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1. Netrin-1 blockade inhibits tumor associated Myeloid-derived suppressor cells, cancer stemness and alleviates resistance to chemotherapy and immune checkpoint inhibitor

Author

Ducarouge, Benjamin, Redavid, Anna-Rita, Victoor, Camille, Chira, Ruxanda, Fonseca, Aurélien, Hervieu, Maëva, Bergé, Roméo, Lengrand, Justine, Vieugué, Pauline, Neves, David, Goddard, Isabelle, Richaud, Mathieu, Laval, Pierre-Alexandre, Rama, Nicolas, Goldschneider, David, Paradisi, Andrea, Gourdin, Nicolas, Chabaud, Sylvie, Treilleux, Isabelle, Gadot, Nicolas, Ray-Coquard, Isabelle, Depil, Stéphane, Decaudin, Didier, Némati, Fariba, Marangoni, Elisabetta, Mery-Lamarche, Eliane, Génestie, Catherine, Tabone-Eglinger, Séverine, Devouassoux-Shisheboran, Mojgan, Moore, Kathryn J., Gibert, Benjamin, Mehlen, Patrick, and Bernet, Agnes

Published
2023
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2. Control of acute myeloid leukemia by a trifunctional NKp46-CD16a-NK cell engager targeting CD123

Author

Gauthier, Laurent, Virone-Oddos, Angela, Beninga, Jochen, Rossi, Benjamin, Nicolazzi, Céline, Amara, Céline, Blanchard-Alvarez, Audrey, Gourdin, Nicolas, Courta, Jacqueline, Basset, Alexandra, Agnel, Magali, Guillot, Franceline, Grondin, Gwendoline, Bonnevaux, Hélène, Bauchet, Anne-Laure, Morel, Ariane, Morel, Yannis, Chiron, Marielle, and Vivier, Eric

Published
2023
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3. Antitumor immunity induced by antibody-based natural killer cell engager therapeutics armed with not-alpha IL-2 variant

Author

Demaria, Olivier, Gauthier, Laurent, Vetizou, Marie, Blanchard Alvarez, Audrey, Vagne, Constance, Habif, Guillaume, Batista, Luciana, Baron, William, Belaïd, Nourhène, Girard-Madoux, Mathilde, Cesari, Cedric, Caratini, Melody, Bosco, Frédéric, Benac, Olivier, Lopez, Julie, Fenis, Aurore, Galluso, Justine, Trichard, Sylvia, Carrette, Barbara, Carrette, Florent, Maguer, Aurélie, Jaubert, Solène, Sansaloni, Audrey, Letay-Drouet, Robin, Kosthowa, Camille, Lovera, Naouel, Dujardin, Arnaud, Chanuc, Fabien, Le Van, Mélanie, Bokobza, Sivan, Jarmuzynski, Nicolas, Fos, Camille, Gourdin, Nicolas, Remark, Romain, Lechevallier, Eric, Fakhry, Nicolas, Salas, Sébastien, Deville, Jean-Laurent, Le Grand, Roger, Bonnafous, Cécile, Vollmy, Lukas, Represa, Agnès, Carpentier, Sabrina, Rossi, Benjamin, Morel, Ariane, Cornen, Stéphanie, Perrot, Ivan, Morel, Yannis, and Vivier, Eric

Published
2022
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4. Abstract 2960: The novel trifunctional anti-BCMA NK cell engager SAR’514 has potent in-vitro, in-vivo and ex-vivo anti-myeloma effect through dual NK cell engagement

Author

Tang, Alexandre, primary, Gauthier, Laurent, additional, Beninga, Jochen, additional, Rossi, Benjamin, additional, Gourdin, Nicolas, additional, Blanchard-Alvarez, Audrey, additional, Amara, Céline, additional, Courta, Jacqueline, additional, Basset, Alexandra, additional, Bourges, Dorothée, additional, Desjonqueres, Alexandre, additional, Menoret, Emmanuelle, additional, Pellat-Deceunynck, Catherine, additional, Moreau, Philippe, additional, Morel, Yannis, additional, Chiron, Marielle, additional, Vivier, Eric, additional, and Virone-Oddos, Angela, additional

Published
2023
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5. Supplementary methods from Autocrine Adenosine Regulates Tumor Polyfunctional CD73+CD4+ Effector T Cells Devoid of Immune Checkpoints

Author

Gourdin, Nicolas, primary, Bossennec, Marion, primary, Rodriguez, Céline, primary, Vigano, Selena, primary, Machon, Christelle, primary, Jandus, Camilla, primary, Bauché, David, primary, Faget, Julien, primary, Durand, Isabelle, primary, Chopin, Nicolas, primary, Tredan, Olivier, primary, Marie, Julien C., primary, Dubois, Bertrand, primary, Guitton, Jérôme, primary, Romero, Pedro, primary, Caux, Christophe, primary, and Ménétrier-Caux, Christine, primary

Published
2023
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6. Figure S5 from Autocrine Adenosine Regulates Tumor Polyfunctional CD73+CD4+ Effector T Cells Devoid of Immune Checkpoints

Author

Gourdin, Nicolas, primary, Bossennec, Marion, primary, Rodriguez, Céline, primary, Vigano, Selena, primary, Machon, Christelle, primary, Jandus, Camilla, primary, Bauché, David, primary, Faget, Julien, primary, Durand, Isabelle, primary, Chopin, Nicolas, primary, Tredan, Olivier, primary, Marie, Julien C., primary, Dubois, Bertrand, primary, Guitton, Jérôme, primary, Romero, Pedro, primary, Caux, Christophe, primary, and Ménétrier-Caux, Christine, primary

Published
2023
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7. Data from Autocrine Adenosine Regulates Tumor Polyfunctional CD73+CD4+ Effector T Cells Devoid of Immune Checkpoints

Author

Gourdin, Nicolas, primary, Bossennec, Marion, primary, Rodriguez, Céline, primary, Vigano, Selena, primary, Machon, Christelle, primary, Jandus, Camilla, primary, Bauché, David, primary, Faget, Julien, primary, Durand, Isabelle, primary, Chopin, Nicolas, primary, Tredan, Olivier, primary, Marie, Julien C., primary, Dubois, Bertrand, primary, Guitton, Jérôme, primary, Romero, Pedro, primary, Caux, Christophe, primary, and Ménétrier-Caux, Christine, primary

Published
2023
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8. The Novel Trifunctional Anti-BCMA NK Cell Engager SAR'514 Has Potent in-Vitro and in-Vivo Anti-Myeloma Effect through Dual NK Cell Engagement

Author

Tang, Alexandre, primary, Gauthier, Laurent, additional, Beninga, Jochen, additional, Rossi, Benjamin, additional, Gourdin, Nicolas, additional, Blanchard-Alvarez, Audrey, additional, Amara, Céline, additional, Courta, Jacqueline, additional, Basset, Alexandra, additional, Bourges, Dorothee, additional, Desjonqueres, Alexandre, additional, Menoret, Emmanuelle, additional, Pellat-Deceunynck, Catherine, additional, Moreau, Philippe, additional, Morel, Yannis, additional, Chiron, Marielle, additional, Virone-Oddos, Angela, additional, and Vivier, Eric, additional

Published
2022
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9. Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis

Author

Carvelli, Julien, Demaria, Olivier, Vély, Frédéric, Batista, Luciana, Chouaki Benmansour, Nassima, Fares, Joanna, Carpentier, Sabrina, Thibult, Marie-Laure, Morel, Ariane, Remark, Romain, André, Pascale, Represa, Agnès, Piperoglou, Christelle, Assante Miranda, Laura, Baron, William, Belaid, Nourhène, Caillet, Clarisse, Caraguel, Flavien, Carrette, Barbara, Carrette, Florent, Chanuc, Fabien, Courtois, Rachel, Fenis, Aurore, Giordano, Marilyn, Girard-Madoux, Mathilde, Giraudon-Paoli, Marc, Gourdin, Nicolas, Grondin, Gwendoline, Guillot, Franceline, Habif, Guillaume, Jaubert, Solène, Lopez, Julie, Le Van, Mélanie, Lovera, Naouel, Mansuy, Marine, Bonnet, Elodie, Sansaloni, Audrey, Reboul, Annick, Mitry, Emmanuel, Nekkar-Constant, Camille, Péri, Valentine, Ricaut, Paul, Simon, Léa, Vallier, Jean-Baptiste, Vétizou, Marie, Zerbib, Robert, Ugolini, Sophie, Etiennot, Marion, Galluso, Justine, Lyonnet, Luc, Forel, Jean-Marie, Papazian, Laurent, Velly, Lionel, André, Baptiste, Briantais, Antoine, Faucher, Benoit, Jean, Estelle, Seguier, Julie, Veit, Veronique, Harlé, Jean-Robert, Pastorino, Boris, Delteil, Clémence, Daniel, Laurent, Boudsocq, Jean-Paul, Clerc, Axelle, Delmond, Emmanuel, Vidal, Pierre-Olivier, Savini, Hélène, Coutard, Bruno, Cordier, Pierre Yves, Le Dault, Erwan, Guervilly, Christophe, Simeone, Pierre, Gainnier, Marc, Morel, Yannis, Ebbo, Mikael, Schleinitz, Nicolas, and Vivier, Eric

Subjects
0301 basic medicine, Acute Lung Injury, Complement C5a, Inflammation, Complement factor I, Lung injury, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, Animals, Humans, Myeloid Cells, Lung, Receptor, Anaphylatoxin C5a, Respiratory Distress Syndrome, CD11b Antigen, Multidisciplinary, medicine.diagnostic_test, SARS-CoV-2, business.industry, COVID-19, respiratory system, Pathophysiology, 3. Good health, Complement system, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Bronchoalveolar lavage, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Immunology, Female, medicine.symptom, Cytokine Release Syndrome, business, Bronchoalveolar Lavage Fluid
Abstract

Coronavirus disease 2019 (COVID-19) is a disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in a pandemic1. The C5a complement factor and its receptor C5aR1 (also known as CD88) have a key role in the initiation and maintenance of several inflammatory responses by recruiting and activating neutrophils and monocytes1. Here we provide a longitudinal analysis of immune responses, including phenotypic analyses of immune cells and assessments of the soluble factors that are present in the blood and bronchoalveolar lavage fluid of patients at various stages of COVID-19 severity, including those who were paucisymptomatic or had pneumonia or acute respiratory distress syndrome. The levels of soluble C5a were increased in proportion to the severity of COVID-19 and high expression levels of C5aR1 receptors were found in blood and pulmonary myeloid cells, which supports a role for the C5a-C5aR1 axis in the pathophysiology of acute respiratory distress syndrome. Anti-C5aR1 therapeutic monoclonal antibodies prevented the C5a-mediated recruitment and activation of human myeloid cells, and inhibited acute lung injury in human C5aR1 knock-in mice. These results suggest that blockade of the C5a-C5aR1 axis could be used to limit the infiltration of myeloid cells in damaged organs and prevent the excessive lung inflammation and endothelialitis that are associated with acute respiratory distress syndrome in patients with COVID-19.

Published
2020
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11. 852 Trifunctional NKp46/CD16a-NK cell engager targeting CD123 overcomes acute myeloid leukemia resistance to ADCC

Author

Gauthier, Laurent, primary, Virone-Oddos, Angela, additional, Beninga, Jochen, additional, Rossi, Benjamin, additional, Nicolazzi, Céline, additional, Amara, Céline, additional, Blanchard-Alvarez, Audrey, additional, Gourdin, Nicolas, additional, Courta, Jacqueline, additional, Basset, Alexandra, additional, Guillot, Franceline, additional, Grondin, Gwendoline, additional, Bonnevaux, Hélène, additional, Bauchet, Anne-Laure, additional, Morel, Ariane, additional, Morel, Yannis, additional, Chiron, Marielle, additional, and Vivier, Eric, additional

Published
2021
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12. Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies

Author

Perrot, Ivan, primary, Michaud, Henri-Alexandre, additional, Giraudon-Paoli, Marc, additional, Augier, Séverine, additional, Docquier, Aurélie, additional, Gros, Laurent, additional, Courtois, Rachel, additional, Déjou, Cécile, additional, Jecko, Diana, additional, Becquart, Ondine, additional, Rispaud-Blanc, Hélène, additional, Gauthier, Laurent, additional, Rossi, Benjamin, additional, Chanteux, Stéphanie, additional, Gourdin, Nicolas, additional, Amigues, Beatrice, additional, Roussel, Alain, additional, Bensussan, Armand, additional, Eliaou, Jean-François, additional, Bastid, Jérémy, additional, Romagné, François, additional, Morel, Yannis, additional, Narni-Mancinelli, Emilie, additional, Vivier, Eric, additional, Paturel, Carine, additional, and Bonnefoy, Nathalie, additional

Published
2019
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13. Abstract 2718: Preclinical development of humanized CD39 and CD73 blocking antibodies targeting the ATP/adenosine immune checkpoint pathway for cancer immunotherapy

Author

Perrot, Ivan, primary, Paoli, Marc Giraudon, additional, Augier, Séverine, additional, Blemont, Marilyne Royannez, additional, Gaudin, Marion, additional, Bosco, Frédéric, additional, Courtois, Rachel, additional, Delahaye, Stephane, additional, Jecko, Diana, additional, Gourdin, Nicolas, additional, Agu, Maryline Salin, additional, Perrier, Cyril, additional, Ricaut, Paul, additional, Docquier, Aurélie, additional, Chanteux, Stéphanie, additional, Rossi, Benjamin, additional, Représa, Agnès, additional, Denis, Caroline, additional, Remark, Romain, additional, Bonnafous, Cécile, additional, Gauthier, Laurent, additional, Morel, Ariane, additional, Bonnefoy, Nathalie, additional, Bastid, Jérémy, additional, Morel, Yannis, additional, and Paturel, Carine, additional

Published
2018
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14. Autocrine Adenosine Regulates Tumor Polyfunctional CD73+CD4+ Effector T Cells Devoid of Immune Checkpoints

Author

Gourdin, Nicolas, primary, Bossennec, Marion, additional, Rodriguez, Céline, additional, Vigano, Selena, additional, Machon, Christelle, additional, Jandus, Camilla, additional, Bauché, David, additional, Faget, Julien, additional, Durand, Isabelle, additional, Chopin, Nicolas, additional, Tredan, Olivier, additional, Marie, Julien C., additional, Dubois, Bertrand, additional, Guitton, Jérôme, additional, Romero, Pedro, additional, Caux, Christophe, additional, and Ménétrier-Caux, Christine, additional

Published
2018
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15. Abstract 2344: Discovery and characterization of new original blocking antibodies targeting the CD73 immune checkpoint for cancer immunotherapy

Author

Giraudon Paoli, Marc, primary, Augier, Severine, additional, Royannez Blemont, Marilyne, additional, Rodriguez, Céline, additional, Rispaud Blanc, Hélène, additional, Chanteux, Stéphanie, additional, Gourdin, Nicolas, additional, Gauthier, Laurent, additional, Ménétrier Caux, Christine, additional, Morel, Yannis, additional, Caux, Christophe, additional, Paturel, Carine, additional, and Perrot, Ivan, additional

Published
2016
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17. Autocrine Adenosine Regulates Tumor Polyfunctional CD73 + CD4 + Effector T Cells Devoid of Immune Checkpoints.

Author

Gourdin N, Bossennec M, Rodriguez C, Vigano S, Machon C, Jandus C, Bauché D, Faget J, Durand I, Chopin N, Tredan O, Marie JC, Dubois B, Guitton J, Romero P, Caux C, and Ménétrier-Caux C

Subjects
Antineoplastic Agents, Immunological pharmacology, Antineoplastic Agents, Immunological therapeutic use, Apyrase metabolism, Breast Neoplasms drug therapy, Breast Neoplasms pathology, Costimulatory and Inhibitory T-Cell Receptors antagonists & inhibitors, Costimulatory and Inhibitory T-Cell Receptors metabolism, Drug Resistance, Neoplasm immunology, Female, GPI-Linked Proteins metabolism, Humans, Interleukin-17 metabolism, Lymphocytes, Tumor-Infiltrating immunology, Lymphocytes, Tumor-Infiltrating metabolism, Ovarian Neoplasms drug therapy, Ovarian Neoplasms pathology, T-Lymphocytes, Helper-Inducer metabolism, T-Lymphocytes, Regulatory immunology, T-Lymphocytes, Regulatory metabolism, 5'-Nucleotidase metabolism, Adenosine metabolism, Breast Neoplasms immunology, Ovarian Neoplasms immunology, T-Lymphocytes, Helper-Inducer immunology, Tumor Escape immunology
Abstract

The production of CD73-derived adenosine (Ado) by Tregs has been proposed as a resistance mechanism to anti-PD-1 therapy in murine tumor models. We reported that human Tregs express the ectonucleotidase CD39, which generates AMP from ATP, but do not express the AMPase CD73. In contrast, CD73 defined a subset of effector CD4 + T cells (Teffs) enriched in polyfunctional Th1.17 cells characterized by expression of CXCR3, CCR6, and MDR1, and production of IL17A/IFNγ/IL22/GM-CSF. CD39 + Tregs selectively targeted CD73 + Teffs through cooperative degradation of ATP into Ado inhibiting and restricting the ability of CD73 + Teffs to secrete IL17A. CD73 + Teffs infiltrating breast and ovarian tumors were functionally blunted by Tregs expressing upregulated levels of CD39 and ATPase activity. Moreover, tumor-infiltrating CD73 + Teffs failed to express inhibitory immune checkpoints, suggesting that CD73 might be selected under pressure from immune checkpoint blockade therapy and thus may represent a nonredundant target for restoring antitumor immunity. Significance: Polyfunctional CD73 + T-cell effectors lacking other immune checkpoints are selectively targeted by CD39 overexpressing Tregs that dominate the breast tumor environment. Cancer Res; 78(13); 3604-18. ©2018 AACR ., (©2018 American Association for Cancer Research.)

Published
2018
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