author

Eccleston, Christopher, Fisher, Emma, Cooper, Tess E., Grégoire, Marie-Claude, Heathcote, Lauren C., Krane, Elliot, Lord, Susan M., Sethna, Navil F., Anderson, Anna-Karenia, Anderson, Brian, Clinch, Jacqueline, Gray, Andrew L., Gold, Jeffrey I., Howard, Richard F., Ljungman, Gustaf, Moore, R. Andrew, Schechter, Neil, Wiffen, Philip J., Wilkinson, Nick M.R., Williams, David G., Wood, Chantal, van Tilburg, Miranda A.L., and Zernikow, Boris

Published
2019
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17. Optimising the process for conducting scoping reviews

Author

Pawliuk, Colleen, Brown, Helen L., Widger, Kimberley, Dewan, Tammie, Hermansen, Anne-Mette, Grégoire, Marie-Claude, Steele, Rose, and Siden, Harold

Abstract

Knowledge synthesis constitutes a key part of evidence-based medicine and a scoping review is a type of knowledge synthesis that maps the breadth of literature on a topic. Conducting a scoping review is resource-intensive and, as a result, it can be challenging to maintain best practises throughout the process. Much of the current guidance describes a scoping review framework or broad ways to conduct a scoping review. However, little detailed guidance exists on how to complete each stage to optimise the process. We present five recommendations based on our experience when conducting a particularly challenging scoping review: 1) Engage the expertise of a librarian throughout the process, 2) Conduct a truly systematic search, 3) Facilitate communication and collaboration, 4) Explore new tools or repurpose old ones, and 5) Test every stage of the process. These recommendations add to the literature by providing specific and detailed advice on each stage of a scoping review. Our intent is for these recommendations to aid other teams that are undertaking knowledge synthesis projects.

Published
2020
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19. Optimising the process for conducting scoping reviews

Author

Pawliuk, Colleen, primary, Brown, Helen L, additional, Widger, Kim, additional, Dewan, Tammie, additional, Hermansen, Anne-Mette, additional, Grégoire, Marie-Claude, additional, Steele, Rose, additional, and Siden, Harold (Hal), additional

Published
2020
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28. Neuroanatomical Correlates of Visually Evoked Sexual Arousal in Human Males

Author

Stoléru, Serge, Grégoire, Marie-Claude, Gérard, Daniel, Decety, Jean, Lafarge, Emmanuelle, Cinotti, Luc, Lavenne, Frank, Bars, Didier Le, Vernet-Maury, Evelyne, Rada, Hiram, Collet, Christian, Mazoyer, Bernard, Forest, Maguelone G., Magnin, Françoise, Spira, Alfred, and Comar, Dominique

Published
1999

37. Development and Implementation of a Survey to Assess Health-Care Provider’s Competency, Attitudes, and Knowledge About Perinatal Palliative Care

Author

Stenekes, Simone, primary, Penner, Jamie L., additional, Harlos, Michael, additional, Proulx, Marie-Claude, additional, Shepherd, Erin, additional, Liben, Stephen, additional, Thompson, Genevieve, additional, MacConnell, Grace, additional, Grégoire, Marie-Claude, additional, and Siden, Harold (Hal), additional

Published
2018
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39. Opioids for cancer-related pain in children and adolescents

Author

Wiffen, Philip J, Cooper, Tess E, Anderson, Anna-Karenia, Gray, Andrew L, Grégoire, Marie-Claude, Ljungman, Gustaf, Zernikow, Boris, Wiffen, Philip J, Cooper, Tess E, Anderson, Anna-Karenia, Gray, Andrew L, Grégoire, Marie-Claude, Ljungman, Gustaf, and Zernikow, Boris

Abstract

BACKGROUND: Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization (WHO) guidelines for pharmacological treatments for children's persisting pain acknowledge that pain in children is a major public health concern of high significance in most parts of the world. Views on children's pain have changed over time and relief of pain is now seen as important. In the past, pain was largely dismissed and was frequently left untreated, and it was assumed that children quickly forgot about painful experiences.We designed a suite of seven reviews in chronic non-cancer pain and cancer pain (looking at antidepressants, antiepileptic drugs, non-steroidal anti-inflammatory drugs, opioids, and paracetamol) to review the evidence for children's pain using pharmacological interventions.As one of the leading causes of mortality and morbidity for children and adolescents in the world today, childhood cancer (and its associated pain) is a major health concern. Cancer pain in infants, children, and adolescents is primarily nociceptive pain with negative long term effects. Cancer-related pain is generally caused directly by the tumour itself such as compressing on the nerve or inflammation of the organs. Cancer-related pain generally occurs as a result of perioperative procedures, nerve damage caused by radiation or chemotherapy treatments, or mucositis. However, this review focused on pain caused directly by the tumour itself such as nerve infiltration, external nerve compression, and other inflammatory events.Opioids are used worldwide for the treatment of pain. Currently available opioids include: buprenorphine, codeine, fentanyl, hydromorphone, methadone, morphine, oxycodone, and tramadol. Opioids are generally available in healthcare settings across most developed countries but access may be restricted in developing countries. To achieve adequate pain relief in children using opioids, with

Published
2017
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40. Non-steroidal anti-inflammatory drugs (NSAIDs) for cancer-related pain in children and adolescents

Author

Cooper, Tess E, Heathcote, Lauren C, Anderson, Brian, Grégoire, Marie-Claude, Ljungman, Gustaf, Eccleston, Christopher, Cooper, Tess E, Heathcote, Lauren C, Anderson, Brian, Grégoire, Marie-Claude, Ljungman, Gustaf, and Eccleston, Christopher

Abstract

BACKGROUND: Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization (WHO) guidelines for pharmacological treatments for persisting pain in children acknowledge that pain in children is a major public health concern of high significance in most parts of the world. Views on children's pain have changed over time and relief of pain is now seen as important. In the past, pain was largely dismissed and was frequently left untreated, and it was assumed that children quickly forgot about painful experiences.We designed a suite of seven reviews in chronic non-cancer pain and cancer pain (looking at antidepressants, antiepileptic drugs, non-steroidal anti-inflammatory drugs, opioids, and paracetamol as priority areas) to review the evidence for children's pain using pharmacological interventions.As one of the leading causes of mortality and morbidity for children and adolescents in the world today, childhood cancer (and its associated pain) is a major health concern. Specific mortality and morbidity data relating to children are not currently identified. All childhood cancer rates are on the rise; for example, in the USA approximately 10,380 children aged under 15 years were expected to be diagnosed with cancer by the end of 2016. However, with survival rates also increasing, over 80% of paediatric cancer patients are expected to survive for five years or more, thus identifying the need to address pain management in this population.Cancer pain in infants, children, and adolescents is primarily nociceptive pain with negative long term effects. Cancer-related pain is generally caused directly by the tumour itself such as compressing on the nerve or inflammation of the organs. Cancer-related pain generally occurs as a result of perioperative procedures, nerve damage caused by radiation or chemotherapy treatments, or mucositis. However, this review focused on pain caused directly by th

Published
2017
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44. Scoping review of symptoms in children with rare, progressive, life-threatening disorders

Author

Pawliuk, Colleen, Widger, Kim, Dewan, Tammie, Brander, Gina, Brown, Helen L, Hermansen, Anne-Mette, Grégoire, Marie-Claude, Steele, Rose, and Siden, Harold (Hal)

Abstract

BackgroundQ3 conditions are progressive, metabolic, neurological or chromosomal childhood conditions without a cure. Children with these conditions face an unknown lifespan as well as unstable and uncomfortable symptoms. Clinicians and other healthcare professionals are challenged by a lack of evidence for symptom management for these conditions.AimsIn this scoping review, we systematically identified and mapped the existing literature on symptom management for children with Q3 conditions. We focused on the most common and distressing symptoms, namely alertness, behavioural problems, bowel incontinence, breathing difficulties, constipation, feeding difficulties, sleep disturbance, temperature regulation, tone and motor problems and urinary incontinence. For children with complex health conditions, good symptom management is pertinent to ensure the highest possible quality of life.MethodsScoping review. Electronic database searches in Ovid MEDLINE, Embase and CINAHL and a comprehensive grey literature search.ResultsWe included 292 studies in our final synthesis. The most commonly reported conditions in the studies were Rett syndrome (n=69), followed by Cornelia de Lange syndrome (n=25) and tuberous sclerosis (n=16). Tone and motor problems were the most commonly investigated symptom (n=141), followed by behavioural problems (n=82) and sleep disturbance (n=62).ConclusionThe evidence for symptom management in Q3 conditions is concentrated around a few conditions, and these studies may not be applicable to other conditions. The evidence is dispersed in the literature and difficult to access, which further challenges healthcare providers. More research needs to be done in these conditions to provide high-quality evidence for the care of these children.

Published
2020
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45. Development and Implementation of a Survey to Assess Health-Care Provider's Competency, Attitudes, and Knowledge About Perinatal Palliative Care.

Author

Stenekes, Simone, Penner, Jamie L., Harlos, Michael, Proulx, Marie-Claude, Shepherd, Erin, Liben, Stephen, Thompson, Genevieve, MacConnell, Grace, Grégoire, Marie-Claude, and Siden, Harold (Hal)

Subjects
HEALTH attitudes, PALLIATIVE treatment, QUESTIONNAIRES
Abstract

Perinatal palliative care is an emerging area of health care. To date, no published tools assess health-care provider's knowledge and level of comfort in providing such care. A 2-phase study was undertaken to develop and implement a survey to evaluate the self-assessed competency, attitudes, and knowledge of health-care providers working in perinatal palliative care. Phase 1 included a review of the literature and appraisal of palliative and death-related instruments to inform the initial draft of the Perinatal Palliative Care Survey (PPCS). Twenty-four Canadian pediatric palliative care specialists critiqued the PPCS, establishing its face and content validity. Phase 2 involved administering the PPCS at 4 sites across Canada, resulting in 167 responses from nurses, physicians, and midwives. The majority of participants responded that they possessed a degree of comfort in providing perinatal palliative care, particularly with assessing pain (76%), managing pain (69%), assessing other symptoms (85%), and managing other symptoms (78%). Two areas where participants level of confidence or extreme confidence was diminished included having conversations with families about the possibility of their infant dying (55%) and knowing and accessing community palliative care resources (32%). Responses in the knowledge section identified gaps related to opioid use, pharmacological interventions for breathlessness, pain behaviors, and tolerance developed to opioids and sedatives. Eighty-six percent of respondents stated that if education about palliative care was made available, they would participate with priority topics identified as communication with families (75%), managing symptoms (69%), pain management (69%), and ethical issues (66%). The PPCS provides a useful assessment to determine the educational needs of health-care providers delivering perinatal palliative care. [ABSTRACT FROM AUTHOR]

Published
2019
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46. Simultaneous scanning of two mice in a small-animal PET scanner: a simulation-based assessment of the signal degradation

Author

Reilhac, Anthonin, primary, Boisson, Frédéric, additional, Wimberley, Catriona, additional, Parmar, Arvind, additional, Zahra, David, additional, Hamze, Hasar, additional, Davis, Emma, additional, Arthur, Andrew, additional, Bouillot, Caroline, additional, Charil, Arnaud, additional, and Grégoire, Marie-Claude, additional

Published
2016
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47. Book Review

Author

Grégoire, Marie-Claude

Subjects
Book Review
Published
2013

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