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14 results on '"Gorelkin, Peter V."'

1. Variation in tumor pH affects pH-triggered delivery of peptide-modified magnetic nanoparticles

Author

Pershina, Alexandra G., Brikunova, Olga Ya., Demin, Alexander M., Abakumov, Maxim A., Vaneev, Alexander N., Naumenko, Victor A., Erofeev, Alexander S., Gorelkin, Peter V., Nizamov, Timur R., Muslimov, Albert R., Timin, Alexander S., Malkeyeva, Dina, Kiseleva, Elena, Vtorushin, Sergey V., Larionova, Irina V., Gereng, Elena A., Minin, Artem S., Murzakaev, Aidar M., Krasnov, Victor P., Majouga, Alexander G., and Ogorodova, Ludmila M.

Published
2021
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2. Temperature-controlled magnetic nanoparticles hyperthermia inhibits primary tumor growth and metastases dissemination

Author

Garanina, Anastasiia S., Naumenko, Victor A., Nikitin, Aleksey A., Myrovali, Eirini, Petukhova, Anna Y., Klimyuk, Svetlana V., Nalench, Yulia A., Ilyasov, Artem R., Vodopyanov, Stepan S., Erofeev, Alexander S., Gorelkin, Peter V., Angelakeris, Makis, Savchenko, Alexander G., Wiedwald, Ulf, Majouga Dr, Alexander G., and Abakumov, Maxim A.

Published
2020
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4. Inhibition of Self-Assembling Peptide Fibrils Formation Using Thioflavin T as a Photosensitizer

Author

Tikhonova, Tatiana N., primary, Rubekina, Anna A., additional, Vorobev, Viktor A., additional, Mefodeva, Ekaterina A., additional, Maksimov, Eugene G., additional, Efremov, Yuri M., additional, Darvin, Maxim E., additional, Timashev, Peter S., additional, Gorelkin, Peter V., additional, Erofeev, Alexander S., additional, Sysoev, Nikolay N., additional, and Shirshin, Evgeny A., additional

Published
2023
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5. Bifunctional Magnetite–Gold Nanoparticles for Magneto-Mechanical Actuation and Cancer Cell Destruction

Author

Garanina, Anastasiia S., primary, Efremova, Maria V., additional, Machulkin, Alexey E., additional, Lyubin, Evgeny V., additional, Vorobyeva, Natalia S., additional, Zhironkina, Oxana A., additional, Strelkova, Olga S., additional, Kireev, Igor I., additional, Alieva, Irina B., additional, Uzbekov, Rustem E., additional, Agafonov, Viatcheslav N., additional, Shchetinin, Igor V., additional, Fedyanin, Andrey A., additional, Erofeev, Alexander S., additional, Gorelkin, Peter V., additional, Korchev, Yuri E., additional, Savchenko, Alexander G., additional, and Abakumov, Maxim A., additional

Published
2022
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6. Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity

Author

Garanina, Anastasiia S., Nikitin, Alexey A., Abakumova, Tatiana O., Semkina, Alevtina S., Prelovskaya, Alexandra O., Naumenko, Victor A., Erofeev, Alexander S., Gorelkin, Peter V., Majouga, Alexander G., Abakumov, Maxim A., and Wiedwald, Ulf

Subjects
Chemistry, Forschungszentren » Center for Nanointegration Duisburg-Essen (CENIDE), cobalt ferrite nanoparticles -- biocompatibility -- magnetic properties -- controlled magnetic hyperthermia -- tumor therapy, biocompatibility, ddc:530, controlled magnetic hyperthermia, magnetic properties, Physik (inkl. Astronomie), tumor therapy, cobalt ferrite nanoparticles, QD1-999
Abstract

OA Förderung 2021 Magnetic nanoparticles (MNPs) are widely considered for cancer treatment, in particular for magnetic hyperthermia (MHT). Thereby, MNPs are still being optimized for lowest possible toxicity on organisms while the magnetic properties are matched for best heating capabilities. In this study, the biocompatibility of 12 nm cobalt ferrite MNPs, functionalized with citrate ions, in different dosages on mice and rats of both sexes was investigated for 30 days after intraperitoneal injection. The animals’ weight, behavior, and blood cells changes, as well as blood biochemical parameters are correlated to histological examination of organs revealing that cobalt ferrite MNPs do not have toxic effects at concentrations close to those used previously for efficient MHT. Moreover, these MNPs demonstrated high specific loss power (SLP) of about 400 W g−1. Importantly the MNPs retained their magnetic properties inside tumor tissue after intratumoral administration for several MHT cycles within three days. Thus, cobalt ferrite MNPs represent a perspective platform for tumor therapy by MHT due to their ability to provide effective heating without exerting a toxic effect on the organism. This opens up new avenues for smaller MNPs sizes while their heating efficiency is maintained.

Published
2022

7. Pitstop‐2 and its novel derivative RVD ‐127 disrupt global cell dynamics and nuclear pores integrity by direct interaction with small GTPases

Author

Liashkovich, Ivan, primary, Stefanello, Sílvio Terra, additional, Vidyadharan, Reshma, additional, Haufe, Günter, additional, Erofeev, Alexander, additional, Gorelkin, Peter V., additional, Kolmogorov, Vasilii, additional, Mizdal, Caren Rigon, additional, Dulebo, Alexander, additional, Bulk, Etmar, additional, Kouzel, Ian U., additional, and Shahin, Victor, additional

Published
2022
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8. Pitstop‐2 and its novel derivative RVD‐127 disrupt global cell dynamics and nuclear pores integrity by direct interaction with small GTPases.

Author

Liashkovich, Ivan, Stefanello, Sílvio Terra, Vidyadharan, Reshma, Haufe, Günter, Erofeev, Alexander, Gorelkin, Peter V., Kolmogorov, Vasilii, Mizdal, Caren Rigon, Dulebo, Alexander, Bulk, Etmar, Kouzel, Ian U., and Shahin, Victor

Subjects
NUCLEAR transport (Cytology), NUCLEOCYTOPLASMIC interactions, CELL motility, MOLECULAR switches, DRUG development, PHYSIOLOGY
Abstract

Clathrin‐mediated endocytosis (CME) is an essential cell physiological process of broad biomedical relevance. Since the recent introduction of Pitstop‐2 as a potent CME inhibitor, we and others have reported on substantial clathrin‐independent inhibitory effects. Herein, we developed and experimentally validated a novel fluorescent derivative of Pitstop‐2, termed RVD‐127, to clarify Pitstop‐2 diverse effects. Using RVD‐127, we were able to trace additional protein targets of Pitstop‐2. Besides inhibiting CME, Pitstop‐2 and RVD‐127 proved to directly and reversibly bind to at least two members of the small GTPase superfamily Ran and Rac1 with particularly high efficacy. Binding locks the GTPases in a guanosine diphosphate (GDP)‐like conformation disabling their interaction with their downstream effectors. Consequently, overall cell motility, mechanics and nucleocytoplasmic transport integrity are rapidly disrupted at inhibitor concentrations well below those required to significantly reduce CME. We conclude that Pitstop‐2 is a highly potent, reversible inhibitor of small GTPases. The inhibition of these molecular switches of diverse crucial signaling pathways, including nucleocytoplasmic transport and overall cell dynamics and motility, clarifies the diversity of Pitstop‐2 activities. Moreover, considering the fundamental importance and broad implications of small GTPases in physiology, pathophysiology and drug development, Pitstop‐2 and RVD‐127 open up novel avenues. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Antifungal Thiazolidines: Synthesis and Biological Evaluation of Mycosidine Congeners

Author

Levshin, Igor B., primary, Simonov, Alexander Y., additional, Lavrenov, Sergey N., additional, Panov, Alexey A., additional, Grammatikova, Natalia E., additional, Alexandrov, Alexander A., additional, Ghazy, Eslam S. M. O., additional, Savin, Nikita A., additional, Gorelkin, Peter V., additional, Erofeev, Alexander S., additional, and Polshakov, Vladimir I., additional

Published
2022
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10. Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity

Author

Garanina, Anastasiia S., primary, Nikitin, Alexey A., additional, Abakumova, Tatiana O., additional, Semkina, Alevtina S., additional, Prelovskaya, Alexandra O., additional, Naumenko, Victor A., additional, Erofeev, Alexander S., additional, Gorelkin, Peter V., additional, Majouga, Alexander G., additional, Abakumov, Maxim A., additional, and Wiedwald, Ulf, additional

Published
2021
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12. Synthesis and Evaluation of New Trivalent Ligands for Hepatocyte Targeting via the Asialoglycoprotein Receptor

Author

Reshitko, Galina S., primary, Yamansarov, Emil Yu., additional, Evteev, Sergei A., additional, Lopatukhina, Elena V., additional, Shkil’, Dmitry O., additional, Saltykova, Irina V., additional, Lopukhov, Anton V., additional, Kovalev, Sergey V., additional, Lobov, Alexander N., additional, Kislyakov, Ivan V., additional, Burenina, Olga Yu., additional, Klyachko, Natalia L., additional, Garanina, Anastasiia S., additional, Dontsova, Olga A., additional, Ivanenkov, Yan A., additional, Erofeev, Alexander S., additional, Gorelkin, Peter V., additional, Beloglazkina, Elena K., additional, and Majouga, Alexander G., additional

Published
2020
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14. Conditioning adhesive contacts between the neutrophils and the endotheliocytes by Staphylococcus aureus.

Author

Pleskova, Svetlana N., Kriukov, Ruslan N., Bobyk, Sergey Z., Boryakov, Alexey V., Gorelkin, Peter V., and Erofeev, Alexander S.

Subjects
STAPHYLOCOCCUS aureus, ENDOTHELIAL cells, ADHESION, LABOR supply
Abstract

We have developed a model for evaluating the integral intercellular interactions in the "endotheliocyte‐neutrophil" system and have shown the high variability of adhesion contacts in different donors associated with different expression profiles of neutrophils. Two methods (forсe spectroscopy‐spectroscopy and scanning ion‐conductance microscopy) showed a decrease in the rigidity of the membrane‐cytoskeletal complex of neutrophils under the influence of Staphylococcus aureus 2879 M. Adding this strain to the "endotheliocyte‐neutrophil" system caused a statistically significant decrease in the adhesion force and adhesion work, which indicates a change in the expression profile and physicochemical properties of membranes of both types of interacting cells (neutrophils and endotheliocytes). [ABSTRACT FROM AUTHOR]

Published
2020
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