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4. Psychiatric and physical outcomes of long-term use of lithium in older adults with bipolar disorder and major depressive disorder: A cross-sectional multicenter study

Author

Adès, J, Alezrah, C, Amado, I, Amar, G, Andréi, O, Arbault, D, Archambault, G, Aurifeuille, G, Barrière, S, Béra-Potelle, C, Blumenstock, Y, Bardou, H, Bareil-Guérin, M, Barrau, P, Barrouillet, C, Baup, E, Bazin, N, Beaufils, B, Ben Ayed, J, Benoit, M, Benyacoub, K, Bichet, T, Blanadet, F, Blanc, O, Blanc-Comiti, J, Boussiron, D, Bouysse, AM, Brochard, A, Brochart, O, Bucheron, B, Cabot, M, Camus, V, Chabannes, JM, Charlot, V, Charpeaud, T, Clad-Mor, C, Combes, C, Comisu, M, Cordier, B, Costi, F, Courcelles, JP, Creixell, M, Cuche, H, Cuervo-Lombard, C, Dammak, A, Da Rin, D, Denis, JB, Denizot, H, Deperthuis, A, Diers, E, Dirami, S, Donneau, D, Dreano, P, Dubertret, C, Duprat, E, Duthoit, D, Fernandez, C, Fonfrede, P, Freitas, N, Gasnier, P, Gauillard, J, Getten, F, Gierski, F, Godart, F, Gourevitch, R, Grassin Delyle, A, Gremion, J, Gres, H, Griner, V, Guerin-Langlois, C, Guggiari, C, Guillin, O, Hadaoui, H, Haffen, E, Hanon, C, Haouzir, S, Hazif-Thomas, C, Heron, A, Hubsch, B, Jalenques, I, Januel, D, Kaladjian, A, Karnycheff, JF, Kebir, O, Krebs, MO, Lajugie, C, Leboyer, M, Legrand, P, Lejoyeux, M, Lemaire, V, Leroy, E, Levy-Chavagnat, D, Leydier, A, Liling, C, Llorca, PM, Loeffel, P, Louville, P, Lucas Navarro, S, Mages, N, Mahi, M, Maillet, O, Manetti, A, Martelli, C, Martin, P, Masson, M, Maurs-Ferrer, I, Mauvieux, J, Mazmanian, S, Mechin, E, Mekaoui, L, Meniai, M, Metton, A, Mihoubi, A, Miron, M, Mora, G, Niro Adès, V, Nubukpo, P, Omnes, C, Papin, S, Paris, P, Passerieux, C, Pellerin, J, Perlbarg, J, Perron, S, Petit, A, Petitjean, F, Portefaix, C, Pringuey, D, Radtchenko, A, Rahiou, H, Raucher-Chéné, D, Rauzy, A, Reinheimer, L, Renard, M, René, M, Rengade, CE, Reynaud, P, Robin, D, Rodrigues, C, Rollet, A, Rondepierre, F, Rousselot, B, Rubingher, S, Saba, G, Salvarelli, JP, Samuelian, JC, Scemama-Ammar, C, Schurhoff, F, Schuster, JP, Sechter, D, Segalas, B, Seguret, T, Seigneurie, AS, Semmak, A, Slama, F, Taisne, S, Taleb, M, Terra, JL, Thefenne, D, Tran, E, Tourtauchaux, R, Vacheron, MN, Vandel, P, Vanhoucke, V, Venet, E, Verdoux, H, Viala, A, Vidon, G, Vitre, M, Vurpas, JL, Wagermez, C, Walter, M, Yon, L, Zendjidjian, X., Morlet, Elise, Costemale-Lacoste, Jean-François, Poulet, Emmanuel, McMahon, Kibby, Hoertel, Nicolas, and Limosin, Frédéric

Published
2019
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5. Effects of depression and cognitive impairment on quality of life in older adults with schizophrenia spectrum disorder: Results from a multicenter study

Author

Adès, J., Alezrah, C., Amado, I., Amar, G., Andréi, O., Arbault, D., Archambault, G., Aurifeuille, G., Barrière, S., Béra-Potelle, C., Blumenstock, Y., Bardou, H., Bareil-Guérin, M., Barrau, P., Barrouillet, C., Baup, E., Bazin, N., Beaufils, B., Ben Ayed, J., Benoit, M., Benyacoub, K., Bichet, T., Blanadet, F., Blanc, O., Blanc-Comiti, J., Boussiron, D., Bouysse, A.M., Brochard, A., Brochart, O., Bucheron, B., Cabot, M., Camus, V., Chabannes, J.M., Charlot, V., Charpeaud, T., Clad-Mor, C., Combes, C., Comisu, M., Cordier, B., Costi, F., Courcelles, J.P., Creixell, M., Cuche, H., Cuervo-Lombard, C., Dammak, A., Da Rin, D., Denis, J.B., Denizot, H., Deperthuis, A., Diers, E., Dirami, S., Donneau, D., Dreano, P., Dubertret, C., Duprat, E., Duthoit, D., Fernandez, C., Fonfrede, P., Freitas, N., Gasnier, P., Gauillard, J., Getten, F., Gierski, F., Godart, F., Gourevitch, R., Grassin Delyle, A., Gremion, J., Gres, H., Griner, V., Guerin-Langlois, C., Guggiari, C., Guillin, O., Hadaoui, H., Haffen, E., Hanon, C., Haouzir, S., Hazif-Thomas, C., Heron, A., Hoertel, N., Hubsch, B., Jalenques, I., Januel, D., Kaladjian, A., Karnycheff, J.F., Kebir, O., Krebs, M.O., Lajugie, C., Leboyer, M., Legrand, P., Lejoyeux, M., Lemaire, V., Leroy, E., Levy-Chavagnat, D., Leydier, A., Liling, C., Limosin, F., Llorca, P.M., Loeffel, P., Louville, P., Lucas Navarro, S., Mages, N., Mahi, M., Maillet, O., Manetti, A., Martelli, C., Martin, P., Masson, M., Maurs-Ferrer, I., Mauvieux, J., Mazmanian, S., Mechin, E., Mekaoui, L., Meniai, M., Metton, A., Mihoubi, A., Miron, M., Mora, G., Niro Adès, V., Nubukpo, P., Omnes, C., Papin, S., Paris, P., Passerieux, C., Pellerin, J., Perlbarg, J., Perron, S., Petit, A., Petitjean, F., Portefaix, C., Pringuey, D., Radtchenko, A., Rahiou, H., Raucher-Chéné, D., Rauzy, A., Reinheimer, L., Renard, M., René, M., Rengade, C.E., Reynaud, P., Robin, D., Rodrigues, C., Rollet, A., Rondepierre, F., Rousselot, B., Rubingher, S., Saba, G., Salvarelli, J.P., Samuelian, J.C., Scemama-Ammar, C., Schurhoff, F., Schuster, J.P., Sechter, D., Segalas, B., Seguret, T., Seigneurie, A.S., Semmak, A., Slama, F., Taisne, S., Taleb, M., Terra, J.L., Thefenne, D., Tran, E., Tourtauchaux, R., Vacheron, M.N., Vandel, P., Vanhoucke, V., Venet, E., Verdoux, H., Viala, A., Vidon, G., Vitre, M., Vurpas, J.L., Wagermez, C., Walter, M., Yon, L., Zendjidjian, X., Pascal de Raykeer, Rachel, Hoertel, Nicolas, Blanco, Carlos, Lavaud, Pierre, Kaladjian, Arthur, Blumenstock, Yvonne, Cuervo-Lombard, Christine-Vanessa, Peyre, Hugo, Lemogne, Cédric, and Limosin, Frédéric

Published
2019
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9. La moindre argumentation des certificats médicaux accroît le risque de mainlevée

Author

Gousset, R., Alamowitch, N., Mache, C., and Gourevitch, R.

Abstract

Bien que la Cour de Cassation ait rappelé que le juge ne pouvait se substituer à l’avis médical, 29,5 % des mainlevées étaient motivées par l’absence de critères d’admission en soins psychiatriques sans consentement (SPSC). Nous avons comparé le contenu des certificats médicaux issus de dossiers de mainlevées justifiées exclusivement par l’absence de critères d’admission à des certificats témoins issus de dossier qui n’ayant pas fait l’objet de mainlevée.

Published
2023
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10. Late-onset and nonlate-onset schizophrenia: A comparison of clinical characteristics in a multicenter study

Author

Passerieux, C., Pellerin, J., Perlbarg, J., Perron, S., Petit, A., Petitjean, F., Portefaix, C., Pringuey, D., Radtchenko, A., Rahiou, H., Raucher-Chene, D., Rauzy, A., Reinheimer, L., Renard, M., Rene, M., Rengade, C. E., Reynaud, P., Robin, D., Rodrigues, C., Rollet, A., Rondepierre, F., Rousselot, B., Rubingher, S., Saba, G., Salvarelli, J. P., Samuelian, J. C., Scemama-Ammar, C., Schurhoff, F., Schuster, J. P., Sechter, D., Segalas, B., Seguret, T., Seigneurie, A. S., Semmak, A., Slama, F., Taisne, S., Taleb, M., Terra, J. L., Thefenne, D., Tran, E., Tourtauchaux, R., Vacheron, M. N., Vanhoucke, V., Venet, E., Verdoux, H., Viala, A., Vidon, G., Vitre, M., Vurpas, J. L., Wagermez, C., Walter, M., Zendjidjian, X., Abou Kassm, Sandra, Limosin, Frederic, Naja, Wadih, Vandel, Pierre, Sanchez-Rico, Marina, Alvarado, Jesus M., Gunten, Armin, Hoertel, Nicolas, Ades, J., Alezrah, C., Amado, I, Amar, G., Andrei, O., Arbault, D., Archambault, G., Aurifeuille, G., Barriere, S., Bera-Potelle, C., Blumenstock, Y., Bardou, H., Bareil-Guerin, M., Barrau, P., Barrouillet, C., Baup, E., Bazin, N., Beaufils, B., Ben Ayed, J., Benoit, M., Benyacoub, K., Bichet, T., Blanadet, F., Blanc, O., Blanc-Comiti, J., Boussiron, D., Bouysse, A. M., Brochard, A., Brochart, O., Bucheron, B., Cabot, M., Camus, V, Chabannes, J. M., Charlot, V, Charpeaud, T., Clad-Mor, C., Combes, C., Comisu, M., Cordier, B., Costi, F., Courcelles, J. P., Creixell, M., Cuche, H., Cuervo-Lombard, C., Dammak, A., da Rin, D., Denis, J. B., Denizot, H., Deperthuis, A., Diers, E., Dirami, S., Donneau, D., Dreano, P., Dubertret, C., Duprat, E., Duthoit, D., Fernandez, C., Fonfrede, P., Freitas, N., Gasnier, P., Gauillard, J., Getten, F., Gierski, Fabien, Godart, F., Gourevitch, R., Delyle, Grassin A., Gremion, J., Gres, H., Griner, V, Guerin-Langlois, C., Guggiari, C., Guillin, O., Hadaoui, H., Haffen, E., Haouzir, S., Hanon, C., Hazif-Thomas, C., Heron, A., Hubsch, B., Jalenques, I, Januel, D., Kaladjian, A., Karnycheff, J. F., Kebir, O., Krebs, M. O., Lajugie, C., Leboyer, M., Legrand, P., Lejoyeux, M., Lemaire, V, Leroy, E., Levy-Chavagnat, D., Leydier, A., Liling, C., Llorca, P. M., Loeffel, P., Louville, P., Navarro, Lucas S., Mages, N., Mahi, M., Maillet, O., Manetti, A., Martelli, C., Martin, P., Masson, M., Maurs-Ferrer, I, Mauvieux, J., Mazmanian, S., Mechin, E., Mekaoui, L., Meniai, M., Metton, A., Mihoubi, A., Miron, M., Mora, G., Ades, Niro, Nubukpo, P., Omnes, C., Papin, S., Paris, P., Fondation FondaMental [Créteil], Weizenbaum Institut [Berlin], Monash University [Clayton], Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804 (CRESTIC), Université de Reims Champagne-Ardenne (URCA), Clinique de Psychiatrie et de Psychologie Médicale, Hôpital Pasteur, Nice, France, Centre Hospitalier Universitaire de Nice (CHU Nice), Cognition, Santé, Société (C2S), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-Maison des Sciences Humaines de Champagne-Ardenne (MSH-URCA), Department of Engineering Cybernetics [Trondheim] (ITK NTNU), Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU)-Norwegian University of Science and Technology (NTNU), Agence nationale de la sécurité des systèmes d'information (ANSSI), Jeune Equipe Hémopathogènes Vectorisés, VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Silicon-on-Insulator Technologies (SOITEC), Parc Technologique des Fontaines, Recherches en Psychopathologie, nouveaux symptômes et lien social (EA 4050), Université de Poitiers-Université de Brest (UBO)-Université Catholique de l'Ouest (UCO)-Université de Rennes 2 (UR2), Research Center for Biosciences and Health Technologies [Lisboa] (CBIOS), Universidade Lusófona's, PHysicochimie des Electrolytes et Nanosystèmes InterfaciauX (PHENIX), Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Modélisation de la matière condensée et des interfaces (MMCI), Institut Lumière Matière [Villeurbanne] (ILM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Kantar – Health Division, Partenaires INRAE, Institut National de la Santé et de la Recherche Médicale (INSERM), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Institut de biologie et chimie des protéines [Lyon] (IBCP), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Soins Primaires, Santé Publique, Registre des cancers de Bretagne Occidentale (EA7479 SPURBO), Université de Brest (UBO)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Service de Psychiatrie, Hôpital de la Conception, Piici, UMR 7298, Aix-Marseille Université-CNRS, Marseille, France, Hôpital Corentin Celton [Issy-les-Moulineaux], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Département de psychiatrie [CHRU de Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), PELLENC S.A., Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire d'Informatique Fondamentale de Lille (LIFL), Université de Lille, Sciences et Technologies-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lille, Sciences Humaines et Sociales-Centre National de la Recherche Scientifique (CNRS), French Society for Biological Psychiatry and Neuropsychopharmacology, CHU Clermont-Ferrand, Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Hôpital Foch [Suresnes], Università degli studi di Genova = University of Genoa (UniGe), Unité de recherche Mathématiques et Informatique Appliquées (MIA), Institut National de la Recherche Agronomique (INRA), Fédération Française de Triathlon (FFTRI), AP-HP, Groupe Hospitalo-Universitaire AP-HP Nord, DMU ESPRIT, service de Psychiatrie et Addictologie, Hôpital Louis Mourier, Colombes, Inserm U1266, 178, rue des Renouillers, 92700 Colombes, France, UFR de Médecine Paris Nord, Université de Paris, 16, rue Henri Huchard, 75018 Paris, France., Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 (GRAP), Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service hospitalo-universitaire, centre hospitalier du Rouvray, 4, rue Paul-Eluard, 76300 Sotteville-lès-Rouen, France., CHRU Brest - Psychiatrie Adulte (CHU - Brest- Psychiatrie), Centre de Physique Théorique [Palaiseau] (CPHT), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Unité de recherche clinique 93G03, établissement public de santé de Ville Evrard, 93330 Neuilly-sur-Marne, France., Laboratoire de Physique des Lasers (LPL), Université Paris 13 (UP13)-Centre National de la Recherche Scientifique (CNRS), Groupement de recherche en Psychiatrie (GDR Psychiatrie (3557)), Centre National de la Recherche Scientifique (CNRS), Université Paris Cité (UPCité), Synchrotron SOLEIL (SSOLEIL), Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), CB - Centre Borelli - UMR 9010 (CB), Service de Santé des Armées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-Université Paris Cité (UPCité), Hôpital Paul Brousse, Digitéo, Génétique Animale et Biologie Intégrative (GABI), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), RiverLy - Fonctionnement des hydrosystèmes (RiverLy), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Sonatrach Exploration, and Centre Hospitalier Victor Jousselin de Dreux

Subjects
Psychosis, Pediatrics, medicine.medical_specialty, business.industry, [SDV]Life Sciences [q-bio], Late onset, Schizoaffective disorder, Comorbidity, Odds ratio, medicine.disease, Psychiatry and Mental health, Cross-Sectional Studies, Psychotic Disorders, Quality of life, Schizophrenia, Quality of Life, medicine, Humans, Geriatrics and Gerontology, business, Aged, Diagnosis of schizophrenia
Abstract

International audience; Objectives Data are scarce regarding the potential clinical differences between non-late onset schizophrenia (NLOS, i.e., disorder occurring before 40 years of age), late-onset schizophrenia (LOS, occurring between ages 40 and 60 years) and very-late-onset schizophrenia-like psychosis (VLOSLP, occurring after 60 years of age). Furthermore, previous research compared LOS patients with non-age matched NLOS patients. In this study, we sought to examine potential clinical differences between patients of similar age with LOS and NLOS. Methods/Design This is a cross-sectional multicentre study that recruited in- and outpatients older adults (aged >= 55 years) with an ICD-10 diagnosis of schizophrenia or schizoaffective disorder with NLOS and LOS. Sociodemographic and clinical characteristics, comorbidity, psychotropic medications, quality of life, functioning, and mental health care utilization were drawn for comparison. Results Two hundred seventy-two participants (79.8%) had NLOS, 61 (17.9%) LOS, and 8 (2.3%) VLOSLP. LOS was significantly and independently associated with greater severity of emotional withdrawal and lower severity of depression (all p < 0.05). However, the magnitude of these associations was modest, with significant adjusted odds ratios ranging from 0.71 to 1.24, and there were no significant between-group differences in other characteristics. Conclusion In an age-matched multicenter sample of elderly patients with schizophrenia, older adults with LOS were largely similar to older adults with NLOS in terms of clinical characteristics. The few differences observed may be at least partially related to symptom fluctuation with time. Implications of these findings for pharmacological and nonpharmacological management is yet to be determined.

Published
2021

13. Psychiatric and physical outcomes of long-term use of lithium in older adults with bipolar disorder and major depressive disorder: A cross-sectional multicenter study

Author

Morlet, Elise, primary, Costemale-Lacoste, Jean-François, additional, Poulet, Emmanuel, additional, McMahon, Kibby, additional, Hoertel, Nicolas, additional, Limosin, Frédéric, additional, Adès, J, additional, Alezrah, C, additional, Amado, I, additional, Amar, G, additional, Andréi, O, additional, Arbault, D, additional, Archambault, G, additional, Aurifeuille, G, additional, Barrière, S, additional, Béra-Potelle, C, additional, Blumenstock, Y, additional, Bardou, H, additional, Bareil-Guérin, M, additional, Barrau, P, additional, Barrouillet, C, additional, Baup, E, additional, Bazin, N, additional, Beaufils, B, additional, Ben Ayed, J, additional, Benoit, M, additional, Benyacoub, K, additional, Bichet, T, additional, Blanadet, F, additional, Blanc, O, additional, Blanc-Comiti, J, additional, Boussiron, D, additional, Bouysse, AM, additional, Brochard, A, additional, Brochart, O, additional, Bucheron, B, additional, Cabot, M, additional, Camus, V, additional, Chabannes, JM, additional, Charlot, V, additional, Charpeaud, T, additional, Clad-Mor, C, additional, Combes, C, additional, Comisu, M, additional, Cordier, B, additional, Costi, F, additional, Courcelles, JP, additional, Creixell, M, additional, Cuche, H, additional, Cuervo-Lombard, C, additional, Dammak, A, additional, Da Rin, D, additional, Denis, JB, additional, Denizot, H, additional, Deperthuis, A, additional, Diers, E, additional, Dirami, S, additional, Donneau, D, additional, Dreano, P, additional, Dubertret, C, additional, Duprat, E, additional, Duthoit, D, additional, Fernandez, C, additional, Fonfrede, P, additional, Freitas, N, additional, Gasnier, P, additional, Gauillard, J, additional, Getten, F, additional, Gierski, F, additional, Godart, F, additional, Gourevitch, R, additional, Grassin Delyle, A, additional, Gremion, J, additional, Gres, H, additional, Griner, V, additional, Guerin-Langlois, C, additional, Guggiari, C, additional, Guillin, O, additional, Hadaoui, H, additional, Haffen, E, additional, Hanon, C, additional, Haouzir, S, additional, Hazif-Thomas, C, additional, Heron, A, additional, Hubsch, B, additional, Jalenques, I, additional, Januel, D, additional, Kaladjian, A, additional, Karnycheff, JF, additional, Kebir, O, additional, Krebs, MO, additional, Lajugie, C, additional, Leboyer, M, additional, Legrand, P, additional, Lejoyeux, M, additional, Lemaire, V, additional, Leroy, E, additional, Levy-Chavagnat, D, additional, Leydier, A, additional, Liling, C, additional, Llorca, PM, additional, Loeffel, P, additional, Louville, P, additional, Lucas Navarro, S, additional, Mages, N, additional, Mahi, M, additional, Maillet, O, additional, Manetti, A, additional, Martelli, C, additional, Martin, P, additional, Masson, M, additional, Maurs-Ferrer, I, additional, Mauvieux, J, additional, Mazmanian, S, additional, Mechin, E, additional, Mekaoui, L, additional, Meniai, M, additional, Metton, A, additional, Mihoubi, A, additional, Miron, M, additional, Mora, G, additional, Niro Adès, V, additional, Nubukpo, P, additional, Omnes, C, additional, Papin, S, additional, Paris, P, additional, Passerieux, C, additional, Pellerin, J, additional, Perlbarg, J, additional, Perron, S, additional, Petit, A, additional, Petitjean, F, additional, Portefaix, C, additional, Pringuey, D, additional, Radtchenko, A, additional, Rahiou, H, additional, Raucher-Chéné, D, additional, Rauzy, A, additional, Reinheimer, L, additional, Renard, M, additional, René, M, additional, Rengade, CE, additional, Reynaud, P, additional, Robin, D, additional, Rodrigues, C, additional, Rollet, A, additional, Rondepierre, F, additional, Rousselot, B, additional, Rubingher, S, additional, Saba, G, additional, Salvarelli, JP, additional, Samuelian, JC, additional, Scemama-Ammar, C, additional, Schurhoff, F, additional, Schuster, JP, additional, Sechter, D, additional, Segalas, B, additional, Seguret, T, additional, Seigneurie, AS, additional, Semmak, A, additional, Slama, F, additional, Taisne, S, additional, Taleb, M, additional, Terra, JL, additional, Thefenne, D, additional, Tran, E, additional, Tourtauchaux, R, additional, Vacheron, MN, additional, Vandel, P, additional, Vanhoucke, V, additional, Venet, E, additional, Verdoux, H, additional, Viala, A, additional, Vidon, G, additional, Vitre, M, additional, Vurpas, JL, additional, Wagermez, C, additional, Walter, M, additional, Yon, L, additional, and Zendjidjian, X., additional

Published
2019
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17. Psychiatric symptoms and quality of life in older adults with schizophrenia spectrum disorder: results from a multicenter study

Author

Pascal de Raykeer, Rachel, Hoertel, Nicolas, Blanco, Carlos, Lavaud, Pierre, Kaladjian, Arthur, Blumenstock, Yvonne, Cuervo-Lombard, Christine-Vanessa, Peyre, Hugo, Lemogne, Cédric, Limosin, Frédéric, Portefaix, C., Adès, J., Alezrah, C., Amado, I., Amar, G., Andréi, O., Arbault, D., Archambault, G., Aurifeuille, G., Barrière, S., Béra-Potelle, C., Bardou, H., Bareil-Guérin, M., Barrau, P., Barrouillet, C., Baup, E., Bazin, N., Beaufils, B., Ben Ayed, J., Benoit, M., Benyacoub, K., Bichet, T., Blanadet, F., Blanc, O., Blanc-Comiti, J., Boussiron, D., Bouysse, A.M., Brochard, A., Brochart, O., Bucheron, B., Cabot, M., Camus, V., Chabannes, J.M., Charlot, V., Charpeaud, T., Clad-Mor, C., Combes, C., Comisu, M., Cordier, B., Costi, F., Courcelles, J.P., Creixell, M., Cuche, H., Dammak, A., Da Rin, D., Denis, J.B., Denizot, H., Deperthuis, A., Diers, E., Dirami, S., Donneau, D., DREANO, P., Dubertret, C., Duprat, E., Duthoit, D., Fernandez, C., Fonfrede, P., Freitas, N., Gasnier, P., Gauillard, J., Getten, F., Gierski, F., Godart, F., Gourevitch, R., Grassin Delyle, A., Gremion, J., Gres, H., Griner, V., Guerin-Langlois, C., Guggiari, C., Guillin, O., Hadaoui, H., Haffen, E., Hanon, Cécile, Haouzir, S., Hazif-Thomas, C., Heron, A., Hubsch, B., Jalenques, I., Januel, D., Karnycheff, J.F., Kebir, O., Krebs, M.O., Lajugie, C., Leboyer, M., Legrand, P., Lejoyeux, M., Lemaire, V., Leroy, E., Levy-Chavagnat, D., Leydier, A., Liling, C., Llorca, P.M., Loeffel, P., Louville, P., Lucas Navarro, S., Mages, N., Mahi, M., Maillet, O., Manetti, A., Martelli, C., Martin, P., Masson, M., Maurs-Ferrer, I., Mauvieux, J., Mazmanian, S., Mechin, E., Mekaoui, L., Meniai, M., Metton, A., Mihoubi, A., Miron, M., MORA, G., Niro Adès, V., Nubukpo, P., Omnes, C., Papin, S., Paris, P., Passerieux, C., Pellerin, J., Perlbarg, J., Perron, S., Petit, A., Petitjean, F., Pringuey, D., Radtchenko, A., Rahiou, H., Raucher-Chéné, D., Rauzy, A., Reinheimer, L., Renard, M., René, M., Rengade, C.E., Reynaud, P., Robin, D., Rodrigues, C., Rollet, A., Rondepierre, F., Rousselot, B., Rubingher, S., Saba, G., Salvarelli, J.P., Samuelian, J.C., Scemama-Ammar, C., Schurhoff, F., Schuster, J.P., Sechter, D., Segalas, B., Seguret, T., Seigneurie, A.S., Semmak, A., Slama, F., Taisne, S., Taleb, M., Terra, J.L., Thefenne, D., Tran, E., Tourtauchaux, R., Vacheron, M.N., Vandel, P., Vanhoucke, V., Venet, E., Verdoux, H., Viala, A., Vidon, G., Vitre, M., Vurpas, J.L., Wagermez, C., Walter, M., Yon, L., Zendjidjian, X., Rotenberg, Léa, Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804 (CRESTIC), Université de Reims Champagne-Ardenne (URCA), Department of Radiology, Maison Blanche Hospital, Université Reims-Champagne-Ardenne, 45, rue Cognacq-Jay, 51092 Reims, France, and Centre Hospitalier Universitaire de Reims (CHU Reims)

Subjects
Male, medicine.medical_specialty, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Population, Psychological intervention, Schizoaffective disorder, Psychiatric Department, Hospital, Neuropsychological Tests, 03 medical and health sciences, 0302 clinical medicine, Quality of life, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Brief Psychiatric Rating Scale, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, Pharmacology (medical), Cognitive Dysfunction, education, Psychiatry, Biological Psychiatry, ComputingMilieux_MISCELLANEOUS, Aged, Aged, 80 and over, education.field_of_study, business.industry, General Medicine, Middle Aged, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Schizophrenia, Cohort, Disease Progression, Quality of Life, Female, France, business, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Psychopathology, Follow-Up Studies
Abstract

The severity of psychopathology has a strong negative impact on quality of life (QoL) among older adults with schizophrenia spectrum disorder. However, because these subjects generally experience multiple psychiatric symptoms, it remains unclear whether decreased QoL in this population is due to specific symptoms (e.g., hallucinations), specific dimensions of psychopathology (e.g., negative symptoms), a general psychopathology dimension representing the shared effect across all psychiatric symptoms, or a combination of these explanations. Data were derived from the Cohort of individuals with Schizophrenia Aged 55 years or more (CSA) study, a large (N = 353) multicenter sample of older adults with schizophrenia spectrum disorder recruited from French public-sector psychiatric departments. We used structural equation modeling to examine the shared and specific effects of psychiatric symptoms on QoL, while adjusting for sociodemographic characteristics, general medical conditions, global cognitive functioning and psychotropic medications. Psychiatric symptoms and QoL were assessed face-to-face by psychiatrists using the Brief Psychiatric Rating Scale (BPRS) and the Quality of Life Scale (QLS). Among older adults with schizophrenia spectrum disorder, effects of psychiatric symptoms on QoL were exerted mostly through a general psychopathology dimension (β = − 0.43, p

Published
2018

19. Effects of depression and cognitive impairment on quality of life in older adults with schizophrenia spectrum disorder: Results from a multicenter study

Author

Pascal de Raykeer, Rachel, primary, Hoertel, Nicolas, additional, Blanco, Carlos, additional, Lavaud, Pierre, additional, Kaladjian, Arthur, additional, Blumenstock, Yvonne, additional, Cuervo-Lombard, Christine-Vanessa, additional, Peyre, Hugo, additional, Lemogne, Cédric, additional, Limosin, Frédéric, additional, Adès, J., additional, Alezrah, C., additional, Amado, I., additional, Amar, G., additional, Andréi, O., additional, Arbault, D., additional, Archambault, G., additional, Aurifeuille, G., additional, Barrière, S., additional, Béra-Potelle, C., additional, Blumenstock, Y., additional, Bardou, H., additional, Bareil-Guérin, M., additional, Barrau, P., additional, Barrouillet, C., additional, Baup, E., additional, Bazin, N., additional, Beaufils, B., additional, Ben Ayed, J., additional, Benoit, M., additional, Benyacoub, K., additional, Bichet, T., additional, Blanadet, F., additional, Blanc, O., additional, Blanc-Comiti, J., additional, Boussiron, D., additional, Bouysse, A.M., additional, Brochard, A., additional, Brochart, O., additional, Bucheron, B., additional, Cabot, M., additional, Camus, V., additional, Chabannes, J.M., additional, Charlot, V., additional, Charpeaud, T., additional, Clad-Mor, C., additional, Combes, C., additional, Comisu, M., additional, Cordier, B., additional, Costi, F., additional, Courcelles, J.P., additional, Creixell, M., additional, Cuche, H., additional, Cuervo-Lombard, C., additional, Dammak, A., additional, Da Rin, D., additional, Denis, J.B., additional, Denizot, H., additional, Deperthuis, A., additional, Diers, E., additional, Dirami, S., additional, Donneau, D., additional, Dreano, P., additional, Dubertret, C., additional, Duprat, E., additional, Duthoit, D., additional, Fernandez, C., additional, Fonfrede, P., additional, Freitas, N., additional, Gasnier, P., additional, Gauillard, J., additional, Getten, F., additional, Gierski, F., additional, Godart, F., additional, Gourevitch, R., additional, Grassin Delyle, A., additional, Gremion, J., additional, Gres, H., additional, Griner, V., additional, Guerin-Langlois, C., additional, Guggiari, C., additional, Guillin, O., additional, Hadaoui, H., additional, Haffen, E., additional, Hanon, C., additional, Haouzir, S., additional, Hazif-Thomas, C., additional, Heron, A., additional, Hoertel, N., additional, Hubsch, B., additional, Jalenques, I., additional, Januel, D., additional, Kaladjian, A., additional, Karnycheff, J.F., additional, Kebir, O., additional, Krebs, M.O., additional, Lajugie, C., additional, Leboyer, M., additional, Legrand, P., additional, Lejoyeux, M., additional, Lemaire, V., additional, Leroy, E., additional, Levy-Chavagnat, D., additional, Leydier, A., additional, Liling, C., additional, Limosin, F., additional, Llorca, P.M., additional, Loeffel, P., additional, Louville, P., additional, Lucas Navarro, S., additional, Mages, N., additional, Mahi, M., additional, Maillet, O., additional, Manetti, A., additional, Martelli, C., additional, Martin, P., additional, Masson, M., additional, Maurs-Ferrer, I., additional, Mauvieux, J., additional, Mazmanian, S., additional, Mechin, E., additional, Mekaoui, L., additional, Meniai, M., additional, Metton, A., additional, Mihoubi, A., additional, Miron, M., additional, Mora, G., additional, Niro Adès, V., additional, Nubukpo, P., additional, Omnes, C., additional, Papin, S., additional, Paris, P., additional, Passerieux, C., additional, Pellerin, J., additional, Perlbarg, J., additional, Perron, S., additional, Petit, A., additional, Petitjean, F., additional, Portefaix, C., additional, Pringuey, D., additional, Radtchenko, A., additional, Rahiou, H., additional, Raucher-Chéné, D., additional, Rauzy, A., additional, Reinheimer, L., additional, Renard, M., additional, René, M., additional, Rengade, C.E., additional, Reynaud, P., additional, Robin, D., additional, Rodrigues, C., additional, Rollet, A., additional, Rondepierre, F., additional, Rousselot, B., additional, Rubingher, S., additional, Saba, G., additional, Salvarelli, J.P., additional, Samuelian, J.C., additional, Scemama-Ammar, C., additional, Schurhoff, F., additional, Schuster, J.P., additional, Sechter, D., additional, Segalas, B., additional, Seguret, T., additional, Seigneurie, A.S., additional, Semmak, A., additional, Slama, F., additional, Taisne, S., additional, Taleb, M., additional, Terra, J.L., additional, Thefenne, D., additional, Tran, E., additional, Tourtauchaux, R., additional, Vacheron, M.N., additional, Vandel, P., additional, Vanhoucke, V., additional, Venet, E., additional, Verdoux, H., additional, Viala, A., additional, Vidon, G., additional, Vitre, M., additional, Vurpas, J.L., additional, Wagermez, C., additional, Walter, M., additional, Yon, L., additional, and Zendjidjian, X., additional

Published
2019
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23. Antipsychotiques atypiques et syndrome malin des neuroleptiques: une brève revue de la littérature

Author

Khaldi, Slim, Kornreich, Charles, Choubani, Z., Gourevitch, R., Khaldi, Slim, Kornreich, Charles, Choubani, Z., and Gourevitch, R.

Abstract

Background: Neuroleptic malignant syndrome (NMS) is an uncommon, but potentially life threatening complication of neuroleptic drugs. In 1960, Delay et al. [Ann Med Psychol 118 (1960) 145-152] described the "syndrome akinétique hypertonique"(hypertonic akinetic syndrome) and its cardinal symptoms: hyperthermia, extrapyramidal symptoms, altered mental status and autonomic dysfunctions. The syndrome often develops after a sudden increase in dose of neuroleptic medication or in states of dehydration. The frequency of NMS with conventional neuroleptic drugs ranges from 0.02 to 3.3%. The pathophysiology of NMS is not clearly understood. It has been suggested that the potential to induce NMS of neuroleptics is parallel to the potency of dopamine blockade in the nigrostriatal tract, mesocortical pathway and hypothalamic nuclei. It is, however, intriguing that NMS may appear with atypical antipsychotics (AA) and especially clozapine (CLZ), which is mainly characterized by its low affinity to D1 and D2 receptors. Objective: The purpose of this study was to review cases of NMS induced by AA agents reported in the literature and to discuss the pathophysiology of this complication. Methods: Cases of NMS related to AA were collected by means of a MEDLINE literature search between January 1986 and June 2005. As key words we used: (NMS and AA), amisulpride (AMS), clozapine (CLZ), olanzapine (OLZ), risperidone (RIS), quetiapine (QTP), ziprazidone (ZPS) and side effects. For the purpose of our review, all cases were critically examined against standard NMS diagnostic criteria according to DSM-IV. Cases involving a coprescription of classical neuroleptics were excluded. Results: Our search yielded 47 cases (eight women, 39 men) of NMS associated with AA meeting DSM-IV criteria. Patients' mean age was 37 years, primary patient diagnoses were schizophrenia (n = 26), schizoaffective disorder (n = 9), bipolar disorder (n = 3), mental retardation (n = 4) and other diagnoses (n = 5). Drugs, SCOPUS: sh.j, info:eu-repo/semantics/published

Published
2008

36. Évaluation comparative de la qualité de vie de patients schizophrènes traités par neuroleptiques classiques et neuroleptiques atypiques : résultats d’une étude transversale

Author

Divanon, F., primary, Delamillieure, P., additional, Lehaguez, A., additional, Vasse, T., additional, Morello, R., additional, Gourevitch, R., additional, Langlois, S., additional, Assouly-Besse, F., additional, Guelfi, J.D., additional, Petit, M., additional, and Dollfus, S., additional

Published
2006
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43. Mes de nacimiento en pacientes esquizofrénicos con y sin déficit

Author

Dollfus, S., primary, Brazo, P., additional, Langlois, S., additional, Gourevitch, R., additional, Dassa, D., additional, Besse, F., additional, Van Der Elst, A., additional, Thibaut, F., additional, Delamillieure, P., additional, Chabot, B., additional, Guelfi, J. D., additional, and Petit, M., additional

Published
2000
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44. Month of birth in deficit and non-deficit schizophrenic patients

Author

Dollfus, S., primary, Brazo, P., additional, Langlois, S., additional, Gourevitch, R., additional, Dassa, D., additional, Besse, F., additional, Van Der Elst, A., additional, Thibaut, F., additional, Delamillieure, P., additional, Chabot, B., additional, Guelfi, J.D., additional, and Petit, M., additional

Published
1999
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48. Characteristics of older patients in the largest French psychiatric emergency centre.

Author

Pham-Scottez A, Gallarda T, Calvez M, Silva J, Barruel D, Masson VD, Lahaye J, Perquier F, Sarazin M, and Gourevitch R

Abstract

Despite an increasing number of adults older than 60 years with psychiatric disorders, there are few studies on older patients in psychiatric emergencies and no European data. We aimed to describe the population of patients aged 60 years and older who presented to the main French psychiatric emergency centre and identify predictors of psychiatric hospitalization. This monocentric study included 300 consecutive patients aged 60 years and older. Patients presenting because of psychiatric emergencies were frequently female and lived autonomously. More than 40% had a history of at least one psychiatric hospitalization and 44% had consulted a psychiatrist in the previous 6 months. The most common reasons for consultation were depression, anxiety, sleep disorders and suicidal thoughts. Psychiatric disorders were mainly mood disorders; neurotic, stress-related and somatoform disorders; and schizophrenic, schizotypal and delusional disorders. Only 10% had a diagnosis of organic mental disorders. Overall, 39% of the patients were admitted to the psychiatric hospital. Factors predicting hospitalization were a history of psychiatric hospitalization, suicidal thoughts and a diagnosis of a mood disorder or schizophrenia/schizotypal/delusional disorder. In conclusion, among people aged 60 years and older who consulted for psychiatric emergencies, 39% had to be hospitalized in psychiatry and only psychiatric factors influenced the decision to hospitalize. Our study highlights the need for further studies of older people in psychiatric emergencies in Europe, to anticipate the needs of this specific population and adapt multidisciplinary mental health care., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Pham-Scottez, Gallarda, Calvez, Silva, Barruel, Dauriac-Le Masson, Lahaye, Perquier, Sarazin and Gourevitch.)

Published
2023
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50. [Failure to draw up medical certificates increase judiciary releases].

Author

Gousset R, Alamowitch N, Mache C, and Gourevitch R

Subjects
Humans, France, Paris, Antisocial Personality Disorder, Commitment of Mentally Ill, Hospitalization
Abstract

Objectives: In France, a systematic control of compulsory psychiatric admissions has existed since the enactment of the law of July 5th 2011. The Court of Cassation clarified that the liberty and custody judges (JLD) cannot supersede the medical opinion described in the medical certificates. In 2015, the JLD ordered the release of 8.4 % of all compulsory psychiatric admissions. The goal was to compare the quality of medical certificates derived from judicial release based on medical grounds with non-released witnesses from the cohort of compulsory psychiatric admissions ordered in the Groupe Hospitalier Universitaire Paris Psychiatrie & Neurosciences (GHU-Paris) between November 1, 2017 and October 31, 2018., Methods: We included as cases all the medical certificates derived from judicial release based exclusively on medical grounds from the release cohort of the GHU-Paris from November 1, 2017 to October 31, 2018, concerning the systematic control 12 days after compulsory psychiatric admissions. A witness whose compulsory care had been maintained was matched according to the same judge, place and date of hearing, mode of compulsory care and site of hospitalization. Each certificate was analyzed according to a reading grid relating to the good decisions in matters of compulsory admission and medical certificates' redaction. An overall score, based on the description of the clinical and symptomatic evolution, the level of discernment, the capacity of consent and the mode of compulsory care was awarded to each certificate., Results: Seventeen release files were included in the comparative study. Globally, the clinical progression, psychiatric symptoms, level of consciousness and ability to consent did not differ in the two groups. The grade of quality of certificate was lower in case of withdrawal (2.92±1.08 VS 3.28±0.88, P=0.026). Psychiatric symptoms in "justifiable notice" (the last medical certificate prior to the judicial hearing) were less specified in case of withdrawal (58.8 % VS 94.1 %, P=0.015). Not describing any symptoms led to a 12.51 risk of withdrawal (95 % CI=[1.16; 135.19], P=0.038). Even with witness certificate, clinical progression was noticed in only 85.3 % of cases, in 89.3 % of psychiatric symptoms, in 68.0 % of level of consciousness and 80.0 % for the ability to consent., Conclusions: Judiciary releases of compulsory psychiatric admissions exclusively based on medical grounds are not arbitrarily decided by the JLD but are based on a failure to draw up medical certificates. Doctors must comply with a careful drafting of all medical certificates: description of symptoms, clinical course, level of consciousness and ability to consent. It is necessary to be attentive to judiciary releases based on medical grounds to evaluate and improve medical practices concerning the drafting of medical certificates., (Copyright © 2022 L'Encéphale, Paris. Published by Elsevier Masson SAS. All rights reserved.)

Published
2023
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