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2. HLA haplotypes in primary sclerosing cholangitis patients of admixed and non‐European ancestry

Author

Henriksen, E. K. K., Viken, M. K., Wittig, M., Holm, K., Folseraas, T., Mucha, S., Melum, E., Hov, J. R., Lazaridis, K. N., Juran, B. D., Chazouillères, O., Färkkilä, M., Gotthardt, D. N., Invernizzi, P., Carbone, M., Hirschfield, G. M., Rushbrook, S. M., Goode, E., Ponsioen, C. Y., Weersma, R. K., Eksteen, B., Yimam, K. K., Gordon, S. C., Goldberg, D., Yu, L., Bowlus, C. L., Franke, A., Lie, B. A., and Karlsen, T. H.

Published
2017
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5. Management and Outcomes after Multiple Corneal and Solid Organ Transplantations from a Donor Infected with Rabies Virus

Author

Maier, T., Schwarting, A., Mauer, D., Ross, R. S., Martens, A., Kliem, V., Wahl, J., Panning, M., Baumgarte, S., Müller, T., Pfefferle, S., Ebel, H., Schmidt, J., Tenner-Racz, K., Racz, P., Schmid, M., Strüber, M., Wolters, B., Gotthardt, D., Bitz, F., Frisch, L., Pfeiffer, N., Fickenscher, H., Sauer, P., Rupprecht, C. E., Roggendorf, M., Haverich, A., Galle, P., Hoyer, J., and Drosten, C.

Published
2010

8. Variants APOE (rs429358) and TM6SF2 (rs187429064) confer risk to hepatocellular carcinoma

Author

Innes, H, additional, Nischalke, HD, additional, Rosendahl, J, additional, Weiss, KH, additional, Sulk, S, additional, Müller, S, additional, Fischer, J, additional, Casper, M, additional, Gotthardt, D, additional, Lammert, F, additional, Lutz, PL, additional, Semmler, G, additional, Eyer, F, additional, von Felden, J, additional, Link, A, additional, Vogel, A, additional, Guha, IN, additional, Marquardt, J, additional, Trebicka, J, additional, Barnes, E, additional, Valenti, L, additional, Datz, C, additional, Irving, W, additional, JR, Morling, additional, Hamill, V, additional, McLauchlan, J, additional, Benselin, J, additional, Marot, A, additional, Pedergnana, V, additional, Reiberger, T, additional, Ansari, A, additional, Schafmayer, C, additional, Berg, T, additional, Deltenre, P, additional, Stickel, F, additional, Hampe, J, additional, and Buch, S, additional

Published
2021
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18. Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis

Author

Weismueller, T, Strassburg, C, Trivedi, P, Hirschfield, G, Bergquist, A, Said, K, Imam, M, Lazaridis, K, Juran, B, Cheung, A, Lindor, K, Lenzen, H, Manns, M, Ponsioen, C, Beuers, U, Holm, K, Naess, S, Karlsen, T, Schrumpf, E, Boberg, K, Gotthardt, D, Rupp, C, Faerkkilae, M, Jokelainen, K, Marschall, H, Benito De Valle, M, Thorburn, D, Saffioti, F, Weersma, R, Fevery, J, Mueller, T, Chazouillãres, O, Schulze, K, Schramm, C, Almer, S, Pereira, S, Levy, C, Mason, A, Bowlus, C, Floreani, A, Halilbasic, E, Trauner, M, Yimam, K, Milkiewicz, P, Huynh, D, Pares, A, Manser, C, Dalekos, G, Eksteen, B, INVERNIZZI, PIETRO, Berg, C, Kirchner, G, Sarrazin, C, Zimmer, V, Fabris, L, Braun, F, Marzioni, M, Chapman, R, Hansen, B, Hansen, B., AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Gastroenterology and Hepatology, Weismueller, T, Strassburg, C, Trivedi, P, Hirschfield, G, Bergquist, A, Said, K, Imam, M, Lazaridis, K, Juran, B, Cheung, A, Lindor, K, Lenzen, H, Manns, M, Ponsioen, C, Beuers, U, Holm, K, Naess, S, Karlsen, T, Schrumpf, E, Boberg, K, Gotthardt, D, Rupp, C, Faerkkilae, M, Jokelainen, K, Marschall, H, Benito De Valle, M, Thorburn, D, Saffioti, F, Weersma, R, Fevery, J, Mueller, T, Chazouillãres, O, Schulze, K, Schramm, C, Almer, S, Pereira, S, Levy, C, Mason, A, Bowlus, C, Floreani, A, Halilbasic, E, Trauner, M, Yimam, K, Milkiewicz, P, Huynh, D, Pares, A, Manser, C, Dalekos, G, Eksteen, B, Invernizzi, P, Berg, C, Kirchner, G, Sarrazin, C, Zimmer, V, Fabris, L, Braun, F, Marzioni, M, Chapman, R, Hansen, B, Clinicum, Department of Medicine, Gastroenterologian yksikkö, HUS Abdominal Center, Universitat de Barcelona, Gastroenterology & Hepatology, and Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI)

Subjects
Male, Risk Stratification, Time Factors, Cholangitis, POPULATION-BASED COHORT, Ulcerative, Kaplan-Meier Estimate, Gastroenterology, Inflammatory bowel disease, Sclerosing, 0302 clinical medicine, Crohn Disease, Retrospective Studie, MED/12 - GASTROENTEROLOGIA, Risk Factors, Autoimmune Liver Disease, Multivariate Analysi, Crohn's disease, Cholestasis, Incidence, Hazard ratio, Immune-Mediated Liver Disease, Adult, Age Distribution, Australia, Chi-Square Distribution, Cholangitis, Sclerosing, Colitis, Ulcerative, Disease Progression, Europe, Female, Humans, Liver Transplantation, Middle Aged, Multivariate Analysis, North America, Phenotype, Prognosis, Proportional Hazards Models, Retrospective Studies, Risk Assessment, Sex Distribution, Young Adult, Colitis, Ulcerative colitis, Inflamació, CROHNS-DISEASE, 3. Good health, ULCERATIVE-COLITIS, Cholestasi, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Human, medicine.medical_specialty, Time Factor, Prognosi, Lower risk, Article, Primary sclerosing cholangitis, 03 medical and health sciences, Colitis ulcerosa, Internal medicine, medicine, GENOME-WIDE ASSOCIATION, PRIMARY BILIARY-CIRRHOSIS, Inflammation, Hepatology, business.industry, Proportional hazards model, Risk Factor, CLINICAL PRESENTATION, Retrospective cohort study, DOSE URSODEOXYCHOLIC ACID, NATURAL-HISTORY, medicine.disease, digestive system diseases, 3121 General medicine, internal medicine and other clinical medicine, RISK-FACTORS, Proportional Hazards Model, business, SINGLE-CENTER
Abstract

BACKGROUND & AIMS: Primary sclerosing cholangitis (PSC) is an orphan hepatobiliary disorder associated with inflammatory bowel disease (IBD). We aimed to estimate the risk of disease progression based on distinct clinical phenotypes in a large international cohort of patients with PSC. METHODS: We performed a retrospective outcome analysis of patients diagnosed with PSC from 1980 through 2010 at 37 centers in Europe, North America, and Australia. For each patient, we collected data on sex, clinician-reported age at and date of PSC and IBD diagnoses, phenotypes of IBD and PSC, and date and indication of IBD-related surgeries. The primary and secondary endpoints were liver transplantation or death (LTD) and hepatopancreatobiliary malignancy, respectively. Cox proportional hazards models were applied to determine the effects of individual covariates on rates of clinical events, with time-to-event analysis ascertained through Kaplan-Meier estimates. RESULTS: Of the 7121 patients in the cohort, 2616 met the primary endpoint (median time to event of 14.5 years) and 721 developed hepatopancreatobiliary malignancy. The most common malignancy was cholangiocarcinoma (n = 594); patients of advanced age at diagnosis had an increased incidence compared with younger patients (incidence rate: 1.2 per 100 patient-years for patients younger than 20 years old, 6.0 per 100 patient-years for patients 21-30 years old, 9.0 per 100 patient-years for patients 31-40 years old, 14.0 per 100 patient-years for patients 4150 years old, 15.2 per 100 patient-years for patients 51-60 years old, and 21.0 per 100 patient-years for patients older than 60 years). Of all patients with PSC studied, 65.5% were men, 89.8% had classical or large-duct disease, and 70.0% developed IBD at some point. Assessing the development of IBD as a time-dependent covariate, Crohn's disease and no IBD (both vs ulcerative colitis) were associated with a lower risk of LTD (unadjusted hazard ratio [HR], 0.62; P

Published
2017

19. Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis

Author

Buch, S, additional, Stickel, F, additional, Zoller, H, additional, Ryan, E, additional, Sharma, AD, additional, Aigner, E, additional, Griffiths, WJH, additional, Gallati, S, additional, Stewart, S, additional, Lammert, F, additional, Zeissig, S, additional, Berg, T, additional, Zwerina, J, additional, McQuillin, A, additional, Datz, C, additional, Weiss, KH, additional, Gotthardt, D, additional, Morgan, MY, additional, and Hampe, J, additional

Published
2019
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21. Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis

Author

Stickel, F, additional, Lutz, P, additional, Buch, S, additional, Rausch, V, additional, Silva, I, additional, Fischer, J, additional, Nischalke, HD, additional, Rosendahl, J, additional, Krawczyk, M, additional, Casper, M, additional, Zopf, S, additional, Marhenke, S, additional, Lammert, F, additional, Vogel, A, additional, Datz, C, additional, Sharma, R, additional, Eyer, F, additional, Spengler, U, additional, Felden, J, additional, Zeissig, S, additional, Canbay, A, additional, Grove, J, additional, Aithal, G, additional, McQuillin, A, additional, Valenti, L, additional, Weiss, KH, additional, Mueller, S, additional, Morgan, MY, additional, Gotthardt, D, additional, Berg, T, additional, and Hampe, J, additional

Published
2019
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32. Polymorphe Varianten im PNPLA3- und TM6SF2-Gen sind mit dem Hepatozellulären Karzinom bei alkoholischer Leberzirrhose assoziiert

Author

Stickel, F, additional, Buch, S, additional, Fischer, J, additional, Rosendahl, J, additional, Morgan, M, additional, Nischalke, HD, additional, Lammert, F, additional, Casper, M, additional, Zopf, S, additional, Marhenke, S, additional, Vogel, A, additional, Deltenre, P, additional, Eyer, F, additional, Felden, J, additional, Wege, H, additional, Weiss, KH, additional, Gotthardt, D, additional, Berg, T, additional, and Hampe, J, additional

Published
2017
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34. Variants in TM6SF2 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis

Author

Buch, S., primary, Way, M.J., additional, Stickel, F., additional, Ryan, E., additional, Zoller, H., additional, Griffiths, W.J.H., additional, McQuillin, A., additional, Zwerina, J., additional, Ryan, J.D., additional, Gallati, S., additional, Berg, T., additional, Datz, C., additional, Gotthardt, D., additional, Stewart, S., additional, Hampe, J., additional, and Morgan, M.Y., additional

Published
2017
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36. Genetic variation of PNPLA3 and TM6SF2 associate with hepatocellular carcinoma in patients with alcohol-related cirrhosis

Author

Stickel, F., primary, Buch, S., additional, Janet, F., additional, Rosendahl, J., additional, Morgan, M.Y., additional, Nischalke, H.-D., additional, Lammert, F., additional, Casper, M., additional, Zopf, S., additional, Marhenke, S., additional, Vogel, A., additional, Deltenre, P., additional, Eyer, F., additional, Felden, J.V., additional, Gotthardt, D., additional, Datz, C., additional, Zeisig, S., additional, Berg, T., additional, and Hampe, J., additional

Published
2017
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38. Empfehlungen zur antiviralen Therapie der chronischen Hepatitis C bei Patienten auf der Warteliste und nach Transplantation

Author

Zimmermann, T., additional, Beckebaum, S., additional, Berg, C., additional, Berg, T., additional, Braun, F., additional, Eurich, D., additional, Herzer, K., additional, Neumann, U., additional, Rupp, C., additional, Sterneck, M., additional, Strassburg, C., additional, Welker, M.-W., additional, Zachoval, R., additional, Gotthardt, D., additional, Weigand, K., additional, Schmidt, H., additional, Wedemeyer, H., additional, Galle, P., additional, Zeuzem, S., additional, and Sarrazin, C., additional

Published
2016
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40. Validation of the Prognostic Value of Histologic Scoring Systems in Primary Sclerosing Cholangitis; A Multicenter Cohort Study

Author

De Vries, E., primary, Verheij, J., additional, Farkkila, M., additional, Arola, J., additional, Goeppert, B., additional, Schirmacher, P., additional, Gotthardt, D., additional, Trivedi, P., additional, Hirschfield, G., additional, Ytting, H., additional, Vainer, B., additional, Harms, M., additional, van Buuren, H., additional, Biermann, K., additional, Chazouillers, O., additional, Wendum, D., additional, Williamson, K., additional, Chapman, R., additional, Wang, L.M., additional, Hubscher, S., additional, and Ponsioen, C., additional

Published
2016
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41. Autoreactive Iga Antibodies against the Pancreatic Major Glycoprotein 2 are Associated with Primary Sclerosing Cholangitis and Related Biliary Tract Cancer

Author

Jendrek, S.T., primary, Gotthardt, D., additional, Nitzsche, T., additional, Korf, T., additional, Michaels, M.A., additional, Weiss, K.-H., additional, Liaskou, E., additional, Vesterhus, M., additional, Karlsen, T.H., additional, Mindorf, S., additional, Schemmer, P., additional, Bär, F., additional, Schröder, T., additional, Ehlers, M., additional, Hammers, C.M., additional, Komorowski, L., additional, Lehnert, H., additional, Fellermann, K., additional, Derer, S., additional, Hov, J.R., additional, and Sina, C., additional

Published
2016
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45. Biliary strictures and recurrent disease after liver transplantation for primary sclerosing cholangitis - a large, multicenter cohort analysis with long-term follow-up

Author

Teufel, A., Sarrazin, C., Pannicke, N., Kirchner, G., Zimmer, V., Lenzen, Henrike, Schramm, C., Weismüller, T.J., Rust, C., Lammert, F., de Leuw, P., Horn, T., Dechene, Alexander, Sterneck, M., Reiter, F.P., Strassburg, C.P., Herzer, Kerstin, Gotthardt, D., Manns, M.P., Barg-Hock, H., and Spengler, Ulf

Subjects
Medizin
Published
2013

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