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At a temperature of 110 ° C, the concentration of alpha-acid reaches 67.5%, beta-acid - 59%, which reduces the consumer properties of hops. The aim of the study is to develop a microwave convective hop dry-er, which provides a process flow rate of less than 0.5 to equalize the mois-ture content of hops in the structure during transportation through a toroi-dal resonator. We used the programs CST Microwave Studio 2018, Com-pass 3D V20. The hop dryer contains two truncated conical and toroidal resonators. In the central cylinder of the toroidal resonator there is no EMPSWH, here the moisture in the hop cones is equalized. In the capacitor part of the resonator, the electric field strength is sufficient to reduce the bacterial contamination of hops. A dielectric grid electric drive conveyor and a perforated ceramic trough are laid along all resonators. The techno-logical scheme of the process provides for determining the amount of evaporated moisture from each resonator, air flow, and the required power of heat guns. The electrical circuit provides control of three magnetrons and a conveyor. The expected specific heat consumption is 3.54 MJ/kg. The total air consumption is 300 m3/h, with a hop dryer capacity of 100 kg/h.

In the present article methodological and practical aspects of improvement of activity of the logistic operator of warehouse services on the basis of use of a process approach in management of the organization are considered. The object of the research is justification of necessity of process approach’s in logistic operation’s activity and development of algorithm of their work at clients’ business processes and approbation of assessment technique of logistics service efficiency. Scientific novelty of this article is that it is the first time when models of business processes of warehouse logistics one developed. Also algorithmization and standartization are carried out and indicators of an assessment of efficiency of rendered logistic service are developed. Use of process approach in logistics operator activity gives him powerful advantages in competitive rivalry. The increase of efficiency of logistic operator’s commercial activity (LLC Company «Logy Log» Nizhny Novgorod) after the transition in management from functions to processes fully confirms this statement. Consolidation of logistic operator’s positions in different functional areas becomes an incentive to development of logistics and as a result to reduction of costs at delivery of industrial freights and consumer goods to the final user.

Type 2 diabetes mellitus develops due to a combination of genetic and environmental factors. C57BL/6 mice prone to obesity and leptin resistance were kept on a high-fat diet for 21 weeks. The animals showed a significant increase in fasting and postprandial glucose levels and body weight, the development of insulin resistance, and by week 18, an increase in the serum TNFα level. Metformin therapy at a dose of 250 mg/kg was effective against the background of disturbances in carbohydrate metabolism: animals showed a significant decrease in insulin resistance and TNFα level., (© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)

The aim of the study was to investigate the effect of AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) on the consequences of metabolic syndrome and type 2 diabetes induced by the consumption of a high-fat diet (HFD) in male C57Bl/6 mice. Additionally, the animals from group 6 were administered Methotrexate (MTX) at a dose of 1 mg/kg in parallel with AICAR, which slows down the metabolism of AICAR. The animals were recorded with signs of metabolic syndrome and type 2 diabetes mellitus by recording their body weights, glucose and insulin levels, and the calculating HOMA-IRs. At the end of the study, at the end of the 13th week, during necropsy, the internal organs were assessed, the masses of the organs were recorded, and special attention was paid to visceral fat, assessing its amount and the mass of the fat surrounding epididymis. The biochemical parameters and histology of the internal organs and tissues were assessed. The animals showed signs of metabolic syndrome and type 2 diabetes, namely, weight gain, hyperglycemia, hyperinsulinemia, an increase in the amount and mass of abdominal fat, and metabolic disorders, all expressed in a pathological change in biochemical parameters and pathological changes in internal organs. The AICAR treatment led to a decrease in body weight, a decrease in the amount and mass of abdominal fat, and an improvement in the pathomorphological picture of internal organs. However, some hepatotoxic effects were observed when the animals, on a received standard diet (STD), were treated with AICAR starting from the first day of the study. The additional administration of MTX, an AICAR metabolic inhibitor, did not improve its efficacy. Thus, AICAR has therapeutic potential for the treatment of metabolic syndrome and type 2 diabetes.

The development of new herbal preparations for the treatment of urolithiasis is an urgent task of medical science. Ficus have attracted the attention of pharmacologists due to a wide range of biological properties, including antioxidant, anti-inflammatory, antibacterial and antifungal activity. We studied the effectiveness of Ficus tikoua Bur. in SD rats in which urolithiasis was induced by 6 weeks of oral administration of ethylene glycol 0.5% ad libitum instead of drinking water. Administration of the extract of Ficus tikoua Bur., as well as comparative drug Cystone ® after modeling of urolithiasis lead to the restoration of diuresis and the concentration of inorganic phosphates starting from the 6th week of the experiment. The use of the Ficus tikoua Bur. extract for 6 weeks, both during the modeling of urolithiasis and during the recovery period, led to the restoration of the percentage of lymphocytes in the blood, content of sodium, chlorine and inorganic phosphates in the blood to the control level. Thus, the extract of Ficus tikoua Bur. seems to be a promising drug for effective treatment of the initial stages of the development of urolithiasis., Competing Interests: Author PW is employed by Chengdu SinoPharmTech Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Bervinova, Palikov, Mikhailov, Palikova, Borozdina, Kazakov, Rudenko, Tukhovskaya, Dyachenko, Slashcheva, Goryacheva, Sadovnikova, Kravchenko, Kalabina, Shinelev, Wu and Murashev.)