29 results on '"Grèze, Victoria"'
Search Results
2. Unleashing the power of NK cells in anticancer immunotherapy
- Author
-
Vogler, Meike, Shanmugalingam, Senthan, Särchen, Vinzenz, Reindl, Lisa Marie, Grèze, Victoria, Buchinger, Leon, Kühn, Michael, and Ullrich, Evelyn
- Published
- 2022
- Full Text
- View/download PDF
3. Faster clinical decisions in B‐cell acute lymphoblastic leukaemia: A single flow cytometric 12‐colour tube improves diagnosis and minimal residual disease follow‐up
- Author
-
Lebecque, Benjamin, primary, Besombes, Joevin, additional, Dannus, Louis‐Thomas, additional, De Antonio, Marie, additional, Cacheux, Victoria, additional, Grèze, Victoria, additional, Montagnon, Valentin, additional, Veronese, Lauren, additional, Tchirkov, Andrei, additional, Tournilhac, Olivier, additional, Berger, Marc G., additional, and Veyrat‐Masson, Richard, additional
- Published
- 2024
- Full Text
- View/download PDF
4. Accès à la préservation de la fertilité des adolescents et jeunes adultes de 15 à 24 ans atteints de cancers en Auvergne, France
- Author
-
Grèze, Victoria, Mechdoud, Sabrina, Vorilhon, Solène, Isfan, Florentina, Rouel, Nadège, Chaput, Laure, Brugnon, Florence, and Kanold, Justyna
- Published
- 2020
- Full Text
- View/download PDF
5. Assessment of the architecture and integrity of frozen‐thawed testicular tissue from (pre)pubertal boys with cancer
- Author
-
Rives‐Feraille, Aurélie, primary, Liard, Agnès, additional, Bubenheim, Michael, additional, Barbotin, Anne Laure, additional, Giscard d'Estaing, Sandrine, additional, Mirallié, Sophie, additional, Ancelle, Amélie, additional, Roux, Christophe, additional, Brugnon, Florence, additional, Grèze, Victoria, additional, Daudin, Myriam, additional, Willson‐Plat, Geneviève, additional, Dubois, Rémi, additional, Sibert, Louis, additional, Schneider, Pascale, additional, and Rives, Nathalie, additional
- Published
- 2021
- Full Text
- View/download PDF
6. Characterization and manipulation of the crosstalk between dendritic and natural killer cells within the tumor microenvironment
- Author
-
Jacobs, Benedikt, Gebel, Veronika, Heger, Lukas, Grèze, Victoria, Schild, Hansjörg, Dudziak, Diana, and Ullrich, Evelyn
- Subjects
ddc:610 - Abstract
Cellular therapy has entered the daily clinical life with the approval of CAR T cell therapeutics and dendritic cell (DCs) vaccines in the US and the EU. In addition, numerous other adoptive cellular products, including natural killer (NK) cells, are currently evaluated in early phase I/ II clinical trials for the treatment of cancer patients. Despite these promising accomplishments, various challenges remain to be mastered in order to ensure sustained therapeutic success. These include the identification of strategies by which tumor cells escape the immune system or establish an immunosuppressive tumor microenvironment (TME). As part of the innate immune system, DCs and NK cells are both present within the TME of various tumor entities. While NK cells are well known for their intrinsic anti-tumor activity by their cytotoxicity capacities and the secretion of pro-inflammatory cytokines, the role of DCs within the TME is a double-edged sword as different DC subsets have been described with either tumor-promoting or -inhibiting characteristics. In this review, we will discuss recent findings on the interaction of DCs and NK cells under physiological conditions and within the TME. One focus is the crosstalk of various DC subsets with NK cells and their impact on the progression or inhibition of tumor growth. In addition, we will provide suggestions to overcome the immunosuppressive outcome of the interaction of DCs and NK cells within the TME.
- Published
- 2021
7. Unleashing the power of NK cells in anticancer immunotherapy
- Author
-
Vogler, Meike, primary, Shanmugalingam, Senthan, additional, Särchen, Vinzenz, additional, Reindl, Lisa Marie, additional, Grèze, Victoria, additional, Buchinger, Leon, additional, Kühn, Michael, additional, and Ullrich, Evelyn, additional
- Published
- 2021
- Full Text
- View/download PDF
8. Characterization and Manipulation of the Crosstalk Between Dendritic and Natural Killer Cells Within the Tumor Microenvironment
- Author
-
Jacobs, Benedikt, primary, Gebel, Veronika, additional, Heger, Lukas, additional, Grèze, Victoria, additional, Schild, Hansjörg, additional, Dudziak, Diana, additional, and Ullrich, Evelyn, additional
- Published
- 2021
- Full Text
- View/download PDF
9. Unleashing the power of NK cells in anticancer immunotherapy
- Author
-
Vogler, Meike, Shanmugalingam, Senthan, Särchen, Vinzenz, Reindl, Lisa Marie, Grèze, Victoria, Buchinger, Leon, Kühn, Michael, Ullrich, Evelyn, Vogler, Meike, Shanmugalingam, Senthan, Särchen, Vinzenz, Reindl, Lisa Marie, Grèze, Victoria, Buchinger, Leon, Kühn, Michael, and Ullrich, Evelyn
- Abstract
Due to their physiological role in removing damaged cells, natural killer (NK) cells represent ideal candidates for cellular immunotherapy in the treatment of cancer. Thereby, the cytotoxicity of NK cells is regulated by signals on both, the NK cells as well as the targeted tumor cells, and the interplay and balance of these signals determine the killing capacity of NK cells. One promising avenue in cancer treatment is therefore the combination of NK cell therapy with agents that either help to increase the killing capacity of NK cells or sensitize tumor cells to an NK cell-mediated attack. In this mini-review, we present different strategies that can be explored to unleash the potential of NK cell immunotherapy. In particular, we summarize how modulation of apoptosis signaling within tumor cells can be exploited to sensitize tumor cells to NK cell-mediated cytotoxicity.
- Published
- 2021
10. Sensitive and specific detection of Ewing sarcoma minimal residual disease in ovarian and testicular tissues
- Author
-
Laure, Chaput, Grèze, Victoria, Pascale, Halle, Nina, Robin, Bruno, Pereira, Lauren, Véronèse, Hervé, Lejeune, Philippe, Durand, Guillaume, Martin, Sanfilippo, Sandra, Michel, Canis, Justyna, Kanold, Andrei, Tchirkov, Brugnon, Florence, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand, Unité de Biostatistiques [CHU Clermont-Ferrand], Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), and CHU Clermont-Ferrand-CHU Clermont-Ferrand
- Subjects
[SDV]Life Sciences [q-bio] - Abstract
International audience; Sensitive and specific detection of Ewing sarcoma minimal residual disease in ovarian and testicular tissues Ewing sarcoma (EWS) is a common pediatric solid tumor with high metastatic potential. Due to toxic effects of treatments on reproductive functions, the cryopreservation of ovarian tissue (OT) or testicular tissue (TT) is recommended to preserve fertility. However, the risk to reintroduce residual metastatic tumor cells should be evaluated before fertility restoration. Our goal was to validate a sensitive and specific approach for EWS minimal residual disease (MRD) detection in frozen germinal tissues. Thawed OT (n=12) and TT (n=14) were contaminated with tumor RD-ES cells (10, 100 and 1000 cells) and EWS-FLI1 tumor-specific transcript was quantified with RT-qPCR. All contaminated samples were found to be positive, with the strong correlation between RD-ES cell numbers and EWS-FLI1 levels in OT (r=0.93) and TT (r=0.96) (P
- Published
- 2020
11. Cancers dans l'enfance et fertilité à l'âge adulte
- Author
-
Grèze, Victoria, CIC 1405, CIC/Centre de Pharmacologie Clinique, Université Clermont Auvergne [2017-2020], and Justyna Kanold
- Subjects
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,Gonadotoxicity ,Gonadotoxicité ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Maladie résiduelle ,Residual disease ,Childhood cancer ,Fertility preservation ,Cancer de l’enfant ,Préservation de la fertilité - Abstract
Advances in the treatment of childhood and adolescent cancers have led to real improvements as long-term survival is now over 80%. As a result, quality of life of these future adults is a major concern for the professionals involved in the care of these patients. Our work focuses on pubertal development and fertility, through epidemiological research and transfer research, in childhood cancer survivor.Concerning the "epidemiological research", female pubertal development and fertility were studied using the L.E.A cohort (Childhood and Adolescent Leukemias), which collects data about the outcome of patients treated for childhood leukemia. Although it is more important in women who received hematopoietic stem cell transplantation and/or relapsed, gonadotoxicity also affects those who received only first-line chemotherapy.In parallel, access to fertility preservation for adolescents and young adults treated for malignant diseases in Auvergne was analyzed. Boys benefit more from fertility consultation and preservation of their fertility. Progress should be made thanks the creation of clinico-biological platforms such as PREFERA (PREservation FERtilité Auvergne), which ensure better coordination between the different teams that support these patients.Concerning the "transfer research", we addressed the cryopreservation of gonadal tissues, only option for prepubertal children in particular, but with a potential risk of neoplastic cells reintroduction in case of future use. We developed sensitive and specific techniques of residual disease detection for two solid pediatric tumors whose current treatments are potentially sterilizing: neuroblastoma and Ewing's tumor. The interest is to have a diagnostic test usable for adults cured of these cancers, whose fertility has been compromised by the treatments and who have benefited from ovarian or testicular tissue cryopreservation.; Les progrès dans le traitement des cancers de l’enfant et de l’adolescent ont permis de réelles améliorations puisque la survie à long terme est maintenant de plus de 80%. De ce fait, la qualité de vie de ces futurs adultes est une préoccupation majeure des professionnels impliqués dans la prise en charge de ces patients. Notre travail se focalise en particulier sur le développement pubertaire et la fertilité, au travers de la recherche épidémiologique et de la recherche de transfert, chez les enfants et adolescents guéris d’un cancer.Sur le versant « recherche épidémiologique », le développement pubertaire et la fertilité chez la fille ont été étudiés à partir de la cohorte L.E.A. (Leucémies de l’Enfant et Adolescent), qui recueille des données concernant le devenir des patients traités pour une leucémie au cours de leur enfance. Bien qu’elle soit plus importante chez les femmes ayant bénéficié d’une greffe de cellules souches hématopoïétiques et/ou ayant rechuté, la gonadotoxicité atteint également celles n’ayant reçu que de la chimiothérapie en première ligne.En parallèle, l’accès à la préservation de la fertilité des adolescents et jeunes adultes pris en charge pour des pathologies malignes en Auvergne a été analysé. Les garçons bénéficient davantage de consultations au CECOS et d’une préservation de leur fertilité. Des progrès devraient se faire grâce à la création de plateformes clinico-biologiques telles que PREFERA (PREservation FERtilité Auvergne) qui assurent une meilleure coordination entre les différentes équipes prenant en charge ces patients. Sur le versant « recherche de transfert », nous nous sommes intéressés à la cryoconservation des tissus gonadiques, seule option envisageable chez les enfants prépubères notamment, mais comportant un risque potentiel de réintroduction de cellules néoplasiques en cas d’utilisation ultérieure. Nous avons mis au point des techniques sensibles et spécifiques de détection de la maladie résiduelle pour deux tumeurs solides pédiatriques dont les traitements actuels sont potentiellement stérilisants : le neuroblastome et la tumeur d’Ewing. L’intérêt étant de disposer d’un test diagnostic utilisable pour les adultes guéris de ces cancers, dont la fertilité a été compromise par les traitements et qui ont bénéficié d’une cryoconservation de tissu ovarien ou testiculaire.
- Published
- 2019
12. Childhood cancer and adulthood fertility
- Author
-
Grèze, Victoria, CIC 1405, CIC/Centre de Pharmacologie Clinique, Université Clermont Auvergne [2017-2020], and Justyna Kanold
- Subjects
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,Gonadotoxicity ,Gonadotoxicité ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Maladie résiduelle ,Residual disease ,Childhood cancer ,Fertility preservation ,Cancer de l’enfant ,Préservation de la fertilité - Abstract
Advances in the treatment of childhood and adolescent cancers have led to real improvements as long-term survival is now over 80%. As a result, quality of life of these future adults is a major concern for the professionals involved in the care of these patients. Our work focuses on pubertal development and fertility, through epidemiological research and transfer research, in childhood cancer survivor.Concerning the "epidemiological research", female pubertal development and fertility were studied using the L.E.A cohort (Childhood and Adolescent Leukemias), which collects data about the outcome of patients treated for childhood leukemia. Although it is more important in women who received hematopoietic stem cell transplantation and/or relapsed, gonadotoxicity also affects those who received only first-line chemotherapy.In parallel, access to fertility preservation for adolescents and young adults treated for malignant diseases in Auvergne was analyzed. Boys benefit more from fertility consultation and preservation of their fertility. Progress should be made thanks the creation of clinico-biological platforms such as PREFERA (PREservation FERtilité Auvergne), which ensure better coordination between the different teams that support these patients.Concerning the "transfer research", we addressed the cryopreservation of gonadal tissues, only option for prepubertal children in particular, but with a potential risk of neoplastic cells reintroduction in case of future use. We developed sensitive and specific techniques of residual disease detection for two solid pediatric tumors whose current treatments are potentially sterilizing: neuroblastoma and Ewing's tumor. The interest is to have a diagnostic test usable for adults cured of these cancers, whose fertility has been compromised by the treatments and who have benefited from ovarian or testicular tissue cryopreservation.; Les progrès dans le traitement des cancers de l’enfant et de l’adolescent ont permis de réelles améliorations puisque la survie à long terme est maintenant de plus de 80%. De ce fait, la qualité de vie de ces futurs adultes est une préoccupation majeure des professionnels impliqués dans la prise en charge de ces patients. Notre travail se focalise en particulier sur le développement pubertaire et la fertilité, au travers de la recherche épidémiologique et de la recherche de transfert, chez les enfants et adolescents guéris d’un cancer.Sur le versant « recherche épidémiologique », le développement pubertaire et la fertilité chez la fille ont été étudiés à partir de la cohorte L.E.A. (Leucémies de l’Enfant et Adolescent), qui recueille des données concernant le devenir des patients traités pour une leucémie au cours de leur enfance. Bien qu’elle soit plus importante chez les femmes ayant bénéficié d’une greffe de cellules souches hématopoïétiques et/ou ayant rechuté, la gonadotoxicité atteint également celles n’ayant reçu que de la chimiothérapie en première ligne.En parallèle, l’accès à la préservation de la fertilité des adolescents et jeunes adultes pris en charge pour des pathologies malignes en Auvergne a été analysé. Les garçons bénéficient davantage de consultations au CECOS et d’une préservation de leur fertilité. Des progrès devraient se faire grâce à la création de plateformes clinico-biologiques telles que PREFERA (PREservation FERtilité Auvergne) qui assurent une meilleure coordination entre les différentes équipes prenant en charge ces patients. Sur le versant « recherche de transfert », nous nous sommes intéressés à la cryoconservation des tissus gonadiques, seule option envisageable chez les enfants prépubères notamment, mais comportant un risque potentiel de réintroduction de cellules néoplasiques en cas d’utilisation ultérieure. Nous avons mis au point des techniques sensibles et spécifiques de détection de la maladie résiduelle pour deux tumeurs solides pédiatriques dont les traitements actuels sont potentiellement stérilisants : le neuroblastome et la tumeur d’Ewing. L’intérêt étant de disposer d’un test diagnostic utilisable pour les adultes guéris de ces cancers, dont la fertilité a été compromise par les traitements et qui ont bénéficié d’une cryoconservation de tissu ovarien ou testiculaire.
- Published
- 2019
13. Peripheral blood stem cell collection in children with extremely low body weight (≤8 kg). What have we learned over the past 25 years and where are the limits?
- Author
-
Grèze, Victoria, primary, Rouel, Nadège, additional, Rochette, Emmanuelle, additional, Merlin, Etienne, additional, Halle, Pascale, additional, Plantaz, Dominique, additional, Deméocq, François, additional, and Kanold, Justyna, additional
- Published
- 2020
- Full Text
- View/download PDF
14. Double L611S/V617F JAK2 mutation in a child with erythrocytosis
- Author
-
Lebecque, Benjamin, primary, Grèze, Victoria, additional, Tassin, Thomas, additional, Mareynat, Gabrielle, additional, Dannus, Louis‐Thomas, additional, Boiret‐Dupré, Nathalie, additional, Veyrat‐Masson, Richard, additional, Tribalat, Nathalie, additional, Berger, Marc Gabriel, additional, and Bourgne, Céline, additional
- Published
- 2020
- Full Text
- View/download PDF
15. Assessment of the architecture and integrity of frozen‐thawed testicular tissue from (pre)pubertal boys with cancer.
- Author
-
Rives‐Feraille, Aurélie, Liard, Agnès, Bubenheim, Michael, Barbotin, Anne Laure, Giscard d'Estaing, Sandrine, Mirallié, Sophie, Ancelle, Amélie, Roux, Christophe, Brugnon, Florence, Grèze, Victoria, Daudin, Myriam, Willson‐Plat, Geneviève, Dubois, Rémi, Sibert, Louis, Schneider, Pascale, and Rives, Nathalie
- Subjects
HEMATOPOIETIC stem cell transplantation ,DNA replication ,SEMINIFEROUS tubules ,SERTOLI cells ,FERTILITY preservation - Abstract
Background: Testicular tissue freezing is proposed for fertility preservation to (pre)pubertal boys with cancer before highly gonadotoxic treatment. Studies accurately comparing human (pre)pubertal testicular tissue quality before freezing and after thawing are exceptional. No study has reported this approach in a systematic manner and routine care. Objectives: To assess the impact of a control slow freezing protocol on testicular tissue architecture and integrity of (pre)pubertal boys after thawing. Materials and methods: (Pre)pubertal boys (n = 87) with cancer from 8 Reproductive Biology Laboratories of the French CECOS network benefited from testicular tissue freezing before hematopoietic stem cell transplantation. Seminiferous tubule cryodamage was determined histologically by scoring morphological alterations and by quantifying intratubular spermatogonia and the expression of DNA replication and repair marker in frozen‐thawed testicular fragments. Results: A significant increase in nuclear and epithelial score alterations was observed after thawing (p < 0.0001). The global lesional score remained lower than 1.5 and comparable to fresh testicular tissue. The number of intratubular spermatogonia and the expression of DNA replication and repair marker in spermatogonia and Sertoli cells did not vary significantly after thawing. These data showed the good preservation of the seminiferous tubule integrity and architecture after thawing, as previously reported in our studies performed in prepubertal mice and rats. Discussion: The current study reports, for the first time, the development of a semi‐quantitative analysis of cryodamage in human (pre)pubertal testicular tissue, using a rapid and useful tool that can be proposed in routine care to develop an internal and external quality control for testicular tissue freezing. This tool can also be used when changing one or several parameters of the freezing‐thawing procedure. Conclusion: Control slow freezing protocol without seeding maintains the seminiferous tubule architecture and integrity, the concentration of spermatogonia and the expression of DNA replication and repair marker in spermatogonia and Sertoli cells after thawing. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
16. Childhood Leukemia Survivors and Metabolic Response to Exercise: A Pilot Controlled Study
- Author
-
Pegon, Charline, primary, Rochette, Emmanuelle, additional, Rouel, Nadège, additional, Pereira, Bruno, additional, Doré, Eric, additional, Isfan, Florentina, additional, Grèze, Victoria, additional, Merlin, Etienne, additional, Kanold, Justyna, additional, and Duché, Pascale, additional
- Published
- 2020
- Full Text
- View/download PDF
17. Sensitive and Specific Detection of Ewing Sarcoma Minimal Residual Disease in Ovarian and Testicular Tissues in an In Vitro Model
- Author
-
Chaput, Laure, primary, Grèze, Victoria, additional, Halle, Pascale, additional, Radosevic-Robin, Nina, additional, Pereira, Bruno, additional, Véronèse, Lauren, additional, Lejeune, Hervé, additional, Durand, Philippe, additional, Martin, Guillaume, additional, Sanfilippo, Sandra, additional, Canis, Michel, additional, Kanold, Justyna, additional, Tchirkov, Andrei, additional, and Brugnon, Florence, additional
- Published
- 2019
- Full Text
- View/download PDF
18. Accès à la préservation de la fertilité des adolescents et jeunes adultes de 15 à 24 ans atteints de cancers en Auvergne, France
- Author
-
Grèze, Victoria, Mechdoud, Sabrina, Vorilhon, Solène, Isfan, Florentina, Rouel, Nadège, Chaput, Laure, Brugnon, Florence, Kanold, Justyna, CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand, Centre Hospitalier Universitaire de Clermont-Ferrand, Imagerie Moléculaire et Stratégies Théranostiques - Clermont Auvergne (IMoST), Université Clermont Auvergne (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Pédiatrie, Centre Hospitalier National Pédiatrique Charles de Gaulle (CHNP-CDG), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), Centre d'Investigation Clinique [CHU Clermont-Ferrand] (CIC 1405), Institut National de la Santé et de la Recherche Médicale (INSERM)-Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, and Imagerie Moléculaire et Stratégies Théranostiques (IMoST)
- Subjects
Cryopreservation ,Male ,Adolescent ,[SDV]Life Sciences [q-bio] ,Ovary ,Fertility Preservation ,[SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Spermatozoa ,Adolescents and young adults ,Préservation fertilité ,Young Adult ,Sex Factors ,Adolescents et jeunes adultes ,Oocytes ,Humans ,Female ,France ,Cancer ,Retrospective Studies - Abstract
Cancers of adolescents and young adults have particular epidemiological specificities. The improvement in their survival should be accompanied by an increased consideration of the treatments' side effects, among which the potential decrease in fertility. The objective of the study was to describe the access to fertility preservation of these patients at the University Hospital of Clermont-Ferrand over a period of 3 years.During this retrospective descriptive study, various socio-demographic and clinical data were collected.One hundred and fifty new cases of cancers were diagnosed in patients aged 15 to 24 years. Forty-four percent received at least one fertility consultation, 29 % for girls and 58 % for boys (P0.001). The number of cases that did not result in fertility preservation was significantly higher for girls than boys (P=0.005). Fertility preservation was mainly achieved by cryopreservation of ovarian tissue in female adolescents, ovocytes in young women and sperm in boys.We observed sex disparities in access to fertility preservation. Despite the existence of recommendations, progress remains to be made. The establishment of clinico-biological platforms should allow a better awareness of patients and professionals, and thus promote access to fertility preservation techniques for young patients with cancer.
- Published
- 2019
19. Peripheral blood stem cell collection in children with extremely low body weight (≤8 kg). What have we learned over the past 25 years and where are the limits?
- Author
-
Grèze, Victoria, Rouel, Nadège, Rochette, Emmanuelle, Merlin, Etienne, Halle, Pascale, Plantaz, Dominique, Deméocq, François, and Kanold, Justyna
- Subjects
LEUKAPHERESIS ,HEMATOPOIETIC stem cell transplantation ,BLOOD cells ,STEM cells ,BODY weight ,CHILD patients - Abstract
Hematopoietic progenitor cells‐apheresis (HPC‐A) collection is now a routine procedure for autologous hematopoietic stem cell transplantation. Here we present our 25 years' experience of HPC‐A collection in children weighing 8 kg or less, with a focus on the evolution of our standard operating procedures, and the safety limits for these young patients, in the Pediatric Apheresis Unit of Clermont‐Ferrand University Hospital (France). Fifteen children weighing 8 kg or less underwent 26 HPC‐A collections over 25 years. Median CD34+ cell yield by leukapheresis was 4.4 106/kg. No procedure‐related complications were encountered during or after the collection. No patient had profound thrombocytopenia or anemia that needed post‐collection transfusions. Our experience in pediatric oncology patients who underwent HPC‐A collections shows that this procedure can be performed even in the smallest of children with no increase in toxicity provided all precautions are taken to ensure that the procedure is carried out under the ideal conditions. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
20. In vitro assessment of edoxaban anticoagulant effect in pediatric plasma
- Author
-
Sinegre, Thomas, primary, Zlobecki, Mélissa, additional, Doré, Eric, additional, Pereira, Bruno, additional, Grèze, Victoria, additional, and Lebreton, Aurélien, additional
- Published
- 2019
- Full Text
- View/download PDF
21. [Fertility preservation in oncology]
- Author
-
Chaput, Laure, Gremeau, Anne-Sophie, Vorilhon, Solène, Pons-Rejraji, Hanae, Chabrot, Cécile, Grèze, Victoria, Pouly, Jean-Luc, Brugnon, Florence, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre d'Assistance Médicale à la Procréation [CHU Clermont-Ferrand] (AMP CECOS), CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, CHU Gabriel Montpied [Clermont-Ferrand], and CHU Clermont-Ferrand
- Subjects
Adult ,Cryopreservation ,Male ,[SDV]Life Sciences [q-bio] ,Ovary ,Age Factors ,Fertility Preservation ,Embryo, Mammalian ,Spermatozoa ,Préservation fertilité ,Sex Factors ,Neoplasms ,Testis ,Oocytes ,Humans ,Female ,Traitements gonadotoxiques ,Survivors ,Cryoconservation tissus germinaux ,Cryoconservation gamètes ,Cancer - Abstract
International audience; Since the improvement of cancer diagnosis and treatment, survival rates of these patients increase. Gonadal damages are frequent consequences of cancer treatments with different evidence of impaired fertility. In this context, fertility preservation should be proposed to patients exposed to potentially gonadotoxic treatments. Different preservation approaches may be proposed depending on patient age, sex, cancer type and type of treatment. The indications of fertility preservation depend on sexual maturity. In young girls, ovarian cortex cryopreservation is the only technique feasible in order to preserve their reproductive potential. Vitrification of oocytes which needs ovarian stimulation or oocytes in vitro maturation is becoming more commonly performed for pubertal women to preserve their fertility. Ovarian cortex freezing could be offered to emergency fertility preservation of adult female cancer patients. In prepubertal boys, testicular tissue cryopreservation is the only line treatment for fertility preservation. For future use, various approaches are being evaluated such as spermatogonial stem cell injection or in vitro maturation. Cryopreservation of spermatozoa is, today, an established and successful technique for male adults. When there are no spermatozoa in ejaculate, sperm can be retrieved after treatment of testicular biopsy. The French bioethics law clearly indicates that fertility preservation should be proposed to patients exposed to potentially gonadotoxic treatment. Today, many approaches are possible. Fertility preservation indications are based on multidisciplinary consultations within platforms for the fertility preservation in order to optimize the patient care.; Avec les progrès diagnostiques et thérapeutiques, la survie des patients atteints de cancer s'est améliorée ces dernières années. La toxicité gonadique reste une conséquence relativement fréquente des traitements utilisés avec différents niveaux d'altération de la fertilité. Dans cecontexte, la préservation de la fertilité doit être proposée aux patient(e) exposé(e)s à un traitement potentiellement gonadotoxique. Différentes options sont proposées selon l'âge du patient, son sexe, l'urgence thérapeutique et l'évaluation des retentissements potentiels sur lafertilité. Chez les femmes prépubères, la congélation de tissu ovarien est la seule option possible. Après la puberté, la vitrification ovocytaire est de plus en plus utilisée mais nécessite une stimulation hormonale ou une maturation in vitro des ovocytes. Lorsque l'urgence thérapeutiquene permet pas le délai d'une stimulation, la congélation de cortex ovarien est l'option privilégiée. Chez les garçons prépubères, la congélation de tissu testiculaire est proposée. Pour l'utilisation ultérieure du tissu cryoconservé, différentes techniques sont en cours d'évaluation telles quel'injection de cellules souches ou la maturation in vitro. Concernant l'homme adulte, la congélation de spermatozoïdes est pratiquée depuis des années et son efficacité en Assistance médicale à la procréation est aujourd'hui clairement démontrée. La loi de bioéthique précise clairement que la préservation de la fertilité doit être proposée aux patients exposés à un traitement potentiellement gonadotoxique. De nombreuses méthodes sont aujourd'hui possibles. Les indications de préservation dans le cadre du cancer relèvent d'une concertation multidisciplinaire au sein des plateformes clinicobiologiques de préservation de la fertilité afin d'optimiser la prise en charge despatients.
- Published
- 2017
22. Préservation de la fertilité en cancérologie
- Author
-
Chaput, Laure, primary, Grémeau, Anne-Sophie, additional, Vorilhon, Solène, additional, Pons, Hanae, additional, Chabrot, Cécile, additional, Grèze, Victoria, additional, Pouly, Jean-Luc, additional, and Brugnon, Florence, additional
- Published
- 2018
- Full Text
- View/download PDF
23. Highly sensitive assessment of neuroblastoma minimal residual disease in ovarian tissue using RT-qPCR-A strategy for improving the safety of fertility restoration.
- Author
-
Grèze, Victoria, Brugnon, Florence, Chambon, Fanny, Halle, Pascale, Canis, Michel, Amiot, Clotilde, Grémeau, Anne‐Sophie, Pereira, Bruno, Yáñez Peralta, Yania, Tchirkov, Andrei, Kanold, Justyna, Grèze, Victoria, Grémeau, Anne-Sophie, and Yáñez Peralta, Yania
- Published
- 2017
- Full Text
- View/download PDF
24. RT-qPCR for PHOX2B mRNA is a highly specific and sensitive method to assess neuroblastoma minimal residual disease in testicular tissue
- Author
-
Grèze, Victoria, primary, Kanold, Justyna, additional, Chambon, Fanny, additional, Halle, Pascale, additional, Gremeau, Anne-Sophie, additional, Rives, Nathalie, additional, Rouel, Nadège, additional, Pereira, Bruno, additional, Tchirkov, Andrei, additional, and Brugnon, Florence, additional
- Published
- 2017
- Full Text
- View/download PDF
25. Double L611S/V617F JAK2 mutation in a child with erythrocytosis.
- Author
-
Lebecque, Benjamin, Grèze, Victoria, Tassin, Thomas, Mareynat, Gabrielle, Dannus, Louis‐Thomas, Boiret‐Dupré, Nathalie, Veyrat‐Masson, Richard, Tribalat, Nathalie, Berger, Marc Gabriel, and Bourgne, Céline
- Published
- 2021
- Full Text
- View/download PDF
26. Highly sensitive assessment of neuroblastoma minimal residual disease in ovarian tissue using RT-qPCR-A strategy for improving the safety of fertility restoration
- Author
-
Grèze, Victoria, primary, Brugnon, Florence, additional, Chambon, Fanny, additional, Halle, Pascale, additional, Canis, Michel, additional, Amiot, Clotilde, additional, Grémeau, Anne-Sophie, additional, Pereira, Bruno, additional, Yáñez Peralta, Yania, additional, Tchirkov, Andrei, additional, and Kanold, Justyna, additional
- Published
- 2016
- Full Text
- View/download PDF
27. Cryopreservation of ovarian tissue in pediatric patients undergoing sterilizing chemotherapy
- Author
-
Chambon, Fanny, primary, Brugnon, Florence, additional, Grèze, Victoria, additional, Grémeau, Anne-Sophie, additional, Pereira, Bruno, additional, Déchelotte, Pierre, additional, and Kanold, Justyna, additional
- Published
- 2016
- Full Text
- View/download PDF
28. Leukapheresis in Management of Hyperleukocytosis in Children’s Leukemias
- Author
-
Grèze, Victoria, primary, Chambon, Fanny, additional, Merlin, Etienne, additional, Rochette, Emmanuelle, additional, Isfan, Florentina, additional, Deméocq, François, additional, and Kanold, Justyna, additional
- Published
- 2014
- Full Text
- View/download PDF
29. [Fertility preservation in oncology].
- Author
-
Chaput L, Grémeau AS, Vorilhon S, Pons H, Chabrot C, Grèze V, Pouly JL, and Brugnon F
- Subjects
- Adult, Age Factors, Embryo, Mammalian, Female, Humans, Male, Sex Factors, Survivors, Cryopreservation methods, Fertility Preservation methods, Neoplasms therapy, Oocytes, Ovary, Spermatozoa, Testis
- Abstract
Since the improvement of cancer diagnosis and treatment, survival rates of these patients increase. Gonadal damages are frequent consequences of cancer treatments with different evidence of impaired fertility. In this context, fertility preservation should be proposed to patients exposed to potentially gonadotoxic treatments. Different preservation approaches may be proposed depending on patient age, sex, cancer type and type of treatment. The indications of fertility preservation depend on sexual maturity. In young girls, ovarian cortex cryopreservation is the only technique feasible in order to preserve their reproductive potential. Vitrification of oocytes which needs ovarian stimulation or oocytes in vitro maturation is becoming more commonly performed for pubertal women to preserve their fertility. Ovarian cortex freezing could be offered to emergency fertility preservation of adult female cancer patients. In prepubertal boys, testicular tissue cryopreservation is the only line treatment for fertility preservation. For future use, various approaches are being evaluated such as spermatogonial stem cell injection or in vitro maturation. Cryopreservation of spermatozoa is, today, an established and successful technique for male adults. When there are no spermatozoa in ejaculate, sperm can be retrieved after treatment of testicular biopsy. The French bioethics law clearly indicates that fertility preservation should be proposed to patients exposed to potentially gonadotoxic treatment. Today, many approaches are possible. Fertility preservation indications are based on multidisciplinary consultations within platforms for the fertility preservation in order to optimize the patient care., (Copyright © 2017 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.