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5. Facteurs pronostiques de l’atteinte rénale au cours du Purpura Rhumatoïde de l’adulte au Centre Hospitalier et Universitaire de Tunis / Pronostic factors of Henoch Schönlein nephritis in Tunis university hospital: Pronostic factors of Henoch Schönlein nephritis in Tunis university hospital

Author

Jerbi, Mouna, Achouch, Sonia, Aloui, Amira, Khadhar, Mariem, Gaied, Hanene, Chargui, Soumaya, Gorsane, Imen, Aoudia, Raja, Goucha, Rym, and Ben Abdallah, Taleb

Subjects
Purpura rhumatoïde, adulte, néphropathie, Maladie Rénale Chronique stade 5, pronostic, Henoch-schönlein purpura, adult, nephritis, histology, prognosis
Abstract

Context and objective. IgA vasculitis is a leukocytoclastic vasculitis with IgA deposits characterized by the association of cutaneous, articular and digestive involvements. Renal involvement worsens the pronostic of the disease. The main objective of this work was to identify the risk factors of end-stage renal failure in Tunisian adults with IgA vasculitis.Methods. From 1975 to 2017, patients with IgA vasculitis and nephritis were studied retrospectively. All the patients benefited from a renal biopsy classified histologically according to Pillebout.Results. Thirty-four adult patients (mean age at nephritis onset: 39 ± 17.6y) mainly men, were included. Risk factors for progression to end stage renal disease were: edema (p=0.002), oligoanuria (p=0.003), initial renal impairment (p=0.001), anemia (p=0.010), hyperuricemia (p=0.015), class IV (p=0.018), crescents (p=0.018) and interstitial fibrosis (p=0.017).Conclusion. The outcome of renal involvement during IgA vasculitis is relatively poor. Renal involvement conditions the long-term prognosis of the disease. The identification of clinical, biological and histological risk factors of end stage renal failure would improve its management. Contexte et objectif. Le purpura rhumatoïde est une vascularite leucocytoclasique à dépôts d’IgA caractérisée par l’association de signes cutanés, articulaires et digestifs. L’atteinte rénale fait la gravité de la maladie. Le principal objectif de ce travail était d’identifier les facteurs prédictifs de la maladie rénale chronique stade 5 chez des patients ayant un Purpura Rhumatoïde avec atteinte rénale.Méthodes. Nous avons étudié de façon rétrospective les observations de patients ayant présenté un purpura rhumatoïde avec atteinte rénale colligés de 1975 à 2017. Les lésions histologiques ont été classées selon la classification de Pillebout.Résultats. Nous avons colligé 34 patients adultes atteints de Purpura Rhumatoïde avec atteinte rénale. L’âge moyen des patients était de 39 ± 17,6 ans avec une prédominance masculine. Les facteurs prédictifs de la Maladie Rénale Chronique stade 5 étaient : les œdèmes (p=0,002), l’oligoanurie (p=0,003), l’insuffisance rénale initiale (p=0,001), l’anémie (p=0,010), l’hyperuricémie (p=0,015), la classe histologique IV (p=0,018), les croissants (p=0,009) et la fibrose interstitielle (p=0,017).Conclusion. L’atteinte rénale au cours du Purpura Rhumatoïde conditionne le pronostic à long terme. Sa recherche doit être systématique afin de prévenir ou de ralentir l’évolution vers la maladie rénale chronique stade 5.

Published
2021

6. MO202RITUXIMAB TREATMENT IN NEPHROLOGY

Author

Malki abidi, Mouna, primary, Barbouch, Samia, additional, Mariem, Hajji, additional, Mesbahi, Tasnim, additional, Harzallah, Amel, additional, Gorsane, Imen, additional, Hafedh, Hedri, additional, Kaaroud, Hayet, additional, Goucha, Rym, additional, and Ben hmida, Fethi, additional

Published
2021
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8. HYPERTENSION IN IGA NEPHROPATHY WITH MICROANGIOPATHY

Author

Mannai, Khouloud, primary, Gaied, Hanene, additional, Jerbi, Mouna, additional, Trabelsi, Raja Aoudia, additional, Bacha, Mongi, additional, Harzallah, Amal, additional, Gorsane, Imen, additional, Abderrahim, Ezzeddine, additional, Goucha, Rym, additional, and Abdallah, Taieb Ben, additional

Published
2021
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9. DOES MICROANGIOPATHY INFLUENCE ARTERIAL PRESSURE IN IGA NEPHROPATHY?

Author

Mannai, Khouloud, primary, Hajri, Malika, additional, Gaied, Hanene, additional, Jerbi, Mouna, additional, Harzallah, Amel, additional, Bacha, Mouhamed Mongi, additional, Trabelsi, Raja, additional, Lounissi, Mondher, additional, Barbouch, Samia, additional, Hedri, Hafedh, additional, Kaaroud, Hayet, additional, Laabidi, Jannet, additional, Abderrahim, Ezzeddine, additional, Hmida, Fathi Ben, additional, Younsi, Fethi El, additional, Goucha, Rym, additional, and Abdallah, Taieb Ben, additional

Published
2021
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13. P0318HYPERKALEMIA: EPIDEMIOLOGY AND MANAGEMENT

Author

Felah, Eya, primary, Samia, Barbouch, primary, Mariem, Hajji, primary, Ben amor, Shedha, primary, Chargui, Soumaya, primary, Amiri, Mohamed lotfi, primary, Trabelsi, Raja, primary, Goucha, Rym, primary, Ben Hmida, Fethi, primary, Ounissi, Mondher, primary, and Ben abdallah, Taieb, primary

Published
2020
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18. LUPUS NEPHRITIS IN CHILDREN

Author

Moussa, Fatma Ben, Kaaroud, Hayet, Barbouche, Samia, Goucha, Rym, Beji, Soumaya, and Maiz, Hedi Ben

Published
2003

24. SP055LIGHT CHAIN DEPOSITS DISEASE FROM 19 KIDNEY BIOPSIES

Author

Aoudia, Raja, primary, Azaiez, Seif, additional, Jaziri, Fatima, additional, Chaabouni, Emna, additional, Chargui, Soumaya, additional, Gaied, Hanene, additional, Jerbi, Mouna, additional, Bacha, Mohamed Mongi, additional, Ounissi, Mondher, additional, Hedri, Hafedh, additional, Ben Abdallah, Taieb, additional, and Goucha, Rym, additional

Published
2018
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27. MP281ETIOLOGIC PROFILE OF ACUTE INTERSTITIAL NEPHRITIS

Author

Gorsane Imen, Hajji Meriam, Harzallah Amel, Ben Hamida Fethi, Ben Abdallah Taieb, Goucha Rym, and Kaaroud Hayet

Subjects
Transplantation, Pathology, medicine.medical_specialty, Acute interstitial nephritis, Nephrology, business.industry, Medicine, business
Published
2017

33. Light chain nephropathy

Author

Darouich, Sihem, primary, Bettaieb, Ilhem, additional, Hedri, Hafedh, additional, Goucha, Rym, additional, Khedher, Adel, additional, Abderrahim, Ezzeddine, additional, and Aouadia, Raja, additional

Published
2015
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38. Acute renal failure by ingestion of Euphorbia paralias

Author

Boubaker, Karima, primary, Ounissi, Mondher, additional, Brahmi, Nozha, additional, Goucha, Rym, additional, Hedri, Hafedh, additional, Abdellah, TaiebBen, additional, El Younsi, Fethi, additional, Maiz, HediBen, additional, and Kheder, Adel, additional

Published
2013
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39. Risk factors and consequences of delayed graft function

Author

Ounissi, Mondher, primary, Kheder, Adel, additional, Slama, RiadhBen, additional, Sfar, Imen, additional, Abdallah, TaiebBen, additional, Abderrahim, Ezzedine, additional, Cherif, Mejda, additional, Bacha, Mongi, additional, Hedri, Hafedh, additional, Goucha, Rym, additional, Derouiche, Amine, additional, Chebil, Mohamed, additional, Bardi, Rafika, additional, and Gorgi, Yosr, additional

Published
2013
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48. Focal segmental glomerulosclerosis in children.

Author

Jellouli M, Abidi K, Askri M, Ferjani M, Naija O, Hammi Y, Goucha R, and Gargah T

Subjects
Adolescent, Child, Child, Preschool, Cyclophosphamide therapeutic use, Cyclosporine therapeutic use, Female, Glomerulosclerosis, Focal Segmental drug therapy, Glomerulosclerosis, Focal Segmental physiopathology, Humans, Infant, Male, Mycophenolic Acid therapeutic use, Nephrotic Syndrome drug therapy, Prognosis, Remission Induction, Retrospective Studies, Tunisia, Glomerulosclerosis, Focal Segmental epidemiology, Glucocorticoids therapeutic use, Immunosuppressive Agents therapeutic use
Abstract

Background Focal segmental glomerulosclerosis (FSGS) represents 20% of nephrotic syndrome in children. The clinical course and prognosis is heterogeneous in children. The aim of this study was to analyze treatment and outcome of children with FSGS. Methods This retrospective study was conducted in the Department of Pediatrics in Charles Nicolle Hospital during a 15-year period (1996-2010). Results There were 30 children, 16 boys and 14 girls. The mean age was 7 ± 4 years. Nephrotic syndrome was observed in 26 patients, hematuria was noticed in 2 patients and renal insufficiency was detected in 2 patients at presentation. FSGS, not otherwise specified, was the predominant variant. All patients with nephrotic syndrome were treated with steroids. Only three patients responded to it. Twenty one patients were treated with cisclosporin A and this resulted in a 57% complete remission and a 24% partial response. Cyclophosphamide was administered to 6 patients and engendered a 50% complete remission. Six patients were treated with mycophenolate mophetil and showed no response in all cases. Renal insufficiency has been developed in 12 children. Conclusion Results from this study showed that the majority of children with FSGS achieve a high sustained remission rate with ciclosporine A.

Published
2016

50. [Renal AA amyloidosis during Langerhans' cell histiocytosis: case report].

Author

Ounissi M, Fouda HD, Hedri H, Boubaker K, Barbouch S, Bacha MM, Goucha R, Abderrahim E, Ben Maiz H, and Kheder A

Subjects
Adult, Amyloidosis pathology, Fatal Outcome, Histiocytosis, Langerhans-Cell pathology, Humans, Kidney Diseases pathology, Male, Amyloidosis complications, Histiocytosis, Langerhans-Cell complications, Kidney Diseases complications
Published
2013

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