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4. Supplementary Figure 1 from Early [18F]Fluorodeoxyglucose Positron Emission Tomography at Two Days of Gefitinib Treatment Predicts Clinical Outcome in Patients with Adenocarcinoma of the Lung

Author

Takahashi, Ryo, primary, Hirata, Haruhiko, primary, Tachibana, Isao, primary, Shimosegawa, Eku, primary, Inoue, Atsuo, primary, Nagatomo, Izumi, primary, Takeda, Yoshito, primary, Kida, Hiroshi, primary, Goya, Sho, primary, Kijima, Takashi, primary, Yoshida, Mitsuhiro, primary, Kumagai, Toru, primary, Kumanogoh, Atsushi, primary, Okumura, Meinoshin, primary, Hatazawa, Jun, primary, and Kawase, Ichiro, primary

Published
2023
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5. Supplementary Figure Legends 1 from Early [18F]Fluorodeoxyglucose Positron Emission Tomography at Two Days of Gefitinib Treatment Predicts Clinical Outcome in Patients with Adenocarcinoma of the Lung

Author

Takahashi, Ryo, primary, Hirata, Haruhiko, primary, Tachibana, Isao, primary, Shimosegawa, Eku, primary, Inoue, Atsuo, primary, Nagatomo, Izumi, primary, Takeda, Yoshito, primary, Kida, Hiroshi, primary, Goya, Sho, primary, Kijima, Takashi, primary, Yoshida, Mitsuhiro, primary, Kumagai, Toru, primary, Kumanogoh, Atsushi, primary, Okumura, Meinoshin, primary, Hatazawa, Jun, primary, and Kawase, Ichiro, primary

Published
2023
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6. Data from Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis

Author

Ihara, Shoichi, primary, Kida, Hiroshi, primary, Arase, Hisashi, primary, Tripathi, Lokesh P., primary, Chen, Yi-An, primary, Kimura, Tetsuya, primary, Yoshida, Mitsuhiro, primary, Kashiwa, Yozo, primary, Hirata, Haruhiko, primary, Fukamizu, Reiko, primary, Inoue, Ruriko, primary, Hasegawa, Kana, primary, Goya, Sho, primary, Takahashi, Ryo, primary, Minami, Toshiyuki, primary, Tsujino, Kazuyuki, primary, Suzuki, Mayumi, primary, Kohmo, Satoshi, primary, Inoue, Koji, primary, Nagatomo, Izumi, primary, Takeda, Yoshito, primary, Kijima, Takashi, primary, Mizuguchi, Kenji, primary, Tachibana, Isao, primary, and Kumanogoh, Atsushi, primary

Published
2023
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7. Supplementary Figure 1 from Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis

Author

Ihara, Shoichi, primary, Kida, Hiroshi, primary, Arase, Hisashi, primary, Tripathi, Lokesh P., primary, Chen, Yi-An, primary, Kimura, Tetsuya, primary, Yoshida, Mitsuhiro, primary, Kashiwa, Yozo, primary, Hirata, Haruhiko, primary, Fukamizu, Reiko, primary, Inoue, Ruriko, primary, Hasegawa, Kana, primary, Goya, Sho, primary, Takahashi, Ryo, primary, Minami, Toshiyuki, primary, Tsujino, Kazuyuki, primary, Suzuki, Mayumi, primary, Kohmo, Satoshi, primary, Inoue, Koji, primary, Nagatomo, Izumi, primary, Takeda, Yoshito, primary, Kijima, Takashi, primary, Mizuguchi, Kenji, primary, Tachibana, Isao, primary, and Kumanogoh, Atsushi, primary

Published
2023
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8. Supplementary Table 4 from Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis

Author

Ihara, Shoichi, primary, Kida, Hiroshi, primary, Arase, Hisashi, primary, Tripathi, Lokesh P., primary, Chen, Yi-An, primary, Kimura, Tetsuya, primary, Yoshida, Mitsuhiro, primary, Kashiwa, Yozo, primary, Hirata, Haruhiko, primary, Fukamizu, Reiko, primary, Inoue, Ruriko, primary, Hasegawa, Kana, primary, Goya, Sho, primary, Takahashi, Ryo, primary, Minami, Toshiyuki, primary, Tsujino, Kazuyuki, primary, Suzuki, Mayumi, primary, Kohmo, Satoshi, primary, Inoue, Koji, primary, Nagatomo, Izumi, primary, Takeda, Yoshito, primary, Kijima, Takashi, primary, Mizuguchi, Kenji, primary, Tachibana, Isao, primary, and Kumanogoh, Atsushi, primary

Published
2023
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9. Supplementary Table 2 from Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis

Author

Ihara, Shoichi, primary, Kida, Hiroshi, primary, Arase, Hisashi, primary, Tripathi, Lokesh P., primary, Chen, Yi-An, primary, Kimura, Tetsuya, primary, Yoshida, Mitsuhiro, primary, Kashiwa, Yozo, primary, Hirata, Haruhiko, primary, Fukamizu, Reiko, primary, Inoue, Ruriko, primary, Hasegawa, Kana, primary, Goya, Sho, primary, Takahashi, Ryo, primary, Minami, Toshiyuki, primary, Tsujino, Kazuyuki, primary, Suzuki, Mayumi, primary, Kohmo, Satoshi, primary, Inoue, Koji, primary, Nagatomo, Izumi, primary, Takeda, Yoshito, primary, Kijima, Takashi, primary, Mizuguchi, Kenji, primary, Tachibana, Isao, primary, and Kumanogoh, Atsushi, primary

Published
2023
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10. Supplementary Methods, Figures 1-2 from Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis

Author

Ihara, Shoichi, primary, Kida, Hiroshi, primary, Arase, Hisashi, primary, Tripathi, Lokesh P., primary, Chen, Yi-An, primary, Kimura, Tetsuya, primary, Yoshida, Mitsuhiro, primary, Kashiwa, Yozo, primary, Hirata, Haruhiko, primary, Fukamizu, Reiko, primary, Inoue, Ruriko, primary, Hasegawa, Kana, primary, Goya, Sho, primary, Takahashi, Ryo, primary, Minami, Toshiyuki, primary, Tsujino, Kazuyuki, primary, Suzuki, Mayumi, primary, Kohmo, Satoshi, primary, Inoue, Koji, primary, Nagatomo, Izumi, primary, Takeda, Yoshito, primary, Kijima, Takashi, primary, Mizuguchi, Kenji, primary, Tachibana, Isao, primary, and Kumanogoh, Atsushi, primary

Published
2023
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11. Supplementary Table 1 from Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis

Author

Ihara, Shoichi, primary, Kida, Hiroshi, primary, Arase, Hisashi, primary, Tripathi, Lokesh P., primary, Chen, Yi-An, primary, Kimura, Tetsuya, primary, Yoshida, Mitsuhiro, primary, Kashiwa, Yozo, primary, Hirata, Haruhiko, primary, Fukamizu, Reiko, primary, Inoue, Ruriko, primary, Hasegawa, Kana, primary, Goya, Sho, primary, Takahashi, Ryo, primary, Minami, Toshiyuki, primary, Tsujino, Kazuyuki, primary, Suzuki, Mayumi, primary, Kohmo, Satoshi, primary, Inoue, Koji, primary, Nagatomo, Izumi, primary, Takeda, Yoshito, primary, Kijima, Takashi, primary, Mizuguchi, Kenji, primary, Tachibana, Isao, primary, and Kumanogoh, Atsushi, primary

Published
2023
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12. Supplementary Table 3 from Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis

Author

Ihara, Shoichi, primary, Kida, Hiroshi, primary, Arase, Hisashi, primary, Tripathi, Lokesh P., primary, Chen, Yi-An, primary, Kimura, Tetsuya, primary, Yoshida, Mitsuhiro, primary, Kashiwa, Yozo, primary, Hirata, Haruhiko, primary, Fukamizu, Reiko, primary, Inoue, Ruriko, primary, Hasegawa, Kana, primary, Goya, Sho, primary, Takahashi, Ryo, primary, Minami, Toshiyuki, primary, Tsujino, Kazuyuki, primary, Suzuki, Mayumi, primary, Kohmo, Satoshi, primary, Inoue, Koji, primary, Nagatomo, Izumi, primary, Takeda, Yoshito, primary, Kijima, Takashi, primary, Mizuguchi, Kenji, primary, Tachibana, Isao, primary, and Kumanogoh, Atsushi, primary

Published
2023
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13. Supplementary Figure 2 from Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis

Author

Ihara, Shoichi, primary, Kida, Hiroshi, primary, Arase, Hisashi, primary, Tripathi, Lokesh P., primary, Chen, Yi-An, primary, Kimura, Tetsuya, primary, Yoshida, Mitsuhiro, primary, Kashiwa, Yozo, primary, Hirata, Haruhiko, primary, Fukamizu, Reiko, primary, Inoue, Ruriko, primary, Hasegawa, Kana, primary, Goya, Sho, primary, Takahashi, Ryo, primary, Minami, Toshiyuki, primary, Tsujino, Kazuyuki, primary, Suzuki, Mayumi, primary, Kohmo, Satoshi, primary, Inoue, Koji, primary, Nagatomo, Izumi, primary, Takeda, Yoshito, primary, Kijima, Takashi, primary, Mizuguchi, Kenji, primary, Tachibana, Isao, primary, and Kumanogoh, Atsushi, primary

Published
2023
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14. Systematic review and meta-analysis of the efficacy of benzodiazepines for dyspnea in patients with cancer

Author

Yasuda, Shuntaro, primary, Sugano, Koji, additional, Matsuda, Yoshinobu, additional, Kako, Jun, additional, Takagi, Yusuke, additional, Watanabe, Hiroaki, additional, Kasahara, Yoko, additional, Goya, Sho, additional, Kohara, Hiroyuki, additional, Mori, Masanori, additional, Nakayama, Takeo, additional, and Yamaguchi, Takashi, additional

Published
2023
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15. The Effect of High-flow Nasal Cannula Oxygen for Dyspnea in Patients with Advanced Disease: Systematic Review

Author

Goya, Sho, primary, Nakano, Yasushi, additional, Tsukuura, Hiroaki, additional, Takagi, Yusuke, additional, Watanabe, Hiroaki, additional, Matsuda, Yoshinobu, additional, Kako, Jun, additional, Kasahara, Yoko, additional, Kohara, Hiroyuki, additional, Mori, Masanori, additional, Nakayama, Takeo, additional, and Yamaguchi, Takashi, additional

Published
2023
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24. Hemophagocytic Lymphohistiocytosis That Developed Soon After the Initial Administration of Atezolizumab, Which Is an Anti-PD-L1 Antibody Drug, and Thereafter Deteriorated Rapidly: an Autopsy Case

Author

Yamaguchi, Norihiko, primary, Miyamoto, Aiko, additional, Kuniya, Kento, additional, Azuma, Koji, additional, Osa, Akio, additional, Goya, Sho, additional, Kusu, Takashi, additional, Nishioka, Kiyonori, additional, Hirayama, Kyo, additional, and Sakai, Shunsuke, additional

Published
2020
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27. A p38 MAPK inhibitor, FR-167653, ameliorates murine bleomycin-induced pulmonary fibrosis

Author

Matsuoka, Hiroto, Arai, Toru, Mori, Masahide, Goya, Sho, Kida, Hiroshi, Morishita, Hiroshi, Fujiwara, Hiroshi, Tachibana, Isao, Osaki, Tadashi, and Hayashi, Seiji

Subjects
Bleomycin -- Evaluation, Pulmonary fibrosis -- Evaluation, Mice as laboratory animals -- Usage, Protein kinases -- Research, Lungs -- Physiological aspects, Tumor necrosis factor -- Research, Growth factors -- Research, Biological sciences
Abstract

A p38 MAPK inhibitor, FR-167653, ameliorates murine bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 283: L103-L112, 2002. First published February 15, 2002; 10.1152/ajplung.00187.2001.--To elucidate the pathophysiology of pulmonary fibrosis, we investigated the involvement of p38 mitogen-activated protein kinase (MAPK), which is one of the major signal transduction pathways of proinflammatory cytokines, in a murine model of bleomycin-induced lung fibrosis, p38 MAPK and its substrate, activating transcription factor (ATF)-2, in bronchoalveolar lavage fluid cells were phosphorylated by intratracheal exposure of bleomycin, and the phosphorylation of ATF-2 was inhibited by subcutaneous administration of a specific inhibitor of p38 MAPK, FR-167653. FR-167653 also inhibited augmented expression of tumor necrosis factor -[alpha], connective tissue growth factor, and apoptosis of lung cells induced by bleomycin administration. Moreover, daily subcutaneous administration of FR-167653 (from 1 day before to 14 days after bleomycin administration) ameliorated pulmonary fibrosis and pulmonary cachexia induced by bleomycin. These findings demonstrated that p38 MAPK is involved in bleomycin-induced pulmonary fibrosis, and its inhibitor, FR-167653, may be a feasible therapeutic agent. phosphorylation of p38 mitogen-activated protein kinase; tumor necrosis factor-[alpha]; connective tissue growth factor; anti-apoptotic effect

Published
2002

36. Introduction of the interleukin-10 gene into mice inhibited bleomycin-induced lung injury in vivo

Author

ARAI, TORU, ABE, KIN'YA, MATSUOKA, HIROTO, YOSHIDA, MITSUHIRO MORI, MASAHIDE, GOYA, SHO, KIDA, HIROSHI, NISHINO, KAZUMI OSAKI, TADASHI, TACHIBANA, ISAO, KANEDA, YASUFUMI, and HAYASHI, SEIJI

Subjects
Interleukin-10 -- Research, Pulmonary fibrosis -- Research, Collagen -- Research, Biological sciences
Abstract

Introduction of the interleukin-10 gene into mice inhibited bleomycin-induced lung injury in vivo. Am J Physiol Lung Cell Mol Physiol 278: L914-L922, 2000.--Interleukin (IL)-10 has been shown to reduce many inflammatory reactions. We investigated the in vivo effects of IL-10 on a bleomycin-induced lung injury model. Hemagglutinating virus of Japan (HVJ)-liposomes containing a human IL-10 expression vector (hIL10-HVJ) or a balanced salt solution as a control (Cont-HVJ) was intraperitoneally injected into mice on day -3. This was followed by intratracheal instillation of bleomycin (0.8 mg/kg) on day 0. Myeloperoxidase activity of bronchoalveolar lavage fluid and tumor necrosis factor-[Alpha] mRNA expression in bronchoalveolar lavage fluid cells on day 7 and hydroxyproline content of the whole lung on day 21 were inhibited significantly by hILl0-HVJ treatment. However, Cont-HVJ treatment could not suppress any of these parameters. We also examined the in vitro effects of IL-10 on the human lung fibroblast cell line WI-38. IL-10 significantly reduced constitutive and transforming growth factor-[Beta]-stimulated type I collagen mRNA expression. However, IL-10 did not affect the proliferation of WI-38 cells induced by platelet-derived growth factor. These data suggested that exogenous IL-10 may be useful in the treatment of pulmonary fibrosis. transforming growth factor-[Beta]; pulmonary fibrosis; collagen

Published
2000

38. Clinical Course of Lung Cancer Patients with Subcutaneously Implanted Central Venous Access Device Ports from the Time of Receiving Chemotherapy to the Endpoint of Cancer

Author

Hirashima, Tomonori, primary, Tsumori, Teppei, additional, Sakai, Kenichi, additional, Fujishima, Makoto, additional, Yamakawa, Yukie, additional, Ryouta, Noriko, additional, Sandoh, Masumi, additional, Shiroyama, Takayuki, additional, Tamiya, Motohiro, additional, Morishita, Naoko, additional, Suzuki, Hidekazu, additional, Okamoto, Norio, additional, Goya, Sho, additional, and Shigeoka, Hironori, additional

Published
2016
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39. Novel Therapeutic Strategies for Delirium in Patients With Cancer

Author

Tanimukai, Hitoshi, primary, Tsujimoto, Hiroshi, additional, Matsuda, Yoshinobu, additional, Tokoro, Akihiro, additional, Kanemura, Seitetsu, additional, Watanabe, Motoo, additional, Tsujio, Ichiro, additional, Maeda, Isseki, additional, Takei, Kiyozumi, additional, Nakajima, Shinichiro, additional, Taira, Toshihiro, additional, Tokuyama, Madoka, additional, Kai, Toshihiro, additional, Okamoto, Yoshiaki, additional, Goya, Sho, additional, and Kashiwagi, Yujiro, additional

Published
2014
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40. 4-Hydroxy-2-nonenal induces endothelial cell injury via PKCdelta and biphasic JNK activation

Author

Goya, Sho, Hirata, Haruhiko, Hoshino, Shigenori, Inoue, Koji, Kashiwa, Yozo, Kawase, Ichiro, Kijima, Takashi, Kumagai, Toru, Mayumi, Masahiko, Osaki, Tadashi, Suzuki, Mayumi, Tachibana, Isao, Takeda, Yoshito, Takimoto, Takayuki, Yano, Yukihiro, and Yoshida, Yoshida

Subjects
kinase, endothelial cell, 4-Hydroxy-2-nonenal, oxidative stress, protein, c-Jun N-terminal kinase, Cd, cell injury
Abstract

4-Hydroxy-2-nonenal (4-HNE), a major product generated during oxidative stress, exhibits cytotoxic effects; however, the mechanisms of 4-HNE-induced endothelial cell injury are not well defined. To explore this issue, we examined how 4-HNE damages human umbilical vein endothelial cells (HUVECs) and found that 4-HNE induced biphasic activation of c-Jun N-terminal kinase (JNK). Both pre- and post-treatment of HUVECs with SP600125, a specific JNK inhibitor, significantly suppressed the cytotoxic effects of 4-HNE. Inhibition of protein kinase Cd (PKCd), which was also phosphorylated by 4-HNE, reduced endothelial cell injury as well as late-phase JNK phosphorylation elicited by 4-HNE. Inversely, pre-treatment of HUVECs with SP600125 suppressed PKCd activation. Taken together, these results support the concept that 4-HNE induces vascular endothelial cell injury by the interaction between biphasic JNK activation and the PKCd pathway., EXCLI Journal ; Vol. 7, 2008

Published
2008

41. Deletion of Tetraspanin CD9 Diminishes Lymphangiogenesis in Vivo and in Vitro

Author

Iwasaki, Takeo, primary, Takeda, Yoshito, additional, Maruyama, Kazuichi, additional, Yokosaki, Yasuyuki, additional, Tsujino, Kazuyuki, additional, Tetsumoto, Satoshi, additional, Kuhara, Hanako, additional, Nakanishi, Kaori, additional, Otani, Yasushi, additional, Jin, Yingji, additional, Kohmo, Satoshi, additional, Hirata, Haruhiko, additional, Takahashi, Ryo, additional, Suzuki, Mayumi, additional, Inoue, Koji, additional, Nagatomo, Izumi, additional, Goya, Sho, additional, Kijima, Takashi, additional, Kumagai, Toru, additional, Tachibana, Isao, additional, Kawase, Ichiro, additional, and Kumanogoh, Atsushi, additional

Published
2013
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42. An Inhibitory Role for Sema4A in Antigen-Specific Allergic Asthma

Author

Morihana, Tetsuo, primary, Goya, Sho, additional, Mizui, Masayuki, additional, Yasui, Teruhito, additional, Prasad, Durubaka V. R., additional, Kumanogoh, Atsushi, additional, Tamura, Manabu, additional, Shikina, Takashi, additional, Maeda, Yohei, additional, Iwamoto, Yoriko, additional, Inohara, Hidenori, additional, and Kikutani, Hitoshi, additional

Published
2012
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43. Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis

Author

Ihara, Shoichi, primary, Kida, Hiroshi, additional, Arase, Hisashi, additional, Tripathi, Lokesh P., additional, Chen, Yi-An, additional, Kimura, Tetsuya, additional, Yoshida, Mitsuhiro, additional, Kashiwa, Yozo, additional, Hirata, Haruhiko, additional, Fukamizu, Reiko, additional, Inoue, Ruriko, additional, Hasegawa, Kana, additional, Goya, Sho, additional, Takahashi, Ryo, additional, Minami, Toshiyuki, additional, Tsujino, Kazuyuki, additional, Suzuki, Mayumi, additional, Kohmo, Satoshi, additional, Inoue, Koji, additional, Nagatomo, Izumi, additional, Takeda, Yoshito, additional, Kijima, Takashi, additional, Mizuguchi, Kenji, additional, Tachibana, Isao, additional, and Kumanogoh, Atsushi, additional

Published
2012
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45. Early [18F]Fluorodeoxyglucose Positron Emission Tomography at Two Days of Gefitinib Treatment Predicts Clinical Outcome in Patients with Adenocarcinoma of the Lung

Author

Takahashi, Ryo, primary, Hirata, Haruhiko, additional, Tachibana, Isao, additional, Shimosegawa, Eku, additional, Inoue, Atsuo, additional, Nagatomo, Izumi, additional, Takeda, Yoshito, additional, Kida, Hiroshi, additional, Goya, Sho, additional, Kijima, Takashi, additional, Yoshida, Mitsuhiro, additional, Kumagai, Toru, additional, Kumanogoh, Atsushi, additional, Okumura, Meinoshin, additional, Hatazawa, Jun, additional, and Kawase, Ichiro, additional

Published
2012
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46. Safe and Successful Treatment With Erlotinib After Gefitinib-Induced Hepatotoxicity: Difference in Metabolism As a Possible Mechanism

Author

Kijima, Takashi, primary, Shimizu, Tomohito, additional, Nonen, Shinpei, additional, Furukawa, Mitsugi, additional, Otani, Yasushi, additional, Minami, Toshiyuki, additional, Takahashi, Ryo, additional, Hirata, Haruhiko, additional, Nagatomo, Izumi, additional, Takeda, Yoshito, additional, Kida, Hiroshi, additional, Goya, Sho, additional, Fujio, Yasushi, additional, Azuma, Junichi, additional, Tachibana, Isao, additional, and Kawase, Ichiro, additional

Published
2011
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47. Two cases of leptomeningeal metastases from lung adenocarcinoma which progressed during gefitinib therapy but responded to erlotinib

Author

Tetsumoto, Satoshi, primary, Osa, Akio, additional, Kijima, Takashi, additional, Minami, Toshiyuki, additional, Hirata, Haruhiko, additional, Takahashi, Ryo, additional, Kuhara, Hanako, additional, Nagatomo, Izumi, additional, Takeda, Yoshito, additional, Kida, Hiroshi, additional, Goya, Sho, additional, Tachibana, Isao, additional, and Kawase, Ichiro, additional

Published
2011
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50. Apoptotic Cells Activate NKT Cells through T Cell Ig-Like Mucin-Like–1 Resulting in Airway Hyperreactivity

Author

Lee, Hyun-Hee, primary, Meyer, Everett H., additional, Goya, Sho, additional, Pichavant, Muriel, additional, Kim, Hye Young, additional, Bu, Xia, additional, Umetsu, Sarah E., additional, Jones, Jennifer C., additional, Savage, Paul B., additional, Iwakura, Yoichiro, additional, Casasnovas, Jose M., additional, Kaplan, Gerardo, additional, Freeman, Gordon J., additional, DeKruyff, Rosemarie H., additional, and Umetsu, Dale T., additional

Published
2010
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