Search

Your search keyword '"Gorini, Francesca"' showing total 296 results
Start Over Author "Gorini, Francesca"
296 results on '"Gorini, Francesca"'

1. Targeting ATP2B1 impairs PI3K/Akt/FOXO signaling and reduces SARS-COV-2 infection and replication

Author

de Antonellis, Pasqualino, Ferrucci, Veronica, Miceli, Marco, Bibbo, Francesca, Asadzadeh, Fatemeh, Gorini, Francesca, Mattivi, Alessia, Boccia, Angelo, Russo, Roberta, Andolfo, Immacolata, Lasorsa, Vito Alessandro, Cantalupo, Sueva, Fusco, Giovanna, Viscardi, Maurizio, Brandi, Sergio, Cerino, Pellegrino, Monaco, Vittoria, Choi, Dong-Rac, Cheong, Jae-Ho, Iolascon, Achille, Amente, Stefano, Monti, Maria, Fava, Luca L, Capasso, Mario, Kim, Hong-Yeoul, and Zollo, Massimo

Published
2024
Full Text
View/download PDF

6. Vitamin C in the Management of Thyroid Cancer: A Highway to New Treatment?

Author

Gorini, Francesca and Tonacci, Alessandro

Subjects
ESSENTIAL nutrients, REACTIVE oxygen species, THYROID cancer, OXIDATIVE stress, STRESS management, VITAMIN C
Abstract

Thyroid cancer (TC) is the most common endocrine malignancy, with an increased global incidence in recent decades, despite a substantially unchanged survival. While TC has an excellent overall prognosis, some types of TC are associated with worse patient outcomes, depending on the genetic setting. Furthermore, oxidative stress is related to more aggressive features of TC. Vitamin C, an essential nutrient provided with food or as a dietary supplement, is a well-known antioxidant and a scavenger of reactive oxygen species; however, at high doses, it can induce pro-oxidant effects, acting through multiple biological mechanisms that play a crucial role in killing cancer cells. Although experimental data and, less consistently, clinical studies, suggest the possibility of antineoplastic effects of vitamin C at pharmacological doses, the antitumor efficacy of this nutrient in TC remains at least partly unexplored. Therefore, this review discusses the current state of knowledge on the role of vitamin C, alone or in combination with other conventional therapies, in the management of TC, the mechanisms underlying this association, and the perspectives that may emerge in TC treatment strategies, and, also, in light of the development of novel functional foods useful to this extent, by implementing novel sensory analysis strategies. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. Biochemical properties of chromatin domains define genome compartmentalization

Author

Lucini, Federica, primary, Petrini, Cristiano, additional, Salviato, Elisa, additional, Pal, Koustav, additional, Rosti, Valentina, additional, Gorini, Francesca, additional, Santarelli, Philina, additional, Quadri, Roberto, additional, Lembo, Giovanni, additional, Graziano, Giulia, additional, Di Patrizio Soldateschi, Emanuele, additional, Tagliaferri, Ilario, additional, Pinatel, Eva, additional, Sebestyén, Endre, additional, Rotta, Luca, additional, Gentile, Francesco, additional, Vaira, Valentina, additional, Lanzuolo, Chiara, additional, and Ferrari, Francesco, additional

Published
2024
Full Text
View/download PDF

9. Arbutus unedo L. Fractions Exhibit Chemotherapeutic Properties for the Treatment of Gastrointestinal Stromal Tumors

Author

Di Vito, Aldo, primary, Mandrone, Manuela, additional, Chiocchio, Ilaria, additional, Gorini, Francesca, additional, Ravegnini, Gloria, additional, Coschina, Emma, additional, Benuzzi, Eva, additional, Trincia, Simona, additional, Nozella, Augusto, additional, Aasen, Trond, additional, Sanna, Cinzia, additional, Morroni, Fabiana, additional, Hrelia, Patrizia, additional, Poli, Ferruccio, additional, and Angelini, Sabrina, additional

Published
2024
Full Text
View/download PDF

11. Hospital care in the first 10 years of life of children with congenital anomalies in six European countries:data from the EUROlinkCAT cohort linkage study

Author

Morris, Joan K, Loane, Maria, Wahlich, Charlotte, Tan, Joachim, Baldacci, Silvia, Ballardini, Elisa, Cavero-Carbonell, Clara, Damkjær, Mads, García-Villodre, Laura, Gissler, Mika, Given, Joanne, Gorini, Francesca, Heino, Anna, Limb, Elizabeth, Lutke, Renee, Neville, Amanda, Rissmann, Anke, Scanlon, Leuan, Tucker, David F, Urhoj, Stine Kjaer, de Walle, Hermien Ek, Garne, Ester, Morris, Joan K, Loane, Maria, Wahlich, Charlotte, Tan, Joachim, Baldacci, Silvia, Ballardini, Elisa, Cavero-Carbonell, Clara, Damkjær, Mads, García-Villodre, Laura, Gissler, Mika, Given, Joanne, Gorini, Francesca, Heino, Anna, Limb, Elizabeth, Lutke, Renee, Neville, Amanda, Rissmann, Anke, Scanlon, Leuan, Tucker, David F, Urhoj, Stine Kjaer, de Walle, Hermien Ek, and Garne, Ester

Abstract

OBJECTIVE: To quantify the hospital care for children born with a major congenital anomaly up to 10 years of age compared with children without a congenital anomaly.DESIGN, SETTING AND PATIENTS: 79 591 children with congenital anomalies and 2 021 772 children without congenital anomalies born 1995-2014 in six European countries in seven regions covered by congenital anomaly registries were linked to inpatient electronic health records up to their 10th birthday.MAIN OUTCOME MEASURES: Number of days in hospital and number of surgeries.RESULTS: During the first year of life among the seven regions, a median of 2.4% (IQR: 2.3, 3.2) of children with a congenital anomaly accounted for 18% (14, 24) of days in hospital and 63% (62, 76) of surgeries. Over the first 10 years of life, the percentages were 17% (15, 20) of days in hospital and 20% (19, 22) of surgeries. Children with congenital anomalies spent 8.8 (7.5, 9.9) times longer in hospital during their first year of life than children without anomalies (18 days compared with 2 days) and 5 (4.1-6.1) times longer aged, 5-9 (0.5 vs 0.1 days). In the first year of life, children with gastrointestinal anomalies spent 40 times longer and those with severe heart anomalies 20 times longer in hospital reducing to over 5 times longer when aged 5-9.CONCLUSIONS: Children with a congenital anomaly consume a significant proportion of hospital care resources. Priority should be given to public health primary prevention measures to reduce the risk of congenital anomalies.

Published
2024

12. Gorini, Francesca

Author

Gorini, Francesca and Gorini, Francesca

Published
2024

13. Metal Toxicity and Dementia Including Frontotemporal Dementia: Current State of Knowledge.

Author

Gorini, Francesca and Tonacci, Alessandro

Subjects
FRONTOTEMPORAL dementia, EXECUTIVE function, HEAVY metals, ARTIFICIAL intelligence, ENVIRONMENTAL risk
Abstract

Frontotemporal dementia (FTD) includes a number of neurodegenerative diseases, often with early onset (before 65 years old), characterized by progressive, irreversible deficits in behavioral, linguistic, and executive functions, which are often difficult to diagnose due to their similar phenotypic characteristics to other dementias and psychiatric disorders. The genetic contribution is of utmost importance, although environmental risk factors also play a role in its pathophysiology. In fact, some metals are known to produce free radicals, which, accumulating in the brain over time, can induce oxidative stress, inflammation, and protein misfolding, all of these being key features of FTD and similar conditions. Therefore, the present review aims to summarize the current evidence about the environmental contribution to FTD―mainly dealing with toxic metal exposure―since the identification of such potential environmental risk factors can lead to its early diagnosis and the promotion of policies and interventions. This would allow us, by reducing exposure to these pollutants, to potentially affect society at large in a positive manner, decreasing the burden of FTD and similar conditions on affected individuals and society overall. Future perspectives, including the application of Artificial Intelligence principles to the field, with related evidence found so far, are also introduced. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

16. miRNA levels are associated with body mass index in endometrial cancer and may have implications for therapy

Author

Ravegnini, Gloria, primary, Gorini, Francesca, additional, Coada, Camelia Alexandra, additional, De Leo, Antonio, additional, de Biase, Dario, additional, Di Costanzo, Stella, additional, De Crescenzo, Eugenia, additional, Coschina, Emma, additional, Monesmith, Sarah, additional, Bernante, Paolo, additional, Garelli, Silvia, additional, Balsamo, Francesca, additional, Hrelia, Patrizia, additional, De Iaco, Pierandrea, additional, Angelini, Sabrina, additional, and Perrone, Anna Myriam, additional

Published
2024
Full Text
View/download PDF

17. Supplementary Table S7 from Leveraging Tissue-Specific Enhancer–Target Gene Regulatory Networks Identifies Enhancer Somatic Mutations That Functionally Impact Lung Cancer

Author

Hariprakash, Judith Mary, primary, Salviato, Elisa, primary, La Mastra, Federica, primary, Sebestyén, Endre, primary, Tagliaferri, Ilario, primary, Silva, Raquel Sofia, primary, Lucini, Federica, primary, Farina, Lorenzo, primary, Cinquanta, Mario, primary, Rancati, Ilaria, primary, Riboni, Mirko, primary, Minardi, Simone Paolo, primary, Roz, Luca, primary, Gorini, Francesca, primary, Lanzuolo, Chiara, primary, Casola, Stefano, primary, and Ferrari, Francesco, primary

Published
2024
Full Text
View/download PDF

18. Supplementary Figures S1-S7 from Leveraging Tissue-Specific Enhancer–Target Gene Regulatory Networks Identifies Enhancer Somatic Mutations That Functionally Impact Lung Cancer

Author

Hariprakash, Judith Mary, primary, Salviato, Elisa, primary, La Mastra, Federica, primary, Sebestyén, Endre, primary, Tagliaferri, Ilario, primary, Silva, Raquel Sofia, primary, Lucini, Federica, primary, Farina, Lorenzo, primary, Cinquanta, Mario, primary, Rancati, Ilaria, primary, Riboni, Mirko, primary, Minardi, Simone Paolo, primary, Roz, Luca, primary, Gorini, Francesca, primary, Lanzuolo, Chiara, primary, Casola, Stefano, primary, and Ferrari, Francesco, primary

Published
2024
Full Text
View/download PDF

19. Data from Leveraging Tissue-Specific Enhancer–Target Gene Regulatory Networks Identifies Enhancer Somatic Mutations That Functionally Impact Lung Cancer

Author

Hariprakash, Judith Mary, primary, Salviato, Elisa, primary, La Mastra, Federica, primary, Sebestyén, Endre, primary, Tagliaferri, Ilario, primary, Silva, Raquel Sofia, primary, Lucini, Federica, primary, Farina, Lorenzo, primary, Cinquanta, Mario, primary, Rancati, Ilaria, primary, Riboni, Mirko, primary, Minardi, Simone Paolo, primary, Roz, Luca, primary, Gorini, Francesca, primary, Lanzuolo, Chiara, primary, Casola, Stefano, primary, and Ferrari, Francesco, primary

Published
2024
Full Text
View/download PDF

23. Hospital care in the first 10 years of life of children with congenital anomalies in six European countries: data from the EUROlinkCAT cohort linkage study.

Author

Morris, Joan K., Loane, Maria, Wahlich, Charlotte, Tan, Joachim, Baldacci, Silvia, Ballardini, Elisa, Cavero-Carbonell, Clara, Damkjær, Mads, García-Villodre, Laura, Gissler, Mika, Given, Joanne, Gorini, Francesca, Heino, Anna, Limb, Elizabeth, Lutke, Renee, Neville, Amanda, Rissmann, Anke, Scanlon, Leuan, Tucker, David F., and Urhoj, Stine Kjaer

Published
2024
Full Text
View/download PDF

24. Hypothyroidism in Patients with Down Syndrome: Prevalence and Association with Congenital Heart Defects.

Author

Gorini, Francesca, Coi, Alessio, Pierini, Anna, Assanta, Nadia, Bottoni, Antonio, and Santoro, Michele

Subjects
CONGENITAL heart disease, DOWN syndrome, MULTIPLE regression analysis, DISEASE prevalence, RETROSPECTIVE studies, DESCRIPTIVE statistics, ODDS ratio, CONFIDENCE intervals, DATA analysis software, CONGENITAL hypothyroidism, DISEASE risk factors
Abstract

This population-based study aimed to assess the prevalence of congenital hypothyroidism (CH) and overt hypothyroidism (OH) and their association with congenital heart defects (CHDs) in patients with Down syndrome (DS). The population included all live births residing in Tuscany (Italy) diagnosed with DS recorded in the Registry of Congenital Defects and in the Registry of Rare Diseases of Tuscany in the years 2003–2017. The prevalence of CH and OH in DS patients was calculated by sex and by period. The association of CH and OH with CHDs in DS patients was assessed using multivariate logistic regression. The cohort included 228 subjects. The prevalence of CH and OH was 11.4% (95%CI: 7.4–16.7%) and 12.7% (95%CI: 8.5–12.3%), respectively, with no significant difference by sex. A significant increase in the prevalence of CH (p < 0.0001) was found in the years 2010–2017 compared to the previous period, and among preterm infants (p = 0.009). The presence of CH was associated with a higher prevalence of CHDs (adjusted OR = 2.24, p = 0.082). A significant association between ventricular septal defects (VSDs) and the occurrence of OH (adjusted OR = 3.07, p = 0.025) was also observed. This study confirmed the higher prevalence of both CH and OH in DS compared to the general population. Furthermore, the risk of association between DS and CHDs was higher in the presence of CH, while VSDs are associated with OH, providing relevant insights into the epidemiology of hypothyroidism in DS and associated anomalies. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

27. Leveraging Tissue-Specific Enhancer–Target Gene Regulatory Networks Identifies Enhancer Somatic Mutations That Functionally Impact Lung Cancer

Author

Hariprakash, Judith Mary, primary, Salviato, Elisa, additional, La Mastra, Federica, additional, Sebestyén, Endre, additional, Tagliaferri, Ilario, additional, Silva, Raquel Sofia, additional, Lucini, Federica, additional, Farina, Lorenzo, additional, Cinquanta, Mario, additional, Rancati, Ilaria, additional, Riboni, Mirko, additional, Minardi, Simone Paolo, additional, Roz, Luca, additional, Gorini, Francesca, additional, Lanzuolo, Chiara, additional, Casola, Stefano, additional, and Ferrari, Francesco, additional

Published
2023
Full Text
View/download PDF

29. Bimodal CD40/Fas-Dependent Crosstalk between iNKT Cells and Tumor-Associated Macrophages Impairs Prostate Cancer Progression

Author

Cortesi, Filippo, Delfanti, Gloria, Grilli, Andrea, Calcinotto, Arianna, Gorini, Francesca, Pucci, Ferdinando, Lucianò, Roberta, Grioni, Matteo, Recchia, Alessandra, Benigni, Fabio, Briganti, Alberto, Salonia, Andrea, De Palma, Michele, Bicciato, Silvio, Doglioni, Claudio, Bellone, Matteo, Casorati, Giulia, and Dellabona, Paolo

Published
2018
Full Text
View/download PDF

30. Rationale and design of the CV-PREVITAL study: an Italian multiple cohort randomised controlled trial investigating innovative digital strategies in primary cardiovascular prevention

Author

Baldassarre, Damiano, primary, Iacoviello, Licia, additional, Baetta, Roberta, additional, Roncaglioni, Maria Carla, additional, Condorelli, Gianluigi, additional, Remuzzi, Giuseppe, additional, Gensini, Gianfranco, additional, Frati, Luigi, additional, Ricciardi, Walter, additional, Conaldi, Pier Giulio, additional, Uccelli, Antonio, additional, Blandini, Fabio, additional, Bosari, Silvano, additional, Scambia, Giovanni, additional, Fini, Massimo, additional, Di Malta, Antonio, additional, Amato, Mauro, additional, Veglia, Fabrizio, additional, Bonomi, Alice, additional, Klersy, Catherine, additional, Colazzo, Francesca, additional, Pengo, Martino, additional, Gorini, Francesca, additional, Auteri, Luciana, additional, Ferrante, Giuseppe, additional, Baviera, Marta, additional, Ambrosio, Giuseppe, additional, Catapano, Alberico, additional, Gialluisi, Alessandro, additional, Malavazos, Alexis Elias, additional, Castelvecchio, Serenella, additional, Corsi-Romanelli, Massimiliano Marco, additional, Cardani, Rosanna, additional, Rovere, Maria Teresa La, additional, Agnese, Valentina, additional, Pane, Bianca, additional, Prati, Daniele, additional, Spinardi, Laura, additional, Liuzzo, Giovanna, additional, Arbustini, Eloisa, additional, Volterrani, Maurizio, additional, Visconti, Marco, additional, Werba, José Pablo, additional, Genovese, Stefano, additional, Bilo, Grzegorz, additional, Invitti, Cecilia, additional, Di Blasio, Anna, additional, Lombardi, Carolina, additional, Faini, Andrea, additional, Rosa, Debora, additional, Ojeda-Fernández, Luisa, additional, Foresta, Andreana, additional, De Curtis, Amalia, additional, Di Castelnuovo, Augusto, additional, Scalvini, Simonetta, additional, Pierobon, Antonia, additional, Gorini, Alessandra, additional, Valenti, Luca, additional, Luzi, Livio, additional, Racca, Annarosa, additional, Bandi, Manuela, additional, Tremoli, Elena, additional, Menicanti, Lorenzo, additional, Parati, Gianfranco, additional, and Pompilio, Giulio, additional

Published
2023
Full Text
View/download PDF

33. Prescriptions for insulin and insulin analogues in children with and without major congenital anomalies:a data linkage cohort study across six European regions

Author

Given, Joanne, Morris, Joan K, Garne, Ester, Ballardini, Elisa, Barrachina-Bonet, Laia, Cavero-Carbonell, Clara, Gissler, Mika, Gorini, Francesca, Heino, Anna, Jordan, Sue, Neville, Amanda J, Pierini, Anna, Scanlon, Ieuan, Tan, Joachim, Urhoj, Stine K, Loane, Maria, Given, Joanne, Morris, Joan K, Garne, Ester, Ballardini, Elisa, Barrachina-Bonet, Laia, Cavero-Carbonell, Clara, Gissler, Mika, Gorini, Francesca, Heino, Anna, Jordan, Sue, Neville, Amanda J, Pierini, Anna, Scanlon, Ieuan, Tan, Joachim, Urhoj, Stine K, and Loane, Maria

Abstract

UNLABELLED: Are children with major congenital anomalies more likely to develop diabetes requiring insulin therapy, as indicated by prescriptions for insulin, than children without congenital anomalies? The aim of this study is to evaluate prescription rates of insulin/insulin analogues in children aged 0-9 years with and without major congenital anomalies. A EUROlinkCAT data linkage cohort study, involving six population-based congenital anomaly registries in five countries. Data on children with major congenital anomalies (60,662) and children without congenital anomalies (1,722,912), the reference group, were linked to prescription records. Birth cohort and gestational age were examined. The mean follow-up for all children was 6.2 years. In children with congenital anomalies aged 0-3 years, 0.04 per 100 child-years (95% CIs 0.01-0.07) had > 1 prescription for insulin/insulin analogues compared with 0.03 (95% CIs 0.01-0.06) in reference children, increasing ten-fold by age 8-9 years. The risk of > 1 prescription for insulin/insulin analogues aged 0-9 years in children with non-chromosomal anomalies (RR 0.92, 95% CI 0.84-1.00) was similar to that of reference children. However, children with chromosomal anomalies (RR 2.37, 95% CI 1.91-2.96), and specifically children with Down syndrome (RR 3.44, 95% CIs 2.70-4.37), Down syndrome with congenital heart defects (RR 3.86, 95% CIs 2.88-5.16) and Down syndrome without congenital heart defects (RR 2.78, 95% CIs 1.82-4.27), had a significantly increased risk of > 1 prescription for insulin/insulin analogues aged 0-9 years compared to reference children. Female children had a reduced risk of > 1 prescription aged 0-9 years compared with male children (RR 0.76, 95% CI 0.64-0.90 for children with congenital anomalies and RR 0.90, 95% CI 0.87-0.93 for reference children). Children without congenital anomalies born preterm (< 37 weeks) were more likely to have > 1 insulin/insulin analogue prescription compa

Published
2023

41. DDDR-32. A NEW IMMUNOMODULATORY FUNCTION OF PYRIDO-PYRIMIDINE DERIVATIVES TO IMPAIR METASTATIC GROUP 3 MEDULLOBLASTOMA IN VIVO

Author

Zollo, Massimo, primary, Asadzadeh, Fatemeh, additional, Ferrucci, Veronica, additional, De Antonellis, Pasqualino, additional, Bibbò, Francesca, additional, Siciliano, Roberto, additional, Sorice, Carmen, additional, Criscuolo, Giuseppina, additional, Filiz, Dalim Kardelen, additional, Tecik, Melisa, additional, Amente, Stefano, additional, Saccà, Carmen Daniela, additional, Gorini, Francesca, additional, Pedone, Emilia, additional, Diana, Donatella, additional, Pirone, Luciano, additional, Fattorusso, Roberto, additional, Navas, Luigi, additional, Donofrio, Vittoria, additional, Errico, Maria Elena, additional, Spennato, Pietro, additional, De Martino, Lucia, additional, Quaglietta, Lucia, additional, Tirone, Felice, additional, and Cinalli, Giuseppe, additional

Published
2022
Full Text
View/download PDF

43. OxiDIP-Seq for Genome-wide Mapping of Damaged DNA Containing 8-Oxo-2'-Deoxyguanosine

Author

Gorini, Francesca, Scala, Giovanni, Ambrosio, Susanna, Majello, Barbara, Amente, Stefano, Gorini, Francesca, Scala, Giovanni, Ambrosio, Susanna, Majello, Barbara, and Amente, Stefano

Subjects
8-oxo-7,8-dihydro-2′-deoxyguanosine, 8-oxodG, DNA oxidation, DNA damage, OxiDIP-Seq
Abstract

8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) is considered to be a premutagenic DNA lesion generated by 2'-deoxyguanosine (dG) oxidation due to reactive oxygen species (ROS). In recent years, the 8-oxodG distribution in human, mouse, and yeast genomes has been underlined using various next-generation sequencing (NGS)–based strategies. The present study reports the OxiDIP-Seq protocol, which combines specific 8-oxodG immuno-precipitation of single-stranded DNA with NGS, and the pipeline analysis that allows the genome-wide 8-oxodG distribution in mammalian cells. The development of this OxiDIP-Seq method increases knowledge on the oxidative DNA damage/repair field, providing a high-resolution map of 8-oxodG in human cells.

Published
2022

45. Targeting ATP2B1 impairs PI3K/Akt/Fox-O3 signaling and reduces SARS-COV-2 replication in vivo

Author

de Antonellis, Pasqualino, primary, Ferrucci, Veronica, additional, Bibbo, Francesca, additional, Asadzadeh, Fathemeh, additional, Gorini, Francesca, additional, Boccia, Angelo, additional, Sorice, Carmen, additional, Siciliano, Roberto, additional, Russo, Roberta, additional, Andolfo, Immacolata, additional, Lasorsa, Vito Alessandro, additional, Cantalupo, Sueva, additional, Paolella, Giovanni, additional, Fusco, Giovanna, additional, Viscardi, Maurizio, additional, Brandi, Sergio, additional, Pierri, Bianca Maria, additional, Cerino, Pellegrino, additional, Monaco, Vittoria, additional, choi, Dong-Rac, additional, Cheong, Jae-Ho, additional, Monti, Maria, additional, Iolascon, Achille, additional, Amente, Stefano, additional, Capasso, Mario, additional, Kim, Hong-Yeoul, additional, and Zollo, Massimo, additional

Published
2022
Full Text
View/download PDF

47. Prescriptions for insulin and insulin analogues in children with and without major congenital anomalies: A data linkage cohort study across six European regions

Author

Given, Joanne, primary, Morris, Joan K., additional, Garne, Ester, additional, Ballardini, Elisa, additional, Barrachina-Bonet, Laia, additional, Cavero-Carbonell, Clara, additional, Gissler, Mika, additional, Gorini, Francesca, additional, Heino, Anna, additional, Jordan, Sue, additional, Neville, Amanda J., additional, Pierini, Anna, additional, Scanlon, Ieuan, additional, Tan, Joachim, additional, Urhoj, Stine K., additional, and Loane, Maria, additional

Published
2022
Full Text
View/download PDF

48. Risk Factors for Lung Cancer in the Province of Lecce: Results from the PROTOS Case–Control Study in Salento (Southern Italy)

Author

Minichilli, Fabrizio, primary, Gorini, Francesca, additional, De Filippis, Giovanni, additional, Bustaffa, Elisa, additional, Raho, Anna Maria, additional, Melcarne, Anna, additional, Quarta, Fabrizio, additional, Maggiore, Giuseppe, additional, Idolo, Adele, additional, Serio, Francesca, additional, Grassi, Tiziana, additional, Bagordo, Francesco, additional, Castorini, Idelberto Francesco, additional, Imbriani, Giovanni, additional, Bianchi, Fabrizio, additional, and Piscitelli, Prisco, additional

Published
2022
Full Text
View/download PDF

49. Vitamin D Determinants, Status, and Antioxidant/Anti-inflammatory-Related Effects in Cardiovascular Risk and Disease: Not the Last Word in the Controversy.

Author

Della Nera, Giulia, Sabatino, Laura, Gaggini, Melania, Gorini, Francesca, and Vassalle, Cristina

Subjects
VITAMIN D, CARDIOVASCULAR diseases risk factors, CARDIOVASCULAR diseases
Abstract

Beyond its key role in calcium homeostasis, vitamin D has been found to significantly affect the cardiovascular (CV) system. In fact, low vitamin D levels have been associated with increased CV risk, as well as increased CV morbidity and mortality. The majority of effects of this molecule are related directly or indirectly to its antioxidative and anti-inflammatory properties. Generally, vitamin D insufficiency is considered for 25-hydroxyvitamin D (25(OH)D) levels between 21–29 ng/mL (corresponding to 52.5–72.5 nmol/L), deficiency as 25(OH)D levels less than 20 ng/mL (<50 nmol/L), and extreme deficiency as 25(OH)D less than 10 ng/mL (<25 nmol/L). However, the definition of an optimal vitamin D status, as defined by 25(OH)D, remains controversial for many extra-bone conditions, including CV disease. In this review, confounding factors affecting the 25(OH)D measurement and status will be discussed. In particular, available evidence on the mechanism and role of vitamin D in relation to CV risk and disease through its antioxidant effect will be reported, also facing the aspect regarding the debate on the minimum blood 25(OH)D level required to ensure optimal CV health. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results