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19 results on '"Gotlib, Karnit"'

1. Aurora B Kinase Inhibition by AZD1152 Concomitant with Tumor Treating Fields Is Effective in the Treatment of Cultures from Primary and Recurrent Glioblastomas

Author

Krex, Dietmar, primary, Bartmann, Paula, additional, Lachmann, Doris, additional, Hagstotz, Alexander, additional, Jugel, Willi, additional, Schneiderman, Rosa, additional, Gotlib, Karnit, additional, Porat, Yaara, additional, Robel, Katja, additional, Temme, Achim, additional, Giladi, Moshe, additional, and Michen, Susanne, additional

Published
2023
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2. Abstract 1063: Effectiveness of Tumor Treating Fields (TTFields) in combination with sorafenib for treatment of hepatocellular carcinomain vitroandin vivo

Author

Davidi, Shiri, primary, Shteingauz, Anna, additional, Jacobovitch, Sara, additional, Gotlib, Karnit, additional, Tempel-Brami, Catherine, additional, Munster, Mijal, additional, Zeevi, Einav, additional, Dor-On, Eyal, additional, Schneiderman, Rosa S., additional, Voloshin, Tali, additional, Haber, Adi, additional, Giladi, Moshe, additional, Kinzel, Adrian, additional, Weinberg, Uri, additional, and Palti, Yoram, additional

Published
2021
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3. Abstract B14: Immunomodulatory effect of tumor treating fields (TTFields) results in enhanced antitumor efficacy when combined with anti-PD-1 therapy

Author

Voloshin, Tali, primary, Davidi, Shiri, additional, Porat, Yaara, additional, Shteingauz, Anna, additional, Munster, Mijal, additional, Kaynan, Noa, additional, Schneiderman, Rosa S, additional, Brami, Catherine Tempel, additional, Alon, Yaniv, additional, Zeevi, Einav, additional, Gotlib, Karnit, additional, Blat, Roni, additional, Cahal, Shay, additional, Itzhaki, Aviran, additional, Giladi, Moshe, additional, Kirson, Eilon D., additional, Weinberg, Uri, additional, Kinzel, Adrian, additional, and Palti, Yoram, additional

Published
2020
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4. In vitro and in vivo efficacy and safety of tumor treating fields (TTFields) and sorafenib combination in hepatocellular carcinoma.

Author

Davidi, Shiri, primary, Tempel-Brami, Catherine, additional, Munster, Mijal, additional, Gotlib, Karnit, additional, Zeevi, Einav, additional, Schneiderman, Rosa S, additional, Voloshin, Tali, additional, Giladi, Moshe, additional, Kinzel, Adrian, additional, Kirson, Eilon D., additional, Weinberg, Uri, additional, and Palti, Yoram, additional

Published
2020
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5. Tumor treating fields (TTFields; 150 kHz) and FOLFOX combination treatment effects on gastric cancer in vitro.

Author

Zeevi, Einav, primary, Gotlib, Karnit, additional, Schneiderman, Rosa S, additional, Munster, Mijal, additional, Porat, Yaara, additional, Voloshin, Tali, additional, Davidi, Shiri, additional, Shteingauz, Anna, additional, Kaynan, Noa, additional, Giladi, Moshe, additional, Kirson, Eilon D., additional, Weinberg, Uri, additional, Kinzel, Adrian, additional, and Palti, Yoram, additional

Published
2020
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6. Immunomodulatory effects of tumor treating fields (TTFields) on colon cancer models.

Author

Voloshin, Tali, primary, Kaynan, Noa, additional, Davidi, Shiri, additional, Porat, Yaara, additional, Shteingauz, Anna, additional, Munster, Mijal, additional, Schneiderman, Rosa S, additional, Tempel-Brami, Catherine, additional, Zeevi, Einav, additional, Gotlib, Karnit, additional, Cahal, Shay, additional, Giladi, Moshe, additional, Kirson, Eilon D., additional, Weinberg, Uri, additional, Kinzel, Adrian, additional, and Palti, Yoram, additional

Published
2020
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8. Abstract 303: The efficacy of the combined treatment of 150 kHz Tumor Treating Fields (TTFields) and FOLFOX in gastric cancer in vitro

Author

Voloshin, Tali, primary, Zeevi, Einav, additional, Gotlib, Karnit, additional, Schneiderman, Rosa S., additional, Munster, Mijal, additional, Porat, Yaara, additional, Davidi, Shiri, additional, Shteingauz, Anna, additional, Kaynan, Noa, additional, Giladi, Moshe, additional, Kirson, Eilon D., additional, Weinberg, Uri, additional, Kinzel, Adrian, additional, and Palti, Yoram, additional

Published
2019
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9. Abstract 3961: Alternating electric fields (TTFields) induce immunogenic cell death resulting in enhanced antitumor efficacy when combined with anti-PD-1 therapy

Author

Voloshin, Tali, primary, Kaynan, Noa, additional, Davidi, Shiri, additional, Porat, Yaara, additional, Shteingauz, Anna, additional, Munster, Mijal, additional, Schneiderman, Rosa S., additional, Brami, Catherine Tempel, additional, Zeevi, Einav, additional, Gotlib, Karnit, additional, Cahal, Shay, additional, Itzhaki, Aviran, additional, Giladi, Moshe, additional, Kirson, Eilon D., additional, Weinberg, Uri, additional, Kinzel, Adrian, additional, and Palti, Yoram, additional

Published
2019
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11. Abstract 307: The combined treatment of 150 kHz Tumor Treating Fields (TTFields) and Cisplatin or Pemetrexed inhibit mesothelioma cells in vitro

Author

Munster, Mijal, primary, Schneiderman, Rosa, additional, Porat, Yaara, additional, Voloshin, Tali, additional, Davidi, Shiri, additional, Shteingauz, Anna, additional, Kaynan, Noa, additional, Zeevi, Einav, additional, Gotlib, Karnit, additional, Giladi, Moshe, additional, Kirson, Eilon, additional, Weinberg, Uri, additional, Kinzel, Adrian, additional, and Palti, Yoram, additional

Published
2019
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12. Abstract 306: The efficacy of the combined treatment of 150 KHz tumor treating fields (TTFields) and Sorafenib in hepatocellular carcinoma in vitro and in vivo

Author

Voloshin, Tali, primary, Davidi, Shiri, additional, Tempel-Brami, Catherine, additional, Munster, Mijal, additional, Gotlib, Karnit, additional, Zeevi, Einav, additional, Schneiderman, Rosa S., additional, Giladi, Moshe, additional, Kinzel, Adrian, additional, Kirson, Eilon D., additional, Weinberg, Uri, additional, and Palti, Yoram, additional

Published
2019
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13. The combined treatment of 150 kHz tumor treating fields (TTFields) and sorafenib inhibits hepatocellular carcinoma in vitro and in vivo.

Author

Weinberg, Uri, primary, Davidi, Shiri, additional, Tempel- Brami, Catherine, additional, Munster, Mijal, additional, Gotlib, Karnit, additional, Zeevi, Einav, additional, Schneiderman, Rosa S., additional, Voloshin, Tali, additional, Giladi, Moshe, additional, Kinzel, Adrian, additional, Kirson, Eilon David, additional, and Palti, Yoram, additional

Published
2019
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14. The combined treatment of 150 kHz tumor treating fields (TTFields) and cisplatin or pemetrexed inhibits mesothelioma cells in vitro and in vivo.

Author

Weinberg, Uri, primary, Munster, Mijal, additional, Gotlib, Karnit, additional, Schneiderman, Rosa S., additional, Porat, Yaara, additional, Voloshin, Tali, additional, Davidi, Shiri, additional, Shteingauz, Anna, additional, Kaynan, Noa, additional, Zeevi, Einav, additional, Giladi, Moshe, additional, Kirson, Eilon David, additional, Kinzel, Adrian, additional, and Palti, Yoram, additional

Published
2019
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15. In vitro and in vivo efficacy of the combined treatment of 150 khz tumor treating fields (TTFields) and sorafenib in hepatocellular carcinoma.

Author

Weinberg, Uri, primary, Davidi, Shiri, additional, Gotlib, Karnit, additional, Zeevi, Einav, additional, Tempel- Brami, Catherine, additional, Schneiderman, Rosa S., additional, Voloshin, Tali, additional, Giladi, Moshe, additional, Kinzel, Adrian, additional, Kirson, Eilon David, additional, and Palti, Yoram, additional

Published
2019
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16. CBMT-29. INDUCTION OF AUTOPHAGY FOLLOWING TTFIELDS APPLICATION SERVES AS A SURVIVAL MECHANISM MEDIATED BY AMPK ACTIVATION

Author

Shteingauz, Anna, Porat, Yaara, Voloshin, Tali, Schneiderman, Rosa S, Munster, Mijal, Zeevi, Einav, Kaynan, Noa, Gotlib, Karnit, Giladi, Moshe, Kirson, Eilon, Weinberg, Uri, Kinzel, Adrian, and Plati, Yoram

Subjects
Abstracts, Cancer Research, Oncology, Neurology (clinical)
Abstract

Tumor treating fields (TTFields) are an approved treatment modality for patients with glioblastoma. Previous studies have shown that TTFields lead to increased cellular granularity, which is often associated with autophagy. In this study, we evaluated the effect of TTFields on the induction of autophagy in glioma cells. Cells were treated with TTFields using the inovitro system. Autophagy was monitored by quantifying levels of lipidated Microtubule Associated Protein Light Chain 3 (LC3-II) using immunoblotting and immunofluorescence microscopy. Transmission Electron Microscopy (TEM) was used to visualize autophagosome-like structures. Western blot analysis was utilized to evaluate autophagy regulatory activity of mTOR through p70 S6 kinase1 and AMPK and its down-stream target ULK-1. siRNAs was used to deplete siAMPK from U87-MG cells. To evaluate involvement of autophagy in cell fate after TTFields treatment, we produced glioma cell lines depleted from ATG7 by shATG7 infection. Significant elevation in LC3-II levels was observed in TTFields-treated cells using fluorescence microscopy; punctate distribution of LC3-II was observed. TEM micrographs demonstrated the presence of autophagy typical, autophagosome-like structures following TTFields treatment. Evidence of increased autophagic flux following TTFields treatment was detected using immunoblotting analysis in the presence of CQ. Western blot analysis of cells after TTFields treatment revealed the stimulation of AMPK signaling as well as activation of p70. Depletion of AMPK from U87-MG cells resulted in reduction of autophagy and enhancement of TTFields cytotoxicity. ER stress in treated cells was evident by immunoblotting, showing increased levels of ER stress marker GRP78. The combination of TTFields with CQ resulted in a significant dose-dependent reduction of cell growth compared with TTFields treatment alone. Cells with ATG7 depletion showed similar results. Combined, these results suggest that cells upregulate autophagy in response to ER stress induced by TTFields application and that AMPK may serve as a key regulator of this process.

Published
2018

17. AMPK-dependent autophagy upregulation serves as a survival mechanism in response to Tumor Treating Fields (TTFields)

Author

Shteingauz, Anna, primary, Porat, Yaara, additional, Voloshin, Tali, additional, Schneiderman, Rosa S., additional, Munster, Mijal, additional, Zeevi, Einav, additional, Kaynan, Noa, additional, Gotlib, Karnit, additional, Giladi, Moshe, additional, Kirson, Eilon D., additional, Weinberg, Uri, additional, Kinzel, Adrian, additional, and Palti, Yoram, additional

Published
2018
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