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6. Supplementary Table 3 from A Genome-Wide Association Study Identifies a Novel Locus for Bortezomib-Induced Peripheral Neuropathy in European Patients with Multiple Myeloma

Author

Magrangeas, Florence, primary, Kuiper, Rowan, primary, Avet-Loiseau, Hervé, primary, Gouraud, Wilfried, primary, Guérin-Charbonnel, Catherine, primary, Ferrer, Ludovic, primary, Aussem, Alexandre, primary, Elghazel, Haytham, primary, Suhard, Jérôme, primary, Der Sakissian, Henri, primary, Attal, Michel, primary, Munshi, Nikhil C., primary, Sonneveld, Pieter, primary, Dumontet, Charles, primary, Moreau, Philippe, primary, van Duin, Mark, primary, Campion, Loïc, primary, and Minvielle, Stéphane, primary

Published
2023
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7. Supplementary Table 4 from A Genome-Wide Association Study Identifies a Novel Locus for Bortezomib-Induced Peripheral Neuropathy in European Patients with Multiple Myeloma

Author

Magrangeas, Florence, primary, Kuiper, Rowan, primary, Avet-Loiseau, Hervé, primary, Gouraud, Wilfried, primary, Guérin-Charbonnel, Catherine, primary, Ferrer, Ludovic, primary, Aussem, Alexandre, primary, Elghazel, Haytham, primary, Suhard, Jérôme, primary, Der Sakissian, Henri, primary, Attal, Michel, primary, Munshi, Nikhil C., primary, Sonneveld, Pieter, primary, Dumontet, Charles, primary, Moreau, Philippe, primary, van Duin, Mark, primary, Campion, Loïc, primary, and Minvielle, Stéphane, primary

Published
2023
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8. Supplementary Figures from A Genome-Wide Association Study Identifies a Novel Locus for Bortezomib-Induced Peripheral Neuropathy in European Patients with Multiple Myeloma

Author

Magrangeas, Florence, primary, Kuiper, Rowan, primary, Avet-Loiseau, Hervé, primary, Gouraud, Wilfried, primary, Guérin-Charbonnel, Catherine, primary, Ferrer, Ludovic, primary, Aussem, Alexandre, primary, Elghazel, Haytham, primary, Suhard, Jérôme, primary, Der Sakissian, Henri, primary, Attal, Michel, primary, Munshi, Nikhil C., primary, Sonneveld, Pieter, primary, Dumontet, Charles, primary, Moreau, Philippe, primary, van Duin, Mark, primary, Campion, Loïc, primary, and Minvielle, Stéphane, primary

Published
2023
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9. Supplementary Table 2 from A Genome-Wide Association Study Identifies a Novel Locus for Bortezomib-Induced Peripheral Neuropathy in European Patients with Multiple Myeloma

Author

Magrangeas, Florence, primary, Kuiper, Rowan, primary, Avet-Loiseau, Hervé, primary, Gouraud, Wilfried, primary, Guérin-Charbonnel, Catherine, primary, Ferrer, Ludovic, primary, Aussem, Alexandre, primary, Elghazel, Haytham, primary, Suhard, Jérôme, primary, Der Sakissian, Henri, primary, Attal, Michel, primary, Munshi, Nikhil C., primary, Sonneveld, Pieter, primary, Dumontet, Charles, primary, Moreau, Philippe, primary, van Duin, Mark, primary, Campion, Loïc, primary, and Minvielle, Stéphane, primary

Published
2023
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10. Supplementary Table 1 from A Genome-Wide Association Study Identifies a Novel Locus for Bortezomib-Induced Peripheral Neuropathy in European Patients with Multiple Myeloma

Author

Magrangeas, Florence, primary, Kuiper, Rowan, primary, Avet-Loiseau, Hervé, primary, Gouraud, Wilfried, primary, Guérin-Charbonnel, Catherine, primary, Ferrer, Ludovic, primary, Aussem, Alexandre, primary, Elghazel, Haytham, primary, Suhard, Jérôme, primary, Der Sakissian, Henri, primary, Attal, Michel, primary, Munshi, Nikhil C., primary, Sonneveld, Pieter, primary, Dumontet, Charles, primary, Moreau, Philippe, primary, van Duin, Mark, primary, Campion, Loïc, primary, and Minvielle, Stéphane, primary

Published
2023
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11. Abstract P5-02-37: Multi-omics approach to identify markers of resistance to endocrine therapy + CDK4/6 inhibitors in first line HR+/HER2- metastatic breast cancer (MBC) patients

Author

FRENEL, Jean Sebastien, primary, Azzouz, Fadoua Ben, additional, Bigot, Frederic, additional, Dauve, Jonathan, additional, Heymann, Marie Francoise, additional, Gouraud, Wilfried, additional, Guette, Catherine, additional, Lasla, Hamza, additional, Michel, Bertrand, additional, Morel, Alain, additional, Patsouris, Anne, additional, Robert, Marie, additional, Siekaniec, Grégoire, additional, Colombie, Mathilde, additional, Jézéquel, Pascal, additional, and Campone, Mario, additional

Published
2023
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19. Development of an absolute assignment predictor for triple-negative breast cancer subtyping using machine learning approaches

Author

Azzouz, Fadoua Ben, primary, Michel, Bertrand, additional, Lasla, Hamza, additional, Gouraud, Wilfried, additional, François, Anne-Flore, additional, Girka, Fabien, additional, Lecointre, Théo, additional, Guérin-Charbonnel, Catherine, additional, Juin, Philippe P., additional, Campone, Mario, additional, and Jézéquel, Pascal, additional

Published
2020
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22. Additional file 18: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

External TNBC cohort’s clinicopathologic characteristics in function of the three clusters (C’1, C’2, and C’3). (PDF 136 kb)

Published
2019
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23. Additional file 29: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Subjects
body regions, nervous system, fungi
Abstract

Proposed therapeutic strategies in function of GES and robust subtyping results. (PDF 162 kb)

Published
2019
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24. Additional file 5: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Fuzzy clustering of 238 TNBC. Distribution of patients based on probability of belonging to cluster: C1, n = 55 (blue); C2, n = 98 (red) and C3, n = 85 (green). Each vertex of the triangle represents a cluster and each point represents a patient, placed as the barycenter of the triangle, weights being the probabilities of belonging to each of the clusters. The closer a point is to one of the vertices, the greater is the probability of the patient to belong to the corresponding cluster. (PDF 86 kb)

Published
2019
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25. Additional file 3: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Subjects
body regions, nervous system, fungi
Abstract

Details of antibodies used for immunohistochemistry. (PDF 84 kb)

Published
2019
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26. Additional file 4: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Projection of internal TNBC cohorts in the first PCA plane. (A) PACS08 patients (n = 131, [orange]) compared to TNBC patients of a previous study (n = 107, [black]). (B) Each color represents a recruitment site, except for grayish pale green color, which represents one or two patients recruited in different sites (n = 36 patients; 28 sites). Total number of recruitment sites was equal to 45. (PDF 95 kb)

Published
2019
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27. Additional file 9: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Categorical GES analyses result in function of internal TNBC clusters (C1, C2, and C3). (PDF 107 kb)

Published
2019
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28. Additional file 6: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Event-free survival analysis of TNBC pooled cohort. This cohort is composed of 427 patients from internal (n = 238) and external (n = 189) cohorts (C1 & C’1 [blue]; C2 & C’2 [red] and C3 & C’3 [green]). (PDF 141 kb)

Published
2019
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29. Additional file 7: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

Projection of internal TNBC cohort in the first PCA plane. (C1, n = 55 [blue]; C2, n = 98 [red]; C3, n = 85 [green]). (PDF 88 kb)

Published
2019
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30. Additional file 8: of Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Author

Jézéquel, Pascal, Kerdraon, Olivier, Hondermarck, Hubert, Guérin-Charbonnel, Catherine, Lasla, Hamza, Gouraud, Wilfried, Canon, Jean-Luc, Gombos, Andrea, Dalenc, Florence, Delaloge, Suzette, Lemonnier, Jérôme, Loussouarn, Delphine, Verrièle, Véronique, and Campone, Mario

Abstract

PCA of internal TNBC cohort. Lists of PC1 and PC2 twenty highest absolute weight probes. (PDF 115 kb)

Published
2019
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31. RUBY: A phase II study testing rucaparib in germline (g) BRCA wild-type patients presenting metastatic breast cancer (mBC) with homologous recombination deficiency (HRD).

Author

Patsouris, Anne, primary, Tredan, Olivier, additional, Nenciu, Daniel, additional, Tran-Dien, Alicia, additional, Campion, Loic, additional, Goncalves, Anthony, additional, Arnedos, Monica, additional, Sablin, Marie-Paule, additional, Gouraud, Wilfried, additional, Jimenez, Marta, additional, Droin, Nathalie, additional, Bieche, Ivan, additional, Callens, Celine, additional, Loehr, Andrea, additional, Vicier, Cecile, additional, and Andre, Fabrice, additional

Published
2019
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33. c-Myc dependent expression of pro-apoptotic Bim renders HER2-overexpressing breast cancer cells dependent on anti-apoptotic Mcl-1

Author

Jézéquel Pascal, Campion Loïc, Charbonnel Catherine, Gouraud Wilfried, Gautier Fabien, Guillemin Yannis, Grau Morgan, Couriaud Cécile, Noël Bélinda, Campone Mario, Braun Frédérique, Barré Benjamin, Coqueret Olivier, Barillé-Nion Sophie, and Juin Philippe

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Anti-apoptotic signals induced downstream of HER2 are known to contribute to the resistance to current treatments of breast cancer cells that overexpress this member of the EGFR family. Whether or not some of these signals are also involved in tumor maintenance by counteracting constitutive death signals is much less understood. To address this, we investigated what role anti- and pro-apoptotic Bcl-2 family members, key regulators of cancer cell survival, might play in the viability of HER2 overexpressing breast cancer cells. Methods We used cell lines as an in vitro model of HER2-overexpressing cells in order to evaluate how anti-apoptotic Bcl-2, Bcl-xL and Mcl-1, and pro-apoptotic Puma and Bim impact on their survival, and to investigate how the constitutive expression of these proteins is regulated. Expression of the proteins of interest was confirmed using lysates from HER2-overexpressing tumors and through analysis of publicly available RNA expression data. Results We show that the depletion of Mcl-1 is sufficient to induce apoptosis in HER2-overexpressing breast cancer cells. This Mcl-1 dependence is due to Bim expression and it directly results from oncogenic signaling, as depletion of the oncoprotein c-Myc, which occupies regions of the Bim promoter as evaluated in ChIP assays, decreases Bim levels and mitigates Mcl-1 dependence. Consistently, a reduction of c-Myc expression by inhibition of mTORC1 activity abrogates occupancy of the Bim promoter by c-Myc, decreases Bim expression and promotes tolerance to Mcl-1 depletion. Western blot analysis confirms that naïve HER2-overexpressing tumors constitutively express detectable levels of Mcl-1 and Bim, while expression data hint on enrichment for Mcl-1 transcripts in these tumors. Conclusions This work establishes that, in HER2-overexpressing tumors, it is necessary, and maybe sufficient, to therapeutically impact on the Mcl-1/Bim balance for efficient induction of cancer cell death.

Published
2011
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34. A Genome-Wide Association Study Identifies a Novel Locus for Bortezomib-Induced Peripheral Neuropathy in European Multiple Myeloma Patients

Author

Magrangeas, Florence, Kuiper, Rowan, Avet-Loiseau, Hervé, Gouraud, Wilfried, Guérin-Charbonnel, Catherine, Ferrer, Ludovic, Aussem, Alexandre, Elghazel, Haytham, Suhard, Jérôme, Der Sakissian, Henri, Attal, Michel, Munshi, Nikhil, Sonneveld, Pieter, Dumontet, Charles, Moreau, Philippe, Van Duin, Mark, Campion, Loïc, Minvielle, Stéphane, Centre de Recherche en Cancérologie / Nantes - Angers (CRCNA), Centre hospitalier universitaire de Nantes (CHU Nantes)-Faculté de Médecine d'Angers-Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Centre National de la Recherche Scientifique (CNRS)-Hôpital Laennec-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôtel-Dieu de Nantes, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de cancérologie de l'Ouest - Nantes (ICO Nantes), CRLCC Paul Papin-CRLCC René Gauducheau, Data Mining and Machine Learning (DM2L), Laboratoire d'InfoRmatique en Image et Systèmes d'information (LIRIS), Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Institut de Cancérologie de l'Ouest, Institut de Recherche en Communications et en Cybernétique de Nantes (IRCCyN), Mines Nantes (Mines Nantes)-École Centrale de Nantes (ECN)-Ecole Polytechnique de l'Université de Nantes (Polytech Nantes), Université de Nantes (UN)-Université de Nantes (UN)-PRES Université Nantes Angers Le Mans (UNAM)-Centre National de la Recherche Scientifique (CNRS), CHU Toulouse [Toulouse], Lebow Institute of Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Harvard Medical School [Boston] (HMS), Boston Veterans Administration Healthcare System, West Roxbury, Centre de Recherche en Cancérologie de Lyon (CRCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), This study was supported by Intergroupe Francophone du Myélome, the French Institute National du Cancer Grant POBNIMM PROG/08/10 (to H.A.L., S.M.), and National Institutes of Health Grant PO1CA155258-01 (to S.M., H.A.L., N.C.M.)., Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École Centrale de Lyon (ECL), Université de Lyon-Université Lumière - Lyon 2 (UL2)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Université Lumière - Lyon 2 (UL2), Mines Nantes (Mines Nantes)-École Centrale de Nantes (ECN)-Ecole Polytechnique de l'Université de Nantes (EPUN), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.CAN]Life Sciences [q-bio]/Cancer
Abstract

International audience; Purpose: Painful peripheral neuropathy is a frequent toxicity associated with bortezomib therapy.This study aimed to identify loci that affect susceptibility to this toxicity.Experimental Design: A genome-wide association study (GWAS) of 370,605 SNPs wasperformed to identify risk variants for developing severe bortezomib-induced peripheral neuropathy(BiPN) in 469 multiple myeloma (MM) patients who received bortezomib-dexamethasone therapyprior to autologous stem-cell in randomized clinical trials of the Intergroupe Francophone duMyelome (IFM) and findings were replicated in 114 MM patients of the HOVON-65/GMMG-HD4clinical trial.Results: A single SNP in the PKNOX1 gene was associated with BiPN in the exploratory cohort(rs2839629; OR, 1.89, 95% CI: [1.45-2.44]; P = 7.6 x 10-6) and in the replication cohort (OR, 2.04;95% CI = [1.11-3.33]; P= 8.3 x 10-3). In addition, rs2839629 is in strong linkage disequilibrium (r2= 0.87) with rs915854, located in the intergenic region between PKNOX1 and CBS . Expressionquantitative trait loci mapping showed that both rs2839629 and rs915854 genotypes impactPKNOX1 expression in nerve tissue while rs2839629 affects CBS expression in skin and blood.Conclusions: The use of GWAS in MM pharmacogenomics has identified a novel candidate geneticlocus mapping to PKNOX1 and in the immediate vicinity of CBS at 21q22.3 associated with thesevere bortezomib-induced toxicity. The proximity of these two genes involved in neurologic painwhose tissue-specific expression is modified by the two variants provides new targets for neuroprotectivestrategies.

Published
2016

35. Logic programming reveals alteration of key transcription factors in multiple myeloma

Author

Miannay, Bertrand, primary, Minvielle, Stéphane, additional, Roux, Olivier, additional, Drouin, Pierre, additional, Avet-Loiseau, Hervé, additional, Guérin-Charbonnel, Catherine, additional, Gouraud, Wilfried, additional, Attal, Michel, additional, Facon, Thierry, additional, Munshi, Nikhil C, additional, Moreau, Philippe, additional, Campion, Loïc, additional, Magrangeas, Florence, additional, and Guziolowski, Carito, additional

Published
2017
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36. An open-label, phase II study of rucaparib, a PARP inhibitor, in HER2- metastatic breast cancer patients with high genomic loss of heterozygosity: RUBY.

Author

Patsouris, Anne, primary, Vicier, Cecile, additional, Campion, Loic, additional, Gouraud, Wilfried, additional, Jimenez, Marta, additional, Pezzella, Veronica, additional, Loehr, Andrea, additional, Raponi, Mitch, additional, Bieche, Ivan, additional, Callens, Celine, additional, and Andre, Fabrice, additional

Published
2017
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37. Additional file 6: of Gene-expression signature functional annotation of breast cancer tumours in function of age

Author

Jézéquel, Pascal, Sharif, Zein, Lasla, Hamza, Gouraud, Wilfried, Guérin-Charbonnel, Catherine, Campion, Loïc, Chrétien, Stéphane, and Campone, Mario

Abstract

GO biological process enrichment analyses of most differentially expressed genes between AG1 and AG3. Head of columns represents SAM gene lists used as ToppGene inputs. The ten first significant biological processes are displayed (cutoff p-value = 0.01). (PDF 45 kb)

Published
2015
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42. Additional file 2: of Gene-expression signature functional annotation of breast cancer tumours in function of age

Author

Jézéquel, Pascal, Sharif, Zein, Lasla, Hamza, Gouraud, Wilfried, Guérin-Charbonnel, Catherine, Campion, Loïc, Chrétien, Stéphane, and Campone, Mario

Subjects
musculoskeletal diseases, congenital, hereditary, and neonatal diseases and abnormalities, animal structures, macromolecular substances, skin and connective tissue diseases
Abstract

Metastasis-free survival (MFS) and overall survival (OS) analyses. MFS: 2A1: whole cohort; 2A2: Caucasian cohort. OS: 2B1: whole cohort; 2B2: Caucasian cohort. (PDF 230 kb)

Published
2015
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45. Additional file 3: of Gene-expression signature functional annotation of breast cancer tumours in function of age

Author

Jézéquel, Pascal, Sharif, Zein, Lasla, Hamza, Gouraud, Wilfried, Guérin-Charbonnel, Catherine, Campion, Loïc, Chrétien, Stéphane, and Campone, Mario

Abstract

GES scoring of breast cancer in function of age. Correlation matrices show Pearson correlation coefficients between continuous GES (red indicates a positive correlation; blue, a negative correlation) and dendrograms show mutual relationships of all signatures (scores were used for average-link hierarchical clustering using the Pearson correlation as a distance metric). 2A1: AG1, whole cohort; 2A2: AG2, whole cohort; 2A3: AG3 whole cohort; 2B1: AG1, Caucasian cohort; 2B2: AG2, Caucasian cohort; 2B3: AG3, Caucasian cohort. (PDF 1689 kb)

Published
2015
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46. A Genome-Wide Association Study Identifies a Novel Locus for Bortezomib-Induced Peripheral Neuropathy in European Patients with Multiple Myeloma

Author

Magrangeas, Florence, primary, Kuiper, Rowan, additional, Avet-Loiseau, Hervé, additional, Gouraud, Wilfried, additional, Guérin-Charbonnel, Catherine, additional, Ferrer, Ludovic, additional, Aussem, Alexandre, additional, Elghazel, Haytham, additional, Suhard, Jérôme, additional, Der Sakissian, Henri, additional, Attal, Michel, additional, Munshi, Nikhil C., additional, Sonneveld, Pieter, additional, Dumontet, Charles, additional, Moreau, Philippe, additional, van Duin, Mark, additional, Campion, Loïc, additional, and Minvielle, Stéphane, additional

Published
2016
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48. Abstract P2-04-07: Gene-expression molecular subtyping of immunohistochemistry-typed triple-negative breast cancer tumours

Author

Campone, Mario, primary, Campion, Loïc, additional, Loussouarn, Delphine, additional, Valo, Isabelle, additional, Guérin-Charbonnel, Catherine, additional, Vanier, Antoine, additional, Gouraud, Wilfried, additional, Guette, Catherine, additional, Verrièle, Véronique, additional, Chassevent, Agnès, additional, and Jézéquel, Pascal, additional

Published
2015
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49. Gene-expression molecular subtyping of triple-negative breast cancer tumours: importance of immune response

Author

Jézéquel, Pascal, primary, Loussouarn, Delphine, additional, Guérin-Charbonnel, Catherine, additional, Campion, Loïc, additional, Vanier, Antoine, additional, Gouraud, Wilfried, additional, Lasla, Hamza, additional, Guette, Catherine, additional, Valo, Isabelle, additional, Verrièle, Véronique, additional, and Campone, Mario, additional

Published
2015
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50. A Genome Wide Association Study Reveals Genetic Predisposition for Bortezomib-Induced Peripheral Neuropathy in Multiple Myeloma By Variation in the PREP1-Cbs Locus

Author

Magrangeas, Florence, primary, Kuiper, Rowan, additional, Avet-loiseau, Hervé, additional, Gouraud, Wilfried, additional, Guérin, Catherine, additional, Der Sakissian, Henri, additional, Suhard, Jérôme, additional, Attal, Michel, additional, Sonneveld, Pieter, additional, Dumontet, Charles, additional, Moreau, Philippe, additional, van Duin, Mark, additional, Campion, Loic, additional, and Minvielle, Stephane, additional

Published
2014
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