1. Advancements in the study of IL-6 and its receptors in the pathogenesis of gout.
- Author
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Zhang Z, Wang P, Xiong Q, Xu S, Kang D, He Z, Yao C, and Jian G
- Subjects
- Humans, Animals, Uric Acid metabolism, Inflammation metabolism, Gout metabolism, Interleukin-6 metabolism, Receptors, Interleukin-6 metabolism, Signal Transduction
- Abstract
Gout is an autoinflammatory disease characterized by the deposition of monosodium urate crystals in or around the joints, primarily manifesting as inflammatory arthritis that recurs and resolves spontaneously. Interleukin-6 (IL-6) is a versatile cytokine with both anti-inflammatory and pro-inflammatory capabilities, linked to a variety of inflammatory diseases such as gouty arthritis, rheumatoid arthritis, inflammatory bowel disease, vasculitis, and several types of cancer. The rapid production of IL-6 during infections and tissue damage aids in host defense. However, excessive synthesis of IL-6 and dysregulation of its receptor signaling (IL-6R) might contribute to the pathology of diseases. Recent advancements in clinical and basic research, along with developments in animal models, have established the significant role of IL-6 and its receptors in the pathogenesis of gout, although the precise mechanisms remain to be fully elucidated. This review discusses the role of IL-6 and its receptors in gout progression and examines contemporary research on modulating IL-6 and its signaling pathways for treatment. It aims to provide insights into the pathogenesis of gout and to advance the development of targeted therapies for gout-related inflammation., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Guilin Jian reports administrative support, article publishing charges, statistical analysis, and writing assistance were provided by Suining Third People’s Hospital. Zeng zhang reports a relationship with Suining Third People’s Hospital that includes: employment, funding grants, and non-financial support. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Third People's Hospital of Suining City, Suining City, Sichuan Province, China. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2024
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