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164 results on '"Gordon, Adam S."'

1. Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations

Author

Lennon, Niall J., Kottyan, Leah C., Kachulis, Christopher, Abul-Husn, Noura S., Arias, Josh, Belbin, Gillian, Below, Jennifer E., Berndt, Sonja I., Chung, Wendy K., Cimino, James J., Clayton, Ellen Wright, Connolly, John J., Crosslin, David R., Dikilitas, Ozan, Velez Edwards, Digna R., Feng, QiPing, Fisher, Marissa, Freimuth, Robert R., Ge, Tian, Glessner, Joseph T., Gordon, Adam S., Patterson, Candace, Hakonarson, Hakon, Harden, Maegan, Harr, Margaret, Hirschhorn, Joel N., Hoggart, Clive, Hsu, Li, Irvin, Marguerite R., Jarvik, Gail P., Karlson, Elizabeth W., Khan, Atlas, Khera, Amit, Kiryluk, Krzysztof, Kullo, Iftikhar, Larkin, Katie, Limdi, Nita, Linder, Jodell E., Loos, Ruth J. F., Luo, Yuan, Malolepsza, Edyta, Manolio, Teri A., Martin, Lisa J., McCarthy, Li, McNally, Elizabeth M., Meigs, James B., Mersha, Tesfaye B., Mosley, Jonathan D., Musick, Anjene, Namjou, Bahram, Pai, Nihal, Pesce, Lorenzo L., Peters, Ulrike, Peterson, Josh F., Prows, Cynthia A., Puckelwartz, Megan J., Rehm, Heidi L., Roden, Dan M., Rosenthal, Elisabeth A., Rowley, Robb, Sawicki, Konrad Teodor, Schaid, Daniel J., Smit, Roelof A. J., Smith, Johanna L., Smoller, Jordan W., Thomas, Minta, Tiwari, Hemant, Toledo, Diana M., Vaitinadin, Nataraja Sarma, Veenstra, David, Walunas, Theresa L., Wang, Zhe, Wei, Wei-Qi, Weng, Chunhua, Wiesner, Georgia L., Yin, Xianyong, and Kenny, Eimear E.

Published
2024
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3. Prospective, multi-site study of healthcare utilization after actionable monogenic findings from clinical sequencing

Author

Linder, Jodell E., Tao, Ran, Chung, Wendy K., Kiryluk, Krzysztof, Liu, Cong, Weng, Chunhua, Connolly, John J., Hakonarson, Hakon, Harr, Margaret, Leppig, Kathleen A., Jarvik, Gail P., Veenstra, David L., Aufox, Sharon, Chisholm, Rex L., Gordon, Adam S., Hoell, Christin, Rasmussen-Torvik, Laura J., Smith, Maureen E., Holm, Ingrid A., Miller, Erin M., Prows, Cynthia A., Elskeally, Omar, Kullo, Iftikhar J., Lee, Christopher, Jose, Sheethal, Manolio, Teri A., Rowley, Robb, Padi-Adjirackor, Nana Addo, Wilmayani, Ni Ketut, City, Brittany, Wei, Wei-Qi, Wiesner, Georgia L., Rahm, Alanna Kulchak, Williams, Janet L., Williams, Marc S., and Peterson, Josh F.

Published
2023
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5. Returning integrated genomic risk and clinical recommendations: The eMERGE study

Author

Gordon, Adam, Sobowale, Agboade, Allworth, Aimee, Patel, Akshar, DiVietro, Alanna, Strong, Alanna, Sherafati, Alborz, Sherfati, Alborz, Bick, Alex, Miller, Alexandra, Chandel, Alka, Rosenthal, Alyssa, Khera, Amit, Kontorovich, Amy, Beck, Andrew, Beck, Andy, Espinoza, Angelica, Lewis, Anna, Prince, Anya, Khan, Atlas, Iverson, Ayuko, Khales, Bahram Namjou, Benoit, Barbara, Hernan, Becca, Kallman, Ben, Kerman, Ben, Shoemaker, Ben, Satterfield, Benjamin, Devine, Beth, Etheridge, Bethany, Goff, Blake, Freimuth, Bob, Grundmeier, Bob, Collier, Brenae, Mutai, Brenda, Harnett, Brett, Chang, Brian, Piening, Brian, Davis, Brittney, Korf, Bruce, Patterson, Candace, Demetriou, Carmen, Ta, Casey, Hammack, Catherine, Nelson, Catrina, Gascoigne, Caytie, Dorn, Chad, Moretz, Chad, Kachulis, Chris, Hoell, Christie, Cowles, Christine, Lange, Christoph, Weng, Chunhua, Prows, Cindy, Brokamp, Cole, Liu, Cong, Scherr, Courtney, Gonzalez, Crystal, Ramirez, Cynthia, Shimbo, Daichi, Roden, Dan, Schaid, Daniel, Kaufman, Dave, Crosslin, David, Kochan, David, Veenstra, David, Singh, Davinder, Karavite, Dean, Abrams, Debbie, Absher, Devin, Edwards, Digna Velez, Haverfield, Eden, Morales, Eduardo, Esplin, Edward, Malolepsza, Edyta, Alipour, Ehsan, Kenny, Eimear, Rosenthal, Elisabeth, Duvall, Eliza, McNally, Elizabeth, Bhoj, Elizabeth, Cohn, Elizabeth, Hibler, Elizabeth, Karlson, Elizabeth, Clayton, Ellen, Chesnut, Emily, DeFranco, Emily, Gallagher, Emily, Soper, Emily, Perez, Emma, Cash, Erin, Berner, Eta, Wang, Fei, Wehbe, Firas, Ricci, Francisco, Mentch, Frank, Shaibi, Gabriel, Jarvik, Gail, Hahn, George, Hripcsak, George, Wiesner, Georgia, Belbin, Gillian, Davogustto, Gio, Nadkarni, Girish, Qiu, Haijun, Hakonarson, Hakon, Bangash, Hana, Beasley, Hannah, Liu, Hao, Aungst, Heide, Tiwari, Hemant, Duckham, Hillary, Thomas, Hope, Kullo, Iftikhar, Holm, Ingrid, Allen, Isabelle, Ionita-Laza, Iuliana, Hellwege, Jacklyn, Petrzelka, Jacob, Odgis, Jacqueline, Narula, Jahnavi, Petrzelka, Jake, Patel, Jalpa, Cimino, James, Meigs, James, Snyder, James, Olson, Janet, Zahner, Janet, Pennington, Jeff, Pacheco, Jen, Pacheco, Jennifer Allen, Morse, Jennifer, Corsmo, Jeremy, Thayer, Jeritt, Cimino, Jim, Chen, Jingheng, Fournier, Jocelyn, Jackson, Jodell, Glessner, Joe, Pacyna, Joel, Smith, Johanna, Connolly, John, Lynch, John, Shelley, John, Mosley, Jonathan, Nestor, Jordan, Smoller, Jordan, Alsip, Jorge, Kannry, Joseph, Sutton, Joseph, Peterson, Josh, Smith, Joshua, Galasso, Julia, Smith, Julia, Wynn, Julia, Gundelach, Justin, Starren, Justin, Choi, Karmel, Mittendorf, Kate, Anderson, Katherine, Bonini, Katherine, Leppig, Kathleen, Muenzen, Kathleen, Larkin, Katie, Stuttgen, Kelsey, Wiley, Ken, Nguyen, Kenny, Dufendach, Kevin, Atkins, Kiley, Sawicki, Konrad, Norland, Kristjan, Kiryluk, Krzysztof, Beskow, Laura, Rasmussen-Torvik, Laura, Kottyan, Leah, Hsu, Li, Tian, Lifeng, Mahanta, Lisa, Martin, Lisa, Wang, Lisa, Gomez, Lizbeth, Thompson, Lorenzo, Orlando, Lori, Richter, Lucas, Rasmussen, Luke, Petukhova, Lynn, Seabolt, Lynn, O’Brien, Madison, Harden, Maegan, Fullerton, Malia, Harr, Margaret, Beasley, Mark, Guindo, Marta, Horike, Martha, Horike-Pyne, Martha, Abdalla, Marwah, Hamed, Marwan, Terry, Mary Beth, Maradik, Mary, Wyatt, Matt, Davis, Matthew, Lebo, Matthew, Smith, Maureen, Rosario, Maya del, Sabatello, Maya, Behr, Meckenzie, Roy-Puckelwartz, Meg, Habrat, Mel, Myers, Melanie, Yetisgen, Meliha, Iris, Merve, DaSilva, Michael, Preuss, Michael, McGowan, Michelle, Shi, Mingjian, Perera, Minoli, Thomas, Minta, Elkind, Mitch, Abbass, Mohammad, Saadatagah, Mohammad, Hess, Molly, Maradik, Molly, Vaitinadin, Nataraja “RJ”, Vaitinadin, Nataraja, Muthu, Naveen, Netherly, Neil, Lennon, Niall, Shang, Ning, Limdi, Nita, Forrest, Noah, Romero, Noheli, Robinson, Nora, Abul-Husn, Noura, Elsekaily, Omar, Dikilitas, Ozan, Kovatch, Patricia, Davis, Patrick, Appelbaum, Paul, Francaviglia, Paul, O’Reilly, Paul, Chandler, Paulette, Caraballo, Pedro, Tarczy-Hornoch, Peter, Shum, Pierre, Marathe, Priya, Murali, Priyanka, Feng, Qiping, Wells, Quinn, Atchley, Rachel, Narla, Radhika, Barton, Rene, Sterling, Rene, Chisholm, Rex, Green, Richard, Sharp, Richard, Peters, Riki, Kukafka, Rita, Rowley, Robb, Freimuth, Robert, Green, Robert, Winter, Robert, Mueller, Roger, Loos, Ruth, Irvin, Ryan, Suckiel, Sabrina, Hussain, Sajjad, Sharba, Samer, Aronson, Sandy, Jones, Sarah, Knerr, Sarah, Nigbur, Scott, Weiss, Scott, Mooney, Sean, Terek, Shannon, Aufox, Sharon, Nirenberg, Sharon, Murphy, Shawn, O’Byrne, Sheila, Wang (Sam) Choi, Shing, Aguilar, Sienna, Bland, S.T., Rodrigues, Stefanie, Ledbetter, Stephanie, Rutledge, Stephanie, Booth, Stuart James, Xian, Su, Trinidad, Susan Brown, Bakken, Suzanne, Schmidlen, Tara, Rakhra-Burris, Tejinder, Manolio, Teri, Mersha, Tesfaye, Walunas, Theresa, Chandereng, Thevaa, May, Thomas, Ge, Tian, Edwards, Todd, Kaszemacher, Tom, Hernandez, Valentina, Willis, Valerie, Desai, Vemi, Desai, Vimi, Lorenzi, Virginia, Gainer, Vivian, Wei, Wei-Qi, Chung, Wendy, Su, Wu-Chen, Chang, Xiao, Zhao, Yiqing, Luo, Yuan, Shen, Yufeng, Linder, Jodell E., Bland, Sarah T., Caraballo, Pedro J., Chisholm, Rex L., Clayton, Ellen Wright, Crosslin, David R., Esplin, Edward D., Forman, Sophie, Freimuth, Robert R., Gordon, Adam S., Harden, Maegan V., Holm, Ingrid A., Jarvik, Gail P., Karlson, Elizabeth W., Labrecque, Sofia, Lennon, Niall J., Limdi, Nita A., Mittendorf, Kathleen F., Murphy, Shawn N., Prows, Cynthia A., Rasmussen, Luke V., Sawicki, Konrad Teodor, Velez Edwards, Digna R., Abul-Husn, Noura S., Below, Jennifer E., Berner, Eta S., Booth, James, Chung, Wendy K., Cimino, James J., Fullerton, Stephanie M., Guiducci, Candace, Habrat, Melissa L., Hain, Heather, Hoell, Christin, Irvin, Marguerite R., Kachulis, Christopher, Kenny, Eimear E., Kullo, Iftikhar J., Manolio, Teri A., McNally, Elizabeth M., Mooney, Sean D., Namjou, Bahram, Perez, Emma F., Puckelwartz, Megan J., Roden, Dan M., Rosenthal, Elisabeth A., Saadatagah, Seyedmohammad, Schaid, Dan J., Schultz, Baergen, Shaibi, Gabriel Q., Sharp, Richard R., Shirts, Brian, Smith, Maureen E., Smoller, Jordan W., Suckiel, Sabrina A., Tiwari, Hemant K., Trinidad, Susan B., Wells, Quinn S., Wiesner, Georgia L., and Peterson, Josh F.

Published
2023
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6. Large-scale genome-wide association study of coronary artery disease in genetically diverse populations

Author

Tcheandjieu, Catherine, Zhu, Xiang, Hilliard, Austin T., Clarke, Shoa L., Napolioni, Valerio, Ma, Shining, Lee, Kyung Min, Fang, Huaying, Chen, Fei, Lu, Yingchang, Tsao, Noah L., Raghavan, Sridharan, Koyama, Satoshi, Gorman, Bryan R., Vujkovic, Marijana, Klarin, Derek, Levin, Michael G., Sinnott-Armstrong, Nasa, Wojcik, Genevieve L., Plomondon, Mary E., Maddox, Thomas M., Waldo, Stephen W., Bick, Alexander G., Pyarajan, Saiju, Huang, Jie, Song, Rebecca, Ho, Yuk-Lam, Buyske, Steven, Kooperberg, Charles, Haessler, Jeffrey, Loos, Ruth J. F., Do, Ron, Verbanck, Marie, Chaudhary, Kumardeep, North, Kari E., Avery, Christy L., Graff, Mariaelisa, Haiman, Christopher A., Le Marchand, Loïc, Wilkens, Lynne R., Bis, Joshua C., Leonard, Hampton, Shen, Botong, Lange, Leslie A., Giri, Ayush, Dikilitas, Ozan, Kullo, Iftikhar J., Stanaway, Ian B., Jarvik, Gail P., Gordon, Adam S., Hebbring, Scott, Namjou, Bahram, Kaufman, Kenneth M., Ito, Kaoru, Ishigaki, Kazuyoshi, Kamatani, Yoichiro, Verma, Shefali S., Ritchie, Marylyn D., Kember, Rachel L., Baras, Aris, Lotta, Luca A., Kathiresan, Sekar, Hauser, Elizabeth R., Miller, Donald R., Lee, Jennifer S., Saleheen, Danish, Reaven, Peter D., Cho, Kelly, Gaziano, J. Michael, Natarajan, Pradeep, Huffman, Jennifer E., Voight, Benjamin F., Rader, Daniel J., Chang, Kyong-Mi, Lynch, Julie A., Damrauer, Scott M., Wilson, Peter W. F., Tang, Hua, Sun, Yan V., Tsao, Philip S., O’Donnell, Christopher J., and Assimes, Themistocles L.

Published
2022
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7. Neptune: an environment for the delivery of genomic medicine

Author

Eric, Venner, Yi, Victoria, Murdock, David, Kalla, Sara E., Wu, Tsung-Jung, Sabo, Aniko, Li, Shoudong, Meng, Qingchang, Tian, Xia, Murugan, Mullai, Cohen, Michelle, Kovar, Christie, Wei, Wei-Qi, Chung, Wendy K., Weng, Chunhua, Wiesner, Georgia L., Jarvik, Gail P., Muzny, Donna, Gibbs, Richard A., Abrams, Debra, Adunyah, Samuel E., Albertson-Junkans, Ladia, Almoguera, Berta, Ames, Darren C., Appelbaum, Paul, Aronson, Samuel, Aufox, Sharon, Babb, Lawrence J., Balasubramanian, Adithya, Bangash, Hana, Basford, Melissa, Bastarache, Lisa, Baxter, Samantha, Behr, Meckenzie, Benoit, Barbara, Bhoj, Elizabeth, Bielinski, Suzette J., Bland, Harris T., Blout, Carrie, Borthwick, Kenneth, Bottinger, Erwin P., Bowser, Mark, Brand, Harrison, Brilliant, Murray, Brodeur, Wendy, Caraballo, Pedro, Carrell, David, Carroll, Andrew, Castillo, Lisa, Castro, Victor, Chandanavelli, Gauthami, Chiang, Theodore, Chisholm, Rex L., Christensen, Kurt D., Chung, Wendy, Chute, Christopher G., City, Brittany, Cobb, Beth L., Connolly, John J., Crane, Paul, Crew, Katherine, Crosslin, David R., Dayal, Jyoti, De Andrade, Mariza, De la Cruz, Jessica, Denny, Josh C., Denson, Shawn, DeSmet, Tim, Dikilitas, Ozan, Dinsmore, Michael J., Dodge, Sheila, Dunlea, Phil, Edwards, Todd L., Eng, Christine M., Fasel, David, Fedotov, Alex, Feng, Qiping, Fleharty, Mark, Foster, Andrea, Freimuth, Robert, Friedrich, Christopher, Fullerton, Stephanie M., Funke, Birgit, Gabriel, Stacey, Gainer, Vivian, Gharavi, Ali, Glazer, Andrew M., Glessner, Joseph T., Goehringer, Jessica, Gordon, Adam S., Graham, Chet, Green, Robert C., Gundelach, Justin H., Hain, Heather S., Hakonarson, Hakon, Harden, Maegan V., Harley, John, Harr, Margaret, Hartzler, Andrea, Hayes, M. Geoffrey, Hebbring, Scott, Henrikson, Nora, Hershey, Andrew, Hoell, Christin, Holm, Ingrid, Howell, Kayla M., Hripcsak, George, Hu, Jianhong, Hynes, Elizabeth Duffy, Jayaseelan, Joy C., Jiang, Yunyun, Joo, Yoonjung Yoonie, Jose, Sheethal, Josyula, Navya Shilpa, Justice, Anne E., Kalra, Divya, Karlson, Elizabeth W., Keating, Brendan J., Kelly, Melissa A., Kenny, Eimear E., Key, Dustin, Kiryluk, Krzysztof, Kitchner, Terrie, Klanderman, Barbara, Klee, Eric, Kochan, David C., Korchina, Viktoriya, Kottyan, Leah, Kudalkar, Emily, Rahm, Alanna Kulchak, Kullo, Iftikhar J., Lammers, Philip, Larson, Eric B., Lebo, Matthew S., Leduc, Magalie, Lee, Ming Ta (Michael), Lennon, Niall J., Leppig, Kathleen A., Leslie, Nancy D., Li, Rongling, Liang, Wayne H., Lin, Chiao-Feng, Linder, Jodell E., Lindor, Noralane M., Lingren, Todd, Linneman, James G., Liu, Cong, Liu, Wen, Liu, Xiuping, Lynch, John, Lyon, Hayley, Macbeth, Alyssa, Mahadeshwar, Harshad, Mahanta, Lisa, Malin, Bradley, Manolio, Teri, Marasa, Maddalena, Marsolo, Keith, McGowan, Michelle L., McNally, Elizabeth, Meldrim, Jim, Mentch, Frank, Rasouly, Hila Milo, Mosley, Jonathan, Mukherjee, Shubhabrata, Mullen, Thomas E., Muniz, Jesse, Murdock, David R., Murphy, Shawn, Myers, Melanie F., Namjou, Bahram, Ni, Yizhao, Onofrio, Robert C., Obeng, Aniwaa Owusu, Person, Thomas N., Peterson, Josh F., Petukhova, Lynn, Pisieczko, Cassandra J., Pratap, Siddharth, Prows, Cynthia A., Puckelwartz, Megan J., Raj, Ritika, Ralston, James D., Ramaprasan, Arvind, Ramirez, Andrea, Rasmussen, Luke, Rasmussen-Torvik, Laura, Raychaudhuri, Soumya, Rehm, Heidi L., Ritchie, Marylyn D., Rives, Catherine, Riza, Beenish, Roden, Dan M., Rosenthal, Elisabeth A., Santani, Avni, Dan, Schaid, Scherer, Steven, Scott, Stuart, Scrol, Aaron, Sengupta, Soumitra, Shang, Ning, Sharma, Himanshu, Sharp, Richard R., Singh, Rajbir, Sleiman, Patrick M.A., Slowik, Kara, Smith, Joshua C., Smith, Maureen E., Smoot, Duane T., Smoller, Jordan W., Sohn, Sunghwan, Stanaway, Ian B., Starren, Justin, Stroud, Mary, Su, Jessica, Taylor, Casey Overby, Tolwinski, Kasia, Van Driest, Sara L., Vargas, Sean M., Varugheese, Matthew, Veenstra, David, Venner, Eric, Verbitsky, Miguel, Vicente, Gina, Wagner, Michael, Walker, Kimberly, Walunas, Theresa, Wang, Liwen, Wang, Qiaoyan, Weiss, Scott T., Wells, Quinn S., White, Peter S., Wiley, Ken L., Jr, Williams, Janet L., Williams, Marc S., Wilson, Michael W., Witkowski, Leora, Woods, Laura Allison, Woolf, Betty, Wynn, Julia, Yang, Yaping, Zhang, Ge, Zhang, Lan, and Zouk, Hana

Published
2021
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8. ACMG SF v3.0 list for reporting of secondary findings in clinical exome and genome sequencing: a policy statement of the American College of Medical Genetics and Genomics (ACMG)

Author

Miller, David T., Lee, Kristy, Chung, Wendy K., Gordon, Adam S., Herman, Gail E., Klein, Teri E., Stewart, Douglas R., Amendola, Laura M., Adelman, Kathy, Bale, Sherri J., Gollob, Michael H., Harrison, Steven M., Hershberger, Ray E., McKelvey, Kent, Richards, C. Sue, Vlangos, Christopher N., Watson, Michael S., and Martin, Christa Lese

Published
2021
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9. Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2021 update: a policy statement of the American College of Medical Genetics and Genomics (ACMG)

Author

Miller, David T., Lee, Kristy, Gordon, Adam S., Amendola, Laura M., Adelman, Kathy, Bale, Sherri J., Chung, Wendy K., Gollob, Michael H., Harrison, Steven M., Herman, Gail E., Hershberger, Ray E., Klein, Teri E., McKelvey, Kent, Richards, C. Sue, Vlangos, Christopher N., Stewart, Douglas R., Watson, Michael S., and Martin, Christa Lese

Published
2021
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10. Correction to: ACMG SF v3.0 list for reporting of secondary findings in clinical exome and genome sequencing: a policy statement of the American College of Medical Genetics and Genomics (ACMG)

Author

Miller, David T., Lee, Kristy, Chung, Wendy K., Gordon, Adam S., Herman, Gail E., Klein, Teri E., Stewart, Douglas R., Amendola, Laura M., Adelman, Kathy, Bale, Sherri J., Gollob, Michael H., Harrison, Steven M., Hershberger, Ray E., McKelvey, Kent, Richards, C. Sue, Vlangos, Christopher N., Watson, Michael S., and Martin, Christa Lese

Published
2021
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11. Medical records-based chronic kidney disease phenotype for clinical care and “big data” observational and genetic studies

Author

Shang, Ning, Khan, Atlas, Polubriaginof, Fernanda, Zanoni, Francesca, Mehl, Karla, Fasel, David, Drawz, Paul E., Carrol, Robert J., Denny, Joshua C., Hathcock, Matthew A., Arruda-Olson, Adelaide M., Peissig, Peggy L., Dart, Richard A., Brilliant, Murray H., Larson, Eric B., Carrell, David S., Pendergrass, Sarah, Verma, Shefali Setia, Ritchie, Marylyn D., Benoit, Barbara, Gainer, Vivian S., Karlson, Elizabeth W., Gordon, Adam S., Jarvik, Gail P., Stanaway, Ian B., Crosslin, David R., Mohan, Sumit, Ionita-Laza, Iuliana, Tatonetti, Nicholas P., Gharavi, Ali G., Hripcsak, George, Weng, Chunhua, and Kiryluk, Krzysztof

Published
2021
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12. Association between triglycerides, known risk SNVs and conserved rare variation in SLC25A40 in a multi-ancestry cohort

Author

Rosenthal, Elisabeth A., Crosslin, David R., Gordon, Adam S., Carrell, David S., Stanaway, Ian B., Larson, Eric B., Grafton, Jane, Wei, Wei-Qi, Denny, Joshua C., Feng, Qi-Ping, Shah, Amy S., Sturm, Amy C., Ritchie, Marylyn D., Pacheco, Jennifer A., Hakonarson, Hakon, Rasmussen-Torvik, Laura J., Connolly, John J., Fan, Xiao, Safarova, Maya, Kullo, Iftikhar J., and Jarvik, Gail P.

Published
2021
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13. Association of Genetic Risk of Obesity with Postoperative Complications Using Mendelian Randomization

Author

Robinson, Jamie R., Carroll, Robert J., Bastarache, Lisa, Chen, Qingxia, Mou, Zongyang, Wei, Wei-Qi, Connolly, John J., Mentch, Frank, Sleiman, Patrick, Crane, Paul K., Hebbring, Scott J., Stanaway, Ian B., Crosslin, David R., Gordon, Adam S., Rosenthal, Elisabeth A., Carrell, David, Hayes, M. Geoffrey, Wei, Wei, Petukhova, Lynn, Namjou, Bahram, Zhang, Ge, Safarova, Maya S., Walton, Nephi A., Still, Christopher, Bottinger, Erwin P., Loos, Ruth J. F., Murphy, Shawn N., Jackson, Gretchen P., Kullo, Iftikhar J., Hakonarson, Hakon, Jarvik, Gail P., Larson, Eric B., Weng, Chunhua, Roden, Dan M., and Denny, Joshua C.

Published
2020
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14. Harmonizing Clinical Sequencing and Interpretation for the eMERGE III Network

Author

Zouk, Hana, Venner, Eric, Lennon, Niall J., Muzny, Donna M., Abrams, Debra, Adunyah, Samuel, Albertson-Junkans, Ladia, Ames, Darren C., Appelbaum, Paul, Aronson, Samuel, Aufox, Sharon, Babb, Lawrence J., Balasubramanian, Adithya, Bangash, Hana, Basford, Melissa, Bastarache, Lisa, Baxter, Samantha, Behr, Meckenzie, Benoit, Barbara, Bhoj, Elizabeth, Bielinski, Suzette J., Bland, Sarah T., Blout, Carrie, Borthwick, Kenneth, Bottinger, Erwin P., Bowser, Mark, Brand, Harrison, Brilliant, Murray, Brodeur, Wendy, Caraballo, Pedro, Carrell, David, Carroll, Andrew, Almoguera, Berta, Castillo, Lisa, Castro, Victor, Chandanavelli, Gauthami, Chiang, Theodore, Chisholm, Rex L., Christensen, Kurt D., Chung, Wendy, Chute, Christopher G., City, Brittany, Cobb, Beth L., Connolly, John J., Crane, Paul, Crew, Katherine, Crosslin, David, De Andrade, Mariza, De la Cruz, Jessica, Denson, Shawn, Denny, Josh, DeSmet, Tim, Dikilitas, Ozan, Friedrich, Christopher, Fullerton, Stephanie M., Funke, Birgit, Gabriel, Stacey, Gainer, Vivian, Gharavi, Ali, Glazer, Andrew M., Glessner, Joseph T., Goehringer, Jessica, Gordon, Adam S., Graham, Chet, Green, Robert C., Gundelach, Justin H., Dayal, Jyoti, Hain, Heather S., Hakonarson, Hakon, Harden, Maegan V., Harley, John, Harr, Margaret, Hartzler, Andrea, Hayes, M. Geoffrey, Hebbring, Scott, Henrikson, Nora, Hershey, Andrew, Hoell, Christin, Holm, Ingrid, Howell, Kayla M., Hripcsak, George, Hu, Jianhong, Jarvik, Gail P., Jayaseelan, Joy C., Jiang, Yunyun, Joo, Yoonjung Yoonie, Jose, Sheethal, Josyula, Navya Shilpa, Justice, Anne E., Kalla, Sara E., Kalra, Divya, Karlson, Elizabeth, Kelly, Melissa A., Keating, Brendan J., Kenny, Eimear E., Key, Dustin, Kiryluk, Krzysztof, Kitchner, Terrie, Klanderman, Barbara, Klee, Eric, Kochan, David C., Korchina, Viktoriya, Kottyan, Leah, Kovar, Christie, Kudalkar, Emily, Kullo, Iftikhar J., Lammers, Philip, Larson, Eric B., Lebo, Matthew S., Leduc, Magalie, Lee, Ming Ta (Michael), Leppig, Kathleen A., Leslie, Nancy D., Li, Rongling, Liang, Wayne H., Lin, Chiao-Feng, Linder, Jodell, Lindor, Noralane M., Lingren, Todd, Linneman, James G., Liu, Cong, Liu, Wen, Liu, Xiuping, Lynch, John, Lyon, Hayley, Macbeth, Alyssa, Mahadeshwar, Harshad, Mahanta, Lisa, Malin, Brad, Manolio, Teri, Marasa, Maddalena, Marsolo, Keith, Dinsmore, Michael J., Dodge, Sheila, Hynes, Elizabeth Duffy, Dunlea, Phil, Edwards, Todd L., Eng, Christine M., Fasel, David, Fedotov, Alex, Feng, Qiping, Fleharty, Mark, Foster, Andrea, Freimuth, Robert, McGowan, Michelle L., McNally, Elizabeth, Meldrim, Jim, Mentch, Frank, Mosley, Jonathan, Mukherjee, Shubhabrata, Mullen, Thomas E., Muniz, Jesse, Murdock, David R., Murphy, Shawn, Murugan, Mullai, Myers, Melanie F., Namjou, Bahram, Ni, Yizhao, Obeng, Aniwaa Owusu, Onofrio, Robert C., Taylor, Casey Overby, Person, Thomas N., Peterson, Josh F., Petukhova, Lynn, Pisieczko, Cassandra J., Pratap, Siddharth, Prows, Cynthia A., Puckelwartz, Megan J., Rahm, Alanna Kulchak, Raj, Ritika, Ralston, James D., Ramaprasan, Arvind, Ramirez, Andrea, Rasmussen, Luke, Rasmussen-Torvik, Laura, Rasouly, Hila Milo, Raychaudhuri, Soumya, Ritchie, Marylyn D., Rives, Catherine, Riza, Beenish, Roden, Dan, Rosenthal, Elisabeth A., Santani, Avni, Schaid, Dan, Scherer, Steven, Scott, Stuart, Scrol, Aaron, Sengupta, Soumitra, Shang, Ning, Sharma, Himanshu, Sharp, Richard R., Singh, Rajbir, Sleiman, Patrick M.A., Slowik, Kara, Smith, Joshua C., Smith, Maureen E., Smoller, Jordan W., Sohn, Sunghwan, Stanaway, Ian B., Starren, Justin, Stroud, Mary, Su, Jessica, Tolwinski, Kasia, Van Driest, Sara L., Vargas, Sean M., Varugheese, Matthew, Veenstra, David, Verbitsky, Miguel, Vicente, Gina, Wagner, Michael, Walker, Kimberly, Walunas, Theresa, Wang, Liwen, Wang, Qiaoyan, Wei, Wei-Qi, Weiss, Scott T., Wiesner, Georgia L., Wells, Quinn, Weng, Chunhua, White, Peter S., Wiley, Ken L., Jr., Williams, Janet L., Williams, Marc S., Wilson, Michael W., Witkowski, Leora, Woods, Laura Allison, Woolf, Betty, Wu, Tsung-Jung, Wynn, Julia, Yang, Yaping, Yi, Victoria, Zhang, Ge, Zhang, Lan, Rehm, Heidi L., and Gibbs, Richard A.

Published
2019
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16. Returning integrated genomic risk and clinical recommendations: The eMERGE study

Author

Linder, Jodell E., primary, Allworth, Aimee, additional, Bland, Sarah T., additional, Caraballo, Pedro J., additional, Chisholm, Rex L., additional, Clayton, Ellen Wright, additional, Crosslin, David R., additional, Dikilitas, Ozan, additional, DiVietro, Alanna, additional, Esplin, Edward D., additional, Forman, Sophie, additional, Freimuth, Robert R., additional, Gordon, Adam S., additional, Green, Richard, additional, Harden, Maegan V., additional, Holm, Ingrid A., additional, Jarvik, Gail P., additional, Karlson, Elizabeth W., additional, Labrecque, Sofia, additional, Lennon, Niall J., additional, Limdi, Nita A., additional, Mittendorf, Kathleen F., additional, Murphy, Shawn N., additional, Orlando, Lori, additional, Prows, Cynthia A., additional, Rasmussen, Luke V., additional, Rasmussen-Torvik, Laura, additional, Rowley, Robb, additional, Sawicki, Konrad Teodor, additional, Schmidlen, Tara, additional, Terek, Shannon, additional, Veenstra, David, additional, Velez Edwards, Digna R., additional, Absher, Devin, additional, Abul-Husn, Noura S., additional, Alsip, Jorge, additional, Bangash, Hana, additional, Beasley, Mark, additional, Below, Jennifer E., additional, Berner, Eta S., additional, Booth, James, additional, Chung, Wendy K., additional, Cimino, James J., additional, Connolly, John, additional, Davis, Patrick, additional, Devine, Beth, additional, Fullerton, Stephanie M., additional, Guiducci, Candace, additional, Habrat, Melissa L., additional, Hain, Heather, additional, Hakonarson, Hakon, additional, Harr, Margaret, additional, Haverfield, Eden, additional, Hernandez, Valentina, additional, Hoell, Christin, additional, Horike-Pyne, Martha, additional, Hripcsak, George, additional, Irvin, Marguerite R., additional, Kachulis, Christopher, additional, Karavite, Dean, additional, Kenny, Eimear E., additional, Khan, Atlas, additional, Kiryluk, Krzysztof, additional, Korf, Bruce, additional, Kottyan, Leah, additional, Kullo, Iftikhar J., additional, Larkin, Katie, additional, Liu, Cong, additional, Malolepsza, Edyta, additional, Manolio, Teri A., additional, May, Thomas, additional, McNally, Elizabeth M., additional, Mentch, Frank, additional, Miller, Alexandra, additional, Mooney, Sean D., additional, Murali, Priyanka, additional, Mutai, Brenda, additional, Muthu, Naveen, additional, Namjou, Bahram, additional, Perez, Emma F., additional, Puckelwartz, Megan J., additional, Rakhra-Burris, Tejinder, additional, Roden, Dan M., additional, Rosenthal, Elisabeth A., additional, Saadatagah, Seyedmohammad, additional, Sabatello, Maya, additional, Schaid, Dan J., additional, Schultz, Baergen, additional, Seabolt, Lynn, additional, Shaibi, Gabriel Q., additional, Sharp, Richard R., additional, Shirts, Brian, additional, Smith, Maureen E., additional, Smoller, Jordan W., additional, Sterling, Rene, additional, Suckiel, Sabrina A., additional, Thayer, Jeritt, additional, Tiwari, Hemant K., additional, Trinidad, Susan B., additional, Walunas, Theresa, additional, Wei, Wei-Qi, additional, Wells, Quinn S., additional, Weng, Chunhua, additional, Wiesner, Georgia L., additional, Wiley, Ken, additional, Peterson, Josh F., additional, Gordon, Adam, additional, Sobowale, Agboade, additional, Patel, Akshar, additional, Strong, Alanna, additional, Sherafati, Alborz, additional, Sherfati, Alborz, additional, Bick, Alex, additional, Chandel, Alka, additional, Rosenthal, Alyssa, additional, Khera, Amit, additional, Kontorovich, Amy, additional, Beck, Andrew, additional, Beck, Andy, additional, Espinoza, Angelica, additional, Lewis, Anna, additional, Prince, Anya, additional, Iverson, Ayuko, additional, Khales, Bahram Namjou, additional, Benoit, Barbara, additional, Hernan, Becca, additional, Kallman, Ben, additional, Kerman, Ben, additional, Shoemaker, Ben, additional, Satterfield, Benjamin, additional, Etheridge, Bethany, additional, Goff, Blake, additional, Freimuth, Bob, additional, Grundmeier, Bob, additional, Collier, Brenae, additional, Harnett, Brett, additional, Chang, Brian, additional, Piening, Brian, additional, Davis, Brittney, additional, Patterson, Candace, additional, Demetriou, Carmen, additional, Ta, Casey, additional, Hammack, Catherine, additional, Nelson, Catrina, additional, Gascoigne, Caytie, additional, Dorn, Chad, additional, Moretz, Chad, additional, Kachulis, Chris, additional, Hoell, Christie, additional, Cowles, Christine, additional, Lange, Christoph, additional, Prows, Cindy, additional, Brokamp, Cole, additional, Scherr, Courtney, additional, Gonzalez, Crystal, additional, Ramirez, Cynthia, additional, Shimbo, Daichi, additional, Roden, Dan, additional, Schaid, Daniel, additional, Kaufman, Dave, additional, Crosslin, David, additional, Kochan, David, additional, Singh, Davinder, additional, Abrams, Debbie, additional, Edwards, Digna Velez, additional, Morales, Eduardo, additional, Esplin, Edward, additional, Alipour, Ehsan, additional, Kenny, Eimear, additional, Rosenthal, Elisabeth, additional, Duvall, Eliza, additional, McNally, Elizabeth, additional, Bhoj, Elizabeth, additional, Cohn, Elizabeth, additional, Hibler, Elizabeth, additional, Karlson, Elizabeth, additional, Clayton, Ellen, additional, Chesnut, Emily, additional, DeFranco, Emily, additional, Gallagher, Emily, additional, Soper, Emily, additional, Perez, Emma, additional, Cash, Erin, additional, Berner, Eta, additional, Wang, Fei, additional, Wehbe, Firas, additional, Ricci, Francisco, additional, Shaibi, Gabriel, additional, Jarvik, Gail, additional, Hahn, George, additional, Wiesner, Georgia, additional, Belbin, Gillian, additional, Davogustto, Gio, additional, Nadkarni, Girish, additional, Qiu, Haijun, additional, Beasley, Hannah, additional, Liu, Hao, additional, Aungst, Heide, additional, Tiwari, Hemant, additional, Duckham, Hillary, additional, Thomas, Hope, additional, Kullo, Iftikhar, additional, Holm, Ingrid, additional, Allen, Isabelle, additional, Ionita-Laza, Iuliana, additional, Hellwege, Jacklyn, additional, Petrzelka, Jacob, additional, Odgis, Jacqueline, additional, Narula, Jahnavi, additional, Petrzelka, Jake, additional, Patel, Jalpa, additional, Cimino, James, additional, Meigs, James, additional, Snyder, James, additional, Olson, Janet, additional, Zahner, Janet, additional, Pennington, Jeff, additional, Pacheco, Jen, additional, Pacheco, Jennifer Allen, additional, Morse, Jennifer, additional, Corsmo, Jeremy, additional, Cimino, Jim, additional, Chen, Jingheng, additional, Fournier, Jocelyn, additional, Jackson, Jodell, additional, Glessner, Joe, additional, Pacyna, Joel, additional, Smith, Johanna, additional, Lynch, John, additional, Shelley, John, additional, Mosley, Jonathan, additional, Nestor, Jordan, additional, Smoller, Jordan, additional, Kannry, Joseph, additional, Sutton, Joseph, additional, Peterson, Josh, additional, Smith, Joshua, additional, Galasso, Julia, additional, Smith, Julia, additional, Wynn, Julia, additional, Gundelach, Justin, additional, Starren, Justin, additional, Choi, Karmel, additional, Mittendorf, Kate, additional, Anderson, Katherine, additional, Bonini, Katherine, additional, Leppig, Kathleen, additional, Muenzen, Kathleen, additional, Stuttgen, Kelsey, additional, Nguyen, Kenny, additional, Dufendach, Kevin, additional, Atkins, Kiley, additional, Sawicki, Konrad, additional, Norland, Kristjan, additional, Beskow, Laura, additional, Hsu, Li, additional, Tian, Lifeng, additional, Mahanta, Lisa, additional, Martin, Lisa, additional, Wang, Lisa, additional, Gomez, Lizbeth, additional, Thompson, Lorenzo, additional, Richter, Lucas, additional, Rasmussen, Luke, additional, Petukhova, Lynn, additional, O’Brien, Madison, additional, Harden, Maegan, additional, Fullerton, Malia, additional, Guindo, Marta, additional, Horike, Martha, additional, Abdalla, Marwah, additional, Hamed, Marwan, additional, Terry, Mary Beth, additional, Maradik, Mary, additional, Wyatt, Matt, additional, Davis, Matthew, additional, Lebo, Matthew, additional, Smith, Maureen, additional, Rosario, Maya del, additional, Behr, Meckenzie, additional, Roy-Puckelwartz, Meg, additional, Habrat, Mel, additional, Myers, Melanie, additional, Yetisgen, Meliha, additional, Iris, Merve, additional, DaSilva, Michael, additional, Preuss, Michael, additional, McGowan, Michelle, additional, Shi, Mingjian, additional, Perera, Minoli, additional, Thomas, Minta, additional, Elkind, Mitch, additional, Abbass, Mohammad, additional, Saadatagah, Mohammad, additional, Hess, Molly, additional, Maradik, Molly, additional, Vaitinadin, Nataraja “RJ”, additional, Vaitinadin, Nataraja, additional, Netherly, Neil, additional, Lennon, Niall, additional, Shang, Ning, additional, Limdi, Nita, additional, Forrest, Noah, additional, Romero, Noheli, additional, Robinson, Nora, additional, Abul-Husn, Noura, additional, Elsekaily, Omar, additional, Kovatch, Patricia, additional, Appelbaum, Paul, additional, Francaviglia, Paul, additional, O’Reilly, Paul, additional, Chandler, Paulette, additional, Caraballo, Pedro, additional, Tarczy-Hornoch, Peter, additional, Shum, Pierre, additional, Marathe, Priya, additional, Feng, Qiping, additional, Wells, Quinn, additional, Atchley, Rachel, additional, Narla, Radhika, additional, Barton, Rene, additional, Chisholm, Rex, additional, Sharp, Richard, additional, Peters, Riki, additional, Kukafka, Rita, additional, Freimuth, Robert, additional, Green, Robert, additional, Winter, Robert, additional, Mueller, Roger, additional, Loos, Ruth, additional, Irvin, Ryan, additional, Suckiel, Sabrina, additional, Hussain, Sajjad, additional, Sharba, Samer, additional, Aronson, Sandy, additional, Jones, Sarah, additional, Knerr, Sarah, additional, Nigbur, Scott, additional, Weiss, Scott, additional, Mooney, Sean, additional, Aufox, Sharon, additional, Nirenberg, Sharon, additional, Murphy, Shawn, additional, O’Byrne, Sheila, additional, Wang (Sam) Choi, Shing, additional, Aguilar, Sienna, additional, Bland, S.T., additional, Rodrigues, Stefanie, additional, Ledbetter, Stephanie, additional, Rutledge, Stephanie, additional, Booth, Stuart James, additional, Xian, Su, additional, Trinidad, Susan Brown, additional, Bakken, Suzanne, additional, Manolio, Teri, additional, Mersha, Tesfaye, additional, Chandereng, Thevaa, additional, Ge, Tian, additional, Edwards, Todd, additional, Kaszemacher, Tom, additional, Willis, Valerie, additional, Desai, Vemi, additional, Desai, Vimi, additional, Lorenzi, Virginia, additional, Gainer, Vivian, additional, Chung, Wendy, additional, Su, Wu-Chen, additional, Chang, Xiao, additional, Zhao, Yiqing, additional, Luo, Yuan, additional, and Shen, Yufeng, additional

Published
2023
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18. Quantifying the phenome‐wide disease burden of obesity using electronic health records and genomics

Author

Robinson, Jamie R., primary, Carroll, Robert J., additional, Bastarache, Lisa, additional, Chen, Qingxia, additional, Pirruccello, James, additional, Mou, Zongyang, additional, Wei, Wei‐Qi, additional, Connolly, John, additional, Mentch, Frank, additional, Crane, Paul K., additional, Hebbring, Scott J., additional, Crosslin, David R., additional, Gordon, Adam S., additional, Rosenthal, Elisabeth A., additional, Stanaway, Ian B., additional, Hayes, M. Geoffrey, additional, Wei, Wei, additional, Petukhova, Lynn, additional, Namjou‐Khales, Bahram, additional, Zhang, Ge, additional, Safarova, Mayya S., additional, Walton, Nephi A., additional, Still, Christopher, additional, Bottinger, Erwin P., additional, Loos, Ruth J. F., additional, Murphy, Shawn N., additional, Jackson, Gretchen P., additional, Abumrad, Naji, additional, Kullo, Iftikhar J., additional, Jarvik, Gail P., additional, Larson, Eric B., additional, Weng, Chunhua, additional, Roden, Dan, additional, Khera, Amit V., additional, and Denny, Joshua C., additional

Published
2022
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19. Probing the Virtual Proteome to Identify Novel Disease Biomarkers

Author

Mosley, Jonathan D., Benson, Mark D., Smith, J. Gustav, Melander, Olle, Ngo, Debby, Shaffer, Christian M., Ferguson, Jane F., Herzig, Matthew S., McCarty, Catherine A., Chute, Christopher G., Jarvik, Gail P., Gordon, Adam S., Palmer, Melody R., Crosslin, David R., Larson, Eric B., Carrell, David S., Kullo, Iftikhar J., Pacheco, Jennifer A., Peissig, Peggy L., Brilliant, Murray H., Kitchner, Terrie E., Linneman, James G., Namjou, Bahram, Williams, Marc S., Ritchie, Marylyn D., Borthwick, Kenneth M., Kiryluk, Krzysztof, Mentch, Frank D., Sleiman, Patrick M., Karlson, Elizabeth W., Verma, Shefali S., Zhu, Yineng, Vasan, Ramachandran S., Yang, Qiong, Denny, Josh C., Roden, Dan M., Gerszten, Robert E., and Wang, Thomas J.

Published
2018
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20. ACMG SF v3.1 list for reporting of secondary findings in clinical exome and genome sequencing: A policy statement of the American College of Medical Genetics and Genomics (ACMG)

Author

Miller, David T., primary, Lee, Kristy, additional, Abul-Husn, Noura S., additional, Amendola, Laura M., additional, Brothers, Kyle, additional, Chung, Wendy K., additional, Gollob, Michael H., additional, Gordon, Adam S., additional, Harrison, Steven M., additional, Hershberger, Ray E., additional, Klein, Teri E., additional, Richards, Carolyn Sue, additional, Stewart, Douglas R., additional, and Martin, Christa Lese, additional

Published
2022
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21. Practitioners’ Confidence and Desires for Education in Cardiovascular and Sudden Cardiac Death Genetics

Author

Lopez Santibanez Jacome, Laura, primary, Dellefave‐Castillo, Lisa M., additional, Wicklund, Catherine A., additional, Scherr, Courtney L., additional, Duquette, Debra, additional, Webster, Gregory, additional, Smith, Maureen E., additional, Kalke, Kerstin, additional, Gordon, Adam S., additional, De Berg, Kristen, additional, McNally, Elizabeth M., additional, and Rasmussen‐Torvik, Laura J., additional

Published
2022
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22. Response to McGurk et al

Author

Gollob, Michael H., primary, Hershberger, Ray E., additional, Gordon, Adam S., additional, Harrison, Steven M., additional, Lee, Kristy, additional, Martin, Christa Lese, additional, and Miller, David T., additional

Published
2022
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23. Anti-racist strategies for clinical and translational research: Design, implementation, and lessons learned from a new course.

Author

Heard-Garris, Nia J., Brown, Jen F., Ewulonu, Uchenna C., Goel, Mita S., Gordon, Adam S., Henley, Candace, Khan, Sadiya S., Smith, Shawn M., and McColley, Susanna A.

Abstract

Translational research should examine racism and bias and improve health equity. We designed and implemented a course for the Master of Science in Clinical Investigation program of the Northwestern University Clinical and Translational Sciences Institute. We describe curriculum development, content, outcomes, and revisions involving 36 students in 2 years of "Anti-Racist Strategies for Clinical and Translational Science." Ninety-six percent of students reported they would recommend the course. Many reported changes in research approaches based on course content. A course designed to teach anti-racist research design is feasible and has a positive short-term impact on learners. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset

Author

Gordon, Adam S., Tabor, Holly K., Johnson, Andrew D., Snively, Beverly M., Assimes, Themistocles L., Auer, Paul L., Ioannidis, John P.A., Peters, Ulrike, Robinson, Jennifer G., Sucheston, Lara E., Wang, Danxin, Sotoodehnia, Nona, Rotter, Jerome I., Psaty, Bruce M., Jackson, Rebecca D., Herrington, David M., OʼDonnell, Christopher J., Reiner, Alexander P., Rich, Stephen S., Rieder, Mark J., Bamshad, Michael J., and Nickerson, Deborah A.

Published
2014
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27. Pleiotropy of systemic lupus erythematosus risk alleles and cardiometabolic disorders: A phenome-wide association study and inverse-variance weighted meta-analysis

Author

Kawai, Vivian K, primary, Shi, Mingjian, additional, Liu, Ge, additional, Feng, QiPing, additional, Wei, WeiQi, additional, Chung, Cecilia P, additional, Walunas, Theresa L, additional, Gordon, Adam S, additional, Linneman, James G, additional, Hebbring, Scott J, additional, Harley, John B, additional, Cox, Nancy J, additional, Roden, Dan M, additional, Stein, C Michael, additional, and Mosley, Jonathan D, additional

Published
2021
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28. Penetrance of Breast Cancer Susceptibility Genes from the eMERGE III Network

Author

Fan, Xiao, primary, Wynn, Julia, additional, Shang, Ning, additional, Liu, Cong, additional, Fedotov, Alexander, additional, Hallquist, Miranda L G, additional, Buchanan, Adam H, additional, Williams, Marc S, additional, Smith, Maureen E, additional, Hoell, Christin, additional, Rasmussen-Torvik, Laura J, additional, Peterson, Josh F, additional, Wiesner, Georgia L, additional, Murad, Andrea M, additional, Jarvik, Gail P, additional, Gordon, Adam S, additional, Rosenthal, Elisabeth A, additional, Stanaway, Ian B, additional, Crosslin, David R, additional, Larson, Eric B, additional, Leppig, Kathleen A, additional, Henrikson, Nora B, additional, Williams, Janet L, additional, Li, Rongling, additional, Hebbring, Scott, additional, Weng, Chunhua, additional, Shen, Yufeng, additional, Crew, Katherine D, additional, and Chung, Wendy K, additional

Published
2021
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29. Practice Patterns After Return of Rare Variants Associated With Cardiomyopathy in the Electronic Medical Records and Genomics Network

Author

Khan, Sadiya S., primary, Hoell, Christin, additional, Castillo, Lisa M., additional, Connolly, John J., additional, Crosslin, David R., additional, Chung, Wendy K., additional, Gordon, Adam S., additional, Harr, Margaret, additional, Jarvik, Gail P., additional, Kullo, Iftikhar, additional, Larson, Eric B., additional, Leppig, Kathleen A., additional, Manolio, Teri, additional, Pacheco, Jennifer A., additional, Ralston, James D., additional, Puckelwartz, Megan J., additional, Smith, Maureen E., additional, Wells, Quinn, additional, McNally, Elizabeth M., additional, and Rasmussen-Torvik, Laura J., additional

Published
2021
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30. Penetrance of breast cancer genes from the eMERGE III Network

Author

Fan, Xiao, primary, Wynn, Julia, additional, Ning, Shang, additional, Liu, Cong, additional, Fedotov, Alexander, additional, Hallquist, Miranda LG, additional, Buchanan, Adam H, additional, Williams, Marc S, additional, Smith, Maureen E, additional, Hoell, Christin, additional, Rasmussen-Torvik, Laura J, additional, Peterson, Josh F, additional, Wiesner, Georgia L, additional, Murad, Andrea, additional, Jarvik, Gail P, additional, Gordon, Adam S, additional, Rosenthal, Elisabeth A, additional, Stanaway, Ian B, additional, Crosslin, David R, additional, Larson, Eric B, additional, Leppig, Kathy A, additional, Henrikson, Nora B, additional, Williams, Janet L, additional, Li, Rongling, additional, Hebbring, Scott, additional, Weng, Chunhua, additional, Shen, Yufeng, additional, Crew, Kathleen D, additional, and Chung, Wendy K, additional

Published
2021
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32. The eMERGE genotype set of 83,717 subjects imputed to ~40 million variants genome wide and association with the herpes zoster medical record phenotype

Author

Stanaway, Ian B., Hall, Taryn O., Rosenthal, Elisabeth A., Palmer, Melody, Naranbhai, Vivek, Knevel, Rachel, Namjou‐Khales, Bahram, Carroll, Robert J., Kiryluk, Krzysztof, Gordon, Adam S., Linder, Jodell, Howell, Kayla Marie, Mapes, Brandy M., Lin, Frederick T.J., Joo, Yoonjung Yoonie, Hayes, M. Geoffrey, Gharavi, Ali G., Pendergrass, Sarah A., Ritchie, Marylyn D., de Andrade, Mariza, Croteau‐Chonka, Damien C., Raychaudhuri, Soumya, Weiss, Scott T., Lebo, Matt, Amr, Sami S., Carrell, David, Larson, Eric B., Chute, Christopher G., Rasmussen‐Torvik, Laura Jarmila, Roy‐Puckelwartz, Megan J., Sleiman, Patrick, Hakonarson, Hakon, Li, Rongling, Karlson, Elizabeth W., Peterson, Josh F., Kullo, Iftikhar J., Chisholm, Rex, Denny, Joshua Charles, Jarvik, Gail P., and Crosslin, David R.

Subjects
Male, variants, Principal Component Analysis, Homozygote, Black People, herpes zoster, Polymorphism, Single Nucleotide, White People, Phenotype, Haplotypes, genotypes, electronic medical records, GWAS, Chromosomes, Human, Electronic Health Records, Humans, Female, Genetic Predisposition to Disease, Research Articles, Algorithms, Research Article, Genome-Wide Association Study
Abstract

The Electronic Medical Records and Genomics (eMERGE) network is a network of medical centers with electronic medical records linked to existing biorepository samples for genomic discovery and genomic medicine research. The network sought to unify the genetic results from 78 Illumina and Affymetrix genotype array batches from 12 contributing medical centers for joint association analysis of 83,717 human participants. In this report, we describe the imputation of eMERGE results and methods to create the unified imputed merged set of genome‐wide variant genotype data. We imputed the data using the Michigan Imputation Server, which provides a missing single‐nucleotide variant genotype imputation service using the minimac3 imputation algorithm with the Haplotype Reference Consortium genotype reference set. We describe the quality control and filtering steps used in the generation of this data set and suggest generalizable quality thresholds for imputation and phenotype association studies. To test the merged imputed genotype set, we replicated a previously reported chromosome 6 HLA‐B herpes zoster (shingles) association and discovered a novel zoster‐associated loci in an epigenetic binding site near the terminus of chromosome 3 (3p29).

Published
2018

33. Hemochromatosis risk genotype is not associated with colorectal cancer or age at its diagnosis

Author

Jarvik, Gail P., Wang, Xiaoliang, Fontanillas, Pierre, Kim, Esther, Chanprasert, Sirisak, Gordon, Adam S., Bastarache, Lisa, Kowdley, Kris, V, Harrison, Tabitha, Rosenthal, Elisabeth A., Stanaway, Ian B., Bezieau, Stephane, Weinstein, Stephanie J., Newcomb, Polly A., Casey, Graham, Platz, Elizabeth A., Visvanathan, Kala, Le Marchand, Loic, Ulrich, Cornelia M., Hardikar, Sheetal, Li, Christopher, I, van Duijnhoven, Franzel J. B., Gsur, Andrea, Campbell, Peter T., Moreno, Victor, Vodicka, Pavel, Brenner, Hermann, Chang-Claude, Jenny, Hoffmeister, Michael, Slattery, Martha L., Gunter, Marc J., Aglago, Elom K., Castellvi-Bel, Sergi, Kweon, Sun-Seog, Chan, Andrew T., Li, Li, Zheng, Wei, Bishop, D. Timothy, Giles, Graham G., Rennert, Gad, Offit, Kenneth, Keku, Temitope O., Woods, Michael O., Hampe, Jochen, Van Guelpen, Bethan, Gallinger, Steven J., de la Chapelle, Albert, Hampel, Heather, Berndt, Sonja, I, Tangen, Catherine M., Lindblom, Annika, Wolk, Alicja, Burnett-Hartman, Andrea, Wu, Anna H., White, Emily, Gruber, Stephen B., Jenkins, Mark A., Mountain, Joanna, Peters, Ulrike, Crosslin, David R., Jarvik, Gail P., Wang, Xiaoliang, Fontanillas, Pierre, Kim, Esther, Chanprasert, Sirisak, Gordon, Adam S., Bastarache, Lisa, Kowdley, Kris, V, Harrison, Tabitha, Rosenthal, Elisabeth A., Stanaway, Ian B., Bezieau, Stephane, Weinstein, Stephanie J., Newcomb, Polly A., Casey, Graham, Platz, Elizabeth A., Visvanathan, Kala, Le Marchand, Loic, Ulrich, Cornelia M., Hardikar, Sheetal, Li, Christopher, I, van Duijnhoven, Franzel J. B., Gsur, Andrea, Campbell, Peter T., Moreno, Victor, Vodicka, Pavel, Brenner, Hermann, Chang-Claude, Jenny, Hoffmeister, Michael, Slattery, Martha L., Gunter, Marc J., Aglago, Elom K., Castellvi-Bel, Sergi, Kweon, Sun-Seog, Chan, Andrew T., Li, Li, Zheng, Wei, Bishop, D. Timothy, Giles, Graham G., Rennert, Gad, Offit, Kenneth, Keku, Temitope O., Woods, Michael O., Hampe, Jochen, Van Guelpen, Bethan, Gallinger, Steven J., de la Chapelle, Albert, Hampel, Heather, Berndt, Sonja, I, Tangen, Catherine M., Lindblom, Annika, Wolk, Alicja, Burnett-Hartman, Andrea, Wu, Anna H., White, Emily, Gruber, Stephen B., Jenkins, Mark A., Mountain, Joanna, Peters, Ulrike, and Crosslin, David R.

Abstract

Homozygotes for the higher penetrance hemochromatosis risk allele, HFE c.845G>A (p.Cys282Tyr, or C282Y), have been reported to be at a 2- to 3-fold increased risk for colorectal cancer (CRC). These results have been reported for small sample size studies with no information about age at diagnosis for CRC. An association with age at diagnosis might alter CRC screening recommendations. We analyzed two large European ancestry datasets to assess the association of HFE genotype with CRC risk and age at CRC diagnosis. The first dataset included 59,733 CRC or advanced adenoma cases and 72,351 controls from a CRC epidemiological study consortium. The second dataset included 13,564 self-reported CRC cases and 2,880,218 controls from the personal genetics company, 23andMe. No association of the common hereditary hemochromatosis (HH) risk genotype and CRC was found in either dataset. The odds ratios (ORs) for the association of CRC and HFE C282Y homozygosity were 1.08 (95% confidence interval [CI], 0.91-1.29; p = 0.4) and 1.01 (95% CI, 0.78-1.31, p = 0.9) in the two cohorts, respectively. Age at CRC diagnosis also did not differ by HFE C282Y/C282Y genotype in either dataset. These results indicate no increased CRC risk in individuals with HH genotypes and suggest that persons with HH risk genotypes can follow population screening recommendations for CRC.

Published
2020
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36. Hemochromatosis risk genotype is not associated with colorectal cancer or age at its diagnosis

Author

Jarvik, Gail P., primary, Wang, Xiaoliang, additional, Fontanillas, Pierre, additional, Kim, Esther, additional, Chanprasert, Sirisak, additional, Gordon, Adam S., additional, Bastarache, Lisa, additional, Kowdley, Kris V., additional, Harrison, Tabitha, additional, Rosenthal, Elisabeth A., additional, Stanaway, Ian B., additional, Bézieau, Stéphane, additional, Weinstein, Stephanie J., additional, Newcomb, Polly A., additional, Casey, Graham, additional, Platz, Elizabeth A., additional, Visvanathan, Kala, additional, Le Marchand, Loic, additional, Ulrich, Cornelia M., additional, Hardikar, Sheetal, additional, Li, Christopher I., additional, van Duijnhoven, Franzel J.B., additional, Gsur, Andrea, additional, Campbell, Peter T., additional, Moreno, Victor, additional, Vodička, Pavel, additional, Brenner, Hermann, additional, Chang-Claude, Jenny, additional, Hoffmeister, Michael, additional, Slattery, Martha L., additional, Gunter, Marc J., additional, Aglago, Elom K., additional, Castellví-Bel, Sergi, additional, Kweon, Sun-Seog, additional, Chan, Andrew T., additional, Li, Li, additional, Zheng, Wei, additional, Bishop, D. Timothy, additional, Giles, Graham G., additional, Rennert, Gad, additional, Offit, Kenneth, additional, Keku, Temitope O., additional, Woods, Michael O., additional, Hampe, Jochen, additional, Van Guelpen, Bethan, additional, Gallinger, Steven J., additional, de la Chapelle, Albert, additional, Hampel, Heather, additional, Berndt, Sonja I., additional, Tangen, Catherine M., additional, Lindblom, Annika, additional, Wolk, Alicja, additional, Burnett-Hartman, Andrea, additional, Wu, Anna H., additional, White, Emily, additional, Gruber, Stephen B., additional, Jenkins, Mark A., additional, Mountain, Joanna, additional, Peters, Ulrike, additional, and Crosslin, David R., additional

Published
2020
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37. Frequency of genomic secondary findings among 21,915 eMERGE network participants

Author

Gordon, Adam S., primary, Zouk, Hana, additional, Venner, Eric, additional, Eng, Christine M., additional, Funke, Birgit H., additional, Amendola, Laura M., additional, Carrell, David S., additional, Chisholm, Rex L., additional, Chung, Wendy K., additional, Denny, Joshua C., additional, Fedotov, Alexander, additional, Hakonarson, Hakon, additional, Kullo, Iftikhar J., additional, Larson, Eric B., additional, Leduc, Magalie S., additional, Leppig, Kathleen A., additional, Lennon, Niall J., additional, Linder, Jodell E., additional, Muzny, Donna M., additional, Prows, Cynthia A., additional, Rasmussen-Torvik, Laura J., additional, Rasouly, Hila Milo, additional, Roden, Dan M., additional, Rosenthal, Elisabeth A., additional, Smith, Maureen E., additional, Stanaway, Ian B., additional, Van Driest, Sara L., additional, Walker, Kimberly, additional, Wiesner, Georgia L., additional, Williams, Marc S., additional, Witkowski, Leora, additional, Crosslin, David R., additional, Gibbs, Richard A., additional, Rehm, Heidi L., additional, and Jarvik, Gail P., additional

Published
2020
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38. Arrhythmia Variant Associations and Reclassifications in the eMERGE-III Sequencing Study

Author

Glazer, Andrew M., Davogustto, Giovanni, Shaffer, Christian M., Vanoye, Carlos G., Desai, Reshma R., Farber-Eger, Eric H., Dikilitas, Ozan, Shang, Ning, Pacheco, Jennifer A., Yang, Tao, Muhammad, Ayesha, Mosley, Jonathan D., Van Driest, Sara L., Wells, Quinn S., Shaffer, Lauren Lee, Kalash, Olivia R., Wada, Yuko, Bland, Sarah, Yoneda, Zachary T., Mitchell, Devyn W., Kroncke, Brett M., Kullo, Iftikhar J., Jarvik, Gail P., Gordon, Adam S., Larson, Eric B., Manolio, Teri A., Mirshahi, Tooraj, Luo, Jonathan Z., Schaid, Daniel, Namjou, Bahram, Alsaied, Tarek, Singh, Rajbir, Singhal, Ashutosh, Liu, Cong, Weng, Chunhua, Hripcsak, George, Ralston, James D., McNally, Elizabeth M., Chung, Wendy K., Carrell, David S., Leppig, Kathleen A., Hakonarson, Hakon, Sleiman, Patrick, Sohn, Sunghwan, Glessner, Joseph, Denny, Joshua, Wei, Wei-Qi, George, Alfred L., Shoemaker, M. Benjamin, and Roden, Dan M.

Published
2022
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39. Association of Genetic Risk of Obesity with Postoperative Complications Using Mendelian Randomization

Author

Robinson, Jamie R., primary, Carroll, Robert J., additional, Bastarache, Lisa, additional, Chen, Qingxia, additional, Mou, Zongyang, additional, Wei, Wei-Qi, additional, Connolly, John J., additional, Mentch, Frank, additional, Sleiman, Patrick, additional, Crane, Paul K., additional, Hebbring, Scott J., additional, Stanaway, Ian B., additional, Crosslin, David R., additional, Gordon, Adam S., additional, Rosenthal, Elisabeth A., additional, Carrell, David, additional, Hayes, M. Geoffrey, additional, Wei, Wei, additional, Petukhova, Lynn, additional, Namjou, Bahram, additional, Zhang, Ge, additional, Safarova, Maya S., additional, Walton, Nephi A., additional, Still, Christopher, additional, Bottinger, Erwin P., additional, Loos, Ruth J. F., additional, Murphy, Shawn N., additional, Jackson, Gretchen P., additional, Kullo, Iftikhar J., additional, Hakonarson, Hakon, additional, Jarvik, Gail P., additional, Larson, Eric B., additional, Weng, Chunhua, additional, Roden, Dan M., additional, and Denny, Joshua C., additional

Published
2019
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40. Pleiotropy in the Genetic Predisposition to Rheumatoid Arthritis: A Phenome‐Wide Association Study and Inverse Variance–Weighted Meta‐Analysis.

Author

Kawai, Vivian K., Shi, Mingjian, Feng, Qiping, Chung, Cecilia P., Liu, Ge, Cox, Nancy J., Jarvik, Gail P., Lee, Ming T. M., Hebbring, Scott J., Harley, John B., Kaufman, Kenneth M., Namjou, Bahram, Larson, Eric, Gordon, Adam S., Roden, Dan M., Stein, C. Michael, and Mosley, Jonathan D.

Subjects
GENETICS of rheumatoid arthritis, MULTIPLE sclerosis risk factors, TYPE 1 diabetes, AUTOIMMUNE diseases, AUTOIMMUNE thyroiditis, C-reactive protein, CARDIOVASCULAR diseases risk factors, CONFIDENCE intervals, DEMYELINATION, DISEASE susceptibility, GENETICS, META-analysis, TYPE 2 diabetes, SYSTEMIC scleroderma, PHENOTYPES, DESCRIPTIVE statistics, ODDS ratio, DISEASE risk factors, DIABETES risk factors
Abstract

Objective: This study was undertaken to investigate the hypothesis that a genetic predisposition toward rheumatoid arthritis (RA) increases the risk of 10 cardiometabolic and autoimmune disorders previously associated with RA in epidemiologic studies, and to define new genetic pleiotropy present in RA. Methods: Two approaches were used to test our hypothesis. First, we constructed a weighted genetic risk score (wGRS) and then examined its association with 10 prespecified disorders. Additionally, a phenome‐wide association study (PheWAS) was carried out to identify potential new associations. Second, inverse variance–weighted regression (IVWR) meta‐analysis was used to characterize the association between genetic susceptibility to RA and the prespecified disorders, with the results expressed as odds ratios (ORs) and 95% confidence intervals (95% CIs). Results: The wGRS for RA was significantly associated with type 1 diabetes mellitus (DM) (OR 1.10 [95% CI 1.04–1.16]; P = 9.82 × 10−4) and multiple sclerosis (OR 0.82 [95% CI 0.77–0.88]; P = 1.73 × 10−8), but not with other cardiometabolic phenotypes. In the PheWAS, wGRS was also associated with an increased risk of several autoimmune phenotypes including RA, thyroiditis, and systemic sclerosis, and with a decreased risk of demyelinating disorders. In the IVWR meta‐analyses, RA was significantly associated with an increased risk of type 1 DM (P = 1.15 × 10−14), with evidence of horizontal pleiotropy (Mendelian Randomization–Egger intercept estimate P = 0.001) likely driven by rs2476601, a PTPN22 variant. The association between type 1 DM and RA remained significant (P = 9.53 × 10−9) after excluding rs2476601, with no evidence of horizontal pleiotropy (intercept estimate P = 0.939). RA was also significantly associated with type 2 DM and C‐reactive protein levels. These associations were driven by variation in the major histocompatibility complex region. Conclusion: This study presents evidence of pleiotropy between the genetic predisposition to RA and associated phenotypes found in other autoimmune and cardiometabolic disorders, including type 1 DM. [ABSTRACT FROM AUTHOR]

Published
2020
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41. A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers

Author

Mosley, Jonathan D., primary, Feng, QiPing, additional, Wells, Quinn S., additional, Van Driest, Sara L., additional, Shaffer, Christian M., additional, Edwards, Todd L., additional, Bastarache, Lisa, additional, Wei, Wei-Qi, additional, Davis, Lea K., additional, McCarty, Catherine A., additional, Thompson, Will, additional, Chute, Christopher G., additional, Jarvik, Gail P., additional, Gordon, Adam S., additional, Palmer, Melody R., additional, Crosslin, David R., additional, Larson, Eric B., additional, Carrell, David S., additional, Kullo, Iftikhar J., additional, Pacheco, Jennifer A., additional, Peissig, Peggy L., additional, Brilliant, Murray H., additional, Linneman, James G., additional, Namjou, Bahram, additional, Williams, Marc S., additional, Ritchie, Marylyn D., additional, Borthwick, Kenneth M., additional, Verma, Shefali S., additional, Karnes, Jason H., additional, Weiss, Scott T., additional, Wang, Thomas J., additional, Stein, C. Michael, additional, Denny, Josh C., additional, and Roden, Dan M., additional

Published
2018
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42. Concordance between Research Sequencing and Clinical Pharmacogenetic Genotyping in the eMERGE-PGx Study

Author

Rasmussen-Torvik, Laura J., primary, Almoguera, Berta, additional, Doheny, Kimberly F., additional, Freimuth, Robert R., additional, Gordon, Adam S., additional, Hakonarson, Hakon, additional, Hawkins, Jared B., additional, Husami, Ammar, additional, Ivacic, Lynn C., additional, Kullo, Iftikhar J., additional, Linderman, Michael D., additional, Manolio, Teri A., additional, Obeng, Aniwaa Owusu, additional, Pellegrino, Renata, additional, Prows, Cynthia A., additional, Ritchie, Marylyn D., additional, Smith, Maureen E., additional, Stallings, Sarah C., additional, Wolf, Wendy A., additional, Zhang, Kejian, additional, and Scott, Stuart A., additional

Published
2017
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43. Building a family network from genetic testing

Author

Leppig, Kathleen A., primary, Thiese, Heidi A., additional, Carrel, David, additional, Crosslin, David R., additional, Dorschner, Michael O., additional, Gordon, Adam S., additional, Hartzler, Andrea, additional, Ralston, James, additional, Scrol, Aaron, additional, Larson, Eric B., additional, and Jarvik, Gail P., additional

Published
2016
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44. The eMERGE genotype set of 83,717 subjects imputed to ~40 million variants genome wide and association with the herpes zoster medical record phenotype.

Author

Stanaway, Ian B., Hall, Taryn O., Rosenthal, Elisabeth A., Palmer, Melody, Naranbhai, Vivek, Knevel, Rachel, Namjou‐Khales, Bahram, Carroll, Robert J., Kiryluk, Krzysztof, Gordon, Adam S., Linder, Jodell, Howell, Kayla Marie, Mapes, Brandy M., Lin, Frederick T.J., Joo, Yoonjung Yoonie, Hayes, M. Geoffrey, Gharavi, Ali G., Pendergrass, Sarah A., Ritchie, Marylyn D., and Andrade, Mariza

Published
2019
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45. Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine

Author

Green, Robert C., primary, Goddard, Katrina A.B., additional, Jarvik, Gail P., additional, Amendola, Laura M., additional, Appelbaum, Paul S., additional, Berg, Jonathan S., additional, Bernhardt, Barbara A., additional, Biesecker, Leslie G., additional, Biswas, Sawona, additional, Blout, Carrie L., additional, Bowling, Kevin M., additional, Brothers, Kyle B., additional, Burke, Wylie, additional, Caga-anan, Charlisse F., additional, Chinnaiyan, Arul M., additional, Chung, Wendy K., additional, Clayton, Ellen W., additional, Cooper, Gregory M., additional, East, Kelly, additional, Evans, James P., additional, Fullerton, Stephanie M., additional, Garraway, Levi A., additional, Garrett, Jeremy R., additional, Gray, Stacy W., additional, Henderson, Gail E., additional, Hindorff, Lucia A., additional, Holm, Ingrid A., additional, Lewis, Michelle Huckaby, additional, Hutter, Carolyn M., additional, Janne, Pasi A., additional, Joffe, Steven, additional, Kaufman, David, additional, Knoppers, Bartha M., additional, Koenig, Barbara A., additional, Krantz, Ian D., additional, Manolio, Teri A., additional, McCullough, Laurence, additional, McEwen, Jean, additional, McGuire, Amy, additional, Muzny, Donna, additional, Myers, Richard M., additional, Nickerson, Deborah A., additional, Ou, Jeffrey, additional, Parsons, Donald W., additional, Petersen, Gloria M., additional, Plon, Sharon E., additional, Rehm, Heidi L., additional, Roberts, J. Scott, additional, Robinson, Dan, additional, Salama, Joseph S., additional, Scollon, Sarah, additional, Sharp, Richard R., additional, Shirts, Brian, additional, Spinner, Nancy B., additional, Tabor, Holly K., additional, Tarczy-Hornoch, Peter, additional, Veenstra, David L., additional, Wagle, Nikhil, additional, Weck, Karen, additional, Wilfond, Benjamin S., additional, Wilhelmsen, Kirk, additional, Wolf, Susan M., additional, Wynn, Julia, additional, Yu, Joon-Ho, additional, Amaral, Michelle, additional, Amendola, Laura, additional, Aronson, Samuel J., additional, Arora, Shubhangi, additional, Azzariti, Danielle R., additional, Barsh, Greg S., additional, Bebin, E.M., additional, Biesecker, Barbara B., additional, Brown, Brian L., additional, Burt, Amber A., additional, Byers, Peter H., additional, Calikoglu, Muge G., additional, Carlson, Sara J., additional, Chahin, Nizar, additional, Christensen, Kurt D., additional, Chung, Wendy, additional, Cirino, Allison L., additional, Clayton, Ellen, additional, Conlin, Laura K., additional, Cooper, Greg M., additional, Crosslin, David R., additional, Davis, James V., additional, Davis, Kelly, additional, Deardorff, Matthew A., additional, Devkota, Batsal, additional, De Vries, Raymond, additional, Diamond, Pamela, additional, Dorschner, Michael O., additional, Dugan, Noreen P., additional, Dukhovny, Dmitry, additional, Dulik, Matthew C., additional, East, Kelly M., additional, Rivera-Munoz, Edgar A., additional, Evans, Barbara, additional, Everett, Jessica, additional, Exe, Nicole, additional, Fan, Zheng, additional, Feuerman, Lindsay Z., additional, Filipski, Kelly, additional, Finnila, Candice R., additional, Fishler, Kristen, additional, Ghrundmeier, Bob, additional, Giles, Karen, additional, Gilmore, Marian J., additional, Girnary, Zahra S., additional, Goddard, Katrina, additional, Gonsalves, Steven, additional, Gordon, Adam S., additional, Gornick, Michele C., additional, Grady, William M., additional, Gray, David E., additional, Green, Robert, additional, Greenwood, Robert S., additional, Gutierrez, Amanda M., additional, Han, Paul, additional, Hart, Ragan, additional, Heagerty, Patrick, additional, Hensman, Naomi, additional, Hiatt, Susan M., additional, Himes, Patricia, additional, Hisama, Fuki M., additional, Ho, Carolyn Y., additional, Hoffman-Andrews, Lily B., additional, Hong, Celine, additional, Horike-Pyne, Martha J., additional, Hull, Sara, additional, Jamal, Seema, additional, Jensen, Brian C., additional, Joffe, Steve, additional, Johnston, Jennifer, additional, Karavite, Dean, additional, Kauffman, Tia L., additional, Kaufman, Dave, additional, Kelley, Whitley, additional, Kim, Jerry H., additional, Kirby, Christine, additional, Klein, William, additional, Knoppers, Bartha, additional, Kong, Sek Won, additional, Krantz, Ian, additional, Krier, Joel B., additional, Lamb, Neil E., additional, Lambert, Michele P., additional, Le, Lan Q., additional, Lebo, Matthew S., additional, Lee, Alexander, additional, Lee, Kaitlyn B., additional, Lennon, Niall, additional, Leo, Michael C., additional, Leppig, Kathleen A., additional, Lewis, Katie, additional, Lewis, Michelle, additional, Lindeman, Neal I., additional, Lockhart, Nicole, additional, Lonigro, Bob, additional, Lose, Edward J., additional, Lupo, Philip J., additional, Rodriguez, Laura Lyman, additional, Lynch, Frances, additional, Machini, Kalotina, additional, MacRae, Calum, additional, Marchuk, Daniel S., additional, Martinez, Josue N., additional, Masino, Aaron, additional, McLaughlin, Heather M., additional, McMullen, Carmit, additional, Mieczkowski, Piotr A., additional, Miller, Jeff, additional, Miller, Victoria A., additional, Mody, Rajen, additional, Mooney, Sean D., additional, Moore, Elizabeth G., additional, Morris, Elissa, additional, Murray, Michael, additional, Ng, David, additional, Oliver, Nelly M., additional, Parsons, Will, additional, Patrick, Donald L., additional, Pennington, Jeffrey, additional, Perry, Denise L., additional, Petersen, Gloria, additional, Plon, Sharon, additional, Porter, Katie, additional, Powell, Bradford C., additional, Punj, Sumit, additional, Breitkopf, Carmen Radecki, additional, Raesz-Martinez, Robin A., additional, Raskind, Wendy H., additional, Reigar, Dean A., additional, Reiss, Jacob A., additional, Rich, Carla A., additional, Richards, Carolyn Sue, additional, Rini, Christine, additional, Roberts, Scott, additional, Robertson, Peggy D., additional, Robinson, Jill O., additional, Robinson, Marguerite E., additional, Roche, Myra I., additional, Romasko, Edward J., additional, Rosenthal, Elisabeth A., additional, Salama, Joseph, additional, Scarano, Maria I., additional, Schneider, Jennifer, additional, Seidman, Christine E., additional, Seifert, Bryce A., additional, Shirts, Brian H., additional, Sholl, Lynette M., additional, Siddiqui, Javed, additional, Silverman, Elian, additional, Simmons, Shirley, additional, Simons, Janae V., additional, Skinner, Debra, additional, Stoffel, Elena, additional, Strande, Natasha T., additional, Sunyaev, Shamil, additional, Sybert, Virginia P., additional, Taber, Jennifer, additional, Taylor, Deanne M., additional, Tilley, Christian R., additional, Tomlinson, Ashley, additional, Trinidad, Susan, additional, Tsai, Ellen, additional, Ubel, Peter, additional, Van Allen, Eliezer M., additional, Vassy, Jason L., additional, Vats, Pankaj, additional, Vetter, Victoria L., additional, Vries, Raymond D., additional, Walser, Sarah A., additional, Walsh, Rebecca C., additional, Werner-Lin, Allison, additional, Whittle, Jana, additional, Wilfond, Ben, additional, Wilhelmsen, Kirk C., additional, Yang, Yaping, additional, Young, Carol, additional, and Zikmund-Fisher, Brian J., additional

Published
2016
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46. PGRNseq

Author

Gordon, Adam S., primary, Fulton, Robert S., additional, Qin, Xiang, additional, Mardis, Elaine R., additional, Nickerson, Deborah A., additional, and Scherer, Steve, additional

Published
2016
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47. Prospective participant selection and ranking to maximize actionable pharmacogenetic variants and discovery in the eMERGE Network

Author

Crosslin, David R., primary, Robertson, Peggy D., additional, Carrell, David S., additional, Gordon, Adam S., additional, Hanna, David S., additional, Burt, Amber, additional, Fullerton, Stephanie M., additional, Scrol, Aaron, additional, Ralston, James, additional, Leppig, Kathleen, additional, Hartzler, Andrea, additional, Baldwin, Eric, additional, Andrade, Mariza de, additional, Kullo, Iftikhar J., additional, Tromp, Gerard, additional, Doheny, Kimberly F., additional, Ritchie, Marylyn D., additional, Crane, Paul K., additional, Nickerson, Deborah A., additional, Larson, Eric B., additional, and Jarvik, Gail P., additional

Published
2015
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48. Building a family network from genetic testing.

Author

Leppig, Kathleen A., Thiese, Heidi A., Carrel, David, Crosslin, David R., Dorschner, Michael O., Gordon, Adam S., Hartzler, Andrea, Ralston, James, Scrol, Aaron, Larson, Eric B., and Jarvik, Gail P.

Subjects
GENETIC testing, GENETIC counseling, FAMILY health, PHARMACOGENOMICS, PHENOTYPES
Abstract

Background Genetic testing has multigenerational and familial repercussions. However, the 'trickle-down effect' of providing genetic counseling and testing to family members at risk after an initial identification of a pathogenic variant in a medically actionable gene has been poorly understood. Methods Three probands were identified during the pharmacogenetics research phase of eMERGEII (electronic MEdical Record and Genomics, phase II) to have variants in genes associated with autosomal dominant adult-onset disorders determined to be actionable by the American College of Medical Genetics ( ACMG). Two of the three probands had variants that were classified as pathogenic and the third proband had a variant ultimately classified of uncertain significance, but of concern due to the proband's own phenotype. All probands had additional family members at risk for inheriting the variant. Two of the three probands had family members who received their medical care from the same health care system, Group Health Cooperative ( GHC). It was recommended that the proband contact their family members at risk to be referred to genetic counseling for consideration of genetic testing. Results The two probands with pathogenic variants contacted some of their family members at risk. Individuals contacted included children and adult grandchildren, particularly if they received their medical care at GHC. To the best of our knowledge, siblings and more distant relatives at risk were not informed by the proband of their genetic risk. Conclusions Establishing a family network is essential to disseminate knowledge of genetic risk. These three initial cases describe our experience of contacting eMERGE participants with identified variants, providing the probands with appropriate genetic counseling and care coordination, and recommendations for contacting family members at risk. Greater challenges were observed for coordinating genetics care for family members and extending the family network to include other relatives at risk. [ABSTRACT FROM AUTHOR]

Published
2017
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49. Pathogenic Variants for Mendelian and Complex Traits in Exomes of 6,517 European and African Americans: Implications for the Return of Incidental Results

Author

Tabor, Holly K., primary, Auer, Paul L., additional, Jamal, Seema M., additional, Chong, Jessica X., additional, Yu, Joon-Ho, additional, Gordon, Adam S., additional, Graubert, Timothy A., additional, O’Donnell, Christopher J., additional, Rich, Stephen S., additional, Nickerson, Deborah A., additional, and Bamshad, Michael J., additional

Published
2014
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50. Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project

Author

Kim, Daniel Seung, primary, Crosslin, David R., additional, Auer, Paul L., additional, Suzuki, Stephanie M., additional, Marsillach, Judit, additional, Burt, Amber A., additional, Gordon, Adam S., additional, Meschia, James F., additional, Nalls, Mike A., additional, Worrall, Bradford B., additional, Longstreth, W.T., additional, Gottesman, Rebecca F., additional, Furlong, Clement E., additional, Peters, Ulrike, additional, Rich, Stephen S., additional, Nickerson, Deborah A., additional, and Jarvik, Gail P., additional

Published
2014
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