97 results on '"Gotte, Matthias"'
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2. Efficient Incorporation and Template‐Dependent Polymerase Inhibition are Major Determinants for the Broad‐Spectrum Antiviral Activity of Remdesivir
3. Respiratory Syncytial Virus Immunoreactivity, Vaccine Development, and Therapeutics
4. HIV-1 reverse transcriptase connection domain mutations: dynamics of emergence and implications for success of combination antiretroviral therapy
5. Should we include connection domain mutations of HIV-1 reverse transcriptase in HIV resistance testing?
6. Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases
7. Application of Molecular Dynamics Simulations to the Design of Nucleotide Inhibitors Binding to Norovirus Polymerase
8. A living WHO guideline on drugs for covid-19
9. Epidemiological and biological evidence for a compensatory effect of connection domain mutation N348I on M184V in HIV-1 reverse transcriptase
10. Non-Nucleoside Inhibitors of HIV Reverse Transcriptase
11. Suppression of an intrinsic strand transfer activity of HIV-1 Tat protein by its second-exon sequences
12. Investigating the 'steric gate' of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by targeted insertion of unnatural amino acids
13. 8-modified-2'-deoxyadenosine analogues induce delayed polymerization arrest during HIV-1 reverse transcription
14. Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H
15. Effects of Nucleotides and Nucleotide Analogue Inhibitors of HIV-1 Reverse Transcriptase in a Ratchet Model of Polymerase Translocation
16. HIV-1 Entry Inhibitor Resistance
17. HIV-1 Resistance to Reverse Transcriptase Inhibitors
18. HIV Drug Resistance in Mothers and Infants Following Use of Antiretrovirals to Prevent Mother-to-Child Transmission
19. HIV-1 Drug Resistance in Pre-exposure Prophylaxis Trials
20. The Ins and Outs of Azole Antifungal Drug Resistance: Molecular Mechanisms of Transport
21. HIV Protease Inhibitor Resistance
22. The Role of Biofilm Matrix in Mediating Antifungal Resistance
23. Azole Resistance in Aspergillus fumigatus: Mechanisms, Route of Resistance Selection, and Clinical Implications
24. Use of Novel Tools to Probe Drug Resistance in Fungi
25. Antiviral Drug Resistance in Herpesviruses
26. Microevolution of Antifungal Drug Resistance
27. Transmission of HIV-1 Drug Resistance
28. Drug Resistance in Leishmania
29. Strategies for Circumventing Bacterial Resistance Mechanisms
30. Antibiotic Resistance and Tolerance in Bacterial Biofilms
31. Drug-Resistant Tuberculosis
32. The Biochemistry of Quinoline Antimalarial Drug Resistance
33. Substrate-Envelope-Guided Design of Drugs with a High Barrier to the Evolution of Resistance
34. The Mechanisms of Resistance to β-Lactam Antibiotics
35. Contribution of APOBEC3-Driven Mutagenesis to HIV Evolution and HIV Drug Resistance
36. Protease Inhibitor Resistance
37. HBV Therapy and the Problem of Drug Resistance
38. Resistance to Cyclophilin Inhibitors
39. Quasispecies and Drug Resistance
40. RT Inhibitors as Microbicides
41. HIV Population Dynamics
42. The RNase H Domain: Structure, Function and Mechanism
43. Role of RNase H Activity in NRTI/NNRTI Drug Resistance
44. HIV Reverse Transcriptase Fidelity, Clade Diversity, and Acquisition of Drug Resistance
45. Conformational Dynamics of Reverse Transcription
46. Targeting RT Translocation
47. APOBECs and Their Role in Proviral DNA Synthesis
48. Targeting Small Molecules and Peptides to the p66-p51 Reverse Transcriptase Interface
49. Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs)
50. Nucleoside RT Inhibitors: Structural and Molecular Biology
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