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1. Direct Determination of Spin-Splitting Energy in Magnetic Graphene by Landau Fan Shifts

Author

Hu, J. X., Han, Y. L., Chi, X., Omar, G. J., Ezzi, M. M. Al, Tan, J. Y., Gou, J., Yu, X. J., Watanabe, K., Taniguchi, T., Wee, A. T. S., Qiao, Z. H., and Ariando, A.

Subjects
Condensed Matter - Materials Science, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Spin-polarized two-dimensional materials with large and tunable spin-splitting energy promise the field of 2D spintronics. While graphene has been a canonical 2D material, its spin properties and tunability are limited. Here, we demonstrate the emergence of robust spin-polarization in graphene with large and tunable spin-splitting energy of up to 132 meV at zero applied magnetic fields. The spin polarization is induced through a magnetic exchange interaction between graphene and the underlying ferrimagnetic oxide insulating layer, Tm3Fe5O12, as confirmed by its X-ray magnetic circular dichroism. The spin-splitting energies are directly measured and visualized by the shift in their landau fan diagram mapped by analyzing the measured subnikov-de-Haas oscillations as a function of applied electric fields, showing consistent fit with our first-principles and machine learning calculations. Further, the observed spin-splitting energies can be tuned over a broad range between 98 and 166 meV by cooling fields. Our methods and results are applicable to other two-dimensional (magnetic) materials and heterostructures, and offer great potential for developing next-generation spin logic and memory devices.

Published
2022

2. Room-temperature colossal magnetoresistance in terraced single-layer graphene

Author

Hu, J. X., Gou, J., Yang, M., Omar, G. J., Tan, J. Y., Zeng, S. W., Liu, Y. P., Han, K., Lim, Z. S., Huang, Z., Wee, A. T. S., and Ariando, A.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science, Condensed Matter - Strongly Correlated Electrons
Abstract

Disorder-induced magnetoresistance (MR) effect is quadratic at low perpendicular magnetic fields and linear at high fields. This effect is technologically appealing, especially in the two-dimensional (2D) materials such as graphene, since it offers potential applications in magnetic sensors with nanoscale spatial resolution. However, it is a great challenge to realize a graphene magnetic sensor based on this effect because of the difficulty in controlling the spatial distribution of disorder and enhancing the MR sensitivity in the single-layer regime. Here, we report a room-temperature colossal MR of up to 5,000% at 9 T in terraced single-layer graphene. By laminating single-layer graphene on a terraced substrate, such as TiO2 terminated SrTiO3, we demonstrate a universal one order of magnitude enhancement in the MR compared to conventional single-layer graphene devices. Strikingly, a colossal MR of >1,000% was also achieved in the terraced graphene even at a high carrier density of ~1012 cm-2. Systematic studies of the MR of single-layer graphene on various oxide- and non-oxide-based terraced surfaces demonstrate that the terraced structure is the dominant factor driving the MR enhancement. Our results open a new route for tailoring the physical property of 2D materials by engineering the strain through a terraced substrate., Comment: 64 pages; Main 31 pages, 4 figures; Supplementary 33 pages, 18 figures

Published
2021
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3. Stokes polarimetric imaging and applications to novel materials

Author

Gou, J.

Subjects
620.1
Abstract

In this thesis, a dual photo elastic modulator-based Stokes polarimetric method for polarization measurement is described, which forms the basis of the operation of a prototype polarimetric microscope. The operational characteristics of the microscope have been characterized in this study and optimized. The polarimetric imaging technique has been applied to the study of four material systems, namely, micropipe defects in SiC, a pinhole, liquid crystal droplets, and nanograter structures. The thesis includes ten chapters, which provide the description of polarization, literature review of the research, the methodology of the Stokes polarimetry and its calibration, computer automation of the measurements and the characterization and the optimization of the performance of the Stokes polarimetric microscope, a detailed study of the polarimetric images of micropipes and their strain fields in SiC wafers, a pinhole in a metallic film, and the polarization characteristics of liquid crystal droplets, the polarization characteristics of plasmonic nanograter structures on gold film. This polarization state is sensitive to the structure of a material. Under the assumption of a plane wave, the local electrical field is obtained. This microscope realizes mapping the full polarization states in area widefield setting with high sensitivity and good spatial resolution under a single optical setup. A set of experimental parameters, such as the ambient temperature, light source construction, and polarization angle setting, have been optimized; as well as, the optical alignments, data analysis method, and image acquisition program implemented to provide an efficient operation of the microscope. The mapping of the polarization parameter provides a new way to research the characteristics of material; It also provides vector data for understanding the behavior of the interaction between light and materials. The work demonstrates that the Stokes polarimetric imaging method is useful and may have potential applications in a wide range of research fields.

Published
2021

5. Emergence and Genetic Characterization of Plasmid-Encoded VIM-2-Producing Pseudomonas stutzeri with Novel Integron In1998 Isolated from Cerebrospinal Fluid

Author

Liu S, Xu H, Guo X, Li S, Wang Q, Li Y, Liu R, and Gou J

Subjects
pseudomonas stutzeri, blavim-2, in1998, in1722, tn5563, whole-genome sequencing, bacterial genomics, antibiotic resistance, Infectious and parasitic diseases, RC109-216
Abstract

Shuxiu Liu,1,2 Hao Xu,2 Xiaobing Guo,1 Shuang Li,3 Qian Wang,1,2 Yuan Li,4 Ruishan Liu,1,2 Jianjun Gou1 1Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People’s Republic of China; 2State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, People’s Republic of China; 3Department of Obstetrics and Gynecology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, 450052, People’s Republic of China; 4Department of Nuclear Medicine, The First Affiliated Hospital of ZhengZhou University, Zhengzhou, 450052, People’s Republic of ChinaCorrespondence: Jianjun Gou Tel +86 371 6627 8237Fax +86 371 6691 3569Email jianjung@zzu.edu.cnPurpose: To investigate the genomic and plasmid characteristics of a newly discovered Pseudomonas stutzeri strain with a blaVIM-2-carrying plasmid and novel integron In 1998 isolated from a cerebrospinal fluid specimen in a teaching hospital.Methods: Species identification was performed by MALDI-TOF MS, and blaVIM-2 was identified by PCR and Sanger sequencing. Whole-genome sequencing analysis was conducted using the Illumina NovaSeq 6000 and Oxford Nanopore platforms. Integron detection was performed using INTEGRALL. The phylogenetic tree was constructed by using kSNP3.0. Plasmid characteristics were assessed by S1-pulsed-field gel electrophoresis (S1-PFGE), Southern blotting, conjugation experiments, and whole-genome sequencing analysis. Comparative genomics analysis of the plasmid and genetic context of blaVIM-2 were conducted by using BLAST Ring Image Generator (BRIG) and Easyfig 2.3, respectively.Results: ZDHY95, an MDR strain of P. stutzeri harboring blaVIM-2, was identified. It was sensitive only to amikacin and was resistant to carbapenems, β-lactams, aztreonam, fluoroquinolones, and aminoglycosides. Joint S1-PFGE, Southern blot, conjugation assay, and whole-genome sequencing experiments confirmed that the blaVIM-2 gene was located within class I integron In 1722 of the plasmid and that the surrounding genetic environment was 5ʹCS-aacA4ʹ-30-blaVIM-2-aacA4ʹ-3ʹCS. The novel class I integron In 1998 was detected on the chromosome of P. stutzeri ZDHY95, and the gene cassette array was 5ʹCS-aacA3-aadA13-cmlA8-blaOXA-246-arr3-dfrA27-3ʹCS. Phylogenetic analysis showed that antimicrobial resistance gene-carrying P. stutzeri isolates were divided into two clusters, mainly containing isolates from the USA and Pakistan.Conclusion: A novel blaVIM-2-carrying conjugative plasmid, pZDHY95-VIM-2, was reported for the first time in P. stutzeri, elucidating the genetic environment and transfer mechanism. The gene structure of the novel class I integron In 1998 was also clarified. We explored the phylogenetic relationship of P. stutzeri with drug resistance genes and suggested that Pseudomonas with metallo-β-lactamases (MBLs) in the hospital environment may cause infection in patients with long-term intubation or after interventional surgery.Keywords: Pseudomonas stutzeri, blaVIM-2, In 1998, In 1722, Tn 5563, whole-genome sequencing, bacterial genomics, antibiotic resistance

Published
2021

6. An Asymptotic Analysis of a 2-D Model of Dynamically Active Compartments Coupled by Bulk Diffusion

Author

Gou, J. and Ward, M. J.

Subjects
Nonlinear Sciences - Pattern Formation and Solitons, Mathematics - Analysis of PDEs, Quantitative Biology - Cell Behavior
Abstract

A class of coupled cell-bulk ODE-PDE models is formulated and analyzed in a two-dimensional domain, which is relevant to studying quorum sensing behavior on thin substrates. In this model, spatially segregated dynamically active signaling cells of a common small radius $\epsilon\ll 1$ are coupled through a passive bulk diffusion field. The method of matched asymptotic expansions is used to construct steady-state solutions and to formulate a spectral problem that characterizes the linear stability properties of these solutions, with the aim of predicting whether temporal oscillations can be triggered by the cell-bulk coupling. Phase diagrams in parameter space where such collective oscillations can occur are illustrated for two specific choices of the intracellular kinetics. In the limit of very large bulk diffusion, it is shown that the ODE-PDE system can be approximated by a finite-dimensional dynamical system, which is studied both analytically and numerically. For one illustrative example of the theory it is shown that when the number of cells exceeds some critical number, the bulk diffusion field can trigger oscillations that would otherwise not occur without the coupling. Moreover, for two specific models for the intracellular dynamics, we show that there are rather wide regions in parameter space where these triggered oscillations are synchronous in nature. Unless the bulk diffusivity is asymptotically large, it is shown that a clustered spatial configuration of cells inside the domain leads to larger regions in parameter space where synchronous collective oscillations between the small cells can occur. Finally, the linear stability analysis for these cell-bulk models is shown to be qualitatively rather similar to that of localized spot patterns for activator-inhibitor reaction-diffusion systems in the limit of long-range inhibition and short-range activation., Comment: 36 pages, 17 figures. Due to the ArXiv constraint "The abstract field cannot be longer than 1920 characters", the abstract appearing here is shorter than the one in the manuscript

Published
2015
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7. Synergistic Antitumor Efficacy Mediated by Liposomal Co-Delivery of Polymeric Micelles of Vinorelbine and Cisplatin in Non-Small Cell Lung Cancer

Author

Wang S, Gou J, Wang Y, Tan X, Zhao L, Jin X, and Tang X

Subjects
cisplatin, vinorelbine, co-delivery liposomes, combination therapy, polymeric micelles, non-small cell lung cancer, Medicine (General), R5-920
Abstract

Shuhang Wang,1 Jingxin Gou,2 Yue Wang,1 Xinyi Tan,2 Linxuan Zhao,1 Xiangqun Jin,1 Xing Tang2 1Department of Pharmaceutics, College of Pharmacy Sciences, Jilin University, Changchun, 130021, Jilin, People’s Republic of China; 2Department of Pharmaceutics Science, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of ChinaCorrespondence: Xiangqun JinDepartment of Pharmaceutics, College of Pharmacy Sciences, Jilin University, Changchun, 130021, Jilin, People’s Republic of ChinaTel +86 431 85619252Fax +86 431 85619662Email jinxq@jlu.edu.cnPurpose: Non-small cell lung cancer (NSCLC) is an aggressive tumor with high mortality and poor prognosis. In this study, we designed a liposome encapsulating polymeric micelles (PMs) loaded with vinorelbine (NVB) and cis-diamminedichloroplatinum (II) (cisplatin or CDDP) for the treatment of NSCLC.Materials and Methods: Sodium poly(α-l-glutamic acid)-graft-methoxy-polyethylene glycol (PLG-G-PEG5K) was used to prepare NVB-loaded NVB-PMs and CDDP-loaded CDDP-PMs that were co-encapsulated into liposomes by a reverse evaporation method, yielding NVB and CDDP co-delivery liposomes (CoNP-lips) composed of egg phosphatidyl lipid-80/cholesterol/DPPG/DSPE-mPEG2000 at a molar ratio of 52:32:14:2. The CoNP-lips were characterized in terms of particle size, zeta potential, drug content, encapsulation efficiency, and structural properties. Drug release by the CoNP-lips as well as their stability and cytotoxicity was evaluated in vitro, and their antitumor efficacy was assessed in a mouse xenograft model of Lewis lung carcinoma cell-derived tumors.Results: CoNP-lips had a spherical shape with uniform size distribution; the average particle size was 162.97± 9.06 nm, and the average zeta potential was − 13.02± 0.22 mV. In vitro cytotoxicity analysis and the combination index demonstrated that the CoNP-lips achieved a synergistic cytotoxic effect at an NVB:CDDP weight ratio of 2:1 in an NSCLC cell line. There was sustained release of both drugs from CoNP-lips. The pharmacokinetic analysis showed that CoNP-lips had a higher plasma half-life than NP solution, with 6.52- and 8.03-fold larger areas under the receiver operating characteristic curves of NVB and CDDP. CoNP-lips showed antitumor efficacy in tumor-bearing C57BL/6 mice and drug accumulation in tumors via the enhanced permeability and retention effect.Conclusion: CoNP-lips are a promising formulation for targeted therapy in NSCLC.Keywords: cisplatin, vinorelbine, co-delivery liposomes, combination therapy, polymeric micelles, non-small cell lung cancer

Published
2021

10. Whole Earth Telescope Observations of the subdwarf B star KPD 1930+2752: A rich, short period pulsator in a close binary

Author

Reed, M. D., Harms, S. L., Poindexter, S., Zhou, A. -Y., Eggen, J. R., Morris, M. A., Quint, A. C., McDaniel, S., Baran, A., Dolez, N., Kawaler, S. D., Kurtz, D. W., Moskalik, P., Riddle, R., Zola, S., Ostensen, R. H., Solheim, J. -E., Kepler, S. O., Costa, A. F. M., Provencal, J. L., Mullally, F., Winget, D. W., Vuckovic, M., Crowe, R., Terry, D., Avila, R., Berkey, B., Stewart, S., Bodnarik, J., Bolton, D., Binder, P. -M., Sekiguchi, K., Sullivan, D. J., Kim, S. -L., Chen, W. -P., Chen, C. -W., Lin, H. -C., Jian, X. -J., Wu, H., Gou, J. -P., Liu, Z., Leibowitz, E., Lipkin, Y., Akan, C., Cakirli, O., Janulis, R., Pretorius, R., Ogloza, W., Stachowski, G., Paparo, M., Szabo, R., Csubry, Z., Zsuffa, D., Silvotti, R., Marinoni, S., Bruni, I., Vauclair, G., Chevreton, M., Matthews, J. M., Cameron, C., and Pablo, H.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

KPD 1930+2752 is a short-period pulsating subdwarf B (sdB) star. It is also an ellipsoidal variable with a known binary period just over two hours. The companion is most likely a white dwarf and the total mass of the system is close to the Chandresakhar limit. In this paper we report the results of Whole Earth Telescope (WET) photometric observations during 2003 and a smaller multisite campaign from 2002. From 355 hours of WET data, we detect 68 pulsation frequencies and suggest an additional 13 frequencies within a crowded and complex temporal spectrum between 3065 and 6343 $\mu$Hz (periods between 326 and 157 s). We examine pulsation properties including phase and amplitude stability in an attempt to understand the nature of the pulsation mechanism. We examine a stochastic mechanism by comparing amplitude variations with simulated stochastic data. We also use the binary nature of KPD 1930+2752 for identifying pulsation modes via multiplet structure and a tidally-induced pulsation geometry. Our results indicate a complicated pulsation structure that includes short-period ($\approx 16$ h) amplitude variability, rotationally split modes, tidally-induced modes, and some pulsations which are geometrically limited on the sdB star., Comment: 30 pages, 17 figures, 11 tables. Accepted for publication by MNRAS

Published
2010
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12. An FSV analysis approach to verify the robustness of the triple-correlation analysis theoretical framework.

Author

Wu, RMX, Zhang, Z, Zhang, H, Wang, Y, Shafiabady, N, Yan, W, Gou, J, Gide, E, Zhang, S, Wu, RMX, Zhang, Z, Zhang, H, Wang, Y, Shafiabady, N, Yan, W, Gou, J, Gide, E, and Zhang, S

Abstract

Among all the gas disasters, gas concentration exceeding the threshold limit value (TLV) has been the leading cause of accidents. However, most systems still focus on exploring the methods and framework for avoiding reaching or exceeding TLV of the gas concentration from viewpoints of impacts on geological conditions and coal mining working-face elements. The previous study developed a Trip-Correlation Analysis Theoretical Framework and found strong correlations between gas and gas, gas and temperature, and gas and wind in the gas monitoring system. However, this framework's effectiveness must be examined to determine whether it might be adopted in other coal mine cases. This research aims to explore a proposed verification analysis approach-First-round-Second-round-Verification round (FSV) analysis approach to verify the robustness of the Trip-Correlation Analysis Theoretical Framework for developing a gas warning system. A mixed qualitative and quantitative research methodology is adopted, including a case study and correlational research. The results verify the robustness of the Triple-Correlation Analysis Theoretical Framework. The outcomes imply that this framework is potentially valuable for developing other warning systems. The proposed FSV approach can also be used to explore data patterns insightfully and offer new perspectives to develop warning systems for different industry applications.

Published
2023

13. Using multi-focus group method as an effective tool for eliciting business system requirements: Verified by a case study.

Author

Mucharreira, PR, Wu, RMX, Wang, Y, Shafiabady, N, Zhang, H, Yan, W, Gou, J, Shi, Y, Liu, B, Gide, E, Kang, C, Zhang, Z, Shen, B, Li, X, Fan, J, He, X, Soar, J, Zhao, H, Sun, L, Huo, W, Mucharreira, PR, Wu, RMX, Wang, Y, Shafiabady, N, Zhang, H, Yan, W, Gou, J, Shi, Y, Liu, B, Gide, E, Kang, C, Zhang, Z, Shen, B, Li, X, Fan, J, He, X, Soar, J, Zhao, H, Sun, L, and Huo, W

Abstract

This research aims to explore the multi-focus group method as an effective tool for systematically eliciting business requirements for business information system (BIS) projects. During the COVID-19 crisis, many businesses plan to transform their businesses into digital businesses. Business managers face a critical challenge: they do not know much about detailed system requirements and what they want for digital transformation requirements. Among many approaches used for understanding business requirements, the focus group method has been used to help elicit BIS needs over the past 30 years. However, most focus group studies about research practices mainly focus on a particular disciplinary field, such as social, biomedical, and health research. Limited research reported using the multi-focus group method to elicit business system requirements. There is a need to fill this research gap. A case study is conducted to verify that the multi-focus group method might effectively explore detailed system requirements to cover the Case Study business's needs from transforming the existing systems into a visual warning system. The research outcomes verify that the multi-focus group method might effectively explore the detailed system requirements to cover the business's needs. This research identifies that the multi-focus group method is especially suitable for investigating less well-studied, no previous evidence, or unstudied research topics. As a result, an innovative visual warning system was successfully deployed based on the multi-focus studies for user acceptance testing in the Case Study mine in Feb 2022. The main contribution is that this research verifies the multi-focus group method might be an effective tool for systematically eliciting business requirements. Another contribution is to develop a flowchart for adding to Systems Analysis & Design course in information system education, which may guide BIS students step by step on using the multi-focus group method t

Published
2023

16. Applications of high-resolution total water storage anomalies from self-supervised data assimilation

Author

Gou, J. and Soja, B.

Abstract

Total water storage anomalies (TWSAs) describe the variations of the terrestrial water cycle, which are essential for better understanding our climate system. Recently, we have developed a self-supervised data assimilation algorithm to combine the advantages of the TWSAs obtained from the Gravity Recovery And Climate Experiment (GRACE) satellite mission and the WaterGAP Global Hydrology Model (WGHM) model, resulting in a high-quality TWSA product with a spatial resolution of 0.5 degrees. In this presentation, we discuss the potential applications and contributions of the downscaled TWSAs, from understanding long-term changes in water storage to monitoring short-term climate extremes. Benefiting from the strong performance in retaining the long-term trends, the downscaled TWSAs allow us to study the water changes on a local scale. For example, the significant negative trends in the High Plains aquifer are partially smoothed out in the GRACE TWSAs since the positive trends in the neighbouring cells caused by progress from dry to wet periods average them out. These signals can be better separated from the downscaled TWSAs. In the aspect of short-term variations, we can derive the well-established GRACE-based indices, such as the flooding potential index and drought severity index, using downscaled TWSAs. The high-resolution indices visually agree with the GRACE-derived ones on larger scales while opening the window to monitor extreme environmental events with higher spatial resolution. As a result, hazard monitoring and prevention could be better targeted and more efficiently conducted by different organisations and governments., The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)

Published
2023
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17. Operational 14-day-ahead prediction of Earth's effective angular momentum functions with machine learning

Author

Kiani Shahvandi, M., Schartner, M., Gou, J., and Soja, B.

Abstract

Effective Angular Momentum (EAM) functions of the Earth are connected to the various geophysical processes that perturb the Earth's tensor of inertia, thereby causing excitations that result in variations in Earth's rotation. Therefore, for the analysis of Earth Orientation Parameters (EOP), the determination and prediction of EAM functions are of high importance. The latter would benefit high-accuracy predictions of EOP, an essential task in geodesy for real time applications such as spacecraft navigation. For this reason, the Space Geodesy Group at ETH Zurich uniquely provides 14-day predictions of EAM functions on a daily basis via its Geodetic Prediction Center https://gpc.ethz.ch/EAM. The products cover the domains of the atmosphere, ocean, hydrology, and sea level, including both mass and motion terms. The general approach is based on a variation of Neural ODE, a powerful neural network tool for the prediction of time series of physical origin. A comparison to the results of other institutes reveals that our predictions during the first 6 days are more accurate by 50%. In addition, EAM predictions of days 7 to 14 show a good agreement with observations, thereby enabling us to better predict EOP. We show, for instance, that the 10-day prediction accuracy of length of day is improved on average by 17% by using the improved forecasts of the axial components of EAM., The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)

Published
2023
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21. The Effect of Frequency Transposition on Speech Perception in Adolescents and Young Adults with Profound Hearing Loss

Author

Gou, J., Smith, J., Valero, J., and Rubio, I.

Abstract

This paper reports on a clinical trial evaluating outcomes of a frequency-lowering technique for adolescents and young adults with severe to profound hearing impairment. Outcomes were defined by changes in aided thresholds, speech perception, and acceptance. The participants comprised seven young people aged between 13 and 25 years. They were divided into two groups based on their audiometric configuration. The first group consisted of four young people with pure tone thresholds of less than or equal to 100 dB at 1 kHz. The second group had more profound hearing loss, with pure tone thresholds of greater than 100 dB at 1 kHz. All participants attended the Fundacio Widex Audiologia in Barcelona, a charitable foundation offering intervention and habilitation programmes for hearing-impaired children of all ages. The participants were oral communicators integrated into mainstream high schools and universities. All were experienced hearing aid users with excellent spoken language and no other disability. The hearing aids were fitted using standardized procedures and were worn with the frequency transposition algorithm in the first programme for consistent everyday use. Phoneme and word recognition were assessed after 4, 8, and 12 weeks of use and compared with results for their own superpower hearing aids. Subjective comments from both the participants and their parents were recorded throughout the study. Notable improvements were observed in both sound-field-aided thresholds and speech perception after 12 weeks of use, suggesting that frequency lowering can be efficacious in improving speech perception in severely to profoundly hearing-impaired individuals who are past the critical age for language acquisition. (Contains 2 tables and 6 figures.)

Published
2011
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22. Dosage differences in12-OXOPHYTODIENOATE REDUCTASEgenes modulate wheat primary root growth

Author

Gabay, G., primary, Wang, H., additional, Zhang, J., additional, Moriconi, J. I., additional, Burguener, G. F., additional, Howell, T., additional, Lukaszewski, A., additional, Staskawicz, B., additional, Cho, M.-J., additional, Tanaka, J., additional, Fahima, T., additional, Ke, H., additional, Dehesh, K., additional, Zhang, G.-L., additional, Gou, J.-Y., additional, Hamberg, M., additional, Maria, G. Santa, additional, and Dubcovsky, J., additional

Published
2022
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26. A comparative analysis of the principal component analysis and entropy weight methods to establish the indexing measurement.

Author

Pamucar, D, Wu, RMX, Zhang, Z, Yan, W, Fan, J, Gou, J, Liu, B, Gide, E, Soar, J, Shen, B, Fazal-E-Hasan, S, Liu, Z, Zhang, P, Wang, P, Cui, X, Peng, Z, Wang, Y, Pamucar, D, Wu, RMX, Zhang, Z, Yan, W, Fan, J, Gou, J, Liu, B, Gide, E, Soar, J, Shen, B, Fazal-E-Hasan, S, Liu, Z, Zhang, P, Wang, P, Cui, X, Peng, Z, and Wang, Y

Abstract

BACKGROUND: As the world's largest coal producer, China was accounted for about 46% of global coal production. Among present coal mining risks, methane gas (called gas in this paper) explosion or ignition in an underground mine remains ever-present. Although many techniques have been used, gas accidents associated with the complex elements of underground gassy mines need more robust monitoring or warning systems to identify risks. This paper aimed to determine which single method between the PCA and Entropy methods better establishes a responsive weighted indexing measurement to improve coal mining safety. METHODS: Qualitative and quantitative mixed research methodologies were adopted for this research, including analysis of two case studies, correlation analysis, and comparative analysis. The literature reviewed the most-used multi-criteria decision making (MCDM) methods, including subjective methods and objective methods. The advantages and disadvantages of each MCDM method were briefly discussed. One more round literature review was conducted to search publications between 2017 and 2019 in CNKI. Followed two case studies, correlation analysis and comparative analysis were then conducted. Research ethics was approved by the Shanxi Coking Coal Group Research Committee. RESULTS: The literature searched a total of 25,831publications and found that the PCA method was the predominant method adopted, and the Entropy method was the second most widely adopted method. Two weighting methods were compared using two case studies. For the comparative analysis of Case Study 1, the PCA method appeared to be more responsive than the Entropy. For Case Study 2, the Entropy method is more responsive than the PCA. As a result, both methods were adopted for different cases in the case study mine and finally deployed for user acceptance testing on 5 November 2020. CONCLUSIONS: The findings and suggestions were provided as further scopes for further research. This research indicated tha

Published
2022

30. Reg3g ameliorates Tacrolimus-induced pancreatic β cell dysfunction by restoring mitochondrial function

Author

Zhang Z, Tian C, Ma K, Peng W, Li Q, Xie M, Xiang M, Lu Y, Gou J, Li S, Yang J, and Zhou H

Subjects
stomatognathic diseases, medicine.anatomical_structure, Text mining, business.industry, Cell, Medicine, Pharmacology, business, Function (biology), REG3G, Tacrolimus
Abstract

Background and Purpose: Tacrolimus (Tac) induces pancreatic β cell dysfunction, causing new-onset diabetes mellitus (NODM) after transplantation. Reg3g is a member of the pancreatic regenerative gene family, as reported to improve type 1 diabetes by promoting β cell regeneration. Here, we aim to investigate the role and approach of Reg3g in reversing Tac-induced β cell dysfunction and NODM in mice. Experimental Approach: Circulating REG3A (the human homolog of mouse Reg3g) concentrations of patients treated with Tac after heart transplantation(HT) were detected. The glucose-stimulated insulin secretion (GSIS) and mitochondrial functions, including mitochondria membrane potential (MMP), mitochondria calcium uptake, ATP production, and oxygen consumption rate (OCR), were tested in β cells. Effects of Reg3g on Tac-induced NODM in mice were studied. Key Results: Circulating REG3A levels significantly decreased in NODM patients treated with Tac compared with those without diabetes. Tac down-regulated Reg3g via inhibiting STAT3-mediated transcription activation, while Reg3g protected against Tac-induced apoptosis of β cells. Besides, Reg3g restored GSIS suppressed by Tac in β cells via improving mitochondrial function, including increased MMP, mitochondria calcium uptake, ATP production, and OCR. Mechanically, Reg3g increased accumulation of pSTAT3(Ser727) in mitochondria by activating ERK1/2-STAT3 signaling pathway, leading to restoration of Tac-caused mitochondrial impairment. Moreover, Reg3g overexpression effectively ameliorated Tac-induced NODM in mice. Conclusion and Implications: Reg3g ameliorates Tac-induced pancreatic β cell dysfunction by restoring mitochondrial function via a pSTAT3(Ser727)-dependent way. Our observations identify a novel Reg3g-involved mechanism underlying the augmented incidence of Tac-induced NODM and reveal that Reg3g ameliorates Tac-induced β cell dysfunction.

Published
2021

33. CNRD v1.0: a high-quality natural runoff dataset for hydrological and climate studies in China

Author

Gou, J., Miao, C., Wu, J., Guo, X., Samaniego, Luis, Xiao, M., Gou, J., Miao, C., Wu, J., Guo, X., Samaniego, Luis, and Xiao, M.

Abstract

Reliable, spatiotemporally continuous runoff records are necessary for identifying climate change impacts and planning effective water management strategies. Existing Chinese runoff data to date have been produced from sparse, poor-quality gauge measurements at different time scales. We have developed a new, quality-controlled gridded runoff dataset, the China Natural Runoff Dataset version 1.0 (CNRD v1.0), which provides daily, monthly, and annual 0.25° runoff estimates for the period 1961–2018 over China. CNRD v1.0 was generated using the Variable Infiltration Capacity (VIC) model. A comprehensive parameter uncertainty analysis framework incorporating parameter sensitivity analysis, optimization, and regionalization with 200 natural or near-natural gauge catchments was used to train the VIC model. Overall, the results show well-calibrated parameters for most gauged catchments except arid and semiarid areas, and the skill scores present high values for all catchments. For the pseudo-/test-ungauged catchments, the model parameters estimated by the multiscale parameter regionalization technique offer the best regionalization solution. CNRD v1.0 is the first free public dataset of gridded natural runoff estimated using a comprehensive model parameter uncertainty analysis framework for China. These results indicate that CNRD v1.0 has high potential for application to long-term hydrological and climate studies in China and to improve international runoff databases for global-scale studies.

Published
2021

34. Rayleigh–Taylor and Richtmyer–Meshkov instabilities in the presence of an inclined magnetic field.

Author

Sun, Y. B., Gou, J. N., and Zeng, R. H.

Subjects
*RICHTMYER-Meshkov instability, *MAGNETIC fields, *MAGNETIC field effects, *MAGNETIC flux density, *DISPERSION relations, *RAYLEIGH-Taylor instability
Abstract

A unified and analytical model is developed to study the effects of an inclined magnetic field on magneto-Rayleigh–Taylor (MRT) and magneto-Richtmyer–Meshkov (MRM) instabilities in ideal magnetohydrodynamics. Unlike either a horizontal or a vertical magnetic field is present, the decay modes possess decaying and oscillation behaviors together. The vorticity transportation is analyzed. The dispersion relations are derived, and some interesting phenomena are observed. For a small R that represents the ratio of the magnetic field strength, or equivalently, the inclination θ, the growth rate of MRT instabilities resembles the case when a vertical magnetic field is present. For a large R, the growth rate resembles to the case when a horizontal magnetic field exists. The maximum growth rate becomes strongly dependent on At instead of on R. Furthermore, analytical expression is obtained for the MRM instability by using the impulsive accelerated model. The decaying and oscillating rates of the perturbed amplitude are explicitly related to θ. For two limiting cases, with either the vertical or the horizontal magnetic field existing, our results retrieve previous one of the theoretical analyses and numerical simulations. Generally, the asymptotic amplitude becomes independent of the wave number of the initial perturbation in the MRM instability. These findings regarding magneto-hydrodynamic interfacial instabilities in an inclined magnetic field could provide physical insights for magnetically driven targets and astrophysical observations. This analytical model is easily expanded to investigate the effects of finite thickness of magnetic slab and sheared magnetic field in relevant to high-energy-density physics and to astrophysics. [ABSTRACT FROM AUTHOR]

Published
2022
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37. Staging Procedures Fail to Benefit to the Fertility-preserved Women with Borderline Ovarian Tumors: A Retrospective Analysis of 448 cases

Author

Hu Tw, Ming X, Li N, Gou J, Li L, and Li Z

Subjects
medicine.medical_specialty, Text mining, business.industry, Obstetrics, media_common.quotation_subject, Retrospective analysis, Medicine, Fertility, Borderline ovarian tumors, business, media_common
Abstract

Purpose The study is aimed to evaluate the potential effect of clinicopathologic and surgical factors on the prognosis and fertile outcomes in the patients with borderline ovarian tumors. Patients and Methods We performed a retrospective analysis involving BOT patients who had underwent surgical procedures in West China Second University Hospital from January 2008 to January 2015 . The disease-free survival (DFS) outcomes and potential prognostic factors were evaluated using Kaplan-Meier method and Cox regression analysis, respectively. Furthermore, the fertile outcomes were analyzed using Pearson Χ2 and Fish correlation test. Results A total of 448 patients were included with a median age of 37.1 years and a median follow-up time of 113 months. Forty-two (11.6%) recurrences with the mean recurrence interval 80.2 months and four (0.9%) deaths were observed. One hundred and eighteen (26.3%) patients were underwent staging surgery and the remaining 330 (73.7%) patents underwent unstaged surgery. A total of 233 patients undergoing fertility sparing surgery (FSS) attempted to conceive and 92 (39.48%) of them achieved pregnancy. No statistically significant difference of fertile outcomes were found between staging surgery group or not (P=0.691). In univariate analyse, staging surgery was obviously associated with DFS (HR=2.191 P=0.005), but was not an independent prognostic factor (p=0.600) for DFS on multivariate analysis. The multivariate Cox analysis revealed that advanced FIGO stage (≥stage II), positive ascites\pelvic washings and laparotomy approach were independent prognostic factors for DFS in overall patients, whereas advanced stage (≥stage II), laparotomy approach, cystectomy-included procedure, invasive implants and bilateral tumors were independent prognostic factors for DFS in patients undergoing FSS. In addition, laparoscopy approach had better prognosis than laparotomy in patients of early stage (stage I) with fertility desire. Conclusion Patients with BOT fail to benefit from surgical staging in prognosis and fertile outcomes. Laparoscopy will be recommended to patients of stage I with fertility desire. Patients with fertility desire at advanced stage (≥stage II), invasive implants and bilateral tumors should pay more attention to the risk of recurrence and choose FSS carefully.

Published
2020

42. Numerical Green's function of a point current source in horizontal multilayer soils by utilizing the vector matrix pencil technique

Author

Zou, J., Zeng, R., He, J.L., Gou, J., Gao, Y.Q., and Chen, S.M.

Subjects
Electromagnetism -- Research, Business, Electronics, Electronics and electrical industries
Abstract

Numerical Green's function approach is propose to calculate Green's function of a point current source in arbitrary horizontal multilayer soil. The coefficients of Green function are straightforwardly sampled in an iterative way terms of the simultaneous equation system satisfying the pertinent boundary value problem, then the closed-form expression Green's function for multilayer soil can be given by the vector matrix pencil technology. The approach proposed could be practically applied in grounding problems in an arbitrarily layered soil without needing to derive the analytical expression of Green function. Index Terms--Grounding system, multilayer soil, numeric Green's function, vector matrix pencil method.

Published
2004

47. Verteporfin, a suppressor of YAP–TEAD complex, presents promising antitumor properties on ovarian cancer

Author

Feng J, Gou J, Jia J, Yi T, Cui T, and Li Z

Subjects
ovarian cancer, verteporfin, Hippo pathway, YAP, CCN2, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282
Abstract

Juntao Feng,1 Jinhai Gou,1 Jia Jia,1 Tao Yi,2 Tao Cui,1 Zhengyu Li1,2 1Department of Gynecology and Obstetrics, 2Sichuan Key Laboratory of Gynecologic Oncology, West China Second University Hospital, Sichuan University, Chengdu, People’s Republic of China Abstract: Yes-associated protein (YAP) is a key transcriptional coactivator of Hippo pathway and has been shown to be an oncoprotein in ovarian cancer (OC). Verteporfin (VP), clinically used in photodynamic therapy for neovascular macular degeneration, has been recently proven to be a suppressor of YAP–TEAD complex and has shown potential in anticancer treatment. In this study, we aimed to explore the potential effect of VP in the treatment of OC. Our results showed that VP led to inhibition of proliferation in a time- and dose-dependent manner and to the suppression of migratory and invasive capacities of OC cells. Western blot and real-time polymerase chain reaction demonstrated that VP induced YAP cytoplasmic retention and deregulated inducible YAP and CCNs in OC cells. In vivo, VP exerted a significant effect on tumor growth in OVCAR8 xenograft mice, resulting in tumor nodules with lower average weight and reduced volume of gross ascites. In addition, VP treatment remarkably upregulated cytoplasmic YAP and phosphorylation YAP and downregulated CCN1 and CCN2, but exerted little effect on YAP-upstream components in Hippo pathway. In conclusion, our results suggested that VP may be a promising agent for OC, acting by suppressing YAP–TEAD complex. Keywords: YAP, CCN2, ovarian cancer, verteporfin, Hippo pathway

Published
2016

48. Prognostic significance of TAZ expression in various cancers: a meta-analysis

Author

Feng J, Ren P, Gou J, and Li Z

Subjects
TAZ, meta-analysis, Hippo pathway, overall survival, cancer, prognosis, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282
Abstract

Juntao Feng,1 Pengwei Ren,2 Jinhai Gou,1 Zhengyu Li1,3 1Department of Gynecology and Obstetrics, West China Second University Hospital, 2Department of Evidence-Based Medicine and Clinical Epidemiology, West China Hospital, 3Sichuan Key Laboratory ofGynecologic Oncology, West China Second University Hospital, Sichuan University, Chengdu, People’s Republicof China Background: The overexpression of transcriptional coactivator with PDZ-binding motif (TAZ), a Hippo pathway effector, was detected in a variety of cancers. However, controversies remain in published studies on the prognostic value of TAZ expression in cancer. We performed a meta-analysis to demonstrate the prognostic significance of TAZ in overall survival (OS) and its association with clinicopathologic characteristics. Methods: A systematic literature search was performed by using PubMed, EMBASE, and Web of Science databases for eligible studies investigating the association between TAZ and survival. After extracting data, we used hazard ratio (HR), odds ratio (OR) and 95% confidence intervals (95% CIs) for association evaluation, I2 for heterogeneity across studies, and Egger’s test and Begg’s funnel plot for publication bias assessment. Results: A total of 15 studies including 2,881 patients were analyzed. Pooled results showed that a high TAZ was significantly associated with poor OS (HR =1.82, 95% CI =1.58–2.11; I2=33%; P=0.11). Subgroup analysis indicated significant correlation between TAZ overexpression and OS in patients stratified by ethnicity, sample size, sample source, and staining location. Furthermore, TAZ overexpression was associated with worse OS in hepatocellular carcinoma (HR =2.26, 95% CI =1.43–3.57; P=0.49) and gastrointestinal cancers (HR =2.00, 95% CI=1.54–2.58; P=0.97), but not in non-small-cell lung cancer (HR =1.71, 95% CI =0.93–3.14; P=0.08). TAZ overexpression was also found to be significantly associated with some clinicopathologic characteristics, including TNM stage (OR =2.56, 95% CI =1.60–4.11; P=0.52), tumor differentiation (OR =3.08, 95% CI =1.25–7.63; P=0.01), and lymph node metastasis (OR=2.53, 95% CI =1.81–3.53; P=0.58). Conclusion: TAZ overexpression is not only a predictive factor of poor prognosis but also associated with advanced TNM stage, poor tumor differentiation, and lymph node metastasis. Keywords: Hippo pathway, TAZ, cancer, prognosis, meta-analysis, overall survival

Published
2016

49. Robust discriminative nonnegative dictionary learning for occluded face recognition

Author

Ou, W, Luan, X, Gou, J, Zhou, Q, Xiao, W, Xiong, X, and Zeng, W

Subjects
Computer Science::Computer Vision and Pattern Recognition, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Artificial Intelligence & Image Processing
Abstract

© 2017 Face recognition in real-world video surveillance needs to deal with a lot of challenges including low resolution, illumination variations, pose changes, occlusions and so on. Among them, occlusions are difficult and have not attracted enough attentions. To address this problem, in this paper, we propose a robust discriminative nonnegative dictionary learning method for occluded face recognition, which estimates the occlusions adaptively and selects the features robustly. Instead of modeling the reconstruction errors using a specific distribution, we estimate occlusions adaptively according to the reconstruction errors and learn different weights for different pixels during the iterative processing. To enhance discriminant ability of the dictionary, we constrain the low-dimensional representations of samples from the same class to be as close as possible and select the discriminative features robustly via ℓ2, 1-norm. For the induced non-convex problem, we reformulate it into local convex optimization subproblem via utilizing the half-quadratic technique and propose new update rules. Extensive experiments are implemented on four benchmark datasets, and the experimental results demonstrate the effectiveness and robustness of the proposed method.

Published
2018

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