Search

Your search keyword '"Gornitzky, Alex L."' showing total 33 results
Start Over Author "Gornitzky, Alex L."
33 results on '"Gornitzky, Alex L."'

2. Effect of non-steroidal anti-inflammatory drugs on fracture healing in children: A systematic review

Author

Stroud, Sarah, Katyal, Toshali, Gornitzky, Alex L, and Swarup, Ishaan

Subjects
Physical Injury - Accidents and Adverse Effects, Clinical Research, Patient Safety, Pediatric, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Injuries and accidents, Musculoskeletal, Non-steroidal anti-inflammatory drug, Nonunion, Complication, Pediatric fractures, Pain management, Bone healing
Abstract

BackgroundNon-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed medications in the United States. Although they are safe and effective means of analgesia for children with broken bones, there is considerable variation in their clinical use due to persistent concerns about their potentially adverse effect on fracture healing.AimTo assess whether NSAID exposure is a risk factor for fracture nonunion in children.MethodsWe systematically reviewed the literature reporting the effect of NSAIDs on bone healing. We included all clinical studies that reported on adverse bone healing complications in children with respect to NSAID exposure. The outcomes of interest were delayed union or nonunion. Study quality was assessed using the Newcastle-Ottawa scale for non-randomized studies. A final table was constructed summarizing the available evidence.ResultsA total of 120 articles were identified and screened, of which 6 articles were included for final review. Nonunion in children is extremely rare; among the studies included, there were 2011 nonunions among 238822 fractures (0.84%). None of the included studies documented an increased risk of nonunion or delayed bone healing in those children who are treated with NSAIDs in the immediate post-injury or peri-operative time period. Additionally, children are likely to take these medications for only a few days after injury or surgery, further decreasing their risk of adverse side-effects.ConclusionThis systematic review suggests that NSAIDS can be safely prescribed to pediatric orthopaedic patients absent other contraindications without concern for increased risk of fracture non-union or delayed bone healing. Additional prospective studies are needed focusing on higher risk fractures and elective orthopaedic procedures such as osteotomies and spinal fusion.

Published
2022

10. List of Contributors

Author

Ahmad, Sufian S., primary, Akita, Keiichi, additional, Alvarez, Pedro, additional, Amis, Andrew A., additional, Andrews, James R., additional, Anz, Adam W., additional, Ares, Oscar, additional, Argentieri, Erin C., additional, Avbelj, Viktor, additional, Balazs, George C., additional, Barber, F. Alan, additional, Barber-Westin, Sue D., additional, Bareka, Metaxia, additional, Barnthouse, Cris D., additional, Barrett, Austin M., additional, Barrett, Gene R., additional, Basdekis, George, additional, Beck, Charles L., additional, Bedi, Asheesh, additional, Benner, Rodney W., additional, Bernard, Manfred, additional, Bernholt, David L., additional, Beynnon, Bruce D., additional, Bisson, Leslie J., additional, Björnsson, Haukur, additional, Blagojevic´, Zoran, additional, Bogunovic, Ljiljana, additional, Briggs, Karen, additional, Brophy, Robert, additional, Brotherton, Scott L., additional, Brown, Charles H., additional, Brown, Taylor D., additional, Browne, Jon E., additional, Chahla, Jorge, additional, Chau, Jackie Yee-Man, additional, Chan, William Wai-Lam, additional, Chisholm, Mary F., additional, Cole, Brian J., additional, Collins, Amber T., additional, Collins, Malcolm, additional, Crossley, Kay M., additional, Cugat, Ramón, additional, Cuscó, Xavier, additional, DeBerardino, Thomas M., additional, Denaro, Vincenzo, additional, Dreese, James C., additional, Dukas, Alex G., additional, Duthon, Victoria B., additional, Ejerhed, Lars, additional, Ernest, Christian, additional, Evangelopoulos, Dimitrios S., additional, Everhart, Joshua S., additional, Fabricant, Peter D., additional, Feller, Julian A., additional, Fideler, Kathryn, additional, Filbay, Stephanie R., additional, Finkle, Susan M., additional, Flanigan, David C., additional, Francisco, Ramces, additional, Frank, Rachel M., additional, Fromm, Stuart E., additional, Fu, Freddie H., additional, Fulkerson, John P., additional, Ganapathy, Pramodh K., additional, Ganley, Theodore J., additional, Garrett, William E., additional, Georgoulis, Anastasios, additional, Gill, Thomas J., additional, Gornitzky, Alex L., additional, Goyeneche, Nicholas P., additional, Gray, Tinker, additional, Griffin, Letha Y., additional, Griffith, Chad J., additional, Gobbi, Alberto, additional, Guenther, Daniel, additional, Hackel, Joshua G., additional, Hadjicostas, Panayiotis T., additional, Han, Yung, additional, Hantes, Michael E., additional, Harlem, Thomas, additional, Harris, Joshua D., additional, Hecker, Aaron, additional, Ho, Sherwin S.W., additional, Howell, Stephen M., additional, Hutchinson, Mark R., additional, Imbert, Pierre, additional, Indelicato, Peter A., additional, Inderhaug, Eivind, additional, Irarrázaval, Sebastián, additional, Janssen, Daan Martijn, additional, Janssen, Rob P.A., additional, Järvelä, Timo, additional, Javernick, Matt, additional, Jiang, Jie, additional, Johnson, Darren L., additional, Johnson, Don, additional, Joyce, Brian T., additional, Jung, Min, additional, Kaeding, Christopher C., additional, Kalawadia, Jay V., additional, Kamath, Ganesh, additional, Karistinos, Anastassios, additional, Karlsson, Jón, additional, Karnatzikos, Georgios, additional, Kartus, Jüri, additional, Keating, John, additional, Kennedy, Nicholas I., additional, Kercher, James, additional, Khan, Umar, additional, Kim, Walter, additional, Kluczynski, Melissa A., additional, Koh, Jason L., additional, Kohl, Sandro, additional, Kousa, Petteri, additional, LaPrade, Christopher M., additional, LaPrade, Robert F., additional, Laupattarakasem, Pat, additional, Laupattarakasem, Wiroon, additional, Lawhorn, Keith W., additional, Leong, Natalie L., additional, Loveland, Dustin M., additional, Lynch, T. Sean, additional, Mackay, Gordon, additional, Maffuli, Nicola, additional, Magnussen, Robert A., additional, Maloney, Mike, additional, Mandelbaum, Bert R., additional, Mardam-Bey, Sami W., additional, Marx, Robert G., additional, McAllister, David R., additional, McCarty, Eric, additional, McCullough, Kirk A., additional, Menon, Sanjay, additional, Meuffels, Duncan E., additional, Metzler, Adam V., additional, Michaelson, Jefferey, additional, Mijic, Dragomir, additional, Milano, Giuseppe, additional, Milisavljevic´, Milan, additional, Mithoefer, Kai, additional, Mlynarek, Ryan A., additional, Mochizuki, Tomoyuki, additional, Mohankumar, Rakesh, additional, Moraiti, Constantina, additional, Moran, Ray, additional, Moulton, Samuel G., additional, Mudhigere, Abhishek, additional, Muneta, Takeshi, additional, Murphy, Brian J., additional, Nakamura, Norimasa, additional, Naraghi, Ali M., additional, Nicandri, Gregg, additional, Nikolic´, Valentina, additional, Noyes, Frank R., additional, Nurmi, Janne T., additional, O’Byrne, John, additional, Ochi, Mitsuo, additional, Paessler, Hans Heinrich, additional, Pandit, Hemant, additional, Papalia, Rocco, additional, Pappas, Evangelos, additional, Paschos, Nikolaos K., additional, Patzakis, Michael J., additional, Paulos, Lonnie E., additional, Peterson, Lars, additional, Philippon, Marc J., additional, Poage, Chad H., additional, Posthumus, Michael, additional, Prodromos, Chadwick C., additional, Rashkovska, Aleksandra, additional, Reijman, Max, additional, Rennicke, Jordan C., additional, Ristanis, Stavros, additional, Rius, Marta, additional, Rogowski, Julie, additional, Rossi, Nicholas, additional, Rue, John-Paul, additional, Saccomanno, Maristella F., additional, Sallent, Andrea, additional, Sasaki, Norihiro, additional, Sayde, William M., additional, Scheffler, Sven, additional, Schlatterer, Bernard, additional, Schmitt, Laura C., additional, Schoenfeldt, Ted, additional, Seijas, Roberto, additional, September, Alison V., additional, Shaarani, Shahril R., additional, Shaikh, Humza S., additional, Shaw, Christopher M., additional, Shelbourne, K. Donald, additional, Shelton, Walter, additional, Shin, Jason J., additional, Shino, Konsei, additional, Silvers, Holly J., additional, Simeoforidou, Marina, additional, Sims, Laura A., additional, Sklar, Joseph H., additional, Smith, Angela H., additional, Smyth, Mark P., additional, Sommerfeldt, Mark F., additional, Spindler, Kurt P., additional, Steiner, Mark E., additional, Stergiou, Nicholas, additional, Stevanovic´, Vladan, additional, Tecame, Andrea, additional, Tejwani, Samir G., additional, Terzidis, Ioannis, additional, Thoma, Louise, additional, Tilton, Annemarie K., additional, Timmerman, Laura A., additional, Tohyama, Harukazu, additional, Tsarouhas, Alexander, additional, Tsepis, Elias, additional, Trobec, Roman, additional, Lee Turnbull, Travis, additional, Uribe, John W., additional, van Meer, Belle L., additional, van Mourik, Jan B.A., additional, Van Thiel, Geoffrey, additional, Varkey, Dax, additional, Vasta, Sebastiano, additional, Veselko, Matjaž, additional, Wade, Sean M., additional, Wall, Andrew, additional, Ware, James Kristopher, additional, Waterman, Brian R., additional, Webster, Kate E., additional, Westermann, Robert W., additional, Wolf, Brian R., additional, Wright, Rick W., additional, Xergia, Sofia A., additional, Xerogeanes, John William, additional, Yanke, Adam, additional, Yasuda, Kazunori, additional, Yi, Seung Jin, additional, Zalavras, Charalampos G., additional, Zampeli, Franceska, additional, Zarins, Bertram, additional, and Zhao, Jinzhong, additional

Published
2018
Full Text
View/download PDF

19. Effect of non-steroidal anti-inflammatory drugs on fracture healing in children: A systematic review

Author

Stroud, Sarah, Katyal, Toshali, Gornitzky, Alex L, and Swarup, Ishaan

Subjects
Bone healing, Pediatric, Physical Injury - Accidents and Adverse Effects, Pediatric fractures, Evaluation of treatments and therapeutic interventions, Injuries and accidents, Pain management, Nonunion, Clinical Research, 6.1 Pharmaceuticals, Musculoskeletal, Orthopedics and Sports Medicine, Patient Safety, Non-steroidal anti-inflammatory drug, Complication
Abstract

BackgroundNon-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed medications in the United States. Although they are safe and effective means of analgesia for children with broken bones, there is considerable variation in their clinical use due to persistent concerns about their potentially adverse effect on fracture healing.AimTo assess whether NSAID exposure is a risk factor for fracture nonunion in children.MethodsWe systematically reviewed the literature reporting the effect of NSAIDs on bone healing. We included all clinical studies that reported on adverse bone healing complications in children with respect to NSAID exposure. The outcomes of interest were delayed union or nonunion. Study quality was assessed using the Newcastle-Ottawa scale for non-randomized studies. A final table was constructed summarizing the available evidence.ResultsA total of 120 articles were identified and screened, of which 6 articles were included for final review. Nonunion in children is extremely rare; among the studies included, there were 2011 nonunions among 238822 fractures (0.84%). None of the included studies documented an increased risk of nonunion or delayed bone healing in those children who are treated with NSAIDs in the immediate post-injury or peri-operative time period. Additionally, children are likely to take these medications for only a few days after injury or surgery, further decreasing their risk of adverse side-effects.ConclusionThis systematic review suggests that NSAIDS can be safely prescribed to pediatric orthopaedic patients absent other contraindications without concern for increased risk of fracture non-union or delayed bone healing. Additional prospective studies are needed focusing on higher risk fractures and elective orthopaedic procedures such as osteotomies and spinal fusion.

Published
2021

28. The Diagnostic Utility and Clinical Implications of Wrist MRI in the Pediatric Population.

Author

Gornitzky, Alex L., Lin, Ines C., and Carrigan, Robert B.

Abstract

Background: Unexplained wrist pain is a common presentation in children. To our knowledge, no studies have explored the clinical utility of magnetic resonance imaging (MRI) in the diagnostic workup of pediatric patients. Methods: We retrospectively reviewed 307 consecutive wrist MRIs ordered at a tertiary-care pediatric hospital. Demographic data and the indication for imaging were recorded and grouped into admitting categories. The final impression of each MRI was scored with regard to potential impact on future treatment (0 = normal, 1 = minimal, 2 = moderate, 3 = high). Patients who went on to wrist surgery within 1 year were noted. Results: In our cohort, 27% of all studies were normal, including 34% of those with pain. Although pain was the most common category, MRI was most useful in the delineation of a mass/cyst, evaluating for infection and evaluating arthropathy. Compared with all other categories, patients with pain were 3.6 times more likely to have a normal study and 4.6 times more likely to have a clinical score less than or equal to 1. Given an admitting diagnosis of pain, females were 1.7 times more likely to present for an MRI and 2.4 times more likely to have a normal MRI. The Spearman correlation revealed no linear relationship between age and MRI outcome. In all, 13% of patients went on to have surgery within 1 year of MRI. Conclusions: At our pediatric institution, the majority of wrist MRIs were ordered for wrist pain. Given our data, wrist MRI is not an ideal screening tool in children, particularly in those with wrist pain, and should only be used to exclude or confirm a specific diagnosis. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results