1. Pharmacokinetic disposition of 14C-glyburide in patients with varying renal function.
- Author
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Pearson JG, Antal EJ, Raehl CL, Gorsch HK, Craig WA, Albert KS, and Welling PG
- Subjects
- Absorption, Administration, Oral, Adult, Aged, Breath Tests, Carbon Radioisotopes, Chromatography, High Pressure Liquid, Creatinine analysis, Feces analysis, Glyburide blood, Glyburide urine, Humans, Kidney metabolism, Kinetics, Male, Middle Aged, Glyburide metabolism, Kidney Diseases metabolism
- Abstract
The pharmacokinetics of 14C-labeled glyburide were studied in 13 men with varying degrees of renal impairment. Patients received a single, 5 mg oral dose of glyburide as a solution (10 microCi/ml/mg) after a high-carbohydrate breakfast. Serial plasma and breath samples were collected for 48 hours and urine and feces were collected for 5 to 7 days. Patients with normal to moderately impaired renal function (creatinine clearance [CLCR] of 29 to 131 ml/min/1.7 m2) had glyburide plasma t1/2 values of 2.0 to 5.0 hours, with no relationship between CLCR and glyburide clearance. One subject with severe renal impairment (CLCR = 5 ml/min/1.7 m2) had decreased glyburide clearance that resulted in a t1/2 of 11 hours. The elimination of metabolites was more dependent on renal status but was only significantly affected in the patient with severe renal impairment.
- Published
- 1986
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