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279 results on '"Gotlib, Jason R."'

1. Longitudinal study of 2 patients with cyclic thrombocytopenia, STAT3 and MPL mutations

Author

Zhang, Haiyu, Chien, May, Hou, Yu, Shomali, William, Brar, Rondeep S., Ho, Chandler, Han, Panpan, Xu, Danfei, Zhang, Bing M., Guo, Xiangqian, Tolentino, Lorna L., Wu, Nancy C., Tsai, Albert G., Jin, Jing, Witteles, Wesley H., Chen, Zhenping, Abidi, Parveen, Jangam, Diwash, Krieger, Madison S., Craig, Morgan, Bussel, James B., Gotlib, Jason R., and Zehnder, James L.

Published
2023
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2. Genomic landscape of neutrophilic leukemias of ambiguous diagnosis

Author

Zhang, Haijiao, Wilmot, Beth, Bottomly, Daniel, Dao, Kim-Hien T., Stevens, Emily, Eide, Christopher A., Khanna, Vishesh, Rofelty, Angela, Savage, Samantha, Reister Schultz, Anna, Long, Nicola, White, Libbey, Carlos, Amy, Henson, Rachel, Lin, Chenwei, Searles, Robert, Collins, Robert H., DeAngelo, Daniel J., Deininger, Michael W., Dunn, Tamara, Hein, Than, Luskin, Marlise R., Medeiros, Bruno C., Oh, Stephen T., Pollyea, Daniel A., Steensma, David P., Stone, Richard M., Druker, Brian J., McWeeney, Shannon K., Maxson, Julia E., Gotlib, Jason R., and Tyner, Jeffrey W.

Published
2019
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3. Impact of somatic and germline mutations on the outcome of systemic mastocytosis

Author

Muñoz-González, Javier I., Jara-Acevedo, María, Alvarez-Twose, Iván, Merker, Jason D., Teodosio, Cristina, Hou, Yanli, Henriques, Ana, Roskin, Krishna M., Sanchez-Muñoz, Laura, Tsai, Albert G., Caldas, Carolina, Matito, Almudena, Sánchez-Gallego, J. Ignacio, Mayado, Andrea, Dasilva-Freire, Noelia, Gotlib, Jason R., Escribano, Luis, Orfao, Alberto, and García-Montero, Andrés C.

Published
2018
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5. Supplementary Figures from MYC Regulates the HIF2α Stemness Pathway via Nanog and Sox2 to Maintain Self-Renewal in Cancer Stem Cells versus Non-Stem Cancer Cells

Author

Das, Bikul, primary, Pal, Bidisha, primary, Bhuyan, Rashmi, primary, Li, Hong, primary, Sarma, Anupam, primary, Gayan, Sukanya, primary, Talukdar, Joyeeta, primary, Sandhya, Sorra, primary, Bhuyan, Seema, primary, Gogoi, Gayatri, primary, Gouw, Arvin M., primary, Baishya, Debabrat, primary, Gotlib, Jason R., primary, Kataki, Amal C., primary, and Felsher, Dean W., primary

Published
2023
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6. Data from MYC Regulates the HIF2α Stemness Pathway via Nanog and Sox2 to Maintain Self-Renewal in Cancer Stem Cells versus Non-Stem Cancer Cells

Author

Das, Bikul, primary, Pal, Bidisha, primary, Bhuyan, Rashmi, primary, Li, Hong, primary, Sarma, Anupam, primary, Gayan, Sukanya, primary, Talukdar, Joyeeta, primary, Sandhya, Sorra, primary, Bhuyan, Seema, primary, Gogoi, Gayatri, primary, Gouw, Arvin M., primary, Baishya, Debabrat, primary, Gotlib, Jason R., primary, Kataki, Amal C., primary, and Felsher, Dean W., primary

Published
2023
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7. Supplementary Methods from MYC Regulates the HIF2α Stemness Pathway via Nanog and Sox2 to Maintain Self-Renewal in Cancer Stem Cells versus Non-Stem Cancer Cells

Author

Das, Bikul, primary, Pal, Bidisha, primary, Bhuyan, Rashmi, primary, Li, Hong, primary, Sarma, Anupam, primary, Gayan, Sukanya, primary, Talukdar, Joyeeta, primary, Sandhya, Sorra, primary, Bhuyan, Seema, primary, Gogoi, Gayatri, primary, Gouw, Arvin M., primary, Baishya, Debabrat, primary, Gotlib, Jason R., primary, Kataki, Amal C., primary, and Felsher, Dean W., primary

Published
2023
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8. Supplementary Table 4 from Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening

Author

Tyner, Jeffrey W., primary, Yang, Wayne F., primary, Bankhead, Armand, primary, Fan, Guang, primary, Fletcher, Luke B., primary, Bryant, Jade, primary, Glover, Jason M., primary, Chang, Bill H., primary, Spurgeon, Stephen E., primary, Fleming, William H., primary, Kovacsovics, Tibor, primary, Gotlib, Jason R., primary, Oh, Stephen T., primary, Deininger, Michael W., primary, Zwaan, Christian Michel, primary, Den Boer, Monique L., primary, van den Heuvel-Eibrink, Marry M., primary, O'Hare, Thomas, primary, Druker, Brian J., primary, and Loriaux, Marc M., primary

Published
2023
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9. Supplementary Table 3 from Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening

Author

Tyner, Jeffrey W., primary, Yang, Wayne F., primary, Bankhead, Armand, primary, Fan, Guang, primary, Fletcher, Luke B., primary, Bryant, Jade, primary, Glover, Jason M., primary, Chang, Bill H., primary, Spurgeon, Stephen E., primary, Fleming, William H., primary, Kovacsovics, Tibor, primary, Gotlib, Jason R., primary, Oh, Stephen T., primary, Deininger, Michael W., primary, Zwaan, Christian Michel, primary, Den Boer, Monique L., primary, van den Heuvel-Eibrink, Marry M., primary, O'Hare, Thomas, primary, Druker, Brian J., primary, and Loriaux, Marc M., primary

Published
2023
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10. Supplementary Table 5 from Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening

Author

Tyner, Jeffrey W., primary, Yang, Wayne F., primary, Bankhead, Armand, primary, Fan, Guang, primary, Fletcher, Luke B., primary, Bryant, Jade, primary, Glover, Jason M., primary, Chang, Bill H., primary, Spurgeon, Stephen E., primary, Fleming, William H., primary, Kovacsovics, Tibor, primary, Gotlib, Jason R., primary, Oh, Stephen T., primary, Deininger, Michael W., primary, Zwaan, Christian Michel, primary, Den Boer, Monique L., primary, van den Heuvel-Eibrink, Marry M., primary, O'Hare, Thomas, primary, Druker, Brian J., primary, and Loriaux, Marc M., primary

Published
2023
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11. Supplementary Legends for Tables 1-4 and Figures 1-7 from Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening

Author

Tyner, Jeffrey W., primary, Yang, Wayne F., primary, Bankhead, Armand, primary, Fan, Guang, primary, Fletcher, Luke B., primary, Bryant, Jade, primary, Glover, Jason M., primary, Chang, Bill H., primary, Spurgeon, Stephen E., primary, Fleming, William H., primary, Kovacsovics, Tibor, primary, Gotlib, Jason R., primary, Oh, Stephen T., primary, Deininger, Michael W., primary, Zwaan, Christian Michel, primary, Den Boer, Monique L., primary, van den Heuvel-Eibrink, Marry M., primary, O'Hare, Thomas, primary, Druker, Brian J., primary, and Loriaux, Marc M., primary

Published
2023
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12. Supplementary Table 2 from Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening

Author

Tyner, Jeffrey W., primary, Yang, Wayne F., primary, Bankhead, Armand, primary, Fan, Guang, primary, Fletcher, Luke B., primary, Bryant, Jade, primary, Glover, Jason M., primary, Chang, Bill H., primary, Spurgeon, Stephen E., primary, Fleming, William H., primary, Kovacsovics, Tibor, primary, Gotlib, Jason R., primary, Oh, Stephen T., primary, Deininger, Michael W., primary, Zwaan, Christian Michel, primary, Den Boer, Monique L., primary, van den Heuvel-Eibrink, Marry M., primary, O'Hare, Thomas, primary, Druker, Brian J., primary, and Loriaux, Marc M., primary

Published
2023
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13. Supplementary Figures 1-4 from Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening

Author

Tyner, Jeffrey W., primary, Yang, Wayne F., primary, Bankhead, Armand, primary, Fan, Guang, primary, Fletcher, Luke B., primary, Bryant, Jade, primary, Glover, Jason M., primary, Chang, Bill H., primary, Spurgeon, Stephen E., primary, Fleming, William H., primary, Kovacsovics, Tibor, primary, Gotlib, Jason R., primary, Oh, Stephen T., primary, Deininger, Michael W., primary, Zwaan, Christian Michel, primary, Den Boer, Monique L., primary, van den Heuvel-Eibrink, Marry M., primary, O'Hare, Thomas, primary, Druker, Brian J., primary, and Loriaux, Marc M., primary

Published
2023
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14. Supplementary Table 6 from Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening

Author

Tyner, Jeffrey W., primary, Yang, Wayne F., primary, Bankhead, Armand, primary, Fan, Guang, primary, Fletcher, Luke B., primary, Bryant, Jade, primary, Glover, Jason M., primary, Chang, Bill H., primary, Spurgeon, Stephen E., primary, Fleming, William H., primary, Kovacsovics, Tibor, primary, Gotlib, Jason R., primary, Oh, Stephen T., primary, Deininger, Michael W., primary, Zwaan, Christian Michel, primary, Den Boer, Monique L., primary, van den Heuvel-Eibrink, Marry M., primary, O'Hare, Thomas, primary, Druker, Brian J., primary, and Loriaux, Marc M., primary

Published
2023
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15. Supplementary Table 7 from Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening

Author

Tyner, Jeffrey W., primary, Yang, Wayne F., primary, Bankhead, Armand, primary, Fan, Guang, primary, Fletcher, Luke B., primary, Bryant, Jade, primary, Glover, Jason M., primary, Chang, Bill H., primary, Spurgeon, Stephen E., primary, Fleming, William H., primary, Kovacsovics, Tibor, primary, Gotlib, Jason R., primary, Oh, Stephen T., primary, Deininger, Michael W., primary, Zwaan, Christian Michel, primary, Den Boer, Monique L., primary, van den Heuvel-Eibrink, Marry M., primary, O'Hare, Thomas, primary, Druker, Brian J., primary, and Loriaux, Marc M., primary

Published
2023
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16. Supplementary Table 1 from Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening

Author

Tyner, Jeffrey W., primary, Yang, Wayne F., primary, Bankhead, Armand, primary, Fan, Guang, primary, Fletcher, Luke B., primary, Bryant, Jade, primary, Glover, Jason M., primary, Chang, Bill H., primary, Spurgeon, Stephen E., primary, Fleming, William H., primary, Kovacsovics, Tibor, primary, Gotlib, Jason R., primary, Oh, Stephen T., primary, Deininger, Michael W., primary, Zwaan, Christian Michel, primary, Den Boer, Monique L., primary, van den Heuvel-Eibrink, Marry M., primary, O'Hare, Thomas, primary, Druker, Brian J., primary, and Loriaux, Marc M., primary

Published
2023
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17. Sweave Document from Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening

Author

Tyner, Jeffrey W., primary, Yang, Wayne F., primary, Bankhead, Armand, primary, Fan, Guang, primary, Fletcher, Luke B., primary, Bryant, Jade, primary, Glover, Jason M., primary, Chang, Bill H., primary, Spurgeon, Stephen E., primary, Fleming, William H., primary, Kovacsovics, Tibor, primary, Gotlib, Jason R., primary, Oh, Stephen T., primary, Deininger, Michael W., primary, Zwaan, Christian Michel, primary, Den Boer, Monique L., primary, van den Heuvel-Eibrink, Marry M., primary, O'Hare, Thomas, primary, Druker, Brian J., primary, and Loriaux, Marc M., primary

Published
2023
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18. Data from Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening

Author

Tyner, Jeffrey W., primary, Yang, Wayne F., primary, Bankhead, Armand, primary, Fan, Guang, primary, Fletcher, Luke B., primary, Bryant, Jade, primary, Glover, Jason M., primary, Chang, Bill H., primary, Spurgeon, Stephen E., primary, Fleming, William H., primary, Kovacsovics, Tibor, primary, Gotlib, Jason R., primary, Oh, Stephen T., primary, Deininger, Michael W., primary, Zwaan, Christian Michel, primary, Den Boer, Monique L., primary, van den Heuvel-Eibrink, Marry M., primary, O'Hare, Thomas, primary, Druker, Brian J., primary, and Loriaux, Marc M., primary

Published
2023
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21. Outcomes for Myelofibrosis Patients Following Myeloablative Allogeneic Stem Cell Transplantation Using the Orca-T Graft from HLA-Matched Related and Unrelated Donors

Author

Gandhi, Arpita, primary, Moroz, Anna, additional, Muffly, Lori, additional, Shiraz, Parveen, additional, Schachter, Levanto, additional, Fernhoff, Nathaniel, additional, McClellan, James Scott, additional, Negrin, Robert S., additional, Gotlib, Jason R, additional, and Meyer, Everett H., additional

Published
2022
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24. Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens

Author

Fan, Alice C., Deb-Basu, Debabrita, Orban, Mathias W., Gotlib, Jason R., Natkunam, Yasodha, O'Neill, Roger, Padua, Rose-Ann, Xu, Liwen, Taketa, Daryl, Shirer, Amy E., Beer, Shelly, Yee, Ada X., Voehringer, David W., and Felsher, Dean W.

Subjects
Cellular signal transduction -- Genetic aspects, Cellular signal transduction -- Research, Chronic myeloid leukemia -- Genetic aspects, Chronic myeloid leukemia -- Drug therapy, Chronic myeloid leukemia -- Research, Lymphomas -- Drug therapy, Lymphomas -- Genetic aspects, Lymphomas -- Research, Tumor proteins -- Physiological aspects, Tumor proteins -- Genetic aspects, Tumor proteins -- Research
Abstract

Current methods of protein detection are insensitive to detecting subtle changes in oncoprotein activation that underlie key cancer signaling processes. The requirement for large numbers of cells precludes serial tumor sampling for assessing a response to therapeutics. Therefore, we have developed a nanofluidic proteomic immunoassay (NIA) to quantify total and low-abundance protein isoforms in nanoliter volumes. Our method can quantify amounts of MYC oncoprotein and B cell lymphoma protein-2 (BCL2) in Burkitt's and follicular lymphoma; identify changes in activation of extracellular signal-related kinases-1 (ERK1) and ERK2, mitogen-activated kinase-1 (MEK), signal transducer and activator of transcription protein-3 (STAT3) and STAT5, c-Jun N-terminal kinase (JNK) and caspase-3 in imatinib-treated chronic myelogeneous leukemia (CML) cells; measure an unanticipated change in the phosphorylation of an ERK2 isomer in individuals with CML who responded to imatinib; and detect a decrease in STAT3 and STAT5 phosphorylation in individuals with lymphoma who were treated with atorvastatin. Therefore, we have described a new and highly sensitive method for determining oncoprotein expression and phosphorylation in clinical specimens for the development of new therapeutics for cancer., Cancer is frequently associated with the abnormal expression and phosphorylation of oncogenes (1-4). Specific hematopoietic tumors are frequently characterized by the discrete activation of specific oncogenes such as MYC (5-7), [...]

Published
2009

25. Abstract CT216: A Phase 1/2 Study of INCB000928 as Monotherapy or in Combination with Ruxolitinib in Patients with Anemia Due to Myelofibrosis (INCB 00928-104)

Author

Oh, Stephen T., primary, Kiladjian, Jean-Jacques, additional, Palandri, Francesca, additional, Gotlib, Jason R., additional, Mohan, Sanjay, additional, Ali, Haris, additional, Asatiani, Ekatherine, additional, Seguy, Francis, additional, Zhou, Feng, additional, and Verstovsek, Srdan, additional

Published
2021
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26. Longitudinal study of 2 patients with cyclic thrombocytopenia, STAT3and MPLmutations

Author

Zhang, Haiyu, Chien, May, Hou, Yu, Shomali, William, Brar, Rondeep S., Ho, Chandler, Han, Panpan, Xu, Danfei, Zhang, Bing M., Guo, Xiangqian, Tolentino, Lorna L., Wu, Nancy C., Tsai, Albert G., Jin, Jing, Witteles, Wesley H., Chen, Zhenping, Abidi, Parveen, Jangam, Diwash, Krieger, Madison S., Craig, Morgan, Bussel, James B., Gotlib, Jason R., and Zehnder, James L.

Abstract

•Both patients showed sequential exaggerated TPO, platelet gene, and platelet count cycling, as well as trilineage gene fluctuations.•Both had somatic GOF STAT3mutations and clonal T cells; 1 had a novel germline LOF MPLmutation correlating with cycling parameters.

Published
2023
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29. A Phase 2 Study of Luspatercept in Patients with Myelofibrosis-Associated Anemia

Author

Gerds, Aaron T., primary, Vannucchi, Alessandro M., primary, Passamonti, Francesco, primary, Kremyanskaya, Marina, primary, Gotlib, Jason R., primary, Palmer, Jeanne M., primary, McCaul, Kelly, primary, Ribrag, Vincent, primary, Mead, Adam J., primary, Harrison, Claire N, primary, Mesa, Ruben A, primary, Kiladjian, Jean-Jacques, primary, Barosi, Giovanni, primary, Gale, Robert Peter, primary, Laadem, Abderrahmane, primary, Pariseau, Joseph, primary, Gerike, Torsten, primary, Zhang, Jennie, primary, Linde, Peter G., primary, Reynolds, Joseph G., primary, and Verstovsek, Srdan, primary

Published
2019
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31. MYC Regulates the HIF2α Stemness Pathway via Nanog and Sox2 to Maintain Self-Renewal in Cancer Stem Cells versus Non-Stem Cancer Cells

Author

Das, Bikul, primary, Pal, Bidisha, additional, Bhuyan, Rashmi, additional, Li, Hong, additional, Sarma, Anupam, additional, Gayan, Sukanya, additional, Talukdar, Joyeeta, additional, Sandhya, Sorra, additional, Bhuyan, Seema, additional, Gogoi, Gayatri, additional, Gouw, Arvin M., additional, Baishya, Debabrat, additional, Gotlib, Jason R., additional, Kataki, Amal C., additional, and Felsher, Dean W., additional

Published
2019
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33. Comparison of the Transcriptomic Signature of Pediatric Vs. Adult CML and Normal Bone Marrow Stem Cells

Author

Chae, Hee-Don, primary, Murphy, Lara C., additional, Donato, Michele, additional, Lee, Alex G., additional, Sweet-Cordero, E. Alejandro, additional, Abidi, Parveen, additional, Bittencourt, Henrique, additional, Lacayo, Norman J., additional, Dahl, Gary Van Houten, additional, Aftandilian, Catherine, additional, Davis, Kara L., additional, Huang, Min, additional, Sumarsono, Nathan, additional, Redell, Michele, additional, Fu, Cecilia H., additional, Chen, I-Ming L., additional, Alonzo, Todd A, additional, Eklund, Elizabeth A., additional, Gotlib, Jason R., additional, Khatri, Purvesh, additional, Hijiya, Nobuko, additional, and Sakamoto, Kathleen M., additional

Published
2018
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34. Interim Results from Fight-203, a Phase 2, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Pemigatinib (INCB054828) in Patients with Myeloid/Lymphoid Neoplasms with Rearrangement of Fibroblast Growth Factor Receptor 1 (FGFR1)

Author

Verstovsek, Srdan, primary, Vannucchi, Alessandro M., additional, Rambaldi, Alessandro, additional, Gotlib, Jason R., additional, Mead, Adam J., additional, Hochhaus, Andreas, additional, Kiladjian, Jean-Jacques, additional, Hernandez Boluda, Juan Carlos, additional, Asatiani, Ekaterine, additional, Lihou, Christine, additional, Zhen, Huiling, additional, and Reiter, Andreas, additional

Published
2018
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35. Avapritinib, a Potent and Selective Inhibitor of KIT D816V, Improves Symptoms of Advanced Systemic Mastocytosis (AdvSM): Analyses of Patient Reported Outcomes (PROs) from the Phase 1 (EXPLORER) Study Using the (AdvSM) Symptom Assessment Form (AdvSM-SAF), a New PRO Questionnaire for (AdvSM)

Author

Gotlib, Jason R., primary, Radia, Deepti, additional, DeAngelo, Daniel J., additional, Bose, Prithviraj, additional, Drummond, Mark W, additional, Hexner, Elizabeth O., additional, Robinson, William A, additional, Conlan, Maureen G., additional, Oren, Ronny G., additional, Shi, Hongliang, additional, and Deininger, Michael W., additional

Published
2018
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36. Solid Tumors in Post-Polycythemia Vera and Post-Essential Thrombocythemia Myelofibrosis: A Study on 2220 Patients

Author

Mora, Barbara, primary, Rumi, Elisa, additional, Guglielmelli, Paola, additional, Barraco, Daniela, additional, Maffioli, Margherita, additional, Rambaldi, Alessandro, additional, Caramella, Marianna, additional, Komrokji, Rami S., additional, Gotlib, Jason R., additional, Kiladjian, Jean-Jacques, additional, Cervantes, Francisco, additional, Devos, Timothy, additional, Palandri, Francesca, additional, De Stefano, Valerio, additional, Ruggeri, Marco, additional, Silver, Richard T., additional, Benevolo, Giulia, additional, Albano, Francesco, additional, Cavalloni, Chiara, additional, Pietra, Daniela, additional, Barbui, Tiziano, additional, Rotunno, Giada, additional, Cazzola, Mario, additional, Vannucchi, Alessandro M., additional, Giorgino, Toni, additional, and Passamonti, Francesco, additional

Published
2018
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39. PRM-151 in Myelofibrosis: Efficacy and Safety in an Open Label Extension Study

Author

Verstovsek, Srdan, primary, Hasserjian, Robert P., additional, Pozdnyakova, Olga, additional, Veletic, Ivo, additional, Mesa, Ruben A., additional, Foltz, Lynda, additional, Mascarenhas, John, additional, Ritchie, Ellen K., additional, Palmer, Jeanne, additional, Silver, Richard T., additional, Kremyanskaya, Marina, additional, van den Blink, Bernt, additional, Gupta, Renu, additional, Manshouri, Taghi, additional, Yin, C. Cameron, additional, Estrov, Zeev E., additional, and Gotlib, Jason R., additional

Published
2018
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42. Phase 3 trial of momelotinib (MMB) vs ruxolitinib (RUX) in JAK inhibitor (JAKi) naive patients with myelofibrosis (MF).

Author

Mesa, Ruben A., primary, Kiladjian, Jean-Jacques, additional, Catalano, John V., additional, Devos, Timothy, additional, Egyed, Miklos, additional, Hellman, Andrzei, additional, McLornan, Donal, additional, Shimoda, Kazuya, additional, Winton, Elliott F., additional, Deng, Wei, additional, Dubowy, Ronald L., additional, Maltzman, Julia D., additional, Cervantes, Francisco, additional, and Gotlib, Jason R., additional

Published
2017
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43. Predictive models for splenic response to JAK-inhibitor therapy in patients with myelofibrosis.

Author

Menghrajani, Kamal, Boonstra, Philip S., Mercer, Jessica A., Perkins, Cecelia, Gowin, Krisstina L., Weber, Alissa A., Mesa, Ruben, Gotlib, Jason R., Wang, Lixia, Singer, Jack W., and Talpaz, Moshe

Subjects
MYELOFIBROSIS, PREDICTION models, ALTERNATIVE medicine, SPLEEN, HEMOGLOBINS
Abstract

JAK inhibitors for myelofibrosis (MF) reduce spleen size, control constitutional symptoms, and may improve survival. We studied the clinical characteristics of 548 MF patients treated with JAK inhibitors from 2008 to 2016 to better understand predictors of splenic response. Response was defined as a 50% decrease in spleen size at early (3–4 months on therapy) and late (5–12 months) timepoints after therapy initiation. Early response positively correlated with higher doses of JAK inhibitor, baseline spleen size 5–10 cm, and hemoglobin. Early response negatively correlated with baseline spleen size >20 cm and high WBC. The strongest predictor of late response was whether a patient had a response at the earlier timepoint (OR 8.88). Our response models suggest that clinical factors can be used to predict which patients are more likely to respond to JAK inhibitors, and those who do not achieve an early response, i.e. within 3–4 months, should consider alternative treatments. [ABSTRACT FROM AUTHOR]

Published
2019
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44. Prognostic Factors and Survival Prediction in 1,088 Patients with Mastocytosis Collected in the Registry of the European Competence Network on Mastocytosis (ECNM Registry)

Author

Sperr, Wolfgang R., Kundi, Michael, Elberink, Hanneke Oude, van Anrooij, Bjorn, Gleixner, Karoline V., Hadzijusufovic, Emir, Gorska, Aleksandra, Lange, Magdalena, Rabenhorst, Anja, Merante, Serena, Elena, Chiara, Fortina, Anna Belloni, Fontana, Elena, Schwaab, Juliana, Jawhar, Mohamad, Zanotti, Roberta, Bonadonna, Patrizia, Triggiani, Massimo, Perkins, Cecelia, Gotlib, Jason R., Doubek, Michael, Shoumaryeh, Khalid, Fuchs, David, Sabato, Vito, Brockow, Knut, Bretterklieber, Agnes, Jaekel, Nadja, Reiter, Andreas, Hartmann, Karin, Niedoszytko, Marek, Kluin-Nelemans, Hanneke C., Valent, Peter, Sperr, Wolfgang R., Kundi, Michael, Elberink, Hanneke Oude, van Anrooij, Bjorn, Gleixner, Karoline V., Hadzijusufovic, Emir, Gorska, Aleksandra, Lange, Magdalena, Rabenhorst, Anja, Merante, Serena, Elena, Chiara, Fortina, Anna Belloni, Fontana, Elena, Schwaab, Juliana, Jawhar, Mohamad, Zanotti, Roberta, Bonadonna, Patrizia, Triggiani, Massimo, Perkins, Cecelia, Gotlib, Jason R., Doubek, Michael, Shoumaryeh, Khalid, Fuchs, David, Sabato, Vito, Brockow, Knut, Bretterklieber, Agnes, Jaekel, Nadja, Reiter, Andreas, Hartmann, Karin, Niedoszytko, Marek, Kluin-Nelemans, Hanneke C., and Valent, Peter

Published
2016

45. Effects of Long-Term Ruxolitinib (RUX) on Bone Marrow (BM) Morphology in Patients with Myelofibrosis (MF) Enrolled in the COMFORT-I Study

Author

Kvasnicka, Hans Michael, primary, Thiele, Juergen, additional, Bueso-Ramos, Carlos E., additional, Sun, William, additional, Naim, Ahmad, additional, Svaraman, Smitha, additional, Gao, Jessy, additional, Gotlib, Jason R., additional, Gupta, Vikas, additional, Dao, Kim-Hien, additional, Talpaz, Moshe, additional, Winton, Elliott F., additional, Harvey, Jimmie H., additional, and Verstovsek, Srdan, additional

Published
2016
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46. Clinical Outcomes with Ruxolitinib (RUX) in Patients with Myelofibrosis (MF) Stratified By Transfusion Status: A Pooled Analysis of the COMFORT-I and -II Trials

Author

Gupta, Vikas, primary, Verstovsek, Srdan, additional, Paquette, Ronald, additional, Gotlib, Jason R., additional, Vannucchi, Alessandro M., additional, Kiladjian, Jean-Jacques, additional, Cervantes, Francisco, additional, Sun, William, additional, Gao, Jessy, additional, Langmuir, Peter, additional, Gopalakrishna, Prashanth, additional, and Harrison, Claire N., additional

Published
2016
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48. Prognostic Factors and Survival Prediction in 1,088 Patients with Mastocytosis Collected in the Registry of the European Competence Network on Mastocytosis (ECNM Registry)

Author

Sperr, Wolfgang R., primary, Kundi, Michael, additional, Oude Elberink, Hanneke, additional, van Anrooij, Björn, additional, Gleixner, Karoline V, additional, Hadzijusufovic, Emir, additional, Górska, Aleksandra, additional, Lange, Magdalena, additional, Rabenhorst, Anja, additional, Merante, Serena, additional, Elena, Chiara, additional, Belloni Fortina, Anna, additional, Fontana, Elena, additional, Schwaab, Juliana, additional, Jawhar, Mohamad, additional, Zanotti, Roberta, additional, Bonadonna, Patrizia, additional, Triggiani, Massimo, additional, Perkins, Cecelia, additional, Gotlib, Jason R., additional, Doubek, Michael, additional, Shoumaryeh, Khalid, additional, Fuchs, David, additional, Sabato, Vito, additional, Brockow, Knut, additional, Bretterklieber, Agnes, additional, Jaekel, Nadja, additional, Reiter, Andreas, additional, Hartmann, Karin, additional, Niedoszytko, Marek, additional, Kluin-Nelemans, Hanneke C., additional, and Valent, Peter, additional

Published
2016
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