618 results on '"Govender, Nelesh"'
Search Results
2. Case Report of Nasal Rhinosporidiosis in South Africa
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Mayet, Huzaifah, Reddy, Denasha L., Alvarez, Tika Bello, Atiya, Yahya, Govender, Nelesh P., Birkhead, Monica, Maphanga, Tsidiso, and Pather, Sugeshnee
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Health - Abstract
A 24-year-old Black woman from South Africa sought care at a local primary-level clinic in Soweto, Johannesburg, South Africa, reporting a painless nasal mass of 3 years duration that caused [...]
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- 2024
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3. Invasive candidiasis
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Lass-Flörl, Cornelia, Kanj, Souha S., Govender, Nelesh P., Thompson, III, George R., Ostrosky- Zeichner, Luis, and Govrins, Miriam Alisa
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- 2024
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4. WHO global research priorities for antimicrobial resistance in human health
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Aanensen, David, Alanio, Alexandre, Alastruey-Izquierdo, Ana, Alemayehu, Tinsae, Al-Hasan, Majdi, Allegaert, Karel, Al-Maani, Amal Saif, Al-Salman, Jameela, Alshukairi, Abeer Nizar, Amir, Afreenish, Applegate, Tanya, Araj, George F, Villalobos, Marlen Arce, Årdal, Christine, Ashiru-Oredope, Diane, Ashley, Elizabeth A, Babin, François-Xavier, Bachmann, Laura H, Bachmann, Till, Baker, Kate Susan, Balasegaram, Manica, Bamford, Colleen, Baquero, Fernando, Barcelona, Laura Isabel, Bassat, Quique, Bassetti, Matteo, Basu, Sulagna, Beardsley, Justin, Vásquez, Grey Benoit, Berkley, James A, Bhatnagar, Anuj K, Bielicki, Julia, Bines, Julie, Bongomin, Felix, Bonomo, Robert A, Bradley, John S, Bradshaw, Catriona, Brett, Ana, Brink, Adrian, Brown, Colin, Brown, Jeremy, Buising, Kirsty, Carson, Carolee, Carvalho, Anna Cristina, Castagnola, Elio, Cavaleri, Marco, Cecchini, Michele, Chabala, Chishala, Chaisson, Richard E, Chakrabarti, Arunaloke, Chandler, Clare, Chandy, Sujith John, Charani, Esmita, Chen, Lisa, Chiara, Francesca, Chowdhary, Anuradha, Chua, Arlene, Chuki, Pem, Chun, Doo Ryeon, Churchyard, Gavin, Cirillo, Daniela, Clack, Lauren, Coffin, Susan E, Cohn, Jennifer, Cole, Michelle, Conly, John, Cooper, Ben, Corso, Alejandra, Cosgrove, Sara E, Cox, Helen, Daley, Charles L, Darboe, Saffiatou, Darton, Tom, Davies, Gerry, de Egea, Viviana, Dedeić-Ljubović, Amela, Deeves, Miranda, Denkinger, Claudia, Dillon, Jo-Anne R, Dramowski, Angela, Eley, Brian, Roberta Esposito, Susanna Maria, Essack, Sabiha Y, Farida, Helmia, Farooqi, Joveria, Feasey, Nicholas, Ferreyra, Cecilia, Fifer, Helen, Finlayson, Heather, Frick, Mike, Gales, Ana Cristina, Galli, Luisa, Gandra, Sumanth, Gerber, Jeffrey S, Giske, Christian, Gordon, Bruce, Govender, Nelesh, Guessennd, Nathalie, Guindo, Ibrehima, Gurbanova, Elmira, Gwee, Amanda, Hagen, Ferry, Harbarth, Stephan, Haze, John, Heim, Jutta, Hendriksen, Rene, Heyderman, Robert Simon, Holt, Kathryn Elizabeth, Hönigl, Martin, Hook, Edward W, Hope, William, Hopkins, Heidi, Hughes, Gwenda, Ismail, Ghada, Issack, Mohammad Iqbal, Jacobs, Jan, Jasovský, Dušan, Jehan, Fyeza, Pearson, Antonieta Jimenez, Jones, Makoto, Joshi, Mohan P, Kapil, Arti, Kariuki, Samuel, Karkey, Abhilasha, Kearns, Gregory L, Keddy, Karen Helena, Khanna, Nina, Kitamura, Akiko, Kolho, Kaija-Leena, Kontoyiannis, Dimitrios P, Kotwani, Anita, Kozlov, Roman S, Kranzer, Katharina, Kularatne, Ranmini, Lahra, Monica M, Langford, Bradley J, Laniado-Laborin, Rafael, Larsson, Joakim, Lass-Flörl, Cornelia, Le Doare, Kirsty, Lee, Hyukmin, Lessa, Fernanda, Levin, Anna S, Limmathurotsakul, Direk, Lincopan, Nilton, Lo Vecchio, Andrea, Lodha, Rakesh, Loeb, Mark, Longtin, Yves, Lye, David Chien, Mahmud, Asif Mujtaba, Manaia, Célia, Manderson, Lenore, Mareković, Ivana, Marimuthu, Kalisvar, Martin, Irene, Mashe, Tapfumanei, Mei, Zeng, Meis, Jacques F, Lyra Tavares De Melo, Flávio Augusto, Mendelson, Marc, Miranda, Angelica Espinosa, Moore, David, Morel, Chantal, Moremi, Nyambura, Moro, Maria Luisa, Moussy, Francis, Mshana, Stephen, Mueller, Arno, Ndow, Francis J, Nicol, Mark, Nunn, Andrew, Obaro, Stephen, Obiero, Christina W, Okeke, Iruka N, Okomo, Uduak, Okwor, Tochi J, Oladele, Rita, Omulo, Sylvia, Ondoa, Pascale, Ortellado de Canese, Juana Medarda, Ostrosky-Zeichner, Luis, Padoveze, Maria Clara, Pai, Madhukar, Park, Benjamin, Parkhill, Julian, Parry, Christopher M, Peeling, Rosanna, Sobreira Vieira Peixe, Luísa Maria, Perovic, Olga, Pettigrew, Melinda M, Principi, Nicola, Pulcini, Céline, Puspandari, Nelly, Rawson, Timothy, Reddy, Denasha Lavanya, Reddy, Kessendri, Redner, Paulo, Rodríguez Tudela, Juan Luis, Rodríguez-Baño, Jesús, Van Katwyk, Susan Rogers, Roilides, Emmanuel, Rollier, Christine, Rollock, Leslie, Ronat, Jean-Baptiste, Ruppe, Etienne, Sadarangani, Manish, Salisbury, David, Salou, Mounerou, Samison, Luc Hervé, Sanguinetti, Maurizio, Sartelli, Massimo, Schellack, Natalie, Schouten, Jeroen, Schwaber, Mitchell J, Seni, Jeremiah, Senok, Abiola, Shafer, William M, Shakoor, Sadia, Sheppard, Donald, Shin, Jong-Hee, Sia, Sonia, Sievert, Dawn, Singh, Ishwar, Singla, Rupak, Skov, Robert Leo, Soge, Olusegun O, Sprute, Rosanne, Srinivasan, Arjun, Srinivasan, Subasree, Sundsfjord, Arnfinn, Tacconelli, Evelina, Tahseen, Sabira, Tangcharoensathien, Viroj, Tängdén, Thomas, Thursky, Karin, Thwaites, Guy, Tigulini de Souza Peral, Renata, Tong, Deborah, Tootla, Hafsah Deepa, Tsioutis, Constantinos, Turner, Katy M, Turner, Paul, Omar, Shaheed Vally, van de Sande, Wendy WJ, van den Hof, Susan, van Doorn, Rogier, Veeraraghavan, Balaji, Verweij, Paul, Wahyuningsih, Retno, Wang, Hui, Warris, Adilia, Weinstock, Hillard, Wesangula, Evelyn, Whiley, David, White, Peter J, Williams, Phoebe, Xiao, Yonghong, Moscoso, Martin Yagui, Yang, Hsu Li, Yoshida, Sachiyo, Yu, Yunsong, Żabicka, Dorota, Zignol, Matteo, Rudan, Igor, Bertagnolio, Silvia, Dobreva, Zlatina, Centner, Chad M, Olaru, Ioana Diana, Donà, Daniele, Burzo, Stefano, Huttner, Benedikt D, Chaillon, Antoine, Gebreselassie, Nebiat, Wi, Teodora, Hasso-Agopsowicz, Mateusz, Allegranzi, Benedetta, Sati, Hatim, Ivanovska, Verica, Kothari, Kavita U, Balkhy, Hanan H, Cassini, Alessandro, Hamers, Raph L, and Weezenbeek, Kitty Van
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- 2024
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5. Prospective antimicrobial stewardship interventions by multidisciplinary teams to reduce neonatal antibiotic use in South Africa: The Neonatal Antimicrobial Stewardship (NeoAMS) study
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Dramowski, Angela, Prusakov, Pavel, Goff, Debra A., Brink, Adrian, Govender, Nelesh P., Annor, Ama Sakoa, Balfour, Liezl, Bekker, Adrie, Cassim, Azraa, Gijzelaar, Michelle, Holgate, Sandi L., Kolman, Sonya, Messina, Angeliki, Tootla, Hafsah, Schellack, Natalie, van Jaarsveld, Andriette, Reddy, Kessendri, Pillay, Shakti, Conradie, Lucinda, van Niekerk, Anika M., Bester, Tarina, Alexander, Pearl, Andrews, Antoinette, Dippenaar, Magdel, Bamford, Colleen, Brits, Sharnel, Chirwa, Pinky, Erasmus, Hannelie, Ekermans, Pieter, Gounden, Pebenita, Kriel, Teresa, Mawela, Dini, Moncho, Masego, Mphuthi, Tonia, Nhari, Ronald, Charani, Esmita, Sánchez, Pablo J., and Bergh, Dena van den
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- 2024
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6. Candida auris Clinical Isolates Associated with Outbreak in Neonatal Unit of Tertiary Academic Hospital, South Africa
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Kekana, Dikeledi, Naicker, Serisha D., Shuping, Liliwe, Velaphi, Sithembiso, Nakwa, Firdose L., Wadula, Jeannette, and Govender, Nelesh P.
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Nucleotide sequencing -- Health aspects ,Genomics -- Health aspects ,DNA sequencing -- Health aspects ,Fluconazole -- Health aspects ,Genomes -- Health aspects ,Infection -- Health aspects ,Epidemiology -- Health aspects ,Infants (Newborn) -- Health aspects ,Caspofungin -- Health aspects ,Health - Abstract
Candida auris is a multidrug-resistant yeast that causes invasive infections with high associated mortality in acute and long-term healthcare facilities worldwide (2,2). Although C. auris was initially described in 2009 [...]
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- 2023
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7. High Prevalence of Candida auris Colonization during Protracted Neonatal Unit Outbreak, South Africa
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Shuping, Liliwe, Maphanga, Tsidiso G., Naicker, Serisha D., Mpembe, Ruth, Ngoma, Nqobile, Velaphi, Sithembiso, Nakwa, Firdose, Wadula, Jeannette, Jaglal, Prenika, and Govender, Nelesh P.
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Infection ,Infants (Newborn) ,Health - Abstract
Candida auris has been recognized as a critical priority pathogen globally, causing invasive infections and persistent outbreaks in healthcare facilities (1). In June 2019, an outbreak dominated by C. auris [...]
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- 2023
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8. Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM
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Chang, Christina C, Harrison, Thomas S, Bicanic, Tihana A, Chayakulkeeree, Methee, Sorrell, Tania C, Warris, Adilia, Hagen, Ferry, Spec, Andrej, Oladele, Rita, Govender, Nelesh P, Chen, Sharon C, Mody, Christopher H, Groll, Andreas H, Chen, Yee-Chun, Lionakis, Michail S, Alanio, Alexandre, Castañeda, Elizabeth, Lizarazo, Jairo, Vidal, José E, Takazono, Takahiro, Hoenigl, Martin, Alffenaar, Jan-Willem, Gangneux, Jean-Pierre, Soman, Rajeev, Zhu, Li-Ping, Bonifaz, Alexandro, Jarvis, Joseph N, Day, Jeremy N, Klimko, Nikolai, Salmanton-García, Jon, Jouvion, Grégory, Meya, David B, Lawrence, David, Rahn, Sebastian, Bongomin, Felix, McMullan, Brendan J, Sprute, Rosanne, Nyazika, Tinashe K, Beardsley, Justin, Carlesse, Fabianne, Heath, Christopher H, Ayanlowo, Olusola O, Mashedi, Olga M, Queiroz-Telles Filho, Flavio, Hosseinipour, Mina C, Patel, Atul K, Temfack, Elvis, Singh, Nina, Cornely, Oliver A, Boulware, David R, Lortholary, Olivier, Pappas, Peter G, and Perfect, John R
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- 2024
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9. Impact of prior cryptococcal antigen screening on in-hospital mortality in cryptococcal meningitis or fungaemia among HIV-seropositive individuals in South Africa: a cross-sectional observational study
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Abrahams, Shareef, Ahmed, Khatija, Avenant, Theunis, Bamford, Colleen, Bhola, Prathna, Bishop, Kate, Black, John, Blumberg, Lucille, Bosman, Norma, Botha, Maria, Brink, Adrian, Budavari, Suzy, Burra, Asmeeta, Chibabhai, Vindana, Chomba, Rispah, Cohen, Cheryl, Coovadia, Yacoob, Crowther-Gibson, Penny, Dawood, Halima, de Gouveia, Linda, Dlamini, Nomonde, Dlamini, Siyanda, Dreyer, Andries, du Plessis, Nicolette, du Plessis, Erna, du Plessis, Mignon, Erasmus, Linda, Feldman, Charles, Govender, Nelesh, Govind, Chetna, Groome, Michelle, Haffejee, Sumayya, Hamese, Ken, Haumann, Carel, Hoho, Nombulelo, Hoosen, Anwar, Hoosien, Ebrahim, Howell, Victoria, Hoyland, Greta, Ismail, Farzana, Ismail, Husna, Ismail, Nazir, Ive, Prudence, Jooste, Pieter, Karstaedt, Alan, Khantsi, Ignatius, Kleinhans, Vicky, Kleynhans, Jackie, Kolojane, Molebogeng, Kufa-Chakezha, Tendesayi, Lebaka, Tiisetso, Lebudi, Jacob, Legare, Neo, Lekalakala, Ruth, Lindeque, Kathy, Lowman, Warren, Madhi, Shabir, Magobo, Rindidzani, Mahabeer, Prasha, Maharaj, Adhil, Makgoba, Martha, Maloba, Molatji, Maluleka, Caroline, Manaka, Mokupi, Mangena, Phetho, Maningi, Nontuthuko, Marcus, Louis, Marshall, Terry, Mathebula, Rudzani, Mathunjwa, Azwifarwi, Mbelle, Nontombi, Mbuthu, Bongani, McCarthy, Kerrigan, Meiring, Susan, Mekgoe, Omphile, Menezes, Colin, Miller, Cecilia, Mlisana, Koleka, Moncho, Masego, Moore, David, Moremi, Myra, Morris, Lynn, Moshe, Moamokgethi, Mothibi, Lesego, Moultrie, Harry, Mpembe, Ruth, Mutevedzi, Portia, Mwansa-Kambafwile, Judith, Naby, Fathima, Naicker, Preneshni, Naidoo, Romola, Nana, Trusha, Nchabeleng, Maphoshane, Ndlovu, Phathutshedzo, Nel, Jeremy, Ngomane, Mimmy, Ngubane, Wendy, Nicol, Mark, Njikho, Sunnieboy, Ntlemo, Grace, Ntuli, Sindi, Page, Nicola, Paulse, Nuraan, Pearce, Vanessa, Perovic, Olga, Pillay, Keshree, Pombo, Dina, Poswa, Xoliswa, Prentice, Elizabeth, Puren, Adrian, Quan, Vanessa, Ramjathan, Praksha, Ramkillawan, Yeishna, Reddy, Kessendri, Reubenson, Gary, Richards, Lauren, Said, Mohammed, Samodien, Nazlee, Samuel, Catherine, Seetharam, Sharona, Sekwadi, Phuti, Selekisho, Mirriam, Senekal, Marthinus, Shuping, Liliwe, Sibiya, Ngoaka, Sirkar, Surendra, Smit, Juanita, Smith, Anthony, Smith, Marshagne, Sookan, Lisha, Sriruttan, Charlotte, Stacey, Sarah, Swe Han, Khine Swe, Thomas, Teena, Thomas, Juno, Tsisti, Merika, van Schalkwyk, Erika, Variava, Ebrahim, Vazi, Phumeza, Verwey, Charl, von Gottberg, Anne, Wadula, Jeanntte, Walaza, Sibongile, Wende, Linda, Whitelaw, Andrew, Wilson, Douglas, Zietsman, Inge, Paccoud, Olivier, Mashau, Rudzani, Greene, Greg, and Govender, Nelesh P.
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- 2023
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10. Post-mortem investigation of deaths due to pneumonia in children aged 1–59 months in sub-Saharan Africa and South Asia from 2016 to 2022: an observational study
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Adam, Yasmin, Agaya, Janet, Ahmed, A.S.M. Nawshad Uddin, Ahmed, Dilruba, Alemu, Addisu, Ali, Solomon, Ameh, Soter, Aol, George, Argeseanu, Solveig, Ariuman, Farida, Balogun, Oluseyi, Bari, Sanwarul, Basket, Margaret, Begum, Ferdousi, Bhandari, Manu, Blevins, John, Bunn, James, Bursuc, Courtney, Cain, Carrie Jo, Chawana, Richard, Chawla, Kiranpreet, Chukwuegbo, Cornell, Diarra, Kounandji, Diarra, Tiéman, Diaz, Maureen, Duduyemi, Babatunde, Fairchild, Karen D., Flora, Meerjady Sabrina, Fritz, Ashleigh, Garel, Mischka, Gaume, Brigitte, Gizaw, Mahlet Abayneh, Govender, Nelesh P., Greene, Carol L., Gure, Tadesse, Halu, Binyam, Hoque, Mahbubul, Hwinya, Cleopas, Ibrahim, Alexander M., Igunza, Kitiezo Aggrey, Islam, Ferdousi, Ita, Okokon, Jambai, Amara, Johnson, J. Kristie, Juma, Jane, Kaluma, Erick, Kamal, Mohammed, Kaykay, Osman, Kenneh, Sartie, Khagayi, Sammy, Koka, Rima, Kone, Diakaridia, Koplan, Jeffrey P., Kourouma, Nana, Kowuor, Dickens, LaHatte, Kristin, Lala, Sanjay G., Lee, Kyu Han, Liu, Lucy, Lombaard, Hennie, Maixenchs, Maria, Manhique, Zara, Mannah, Margaret, Martines, Roosecelis, Mash, Ronald, Mehta, Ashka, Menéndez, Clara, Misore, Thomas, Mocumbi, Sibone, Moseray, Andrew, Moses, Francis, Muga, Christopher, Munguambe, Khátia, Myburgh, Nellie, Nair, Shailesh, Ndagurwa, Pedzisai, Nhacolo, Ariel, Nhampossa, Tacilta, Nwajiobi, Princewill, Ochola, Christine, Oliech, Richard, Oluoch, Bernard, Onwuchekwa, Uma U., Onyango, Peter Nyamthimba, Orlien, Stian MS, Otieno, Peter, Oundo, Joseph, Owuor, Harun, Parveen, Shahana, Petersen, Karen, Pratt, Samuel, Rahman, Mahbubur, Rahman, Mohammad Mosiur, Rahman, Mustafizur, Raymer, Sarah, Ritter, Jana, Salzberg, Navit T., Samura, Solomon, Sannoh, Sulaiman, Sanogo, Doh, Seppeh, Martin, Sesay, Tom, Sesay, Joseph Kamanda, Shirin, Tahmina, Sissoko, Seydou, Smart, Francis, Sorour, Gillian, Squire, James, Swaray-Deen, Alim, Swart, Peter J., Tarawally, Fatmata Bintu, Tasnim, Saria, Temesgen, Fikremelekot, Tennant, Sharon M., Traore, Cheick Bougadari, Traore, Awa, Velaphi, Sithembiso, Vyas, Kurt, Wadhwa, Ashutosh, Wadula, Jeannette, Waller, Jessica, Wanga, Valentine, Warang, Shamta, Were, Joyce Akinyi, Wilson, Tais, Winchell, Jonas, Wise, Amy, Witherbee, Jakob, Yeshi, Melisachew Mulatu, Zaman, K., Mahtab, Sana, Blau, Dianna M, Madewell, Zachary J, Ogbuanu, Ikechukwu, Ojulong, Julius, Lako, Sandra, Legesse, Hailemariam, Bangura, Joseph S, Bassat, Quique, Mandomando, Inacio, Xerinda, Elisio, Fernandes, Fabiola, Varo, Rosauro, Sow, Samba O, Kotloff, Karen L, Tapia, Milagritos D, Keita, Adama Mamby, Sidibe, Diakaridia, Onyango, Dickens, Akelo, Victor, Gethi, Dickson, Verani, Jennifer R, Revathi, Gunturu, Scott, J Anthony G, Assefa, Nega, Madrid, Lola, Bizuayehu, Hiwot, Tirfe, Tseyon Tesfaye, El Arifeen, Shams, Gurley, Emily S, Islam, Kazi Munisul, Alam, Muntasir, Zahid Hossain, Mohammad, Dangor, Ziyaad, Baillie, Vicky L, Hale, Martin, Mutevedzi, Portia, Breiman, Robert F, Whitney, Cynthia G, and Madhi, Shabir A
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- 2024
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11. Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology
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Thompson, George R, Le, Thuy, Chindamporn, Ariya, Kauffman, Carol A, Alastruey-Izquierdo, Ana, Ampel, Neil M, Andes, David R, Armstrong-James, Darius, Ayanlowo, Olusola, Baddley, John W, Barker, Bridget M, Lopes Bezerra, Leila, Buitrago, Maria J, Chamani-Tabriz, Leili, Chan, Jasper FW, Chayakulkeeree, Methee, Cornely, Oliver A, Cunwei, Cao, Gangneux, Jean-Pierre, Govender, Nelesh P, Hagen, Ferry, Hedayati, Mohammad T, Hohl, Tobias M, Jouvion, Grégory, Kenyon, Chris, Kibbler, Christopher C, Klimko, Nikolai, Kong, David CM, Krause, Robert, Lee Lee, Low, Meintjes, Graeme, Miceli, Marisa H, Rath, Peter-Michael, Spec, Andrej, Queiroz-Telles, Flavio, Variava, Ebrahim, Verweij, Paul E, Schwartz, Ilan S, and Pasqualotto, Alessandro C
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Infectious Diseases ,Prevention ,Emerging Infectious Diseases ,Vaccine Related ,Biodefense ,Infection ,Good Health and Well Being ,Animals ,Clinical Decision-Making ,Consensus ,Endemic Diseases ,Europe ,Global Health ,Guidelines as Topic ,Humans ,International Cooperation ,Mycoses ,Risk Factors ,Clinical Sciences ,Medical Microbiology ,Public Health and Health Services ,Microbiology - Abstract
The global burden of the endemic mycoses (blastomycosis, coccidioidomycosis, emergomycosis, histoplasmosis, paracoccidioidomycosis, sporotrichosis, and talaromycosis) continues to rise yearly and these infectious diseases remain a leading cause of patient morbidity and mortality worldwide. Management of the associated pathogens requires a thorough understanding of the epidemiology, risk factors, diagnostic methods and performance characteristics in different patient populations, and treatment options unique to each infection. Guidance on the management of these infections has the potential to improve prognosis. The recommendations outlined in this Review are part of the "One World, One Guideline" initiative of the European Confederation of Medical Mycology. Experts from 23 countries contributed to the development of these guidelines. The aim of this Review is to provide an up-to-date consensus and practical guidance in clinical decision making, by engaging physicians and scientists involved in various aspects of clinical management.
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- 2021
12. 'Cryptococcus neoformans': Diagnostic dilemmas, electron microscopy and capsular variants
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Birkhead, Monica, Naicker, Serisha D, Blasich, Nozuko P, Rukasha, Ivy, Thomas, Juno, Sriruttan, Charlotte, Abrahams, Shareef, Mavuso, Grisselda S, and Govender, Nelesh P
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- 2019
13. Fungal diseases in Africa: Closing the gaps in diagnosis and treatment through implementation research and advocacy
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Bongomin, Felix, Ekeng, Bassey E., Kwizera, Richard, Salmanton-García, Jon, Kibone, Winnie, van Rhijn, Norman, Govender, Nelesh P., Meya, David B., Osaigbovo, Iriagbonse I., Hamer, Davidson H., Oladele, Rita, and Denning, David W.
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- 2023
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14. HIV and fungal priority pathogens
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Sati, Hatim, Alastruey-Izquierdo, Ana, Perfect, John, Govender, Nelesh P, Harrison, Tom S, Chiller, Tom, Sorrell, Tania C, Bongomin, Felix, Oladele, Rita, Chakrabarti, Arunaloke, Wahyuningsih, Retno, Colombo, Arnaldo Lopes, Rodriguez-Tudela, Juan Luis, Beyrer, Chris, and Ford, Nathan
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- 2023
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15. Provider adherence to clinical care recommendations for infants and children who died in seven low- and middle-income countries in the Child Health and Mortality Prevention Surveillance (CHAMPS) network
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Solomon, Fatima, Sorour, Gillian, Lombaard, Hennie, Wadula, Jeannette, Petersen, Karen, Hale, Martin, Govender, Nelesh P., Swart, Peter J., Lala, Sanjay G., Velaphi, Sithembiso, Chawana, Richard, Adam, Yasmin, Wise, Amy, Fritz, Ashleigh, Myburgh, Nellie, Ndagurwa, Pedzisai, Hwinya, Cleopas, Bari, Sanwarul, Parveen, Shahana, Kamal, Mohammed, Uddin Ahmed, A.S.M. Nawshad, Hoque, Mahbubul, Tasnim, Saria, Islam, Ferdousi, Ariuman, Farida, Rahman, Mohammad Mosiur, Begum, Ferdousi, Zaman, K., Rahman, Mustafizur, Ahmed, Dilruba, Flora, Meerjady Sabrina, Shirin, Tahmina, Rahman, Mahbubur, Oundo, Joseph, Ibrahim, Alexander M., Temesgen, Fikremelekot, Gure, Tadesse, Alemu, Addisu, Yeshi, Melisachew Mulatu, Gizaw, Mahlet Abayneh, Orlien, Stian, Ali, Solomon, Otieno, Peter, Onyango, Peter Nyamthimba, Agaya, Janet, Oliech, Richard, Were, Joyce Akinyi, Gethi, Dickson, Khagayi, Sammy, Aol, George, Misore, Thomas, Owuor, Harun, Mugah, Christopher, Oluoch, Bernard, Ochola, Christine, Tennant, Sharon M., Greene, Carol L., Mehta, Ashka, Johnson, J. Kristie, Gaume, Brigitte, Koka, Rima, Fairchild, Karen D., Kone, Diakaridia, Sanogo, Doh, Onwuchekwa, Uma U., Kourouma, Nana, Sissoko, Seydou, Traore, Cheick Bougadari, Juma, Jane, Diarra, Kounandji, Traore, Awa, Diarra, Tiéman, Chawla, Kiranpreet, Nhampossa, Tacilta, Manhique, Zara, Mocumbi, Sibone, Menéndez, Clara, Munguambe, Khátia, Nhacolo, Ariel, Maixenchs, Maria, Moseray, Andrew, Tarawally, Fatmata Bintu, Seppeh, Martin, Mash, Ronald, Ojulong, Julius, Duduyemi, Babatunde, Bunn, James, Swaray-Deen, Alim, Bangura, Joseph, Jambai, Amara, Mannah, Margaret, Ita, Okokon, Chukwuegbo, Cornell, Sannoh, Sulaiman, Nwajiobi, Princewill, Kowuor, Dickens, Kaluma, Erick, Balogun, Oluseyi, Samura, Solomon, Pratt, Samuel, Moses, Francis, Sesay, Tom, Squire, James, Sesay, Joseph Kamanda, Kaykay, Osman, Halu, Binyam, Legesse, Hailemariam, Smart, Francis, Kenneh, Sartie, Ameh, Soter, Ritter, Jana, Wilson, Tais, Winchell, Jonas, Witherbee, Jakob, Salzberg, Navit T., Koplan, Jeffrey P., Basket, Margaret, Wadhwa, Ashutosh, Lee, Kyu Han, Wanga, Valentine, Martines, Roosecelis, Warang, Shamta, Diaz, Maureen, Waller, Jessica, Nair, Shailesh, Liu, Lucy, Bursuc, Courtney, LaHatte, Kristin, Raymer, Sarah, Blevins, John, Argeseanu, Solveig, Vyas, Kurt, Bhandari, Manu, Rees, Chris A., Igunza, Kitiezo Aggrey, Madewell, Zachary J., Akelo, Victor, Onyango, Dickens, El Arifeen, Shams, Gurley, Emily S., Hossain, Mohammad Zahid, Rahman, Afruna, Alam, Muntasir, Scott, J. Anthony G., Assefa, Nega, Madrid, Lola, Belachew, Anteneh, Leulseged, Haleluya, Kotloff, Karen L., Sow, Samba O., Tapia, Milagritos D., Keita, Adama Mamby, Sidibe, Diakaridia, Sitoe, Antonio, Varo, Rosauro, Ajanovic, Sara, Bassat, Quique, Mandomando, Inácio, Tippett Barr, Beth A., Ogbuanu, Ikechukwu, Cain, Carrie Jo, Bassey, Ima-Abasi, Luke, Ronita, Gassama, Khadija, Madhi, Shabir, Dangor, Ziyaad, Mahtab, Sana, du Toit, Jeanie, Mutevedzi, Portia C., Blau, Dianna M., Breiman, Robert F., and Whitney, Cynthia G.
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- 2023
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16. Bacterial and Candida Colonization of Neonates in a Regional Hospital in South Africa
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Mabena, Fikile C., Olwagen, Courtney P., Phosa, Matshie, Ngwenya, Innocent K., Van der Merwe, Lara, Khan, Aaliyah, Mwamba, Tshiama M., Mpembe, Ruth, Magobo, Rindidzani E., Govender, Nelesh P., Velaphi, Sithembiso C., and Madhi, Shabir A.
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- 2023
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17. Diagnostic capacity for invasive fungal infections in advanced HIV disease in Africa: a continent-wide survey
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Lakoh, Sulaiman, Kamudumuli, Pocha Samuel, Penney, Richard O S, Haumba, Samson M, Jarvis, Joseph N, Hassan, Asha Jama, Moudoute, Ngando Laure E, Ocansey, Bright K, Izco, Santiago, Kipkerich, Stephen, Sacarlal, Jahit, Awopeju, Abimbola T, Govender, Nelesh P, Munyanji, Cleophas If Malaba, Guyguy, Kamwiziku, Orefuwa, Emma, and Denning, David W
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- 2023
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18. Review: Emergomycosis
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Reddy, Denasha L., Nel, Jeremy, and Govender, Nelesh P.
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- 2023
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19. The global burden of HIV-associated cryptococcal infection in adults in 2020: a modelling analysis
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Rajasingham, Radha, Govender, Nelesh P, Jordan, Alexander, Loyse, Angela, Shroufi, Amir, Denning, David W, Meya, David B, Chiller, Tom M, and Boulware, David R
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- 2022
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20. Outcomes of flucytosine-containing combination treatment for cryptococcal meningitis in a South African national access programme: a cross-sectional observational study
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Abrahams, Shareef, Pearce, Vanessa, Moncho, Masego, Wadula, Jeanette, Maloba, Motlatji, Hoosen, Anwar, Verwey, Charl, Menezes, Colin, Moore, David, Pombo, Dina, Reubenson, Gary, Ntlemo, Grace, Richards, Lauren, Nchabeleng, Maphoshane, Tsitsi, Merika, Moshe, Moamokgethi, Said, Mohammed, Kolojane, Molebogeng, Mothibi, Lesego, Du Plessis, Nicolette, Chomba, Rispah, Thomas, Teena, Avenant, Theunis, Nana, Trusha, Chibabhai, Vindana, Maharj, Adhil, Wilson, Douglas, Naby, Fathima, Dawood, Halima, Han, Khine Swe Swe, Sookan, Lisha, Dlamini, Nomonde, Ramajathan, Praksha, Mahabeer, Prasha, Bhola, Prathna, Naidoo, Romola, Haffejee, Sumayya, Sirkar, Surendra, Ramkillawan, Yeishna, Hamese, Ken, Sibiya, Ngoaka, Mangena, Phetho, Lekalakala, Ruth, Hoyland, Greta, Ntuli, Sindi, Variava, Ebrahim, Khantsi, Ignatius, Mekgoe, Omphile, Brink, Adrian, Prentice, Elizabeth, Reddy, Kessendri, Whitelaw, Andrew, Hoosien, Ebrahim, Zietsman, Inge, Marshall, Terry, Poswa, Xoliswa, Govind, Chetna, Smit, Juanita, Pillay, Keshree, Seetharam, Sharona, Howell, Victoria, Samuel, Catherine, Senekal, Marthinus, Bamford, Colleen, Dreyer, Andries, Marcus, Louis, Lowman, Warren, von Gottberg, Anne, Smith, Anthony, Mathunjwa, Azwifarwi, d'Abreu, Cecilia, Miller, Cecilia, Cohen, Cheryl, Ismail, Farzana, Moultrie, Harry, Ismail, Husna, Weyer, Jacqueline, Kleynhans, Jackie, Rossouw, Jenny, Frean, John, Ebonwu, Joy, Mwansa-Kambafwile, Judith, Thomas, Juno, Bishop, Kate, McCarthy, Kerrigan, Shuping, Liliwe, de Gouveia, Linda, Erasmus, Linda, Puren, Adrian, Blumberg, Lucille, Smith, Marshagne, Makgoba, Martha, Groome, Michelle, du Plessis, Mignon, Ngomane, Mimmy, Manaka, Mokupi, Moremi, Myra, Ismail, Nazir, Legare, Neo, Page, Nicola, Hoho, Nombulelo, Perovic, Olga, Sekwadi, Phuti, Magobo, Rindidzani, Mpembe, Ruth, Walaza, Sibongile, Dlamini, Siyanda, Njikho, Sunnieboy, Lebaka, Tiisetso, Ngubane, Wendy, Mashau, Rudzani C, Meiring, Susan T, Quan, Vanessa C, Nel, Jeremy, Greene, Greg S, Garcia, Andrea, Reddy, Denasha L, Venter, Michelle, Stacey, Sarah, Madua, Matamela, Boretti, Lia, Harrison, Thomas S, Meintjes, Graeme, Shroufi, Amir, Trivino-Duran, Laura, Black, John, and Govender, Nelesh P
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- 2022
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21. Culture-confirmed neonatal bloodstream infections and meningitis in South Africa, 2014–19: a cross-sectional study
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Mashau, Rudzani C, Meiring, Susan T, Dramowski, Angela, Magobo, Rindidzani E, Quan, Vanessa C, Perovic, Olga, von Gottberg, Anne, Cohen, Cheryl, Velaphi, Sithembiso, van Schalkwyk, Erika, and Govender, Nelesh P
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- 2022
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22. Demographic and pathogen characteristics of incident bacterial meningitis in infants in South Africa: A cohort study.
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Kiakuvue, Yannick Nkiambi, Mall, Sumaya, Govender, Nelesh, Gottberg, Anne von, Mashau, Rudzani, Meiring, Susan, and Cohen, Cheryl
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BACTERIAL meningitis ,STREPTOCOCCUS agalactiae ,VERTICAL transmission (Communicable diseases) ,AGE groups ,SOUTH Africans ,HAEMOPHILUS influenzae - Abstract
Introduction: Bacterial meningitis is a major cause of death, with an approximate case fatality rate of 37% across all age groups in South Africa. This study aimed to describe the demographic and pathogen characteristics of incident meningitis in children aged <1 year in South Africa from 2014 through 2018, during a period when Haemophilus influenzae type b vaccine and pneumococcal conjugate vaccines (PCV) were both included in the expanded program on immunization (EPI). Methods: We conducted a cohort study of routine laboratory data in the National Health Laboratory Service Corporate Data Warehouse, which covers approximately 80% of the South African population. We defined a case of laboratory-confirmed bacterial meningitis as any person aged <1 year with meningitis diagnosed by culture and identification of a pathogen documented as being a common cause of meningitis in CSF. The cause-specific incidence risks were calculated by dividing the number of positive specimens in each age group and year by the corresponding mid-year population for children under 1 year old and those in the post-neonatal period (≥ 28 days to 365 days old). For children under 28 days old, the annual numbers of registered livebirths were used. We used Poisson regression to compare the incidence of meningitis by year. Results: We identified 3575 (1.5%) cases of culture-confirmed bacterial meningitis from the 232,016 cerebrospinal fluid (CSF) specimens tested from 2014–2018. The highest number of cases were recorded in children aged <28 days (1873, 52.4%), male children (1800, 50.4%) as well as in the Gauteng Province (2014, 56.3%). Acinetobacter baumannii (14.9%), followed by Klebsiella pneumoniae (13.5%), and group B streptococcus (GBS) (10.7%), were the most common pathogens detected. Overall, A. baumannii had the highest incidence risk, occurring at 9.8 per 100,000 persons in children aged <1 year in 2018. Among neonates, A. baumannii peaked at 14.9 per 100,000 livebirths in 2018, while Streptococcus pneumoniae was most common in the post-neonatal period (≥ 28 days to 365 days old), peaking at 9.8 per 100,000 persons in 2014. There was an increase in the annual incidence of most pathogens over the study period. Conclusion: There was an increasing trend in the annual incidence of bacterial meningitis in infants caused by most pathogens, particularly A. baumannii, K. pneumoniae and GBS. In addition to increased uptake of vaccination, prevention measures to reduce nosocomial and mother-to-child transmission of bacteria could include antenatal screening for GBS in pregnant women, rigorous hygiene in the hospital environment as well as rational antibiotic use. [ABSTRACT FROM AUTHOR]
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- 2024
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23. Global guideline for the diagnosis and management of rare yeast infections: an initiative of the ECMM in cooperation with ISHAM and ASM
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Chen, Sharon C-A, Perfect, John, Colombo, Arnaldo L, Cornely, Oliver A, Groll, Andreas H, Seidel, Danila, Albus, Kerstin, de Almedia, Joao N, Jr, Garcia-Effron, Guillermo, Gilroy, Nicole, Lass-Flörl, Cornelia, Ostrosky-Zeichner, Luis, Pagano, Livio, Papp, Tamas, Rautemaa-Richardson, Riina, Salmanton-García, Jon, Spec, Andrej, Steinmann, Joerg, Arikan-Akdagli, Sevtap, Arenz, Dorothee E, Sprute, Rosanne, Duran-Graeff, Luisa, Freiberger, Tomas, Girmenia, Corrado, Harris, Michelle, Kanj, Souha S, Roudbary, Maryam, Lortholary, Olivier, Meletiadis, Joseph, Segal, Esther, Tuon, Felipe Francisco, Wiederhold, Nathan, Bicanic, Tihana, Chander, Jagdish, Chen, Yee-Chun, Hsueh, Po-Ren, Ip, Margaret, Munoz, Patricia, Spriet, Isabel, Temfack, Elvis, Thompson, Luis, Tortorano, Anna Maria, Velegraki, Aristea, and Govender, Nelesh P
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- 2021
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24. Post-mortem investigation of deaths due to pneumonia in children aged 1–59 months in sub-Saharan Africa and South Asia from 2016 to 2022: an observational study
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Mahtab, Sana, primary, Blau, Dianna M, additional, Madewell, Zachary J, additional, Ogbuanu, Ikechukwu, additional, Ojulong, Julius, additional, Lako, Sandra, additional, Legesse, Hailemariam, additional, Bangura, Joseph S, additional, Bassat, Quique, additional, Mandomando, Inacio, additional, Xerinda, Elisio, additional, Fernandes, Fabiola, additional, Varo, Rosauro, additional, Sow, Samba O, additional, Kotloff, Karen L, additional, Tapia, Milagritos D, additional, Keita, Adama Mamby, additional, Sidibe, Diakaridia, additional, Onyango, Dickens, additional, Akelo, Victor, additional, Gethi, Dickson, additional, Verani, Jennifer R, additional, Revathi, Gunturu, additional, Scott, J Anthony G, additional, Assefa, Nega, additional, Madrid, Lola, additional, Bizuayehu, Hiwot, additional, Tirfe, Tseyon Tesfaye, additional, El Arifeen, Shams, additional, Gurley, Emily S, additional, Islam, Kazi Munisul, additional, Alam, Muntasir, additional, Zahid Hossain, Mohammad, additional, Dangor, Ziyaad, additional, Baillie, Vicky L, additional, Hale, Martin, additional, Mutevedzi, Portia, additional, Breiman, Robert F, additional, Whitney, Cynthia G, additional, Madhi, Shabir A, additional, Adam, Yasmin, additional, Agaya, Janet, additional, Ahmed, A.S.M. Nawshad Uddin, additional, Ahmed, Dilruba, additional, Alemu, Addisu, additional, Ali, Solomon, additional, Ameh, Soter, additional, Aol, George, additional, Argeseanu, Solveig, additional, Ariuman, Farida, additional, Balogun, Oluseyi, additional, Bari, Sanwarul, additional, Basket, Margaret, additional, Begum, Ferdousi, additional, Bhandari, Manu, additional, Blevins, John, additional, Bunn, James, additional, Bursuc, Courtney, additional, Cain, Carrie Jo, additional, Chawana, Richard, additional, Chawla, Kiranpreet, additional, Chukwuegbo, Cornell, additional, Diarra, Kounandji, additional, Diarra, Tiéman, additional, Diaz, Maureen, additional, Duduyemi, Babatunde, additional, Fairchild, Karen D., additional, Flora, Meerjady Sabrina, additional, Fritz, Ashleigh, additional, Garel, Mischka, additional, Gaume, Brigitte, additional, Gizaw, Mahlet Abayneh, additional, Govender, Nelesh P., additional, Greene, Carol L., additional, Gure, Tadesse, additional, Halu, Binyam, additional, Hoque, Mahbubul, additional, Hwinya, Cleopas, additional, Ibrahim, Alexander M., additional, Igunza, Kitiezo Aggrey, additional, Islam, Ferdousi, additional, Ita, Okokon, additional, Jambai, Amara, additional, Johnson, J. Kristie, additional, Juma, Jane, additional, Kaluma, Erick, additional, Kamal, Mohammed, additional, Kaykay, Osman, additional, Kenneh, Sartie, additional, Khagayi, Sammy, additional, Koka, Rima, additional, Kone, Diakaridia, additional, Koplan, Jeffrey P., additional, Kourouma, Nana, additional, Kowuor, Dickens, additional, LaHatte, Kristin, additional, Lala, Sanjay G., additional, Lee, Kyu Han, additional, Liu, Lucy, additional, Lombaard, Hennie, additional, Maixenchs, Maria, additional, Manhique, Zara, additional, Mannah, Margaret, additional, Martines, Roosecelis, additional, Mash, Ronald, additional, Mehta, Ashka, additional, Menéndez, Clara, additional, Misore, Thomas, additional, Mocumbi, Sibone, additional, Moseray, Andrew, additional, Moses, Francis, additional, Muga, Christopher, additional, Munguambe, Khátia, additional, Myburgh, Nellie, additional, Nair, Shailesh, additional, Ndagurwa, Pedzisai, additional, Nhacolo, Ariel, additional, Nhampossa, Tacilta, additional, Nwajiobi, Princewill, additional, Ochola, Christine, additional, Oliech, Richard, additional, Oluoch, Bernard, additional, Onwuchekwa, Uma U., additional, Onyango, Peter Nyamthimba, additional, Orlien, Stian MS, additional, Otieno, Peter, additional, Oundo, Joseph, additional, Owuor, Harun, additional, Parveen, Shahana, additional, Petersen, Karen, additional, Pratt, Samuel, additional, Rahman, Mahbubur, additional, Rahman, Mohammad Mosiur, additional, Rahman, Mustafizur, additional, Raymer, Sarah, additional, Ritter, Jana, additional, Salzberg, Navit T., additional, Samura, Solomon, additional, Sannoh, Sulaiman, additional, Sanogo, Doh, additional, Seppeh, Martin, additional, Sesay, Tom, additional, Sesay, Joseph Kamanda, additional, Shirin, Tahmina, additional, Sissoko, Seydou, additional, Smart, Francis, additional, Sorour, Gillian, additional, Squire, James, additional, Swaray-Deen, Alim, additional, Swart, Peter J., additional, Tarawally, Fatmata Bintu, additional, Tasnim, Saria, additional, Temesgen, Fikremelekot, additional, Tennant, Sharon M., additional, Traore, Cheick Bougadari, additional, Traore, Awa, additional, Velaphi, Sithembiso, additional, Vyas, Kurt, additional, Wadhwa, Ashutosh, additional, Wadula, Jeannette, additional, Waller, Jessica, additional, Wanga, Valentine, additional, Warang, Shamta, additional, Were, Joyce Akinyi, additional, Wilson, Tais, additional, Winchell, Jonas, additional, Wise, Amy, additional, Witherbee, Jakob, additional, Yeshi, Melisachew Mulatu, additional, and Zaman, K., additional
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- 2024
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25. A global call for talaromycosis to be recognised as a neglected tropical disease
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Narayanasamy, Shanti, Dat, Vu Quoc, Thanh, Nguyen Tat, Ly, Vo Trieu, Chan, Jasper Fuk-Woo, Yuen, Kwok-Yung, Ning, Chuanyi, Liang, Hao, Li, Linghua, Chowdhary, Anuradha, Youngchim, Sirida, Supparatpinyo, Khuanchai, Aung, Ne Myo, Hanson, Josh, Andrianopoulos, Alex, Dougherty, John, Govender, Nelesh P, Denning, David W, Chiller, Tom, Thwaites, Guy, van Doorn, H Rogier, Perfect, John, and Le, Thuy
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- 2021
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26. Spinal epidural abscess caused by Aspergillus spp masquerading as spinal tuberculosis in a person with HIV
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Rule, Roxanne, Mitton, Barend, Govender, Nelesh P, Hoffmann, Daniel, and Said, Mohamed
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- 2021
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27. The importation and establishment of community transmission of SARS-CoV-2 during the first eight weeks of the South African COVID-19 epidemic
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McCarthy, Kerrigan M., Tempia, Stefano, Kufa, Tendesayi, Kleynhans, Jackie, Wolter, Nicole, Jassat, Waasila, Ebonwu, Joy, von Gottberg, Anne, Erasmus, Linda, Muchengeti, Mazvita, Walaza, Sibongile, Ntshoe, Genevie, Shonhiwa, Andronica M., Manana, Pinky N., Pillay, Yogan, Moonasar, Devanand, Muthivhi, Tshilidzi, Mngemane, Shadrack, Mlisana, Koleka, Chetty, Kamy, Blumberg, Lucille H., Cohen, Cheryl, and Govender, Nelesh P.
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- 2021
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28. HIV Infection as Risk Factor for Death among Hospitalized Persons with Candidemia, South Africa, 2012-2017
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Govender, Nelesh P., Todd, Jim, Nel, Jeremy, Mer, Mervyn, Karstaedt, Alan, and Cohen, Cheryl
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Sepsis -- Patient outcomes ,Hospital patients -- Statistics ,HIV infection -- Complications and side effects -- Patient outcomes ,Candidiasis -- Patient outcomes ,Health - Abstract
Candida is a common cause of healthcare-associated bloodstream infections in South Africa; the estimated national incidence risk in 2016-2017 was 84 (95% CI 81-86) cases per 100,000 hospital admissions (2). [...]
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- 2021
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29. Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM
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MMB, MMB Medische Staf, Chang, Christina C., Harrison, Thomas S., Bicanic, Tihana A., Chayakulkeeree, Methee, Sorrell, Tania C., Warris, Adilia, Hagen, Ferry, Spec, Andrej, Oladele, Rita, Govender, Nelesh P., Chen, Sharon C., Mody, Christopher H., Groll, Andreas H., Chen, Yee Chun, Lionakis, Michail S., Alanio, Alexandre, Castañeda, Elizabeth, Lizarazo, Jairo, Vidal, José E., Takazono, Takahiro, Hoenigl, Martin, Alffenaar, Jan Willem, Gangneux, Jean Pierre, Soman, Rajeev, Zhu, Li Ping, Bonifaz, Alexandro, Jarvis, Joseph N., Day, Jeremy N., Klimko, Nikolai, Salmanton-García, Jon, Jouvion, Grégory, Meya, David B., Lawrence, David, Rahn, Sebastian, Bongomin, Felix, McMullan, Brendan J., Sprute, Rosanne, Nyazika, Tinashe K., Beardsley, Justin, Carlesse, Fabianne, Heath, Christopher H., Ayanlowo, Olusola O., Mashedi, Olga M., Queiroz-Telles Filho, Flavio, Hosseinipour, Mina C., Patel, Atul K., Temfack, Elvis, Singh, Nina, Cornely, Oliver A., Boulware, David R., Lortholary, Olivier, Pappas, Peter G., Perfect, John R., MMB, MMB Medische Staf, Chang, Christina C., Harrison, Thomas S., Bicanic, Tihana A., Chayakulkeeree, Methee, Sorrell, Tania C., Warris, Adilia, Hagen, Ferry, Spec, Andrej, Oladele, Rita, Govender, Nelesh P., Chen, Sharon C., Mody, Christopher H., Groll, Andreas H., Chen, Yee Chun, Lionakis, Michail S., Alanio, Alexandre, Castañeda, Elizabeth, Lizarazo, Jairo, Vidal, José E., Takazono, Takahiro, Hoenigl, Martin, Alffenaar, Jan Willem, Gangneux, Jean Pierre, Soman, Rajeev, Zhu, Li Ping, Bonifaz, Alexandro, Jarvis, Joseph N., Day, Jeremy N., Klimko, Nikolai, Salmanton-García, Jon, Jouvion, Grégory, Meya, David B., Lawrence, David, Rahn, Sebastian, Bongomin, Felix, McMullan, Brendan J., Sprute, Rosanne, Nyazika, Tinashe K., Beardsley, Justin, Carlesse, Fabianne, Heath, Christopher H., Ayanlowo, Olusola O., Mashedi, Olga M., Queiroz-Telles Filho, Flavio, Hosseinipour, Mina C., Patel, Atul K., Temfack, Elvis, Singh, Nina, Cornely, Oliver A., Boulware, David R., Lortholary, Olivier, Pappas, Peter G., and Perfect, John R.
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- 2024
30. Beyond bacteria: the growing threat of antifungal resistance
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van Rhijn, Norman, Arikan-Akdagli, Sevtap, Beardsley, Justin, Bongomin, Felix, Chakrabarti, Arunaloke, Chen, Sharon C-A, Chiller, Tom, Lopes Colombo, Arnaldo, Govender, Nelesh P, Alastruey-Izquierdo, Ana, Kidd, Sarah E, Lackner, Michaela, Li, Ruoyu, Hagen, Ferry, van Rhijn, Norman, Arikan-Akdagli, Sevtap, Beardsley, Justin, Bongomin, Felix, Chakrabarti, Arunaloke, Chen, Sharon C-A, Chiller, Tom, Lopes Colombo, Arnaldo, Govender, Nelesh P, Alastruey-Izquierdo, Ana, Kidd, Sarah E, Lackner, Michaela, Li, Ruoyu, and Hagen, Ferry
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- 2024
31. Beyond bacteria: the growing threat of antifungal resistance
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MMB Medische Staf, MMB, van Rhijn, Norman, Arikan-Akdagli, Sevtap, Beardsley, Justin, Bongomin, Felix, Chakrabarti, Arunaloke, Chen, Sharon C.A., Chiller, Tom, Lopes Colombo, Arnaldo, Govender, Nelesh P., Alastruey-Izquierdo, Ana, Kidd, Sarah E., Lackner, Michaela, Li, Ruoyu, Hagen, Ferry, MMB Medische Staf, MMB, van Rhijn, Norman, Arikan-Akdagli, Sevtap, Beardsley, Justin, Bongomin, Felix, Chakrabarti, Arunaloke, Chen, Sharon C.A., Chiller, Tom, Lopes Colombo, Arnaldo, Govender, Nelesh P., Alastruey-Izquierdo, Ana, Kidd, Sarah E., Lackner, Michaela, Li, Ruoyu, and Hagen, Ferry
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- 2024
32. WHO global research priorities for antimicrobial resistance in human health
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Bertagnolio, Silvia, Dobreva, Zlatina, Centner, Chad M, Olaru, Ioana Diana, Donà, Daniele, Burzo, Stefano, Huttner, Benedikt D, Chaillon, Antoine, Gebreselassie, Nebiat, Wi, Teodora, Hasso-Agopsowicz, Mateusz, Allegranzi, Benedetta, Sati, Hatim, Ivanovska, Verica, Kothari, Kavita U, Balkhy, Hanan H, Cassini, Alessandro, Hamers, Raph L, Weezenbeek, Kitty Van, Aanensen, David, Alanio, Alexandre, Alastruey-Izquierdo, Ana, Alemayehu, Tinsae, Al-Hasan, Majdi, Allegaert, Karel, Al-Maani, Amal Saif, Al-Salman, Jameela, Alshukairi, Abeer Nizar, Amir, Afreenish, Applegate, Tanya, Araj, George F, Villalobos, Marlen Arce, Årdal, Christine, Ashiru-Oredope, Diane, Ashley, Elizabeth A, Babin, François-Xavier, Bachmann, Laura H, Bachmann, Till, Baker, Kate Susan, Balasegaram, Manica, Bamford, Colleen, Baquero, Fernando, Barcelona, Laura Isabel, Bassat, Quique, Bassetti, Matteo, Basu, Sulagna, Beardsley, Justin, Vásquez, Grey Benoit, Berkley, James A, Bhatnagar, Anuj K, Bielicki, Julia, Bines, Julie, Bongomin, Felix, Bonomo, Robert A, Bradley, John S, Bradshaw, Catriona, Brett, Ana, Brink, Adrian, Brown, Colin, Brown, Jeremy, Buising, Kirsty, Carson, Carolee, Carvalho, Anna Cristina, Castagnola, Elio, Cavaleri, Marco, Cecchini, Michele, Chabala, Chishala, Chaisson, Richard E, Chakrabarti, Arunaloke, Chandler, Clare, Chandy, Sujith John, Charani, Esmita, Chen, Lisa, Chiara, Francesca, Chowdhary, Anuradha, Chua, Arlene, Chuki, Pem, Chun, Doo Ryeon, Churchyard, Gavin, Cirillo, Daniela, Clack, Lauren, Coffin, Susan E, Cohn, Jennifer, Cole, Michelle, Conly, John, Cooper, Ben, Corso, Alejandra, Cosgrove, Sara E, Cox, Helen, Daley, Charles L, Darboe, Saffiatou, Darton, Tom, Davies, Gerry, de Egea, Viviana, Dedeić-Ljubović, Amela, Deeves, Miranda, Denkinger, Claudia, Dillon, Jo-Anne R, Dramowski, Angela, Eley, Brian, Roberta Esposito, Susanna Maria, Essack, Sabiha Y, Farida, Helmia, Farooqi, Joveria, Feasey, Nicholas, Ferreyra, Cecilia, Fifer, Helen, Finlayson, Heather, Frick, Mike, Gales, Ana Cristina, Galli, Luisa, Gandra, Sumanth, Gerber, Jeffrey S, Giske, Christian, Gordon, Bruce, Govender, Nelesh, Guessennd, Nathalie, Guindo, Ibrehima, Gurbanova, Elmira, Gwee, Amanda, Hagen, Ferry, Harbarth, Stephan, Haze, John, Heim, Jutta, Hendriksen, Rene, Heyderman, Robert Simon, Holt, Kathryn Elizabeth, Hönigl, Martin, Hook, Edward W, Hope, William, Hopkins, Heidi, Hughes, Gwenda, Ismail, Ghada, Issack, Mohammad Iqbal, Jacobs, Jan, Jasovský, Dušan, Jehan, Fyeza, Pearson, Antonieta Jimenez, Jones, Makoto, Joshi, Mohan P, Kapil, Arti, Kariuki, Samuel, Karkey, Abhilasha, Kearns, Gregory L, Keddy, Karen Helena, Khanna, Nina, Kitamura, Akiko, Kolho, Kaija-Leena, Kontoyiannis, Dimitrios P, Kotwani, Anita, Kozlov, Roman S, Kranzer, Katharina, Kularatne, Ranmini, Lahra, Monica M, Langford, Bradley J, Laniado-Laborin, Rafael, Larsson, Joakim, Lass-Flörl, Cornelia, Le Doare, Kirsty, Lee, Hyukmin, Lessa, Fernanda, Levin, Anna S, Limmathurotsakul, Direk, Lincopan, Nilton, Lo Vecchio, Andrea, Lodha, Rakesh, Loeb, Mark, Longtin, Yves, Lye, David Chien, Mahmud, Asif Mujtaba, Manaia, Célia, Manderson, Lenore, Mareković, Ivana, Marimuthu, Kalisvar, Martin, Irene, Mashe, Tapfumanei, Mei, Zeng, Meis, Jacques F, Lyra Tavares De Melo, Flávio Augusto, Mendelson, Marc, Miranda, Angelica Espinosa, Moore, David, Morel, Chantal, Moremi, Nyambura, Moro, Maria Luisa, Moussy, Francis, Mshana, Stephen, Mueller, Arno, Ndow, Francis J, Nicol, Mark, Nunn, Andrew, Obaro, Stephen, Obiero, Christina W, Okeke, Iruka N, Okomo, Uduak, Okwor, Tochi J, Oladele, Rita, Omulo, Sylvia, Ondoa, Pascale, Ortellado de Canese, Juana Medarda, Ostrosky-Zeichner, Luis, Padoveze, Maria Clara, Pai, Madhukar, Park, Benjamin, Parkhill, Julian, Parry, Christopher M, Peeling, Rosanna, Sobreira Vieira Peixe, Luísa Maria, Perovic, Olga, Pettigrew, Melinda M, Principi, Nicola, Pulcini, Céline, Puspandari, Nelly, Rawson, Timothy, Reddy, Denasha Lavanya, Reddy, Kessendri, Redner, Paulo, Rodríguez Tudela, Juan Luis, Rodríguez-Baño, Jesús, Van Katwyk, Susan Rogers, Roilides, Emmanuel, Rollier, Christine, Rollock, Leslie, Ronat, Jean-Baptiste, Ruppe, Etienne, Sadarangani, Manish, Salisbury, David, Salou, Mounerou, Samison, Luc Hervé, Sanguinetti, Maurizio, Sartelli, Massimo, Schellack, Natalie, Schouten, Jeroen, Schwaber, Mitchell J, Seni, Jeremiah, Senok, Abiola, Shafer, William M, Shakoor, Sadia, Sheppard, Donald, Shin, Jong-Hee, Sia, Sonia, Sievert, Dawn, Singh, Ishwar, Singla, Rupak, Skov, Robert Leo, Soge, Olusegun O, Sprute, Rosanne, Srinivasan, Arjun, Srinivasan, Subasree, Sundsfjord, Arnfinn, Tacconelli, Evelina, Tahseen, Sabira, Tangcharoensathien, Viroj, Tängdén, Thomas, Thursky, Karin, Thwaites, Guy, Tigulini de Souza Peral, Renata, Tong, Deborah, Tootla, Hafsah Deepa, Tsioutis, Constantinos, Turner, Katy M, Turner, Paul, Omar, Shaheed Vally, van de Sande, Wendy WJ, van den Hof, Susan, van Doorn, Rogier, Veeraraghavan, Balaji, Verweij, Paul, Wahyuningsih, Retno, Wang, Hui, Warris, Adilia, Weinstock, Hillard, Wesangula, Evelyn, Whiley, David, White, Peter J, Williams, Phoebe, Xiao, Yonghong, Moscoso, Martin Yagui, Yang, Hsu Li, Yoshida, Sachiyo, Yu, Yunsong, Żabicka, Dorota, Zignol, Matteo, Bertagnolio, Silvia, Dobreva, Zlatina, Centner, Chad M, Olaru, Ioana Diana, Donà, Daniele, Burzo, Stefano, Huttner, Benedikt D, Chaillon, Antoine, Gebreselassie, Nebiat, Wi, Teodora, Hasso-Agopsowicz, Mateusz, Allegranzi, Benedetta, Sati, Hatim, Ivanovska, Verica, Kothari, Kavita U, Balkhy, Hanan H, Cassini, Alessandro, Hamers, Raph L, Weezenbeek, Kitty Van, Aanensen, David, Alanio, Alexandre, Alastruey-Izquierdo, Ana, Alemayehu, Tinsae, Al-Hasan, Majdi, Allegaert, Karel, Al-Maani, Amal Saif, Al-Salman, Jameela, Alshukairi, Abeer Nizar, Amir, Afreenish, Applegate, Tanya, Araj, George F, Villalobos, Marlen Arce, Årdal, Christine, Ashiru-Oredope, Diane, Ashley, Elizabeth A, Babin, François-Xavier, Bachmann, Laura H, Bachmann, Till, Baker, Kate Susan, Balasegaram, Manica, Bamford, Colleen, Baquero, Fernando, Barcelona, Laura Isabel, Bassat, Quique, Bassetti, Matteo, Basu, Sulagna, Beardsley, Justin, Vásquez, Grey Benoit, Berkley, James A, Bhatnagar, Anuj K, Bielicki, Julia, Bines, Julie, Bongomin, Felix, Bonomo, Robert A, Bradley, John S, Bradshaw, Catriona, Brett, Ana, Brink, Adrian, Brown, Colin, Brown, Jeremy, Buising, Kirsty, Carson, Carolee, Carvalho, Anna Cristina, Castagnola, Elio, Cavaleri, Marco, Cecchini, Michele, Chabala, Chishala, Chaisson, Richard E, Chakrabarti, Arunaloke, Chandler, Clare, Chandy, Sujith John, Charani, Esmita, Chen, Lisa, Chiara, Francesca, Chowdhary, Anuradha, Chua, Arlene, Chuki, Pem, Chun, Doo Ryeon, Churchyard, Gavin, Cirillo, Daniela, Clack, Lauren, Coffin, Susan E, Cohn, Jennifer, Cole, Michelle, Conly, John, Cooper, Ben, Corso, Alejandra, Cosgrove, Sara E, Cox, Helen, Daley, Charles L, Darboe, Saffiatou, Darton, Tom, Davies, Gerry, de Egea, Viviana, Dedeić-Ljubović, Amela, Deeves, Miranda, Denkinger, Claudia, Dillon, Jo-Anne R, Dramowski, Angela, Eley, Brian, Roberta Esposito, Susanna Maria, Essack, Sabiha Y, Farida, Helmia, Farooqi, Joveria, Feasey, Nicholas, Ferreyra, Cecilia, Fifer, Helen, Finlayson, Heather, Frick, Mike, Gales, Ana Cristina, Galli, Luisa, Gandra, Sumanth, Gerber, Jeffrey S, Giske, Christian, Gordon, Bruce, Govender, Nelesh, Guessennd, Nathalie, Guindo, Ibrehima, Gurbanova, Elmira, Gwee, Amanda, Hagen, Ferry, Harbarth, Stephan, Haze, John, Heim, Jutta, Hendriksen, Rene, Heyderman, Robert Simon, Holt, Kathryn Elizabeth, Hönigl, Martin, Hook, Edward W, Hope, William, Hopkins, Heidi, Hughes, Gwenda, Ismail, Ghada, Issack, Mohammad Iqbal, Jacobs, Jan, Jasovský, Dušan, Jehan, Fyeza, Pearson, Antonieta Jimenez, Jones, Makoto, Joshi, Mohan P, Kapil, Arti, Kariuki, Samuel, Karkey, Abhilasha, Kearns, Gregory L, Keddy, Karen Helena, Khanna, Nina, Kitamura, Akiko, Kolho, Kaija-Leena, Kontoyiannis, Dimitrios P, Kotwani, Anita, Kozlov, Roman S, Kranzer, Katharina, Kularatne, Ranmini, Lahra, Monica M, Langford, Bradley J, Laniado-Laborin, Rafael, Larsson, Joakim, Lass-Flörl, Cornelia, Le Doare, Kirsty, Lee, Hyukmin, Lessa, Fernanda, Levin, Anna S, Limmathurotsakul, Direk, Lincopan, Nilton, Lo Vecchio, Andrea, Lodha, Rakesh, Loeb, Mark, Longtin, Yves, Lye, David Chien, Mahmud, Asif Mujtaba, Manaia, Célia, Manderson, Lenore, Mareković, Ivana, Marimuthu, Kalisvar, Martin, Irene, Mashe, Tapfumanei, Mei, Zeng, Meis, Jacques F, Lyra Tavares De Melo, Flávio Augusto, Mendelson, Marc, Miranda, Angelica Espinosa, Moore, David, Morel, Chantal, Moremi, Nyambura, Moro, Maria Luisa, Moussy, Francis, Mshana, Stephen, Mueller, Arno, Ndow, Francis J, Nicol, Mark, Nunn, Andrew, Obaro, Stephen, Obiero, Christina W, Okeke, Iruka N, Okomo, Uduak, Okwor, Tochi J, Oladele, Rita, Omulo, Sylvia, Ondoa, Pascale, Ortellado de Canese, Juana Medarda, Ostrosky-Zeichner, Luis, Padoveze, Maria Clara, Pai, Madhukar, Park, Benjamin, Parkhill, Julian, Parry, Christopher M, Peeling, Rosanna, Sobreira Vieira Peixe, Luísa Maria, Perovic, Olga, Pettigrew, Melinda M, Principi, Nicola, Pulcini, Céline, Puspandari, Nelly, Rawson, Timothy, Reddy, Denasha Lavanya, Reddy, Kessendri, Redner, Paulo, Rodríguez Tudela, Juan Luis, Rodríguez-Baño, Jesús, Van Katwyk, Susan Rogers, Roilides, Emmanuel, Rollier, Christine, Rollock, Leslie, Ronat, Jean-Baptiste, Ruppe, Etienne, Sadarangani, Manish, Salisbury, David, Salou, Mounerou, Samison, Luc Hervé, Sanguinetti, Maurizio, Sartelli, Massimo, Schellack, Natalie, Schouten, Jeroen, Schwaber, Mitchell J, Seni, Jeremiah, Senok, Abiola, Shafer, William M, Shakoor, Sadia, Sheppard, Donald, Shin, Jong-Hee, Sia, Sonia, Sievert, Dawn, Singh, Ishwar, Singla, Rupak, Skov, Robert Leo, Soge, Olusegun O, Sprute, Rosanne, Srinivasan, Arjun, Srinivasan, Subasree, Sundsfjord, Arnfinn, Tacconelli, Evelina, Tahseen, Sabira, Tangcharoensathien, Viroj, Tängdén, Thomas, Thursky, Karin, Thwaites, Guy, Tigulini de Souza Peral, Renata, Tong, Deborah, Tootla, Hafsah Deepa, Tsioutis, Constantinos, Turner, Katy M, Turner, Paul, Omar, Shaheed Vally, van de Sande, Wendy WJ, van den Hof, Susan, van Doorn, Rogier, Veeraraghavan, Balaji, Verweij, Paul, Wahyuningsih, Retno, Wang, Hui, Warris, Adilia, Weinstock, Hillard, Wesangula, Evelyn, Whiley, David, White, Peter J, Williams, Phoebe, Xiao, Yonghong, Moscoso, Martin Yagui, Yang, Hsu Li, Yoshida, Sachiyo, Yu, Yunsong, Żabicka, Dorota, and Zignol, Matteo
- Abstract
The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.
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- 2024
33. Candida albicans—A systematic review to inform the World Health Organization Fungal Priority Pathogens List.
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Parambath, Sarika, Dao, Aiken, Kim, Hannah Yejin, Zawahir, Shukry, Izquierdo, Ana-Alastruey, Tacconelli, Evelina, Govender, Nelesh, Oladele, Rita, Colombo, Arnaldo, Sorrell, Tania, Ramon-Pardo, Pilar, Fusire, Terence, Gigante, Valeria, Sati, Hatim, Morrissey, C Orla, Alffenaar, Jan-Willem, and Beardsley, Justin
- Abstract
Candida albicans is a common fungal pathogen and amongst the leading causes of invasive candidiasis globally. This systematic review examines the characteristics and global impact of invasive infections caused by C. albicans. We searched on PubMed and Web of Science for studies reporting on criteria such as mortality, morbidity, drug resistance, preventability, yearly incidence, and distribution/emergence during the period from 2016 to 2021. Our findings indicate that C. albicans is the most common Candida species causing invasive disease and that standard infection control measures are the primary means of prevention. However, we found high rates of mortality associated with infections caused by C. albicans. Furthermore, there is a lack of data on complications and sequelae. Resistance to commonly used antifungals remains rare. Although, whilst generally susceptible to azoles, we found some evidence of increasing resistance, particularly in middle-income settings—notably, data from low-income settings were limited. Candida albicans remains susceptible to echinocandins, amphotericin B, and flucytosine. We observed evidence of a decreasing proportion of infections caused by C. albicans relative to other Candida species, although detailed epidemiological studies are needed to confirm this trend. More robust data on attributable mortality, complications, and sequelae are needed to understand the full extent of the impact of invasive C. albicans infections. [ABSTRACT FROM AUTHOR]
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- 2024
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34. Features and global impact of invasive fungal infections caused by Pneumocystis jirovecii: A systematic review to inform the World Health Organization fungal priority pathogens list.
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McMullan, Brendan, Kim, Hannah Yejin, Alastruey-Izquierdo, Ana, Tacconelli, Evelina, Dao, Aiken, Oladele, Rita, Tanti, Daniel, Govender, Nelesh P, Shin, Jong-Hee, Heim, Jutta, Ford, Nathan Paul, Huttner, Benedikt, Galas, Marcelo, Nahrgang, Saskia Andrea, Gigante, Valeria, Sati, Hatim, Alffenaar, Jan Willem, Morrissey, C Orla, and Beardsley, Justin
- Abstract
This systematic review evaluates the current global impact of invasive infections caused by Pneumocystis jirovecii (principally pneumonia: PJP), and was carried out to inform the World Health Organization Fungal Priority Pathogens List. PubMed and Web of Science were used to find studies reporting mortality, inpatient care, complications/sequelae, antifungal susceptibility/resistance, preventability, annual incidence, global distribution, and emergence in the past 10 years, published from January 2011 to February 2021. Reported mortality is highly variable, depending on the patient population: In studies of persons with HIV, mortality was reported at 5%–30%, while in studies of persons without HIV, mortality ranged from 4% to 76%. Risk factors for disease principally include immunosuppression from HIV, but other types of immunosuppression are increasingly recognised, including solid organ and haematopoietic stem cell transplantation, autoimmune and inflammatory disease, and chemotherapy for cancer. Although prophylaxis is available and generally effective, burdensome side effects may lead to discontinuation. After a period of decline associated with improvement in access to HIV treatment, new risk groups of immunosuppressed patients with PJP are increasingly identified, including solid organ transplant patients. [ABSTRACT FROM AUTHOR]
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- 2024
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35. Candida parapsilosis: A systematic review to inform the World Health Organization fungal priority pathogens list.
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Asogan, Mrudhula, Kim, Hannah Yejin, Kidd, Sarah, Alastruey-Izquierdo, Ana, Govender, Nelesh P, Dao, Aiken, Shin, Jong-Hee, Heim, Jutta, Ford, Nathan Paul, Gigante, Valeria, Sati, Hatim, Morrissey, C Orla, Alffenaar, Jan-Willem, and Beardsley, Justin
- Abstract
Candida parapsilosis is globally distributed and recognised for causing an increasing proportion of invasive Candida infections. It is associated with high crude mortality in all age groups. It has been particularly associated with nosocomial outbreaks, particularly in association with the use of invasive medical devices such as central venous catheters. Candida parapsilosis is one of the pathogens considered in the WHO priority pathogens list, and this review was conducted to inform the ranking of the pathogen in the list. In this systematic review, we searched PubMed and Web of Science to find studies between 2011 and 2021 reporting on the following criteria for C. parapsilosis infections: mortality, morbidity (hospitalisation and disability), drug resistance, preventability, yearly incidence, and distribution/emergence. We identified 336 potentially relevant papers, of which 51 were included in the analyses. The included studies confirmed high mortality rates, ranging from 17.5% to 46.8%. Data on disability and sequelae were sparse. Many reports highlighted concerns with azole resistance, with resistance rates of >10% described in some regions. Annual incidence rates were relatively poorly described, although there was clear evidence that the proportion of candidaemia cases caused by C. parapsilosis increased over time. While this review summarises current data on C.parapsilosis , there remains an urgent need for ongoing research and surveillance to fully understand and manage this increasingly important pathogen. [ABSTRACT FROM AUTHOR]
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- 2024
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36. Optimizing the Treatment of Invasive Candidiasis—A Case for Combination Therapy.
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Wake, Rachel M, Allebone-Salt, Phoebe E, John, Larissa L H, Caswall, Ben A, Govender, Nelesh P, Ben-Ami, Ronen, Murray, Lyle W, Logan, Clare, Harrison, Thomas S, and Bicanic, Tihana A
- Subjects
ANTIMICROBIAL stewardship ,INVASIVE candidiasis ,DRUG resistance ,INFECTION control ,WORLD health ,CANDIDA - Abstract
Invasive candidiasis is a rising global health threat with increasing incidence, persistently high mortality, and diminishing treatment options. Antifungal resistance has rapidly emerged and spread, with multidrug-resistant species deemed an urgent and serious threat. While acknowledging the key role of antifungal stewardship and infection control in curbing spread, we examine the role of antifungal monotherapy in driving resistance and the potential for combination therapy to prevent stress adaptation and emergence of drug resistance. In addition to its role in mitigating resistance, combination treatment may improve drug penetration, expedite fungal clearance, and allow lower, less toxic doses of individual drugs to be used. A growing body of laboratory-based evidence suggests that antifungal combinations can yield synergistic activity against Candida spp. including against frequently multidrug-resistant Candida auris. It is imperative to test these combinations in clinical trials, incorporating resistance end points as a marker of success. [ABSTRACT FROM AUTHOR]
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- 2024
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37. Initial findings from a novel population-based child mortality surveillance approach: a descriptive study
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Acácio, Sozinho, Adam, Yasmin, Ajanovic, Sara, Alam, Muntasir, Alkis Ramirez, Rebecca, Badji, Henry, Bari, Sanwarul, Caneer, J. Patrick, Chowdhury, Atique Iqbal, Diaz, Maureen H., Fairchild, Karen D., Flora, Meerjady Sabrina, Garel, Mischka, Gibby, Adriana, Govender, Nelesh P., Greene, Carol L., Hale, Martin John, Hurtado, Juan Carlos, Johnson, J. Kristie, Kamal, Mohammed, Keita, Tatiana, Koka, Rima, Koné, Diakaridia, Lala, Sanjay G., Lombaard, Hennie, Mabunda, Rita, Martines, Roosecelis B., Mehta, Ashka, Menéndez, Clara, Mocumbi, Sibone, Moya, Claudia, Nhampossa, Tacilta, Onwuchekwa, Uma U., Parveen, Shahana, Petersen, Karen L., Phillipsborn, Rebecca Pass, Rahman, Mustafizur, Rakislova, Natalia, Ritter, Jana, Sazzad, Hossain M.S., Sidibe, Diakaridia, Sitoe, Antonio, Sivalogan, Kasthuri, Swanson, Jennifer M., Swart, Peter J., Tennant, Sharon M., Traoré, Cheick B., Varo Cobos, Rosauro, Vitorino, Pio, Valente, Marta, Velaphi, Sithembiso, Wadula, Jeannette, Waller, Jessica L., Wilkinson, Amanda L., Winchell, Jonas M., Taylor, Allan W, Blau, Dianna M, Bassat, Quique, Onyango, Dickens, Kotloff, Karen L, Arifeen, Shams El, Mandomando, Inacio, Chawana, Richard, Baillie, Vicky L, Akelo, Victor, Tapia, Milagritos D, Salzberg, Navit T, Keita, Adama Mamby, Morris, Timothy, Nair, Shailesh, Assefa, Nega, Seale, Anna C, Scott, J Anthony G, Kaiser, Reinhard, Jambai, Amara, Barr, Beth A Tippet, Gurley, Emily S, Ordi, Jaume, Zaki, Sherif R, Sow, Samba O, Islam, Farzana, Rahman, Afruna, Dowell, Scott F, Koplan, Jeffrey P, Raghunathan, Pratima L, Madhi, Shabir A, and Breiman, Robert F
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- 2020
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38. AIDS-Related Mycoses: Updated Progress and Future Priorities
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Hoving, J. Claire, Brown, Gordon D., Gómez, Beatriz L., Govender, Nelesh P., Limper, Andrew H., May, Robin C., and Meya, David B.
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- 2020
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39. Time to embrace access programmes for medicines: lessons from the South African flucytosine access programme
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Shroufi, Amir, Govender, Nelesh P., Meintjes, Graeme, Black, John, Nel, Jeremy, Moosa, Mahomed-Yunus S., Menezes, Colin, Dawood, Halima, Wilson, Douglas, Duran, Laura Trivino, Ajose, Olawale, Murphy, Richard A., Harrison, Thomas, Loyse, Angela, Ruffell, Carol, and Van Cutsem, Gilles
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- 2020
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40. A trial to understand how a new formulation of flucytosine works in the body among people with early cryptococcal disease
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Govender, Nelesh, primary, Molloy, Sile, additional, Comins, Kyla, additional, and Adams, Jack, additional
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- 2024
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41. The pathogenesis of experimental Emergomycosis in mice
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Höft, Maxine A., primary, Duvenage, Lucian, additional, Salie, Sumayah, additional, Keeton, Roanne, additional, Botha, Alfred, additional, Schwartz, Ilan S., additional, Govender, Nelesh P., additional, Brown, Gordon D., additional, and Hoving, Jennifer Claire, additional
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- 2024
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42. In vitro manogepix susceptibility testing of South African Emergomyces africanus, Emergomyces pasteurianus , and Blastomyces emzantsi clinical isolates
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Nzimande, Silondiwe P., primary, Govender, Nelesh P., additional, and Maphanga, Tsidiso G., additional
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- 2023
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43. Rapid urine-based screening tests increase the yield of same-day tuberculosis diagnoses among patients living with advanced HIV disease
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Wake, Rachel M., Govender, Nelesh P., Omar, Shaheed V., Ismail, Farzana, Tiemessen, Caroline T., Harrison, Thomas S., and Jarvis, Joseph N.
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- 2022
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44. Leave no one behind: response to new evidence and guidelines for the management of cryptococcal meningitis in low-income and middle-income countries
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Loyse, Angela, Burry, Jessica, Cohn, Jennifer, Ford, Nathan, Chiller, Tom, Ribeiro, Isabela, Koulla-Shiro, Sinata, Mghamba, Janneth, Ramadhani, Angela, Nyirenda, Rose, Aliyu, Sani H, Wilson, Douglas, Le, Thuy, Oladele, Rita, Lesikari, Sokoine, Muzoora, Conrad, Kalata, Newton, Temfack, Elvis, Mapoure, Yacouba, Sini, Victor, Chanda, Duncan, Shimwela, Meshack, Lakhi, Shabir, Ngoma, Jonathon, Gondwe-Chunda, Lilian, Perfect, Chase, Shroufi, Amir, Andrieux-Meyer, Isabelle, Chan, Adrienne, Schutz, Charlotte, Hosseinipour, Mina, Van der Horst, Charles, Klausner, Jeffrey D, Boulware, David R, Heyderman, Robert, Lalloo, David, Day, Jeremy, Jarvis, Joseph N, Rodrigues, Marcio, Jaffar, Shabbar, Denning, David, Migone, Chantal, Doherty, Megan, Lortholary, Olivier, Dromer, Françoise, Stack, Muirgen, Molloy, Síle F, Bicanic, Tihana, van Oosterhout, Joep, Mwaba, Peter, Kanyama, Cecilia, Kouanfack, Charles, Mfinanga, Sayoki, Govender, Nelesh, and Harrison, Thomas S
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- 2019
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45. Provider adherence to clinical care recommendations for infants and children who died in seven low- and middle-income countries in the Child Health and Mortality Prevention Surveillance (CHAMPS) network
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Rees, Chris A., primary, Igunza, Kitiezo Aggrey, additional, Madewell, Zachary J., additional, Akelo, Victor, additional, Onyango, Dickens, additional, El Arifeen, Shams, additional, Gurley, Emily S., additional, Hossain, Mohammad Zahid, additional, Rahman, Afruna, additional, Alam, Muntasir, additional, Scott, J. Anthony G., additional, Assefa, Nega, additional, Madrid, Lola, additional, Belachew, Anteneh, additional, Leulseged, Haleluya, additional, Kotloff, Karen L., additional, Sow, Samba O., additional, Tapia, Milagritos D., additional, Keita, Adama Mamby, additional, Sidibe, Diakaridia, additional, Sitoe, Antonio, additional, Varo, Rosauro, additional, Ajanovic, Sara, additional, Bassat, Quique, additional, Mandomando, Inácio, additional, Tippett Barr, Beth A., additional, Ogbuanu, Ikechukwu, additional, Cain, Carrie Jo, additional, Bassey, Ima-Abasi, additional, Luke, Ronita, additional, Gassama, Khadija, additional, Madhi, Shabir, additional, Dangor, Ziyaad, additional, Mahtab, Sana, additional, Velaphi, Sithembiso, additional, du Toit, Jeanie, additional, Mutevedzi, Portia C., additional, Blau, Dianna M., additional, Breiman, Robert F., additional, Whitney, Cynthia G., additional, Solomon, Fatima, additional, Sorour, Gillian, additional, Lombaard, Hennie, additional, Wadula, Jeannette, additional, Petersen, Karen, additional, Hale, Martin, additional, Govender, Nelesh P., additional, Swart, Peter J., additional, Lala, Sanjay G., additional, Chawana, Richard, additional, Adam, Yasmin, additional, Wise, Amy, additional, Fritz, Ashleigh, additional, Myburgh, Nellie, additional, Ndagurwa, Pedzisai, additional, Hwinya, Cleopas, additional, Bari, Sanwarul, additional, Parveen, Shahana, additional, Kamal, Mohammed, additional, Uddin Ahmed, A.S.M. Nawshad, additional, Hoque, Mahbubul, additional, Tasnim, Saria, additional, Islam, Ferdousi, additional, Ariuman, Farida, additional, Rahman, Mohammad Mosiur, additional, Begum, Ferdousi, additional, Zaman, K., additional, Rahman, Mustafizur, additional, Ahmed, Dilruba, additional, Flora, Meerjady Sabrina, additional, Shirin, Tahmina, additional, Rahman, Mahbubur, additional, Oundo, Joseph, additional, Ibrahim, Alexander M., additional, Temesgen, Fikremelekot, additional, Gure, Tadesse, additional, Alemu, Addisu, additional, Yeshi, Melisachew Mulatu, additional, Gizaw, Mahlet Abayneh, additional, Orlien, Stian, additional, Ali, Solomon, additional, Otieno, Peter, additional, Onyango, Peter Nyamthimba, additional, Agaya, Janet, additional, Oliech, Richard, additional, Were, Joyce Akinyi, additional, Gethi, Dickson, additional, Khagayi, Sammy, additional, Aol, George, additional, Misore, Thomas, additional, Owuor, Harun, additional, Mugah, Christopher, additional, Oluoch, Bernard, additional, Ochola, Christine, additional, Tennant, Sharon M., additional, Greene, Carol L., additional, Mehta, Ashka, additional, Johnson, J. Kristie, additional, Gaume, Brigitte, additional, Koka, Rima, additional, Fairchild, Karen D., additional, Kone, Diakaridia, additional, Sanogo, Doh, additional, Onwuchekwa, Uma U., additional, Kourouma, Nana, additional, Sissoko, Seydou, additional, Traore, Cheick Bougadari, additional, Juma, Jane, additional, Diarra, Kounandji, additional, Traore, Awa, additional, Diarra, Tiéman, additional, Chawla, Kiranpreet, additional, Nhampossa, Tacilta, additional, Manhique, Zara, additional, Mocumbi, Sibone, additional, Menéndez, Clara, additional, Munguambe, Khátia, additional, Nhacolo, Ariel, additional, Maixenchs, Maria, additional, Moseray, Andrew, additional, Tarawally, Fatmata Bintu, additional, Seppeh, Martin, additional, Mash, Ronald, additional, Ojulong, Julius, additional, Duduyemi, Babatunde, additional, Bunn, James, additional, Swaray-Deen, Alim, additional, Bangura, Joseph, additional, Jambai, Amara, additional, Mannah, Margaret, additional, Ita, Okokon, additional, Chukwuegbo, Cornell, additional, Sannoh, Sulaiman, additional, Nwajiobi, Princewill, additional, Kowuor, Dickens, additional, Kaluma, Erick, additional, Balogun, Oluseyi, additional, Samura, Solomon, additional, Pratt, Samuel, additional, Moses, Francis, additional, Sesay, Tom, additional, Squire, James, additional, Sesay, Joseph Kamanda, additional, Kaykay, Osman, additional, Halu, Binyam, additional, Legesse, Hailemariam, additional, Smart, Francis, additional, Kenneh, Sartie, additional, Ameh, Soter, additional, Ritter, Jana, additional, Wilson, Tais, additional, Winchell, Jonas, additional, Witherbee, Jakob, additional, Salzberg, Navit T., additional, Koplan, Jeffrey P., additional, Basket, Margaret, additional, Wadhwa, Ashutosh, additional, Lee, Kyu Han, additional, Wanga, Valentine, additional, Martines, Roosecelis, additional, Warang, Shamta, additional, Diaz, Maureen, additional, Waller, Jessica, additional, Nair, Shailesh, additional, Liu, Lucy, additional, Bursuc, Courtney, additional, LaHatte, Kristin, additional, Raymer, Sarah, additional, Blevins, John, additional, Argeseanu, Solveig, additional, Vyas, Kurt, additional, and Bhandari, Manu, additional
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- 2023
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46. The Continuing Burden of Advanced HIV Disease Over 10 Years of Increasing Antiretroviral Therapy Coverage in South Africa
- Author
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Osler, Meg, Hilderbrand, Katherine, Goemaere, Eric, Ford, Nathan, Smith, Mariette, Meintjes, Graeme, Kruger, James, Govender, Nelesh P., and Boulle, Andrew
- Published
- 2018
47. High Cryptococcal Antigen Titers in Blood Are Predictive of Subclinical Cryptococcal Meningitis Among Human Immunodeficiency Virus-Infected Patients
- Author
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Wake, Rachel M., Britz, Erika, Sriruttan, Charlotte, Rukasha, Ivy, Omar, Tanvier, Spencer, David C., Nel, Jeremy S., Mashamaite, Sello, Adelekan, Adeboye, Chiller, Tom M., Jarvis, Joseph N., Harrison, Thomas S., and Govender, Nelesh P.
- Published
- 2018
48. Children and fungal priority pathogens
- Author
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McMullan, Brendan, Govender, Nelesh, Carlesse, Fabianne, Singhal, Tanu, Sati, Hatim, and Warris, Adilia
- Published
- 2024
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49. Epidemiologic Shift in Candidemia Driven by Candida auris, South Africa, 2016-2017
- Author
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van Schalkwyk, Erika, Mpembe, Ruth S., Thomas, Juno, Shuping, Liliwe, Ismail, Husna, Lowman, Warren, Karstaedt, Alan S., Chibabhai, Vindana, Wadula, Jeannette, Avenant, Theunis, Messina, Angeliki, Govind, Chetna N., Moodley, Krishnee, Dawood, Halima, Ramjathan, Praksha, and Govender, Nelesh P.
- Subjects
Mycoses -- Health aspects -- Comparative analysis ,Antifungal agents -- Health aspects -- Comparative analysis ,Mass spectrometry -- Health aspects -- Comparative analysis ,Infection -- Health aspects -- Comparative analysis ,Intelligence gathering ,Spectroscopy ,Health - Abstract
Since 2009, when the first case of Candida auris infection was identified in South Africa, the number of laboratory-confirmed cases has increased exponentially (1). This multidrug-resistant fungal pathogen emerged worldwide, [...]
- Published
- 2019
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50. Impact of prior cryptococcal antigen screening on in-hospital mortality in cryptococcal meningitis or fungemia among HIV-seropositive individuals in South Africa: a cross-sectional observational study
- Author
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Paccoud, Olivier, primary, Shuping, Liliwe, additional, Mashau, Rudzani, additional, Greene, Greg, additional, Quan, Vanessa, additional, Meiring, Susan, additional, Govender, Nelesh P., additional, Abrahams, Shareef, additional, Ahmed, Khatija, additional, Avenant, Theunis, additional, Bamford, Colleen, additional, Bhola, Prathna, additional, Bishop, Kate, additional, Black, John, additional, Blumberg, Lucille, additional, Bosman, Norma, additional, Botha, Maria, additional, Brink, Adrian, additional, Budavari, Suzy, additional, Burra, Asmeeta, additional, Chibabhai, Vindana, additional, Chomba, Rispah, additional, Cohen, Cheryl, additional, Coovadia, Yacoob, additional, Crowther-Gibson, Penny, additional, Dawood, Halima, additional, de Gouveia, Linda, additional, Dlamini, Nomonde, additional, Dlamini, Siyanda, additional, Dreyer, Andries, additional, du Plessis, Nicolette, additional, du Plessis, Erna, additional, du Plessis, Mignon, additional, Erasmus, Linda, additional, Feldman, Charles, additional, Govender, Nelesh, additional, Govind, Chetna, additional, Groome, Michelle, additional, Haffejee, Sumayya, additional, Hamese, Ken, additional, Haumann, Carel, additional, Hoho, Nombulelo, additional, Hoosen, Anwar, additional, Hoosien, Ebrahim, additional, Howell, Victoria, additional, Hoyland, Greta, additional, Ismail, Farzana, additional, Ismail, Husna, additional, Ismail, Nazir, additional, Ive, Prudence, additional, Jooste, Pieter, additional, Karstaedt, Alan, additional, Khantsi, Ignatius, additional, Kleinhans, Vicky, additional, Kleynhans, Jackie, additional, Kolojane, Molebogeng, additional, Kufa-Chakezha, Tendesayi, additional, Lebaka, Tiisetso, additional, Lebudi, Jacob, additional, Legare, Neo, additional, Lekalakala, Ruth, additional, Lindeque, Kathy, additional, Lowman, Warren, additional, Madhi, Shabir, additional, Magobo, Rindidzani, additional, Mahabeer, Prasha, additional, Maharaj, Adhil, additional, Makgoba, Martha, additional, Maloba, Molatji, additional, Maluleka, Caroline, additional, Manaka, Mokupi, additional, Mangena, Phetho, additional, Maningi, Nontuthuko, additional, Marcus, Louis, additional, Marshall, Terry, additional, Mathebula, Rudzani, additional, Mathunjwa, Azwifarwi, additional, Mbelle, Nontombi, additional, Mbuthu, Bongani, additional, McCarthy, Kerrigan, additional, Mekgoe, Omphile, additional, Menezes, Colin, additional, Miller, Cecilia, additional, Mlisana, Koleka, additional, Moncho, Masego, additional, Moore, David, additional, Moremi, Myra, additional, Morris, Lynn, additional, Moshe, Moamokgethi, additional, Mothibi, Lesego, additional, Moultrie, Harry, additional, Mpembe, Ruth, additional, Mutevedzi, Portia, additional, Mwansa-Kambafwile, Judith, additional, Naby, Fathima, additional, Naicker, Preneshni, additional, Naidoo, Romola, additional, Nana, Trusha, additional, Nchabeleng, Maphoshane, additional, Ndlovu, Phathutshedzo, additional, Nel, Jeremy, additional, Ngomane, Mimmy, additional, Ngubane, Wendy, additional, Nicol, Mark, additional, Njikho, Sunnieboy, additional, Ntlemo, Grace, additional, Ntuli, Sindi, additional, Page, Nicola, additional, Paulse, Nuraan, additional, Pearce, Vanessa, additional, Perovic, Olga, additional, Pillay, Keshree, additional, Pombo, Dina, additional, Poswa, Xoliswa, additional, Prentice, Elizabeth, additional, Puren, Adrian, additional, Ramjathan, Praksha, additional, Ramkillawan, Yeishna, additional, Reddy, Kessendri, additional, Reubenson, Gary, additional, Richards, Lauren, additional, Said, Mohammed, additional, Samodien, Nazlee, additional, Samuel, Catherine, additional, Seetharam, Sharona, additional, Sekwadi, Phuti, additional, Selekisho, Mirriam, additional, Senekal, Marthinus, additional, Sibiya, Ngoaka, additional, Sirkar, Surendra, additional, Smit, Juanita, additional, Smith, Anthony, additional, Smith, Marshagne, additional, Sookan, Lisha, additional, Sriruttan, Charlotte, additional, Stacey, Sarah, additional, Swe Han, Khine Swe, additional, Thomas, Teena, additional, Thomas, Juno, additional, Tsisti, Merika, additional, van Schalkwyk, Erika, additional, Variava, Ebrahim, additional, Vazi, Phumeza, additional, Verwey, Charl, additional, von Gottberg, Anne, additional, Wadula, Jeanntte, additional, Walaza, Sibongile, additional, Wende, Linda, additional, Whitelaw, Andrew, additional, Wilson, Douglas, additional, and Zietsman, Inge, additional
- Published
- 2023
- Full Text
- View/download PDF
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