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3. Metabolic profiles of internal medicine residents

Author

Dwipayana, I Made Pande, primary, Gotera, Wira, additional, Saraswati, Made Ratna, additional, Semadi, I Made, additional, Nugraha, Ida Bagus, additional, Budhiartha, Anak Agung Gede, additional, and Suastika, Ketut, additional

Published
2023
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7. Hyperglycemia and Obesity as Risk Factors for Severe Covid-19

Author

Nugraha, Komang Ida Widiayu Radiari, primary, Rai, Ida Bagus Ngurah, additional, Sajinadiyasa, I Gede Ketut, additional, Gotera, Wira, additional, Candrawati, Ni Wayan, additional, Kusumawardani, Ida Ayu Jasminarti Dwi, additional, Arisanti, Ni Luh Putu Eka, additional, and Artana, I Gusti Ngurah Bagus, additional

Published
2023
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11. Factors Associated with Diabetes-Related Distress in Type 2 Diabetes Mellitus Patients

Author

Bhaskara,Gilang, Budhiarta,Anak Agung Gde, Gotera,Wira, Saraswati,Made Ratna, Dwipayana,I Made Pande, Semadi,I Made Siswadi, Nugraha,Ida Bagus Aditya, Wardani,Ida Aju Kusuma, Suastika,Ketut, Bhaskara,Gilang, Budhiarta,Anak Agung Gde, Gotera,Wira, Saraswati,Made Ratna, Dwipayana,I Made Pande, Semadi,I Made Siswadi, Nugraha,Ida Bagus Aditya, Wardani,Ida Aju Kusuma, and Suastika,Ketut

Abstract

Gilang Bhaskara,1 Anak Agung Gde Budhiarta,2 Wira Gotera,2 Made Ratna Saraswati,2 I Made Pande Dwipayana,2 I Made Siswadi Semadi,2 Ida Bagus Aditya Nugraha,2 Ida Ayu Kusuma Wardani,3 Ketut Suastika2 1Internal Medicine Education Program, Faculty of Medicine, Udayana University, Bali, Indonesia; 2Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia; 3Department of Psychiatry, Sanglah General Hospital, Denpasar, Bali, IndonesiaCorrespondence: Ketut Suastika, Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University, Sanglah General Hospital, Denpasar, Bali, Indonesia, Tel +62 81 138 0916, Email ksuas@unud.ac.idBackground: Diabetes-related distress is a unique emotional problem that is directly related to the burden and anxieties felt by type 2 diabetes mellitus (T2DM) patients. Diabetes-related distress may lead to pessimism and lower self-efficacy which resulted in a deficiency of self-treatment compliance and can cause further bad glycemic control. Knowing the associated factors of diabetic-related distress and solving them may help T2DM patients improve their glycemic control.Methods: This study is an analytical study with cross-sectional design conducted at Sanglah General Hospital from January to April 2021. The data were taken using the consecutive sampling method; 124 samples were collected according to inclusion and exclusion criteria. The participants filled Diabetes Distress Scale questionnaire (DDS17 Bahasa Indonesia). The data analysis was done using univariate (descriptive), bivariate (chi-square) and multivariate (logistic regression) analysis.Results: Seventy-five subjects out of 124 (60.5%) had diabetes-related distress. The associated factors of diabetes-related distress one among others are the insulin usage as diabetic therapy (OR= 8.30, 95% CI 2.24– 30.72; p = 0.002), had a hypo

Published
2022

22. Dyslipidemia in diabetes: a population-based study in Bali

Author

Suastika,Ketut, Semadi,I Made Siswadi, Dwipayana,I Made Pande, Saraswati,Made Ratna, Gotera,Wira, Budhiarta,Anak Agung Gde, Matsumoto,Kinuyo, Kajiwara,Naemi, and Taniguchi,Hiroshi

Subjects
nutritional and metabolic diseases, lipids (amino acids, peptides, and proteins), International Journal of General Medicine
Abstract

Ketut Suastika,1 I Made Siswadi Semadi,1 I Made Pande Dwipayana,1 Made Ratna Saraswati,1 Wira Gotera,1 Anak Agung Gde Budhiarta,1 Kinuyo Matsumoto,2 Naemi Kajiwara,2 Hiroshi Taniguchi31Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/Sanglah Hospital, Denpasar, Bali, Indonesia; 2Graduate School of Life Science, Kobe Women’s University, Kobe, Japan; 3Department of Diabetology, Graduate School of Health Sciences, Kobe University, Kobe, JapanCorrespondence: Ketut SuastikaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Udayana University/Sanglah Hospital, Jalan Kamboja, Denpasar, Bali, IndonesiaTel +62 81 138 0916Email ksuas@unud.ac.idPurpose: To establish the lipid pattern in subjects with diabetes mellitus (DM) and factors that are correlated with insulin resistance and lipid disorders in a population of Bali.Methods: A cross-sectional population-based study which enrolled 1840 subjects (age 13–100 years) from 7 villages was carried out. Several clinical parameters were measured including age, gender, body mass index, waist circumference (WC), fasting blood glucose, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein (apo) A (apoA), apoB, non-HDL-C, T/HDL-C ratio, LDL-C/apoB ratio, apoB/A ratio, plasma insulin, and homeostasis of model assessment-insulin resistance (HOMA-IR).Results: TC, TG, and non-HDL-C levels were higher in DM subjects than in normal glucose tolerance (NGT) subjects in both genders; total/HDL-C ratio was higher in subjects with DM than in NGT subjects only in men; LDL-C levels, apoB levels, and apoB/A ratios were higher and LDL/apoB was lower in subjects with DM than in NGT in women. In subjects with DM, the target for LDL-C (79%), non-HDL-C (85.2%), apoB (80%), HDL-C (34.9%), TG (46.7%), and small-dense low density lipoprotein (42.2%) was not achieved.Conclusion: FBG was correlated with TC, TG, LDL-C, apoB, non-HDL-C levels, LDL/apoB, and apoB/apoA ratios. Subjects with DM had higher levels of TC, TG, and non-HDL-C levels in both genders; T/HDL-C ratio only in men; LDL-C, apoB/apoA ratio and lower LDL/apoB ratio only in women. Obesity was correlated with lipid levels. WC was correlated with LDL/apoB ratio, insulin level, HOMA-IR, and TG; highest absolute strength of correlation was with LDL/apoB ratio. Insulin resistance was correlated with lipid levels or ratios, especially in women. In women, HOMA-IR had a positive correlation with total/HDL-C ratio, non-HDL-C, apoB, and a negative correlation with HDL-C levels.Keywords: HOMA-IR, dyslipidemia, diabetes

Published
2019

31. Underweight is an important risk factor for coronary heart disease in the population of Ceningan Island, Bali

Author

Suastika, Ketut, primary, Dwipayana, Pande, additional, Saraswati, Made Ratna, additional, Gotera, Wira, additional, Budhiarta, Anak Agung Gde, additional, Sutanegara, Nengah Dwi, additional, Gunadi, Gusti Ngurah Putra, additional, Nadha, Ketut Badjra, additional, Wita, Wayan, additional, Rina, Ketut, additional, Santoso, Anwar, additional, Soegondo, Sidartawan, additional, Kajiwara, Naemi, additional, and Taniguchi, Hiroshi, additional

Published
2011
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32. Underweight is an important risk factor for coronary heart disease in the population of Ceningan Island, Bali.

Author

Suastika, Ketut, Dwipayana, Pande, Saraswati, Made Ratna, Gotera, Wira, Budhiarta, Anak Agung Gde, Sutanegara, Nengah Dwi, Gunadi, Gusti Ngurah Putra, Nadha, Ketut Badjra, Wita, Wayan, Rina, Ketut, Santoso, Anwar, Soegondo, Sidartawan, Kajiwara, Naemi, and Taniguchi, Hiroshi

Abstract

A study on the prevalence of coronary heart disease (CHD) and its risk factors in Ceningan Island was conducted. The prevalence of CHD was 11.5%. Older age (odds ratio, OR, 27.0), underweight (OR, 3.6), systolic hypertension (OR, 4.6), high total cholesterol (OR, 5.9), and high low-density lipoprotein cholesterol (OR, 3.1) were risk factors for a history of myocardial infarction (MI). By logistic regression analysis, only age (B=3.937) and underweight (B=1.275) consistently appeared to be risk factors for MI. The prevalence of CHD in the population was comparatively high. [ABSTRACT FROM PUBLISHER]

Published
2012
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33. Challenging Diagnosis of Addison’s Disease Presenting with Adrenal Crisis

Author

Wayan Wina Dharmesti, Ni, Ratna Saraswati, Made, Suastika, Ketut, Gotera, Wira, and Made Pande Dwipayana, I

Abstract

Primary adrenal insufficiency, also known as Addison’s disease, is a rare but potentially fatal condition resulting from the failure of the adrenal cortex to produce glucocorticoid and/or mineralocorticoid hormones. Unfortunately, the clinical manifestation of primary adrenal insufficiency is not specific and often progresses insidiously, resulting in late diagnosis, or in severe cases, life-threatening circulatory collapse. Adrenal insufficiency should be considered in patients with unexplained vascular collapse. We report the case of a woman who presented to the emergency ward with unexplainable shock that was later diagnosed as adrenal crisis due to Addison’s disease. The presence of hyperpigmentation in patients with rapid progression of adrenal insufficiency suggests the diagnosis of Addison’s disease presenting with adrenal crisis.

Published
2021
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34. Intravenous methylcobalamin effectively ameliorated painful diabetic neuropathy: A randomized double-blind placebo controlled trial.

Author

Purwata, Thomas Eko, Eka Widyadharma, I. Putu, Rudy, Made, Soejitno, Andreas, Gotera, Wira, and Suryana, Ketut

Subjects
*DIABETIC neuropathies, *PAIN management, *VITAMIN B12, *SALINE injections, *PLACEBOS
Abstract

Objective. Painful diabetic neuropathy (PDN) is a prevalent debilitating consequence of diabetes mellitus with lack of satisfactory therapeutic options. Methylcobalamin (MeCbl) is one of vitamin B12 analogs with known neurotrophic effects. We aimed to determine if MeCbl can relieve PDN. Materials and methods. This was a randomized (1:1) double-blind placebo-controlled trial involving PDN patients. Treatment and control group received daily 12.5 mg oral amitriptyline bid with either 500 μg of intravenous MeCbl or saline injection given on alternating days, respectively, for a 9-consecutive day period. PDN was assessed with douleur neuropathique 4 (DN4) questionnaire. Numeric pain rating scale (NPRS) was used to monitor pain intensity and treatment response. All investigators and patients were kept blinded throughout the study period. Outcomes. 42 patients, 21 on each arm had completed the study. The NPRS reduction can already be observed as early as day 2 post-intervention. Both the treatment and control group demonstrated sustained reduction of NPRS by almost one point per each time point of evaluation in the first three days (p<0.001). NPRS reduction remained until the end of the study period. The treatment group had a significantly lower NPRS score by 1.29 than that of the control group during the entire study period (95% CI -1.84 – -0.75; p < 0.001). Treatment group experienced significantly higher NPRS reduction when compared with control (4.19±1.54 vs. 2.1± 0.83; 95% CI 1.32-2.87; p < 0.001), i.e. 62.6% from baseline. Conclusions. MeCbl significantly and safely relieved PDN in a relatively rapid onset. [ABSTRACT FROM AUTHOR]

Published
2021
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35. Correlation between Waist Circumference and IGF-1 Levels in an Elderly Population in Bali, Indonesia.

Author

Dwipayana IMP, Gotera W, Saraswati MR, Semadi IMS, Nugraha IBA, Suastika K, Budhiarta AAG, Amrita P, and Putra WP

Subjects
Humans, Indonesia epidemiology, Male, Female, Aged, Cross-Sectional Studies, Aged, 80 and over, Middle Aged, Obesity, Abdominal epidemiology, Obesity, Abdominal diagnosis, Insulin-Like Growth Factor I metabolism, Insulin-Like Growth Factor I analysis, Waist Circumference
Abstract

Background: Hyperinsulinemia due to insulin resistance is hypothesized to act as a promotor of cancer growth. In addition to the direct effects of hyperinsulinemia on cancer cells, the stimulation of tumor cell growth can also be indirectly mediated through growth factors and receptors such as insulin-like growth factor 1 (IGF-1). Increased cancer risk is also associated with increased adipose tissue, such as in abdominal obesity, due to the higher risk of insulin resistance and hyperinsulinemia. Waist circumference is a parameter that indicates an individual's level of adiposity. In addition, the risk of cancer also increases in the elderly as they age. This study aims to assess the correlation between waist circumference and IGF-1 levels in the elderly population in Bali, Indonesia., Methodology: This study used a cross-sectional analytical design conducted in the Melinggih Village, Gianyar Regency. The study was conducted in September 2023. This study has been approved by the Research Ethics Commission number 2020/UN14.2.2.VII.14/LT/2023. The study population included elderly individuals residing in the Melinggih Village who were willing to participate. Data analysis encompassed descriptive analysis and the Spearman correlation test., Result: A total of 88 subjects participated in the study, consisting of 57 females (64.8%) and 31 males (35.2%). A statistically significant but weak correlation coexists between waist circumference and IGF-1 levels., Conclusion: A weak but statistically significant positive correlation was found between waist circumference and IGF-1 levels in the elderly. However, because of the small sample size, another study with a bigger sample size with enough power to investigate this association needs to be done to validate the results of the current study., Competing Interests: The authors declared no conflict of interest., (© 2024 Journal of the ASEAN Federation of Endocrine Societies.)

Published
2024
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