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3. Reply to Eker et al. Comment on Kilian et al. Comparing Characteristics and Treatment of Brain Vascular Malformations in Children and Adults with HHT. J. Clin. Med. 2023, 12, 2704.

Author

Kilian, Alexandra, Latino, Giuseppe, White, Andrew, Ratjen, Felix, McDonald, Jamie, Whitehead, Kevin, Gossage, James, Krings, Timo, Lawton, Michael, Kim, Helen, and Faughnan, Marie

Abstract

We are grateful to Eker et al. for their thoughtful analysis and response to our publication titled Comparing Characteristics and Treatment of Brain Vascular Malformations in Children and Adults with HHT [...].

Published
2023

4. EAES Multidisciplinary Rapid Guideline: systematic review, meta-analysis, GRADE assessment and evidence-informed recommendations on the surgical management of paraesophageal hernias

Author

Markar, Sheraz R., Menon, Nainika, Guidozzi, Nadia, Kontouli, Katerina-Maria, Mavridis, Dimitrios, Andreou, Alexandros, Berlth, Felix, Bonavina, Luigi, Cushieri, Alfred, Fourie, Lana, Gossage, James, Gronnier, Caroline, Hazebroek, Eric J., Krishnadath, Sheila, Low, Donald E., McCord, Mimi, Pouw, Roos E., Watson, David I., Carrano, Francesco Maria, Ortenzi, Monica, and Antoniou, Stavros A.

Published
2023
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5. Comparing Characteristics and Treatment of Brain Vascular Malformations in Children and Adults with HHT

Author

Kilian, Alexandra, Latino, Giuseppe A, White, Andrew J, Ratjen, Felix, McDonald, Jamie, Whitehead, Kevin J, Gossage, James R, Krings, Timo, Lawton, Michael T, Kim, Helen, Faughnan, Marie E, and Group, The Brain Vascular Malformation Consortium HHT Investigator

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pediatric Research Initiative, Hematology, Congenital Structural Anomalies, Rare Diseases, Orphan Drug, Prevention, Pediatric, Clinical Research, Brain Disorders, Neurosciences, hereditary hemorrhagic telangiectasia, pediatrics, brain vascular malformation, embolization, gamma knife, surgery, intracranial hemorrhage, screening, Biomedical and clinical sciences
Abstract

Hereditary hemorrhagic telangiectasia (HHT) is a rare autosomal dominant disease characterized by the development of vascular malformations (VMs) in organs such as the brain and lungs, as well as telangiectases on mucosal surfaces. Prophylactic treatment of organ VMs may prevent potential complications, such as hemorrhage. However, brain VM treatment-surgical resection, embolization, and/or radiosurgery-is not recommended for all patients due to the associated risks. Given the scarcity of data regarding HHT-related brain VM presentation and treatment trends in pediatric patients, we aim to describe the clinical presentations and the patterns of treatment of HHT-related brain VMs in a pediatric cohort, and compare pediatric trends to those of adults. Demographic and clinical data were analyzed in 114 pediatric patients with HHT-related brain VMs and compared with a cohort of 253 adult patients enrolled in the multicenter Brain Vascular Malformation Consortium HHT Project. Our data demonstrated that a higher proportion of pediatric patients with HHT-related brain VMs were symptomatic at presentation (p = 0.004). Moreover, a higher proportion of pediatric patients presented with intracranial hemorrhage (p < 0.001) and seizure (p = 0.002) compared to adult patients. Surgical resection was the most common brain VM treatment modality in both children and adults. We conclude that pediatric patients may be more likely to present with symptoms and complications from brain VMs, supporting the case for screening for brain VMs in children with HHT.

Published
2023

7. Statistical analysis plan for the biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2) study: An international randomised controlled multicentre trial

Author

Wempe, Carola, Storck, Michael, Brix, Tobias, Strauss, Christian, Sadjadi, Mahan, Weiss, Raphael, Booke, Hendrik, Loomann, Lisa, Amini, Wida, Meschede, Dana, Göbel, Ulrich, Haaker, Jan Gerrit, Brenner, Thorsten, Espeter, Florian, Rahmel, Tim, Adamzik, Michael, Brandenburger, Timo, Putensen, Christian, Bode, Christian, Kruse, Philippe, Wild, Lennart, Rosenberger, Peter, Bernard, Alice, Jung-König, Mona, Larmann, Jan, Reutershan, Jörg, Arndt, Christian, Vojnar, Benjamin, Spieth, Peter M., Schneider, Antoine, Monard, Céline, Mura, Benedetta, Villa, Gianluca, Laici, Cristiana, Siniscalchi, Antonio, Capozzi, Chiara, Sita, Marco, Cattin, Lucia, de Rosa, Silvia, Spadaro, Savino, Franco, D'Arcangelo Benito, Ostermann, Marlies, Gossage, James, Verzelloni, Alessandra, Scaramuzzi, Marco, Glass, Adam, Silversides, Jon, Lonsdale, Elliot, Forni, Lui G., Haider, Syeda, Rossiter, Adam, Welters, Ingeborg, Hoste, Eric, Hollmann, Markus W., Ripollés-Melchor, Javier, Fernández-Valdes-Bango, Paula, Parise-Roux, Diego, Martin González, Maria Carmen, Bathal, Irene Romero, Jáuregui, Maider Puyada, Navarro-Perez, Rosalía, De Soto, Inés, García-Álvarez, Raquel, Sánchez, Elena Murcia, Suarez-de-la-Rica, Alejandro, Lalande, Robin, von Groote, Thilo, Danzer, Moritz Fabian, Meersch, Melanie, Zarbock, Alexander, and Gerß, Joachim

Published
2024
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8. Multi-Omic Analysis of Esophageal Adenocarcinoma Uncovers Candidate Therapeutic Targets and Cancer-Selective Posttranscriptional Regulation

Author

Fitzgerald, Rebecca C., Edwards, Paul A.W., Grehan, Nicola, Nutzinger, Barbara, Loreno, Christine, Redmond, Aisling M., Abbas, Sujath, Freeman, Adam, Smyth, Elizabeth C., O'Donovan, Maria, Miremadi, Ahmad, Malhotra, Shalini, Tripathi, Monika, Cheah, Calvin, Coles, Hannah, Millington, Curtis, Devonshire, Ginny, Eldridge, Matthew, Secrier, Maria, Jammula, Sriganesh, Davies, Jim, Crichton, Charles, Carroll, Nick, Hardwick, Richard H., Safranek, Peter, Hindmarsh, Andrew, Sujendran, Vijayendran, Hayes, Stephen J., Ang, Yeng, Sharrocks, Andrew, Preston, Shaun R., Bagwan, Izhar, Save, Vicki, Skipworth, Richard J.E., Hupp, Ted R., O'Neill, J Robert, Tucker, Olga, Beggs, Andrew, Taniere, Philippe, Puig, Sonia, Contino, Gianmarco, Underwood, Timothy J., Walker, Robert C., Grace, Ben L., Lagergren, Jesper, Gossage, James, Davies, Andrew, Chang, Fuju, Mahadeva, Ula, Goh, Vicky, Ciccarelli, Francesca D., Sanders, Grant, Berrisford, Richard, Chan, David, Cheong, Ed, Kumar, Bhaskar, Sreedharan, L., Parsons, Simon L., Soomro, Irshad, Kaye, Philip, Saunders, John, Lovat, Laurence, Haidry, Rehan, Scott, Michael, Sothi, Sharmila, Lishman, Suzy, Hanna, George B., Peters, Christopher J., Moorthy, Krishna, Grabowska, Anna, Turkington, Richard, McManus, Damian, Coleman, Helen, Petty, Russell D., Bartlet, Freddie, O'Neill, J. Robert, Yébenes Mayordomo, Marcos, Mitulović, Goran, Al Shboul, Sofian, Bedran, Georges, Faktor, Jakub, Hernychova, Lenka, Uhrik, Lukas, Gómez-Herranz, Maria, Kocikowski, Mikołaj, Vojtěšek, Bořivoj, Arends, Mark J., Hupp, Ted, and Alfaro, Javier Antonio

Published
2024
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9. De Novo Brain Vascular Malformations in Hereditary Hemorrhagic Telangiectasia

Author

Atherton, Mary E., Chakinala, Murali M., Clancy, Marianne S., Faughnan, Marie E., Gossage, James R., Hammill, Adrienne M., Henderson, Katharine, Hetts, Steven, Hountras, Peter, Iyer, Vivek, Kasthuri, Raj S., Kim, Helen, Krings, Timo, Lawton, Michael T., Lin, Doris, Mager, Johannes Jurgen, Marchuk, Douglas A., McWilliams, Justin P., McDonald, Jamie, Pawlikowska, Ludmila, Pollak, Jeffrey, Ratjen, Felix, Swanson, Karen, Vethanayagam, Dilini, Weinsheimer, Shantel, White, Andrew J., Whitehead, Kevin J., Wilcox, Pearce, Beslow, Lauren A., Hetts, Steven W., McCulloch, Charles E., Clancy, Marianne, and Bagheri, Negar

Published
2024
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15. Multicenter, Prospective Cohort Study of Oesophageal Injuries and Related Clinical Outcomes (MUSOIC study)

Author

Owen, Richard P., Chidambaram, Swathikan, Griffiths, Ewen A., Sultan, Javed, Phillips, Alexander W., Vohra, Ravindra, Preston, Shaun, Gossage, James, Hanna, George B., Underwood, Tim J., Maynard, Nick, Markar, Sheraz R., Scabbiolo, Zoe, Kawka, Michal, Burke, Rosemary, Evans, Richard, Shang, Ersong, Gill, Rajinder, Lee, Rachel, Ong, Zun Zheng, Bull, Alexander, and Walker, Robert

Published
2023
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17. Delayed Surgical Intervention After Chemoradiotherapy in Esophageal Cancer: (DICE) Study

Author

Chidambaram, Swathikan, Owen, Richard, Sgromo, Bruno, Chmura, Magdalena, Kisiel, Aaron, Evans, Richard, Griffiths, Ewen A., Castoro, Carlo, Gronnier, Caroline, MaoAwyes, Mometo Ali, Gutschow, Christian A., Piessen, Guillaume, Degisors, Sébastien, Alvieri, Rita, Feldman, Hope, Capovilla, Giovanni, Grimminger, Peter P., Han, Shiwei, Low, Donald E., Moore, Jonathan, Gossage, James, Voeten, Dan, Gisbertz, Suzanne S., Ruurda, Jelle, van Hillegersberg, Richard, D’Journo, Xavier B., Chmelo, Jakub, Phillips, Alexander W., Rosati, Riccardo, Hanna, George B., Maynard, Nick, Hofstetter, Wayne, Ferri, Lorenzo, Berge Henegouwen, Mark I., and Markar, Sheraz R.

Published
2023
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18. Genotype-Phenotype Correlations in Children with HHT.

Author

Kilian, Alexandra, Latino, Giuseppe A, White, Andrew J, Clark, Dewi, Chakinala, Murali M, Ratjen, Felix, McDonald, Jamie, Whitehead, Kevin, Gossage, James R, Lin, Doris, Henderson, Katharine, Pollak, Jeffrey, McWilliams, Justin P, Kim, Helen, Lawton, Michael T, Faughnan, Marie E, and the Brain Vascular Malformation Consortium HHT Investigator Group

Subjects
the Brain Vascular Malformation Consortium HHT Investigator Group, ACVRL1, ENG, Hereditary hemorrhagic telangiectasia, SMAD4, arteriovenous malformation, genotype–phenotype correlation, pediatrics, genotype-phenotype correlation, Clinical Sciences
Abstract

Hereditary hemorrhagic telangiectasia (HHT), a rare autosomal dominant disease mostly caused by mutations in three known genes (ENG, ACVRL1, and SMAD4), is characterized by the development of vascular malformations (VMs). Patients with HHT may present with mucocutaneous telangiectasia, as well as organ arteriovenous malformations (AVMs) of the central nervous system, lungs, and liver. Genotype-phenotype correlations have been well described in adults with HHT. We aimed to investigate genotype-phenotype correlations among pediatric HHT patients. Demographic, clinical, and genetic data were collected and analyzed in 205 children enrolled in the multicenter Brain Vascular Malformation Consortium HHT Project. A chi-square test was used to determine the association between phenotypic presentations and genotype. Among 205 patients (age range: 0-18 years; mean: 11 years), ENG mutation was associated with the presence of pulmonary AVMs (p < 0.001) and brain VM (p < 0.001). The presence of a combined phenotype-defined as both pulmonary AVMs and brain VMs-was also associated with ENG mutation. Gastrointestinal bleeding was rare (4.4%), but was associated with SMAD4 genotype (p < 0.001). We conclude that genotype-phenotype correlations among pediatric HHT patients are similar to those described among adults. Specifically, pediatric patients with ENG mutation have a greater prevalence of pulmonary AVMs, brain VMs, and a combined phenotype.

Published
2020

21. Pazopanib may reduce bleeding in hereditary hemorrhagic telangiectasia

Author

Faughnan, Marie E, Gossage, James R, Chakinala, Murali M, Oh, S Paul, Kasthuri, Raj, Hughes, Christopher CW, McWilliams, Justin P, Parambil, Joseph G, Vozoris, Nicholas, Donaldson, Jill, Paul, Gitanjali, Berry, Pamela, and Sprecher, Dennis L

Subjects
Biochemistry and Cell Biology, Biological Sciences, Rare Diseases, Hematology, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adult, Female, Hemorrhage, Humans, Indazoles, Male, Middle Aged, Pyrimidines, Sulfonamides, Telangiectasia, Hereditary Hemorrhagic, Telangiectasia, Hereditary, Epistaxis, Anemia, Tyrosine kinase inhibitor, Clinical Sciences, Pharmacology and Pharmaceutical Sciences, Oncology & Carcinogenesis, Biochemistry and cell biology
Abstract

Pazopanib (Votrient) is an orally administered tyrosine kinase inhibitor that blocks VEGF receptors potentially serving as anti-angiogenic treatment for hereditary hemorrhagic telangiectasia (HHT). We report a prospective, multi-center, open-label, dose-escalating study [50 mg, 100 mg, 200 mg, and 400 mg], designed as a proof-of-concept study to demonstrate efficacy of pazopanib on HHT-related bleeding, and to measure safety. Patients, recruited at 5 HHT Centers, required ≥ 2 Curacao criteria AND [anemia OR severe epistaxis with iron deficiency]. Co-primary outcomes, hemoglobin (Hgb) and epistaxis severity, were measured during and after treatment, and compared to baseline. Safety monitoring occurred every 1.5 weeks. Seven patients were treated with 50 mg pazopanib daily. Six/seven showed at least 50% decrease in epistaxis duration relative to baseline at some point during study; 3 showed at least 50% decrease in duration during Weeks 11 and 12. Six patients showed a decrease in ESS of > 0.71 (MID) relative to baseline at some point during study; 3/6 showed a sustained improvement. Four patients showed > 2 gm improvement in Hgb relative to baseline at one or more points during study. Health-related QOL scores improved on all SF-36 domains at Week 6 and/or Week 12, except general health (unchanged). There were 19 adverse events (AE) including one severe AE (elevated LFTs, withdrawn from dosing at 43 days); with no serious AE. In conclusion, we observed an improvement in Hgb and/or epistaxis in all treated patients. This occurred at a dose much lower than typically used for oncologic indications, with no serious AE. Further studies of pazopanib efficacy are warranted.

Published
2019

24. Esophageal and gastric malignancies after bariatric surgery: a retrospective global study

Author

Gallardo, Carlos Sosa, Agustin, Cataldo, Wright, Fernando, Fuente, Ignacio, Carbajo, Miguel, Cal, Patricio, Chisholm, Jacob, Kow, Lilian, Tan, Michael H.L., Gan, Philip, Gananadha, Sivakumar, Felsenreich, Daniel M., Prager, Gerhard, Matthys, Chris, Himpens, Jacques M., Focquet, Marc A.M.R.M., Ramos, Almino, Nato, Manoel Galvano, Vidal, Thiago, Andalib, Amin, Siblini, Aya, Ferri, Lorenzo, Abdarabo, Lina, Nevo, Yehonatan, Pescarus, Radu, Yang, Wah, Hamed, Hosam, Liagre, Arnaud, Bergeat, Damien, Marie, De Montrichard, Martini, Francesco, Regis, François, Genser, Laurent, Skalli, Mehdi, Nedelcu, Marius, Smejkal, Milan, Kassir, Radwan, Nicolas, Regenet, Stier, Christine, Nedelcut, Dan-Sebastian, Christodoulidis, Grigorios, Vennapusa, Amar, Kermansaravi, Mohammad, Raziel, Asnat, Sakran, Nasser, Oldani, Alberto, Boru, Cristian Eugeniu, Mécheri, Fouzia, Ciccarese, Francesca, Cesana, Giovanni Carlo, Musella, Mario, Uccelli, Matteo, Foletto, Mirto, Auricchio, Pasquale, Olmi, Stefano, Seki, Yosuke, Kasteleijn, Anne, Van 'T Hof, Gerhard, Apers, Jan A., Hart, Judith W.H., Van De Sande, Justin S.L., Takkenberg, Marijn, Feskens, Pierre B.G.M., Snoekx, Rob, Plat, Victor D., Sandvik, Jorunn, Kalinowski, Piotr, Nabais, Celso, Al-Bahrani, Ahmed Z., Al Zoubi, Mohammad, Bettonica, Carla, Osorio, Javier, Tejedor-Tejada, Javier, Sanz, Lourdes M., Cuadrado, Marta, Moorjani, Rajesh Gianchandani, Yannick, Fringeli, Suter, Michel, Borbély, Yves, Joerg, Zehetner, Barajas-Gamboa, Juan S., Kroh, Matthew, Kisiel, Aaron P., Kamocka, Anna, Immanuel, Arul, Sgromo, Bruno, Gopinath, Bussa, Khoo, David, Mukherjee, Samrat, Pournaras, Dimitrios, Underwood, Tim, Griffiths, Ewen A., Miller, Glenn V., Jaretzke, Helen, Dmitrewski, Jan, Wadley, Martin S., Al-Housni, Ragad, Gillies, Richard S., Singhal, Rishi, Preston, Shaun R., Robinson, Steven John, Hawkins, William J., Adamo, Marco, El Kalaawy, Mohamed, Gossage, James, Crawford, Christopher B., Jaruvongvanich, Veeravich, Parmar, Chetan, Zakeri, Roxanna, Abouelazayem, Mohamed, Shin, Thomas H., Aminian, Ali, Mahmoud, Tala, Abu Dayyeh, Barham K., Wee, Melissa Y., Fischer, Laura, Daams, Freek, and Mahawar, Kamal

Published
2022
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25. Multicentre validation of CT grey-level co-occurrence matrix features for overall survival in primary oesophageal adenocarcinoma.

Author

O'Shea, Robert, Withey, Samuel J., Owczarczyk, Kasia, Rookyard, Christopher, Gossage, James, Godfrey, Edmund, Jobling, Craig, Parsons, Simon L., Skipworth, Richard J. E., Goh, Vicky, Fitzgerald, Rebecca C., Edwards, Paul A. W., Grehan, Nicola, Nutzinger, Barbara, Redmond, Aisling M., Abbas, Sujath, Freeman, Adam, Smyth, Elizabeth C., O'Donovan, Maria, and Miremadi, Ahmad

Subjects
OVERALL survival, ESOPHAGEAL tumors, DISEASE risk factors, ESOPHAGEAL cancer, SURVIVAL rate
Abstract

Background: Personalising management of primary oesophageal adenocarcinoma requires better risk stratification. Lack of independent validation of proposed imaging biomarkers has hampered clinical translation. We aimed to prospectively validate previously identified prognostic grey-level co-occurrence matrix (GLCM) CT features for 3-year overall survival. Methods: Following ethical approval, clinical and contrast-enhanced CT data were acquired from participants from five institutions. Data from three institutions were used for training and two for testing. Survival classifiers were modelled on prespecified variables ('Clinical' model: age, clinical T-stage, clinical N-stage; 'ClinVol' model: clinical features + CT tumour volume; 'ClinRad' model: ClinVol features + GLCM_Correlation and GLCM_Contrast). To reflect current clinical practice, baseline stage was also modelled as a univariate predictor ('Stage'). Discrimination was assessed by area under the receiver operating curve (AUC) analysis; calibration by Brier scores; and clinical relevance by thresholding risk scores to achieve 90% sensitivity for 3-year mortality. Results: A total of 162 participants were included (144 male; median 67 years [IQR 59, 72]; training, 95 participants; testing, 67 participants). Median survival was 998 days [IQR 486, 1594]. The ClinRad model yielded the greatest test discrimination (AUC, 0.68 [95% CI 0.54, 0.81]) that outperformed Stage (ΔAUC, 0.12 [95% CI 0.01, 0.23]; p =.04). The Clinical and ClinVol models yielded comparable test discrimination (AUC, 0.66 [95% CI 0.51, 0.80] vs. 0.65 [95% CI 0.50, 0.79]; p >.05). Test sensitivity of 90% was achieved by ClinRad and Stage models only. Conclusions: Compared to Stage, multivariable models of prespecified clinical and radiomic variables yielded improved prediction of 3-year overall survival. Clinical relevance statement: Previously identified radiomic features are prognostic but may not substantially improve risk stratification on their own. Key Points: • Better risk stratification is needed in primary oesophageal cancer to personalise management. • Previously identified CT features—GLCM_Correlation and GLCM_Contrast—contain incremental prognostic information to age and clinical stage. • Compared to staging, multivariable clinicoradiomic models improve discrimination of 3-year overall survival. [ABSTRACT FROM AUTHOR]

Published
2024
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26. National Institute for Health and Care Excellence (NICE) guidance on monitoring and management of Barrett’s oesophagus and stage I oesophageal adenocarcinoma

Author

di Pietro, Massimiliano, primary, Trudgill, Nigel J, additional, Vasileiou, Melina, additional, Longcroft-Wheaton, Gaius, additional, Phillips, Alexander W, additional, Gossage, James, additional, Kaye, Philip V, additional, Foley, Kieran G, additional, Crosby, Tom, additional, Nelson, Sophie, additional, Griffiths, Helen, additional, Rahman, Muksitur, additional, Ritchie, Gill, additional, Crisp, Amy, additional, Deed, Stephen, additional, and Primrose, John N, additional

Published
2024
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28. Serial ctDNA detection using a personalized, tumor-informed assay in esophageal adenocarcinoma patients following resection

Author

Ococks, Emma, Sharma, Shruti, Tian Ng, Alvin Wei, Aleshin, Alexey, Fitzgerald, Rebecca C., Smyth, Elizabeth, Edwards, Paul A.W., Grehan, Nicola, Nutzinger, Barbara, Fidziukiewicz, Elwira, Redmond, Aisling M., Northrop, Alex, Abbas, Sujath, Smyth, Elizabeth C., O’Donovan, Maria, Miremadi, Ahmad, Malhotra, Shalini, Tripathi, Monika, Grantham, Amber, Cheah, Calvin, Coles, Hannah, Flint, Connor, Eldridge, Matthew, Secrier, Maria, Devonshire, Ginny, Jammula, Sriganesh, Davies, Jim, Crichton, Charles, Carroll, Nick, Hardwick, Richard H., Safranek, Peter, Hindmarsh, Andrew, Sujendran, Vijayendran, Hayes, Stephen J., Ang, Yeng, Sharrocks, Andrew, Preston, Shaun R., Bagwan, Izhar, Save, Vicki, Skipworth, Richard J.E., Hupp, Ted R., O’Neill, J. Robert, Tucker, Olga, Beggs, Andrew, Taniere, Philippe, Puig, Sonia, Contino, Gianmarco, Underwood, Timothy J., Walker, Robert C., Grace, Ben L., Lagergren, Jesper, Gossage, James, Davies, Andrew, Chang, Fuju, Mahadeva, Ula, Goh, Vicky, Ciccarelli, Francesca D., Sanders, Grant, Berrisford, Richard, Chan, David, Cheong, Ed, Kumar, Bhaskar, Sreedharan, L., Parsons, Simon L., Soomro, Irshad, Kaye, Philip, Saunders, John, Lovat, Laurence, Haidry, Rehan, Scott, Michael, Sothi, Sharmila, Lishman, Suzy, Hanna, George B., Peters, Christopher J., Moorthy, Krishna, Grabowska, Anna, Turkington, Richard, McManus, Damian, Coleman, Helen, and Petty, Russell D.

Published
2021
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29. Endoscopic tumour morphology impacts survival in adenocarcinoma of the oesophagus

Author

Fitzgerald, R.C., Noorani, A., Edwards, P.A.W., Grehan, N., Nutzinger, B., Hughes, C., Fidziukiewicz, E., MacRae, S., Northrop, A., Contino, G., Li, X., de la Rue, R., Katz-Summercorn, A., Abbas, S., Loureda, D., O'Donovan, M., Miremadi, A., Malhotra, S., Tripathi, M., Tavaré, S., Lynch, A.G., Eldridge, M., Secrier, M., Devonshire, G., Perner, J., Jammula, S., Davies, J., Crichton, C., Carroll, N., Safranek, P., Hindmarsh, A., Sujendran, V., Hayes, S.J., Ang, Y., Sharrocks, A., Preston, S.R., Oakes, S., Bagwan, I., Save, V., Skipworth, R.J.E., Hupp, T.R., O'Neill, J.R., Tucker, O., Beggs, A., Taniere, P., Puig, S., Underwood, T.J., Walker, R.C., Grace, B.L., Barr, H., Shepherd, N., Old, O., Lagergren, J., Davies, A., Chang, F., Goh, V., Ciccarelli, F.D., Sanders, G., Berrisford, R., Harden, C., Lewis, M., Cheong, E., Kumar, B., Parsons, S.L., Soomro, I., Kaye, P., Saunders, J., Lovat, L., Haidry, R., Igali, L., Scott, M., Sothi, S., Suortamo, S., Lishman, S., Hanna, G.B., Moorthy, K., Peters, C.J., Grabowska, A., Turkington, R., McManus, D., Coleman, H., Khoo, D., Fickling, W., Knight, William R.C., McEwen, Ricardo, Byrne, Ben E., Habib, Wais, Bott, Rebecca, Zylstra, Janine, Mahadeva, Ula, and Gossage, James A.

Published
2020
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37. Management of paraesophageal hiatus hernia

Author

Gerdes, Stephan, Schoppmann, Sebastian F, Bonavina, Luigi, Boyle, Nicholas, Mueller-Stich, Beat P, Gutschow, Christian A, Gisbertz, Suzanne Sarah, Kockerling, Ferdinand, Lehmann, Thorsten G, Lorenz, Dietmar, Granderath, Frank Alexander, Rosati, Riccardo, Wullstein, Christoph, Lundell, Lars, Cheong, Edward, Nafteux, Philippe, Olmi, Stefano, Monig, Stefan, Biebl, Matthias, Leers, Jessica, Zehetner, Joerg, Kristo, Ivan, Berrisford, Richard George, Skrobic, Ognjan M, Simic, Aleksandar P, Pera, Manuel, Grimminger, Peter Philipp, Gockel, Ines, Zarras, Konstantinos, Nieuwenhuijs, Vincent Bernard, Gossage, James A, Henegouwen, Mark I van Berge, Stein, Hubert J, Markar, Sheraz R, Hueting, Willem Eduard, Targarona, Eduardo M, Johansson, Jan, Macaulay, Graeme D, Wijnhoven, Bas PL, Benedix, Frank, Attwood, Stephen E, Hoelscher, Arnulf Heinrich, Priego, Pablo, Fuchs, Karl-Hermann, Luyer, Misha DP, Griffiths, Ewen A, Sovik, Torgeir Thorson, Theodorou, Dimitrios, Sgromo, Bruno, Salo, Jarmo A, Singhal, Rishi, Thorell, Anders, Zaninotto, Giovanni, Itenc, Marko, D'journo, Xavier Benoit, Fullarton, Grant M, Horbach, Thomas, Surgery, CCA - Cancer Treatment and Quality of Life, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and CCA - Cancer Treatment and quality of life

Subjects
REPAIR, MESH, Hiatus hernia, Mesh, Science & Technology, Fundoplication, Surgical technique, GUIDELINES, Paraesophageal hernia, REFLUX, Surgery, Delphi survey, RECURRENCE, Life Sciences & Biomedicine
Abstract

Aims There is considerable controversy regarding optimal management of patients with paraesophageal hiatus hernia (pHH). This survey aims at identifying recommended strategies for work-up, surgical therapy, and postoperative follow-up using Delphi methodology. Methods We conducted a 2-round, 33-question, web-based Delphi survey on perioperative management (preoperative work-up, surgical procedure and follow-up) of non-revisional, elective pHH among European surgeons with expertise in upper-GI. Responses were graded on a 5-point Likert scale and analyzed using descriptive statistics. Items from the questionnaire were defined as “recommended” or “discouraged” if positive or negative concordance among participants was > 75%. Items with lower concordance levels were labelled “acceptable” (neither recommended nor discouraged). Results Seventy-two surgeons with a median (IQR) experience of 23 (14–30) years from 17 European countries participated (response rate 60%). The annual median (IQR) individual and institutional caseload was 25 (15–36) and 40 (28–60) pHH-surgeries, respectively. After Delphi round 2, “recommended” strategies were defined for preoperative work-up (endoscopy), indication for surgery (typical symptoms and/or chronic anemia), surgical dissection (hernia sac dissection and resection, preservation of the vagal nerves, crural fascia and pleura, resection of retrocardial lipoma) and reconstruction (posterior crurorrhaphy with single stitches, lower esophageal sphincter augmentation (Nissen or Toupet), and postoperative follow-up (contrast radiography). In addition, we identified “discouraged” strategies for preoperative work-up (endosonography), and surgical reconstruction (crurorrhaphy with running sutures, tension-free hiatus repair with mesh only). In contrast, many items from the questionnaire including most details of mesh augmentation (indication, material, shape, placement, and fixation technique) were “acceptable”. Conclusions This multinational European Delphi survey represents the first expert-led process to identify recommended strategies for the management of pHH. Our work may be useful in clinical practice to guide the diagnostic process, increase procedural consistency and standardization, and to foster collaborative research.

Published
2023

40. Identification of Prognostic Phenotypes of Esophageal Adenocarcinoma in 2 Independent Cohorts

Author

Noorani, Ayesha, Edwards, Paul A.W., Grehan, Nicola, Nutzinger, Barbara, Hughes, Caitriona, Fidziukiewicz, Elwira, Bornschein, Jan, MacRae, Shona, Crawte, Jason, Contino, Gianmarco, Li, Xiaodun, Rue, Rachel de la, O’Donovan, Maria, Miremad, Ahmad, Malhotra, Shalini, Tripathi, Monika, Tavaré, Simon, Lynch, Andy G., Eldridge, Matthew, Secrier, Maria, Bower, Lawrence, Devonshire, Ginny, Perner, Juliane, Jammula, Sriganesh, Davies, Jim, Crichton, Charles, Carroll, Nick, Safranek, Peter, Hindmarsh, Andrew, Sujendran, Vijayendran, Hayes, Stephen J., Ang, Yeng, Preston, Shaun R., Oakes, Sarah, Bagwan, Izhar, Save, Vicki, Skipworth, Richard J.E., Hupp, Ted R., O’Neill, J. Robert, Tucker, Olga, Beggs, Andrew, Taniere, Philippe, Puig, Sonia, Underwood, Timothy J., Noble, Fergus, Owsley, Jack, Barr, Hugh, Shepherd, Neil, Old, Oliver, Lagergren, Jesper, Gossage, James, Davies, Andrew, Chang, Fuju, Zylstra, Janine, Mahadeva, Ula, Goh, Vicky, Ciccarelli, Francesca D., Sanders, Grant, Berrisford, Richard, Harden, Catherine, Bunting, David, Lewis, Mike, Cheong, Ed, Kumar, Bhaskar, Parsons, Simon L., Soomro, Irshad, Kaye, Philip, Saunders, John, Lovat, Laurence, Haidry, Rehan, Eneh, Victor, Igali, Laszlo, Scott, Michael, Sothi, Sharmila, Suortamo, Sari, Lishman, Suzy, Hanna, George B., Peters, Christopher J., Grabowska, Anna, Turkington, Richard, Sawas, Tarek, Killcoyne, Sarah, Iyer, Prasad G., Wang, Kenneth K., Smyrk, Thomas C., Kisiel, John B., Qin, Yi, Ahlquist, David A., Rustgi, Anil K., Costa, Rui J., Gerstung, Moritz, Fitzgerald, Rebecca C., and Katzka, David A.

Published
2018
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41. Erratum to “Practice variation in anastomotic leak after esophagectomy: Unravelling differences in failure to rescue” [Eur J Surg Oncol 49 (5) (May 2023) 974–982]

Author

Ubels, Sander, primary, Matthée, Eric, additional, Verstegen, Moniek, additional, Klarenbeek, Bastiaan, additional, Bouwense, Stefan, additional, van Berge Henegouwen, Mark I., additional, Daams, Freek, additional, Dekker, Jan Willem T., additional, van Det, Marc J., additional, van Esser, Stijn, additional, Griffiths, Ewen A., additional, Haveman, Jan Willem, additional, Nieuwenhuijzen, Grard, additional, Siersema, Peter D., additional, Wijnhoven, Bas, additional, Hannink, Gerjon, additional, van Workum, Frans, additional, Rosman, Camiel, additional, Heisterkamp, Joos, additional, Polat, Fatih, additional, Schouten, Jeroen, additional, Singh, Pritam, additional, Slootmans, Cettela A.M., additional, Ultee, Gijs, additional, Gisbertz, Suzanne S., additional, Eshuis, Wietse J., additional, Kalff, Marianne C., additional, Feenstra, Minke L., additional, van der Peet, Donald L., additional, Stam, Wessel T., additional, Van Etten, Boudewijn, additional, Poelmann, Floris, additional, Vuurberg, Nienke, additional, Willem van den Berg, Jan, additional, Martijnse, Ingrid S., additional, Matthijsen, Robert M., additional, Luyer, Misha, additional, Curvers, Wout, additional, Nieuwenhuijzen, Tom, additional, Taselaar, Annick E., additional, Kouwenhoven, Ewout A., additional, Lubbers, Merel, additional, Sosef, Meindert, additional, Lecot, Frederik, additional, Geraedts, Tessa C.M., additional, van den Wildenberg, Frits, additional, Kelder, Wendy, additional, Baas, Peter C., additional, de Haas, Job W.A., additional, Hartgrink, Henk H., additional, Bahadoer, Renu R., additional, van Sandick, Johanna W., additional, Hartemink, Koen J., additional, Veenhof, Xander, additional, Stockmann, Hein, additional, Gorgec, Burak, additional, Weeder, Pepijn, additional, Wiezer, Marinus J., additional, Genders, Charlotte M.S., additional, Belt, Eric, additional, Blomberg, Bjorn, additional, van Duijvendijk, Peter, additional, Claassen, Linda, additional, Reetz, David, additional, Steenvoorde, Pascal, additional, Mastboom, Walter, additional, Klein Ganseij, Henk Jan, additional, van Dalsen, Annette D., additional, Joldersma, Annalie, additional, Zwakman, Marije, additional, Groenendijk, Richard P.R., additional, Montazeri, Mahsa, additional, Mercer, Stuart, additional, Knight, Benjamin, additional, van Boxel, Gijs, additional, McGregor, Richard J., additional, Skipworth, Richard J.E., additional, Frattini, Cristina, additional, Bradley, Alice, additional, Nilsson, Magnus, additional, Hayami, Masaru, additional, Huang, Biying, additional, Bundred, James, additional, Evans, Richard, additional, Grimminger, Peter P., additional, van der Sluis, Pieter C., additional, Eren, Uzun, additional, Saunders, John, additional, Theophilidou, Elena, additional, Khanzada, Zubair, additional, Elliott, Jessie A., additional, Ponten, Jeroen, additional, King, Sinead, additional, Reynolds, John V., additional, Sgromo, Bruno, additional, Akbari, Khalid, additional, Shalaby, Samar, additional, Gutschow, Christian A., additional, Schmidt, Henner, additional, Vetter, Diana, additional, Moorthy, Krishna, additional, Ibrahim, Mohamed A.H., additional, Christodoulidis, Grigorious, additional, Räsänen, Jari V., additional, Kauppi, Juha, additional, Söderström, Henna, additional, Koshy, Renol, additional, Manatakis, Dimitrios K., additional, Korkolis, Dimitrios P., additional, Balalis, Dimitrios, additional, Rompu, Aliki, additional, Alkhaffaf, Bilal, additional, Alasmar, Mohamed, additional, Arebi, Moaad, additional, Piessen, Guillaume, additional, Nuytens, Frederiek, additional, Degisors, Sebastien, additional, Ahmed, Ahmed, additional, Boddy, Alex, additional, Gandhi, Suraj, additional, Fashina, Oluwatomini, additional, Van Daele, Elke, additional, Pattyn, Piet, additional, Robb, William B., additional, Arumugasamy, Mayilone, additional, Al Azzawi, Mohammed, additional, Whooley, Jack, additional, Colak, Elif, additional, Aybar, Engin, additional, Sari, Ahmet C., additional, Uyanik, Mustafa S., additional, Ciftci, Ahmet B., additional, Sayyed, Raza, additional, Ayub, Bushra, additional, Murtaza, Ghulam, additional, Saeed, Aniqa, additional, Ramesh, Priyanka, additional, Charalabopoulos, Alexandros, additional, Liakakos, Theodore, additional, Schizas, Dimitrios, additional, Baili, Efstratia, additional, Kapelouzou, Alkistis, additional, Valmasoni, Michele, additional, Pierobon, Elisa Sefora, additional, Capovilla, Giovanni, additional, Merigliano, Stefano, additional, Constantinoiu, Silviu, additional, Birla, Rodica, additional, Achim, Florin, additional, Rosianu, Cristian Gelu, additional, Hoara, Petre, additional, Castro, Raúl Guevara, additional, Salcedo, Andrés Felipe, additional, Negoi, Ionut, additional, Negoita, Valentina M., additional, Ciubotaru, Cezar, additional, Stoica, Bogdan, additional, Hostiuc, Sorin, additional, Colucci, Nicola, additional, Mönig, Stefan P., additional, Wassmer, Charles-Henri, additional, Meyer, Jeremy, additional, Takeda, Flavio Roberto, additional, Aissar Sallum, Rubens Antonio, additional, Ribeiro, Ulysses, additional, Cecconello, Ivan, additional, Toledo, Enrique, additional, Trugeda, Maria Soledad, additional, Fernández, María José, additional, Gil, Carolina, additional, Castanedo, Sonia, additional, Isik, Arda, additional, Kurnaz, Eray, additional, Videira, José Flávio, additional, Peyroteo, Mariana, additional, Canotilho, Rita, additional, Weindelmayer, Jacopo, additional, Giacopuzzi, Simone, additional, De Pasqual, Carlo Alberto, additional, Bruna, Marcos, additional, Mingol, Fernando, additional, Vaque, Javier, additional, Pérez, Carla, additional, Phillips, Alexander W., additional, Chmelo, Jakub, additional, Brown, Joshua, additional, Han, Laura E., additional, Gossage, James A., additional, Davies, Andrew R., additional, Baker, Cara R., additional, Kelly, Mark, additional, Saad, Mohamed, additional, Bernardi, Daniele, additional, Bonavina, Luigi, additional, Asti, Emanuele, additional, Riva, Carlo, additional, Scaramuzzo, Rosa, additional, Elhadi, Muhammed, additional, Ahmed, Hazem Abdelkarem, additional, Elhadi, Ahmed, additional, Elnagar, Faruk Ali, additional, Msherghi, Ahmed A.A., additional, Wills, Vanessa, additional, Campbell, Cassidy, additional, Cerdeira, Marisol Perez, additional, Whiting, Scott, additional, Merrett, Neil, additional, Das, Amitabha, additional, Apostolou, Christos, additional, Lorenzo, Aldenb, additional, Sousa, Fabiana, additional, Barbosa, José Adelino, additional, Devezas, Vítor, additional, Barbosa, Elisabete, additional, Fernandes, Cristina, additional, Smith, Garett, additional, Li, Edward Y., additional, Bhimani, Nazim, additional, Chan, Priscilla, additional, Kotecha, Krishna, additional, Hii, Michael W., additional, Ward, Salena M., additional, Johnson, MaryAnn, additional, Read, Matthew, additional, Chong, Lynn, additional, Hollands, Michael J., additional, Allaway, Matthew, additional, Richardson, Arthur, additional, Johnston, Emma, additional, Chen, Andy Z.L., additional, Kanhere, Harsh, additional, Prasad, Shalvin, additional, McQuillan, Patrick, additional, Surman, Tim, additional, Trochsler, MarkusI., additional, Schofield, W.A., additional, Ahmed, Syeda Khadijah, additional, Reid, Jessica L., additional, Harris, Mark C., additional, Gananadha, Sivakumar, additional, Farrant, Jessica, additional, Rodrigues, Nicole, additional, Fergusson, James, additional, Hindmarsh, Andrew, additional, Afzal, Zeeshan, additional, Safranek, Peter, additional, Sujendran, Vijay, additional, Rooney, Siobhan, additional, Loureiro, Carlos, additional, Fernández, Saioa Leturio, additional, Díez del Val, Ismael, additional, Jaunoo, Shameen, additional, Kennedy, Lauren, additional, Hussain, Ahmed, additional, Theodorou, Dimitrios, additional, Triantafyllou, Tania, additional, Theodoropoulos, Charalampos, additional, Palyvou, Theodora, additional, Ben Taher, Fatima Abdullah, additional, and Ekheel, Mustafa, additional

Published
2023
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42. Prehabilitation exercise before oesophagectomy: long-term follow-up of patients declining/withdrawing from the program

Author

Knight, William, primary, Moore, Jonathan L, additional, Whyte, Greg P, additional, Zylstra, Janine, additional, Lane, Andrew M, additional, Pate, James, additional, Gervais-Andre, Louise, additional, Maisey, Nick, additional, Hill, Mark, additional, Tham, Gemma, additional, Lagergren, Jesper, additional, Kelly, Mark, additional, Baker, Cara, additional, Van Hemelrijck, Mieke, additional, Goh, Vicky, additional, Gossage, James, additional, Browning, Mike, additional, and Davies, Andrew R, additional

Published
2023
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44. Brain arteriovenous malformations associated with hereditary hemorrhagic telangiectasia: Gene–phenotype correlations

Author

Nishida, Takeo, Faughnan, Marie E, Krings, Timo, Chakinala, Murali, Gossage, James R, Young, William L, Kim, Helen, Pourmohamad, Tony, Henderson, Katharine J, Schrum, Stacy D, James, Melissa, Quinnine, Nancy, Bharatha, Aditya, terBrugge, Karel G, and White, Robert I

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Congenital Structural Anomalies, Hematology, Pediatric, Brain Disorders, Neurosciences, Stroke, Clinical Research, Rare Diseases, Activin Receptors, Type II, Adolescent, Adult, Aged, Antigens, CD, Arteriovenous Fistula, Child, Child, Preschool, Endoglin, Female, Genetic Association Studies, Humans, Infant, Infant, Newborn, Intracellular Signaling Peptides and Proteins, Intracranial Arteriovenous Malformations, Male, Middle Aged, Mutation, Receptors, Cell Surface, Smad4 Protein, Telangiectasia, Hereditary Hemorrhagic, Young Adult, hereditary hemorrhagic telangiectasia, brain arteriovenous malformation, genotype, intracranial hemorrhage, Clinical Sciences, Clinical sciences
Abstract

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant genetic disease with a wide spectrum of vascular malformations (VMs) involving multiple organs. Nine to 16% of patients with HHT harbor brain arteriovenous malformations (AVMs), which can cause intracranial hemorrhage (ICH). Our objective was to study clinical manifestations of brain AVMs in patients with HHT and correlate these with the specific gene mutated. We reviewed records of 171 patients with HHT and brain AVMs. A history of ICH was found in 27% (41/152) patients, with a mean age of 26 ± 18 range, (0-68) years. All of patients with ICH were neurologically asymptomatic prior to ICH. Multiple brain AVMs were found in 23% (170/39) of patients on initial examination. Genetic test results were available in 109 (64%) patients. Mutations in ENG, ACVRL1, and SMAD4 were present in 75 (69%), 18 (17%), and 2 (2%), respectively. A history of ICH was reported in 24% of patients with an ENG mutation and 27% of patients with an ACVRL1 mutation, with a mean age of 26 ± 16 (range, 2-50) and 18 ± 21 (0-48) years, respectively. No statistically significant differences in age at first brain AVM diagnosis, prevalence of ICH history, age at ICH, or other manifestations of brain AVMs were observed among gene groups. In conclusion, no evidence for differences in brain AVM characteristics was observed among HHT gene groups, although we cannot exclude clinically important differences. Larger studies are needed to further guide brain AVM screening decisions in patients with HHT.

Published
2012

45. Extended Wireless pH Monitoring Significantly Increases Gastroesophageal Reflux Disease Diagnoses in Patients With a Normal pH Impedance Study

Author

Zeki, Sebastian S, primary, Miah, Ismail, additional, Visaggi, Pierfrancesco, additional, Wolak, Anna, additional, deSilva, Minerva, additional, Dunn, Jason M, additional, Davies, Andrew, additional, Gossage, James, additional, Botha, Abrie, additional, Sui, Guiping, additional, Jafari, Jafar, additional, and Wong, Terry, additional

Published
2023
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46. Long Term Survival of Heritable Pulmonary Arterial Hypertension Associated with Hereditary Hemorrhagic Telangiectasia: A Case Series.

Author

Jamindar, Parth, Pope, Michael, and Gossage, James

Subjects
HEREDITARY hemorrhagic telangiectasia, PULMONARY arterial hypertension, GENETIC disorders, ARTERIOVENOUS malformation, PULMONARY hypertension, TELANGIECTASIA
Abstract

Hereditary hemorrhagic telangiectasia (HHT) is a hereditary disease characterized by recurrent epistaxis, mucocutaneous telangiectasias, and visceral arteriovenous malformations. Multiple genetic mutations have been linked to this rare disease, including ENG, ALK1 (ACVRL1), and MADH4. Pulmonary hypertension is a potential complication of HHT, with the most common phenotypes being World Health Organization (WHO) group 1 heritable pulmonary arterial hypertension (PAH), which is typically associated with ALK1 mutation; WHO group 2 pulmonary hypertension due to high output heart failure from hepatic arteriovenous malformations and/or anemia; and WHO group 2 due to high pulmonary artery wedge pressure. There is scarce evidence to help guide treatment of heritable PAH in HHT, and observational literature suggests that patients with HHT and heritable PAH have a worse prognosis compared to patients with idiopathic PAH. We describe the diagnosis, pulmonary hemodynamics, and detailed treatment courses of three patients with ALK1-associated HHT and PAH, who all exhibited objective clinical improvement with parenteral prostacyclins and oral agents. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Preoperative risk factors for conversion from laparoscopic to open cholecystectomy: a validated risk score derived from a prospective U.K. database of 8820 patients

Author

Fenwick, Stephen, Elmasry, Mohamed, Nunes, Quentin, Kennedy, David, Khan, Raja B., Khan, Muhammad A.S., Magee, Conor J., Jones, Steven M., Mason, Denise, Parappally, Ciny P., Mathur, Pawan, Saunders, Michael, Jamel, Sara, Haque, Samer U.l., Zafar, Sara, Shiwani, Muhammad H., Samuel, Nehemiah, Dar, Farooq, Jackson, Andrew, Lovett, Bryony, Dindyal, Shiva, Winter, Hannah, Rahman, Saquib, Wheatley, Kevin, Nieto, Tom, Ayaani, Soofiyah, Youssef, Haney, Nijjar, Rajwinder S., Watkin, Helen, Naumann, David, Emeshi, Sophie, Sarmah, Piyush B., Lee, Kathryn, Joji, Nikita, Heath, Jonathan, Teasdale, Rebecca L., Weerasinghe, Chamindri, Needham, Paul J., Welbourn, Hannah, Forster, Luke, Finch, David, Blazeby, Jane M., Robb, William, McNair, Angus G.K., Hrycaiczuk, Alex, Charalabopoulos, Alexandros, Kadirkamanathan, Sritharan, Tang, Cheuk-Bong, Jayanthi, Naga V.G., Noor, Nigel, Dobbins, Brian, Cockbain, Andrew J., Nilsen-Nunn, April, de Siqueira, Jonathan, Pellen, Mike, Cowley, Jonathan B., Ho, Wei-Min, Miu, Victor, White, Timothy J., Hodgkins, Kathryn A., Kinghorn, Alison, Tutton, Matthew G., Al-Abed, Yahya A., Menzies, Donald, Ahmad, Anwar, Reed, Joanna, Khan, Shabuddin, Monk, David, Vitone, Louis J., Murtaza, Ghulam, Joel, Abraham, Brennan, Stephen, Shier, David, Zhang, Catherine, Yoganathan, Thusidaran, Robinson, Steven J., McCallum, Iain J.D., Jones, Michael J., Elsayed, Mohammed, Tuck, Liz, Wayman, John, Carney, Kate, Aroori, Somaiah, Hosie, Kenneth B., Kimble, Adam, Bunting, David M., Fawole, Adeshina S., Basheer, Mohammed, Dave, Rajiv V., Sarveswaran, Janahan, Jones, Elinor, Kendal, Chris, Tilston, Michael P., Gough, Martin, Wallace, Tom, Singh, Shailendra, Downing, Justine, Mockford, Katherine A., Issa, Eyad, Shah, Nayab, Chauhan, Neal, Wilson, Timothy R., Forouzanfar, Amir, Wild, Jonathan R.L., Nofal, Emma, Bunnell, Catherine, Madbak, Khaliel, Rao, Sudhindra T.V., Devoto, Laurence, Siddiqi, Najaf, Khawaja, Zechan, Hewes, James C., Gould, Laura, Chambers, Alice, Rodriguez, Daniel U., Sen, Gourab, Robinson, Stuart, Bartlett, Francis, Rae, David M., Stevenson, Thomas E.J., Sarvananthan, Kas, Dwerryhouse, Simon J., Higgs, Simon M., Old, Oliver J., Hardy, Thomas J., Shah, Reena, Hornby, Steve T., Keogh, Ken, Frank, Lucinda, Al-Akash, Musallam, Upchurch, Emma A., Frame, Richard J., Hughes, Michael, Jelley, Clare, Weaver, Simon, Roy, Sudipta, Sillo, Toritseju O., Galanopoulos, Giorgios, Cuming, Tamzin, Cunha, Pedro, Tayeh, Salim, Kaptanis, Sarantos, Heshaishi, Mohamed, Eisawi, Abdalla, Abayomi, Michael, Ngu, Wee S., Fleming, Katie, Bajwa, Dalvir S., Chitre, Vivek, Aryal, Kamal, Ferris, Paul, Silva, Michael, Lammy, Simon, Mohamed, Sarah, Khawaja, Amir, Hussain, Adnan, Ghazanfar, Mudassar A., Bellini, Maria I., Ebdewi, Hamdi, Elshaer, Mohamed, Gravante, Gianpiero, Drake, Benjamin, Ogedegbe, Arikoge, Mukherjee, Dipankar, Arhi, Chanpreet, Giwa, Lola, Iqbal, Nusrat, Watson, Nicholas F., Aggarwal, Smeer K., Orchard, Philippa, Villatoro, Eduardo, Willson, Peter D., Mok, Kam W.J., Woodman, Thomas, Deguara, Jean, Garcea, Giuseppe, Babu, Benoy I., Dennison, Alistair R., Malde, Deep, Lloyd, David, Slavin, John P., Jones, Robert P., Ballance, Laura, Gerakopoulos, Stratos, Jambulingam, Periyathambi, Mansour, Sami, Sakai, Naomi, Acharya, Vikas, Sadat, Mohammed M., Karim, Lawen, Larkin, David, Amin, Khalid, Khan, Amarah, Law, Jennifer, Jamdar, Saurabh, Smith, Stella R., Sampat, Keerthika, O'shea, Kathryn M., Manu, Mangta, Asprou, Fotini M., Malik, Nabeela S., Chang, Jessica, Johnstone, Marianne, Lewis, Michael, Roberts, Geoffrey P., Karavadra, Babu, Photi, Evangelos, Hewes, James, Rodriguez, Dan, O'Reilly, Derek A., Rate, Anthony J., Sekhar, Hema, Henderson, Lucy T., Starmer, Benjamin Z., Coe, Peter O., Tolofari, Sotonye, Barrie, Jenifer, Bashir, Gareth, Sloane, Jake, Madanipour, Suroosh, Halkias, Constantine, Trevatt, Alexander E.J., Borowski, David W., Hornsby, Jane, Courtney, Michael J., Virupaksha, Suvi, Seymour, Keith, Robinson, Sarah, Hawkins, Helen, Bawa, Sadiq, Gallagher, Paul V., Reid, Alistair, Wood, Peter, Finch, Jonathan G., Finch, J.Guy, Parmar, Jitesh, Stirland, Euan, Gardner-Thorpe, James, Al-Muhktar, Ahmed, Peterson, Mark, Majeed, Ali, Bajwa, Farrukh M., Martin, Jack, Choy, Alfred, Tsang, Andrew, Pore, Naresh, Andrew, David R., Al-Khyatt, Waleed, Santosh Bhandari, Christopher Taylor, Chambers, Adam, Subramanium, Dhivya, Toh, Simon K.C., Carter, Nicholas C., Mercer, Stuart J., Knight, Benjamin, Vijay, Vardhini, Alagaratnam, Swethan, Sinha, Sidhartha, Khan, Shahab, El-Hasani, Shamsi S., Hussain, Abdulzahra A., Bhattacharya, Vish, Kansal, Nisheeth, Fasih, Tani, Jackson, Claire, Siddiqui, Midhat N., Chishti, Imran A., Fordham, Imogen J., Siddiqui, Zohaib, Bausbacher, Harald, Geogloma, Ileana, Gurung, Kabita, Tsavellas, George, Basynat, Pradeep, Shrestha, Ashish K., Basu, Sanjoy, Chhabra, Alok, Harilingam, Mohan, Rabie, Mohamed, Akhtar, Mansoor, Kumar, Pradeep, Jafferbhoy, Sadaf F., Hussain, Najam, Raza, Soulat, Haque, Manzarul, Alam, Imran, Aseem, Rabiya, Patel, Shakira, Asad, Mehek, Booth, Michael I., Ball, William R., Wood, Christopher P.J., Pinho-Gomes, Ana C., Kausar, Ambareen, Obeidallah, Mohammed, Varghase, Joseph, Lodhia, Joshil, Bradley, Donal, Rengifo, Carla, Lindsay, David, Gopalswamy, Sivakumar, Finlay, Ian, Wardle, Stacy, Bullen, Naomi, Iftikhar, Syed Y., Awan, Altaf, Ahmed, Javed, Leeder, Paul, Fusai, Guiseppe, Bond-Smith, Giles, Psica, Alicja, Puri, Yogesh, Hou, David, Noble, Fergus, Szentpali, Karoly, Broadhurst, Jack, Date, Ravindra, Hossack, Martin R., Goh, Yan L., Turner, Paul, Shetty, Vinutha, Riera, Manel, Macano, Christina A.W., Sukha, Anisha, Preston, Shaun R., Hoban, Jennifer R., Puntis, Daniel J., Williams, Sophie V., Krysztopik, Richard, Kynaston, James, Batt, Jeremy, Doe, Matthew, Goscimski, Andrzej, Jones, Gareth H., Hall, Claire, Carty, Nick, Ahmed, Jamil, Panteleimonitis, Sofoklis, Gunasekera, Rohan T., Sheel, Andrea R.G., Lennon, Hannah, Hindley, Caroline, Reddy, Marcus, Kenny, Ross, Elkheir, Natalie, McGlone, Emma R., Rajaganeshan, Rajasundaram, Hancorn, Kate, Hargreaves, Anita, Prasad, Raj, Longbotham, David A., Vijayanand, Dhakshinamoorthy, Wijetunga, Imeshi, Ziprin, Paul, Nicolay, Christopher R., Yeldham, Geoffrey, Read, Edward, Gossage, James A., Rolph, Rachel C., Ebied, Husam, Phull, Manraj, Khan, Mohammad A., Popplewell, Matthew, Kyriakidis, Dimitrios, Hussain, Anwar, Henley, Natasha, Packer, Jessica R., Derbyshire, Laura, Porter, Jonathan, Appleton, Shaun, Farouk, Marwan, Basra, Melvinder, Jennings, Neil A., Ali, Shahda, Kanakala, Venkatesh, Ali, Haythem, Lane, Risha, Dickson-Lowe, Richard, Zarsadias, Prizzi, Mirza, Darius, Puig, Sonia, Al Amari, Khalid, Vijayan, Deepak, Sutcliffe, Robert, Marudanayagam, Ravi, Hamady, Zayed, Prasad, Abheesh R., Patel, Abhilasha, Durkin, Damien, Kaur, Parminder, Bowen, Laura, Byrne, James P., Pearson, Katherine L., Delisle, Theo G., Davies, James, Tomlinson, Mark A., Johnpulle, Michelle A., Slawinski, Corinna, Macdonald, Andrew, Nicholson, James, Newton, Katy, Mbuvi, James, Farooq, Ansar, Mothe, Bhavani S., Zafrani, Zakhi, Brett, Daniel, Francombe, James, Spreadborough, Philip, Barnes, James, Cheung, Melanie, Al-Bahrani, Ahmed Z., Preziosi, Giuseppe, Urbonas, Tomas, Alberts, Justin, Mallik, Mekhlola, Patel, Krashna, Segaran, Ashvina, Doulias, Triantafyllos, Sufi, Pratik A., Yao, Caroline, Pollock, Sarah, Manzelli, Antonio, Wajed, Saj, Kourkulos, Michail, Pezzuto, Roberto, Wadley, Martin, Hamilton, Emma, Jaunoo, Shameen, Padwick, Robert, Sayegh, Mazin, Newton, Richard C., Hebbar, Madhusoodhana, Farag, Sameh F., Hebbar, Madhu, Spearman, John, Hamdan, Mohammed F., D'Costa, Conrad, Blane, Christine, Giles, Mathew, Peter, Mark B., Hirst, Natalie A., Hossain, Tanvir, Pannu, Arslan, El-Dhuwaib, Yesar, Morrison, Tamsin E.M., Taylor, Greg W., Thompson, Ronald L.E., McCune, Ken, Loughlin, Paula, Lawther, Roger, Byrnes, Colman K., Simpson, Duncan J., Mawhinney, Abi, Warren, Conor, McKay, Damian, McIlmunn, Colin, Martin, Serena, MacArtney, Matthew, Diamond, Tom, Davey, Phil, Jones, Claire, Clements, Joshua M., Digney, Ruairi, Chan, Wei M., McCain, Stephen, Gull, Sadaf, Janeczko, Adam, Dorrian, Emmet, Harris, Andrew, Dawson, Suzanne, Johnston, Dorothy, McAree, Barry, Ghareeb, Essam, Thomas, George, Connelly, Martin, McKenzie, Stephen, Cieplucha, Krzysztos, Spence, Gary, Campbell, William, Hooks, Gareth, Bradley, Neil, Hill, Arnold D.K., Cassidy, John T., Boland, Michael, Burke, Paul, Nally, Deirdre M., Khogali, Elmoataz, Shabo, Wael, Iskandar, Edrin, McEntee, Gerry P., O'Neill, Maeve A., Peirce, Colin, Lyons, Emma M., O'Sullivan, Adrian W., Thakkar, Rohan, Carroll, Paul, Ivanovski, Ivan, Balfe, Paul, Lee, Matthew, Winter, Des C., Kelly, Michael E., Hoti, Emir, Maguire, Donal, Karunakaran, Priyadarssini, Geoghegan, Justin G., Martin, Sean T., Cross, Keith S., Cooke, Fiachra, Zeeshan, Saquib, Murphy, James O., Mealy, Ken, Mohan, Helen M., Nedujchelyn, 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Published
2016
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50. Management of paraesophageal hiatus hernia:recommendations following a European expert Delphi consensus

Author

Gerdes, Stephan, Schoppmann, Sebastian F., Bonavina, Luigi, Boyle, Nicholas, Müller-Stich, Beat P., Gutschow, Christian A., Gisbertz, Suzanne Sarah, Köckerling, Ferdinand, Lehmann, Thorsten G., Lorenz, Dietmar, Granderath, Frank Alexander, Rosati, Riccardo, Wullstein, Christoph, Lundell, Lars, Cheong, Edward, Nafteux, Philippe, Olmi, Stefano, Mönig, Stefan, Biebl, Matthias, Leers, Jessica, Zehetner, Joerg, Kristo, Ivan, Berrisford, Richard George, Skrobić, Ognjan M., Simić, Aleksandar P., Pera, Manuel, Grimminger, Peter Philipp, Gockel, Ines, Zarras, Konstantinos, Nieuwenhuijs, Vincent Bernard, Gossage, James A., van Berge Henegouwen, Mark i., Stein, Hubert J., Markar, Sheraz R., Hueting, Willem Eduard, Targarona, Eduardo M., Johansson, Jan, Macaulay, Graeme D., Wijnhoven, Bas P.L., Benedix, Frank, Attwood, Stephen E., Hölscher, Arnulf Heinrich, Priego, Pablo, Fuchs, Karl Hermann, Luyer, Misha D.P., Griffiths, Ewen A., Søvik, Torgeir Thorson, Theodorou, Dimitrios, Sgromo, Bruno, Salo, Jarmo A., Gerdes, Stephan, Schoppmann, Sebastian F., Bonavina, Luigi, Boyle, Nicholas, Müller-Stich, Beat P., Gutschow, Christian A., Gisbertz, Suzanne Sarah, Köckerling, Ferdinand, Lehmann, Thorsten G., Lorenz, Dietmar, Granderath, Frank Alexander, Rosati, Riccardo, Wullstein, Christoph, Lundell, Lars, Cheong, Edward, Nafteux, Philippe, Olmi, Stefano, Mönig, Stefan, Biebl, Matthias, Leers, Jessica, Zehetner, Joerg, Kristo, Ivan, Berrisford, Richard George, Skrobić, Ognjan M., Simić, Aleksandar P., Pera, Manuel, Grimminger, Peter Philipp, Gockel, Ines, Zarras, Konstantinos, Nieuwenhuijs, Vincent Bernard, Gossage, James A., van Berge Henegouwen, Mark i., Stein, Hubert J., Markar, Sheraz R., Hueting, Willem Eduard, Targarona, Eduardo M., Johansson, Jan, Macaulay, Graeme D., Wijnhoven, Bas P.L., Benedix, Frank, Attwood, Stephen E., Hölscher, Arnulf Heinrich, Priego, Pablo, Fuchs, Karl Hermann, Luyer, Misha D.P., Griffiths, Ewen A., Søvik, Torgeir Thorson, Theodorou, Dimitrios, Sgromo, Bruno, and Salo, Jarmo A.

Abstract

Aims: There is considerable controversy regarding optimal management of patients with paraesophageal hiatus hernia (pHH). This survey aims at identifying recommended strategies for work-up, surgical therapy, and postoperative follow-up using Delphi methodology. Methods: We conducted a 2-round, 33-question, web-based Delphi survey on perioperative management (preoperative work-up, surgical procedure and follow-up) of non-revisional, elective pHH among European surgeons with expertise in upper-GI. Responses were graded on a 5-point Likert scale and analyzed using descriptive statistics. Items from the questionnaire were defined as “recommended” or “discouraged” if positive or negative concordance among participants was > 75%. Items with lower concordance levels were labelled “acceptable” (neither recommended nor discouraged). Results: Seventy-two surgeons with a median (IQR) experience of 23 (14–30) years from 17 European countries participated (response rate 60%). The annual median (IQR) individual and institutional caseload was 25 (15–36) and 40 (28–60) pHH-surgeries, respectively. After Delphi round 2, “recommended” strategies were defined for preoperative work-up (endoscopy), indication for surgery (typical symptoms and/or chronic anemia), surgical dissection (hernia sac dissection and resection, preservation of the vagal nerves, crural fascia and pleura, resection of retrocardial lipoma) and reconstruction (posterior crurorrhaphy with single stitches, lower esophageal sphincter augmentation (Nissen or Toupet), and postoperative follow-up (contrast radiography). In addition, we identified “discouraged” strategies for preoperative work-up (endosonography), and surgical reconstruction (crurorrhaphy with running sutures, tension-free hiatus repair with mesh only). In contrast, many items from the questionnaire including most details of mesh augmentation (indication, material, shape, placement, and fixation technique) were “acceptable”. Conclusions: This multina

Published
2023

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