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4 results on '"Goyal, Vimal Kant"'

3. Efficacy and safety of fixed dose com bination of art erolane maleate and piperaquine phosphate in comparison with chloroquine phosphate in children with acute uncomplicated Plasmodium vivax malaria: A phase III, randomised, multicentric study.

Author

Valecha, Neena, Goyal, Vimal Kant, Mishra, Deo Nidhi, Das, Rashmi Ranjan, Jauhri, Neeraj, Bhardwaj, Alok Chandra, Khurana, Omesh, Choudhury, Reena, Pandey, Madhukar, Baliga, Bantwal Shantharam, Ghosh, Susanta Kumar, Srivastava, Bina, Soans, Santhosh T., Bahl, Raj Kamal, Punj, Ajay, Roy, Arjun, Sharma, Sanjay K., Nasa, Amit, Jalali, Rajinder K., and Anvikar, Anupkumar R.

Published
2020

4. Efficacy and safety of fixed dose combination of arterolane maleate and piperaquine phosphate in comparison with chloroquine phosphate in children with acute uncomplicated Plasmodium vivax malaria: A phase III, randomised, multicentric study.

Author

Valecha N, Goyal VK, Mishra DN, Das RR, Jauhri N, Bhardwaj AC, Khurana O, Choudhury R, Pandey M, Baliga BS, Ghosh SK, Srivastava B, Soans ST, Bahl RK, Punj A, Roy A, Sharma SK, Nasa A, Jalali RK, and Anvikar AR

Subjects
Child, Chloroquine adverse effects, Chloroquine analogs & derivatives, Heterocyclic Compounds, 1-Ring, Humans, Maleates therapeutic use, Peroxides, Phosphates therapeutic use, Plasmodium vivax, Quinolines, Spiro Compounds, Antimalarials adverse effects, Malaria, Falciparum drug therapy, Malaria, Vivax drug therapy
Abstract

Background & Objectives: In India, the burden of Plasmodium vivax malaria has been projected to be highest in some areas. This study investigated the efficacy and safety of fixed dose combination (FDC) of arterolane maleate (AM) 37.5 mg and piperaquine phosphate 187.5 mg (PQP) dispersible tablets and (not with) chloroquine in the treatment of uncomplicated vivax malaria in pediatric patients., Methods: This multicentric, open-label trial was carried out at 12 sites in India. A total of 164 patients aged 6 months to 12 years with P. vivax malaria were randomized in a ratio of 2:1 to AM-PQP (111 patients) or chloroquine (53 patients) arms. The duration of follow up was 42 days., Results: At 72 hours, the proportion of a parasitaemic and afebrile patients was 100% in both treatment arms in per protocol (PP) population, and 98.2% and 100% [95% CI: -1.8 (-6.33 to 5.08)] in AM-PQP and chloroquine arms, respectively, in intent to treat (ITT) population. The efficacy and safety of AM-PQP was found to be comparable to chloroquine in the treatment of uncomplicated P. vivax malaria in pediatric patients. Overall, the cure rate at Day 28 and 42 was >95% for both AM-PQP or CQ. The commonly reported clinical adverse event was vomiting. No patient was discontinued for any QTc abnormality., Interpretation & Conclusion: The efficacy and safety of FDC of arterolane maleate and piperaquine phosphate was found to be comparable to chloroquine for treatment of uncomplicated P. vivax malaria in pediatric patients., Competing Interests: None

Published
2020
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