Search

Your search keyword '"Gopalakrishna, Gowri"' showing total 49 results
Start Over Author "Gopalakrishna, Gowri"
49 results on '"Gopalakrishna, Gowri"'

5. Scoping review and evidence mapping of interventions aimed at improving reproducible and replicable science: Protocol

Author

Dudda, Leonie A., primary, Kozula, Magdalena, additional, Ross-Hellauer, Tony, additional, Kormann, Eva, additional, Spijker, René, additional, DeVito, Nicholas, additional, Gopalakrishna, Gowri, additional, Van den Eynden, Veerle, additional, Onghena, Patrick, additional, Naudet, Florian, additional, Banzi, Rita, additional, Fratelli, Maddalena, additional, Varga, Monika, additional, Gelsleichter, Yuri Andrei, additional, Stegeman, Inge, additional, and Leeflang, Mariska M., additional

Published
2023
Full Text
View/download PDF

8. Protocol: Interventions

Author

Van Den Eynden, Veerle, Kertész, István, Baranyai, László, DeVito, Nicholas J, Colombo, Cinzia, Folly, Brenda Bley, Banzi, Rita, Stegeman, Inge, Florian, NAUDET, Staš, Jan, Varga, Monika, Leeflang, Mariska, Dudda, Leonie, Gopalakrishna, Gowri, Onghena, Patrick, Fratelli, Maddalena, and Kozula, Magdalena

Published
2023
Full Text
View/download PDF

9. Protocol: Outcome set

Author

Dudda, Leonie, Banzi, Rita, Leeflang, Mariska, Fratelli, Maddalena, Staš, Jan, Baranyai, László, DeVito, Nicholas J, Onghena, Patrick, Folly, Brenda Bley, Gopalakrishna, Gowri, Kertész, István, Varga, Monika, Colombo, Cinzia, Van Den Eynden, Veerle, Kozula, Magdalena, Stegeman, Inge, and Florian, NAUDET

Published
2023
Full Text
View/download PDF

10. HE META

Author

Macleod, Malcolm, Sena, Emily, Gopalakrishna, Gowri, Ross-Hellauer, Tony, and Hair, Kaitlyn

Published
2022
Full Text
View/download PDF

11. NSRI Data Analysis

Author

Sara, Gopalakrishna, Gowri, Wicherts, Jelte, Bouter, Lex, Van den Akker, Olmo, Riet, Gerben, and Vink, Gerko

Published
2022
Full Text
View/download PDF

12. National Survey on Research Integrity

Author

Gopalakrishna, Gowri, Wicherts, Jelte, Sara, Bouter, Lex, Van den Akker, Olmo, Hastings, Rosemary, and Open Science Framework

Abstract

www.nsri2020.nl

Published
2022

18. Fostering Research Integrity through the promotion of fairness, equity and diversity in research collaborations and contexts: Towards a Cape Town Statement (pre-conference discussion paper)

Author

Horn, Lyn, primary, Alba, Sandra, additional, Blom, Fenneke, additional, Faure, Marlyn, additional, Flack-Davison, Eleni, additional, Gopalakrishna, Gowri, additional, IJsselmuiden, Carel, additional, Labib, Krishma, additional, Lavery, James V, additional, Masekela, Refiloe, additional, Schroeder, Doris, additional, Simon, Natalie, additional, Van Zyl, Christa, additional, Vasconcelos, Sonia, additional, Visagie, Retha, additional, and Kombe, Francis, additional

Published
2022
Full Text
View/download PDF

19. Prevalence of questionable research practices, research misconduct and their potential explanatory factors:A survey among academic researchers in the Netherlands

Author

Gopalakrishna, Gowri, ter Riet, Gerben, Vink, Gerko, Stoop, Ineke, Wicherts, Jelte M., Bouter, Lex M., Leerstoel van Buuren, Methodology and statistics for the behavioural and social sciences, Cardiology, ACS - Diabetes & metabolism, APH - Aging & Later Life, APH - Personalized Medicine, Leerstoel van Buuren, Methodology and statistics for the behavioural and social sciences, Department of Methodology and Statistics, Epidemiology and Data Science, APH - Methodology, ACS - Atherosclerosis & ischemic syndromes, and Research integrity

Subjects
Male, bepress|Physical Sciences and Mathematics, Biomedical Research, Science, Scientific Misconduct, Ethics, Research, Biomedical Research/ethics, Surveys and Questionnaires, Prevalence, Humans, Scientific Misconduct/ethics, General, Research Design/standards, Ethics, MetaArXiv|Social and Behavioral Sciences, Multidisciplinary, Research, bepress|Medicine and Health Sciences, MetaArXiv|Medicine and Health Sciences, Research Personnel, MetaArXiv|Physical Sciences and Mathematics, Cross-Sectional Studies, Research Design, Research Personnel/ethics, bepress|Social and Behavioral Sciences, Medicine, Female
Abstract

BackgroundPrevalence of research misconduct, questionable research practices (QRPs) and their associations with a range of explanatory factors has not been studied sufficiently among academic researchers.Methods The National Survey on Research Integrity was aimed at all disciplinary fields and academic ranks in the Netherlands. The survey enquired about engagement in fabrication, falsification and 11 QRPs over the previous three years, and 12 explanatory factor scales. We ensured strict identity protection and used a randomized response method for questions on research misconduct. Results6,813 respondents completed the survey. Prevalence of fabrication was 4.3% (95% CI: 2.9, 5.7) and falsification 4.2% (95% CI: 2.8, 5.6). Prevalence of QRPs ranged from 0.6% (95% CI: 0.5, 0.9) to 17.5% (95 % CI: 16.4, 18.7) with 51.3% (95% CI: 50.1, 52.5) of respondents engaging frequently in ≥ 1 QRP. Being a PhD candidate or junior researcher increased the odds of frequently engaging in ≥ 1 QRP, as did being male. Scientific norm subscription (odds ratio (OR) 0.79; 95% CI: 0.63, 1.00) and perceived likelihood of detection by reviewers (OR 0.62, 95% CI: 0.44, 0.88) were associated with lower odds of research misconduct. Publication pressure was associated with higher odds of engaging frequently in ≥ 1 QRP (OR 1.22, 95% CI: 1.14, 1.30).ConclusionsWe found higher prevalence of misconduct than earlier surveys. Our results suggest that greater emphasis on scientific norm subscription, strengthening reviewers in their role as gatekeepers of research quality and curbing the “publish or perish” incentive system can promote research integrity.

Published
2022

20. Prevalence of questionable research practices, research misconduct and their potential explanatory factors: A survey among academic researchers in The Netherlands

Author

Gopalakrishna, Gowri, Ter Riet, Gerben, Vink, Gerko, Stoop, Ineke, Wicherts, Jelte M, Bouter, Lex M, Gopalakrishna, Gowri, Ter Riet, Gerben, Vink, Gerko, Stoop, Ineke, Wicherts, Jelte M, and Bouter, Lex M

Abstract

Prevalence of research misconduct, questionable research practices (QRPs) and their associations with a range of explanatory factors has not been studied sufficiently among academic researchers. The National Survey on Research Integrity targeted all disciplinary fields and academic ranks in the Netherlands. It included questions about engagement in fabrication, falsification and 11 QRPs over the previous three years, and 12 explanatory factor scales. We ensured strict identity protection and used the randomized response method for questions on research misconduct. 6,813 respondents completed the survey. Prevalence of fabrication was 4.3% (95% CI: 2.9, 5.7) and of falsification 4.2% (95% CI: 2.8, 5.6). Prevalence of QRPs ranged from 0.6% (95% CI: 0.5, 0.9) to 17.5% (95% CI: 16.4, 18.7) with 51.3% (95% CI: 50.1, 52.5) of respondents engaging frequently in at least one QRP. Being a PhD candidate or junior researcher increased the odds of frequently engaging in at least one QRP, as did being male. Scientific norm subscription (odds ratio (OR) 0.79; 95% CI: 0.63, 1.00) and perceived likelihood of detection by reviewers (OR 0.62, 95% CI: 0.44, 0.88) were associated with engaging in less research misconduct. Publication pressure was associated with more often engaging in one or more QRPs frequently (OR 1.22, 95% CI: 1.14, 1.30). We found higher prevalence of misconduct than earlier surveys. Our results suggest that greater emphasis on scientific norm subscription, strengthening reviewers in their role as gatekeepers of research quality and curbing the "publish or perish" incentive system promotes research integrity.

Published
2022
Full Text
View/download PDF

21. Prevalence of responsible research practices among academics in The Netherlands

Author

Leerstoel van Buuren, Methodology and statistics for the behavioural and social sciences, Gopalakrishna, Gowri, Wicherts, Jelte M., Vink, Gerko, Stoop, Ineke, van den Akker, Olmo R., ter Riet, Gerben, Bouter, Lex M., Leerstoel van Buuren, Methodology and statistics for the behavioural and social sciences, Gopalakrishna, Gowri, Wicherts, Jelte M., Vink, Gerko, Stoop, Ineke, van den Akker, Olmo R., ter Riet, Gerben, and Bouter, Lex M.

Published
2022

22. Prevalence of questionable research practices, research misconduct and their potential explanatory factors: A survey among academic researchers in the Netherlands

Author

Leerstoel van Buuren, Methodology and statistics for the behavioural and social sciences, Gopalakrishna, Gowri, ter Riet, Gerben, Vink, Gerko, Stoop, Ineke, Wicherts, Jelte M., Bouter, Lex M., Leerstoel van Buuren, Methodology and statistics for the behavioural and social sciences, Gopalakrishna, Gowri, ter Riet, Gerben, Vink, Gerko, Stoop, Ineke, Wicherts, Jelte M., and Bouter, Lex M.

Published
2022

23. Prevalence of responsible research practices among academics in The Netherlands

Author

Wicherts, Jelte M., Gopalakrishna, Gowri, Vink, Gerko, Stoop, Ineke, Akker, Olmo R. van den, Riet, Gerben ter, Bouter, Lex M., Wicherts, Jelte M., Gopalakrishna, Gowri, Vink, Gerko, Stoop, Ineke, Akker, Olmo R. van den, Riet, Gerben ter, and Bouter, Lex M.

Abstract

Background: Traditionally, research integrity studies have focused on research misbehaviors and their explanations. Over time, attention has shifted towards preventing questionable research practices and promoting responsible ones. However, data on the prevalence of responsible research practices, especially open methods, open codes and open data and their underlying associative factors, remains scarce. Methods: We conducted a web-based anonymized questionnaire, targeting all academic researchers working at or affiliated to a university or university medical center in The Netherlands, to investigate the prevalence and potential explanatory factors of 11 responsible research practices. Results: A total of 6,813 academics completed the survey, the results of which show that prevalence of responsible practices differs substantially across disciplines and ranks, with 99 percent avoiding plagiarism in their work but less than 50 percent pre-registering a research protocol. Arts and humanities scholars as well as PhD candidates and junior researchers engaged less often in responsible research practices. Publication pressure negatively affected responsible practices, while mentoring, scientific norms subscription and funding pressure stimulated them. Conclusions: Understanding the prevalence of responsible research practices across disciplines and ranks, as well as their associated explanatory factors, can help to systematically address disciplinary- and academic rank-specific obstacles, and thereby facilitate responsible conduct of research.

Published
2022

29. Prevalence of responsible research practices and their potential explanatory factors: a survey among academic researchers in The Netherlands

Author

Leerstoel van Buuren, Methodology and statistics for the behavioural and social sciences, Gopalakrishna, Gowri, Wicherts, Jelte M., Vink, Gerko, Stoop, Ineke, Akker, Olmo Van den, Riet, Gerben ter, Bouter, Lex, Leerstoel van Buuren, Methodology and statistics for the behavioural and social sciences, Gopalakrishna, Gowri, Wicherts, Jelte M., Vink, Gerko, Stoop, Ineke, Akker, Olmo Van den, Riet, Gerben ter, and Bouter, Lex

Published
2021

30. Prevalence of questionable research practices, research misconduct and their potential explanatory factors: a survey among academic researchers in The Netherlands

Author

Leerstoel van Buuren, Methodology and statistics for the behavioural and social sciences, Gopalakrishna, Gowri, Riet, Gerben ter, Vink, Gerko, Stoop, Ineke, Wicherts, Jelte M., Bouter, Lex, Leerstoel van Buuren, Methodology and statistics for the behavioural and social sciences, Gopalakrishna, Gowri, Riet, Gerben ter, Vink, Gerko, Stoop, Ineke, Wicherts, Jelte M., and Bouter, Lex

Published
2021

32. Laboratory-acquired severe acute respiratory syndrome

Author

Poh, Lian Lim, Kurp, Asok, Gopalakrishna, Gowri, Kwai Peng Chan, and Wong, Christopher W.

Subjects
Laboratory infections -- Development and progression, Laboratory infections -- Risk factors, Laboratory infections -- Case studies, Severe acute respiratory syndrome -- Development and progression, Severe acute respiratory syndrome -- Risk factors, Severe acute respiratory syndrome -- Case studies
Abstract

The first case of severe acute respiratory syndrome (SARS), to occur in Singapore after the initial worldwide outbreak ended, is presented. Reports showing the transmission of SARS in a laboratory setting are analyzed.

Published
2004

33. SARS transmission and hospital containment

Author

Gopalakrishna, Gowri, Choo, Philip, Leo, Yee Sin, Tay, Boon Keng, Lim, Yean Teng, Khan, Ali S., and Tan, Chorh Chuan

Subjects
Severe acute respiratory syndrome -- Research
Abstract

An outbreak of severe acute respiratory syndrome (SARS) was detected in Singapore at the beginning of March 2003. The outbreak, initiated by a traveler to Hong Kong in late February [...]

Published
2004

35. Brief Report: Laboratory-Acquired Severe Acute Respiratory Syndrome

Author

Lim, Poh Lian, Kurup, Asok, Gopalakrishna, Gowri, Chan, Kwai Peng, Wong, Christopher W., Ng, Lee Ching, Se-Thoe, Su Yun, Oon, Lynette, Bai, Xinlai, Stanton, Lawrence W., Ruan, Yijun, Miller, Lance D., Vega, Vinsensius B., James, Lyn, Ooi, Peng Lim, Kai, Chew Suok, Olsen, Sonja J., Ang, Brenda, and Leo, Yee-Sin.

Published
2004

36. Methods for Evaluating Medical Tests and Biomarkers

Author

Gopalakrishna, Gowri, Langendam, Miranda, Scholten, Rob, Bossuyt, Patrick, Leeflang, Mariska, Noel-Storr, Anna, Thomas, James, Marshall, Iain, Wallace, Byron, Whiting, Penny, Davenport, Clare, GopalaKrishna, Gowri, de Salis, Isabel, Mallett, Sue, Wolff, Robert, Riley, Richard, Westwood, Marie, Kleinen, Jos, Collins, Gary, Reitsma, Hans, Moons, Karel, Zapf, Antonia, Hoyer, Annika, Kramer, Katharina, Kuss, Oliver, Ensor, J., Deeks, J. J., Martin, E. C., Riley, R. D., Rücker, Gerta, Steinhauser, Susanne, Schumacher, Martin, Ensor, Joie, Snell, Kym, Willis, Brian, Debray, Thomas, Deeks, Jon, di Ruffano, Lavinia Ferrante, Taylor-Phillips, Sian, Hyde, Chris, Taylor, Stuart A., Batnagar, Gauraang, Di Ruffano, Lavinia Ferrante, Seedat, Farah, Clarke, Aileen, Byron, Sarah, Nixon, Frances, Albrow, Rebecca, Walker, Thomas, Deakin, Carla, Zhelev, Zhivko, Hunt, Harriet, Yang, Yaling, Abel, Lucy, Buchanan, James, Fanshawe, Thomas, Shinkins, Bethany, Wynants, Laure, Verbakel, Jan, Van Huffel, Sabine, Timmerman, Dirk, Van Calster, Ben, Zwinderman, Aeliko, Oke, Jason, O’Sullivan, Jack, Perera, Rafael, Nicholson, Brian, Bromley, Hannah L., Roberts, Tracy E., Francis, Adele, Petrie, Denniis, Mann, G. Bruce, Malottki, Kinga, Smith, Holly, Billingham, Lucinda, Sitch, Alice, Gerke, Oke, Holm-Vilstrup, Mie, Segtnan, Eivind Antonsen, Halekoh, Ulrich, Høilund-Carlsen, Poul Flemming, Francq, Bernard G., Dinnes, Jac, Parkes, Julie, Gregory, Walter, Hewison, Jenny, Altman, Doug, Rosenberg, William, Selby, Peter, Asselineau, Julien, Perez, Paul, Paye, Aïssatou, Bessede, Emilie, Proust-Lima, Cécile, Naaktgeboren, Christiana, de Groot, Joris, Rutjes, Anne, Reitsma, Johannes, Ogundimu, Emmanuel, Cook, Jonathan, Le Manach, Yannick, Vergouwe, Yvonne, Pajouheshnia, Romin, Groenwold, Rolf, Moons, Karen, Peelen, Linda, Nieboer, Daan, De Cock, Bavo, Pencina, Micael J., Steyerberg, Ewout W., Cooper, Jennifer, Parsons, Nick, Stinton, Chris, Smith, Steve, Dickens, Andy, Jordan, Rachel, Enocson, Alexandra, Fitzmaurice, David, Adab, Peymane, Boachie, Charles, Vidmar, Gaj, Freeman, Karoline, Connock, Martin, Court, Rachel, Moons, Carl, Harris, Jessica, Mumford, Andrew, Plummer, Zoe, Lee, Kurtis, Reeves, Barnaby, Rogers, Chris, Verheyden, Veerle, Angelini, Gianni D., Murphy, Gavin J., Huddy, Jeremy, Ni, Melody, Good, Katherine, Cooke, Graham, Hanna, George, Ma, Jie, Moons, K. G. M. (Carl), de Groot, Joris A. H., Altman, Doug G., Reitsma, Johannes B., Collins, Gary S., Moons, Karel G. M., Altman, Douglas G., Kamarudin, Adina Najwa, Kolamunnage-Dona, Ruwanthi, Cox, Trevor, Borsci, Simone, Pérez, Teresa, Pardo, M.Carmen, Candela-Toha, Angel, Muriel, Alfonso, Zamora, Javier, Sanghera, Sabina, Mohiuddin, Syed, Martin, Richard, Donovan, Jenny, Coast, Joanna, Seo, Mikyung Kelly, Cairns, John, Mitchell, Elizabeth, Smith, Alison, Wright, Judy, Hall, Peter, Messenger, Michael, Calder, Nicola, Wickramasekera, Nyantara, Vinall-Collier, Karen, Lewington, Andrew, Damen, Johanna, Cairns, David, Hutchinson, Michelle, Sturgeon, Cathie, Mitchel, Liz, Kift, Rebecca, Christakoudi, Sofia, Rungall, Manohursingh, Mobillo, Paula, Montero, Rosa, Tsui, Tjir-Li, Kon, Sui Phin, Tucker, Beatriz, Sacks, Steven, Farmer, Chris, Strom, Terry, Chowdhury, Paramit, Rebollo-Mesa, Irene, Hernandez-Fuentes, Maria, Damen, Johanna A. A. G., Debray, Thomas P. A., Heus, Pauline, Hooft, Lotty, Scholten, Rob J. P. M., Schuit, Ewoud, Tzoulaki, Ioanna, Lassale, Camille M., Siontis, George C. M., Chiocchia, Virginia, Roberts, Corran, Schlüssel, Michael Maia, Gerry, Stephen, Black, James A., van der Schouw, Yvonne T., Peelen, Linda M., Spence, Graeme, McCartney, David, van den Bruel, Ann, Lasserson, Daniel, Hayward, Gail, Vach, Werner, de Jong, Antoinette, Burggraaff, Coreline, Hoekstra, Otto, Zijlstra, Josée, de Vet, Henrica, Graziadio, Sara, Allen, Joy, Johnston, Louise, O’Leary, Rachel, Power, Michael, Johnson, Louise, Waters, Ray, Simpson, John, Fanshawe, Thomas R., Phillips, Peter, Plumb, Andrew, Helbren, Emma, Halligan, Steve, Gale, Alastair, Sekula, Peggy, Sauerbrei, Willi, Forman, Julia R., Dutton, Susan J., Takwoingi, Yemisi, Hensor, Elizabeth M., Nichols, Thomas E., Kempf, Emmanuelle, Porcher, Raphael, de Beyer, Jennifer, Altman, Douglas, Hopewell, Sally, Dennis, John, Shields, Beverley, Jones, Angus, Henley, William, Pearson, Ewan, Hattersley, Andrew, Scheibler, Fueloep, Rummer, Anne, Sturtz, Sibylle, Großelfinger, Robert, Banister, Katie, Ramsay, Craig, Azuara-Blanco, Augusto, Burr, Jennifer, Kumarasamy, Manjula, Bourne, Rupert, Uchegbu, Ijeoma, Murphy, Jennifer, Carter, Alex, Murphy, Jen, Marti, Joachim, Eatock, Julie, Robotham, Julie, Dudareva, Maria, Gilchrist, Mark, Holmes, Alison, Monaghan, Phillip, Lord, Sarah, StJohn, Andrew, Sandberg, Sverre, Cobbaert, Christa, Lennartz, Lieselotte, Verhagen-Kamerbeek, Wilma, Ebert, Christoph, Horvath, Andrea, Jenniskens, Kevin, Peters, Jaime, Grigore, Bogdan, Ukoumunne, Obi, Levis, Brooke, Benedetti, Andrea, Levis, Alexander W., Ioannidis, John P. A., Shrier, Ian, Cuijpers, Pim, Gilbody, Simon, Kloda, Lorie A., McMillan, Dean, Patten, Scott B, Steele, Russell J., Ziegelstein, Roy C, Bombardier, Charles H., Osório, Flavia de Lima, Fann, Jesse R., Gjerdingen, Dwenda, Lamers, Femke, Lotrakul, Manote, Loureiro, Sonia R, Löwe, Bernd, Shaaban, Juwita, Stafford, Lesley, van Weert, Henk C. P. M., Whooley, Mary A., Williams, Linda S., Wittkampf, Karin A., Yeung, Albert S., Thombs, Brett D., Cooper, Chris, Nieto, Tom, Smith, Claire, Tucker, Olga, Dretzke, Janine, Beggs, Andrew, Rai, Nirmala, Bayliss, Sue, Stevens, Simon, Mallet, Sue, Sundar, Sudha, Hall, Emma, Porta, Nuria, Estelles, David Lorente, and de Bono, Johann

Subjects
Faecal Immunochemical Test, Chronic Obstructive Pulmonary Disorder, Circulate Tumour Cell Count, Apply Health Research, Meeting Abstracts, Faecal Immunochemical Test Result
Abstract

unKnown

Published
2017

37. Interpreting the evidence-base for making recommendations on medical tests

Author

Gopalakrishna, Gowri, Bossuyt, P.M.M., Scholten, R.J.P.M., Leeflang, M.M.G., Langendam, M.W., Faculteit der Geneeskunde, Bossuyt, Patrick M. M., Scholten, Robertus J. P. M., Leeflang, Mariska M. G., Langendam, Miranda W., and Epidemiology and Data Science

Abstract

The development of medical test evaluation has predominantly focused on evidence around test performance, such as the analytical and clinical sensitivity and specificity of a test, in order to make conclusions on whether a medical test should be recommended for use or not. We argue in this thesis that the evaluation of tests needs to move beyond test performance measures to include questions on the clinical utility (i.e. the value of a test to a patient), in terms of outcomes related to the test results or testing process. The main thrusts of our argument lies in the fact that firstly, a more accurate test does not directly equate to a better test. Take for instance the circumstance when no appropriate treatment is available or one in which the harms of testing with a new test outweigh its benefits. Under such situations, maintaining status quo may be a more preferable option. Secondly, tests are never used in isolation but are always part of a larger context; what we have chosen to call the “test-treatment pathway”. Such a pathway illustrates the sequences of tests before and after that a patient may receive when they undergoing diagnosis for a certain condition. It also includes the downstream clinical management decisions such as re-testing, follow-up testing, a wait and see approach as well treatment options available for the said condition.

Published
2016

40. Circulating antigen tests and urine reagent strips for diagnosis of active schistosomiasis in endemic areas

Author

Epi Methoden Team 4, Circulatory Health, JC onderzoeksprogramma Methodologie, Ochodo, Eleanor A, Gopalakrishna, Gowri, Spek, Bea, Reitsma, Johannes B, van Lieshout, Lisette, Polman, Katja, Lamberton, Poppy, Bossuyt, Patrick M M, Leeflang, Mariska M G, Epi Methoden Team 4, Circulatory Health, JC onderzoeksprogramma Methodologie, Ochodo, Eleanor A, Gopalakrishna, Gowri, Spek, Bea, Reitsma, Johannes B, van Lieshout, Lisette, Polman, Katja, Lamberton, Poppy, Bossuyt, Patrick M M, and Leeflang, Mariska M G

Published
2015

44. Laboratory-Acquired Severe Acute Respiratory Syndrome

Author

Lim, Poh Lian, primary, Kurup, Asok, additional, Gopalakrishna, Gowri, additional, Chan, Kwai Peng, additional, Wong, Christopher W., additional, Ng, Lee Ching, additional, Se-Thoe, Su Yun, additional, Oon, Lynette, additional, Bai, Xinlai, additional, Stanton, Lawrence W., additional, Ruan, Yijun, additional, Miller, Lance D., additional, Vega, Vinsensius B., additional, James, Lyn, additional, Ooi, Peng Lim, additional, Kai, Chew Suok, additional, Olsen, Sonja J., additional, Ang, Brenda, additional, and Leo, Yee-Sin, additional

Published
2004
Full Text
View/download PDF

45. The role of Chlamydia pneumoniae in acute respiratory tract infections in young children in The Gambia, West Africa.

Author

Weber, Martin W., Gopalakrishna, Gowri, Awomoyi, Agnes, Cunningham, Adam, Adegbola, Richard A., Falade, Adegoke G., Ogunlesi, Olayinka O., Whittle, Hilton C., and Mulholland, Kim E.

Subjects
*PEDIATRIC research, *CHLAMYDOPHILA pneumoniae, *ETIOLOGY of diseases, *RESPIRATORY infections, *CHILDREN, *SYMPTOMS, *POLYMERASE chain reaction, DEVELOPING countries
Abstract

Background: Little is known about the role of Chlamydia pneumoniae in the aetiology of acute respiratory tract infections (ARI) in children in developing countries. Aims: To obtain better information, we studied the presence of C. pneumoniae and its association with clinical signs and symptoms of ARI in children under 5 years of age in The Gambia. Methods: C. pneumoniae was sought by polymerase chain reaction in nasopharyngeal secretions and/or lung puncture aspirates from 324 infants under 3 months of age and 325 children between 3 months and 5 years of age with malnutrition, with or without pneumonia, and in control children. Clinical signs and symptoms for ARI and the spectrum of other viral and bacterial organisms were compared between those positive for C. pneumoniae and those negative. Results: Of 324 young infants, ten (3.1%) showed the presence of C. pneumoniae whereas in the older children 50 of 325 (15%) were positive for C. pneumoniae. There was no significant association between clinical signs and symptoms of ARI and C. pneumoniae positivity in the young infants. Among older infants and children, there was a trend to more frequent lobar alveolar changes in those positive for C. pneumoniae. No bacterial pathogens were found to be significantly associated with C. pneumoniae infection. However, there was an association with measles in the malnutrition group and with RSV in the young infants group. Conclusions: In this study, C. pneumoniae was not associated with any particular clinical syndrome. We found no evidence that the organism plays a major role in ARI in young children in developing countries such as The Gambia. [ABSTRACT FROM AUTHOR]

Published
2006
Full Text
View/download PDF

46. Scoping review and evidence mapping of interventions aimed at improving reproducible and replicable science: Protocol.

Author

Dudda LA, Kozula M, Ross-Hellauer T, Kormann E, Spijker R, DeVito N, Gopalakrishna G, Van den Eynden V, Onghena P, Naudet F, Banzi R, Fratelli M, Varga M, Gelsleichter YA, Stegeman I, and Leeflang MM

Abstract

Background: Many interventions, especially those linked to open science, have been proposed to improve reproducibility in science. To what extent these propositions are based on scientific evidence from empirical evaluations is not clear., Aims: The primary objective is to identify Open Science interventions that have been formally investigated regarding their influence on reproducibility and replicability. A secondary objective is to list any facilitators or barriers reported and to identify gaps in the evidence., Methods: We will search broadly by using electronic bibliographic databases, broad internet search, and contacting experts in the field of reproducibility, replicability, and open science. Any study investigating interventions for their influence on the reproducibility and replicability of research will be selected, including those studies additionally investigating drivers and barriers to the implementation and effectiveness of interventions. Studies will first be selected by title and abstract (if available) and then by reading the full text by at least two independent reviewers. We will analyze existing scientific evidence using scoping review and evidence gap mapping methodologies., Results: The results will be presented in interactive evidence maps, summarized in a narrative synthesis, and serve as input for subsequent research., Review Registration: This protocol has been pre-registered on OSF under doi https://doi.org/10.17605/OSF.IO/D65YS., Competing Interests: No competing interests were disclosed., (Copyright: © 2024 Dudda LA et al.)

Published
2024
Full Text
View/download PDF

48. Aligning the principles and practice of research integrity and research fairness in global health: a mixed-methods study.

Author

Sempa JB, Patil R, Mathewson JD, Kabelka H, Yaghmaei N, Coleman H, Sohoni P, Straetemans M, Gopalakrishna G, Wienia M, Kombe F, and Alba S

Subjects
Humans, Reproducibility of Results, Global Health
Abstract

Introduction: In the past decade, global health research has seen a growing emphasis on research integrity and fairness. The concept of research integrity emerged in response to the reproducibility crisis in science during the late 2000s. Research fairness initiatives aim to enhance ownership and inclusivity in research involving partners with varying powers, decision-making roles and resource capacities, ultimately prioritising local health research needs. Despite extensive academic discussions, empirical data on these aspects, especially in the context of global health, remain limited., Methods: To address this gap, we conducted a mixed-methods study focusing on research integrity and fairness. The study included an online frequency survey and in-depth key informant interviews with researchers from international research networks. The dual objectives were to quantify the frequency of practices related to research integrity and fairness and explore the determinants influencing these practices in global health., Results: Out of 145 participants in the quantitative survey (8.4% response rate), findings indicate that global health researchers generally adhere to principles of research integrity and fairness, with variations in reported behaviours. The study identified structural, institutional and individual factors influencing these patterns, including donor landscape rigidity, institutional investments in relationship building, guidelines, mentoring and power differentials among researchers., Conclusion: This research highlights that, despite some variations, there is a substantial alignment between research integrity and fairness, with both sharing similar determinants and the overarching goal of enhancing research quality and societal benefits. The study emphasises the potential to explicitly recognise and leverage these synergies, aligning both agendas to further advance global health research., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2024
Full Text
View/download PDF

49. Erratum to: Methods for evaluating medical tests and biomarkers.

Author

Gopalakrishna G, Langendam M, Scholten R, Bossuyt P, Leeflang M, Noel-Storr A, Thomas J, Marshall I, Wallace B, Whiting P, Davenport C, Leeflang M, GopalaKrishna G, de Salis I, Mallett S, Wolff R, Whiting P, Riley R, Westwood M, Kleinen J, Collins G, Reitsma H, Moons K, Zapf A, Hoyer A, Kramer K, Kuss O, Ensor J, Deeks JJ, Martin EC, Riley RD, Rücker G, Steinhauser S, Schumacher M, Riley R, Ensor J, Snell K, Willis B, Debray T, Moons K, Deeks J, Collins G, di Ruffano LF, Willis B, Davenport C, Mallett S, Taylor-Phillips S, Hyde C, Deeks J, Mallett S, Taylor SA, Batnagar G, Taylor-Phillips S, Di Ruffano LF, Seedat F, Clarke A, Deeks J, Byron S, Nixon F, Albrow R, Walker T, Deakin C, Hyde C, Zhelev Z, Hunt H, di Ruffano LF, Yang Y, Abel L, Buchanan J, Fanshawe T, Shinkins B, Wynants L, Verbakel J, Van Huffel S, Timmerman D, Van Calster B, Leeflang M, Zwinderman A, Bossuyt P, Oke J, O'Sullivan J, Perera R, Nicholson B, Bromley HL, Roberts TE, Francis A, Petrie D, Mann GB, Malottki K, Smith H, Deeks J, Billingham L, Sitch A, Mallett S, Deeks J, Gerke O, Holm-Vilstrup M, Segtnan EA, Halekoh U, Høilund-Carlsen PF, Francq BG, Deeks J, Sitch A, Dinnes J, Parkes J, Gregory W, Hewison J, Altman D, Rosenberg W, Selby P, Asselineau J, Perez P, Paye A, Bessede E, Proust-Lima C, Naaktgeboren C, de Groot J, Rutjes A, Bossuyt P, Reitsma J, Moons K, Collins G, Ogundimu E, Cook J, Le Manach Y, Altman D, Wynants L, Vergouwe Y, Van Huffel S, Timmerman D, Van Calster B, Pajouheshnia R, Groenwold R, Moons K, Reitsma J, Peelen L, Van Calster B, Nieboer D, Vergouwe Y, De Cock B, Pencina MJ, Steyerberg EW, Cooper J, Taylor-Phillips S, Parsons N, Stinton C, Smith S, Dickens A, Jordan R, Enocson A, Fitzmaurice D, Sitch A, Adab P, Francq BG, Boachie C, Vidmar G, Freeman K, Connock M, Taylor-Phillips S, Court R, Clarke A, de Groot J, Naaktgeboren C, Reitsma H, Moons C, Harris J, Mumford A, Plummer Z, Lee K, Reeves B, Rogers C, Verheyden V, Angelini GD, Murphy GJ, Huddy J, Ni M, Good K, Cooke G, Bossuyt P, Hanna G, Ma J, Altman D, Collins G, Moons KGMC, de Groot JAH, Mallett S, Altman DG, Reitsma JB, Collins GS, Moons KGM, Altman DG, Reitsma JB, Collins GS, Kamarudin AN, Kolamunnage-Dona R, Cox T, Ni M, Huddy J, Borsci S, Hanna G, Pérez T, Pardo MC, Candela-Toha A, Muriel A, Zamora J, Sanghera S, Mohiuddin S, Martin R, Donovan J, Coast J, Seo MK, Cairns J, Mitchell E, Smith A, Wright J, Hall P, Messenger M, Calder N, Wickramasekera N, Vinall-Collier K, Lewington A, Pajouheshnia R, Damen J, Groenwold R, Moons K, Peelen L, Messenger M, Cairns D, Smith A, Hutchinson M, Wright J, Hall P, Calder N, Sturgeon C, Mitchel L, Kift R, Christakoudi S, Rungall M, Mobillo P, Montero R, Tsui TL, Kon SP, Tucker B, Sacks S, Farmer C, Strom T, Chowdhury P, Rebollo-Mesa I, Hernandez-Fuentes M, Damen JAAG, Debray TPA, Heus P, Hooft L, Moons KGM, Pajouheshnia R, Reitsma JB, Scholten RJPM, Damen JAAG, Hooft L, Schuit E, Debray TPA, Collins GS, Tzoulaki I, Lassale CM, Siontis GCM, Chiocchia V, Roberts C, Schlüssel MM, Gerry S, Black JA, Heus P, van der Schouw YT, Peelen LM, Moons KGM, Damen JAAG, Debray TPA, Heus P, Hooft L, Moons KGM, Pajouheshnia R, Reitsma JB, Scholten RJPM, Ma J, Altman D, Collins G, Spence G, McCartney D, van den Bruel A, Lasserson D, Hayward G, Vach W, de Jong A, Burggraaff C, Hoekstra O, Zijlstra J, de Vet H, Hunt H, Hyde C, Graziadio S, Allen J, Johnston L, O'Leary R, Power M, Allen J, Graziadio S, Johnson L, O'Leary R, Power M, Waters R, Simpson J, Johnston L, Allen J, Graziadio S, O'Leary R, Waters R, Power M, Mallett S, Fanshawe TR, Phillips P, Plumb A, Helbren E, Halligan S, Taylor SA, Gale A, Mallett S, Sekula P, Altman DG, Sauerbrei W, Mallett S, Fanshawe TR, Forman JR, Dutton SJ, Takwoingi Y, Hensor EM, Nichols TE, Shinkins B, Yang Y, Abel L, Di Ruffano LF, Fanshawe T, Kempf E, Porcher R, de Beyer J, Moons K, Altman D, Reitsma H, Hopewell S, Sauerbrei W, Collins G, Dennis J, Shields B, Jones A, Henley W, Pearson E, Hattersley A, Heus P, Damen JAAG, Pajouheshnia R, Scholten RJPM, Reitsma JB, Collins GS, Altman DG, Moons KGM, Hooft L, Shields B, Dennis J, Jones A, Henley W, Pearson E, Hattersley A, Scheibler F, Rummer A, Sturtz S, Großelfinger R, Banister K, Ramsay C, Azuara-Blanco A, Cook J, Boachie C, Burr J, Kumarasamy M, Bourne R, Uchegbu I, Borsci S, Murphy J, Hanna G, Uchegbu I, Carter A, Murphy J, Ni M, Marti J, Eatock J, Uchegbu I, Robotham J, Dudareva M, Gilchrist M, Holmes A, Uchegbu I, Borsci S, Monaghan P, Lord S, StJohn A, Sandberg S, Cobbaert C, Lennartz L, Verhagen-Kamerbeek W, Ebert C, Bossuyt P, Horvath A, Jenniskens K, Naaktgeboren C, Reitsma J, Moons K, de Groot J, Hyde C, Peters J, Grigore B, Peters J, Hyde C, Hyde C, Ukoumunne O, Peters J, Zhelev Z, Levis B, Benedetti A, Levis AW, Ioannidis JPA, Shrier I, Cuijpers P, Gilbody S, Kloda LA, McMillan D, Patten SB, Steele RJ, Ziegelstein RC, Bombardier CH, Osório FL, Fann JR, Gjerdingen D, Lamers F, Lotrakul M, Loureiro SR, Löwe B, Shaaban J, Stafford L, van Weert HCPM, Whooley MA, Williams LS, Wittkampf KA, Yeung AS, Thombs BD, Peters J, Cooper C, Buchanan J, Nieto T, Smith C, Tucker O, Dretzke J, Beggs A, Rai N, Davenport C, Bayliss S, Stevens S, Snell K, Mallet S, Deeks J, Sundar S, Hall E, Porta N, Estelles DL, and de Bono J

Abstract

[This corrects the article DOI: 10.1186/s41512-016-0001-y.].

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results