43 results on '"Gorostidi F"'
Search Results
2. Tratamiento de las estenosis laríngeas y traqueales del adulto
- Author
-
Lagier, A., Gorostidi, F., Demez, P., and Sandu, K.
- Published
- 2020
- Full Text
- View/download PDF
3. Decoding supraglottic stenosis
- Author
-
Colliard, A., Ishii, A., De Sandre, Cecile, Gorostidi, F., and Sandu, K.
- Published
- 2020
- Full Text
- View/download PDF
4. Stenosi laringee dell’adulto
- Author
-
Lagier, A., Gorostidi, F., Demez, P., and Sandu, K.
- Published
- 2019
- Full Text
- View/download PDF
5. Carcinome anaplasique de la thyroïde : nouvelles approches thérapeutiques [Anaplastic thyroid carcinoma : new therapeutic approaches]
- Author
-
Stamatiou, A., Herrera-Gómez, R.G., Szturz, P., Bisig, B., Romano, E., Sykiotis, G., Gorostidi, F., La Rosa, S., Kopp, P., and Cristina, V.
- Subjects
Humans ,Mutation ,Proto-Oncogene Proteins B-raf/genetics ,Thyroid Carcinoma, Anaplastic/diagnosis ,Thyroid Carcinoma, Anaplastic/drug therapy ,Thyroid Carcinoma, Anaplastic/genetics ,Thyroid Neoplasms/diagnosis ,Thyroid Neoplasms/drug therapy ,Thyroid Neoplasms/genetics - Abstract
Anaplastic thyroid cancer (ATC) is among the most aggressive cancers with a median overall survival of 4 months and a disease-specific mortality of close to 100%. As soon as the diagnosis is suspected or established, urgent referral to an experienced multidisciplinary center is imperative. Chemotherapy has limited efficacy. Molecular analyses, together with the availability of novel targeted therapies and immunotherapies, now permit to improve outcomes. In particular, targeted therapy with dabrafenib and trametinib is indicated as first-line therapy for BRAF V600E-mutated ATC.
- Published
- 2021
6. Treatment outcomes in patients with laryngotracheal lesions and compromised airway during and prior to the coronovirus disease 2019 pandemic: a tertiary institution's experience
- Author
-
Gombert, E, primary, Ishii, A, additional, Guilcher, P, additional, Gorostidi, F, additional, Cantarella, G, additional, Pignataro, L, additional, and Sandu, K, additional
- Published
- 2021
- Full Text
- View/download PDF
7. Carcinome anaplasique de la thyroïde : nouvelles approches thérapeutiques [Anaplastic thyroid carcinoma : new therapeutic approaches]
- Author
-
Stamatiou, A, Herrera-Gómez, Rg, Szturz, P, Bisig, B, Romano, E, Sykiotis, G, Gorostidi, F, La Rosa, S, Kopp, P, and Cristina, V
- Published
- 2021
8. Réinnervations laryngées [Laryngeal reinnervation]
- Author
-
Salati, V., Beharry, A., Fries, S., Sandu, K., and Gorostidi, F.
- Abstract
The surgical management of unilateral and bilateral vocal cord paralysis depends on the severity of the condition, the potential for spontaneous recovery, the patient's age and vocal expectations. Standardized re-innervation surgeries, unilateral non-selective and bilateral selective, are viable alternatives to static procedures currently under evaluation in prospective studies. Neurorraphy of the ansa cervicalis loop to the recurrent laryngeal nerve allows lasting vocal recovery and potentially superior results to medialization and thyroplasty, by maintaining the visco-elastic properties of the vocal cord and preventing its atrophy. Selective bilateral reinnervation shows potential for recovery of inspiratory abduction with improved respiratory function without vocal deterioration.
- Published
- 2020
9. Anosmie et COVID-19 [Anosmia and COVID-19]
- Author
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Reinhard, A., Ikonomidis, C., Broome, M., and Gorostidi, F.
- Subjects
Betacoronavirus ,Coronavirus Infections/complications ,Coronavirus Infections/diagnosis ,Humans ,Olfaction Disorders/virology ,Pandemics ,Pneumonia, Viral/complications ,Pneumonia, Viral/diagnosis - Abstract
Anosmia associated or not with dysgeusia seems to be a frequent symptom in cases of infection with SARS-CoV-2 responsible for COVID-19. It can be the initial symptom of the disease or remain isolated in pauci-symptomatic patients. Waiting for scientific confirmation and in the context of the current pandemic, it seems essential to consider any patient with a new anosmia as being infected with SARS-CoV-2 until proven otherwise. These patients should therefore isolate themselves and remain alert to the occurrence of other symptoms suggestive of the infection and/or be tested. Topical and systemic corticosteroids and nose washes are contraindicated. The natural course of anosmia seems to be favorable in most cases.
- Published
- 2020
10. Decoding supraglottic stenosis
- Author
-
Colliard, A., primary, Ishii, A., additional, De Sandre, Cecile, additional, Gorostidi, F., additional, and Sandu, K., additional
- Published
- 2019
- Full Text
- View/download PDF
11. Endoscopic treatment of post-supraglottoplasty stenosis
- Author
-
Sandu, K., primary, Perez, M.H., additional, Longchamp, D., additional, Chollet, M., additional, and Gorostidi, F., additional
- Published
- 2018
- Full Text
- View/download PDF
12. Human and porcine urothelial stem cells
- Author
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Larsson, H. M., Gorostidi, F., Hubbell, J. A., Barrandon, Y., and Frey, P.
13. Single cell analysis of porcine and human urothelial cells
- Author
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Larsson, H. M., Gorostidi, F., Barrandon, Y., Hubbell, J. A., and Frey, P.
14. In vitro and in vivo operation of a wireless body sensor node
- Author
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Merli, F., Bolomey, L., Gorostidi, F., Barrandon, Y., Meurville, E., and Skrivervik, A. K.
15. Neonatal Linear Immunoglobulin A Bullous Dermatosis: A Critical Case Recovering after Prompt Recognition, Intensive Management, and Breastfeeding Interruption - A Case Report.
- Author
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Papasavva D, Dosso L, Morren MA, Fontao L, Bruschi L, Gorostidi F, Ferry T, Guenova E, Fischer Fumeaux CJ, and Joye S
- Abstract
Introduction: Neonatal linear immunoglobulin A (IgA) bullous dermatosis (NLABD) is a rare, life-threatening, mucocutaneous bullous disorder. The pathogenesis and optimal treatment remain poorly defined and raise critical clinical challenges., Case Presentation: We present a case of a full-term female infant with severe cutaneous and respiratory symptoms due to NLABD. Diagnosis was confirmed by immunofluorescence on the infant's skin biopsy, while IgAs directed against the basement membrane of the skin and mucosa were identified in the mother's milk. The infant fully recovered after nearly 8 weeks of intensive multidisciplinary care, including non-invasive ventilation, nutritional support, wound care, systemic corticoid treatment, and breastfeeding discontinuation., Conclusion: This case underscores the importance of timely adequate diagnosis and management of this rare and serious condition. Moreover, it adds novel evidence documenting the presence of pathogenic IgAs in breastmilk., (© 2024 The Author(s). Published by S. Karger AG, Basel.)
- Published
- 2024
- Full Text
- View/download PDF
16. Esophageal schwannoma mimicking non-functional parathyroid adenoma on 99m Tc-sestamibi imaging: a case report.
- Author
-
Fiore R, Gombert E, La Rosa S, Dunet V, Sykiotis GP, and Gorostidi F
- Subjects
- Humans, Female, Adult, Diagnosis, Differential, Esophageal Neoplasms diagnostic imaging, Esophageal Neoplasms diagnosis, Esophageal Neoplasms pathology, Esophageal Neoplasms surgery, Single Photon Emission Computed Tomography Computed Tomography, Radiopharmaceuticals, Technetium Tc 99m Sestamibi, Parathyroid Neoplasms diagnostic imaging, Parathyroid Neoplasms pathology, Parathyroid Neoplasms surgery, Parathyroid Neoplasms diagnosis, Neurilemmoma diagnostic imaging, Neurilemmoma pathology, Neurilemmoma diagnosis, Adenoma diagnostic imaging, Adenoma diagnosis, Adenoma pathology, Adenoma metabolism
- Abstract
Technetium-99m sestamibi single-photon emission computed tomography/computed tomography (
99m Tc-sestamibi SPECT/CT) is a mainstay of the pre-operative localization of parathyroid lesions. We report here the case of a 30 year-old woman with a fortuitously discovered 2 cm cervical mass for which a parathyroid origin was originally suspected due to its retro-thyroidal localization and a personal history of nephrolithiasis. Normal serum calcium and parathyroid hormone (PTH) levels excluded primary hyperparathyroidism, raising suspicion of a non-functional parathyroid adenoma, and SPECT/CT imaging showed that the mass was99m Tc-sestamibi-avid. Fine-needle aspiration (FNA) was performed; cytology was non-diagnostic but the needle washout was negative for thyroglobulin, calcitonin and PTH, arguing against a thyroidal or parathyroidal origin of the mass. Core needle biopsy revealed a schwannoma, ostensibly originating from the recurrent laryngeal nerve; upon surgical resection, it was finally found to arise from the esophageal submucosa. This case illustrates the fact that endocrinologists, radiologists, nuclear medicine, head and neck, and other specialists investigating patients with cervical masses should be aware that schwannomas need to be considered in the differential diagnosis of focal99m Tc-sestamibi uptake in the neck region., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Fiore, Gombert, La Rosa, Dunet, Sykiotis and Gorostidi.)- Published
- 2024
- Full Text
- View/download PDF
17. Oropharyngolaryngeal manifestations in severe toxic epidermal necrolysis: a single-center's retrospective case series.
- Author
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Glasson N, De Sandre C, Pantet O, Reinhard A, Lambercy K, Sandu K, and Gorostidi F
- Abstract
Background: Toxic epidermal necrolysis is a rare and life-threatening mucocutaneous disease. Although mucosal ear, nose, and throat (ENT) involvement is common, little is known about the characteristics, treatment modalities, and outcomes of these lesions. The aim of this study was to evaluate ENT mucosal lesions in severe toxic epidermal necrolysis patients and analyze their characteristics, treatment modalities, and outcomes, as well as proposing a management algorithm to prevent long-term debilitating sequalae of these lesions., Methods: This is a retrospective review of toxic epidermal necrolysis cases treated at the tertiary burns unit of the Lausanne University Hospital CHUV, Switzerland, between 2006 and 2019., Results: Out of 19 patients with severe toxic epidermal necrolysis, 17 (89%) underwent a complete ENT examination at admission and 14 (82%) had ENT mucosal involvement. Five (26.3%) patients died during the stay in the intensive care unit. Of the 16 patients who received maximal care, 13 (81%) required orotracheal intubation for a median time of 16 (IQR: 14) days. Out of the 14 patients who survived, four (29%) had long-term ENT complications consisting of synechiaes necessitating subsequent endoscopic procedures. Those four patients all required mechanical ventilation with an orotracheal tube and suffered from hypopharyngeal synechiaes as well as oral and endonasal synechiaes in individual cases., Conclusion: This study suggests a high prevalence of ENT synechiaes in patients with severe toxic epidermal necrolysis and requiring orotracheal intubation. Periodic ENT examination could prevent mature synechiae formation in these patients. We propose an algorithm to prevent long-term sequalae in ENT mucosal involvement., (© 2023 The Authors. International Journal of Dermatology published by Wiley Periodicals LLC on behalf of the International Society of Dermatology.)
- Published
- 2023
- Full Text
- View/download PDF
18. Congenital Malformations of the Cricoid Cartilage: Upper Airway Obstruction and Treatment Strategy.
- Author
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Gombert E, Gorostidi F, and Sandu K
- Subjects
- Child, Humans, Cricoid Cartilage surgery, Retrospective Studies, Treatment Outcome, Airway Obstruction etiology, Airway Obstruction surgery, Laryngostenosis etiology, Laryngostenosis surgery, Laryngostenosis diagnosis
- Abstract
Objectives: To review treatment and outcomes in patients with congenital cricoid cartilage malformation., Methods: Retrospective analysis of patients with diagnosis of congenital cricoid malformation (CCM) treated in a single tertiary pediatric referral center between 1985 and 2022. Patients were grouped according to the morphology of the cricoid cartilage that was diagnosed during endoscopy. We reviewed the treatment strategy(s), decannulation rate, complications, and functional outcomes., Results: Twenty-nine patients were grouped into four morphological subtypes of cricoid cartilage: 10 patients had a hypoplastic cricoid, eight had an elliptic shape, five had severe anterior thickening, and six an accentuated V-shape posterior cricoid plate. Twenty-four patients underwent surgery, and five were closely followed up without surgical treatment. Eight patients had a tracheostomy prior to surgery, and the majority had a hypoplastic cricoid. Most patients (20 out of 24) required additional procedures postoperatively to achieve an age-appropriate airway. Thirteen patients needed endoscopic dilatation(s) and granulation tissue removal; four needed more aggressive treatment, and three patients required revision open surgery. Decannulation was achieved after a median of 4.5 months in all previously tracheostomized patients. Endoscopy at the last follow-up showed an age-appropriate airway in 27 patients; 20 patients had normal oral feeding, and 11 patients had a normal voice., Conclusion: Endoscopy is important to diagnose CCM and most of the time patients would need only watchful waiting. In this report, surgery was required for patients who continued to remain symptomatic and had a compromised airway. The type of surgery depends on the type of cricoid malformation and the grade of stenosis., Level of Evidence: 4 Laryngoscope, 133:3185-3191, 2023., (© 2023 The Authors. The Laryngoscope published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc.)
- Published
- 2023
- Full Text
- View/download PDF
19. Enhancing Robustness of Adhesive Hydrogels through PEG-NHS Incorporation.
- Author
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Uslu E, Rana VK, Guo Y, Stampoultzis T, Gorostidi F, Sandu K, and Pioletti DP
- Subjects
- Adhesives, State Medicine, Biocompatible Materials, Acrylamides, Polyethylene Glycols pharmacology, Hydrogels pharmacology
- Abstract
Tissue wounds are a significant challenge for the healthcare system, affecting millions globally. Current methods like suturing and stapling have limitations as they inadequately cover the wound, fail to prevent fluid leakage, and increase the risk of infection. Effective solutions for diverse wound conditions are still lacking. Adhesive hydrogels, on the other hand, can be a potential alternative for wound care. They offer benefits such as firm sealing without leakage, easy and rapid application, and the provision of mechanical support and flexibility. However, the in vivo durability of hydrogels is often compromised by excessive swelling and unforeseen degradation, which limits their widespread use. In this study, we addressed the durability issues of the adhesive hydrogels by incorporating acrylamide polyethylene glycol N -hydroxysuccinimide (PEG-NHS) moieties (max. 2 wt %) into hydrogels based on hydroxy ethyl acrylamide (HEAam). The results showed that the addition of PEG-NHS significantly enhanced the adhesion performance, achieving up to 2-fold improvement on various soft tissues including skin, trachea, heart, lung, liver, and kidney. We further observed that the addition of PEG-NHS into the adhesive hydrogel network improved their intrinsic mechanical properties. The tensile modulus of these hydrogels increased up to 5-fold, while the swelling ratio decreased up to 2-fold in various media. These hydrogels also exhibited improved durability under the enzymatic and oxidative biodegradation induced conditions without causing any toxicity to the cells. To evaluate its potential for clinical applications, we used PEG-NHS based hydrogels to address tracheomalacia, a condition characterized by inadequate mechanical support of the airway due to weak/malacic cartilage rings. Ex vivo study confirmed that the addition of PEG-NHS to the hydrogel network prevented approximately 90% of airway collapse compared to the case without PEG-NHS. Overall, this study offers a promising approach to enhance the durability of adhesive hydrogels by the addition of PEG-NHS, thereby improving their overall performances for various biomedical applications.
- Published
- 2023
- Full Text
- View/download PDF
20. Preoperative CT-Based Skeletal Muscle Mass Depletion and Outcomes after Total Laryngectomy.
- Author
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Salati V, Mandralis K, Becce F, Koerfer J, Lambercy K, Simon C, and Gorostidi F
- Abstract
Purpose: To assess the role of preoperative CT-based skeletal muscle mass depletion on postoperative clinical outcomes and survival in patients who underwent total laryngectomy for cancer., Methods: Patients operated on between January 2011 and March 2020 were retrospectively included. Skeletal muscle area and intra- and inter-muscular fat accumulation were measured at the third lumbar vertebral level on preoperative CT scans. Skeletal muscle mass depletion was defined based on pre-established cut-off values. Their association with postoperative morbidity, length of stay (LOS), costs, and survival was assessed., Results: A total of 84 patients were included, of which 37 (44%) had preoperative skeletal muscle mass depletion. The rate of postoperative fistula (23% vs. 35%, p = 0.348), cutaneous cervical dehiscence (17% vs. 11%, p = 0.629), superficial incisional surgical site infections (SSI) (12% vs. 10%, p = 1.000), and unplanned reoperation (38% vs. 37%, p = 1.000) were comparable between the two patient groups. No difference in median LOS was observed (41 vs. 33 days, p = 0.295), nor in treatment costs (119,976 vs. 109,402 CHF, p = 0.585). The median overall survival was comparable between the two groups (3.43 vs. 4.95 years, p = 0.09)., Conclusions: Skeletal muscle mass depletion alone had no significant impact on postoperative clinical outcomes or survival.
- Published
- 2023
- Full Text
- View/download PDF
21. Wet adhesive hydrogels to correct malacic trachea (tracheomalacia) A proof of concept .
- Author
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Uslu E, Rana VK, Anagnostopoulos S, Karami P, Bergadano A, Courbon C, Gorostidi F, Sandu K, Stergiopulos N, and Pioletti DP
- Abstract
Tracheomalacia (TM) is a condition characterized by a weak tracheal cartilage and/or muscle, resulting in excessive collapse of the airway in the newborns. Current treatments including tracheal reconstruction, tracheoplasty, endo- and extra-luminal stents have limitations. To address these limitations, this work proposes a new strategy by wrapping an adhesive hydrogel patch around a malacic trachea. Through a numerical model, first it was demonstrated that a hydrogel patch with sufficient mechanical and adhesion strength can preserve the trachea's physiological shape. Accordingly, a new hydrogel providing robust adhesion on wet tracheal surfaces was synthesized employing the hydroxyethyl acrylamide (HEAam) and polyethylene glycol methacrylate (PEGDMA) as main polymer network and crosslinker, respectively. Ex vivo experiments revealed that the adhesive hydrogel patches can restrain the collapsing of malacic trachea under negative pressure. This study may open the possibility of using an adhesive hydrogel as a new approach in the difficult clinical situation of tracheomalacia., Competing Interests: The authors declare no competing interests., (© 2023 The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
22. Utility of flexible interventional endoscopy in endoscopic sinus surgery: a case series.
- Author
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Litzistorf Y, Gorostidi F, Lambercy K, and Reinhard A
- Subjects
- Humans, Endoscopy methods, Prospective Studies, Retrospective Studies, Frontal Sinus diagnostic imaging, Frontal Sinus surgery, Frontal Sinus pathology, Mucocele pathology, Mucocele surgery, Papilloma, Inverted diagnostic imaging, Papilloma, Inverted surgery, Papilloma, Inverted pathology
- Abstract
Purpose: During endoscopic sinus surgery (ESS), difficult-to-reach pathologies need an extended endoscopic approach or an external approach. We started to use a flexible interventional endoscope (FIE) to evaluate the necessity of those approaches. The study's objective is to describe our experience and define patients who could benefit from this technique., Methods: We reviewed every patient who benefited from FIE associated with ESS at our tertiary University Hospital between January 2021 and February 2022., Results: During this period, we did 107 ESS, and 14 patients benefited from the FIE, representing 13% of our ESS. The median duration of the flexible endoscopy time was 14 min (4-38 min). We identified three groups of patients who can benefit from the FIE. The first one is for patients with a fungal infection, to control and to clean lateral recesses in a noninvasive manner. The second one is for patients with a pathology of the lateral frontal sinus, to remove the frontoethmoidal cells or mucocele with the biopsy forceps through the working channel. The third group is for patients with inverted papillomas, to precisely identify the insertion and to decide on the most appropriate surgical approach., Conclusions: In selected cases, using flexible endoscopy during ESS helps decide the optimal surgical approach and sometimes treat the pathology through a limited approach. Prospective studies for each group of patients are needed to confirm the benefit of this new combined procedure., (© 2022. The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
23. Endoscopy-guided pharyngoesophageal stent fixation after total laryngectomy.
- Author
-
Salati V, Sandu K, and Gorostidi F
- Subjects
- Humans, Pharynx surgery, Endoscopy, Gastrointestinal, Laryngectomy, Laryngeal Neoplasms surgery
- Abstract
Competing Interests: The authors declare that they have no conflict of interest.
- Published
- 2022
- Full Text
- View/download PDF
24. Pediatric vascular anomalies with airway compromise.
- Author
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Gorostidi F, Glasson N, Salati V, and Sandu K
- Subjects
- Child, Female, Humans, Infant, Infant, Newborn, Pregnancy, Esthetics, Dental, Laryngostenosis, Prenatal Diagnosis adverse effects, Tracheotomy, Airway Obstruction etiology, Airway Obstruction surgery, Vascular Malformations
- Abstract
Vascular anomalies are rare lesions of diverse nature that may affect the head and neck region. Any mass in or around the upper airway has the potential to obstruct or compromise it. The absolute priority, before etiologic treatment, is the evaluation of the risk for the airway and its management. Prenatal diagnosis of an upper airway obstruction requires a planned delivery in a center having a specialized team experienced in managing a compromised feto-neonatal airway, and who could perform an ex-utero intrapartum treatment to secure the airway. Even after birth, the airway remains central in the patient's overall management. Signs and symptoms of airway compromise must be evaluated keeping in mind the specific requirements of infants and small children and being aware that rapid worsening may occur. The treatment is then tailored to the patient and his lesion with the goal of improving symptoms while avoiding treatment-related complications. Maintaining reasonable expectations by the patient and families are part of a successful management. Cure is achievable for small and localized lesions, but symptom relief and mitigation of functional, esthetic and psychological impairments is the goal for large and complex lesions. If a tracheotomy was required, decannulation is one of the primary management goals., (© 2022 The Authors. Journal of Oral Pathology & Medicine published by John Wiley & Sons Ltd.)
- Published
- 2022
- Full Text
- View/download PDF
25. Novel Technique for Fixing Tracheal Stents.
- Author
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Salati V, Lovis A, Gonzalez M, Sandu K, and Gorostidi F
- Subjects
- Bronchi, Humans, Stents, Trachea surgery, Airway Obstruction surgery, Tracheal Stenosis surgery
- Abstract
Endoscopic management of benign or malignant airway obstructions sometimes requires stenting after dilatation or debulking of the tumor. Straight stents are highly prone to migration in the trachea and the main bronchus, with potential catastrophic consequences. Multiple fixation strategies have been described to secure subglottic stents, each having certain limitations. This report describes a novel, "inside-to-outside" stent fixation in the upper airway using the Lichtenberger needle carrier in 2 consecutive patients., (Copyright © 2022 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
26. Minimally Invasive Endoscopic Sinus Surgery for Frontal Sinus Pathologies Using Interventional Flexible Bronchoscopy: Case Reports.
- Author
-
Litzistorf Y, Gorostidi F, and Reinhard A
- Abstract
Background : Lateral pathologies of the frontal sinus are difficult to visualize and treat with classical endoscopic sinus surgery (ESS) using rigid endoscopes and instruments. Hence, they often require extended endoscopic or external approaches. Methods and Results: We describe the advantages of using interventional flexible bronchoscopy in frontal ESS without extended approaches in 2 illustrated cases: (1) A fungus ball in the frontal sinus with a frontoethmoidal cell. The flexible bronchoscope allowed treatment of all recesses of the frontal sinuses and the opening of a frontoethmoidal cell through a Draf IIa. (2) A revision surgery with a frontoethmoidal cell obstructing drainage pathway was successfully treated with this same technique. Patients did not experience complications or recurrent symptomatology after, respectively, 4 and 15 months of follow-up. Conclusion: Flexible bronchoscopy allows a good visualization and treatment of lateral frontal sinus pathologies through limited endoscopic approaches. Through-the-scope instruments permit the resection of frontoethmoidal cells., Competing Interests: Declaration of Conflicting Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2021.)
- Published
- 2021
- Full Text
- View/download PDF
27. [Anaplastic thyroid carcinoma : new therapeutic approaches].
- Author
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Stamatiou A, Herrera-Gómez RG, Szturz P, Bisig B, Romano E, Sykiotis G, Gorostidi F, La Rosa S, Kopp P, and Cristina V
- Subjects
- Humans, Mutation, Proto-Oncogene Proteins B-raf genetics, Thyroid Carcinoma, Anaplastic diagnosis, Thyroid Carcinoma, Anaplastic drug therapy, Thyroid Carcinoma, Anaplastic genetics, Thyroid Neoplasms diagnosis, Thyroid Neoplasms drug therapy, Thyroid Neoplasms genetics
- Abstract
Anaplastic thyroid cancer (ATC) is among the most aggressive cancers with a median overall survival of 4 months and a disease-specific mortality of close to 100%. As soon as the diagnosis is suspected or established, urgent referral to an experienced multidisciplinary center is imperative. Chemotherapy has limited efficacy. Molecular analyses, together with the availability of novel targeted therapies and immunotherapies, now permit to improve outcomes. In particular, targeted therapy with dabrafenib and trametinib is indicated as first-line therapy for BRAF V600E-mutated ATC., Competing Interests: Le Pr Gerasimos Sykiotis a déclaré une activité de consultant auprès d’Eisai, Bayer et Eli Lilly. Le Dr Petr Szturz a déclaré une activité de consultant auprès de Merck-Serono, Servier et BMS. Les autres auteurs n’ont déclaré aucun conflit d’intérêts en relation avec cet article.
- Published
- 2021
28. [Laryngeal reinnervation].
- Author
-
Salati V, Beharry A, Fries S, Sandu K, and Gorostidi F
- Subjects
- Humans, Prospective Studies, Larynx surgery, Recurrent Laryngeal Nerve surgery, Vocal Cord Paralysis surgery, Vocal Cords surgery
- Abstract
The surgical management of unilateral and bilateral vocal cord paralysis depends on the severity of the condition, the potential for spontaneous recovery, the patient's age and vocal expectations. Standardized re-innervation surgeries, unilateral non-selective and bilateral selective, are viable alternatives to static procedures currently under evaluation in prospective studies. Neurorraphy of the ansa cervicalis loop to the recurrent laryngeal nerve allows lasting vocal recovery and potentially superior results to medialization and thyroplasty, by maintaining the visco-elastic properties of the vocal cord and preventing its atrophy. Selective bilateral reinnervation shows potential for recovery of inspiratory abduction with improved respiratory function without vocal deterioration., Competing Interests: Les auteurs n’ont déclaré aucun conflit d’intérêts en relation avec cet article.
- Published
- 2020
29. Head and neck tumors angiogenesis imaging with 68 Ga-NODAGA-RGD in comparison to 18 F-FDG PET/CT: a pilot study.
- Author
-
Durante S, Dunet V, Gorostidi F, Mitsakis P, Schaefer N, Delage J, and Prior JO
- Abstract
Background: Angiogenesis plays an important role in head and neck squamous cell carcinoma (HNSCC) progression. This pilot study was designed to compare the distribution of
68 Ga-NODAGA-RGD PET/CT for imaging αv β3 integrins involved in tumor angiogenesis to18 F-FDG PET/CT in patients with HNSCC., Material and Methods: Ten patients (aged 58.4 ± 8.3 years [range, 44-73 years], 6 males, 4 females) with a total of 11 HNSCC were prospectively enrolled. Activity mapping and standard uptake values (SUV) from both68 Ga-NODAGA-RGD and18 F-FDG PET/CT scans were recorded for primary tumor and compared with the Wilcoxon signed-rank test. The relation between the SUV of both tracers was assessed using the Spearman correlation., Results: All HNSCC tumors were visible with both tracers. Quantitative analysis showed higher18 F-FDG SUVmax in comparison to68 Ga-NODAGA-RGD (14.0 ± 6.1 versus 3.9 ± 1.1 g/mL, p = 0.0017) and SUVmean (8.2 ± 3.1 versus 2.0 ± 0.8 g/mL, p = 0.0017). Both18 F-FDG and68 Ga-NODAGA-RGD uptakes were neither correlated with grade, HPV status nor p16 protein expression (p ≥ 0.17)., Conclusion: All HNSCC tumors were detected with both tracers with higher uptake with18 F-FDG, however.68 Ga-NODAGA-RGD has a different spatial distribution than18 F-FDG bringing different tumor information., Trial Registration: NCT, NCT02666547. Registered 12.8.2012.- Published
- 2020
- Full Text
- View/download PDF
30. [Anosmia and COVID-19].
- Author
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Reinhard A, Ikonomidis C, Broome M, and Gorostidi F
- Subjects
- COVID-19, Coronavirus Infections diagnosis, Humans, Pandemics, Pneumonia, Viral diagnosis, SARS-CoV-2, Betacoronavirus, Coronavirus Infections complications, Olfaction Disorders virology, Pneumonia, Viral complications
- Abstract
Anosmia associated or not with dysgeusia seems to be a frequent symptom in cases of infection with SARS-CoV-2 responsible for COVID-19. It can be the initial symptom of the disease or remain isolated in pauci-symptomatic patients. Waiting for scientific confirmation and in the context of the current pandemic, it seems essential to consider any patient with a new anosmia as being infected with SARS-CoV-2 until proven otherwise. These patients should therefore isolate themselves and remain alert to the occurrence of other symptoms suggestive of the infection and/or be tested. Topical and systemic corticosteroids and nose washes are contraindicated. The natural course of anosmia seems to be favorable in most cases., Competing Interests: Les auteurs n’ont déclaré aucun conflit d’intérêts en relation avec cet article.
- Published
- 2020
31. [Thyroid nodules and thyroid differentiated cancers: an update on diagnosis and surgical management.]
- Author
-
De Sandre-Mouly C, Sykiotis GP, Simon C, and Gorostidi F
- Subjects
- Humans, Thyroidectomy, Ultrasonography, Thyroid Neoplasms diagnosis, Thyroid Neoplasms surgery, Thyroid Nodule diagnosis, Thyroid Nodule surgery
- Abstract
The incidence of differentiated thyroid cancers has increased in the past 30 years, mainly due to overdiagnosis. It is therefore crucial to adapt diagnostic and therapeutic approaches to avoid overtreatment that exposes patients to unnecessary risks. Accordingly, international guidelines on the subject are regularly updated. Ultrasound and cytology guide the management for thyroid nodules. Some microcarcinomas can now be actively followed without immediate surgery, and some low-risk cancers can be adequately treated with lobo-isthmectomy. The indications for central neck dissection remain controversial. Technological advances allow minimizing specific complications of thyroid surgery and facilitate scarless surgery., Competing Interests: Les auteurs n’ont déclaré aucun conflit d’intérêts en relation avec cet article.
- Published
- 2019
32. Lamb larynx model for training in endoscopic and CO 2 laser-assisted surgeries for benign laryngotracheal obstructions.
- Author
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Gorostidi F, Vinckenbosch P, Lambercy K, and Sandu K
- Subjects
- Animals, Disease Models, Animal, Endoscopy methods, Sheep, Surgical Equipment, Treatment Outcome, Endoscopy education, Laryngostenosis surgery, Larynx surgery, Laser Therapy methods, Lasers, Gas therapeutic use, Otolaryngology education, Tracheal Stenosis surgery
- Abstract
Purpose: With adequate indication and meticulous execution, endoscopic procedures can efficiently treat a subset of adult and pediatric benign laryngotracheal stenosis and obstructions, but these procedures are precise and very demanding. The difference between a successful and a failed surgery, with potentially debilitating side effects, resides in small details. The learning curve is long and very few centers worldwide have a sufficient case load making adequate training difficult. While indications and concepts of endoscopic procedures can be learned in books and by observing trained colleagues, the dexterity and the precise realization need to be practiced, ideally not initially on patients., Methods: We describe here the lamb model system for the initial training in such procedures. We provide a step-by-step guide for endoscopic approaches intended to treat pathologies such as laryngomalacia, bilateral vocal fold paralysis, posterior glottic stenosis, and laryngotracheal clefts., Conclusions: The lamb model system does not pose ethical issues, and it is easy to obtain and to handle. It was used during an international training course for laryngotracheal stenosis by novice and advanced airway surgeons. It was unanimously judged as relevant and useful by the participants.
- Published
- 2018
- Full Text
- View/download PDF
33. Graves Disease Causing Pancytopenia: Case Report and Literature Review.
- Author
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Pincet L and Gorostidi F
- Abstract
Background: Graves disease or other causes of thyrotoxicosis are frequently associated with cytopenia. Although anemia is the most common, other cell lineage can be affected. Pancytopenia is a rare complication of thyrotoxicosis., Case Presentation: We report a case of a 33-year-old Chinese man who presented a nonsevere pancytopenia in the context of a newly diagnosed Graves disease. Restauration of euthyroid state led to progressive correction of pancytopenia., Conclusions: Literature review shows other rare cases of pancytopenia. It is usually nonsevere with just extremely rare cases of transfusion reported. Evolution was always favorable after achievement of euthyroid state. Its mechanism remains poorly understood, especially because those patients have no vitamin or iron deficiency. The exact physiopathological process remains unclear but 2 causes seem to overlap: reduced production of hematopoietic cells from the bone marrow and increased destruction or sequestration of mature hematopoietic cells. Despite unclear mechanism, the presence of hematologic abnormalities including pancytopenia must not be considered as a contraindication to antithyroid drug therapy., Competing Interests: Declaration of conflicting interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2018
- Full Text
- View/download PDF
34. Extraluminal biodegradable splint to treat upper airway anterior malacia: A preclinical proof of principle.
- Author
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Gorostidi F, Courbon C, Burki M, Reinhard A, and Sandu K
- Subjects
- Animals, Disease Models, Animal, Endoscopy methods, Female, Prospective Studies, Rabbits, Survival Rate, Trachea surgery, Absorbable Implants adverse effects, Splints adverse effects, Tracheomalacia surgery
- Abstract
Objective: Upper airway malacia highly complicates the treatment of benign laryngotracheal stenosis, and no ideal option is available to date. We here explore the use of extraluminal biodegradable splints in an animal model of long-segment anterior tracheomalacia (TM). We show the efficacy, as well as the tissue tolerance, of a custom-made biodegradable extraluminal device surgically inserted around the trachea., Study Design: Preclinical animal study., Methods: Anterior TM was induced in rabbits through an anterior neck approach by removing eight consecutive anterior tracheal rings without damaging the underlying mucosa. Malacia was corrected during the same surgery by pexy sutures, suspending the tracheal mucosa to an experimental biodegradable device. Symptoms, survival, and tissue reaction were compared to healthy and sham surgery controls., Results: The model induced death by respiratory failure within minutes. Ten animals received the experimental treatment, and those who survived the perioperative period remained asymptomatic with a maximum follow-up of 221 days. Histological studies at programmed euthanasia showed complete degradation of the prosthesis, with significant remnant fibrosis around the trachea. However, the tracheal stiffness of test segments was comparatively less than that of control segments., Conclusion: Extraluminal biodegradable splints rescued animals with a condition otherwise incompatible with life. It was well tolerated, leaving peritracheal fibrosis that was not as stiff as normal trachea. The external tracheal stiffening was sufficient for the test animals to live through the phase of severe acute hypercollapsibility. This represents a valid option to help pediatric patients with laryngotracheal stenosis and associated cartilaginous airway malacia., Level of Evidence: NA. Laryngoscope, 128:E53-E58, 2018., (© 2017 The American Laryngological, Rhinological and Otological Society, Inc.)
- Published
- 2018
- Full Text
- View/download PDF
35. Temporary tracheal stenting using endovascular prosthesis in the management of severe refractory stenosis following slide tracheoplasty.
- Author
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Sandu K, Reinhard A, Lambercy K, Pretre R, and Gorostidi F
- Subjects
- Child, Preschool, Female, Humans, Male, Severity of Illness Index, Trachea surgery, Tracheal Stenosis congenital, Endoscopy, Stents, Tracheal Stenosis surgery
- Abstract
Objectives: To evaluate the role of endovascular stents in temporary tracheal stenting and endoscopic treatment strategy for patients with severe refractory tracheal stenosis following slide tracheoplasty., Methods: Two patients had severe tracheal stenosis after slide tracheoplasty for long segment congenital tracheal stenosis. Both these patients were managed endoscopically and an endovascular prosthesis was used to temporarily stent the trachea. Short and long term results were evaluated clinically and with repeated endoscopies., Results: The 2 patients had an excellent recovery immediately after the stent placement and continue to have an optimal, age-appropriate stable tracheal diameter after stent removal., Conclusion: Endovascular stents can be temporarily used to stent the trachea in the endoscopic treatment strategy to correct refractory severe tracheal stenosis following slide tracheoplasty.
- Published
- 2018
- Full Text
- View/download PDF
36. L-Shaped Septal Extension Spreader Graft for Improvement of Tip Symmetry in Unilateral Cleft Lip Nose Deformities.
- Author
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Sertel S, Venara-Vulpe II, Gorostidi F, de Buys Roessingh A, and Pasche P
- Subjects
- Adolescent, Adult, Cleft Lip diagnosis, Cohort Studies, Esthetics, Female, Humans, Male, Nasal Cartilages surgery, Nose abnormalities, Retrospective Studies, Risk Assessment, Tissue Transplantation methods, Wound Healing physiology, Young Adult, Cleft Lip surgery, Nasal Septum surgery, Nose surgery, Rhinoplasty methods, Tissue Expansion methods
- Abstract
Introduction: The unilateral cleft lip nose is characterized by numerous complex and interdependent deformities. Secondary rhinoplasty techniques aim to correct cleft lip nose deformities by using multiple maneuvers combining septum and nasal spine medialization and alar cartilage, as well as soft tissue mobilization and repositioning. Moreover, cartilage grafting is frequently used to restore adequate tip projection and nasal symmetry. We present a technique of cartilage grafting commonly used in noncleft rhinoplasties that we modified for cases of moderate cleft lip nose deformities., Patients and Methods: We present a retrospective case study of 21 patients with moderate unilateral cleft lip nose deformities who underwent secondary septorhinoplasty with an L-shaped septal extension spreader graft combined with alar rim, alar batten graft, and soft tissue repositioning. Exclusion criteria were severe or complex septal deviation avoiding a stable fixation of the graft. Mean follow-up time was 28 months. Surgical outcomes were analyzed by anthropometric measurements of standardized preoperative and postoperative photographs., Results: All parameters improved except for the nostril height. The height between the alar base and the dome defining dome symmetry, as well as the angles between the lower lateral cartilage and the alar base (α) defining the orientation of the alar rim, improved significantly. The mean ratios of cleft/noncleft side of the height between the alar base and the dome and α showed statistically significant improvements from 0.833 (preoperative) to 0.994 (postoperative) (P < 0.0001) and from 0.883 to 1.02 (P = 0.0038), respectively., Conclusions: The L-shaped septal extension spreader graft combined with alar batten graft and soft tissue repositioning is an option for secondary rhinoplasties in unilateral cleft lip nose deformities minimizing tip rigidity with significant improvement of the dome's height and its symmetry, as well as the alar side angle.
- Published
- 2017
- Full Text
- View/download PDF
37. Laser supraglottoplasty for laryngomalacia; a 14 year experience of a tertiary referral center.
- Author
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Reinhard A, Gorostidi F, Leishman C, Monnier P, and Sandu K
- Subjects
- Child, Child, Preschool, Comorbidity, Female, Humans, Infant, Infant, Newborn, Infant, Premature, Laryngomalacia complications, Laryngomalacia pathology, Male, Retrospective Studies, Tertiary Care Centers, Treatment Outcome, Laryngomalacia surgery, Laser Therapy
- Abstract
To review the outcomes of laser supraglottoplasty performed in children with symptomatic laryngomalacia and determine the factors influencing them. We retrospectively reviewed the medical records of patients who underwent laser supraglottoplasty for symptomatic laryngomalacia at the Lausanne University Hospital from November 2001 to November 2014. We examined the patient's demography, symptoms, comorbidities, type of laryngomalacia, synchronous airway lesions, and final outcomes. Seventy-nine patients were included in this study; median age at the time of surgery was 12.7 months. 55.7 % of the cases had comorbidities, 22.8 % of the patients were premature and synchronous airway lesions were present in 32.9 % of the cases. The different morphological types of laryngomalacia (I-III) were seen in 26.6, 62 and 11.4 % of the patients, respectively. Overall, operation specific success rate of laser supraglottoplasty was 86.1 %. Failures in 11 (13.9 %) of the 79 cases required 15 revision procedures. Success rates for patients with associated comorbidities, synchronous airway lesions, neurological disorders and prematurity were 81.8, 76.9, 69.2 and 66.7 %, respectively. Patients with type III laryngomalacia had a limited success rate (66.7 %) as compared to patients with morphological types I and II (90.5 and 87.8 %, respectively). Laser supraglottoplasty is an effective and safe treatment for symptomatic laryngomalacia. Patients with prematurity, type III LM, synchronous airway lesions and associated comorbidities are predisposed to surgical failure.
- Published
- 2017
- Full Text
- View/download PDF
38. External bioresorbable airway rigidification to treat refractory localized tracheomalacia.
- Author
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Gorostidi F, Reinhard A, Monnier P, and Sandu K
- Subjects
- Adult, Airway Obstruction etiology, Airway Obstruction surgery, Child, Child, Preschool, Device Removal, Female, Follow-Up Studies, Humans, Infant, Male, Recurrence, Retrospective Studies, Trachea surgery, Tracheal Stenosis complications, Tracheomalacia complications, Treatment Outcome, Absorbable Implants, Bronchoscopy methods, Laryngoscopy methods, Tracheal Stenosis surgery, Tracheomalacia surgery
- Abstract
Objectives/hypothesis: Our study evaluates the efficacy of extraluminal bioresorbable plates to treat refractory localized airway malacia in patients undergoing corrective surgery for complex multilevel laryngotracheal stenosis., Study Design: Retrospective case series., Methods: Secondary malacic airway segments were characterized (severity, site, type) by a dynamic transnasal flexible laryngotracheobronchoscopy before surgery. Extraluminal bioresorbable plates were used to stabilize the malacic segment through a transcervical approach under intraoperative flexible endoscopic guidance. Results were evaluated subjectively and by a postoperative dynamic endoscopy. We report our experience in seven patients (6 children, 1 adult)., Results: External tracheal stiffening allowed complete or partial resolution of refractory proximal airway malacia in six of seven complex cases described (result in one case is awaited). It allowed quick decannulation in four of seven patients who experienced multiple previous failures. Decannulation failures were due to recurrence of stenosis. With up to 2 years of follow-up, we report no direct complications related to the presence of extraluminal bioresorbable plates around the airway., Conclusion: Extraluminal biodegradable tracheal stiffening represents a valid therapeutic option in select cases of upper airway malacia. It can be highly useful in cases of complex multilevel airway obstructions. External stiffening needs to be planned on a case-to-case basis according to the type of malacia and must be performed under endoscopic guidance., Level of Evidence: 4. Laryngoscope, 126:2605-2610, 2016., (© 2016 The American Laryngological, Rhinological and Otological Society, Inc.)
- Published
- 2016
- Full Text
- View/download PDF
39. Congenital lobar emphysema presenting as an airway foreign body.
- Author
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Gorostidi F, de Buys Roessingh A, Gonzalez M, Simon C, and Monnier Y
- Subjects
- Bronchoscopy, Diagnosis, Differential, Female, Foreign Bodies diagnostic imaging, Humans, Infant, Pulmonary Emphysema diagnosis, Pulmonary Emphysema diagnostic imaging, Radiography, Respiratory Aspiration diagnostic imaging, Foreign Bodies diagnosis, Pulmonary Emphysema congenital, Respiratory Aspiration diagnosis
- Abstract
We report here the case of a 15 months old girl presenting with clinical signs and radiological exams highly suggestive of a foreign body (FB) aspiration. Diagnostic endoscopy revealed an overlooked bronchial malformation responsible for a congenital lobar emphysema (CLE). CLE presenting after one year of age is rare and can easily be misdiagnosed. Therefore, the possibility of an overlooked CLE needs to be known and evoked as an alternative diagnosis when dealing with children presenting with suspected FB aspirations. We report on this unexpected, yet misleading presentation of CLE and review the available literature on the subject., (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
40. Endoscopic epiglottopexy using Lichtenberger's needle carrier to avoid breakdown of repair.
- Author
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Sandu K, Monnier P, Reinhard A, and Gorostidi F
- Subjects
- Child, Child, Preschool, Female, Humans, Infant, Laryngomalacia surgery, Male, Sutures, Epiglottis surgery, Laryngoscopy, Suture Techniques instrumentation
- Abstract
Severe type III laryngomalacia LM is represented by a retroflexed epiglottis that touches the posterior pharyngeal wall and obstructs the laryngeal inlet. Endoscopic epiglottopexy is advised in such cases wherein pexy sutures are passed between the epiglottis and base of tongue. Using conventional needle carriers, it is difficult to pass such sutures that go deep enough into the tongue base. Such a pexy is prone to a break down. We describe a novel technique of placing these glossoepiglottic sutures using the Lichtenberger's needle carrier. We used this technique in three patients with excellent results and report no complications. We propose to use this technique in cases of epiglottic prolapse seen in severe LM and certain hypotonic conditions.
- Published
- 2015
- Full Text
- View/download PDF
41. Clonal, self-renewing and differentiating human and porcine urothelial cells, a novel stem cell population.
- Author
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Larsson HM, Gorostidi F, Hubbell JA, Barrandon Y, and Frey P
- Subjects
- Animals, Cell Culture Techniques, Cell Separation, Clone Cells cytology, Humans, Mice, Swine, Ureter cytology, Cell Differentiation, Stem Cells cytology, Urothelium cytology
- Abstract
Although urothelial progenitor-like cells have been described in the human urinary tract, the existence of stem cells remains to be proven. Using a culture system that favors clonogenic epithelial cell growth, we evaluated and characterized clonal human urothelial cells. We isolated human urothelial cells that were clonogenic, capable of self-renewal and could develop into fully differentiated urothelium once re-implanted into the subcapsular space of nude mice. In addition to final urothelial cell differentiation, spontaneous formation of bladder-like microstructures was observed. By examining an epithelial stem cell signature marker, we found p63 to correlate with the self-renewal capacity of the isolated human urothelial clonal populations. Since a clinically relevant, long-term model for functional reconstitution of human cells does not exist, we sought to establish a culture method for porcine urothelial cells in a clinically relevant porcine model. We isolated cells from porcine ureter, urethra and bladder that were clonogenic and capable of self-renewal and differentiation into fully mature urothelium. In conclusion, we could isolate human and porcine cell populations, behaving as urothelial stem cells and showing clonogenicity, self-renewal and, once re-implanted, morphological differentiation.
- Published
- 2014
- Full Text
- View/download PDF
42. Capturing epidermal stemness for regenerative medicine.
- Author
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Barrandon Y, Grasset N, Zaffalon A, Gorostidi F, Claudinot S, Droz-Georget SL, Nanba D, and Rochat A
- Subjects
- Animals, Cell- and Tissue-Based Therapy, Humans, Regenerative Medicine, Skin Diseases therapy, Epidermal Cells, Epithelial-Mesenchymal Transition, Stem Cells cytology
- Abstract
The skin is privileged because several skin-derived stem cells (epithelial stem cells from epidermis and its appendages, mesenchymal stem cells from dermis and subcutis, melanocyte stem cells) can be efficiently captured for therapeutic use. Main indications remain the permanent coverage of extensive third degree burns and healing of chronic cutaneous wounds, but recent advances in gene therapy technology open the door to the treatment of disabling inherited skin diseases with genetically corrected keratinocyte stem cells. Therapeutic skin stem cells that were initially cultured in research or hospital laboratories must be produced according strict regulatory guidelines, which ensure patients and medical teams that the medicinal cell products are safe, of constant quality and manufactured according to state-of-the art technology. Nonetheless, it does not warrant clinical efficacy and permanent engraftment of autologous stem cells remains variable. There are many challenges ahead to improve efficacy among which to keep telomere-dependent senescence and telomere-independent senescence (clonal conversion) to a minimum in cell culture and to understand the cellular and molecular mechanisms implicated in engraftment. Finally, medicinal stem cells are expansive to produce and reimbursement of costs by health insurances is a major concern in many countries., (© 2012 Elsevier Ltd. All rights reserved.)
- Published
- 2012
- Full Text
- View/download PDF
43. [Review of recent trends in ophthalmology].
- Author
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BESSIERE E, MIRANDE B, and GOROSTIDI F
- Subjects
- Humans, Ophthalmology
- Published
- 1958
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