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9 results on '"Goon, Leanne"'

1. Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors

Author

Parr, Brendan T., primary, Pastor, Richard, additional, Sellers, Benjamin D., additional, Pei, Zhonghua, additional, Jaipuri, Firoz A., additional, Castanedo, Georgette M., additional, Gazzard, Lewis, additional, Kumar, Sanjeev, additional, Li, Xiaokai, additional, Liu, Wen, additional, Mendonca, Rohan, additional, Pavana, Roheeth K., additional, Potturi, Hima, additional, Shao, Cheng, additional, Velvadapu, Venkata, additional, Waldo, Jesse P., additional, Wu, Guosheng, additional, Yuen, Po-wai, additional, Zhang, Zuhui, additional, Zhang, Yamin, additional, Harris, Seth F., additional, Oh, Angela J., additional, DiPasquale, Antonio, additional, Dement, Kevin, additional, La, Hank, additional, Goon, Leanne, additional, Gustafson, Amy, additional, VanderPorten, Erica C., additional, Mautino, Mario R., additional, and Liu, Yichin, additional

Published
2020
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2. Antibody–Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo

Author

Su, Dian, primary, Chen, Jinhua, additional, Cosino, Ely, additional, dela Cruz-Chuh, Josefa, additional, Davis, Helen, additional, Del Rosario, Geoffrey, additional, Figueroa, Isabel, additional, Goon, Leanne, additional, He, Jintang, additional, Kamath, Amrita V., additional, Kaur, Surinder, additional, Kozak, Katherine R., additional, Lau, Jeffrey, additional, Lee, Donna, additional, Lee, M. Violet, additional, Leipold, Douglas, additional, Liu, Luna, additional, Liu, Peter, additional, Lu, Guo-Liang, additional, Nelson, Chris, additional, Ng, Carl, additional, Pillow, Thomas H., additional, Polakis, Paul, additional, Polson, Andrew G., additional, Rowntree, Rebecca K., additional, Saad, Ola, additional, Safina, Brian, additional, Stagg, Nicola J., additional, Tercel, Moana, additional, Vandlen, Richard, additional, Vollmar, Breanna S., additional, Wai, John, additional, Wang, Tao, additional, Wei, BinQing, additional, Xu, Keyang, additional, Xue, Juanjuan, additional, Xu, Zijin, additional, Yan, Gang, additional, Yao, Hui, additional, Yu, Shang-Fan, additional, Zhang, Donglu, additional, Zhong, Fiona, additional, and Dragovich, Peter S., additional

Published
2019
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3. Aminoisoxazoles as Potent Inhibitors of Tryptophan 2,3-Dioxygenase 2 (TDO2)

Author

Pei, Zhonghua, primary, Mendonca, Rohan, additional, Gazzard, Lewis, additional, Pastor, Richard, additional, Goon, Leanne, additional, Gustafson, Amy, additional, VanderPorten, Erica, additional, Hatzivassiliou, Georgia, additional, Dement, Kevin, additional, Cass, Robert, additional, Yuen, Po-wai, additional, Zhang, Yamin, additional, Wu, Guosheng, additional, Lin, Xingyu, additional, Liu, Yichin, additional, and Sellers, Benjamin D., additional

Published
2018
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4. In Vitro and In Vivo Activity of Cabozantinib (XL184), an Inhibitor of RET, MET, and VEGFR2, in a Model of Medullary Thyroid Cancer

Author

Bentzien, Frauke, primary, Zuzow, Marcus, additional, Heald, Nathan, additional, Gibson, Anna, additional, Shi, Yongchang, additional, Goon, Leanne, additional, Yu, Peiwen, additional, Engst, Stefan, additional, Zhang, Wentao, additional, Huang, Donghui, additional, Zhao, Lora, additional, Vysotskaia, Valentina, additional, Chu, Felix, additional, Bautista, Rajana, additional, Cancilla, Belinda, additional, Lamb, Peter, additional, Joly, Alison H., additional, and Yakes, F. Michael, additional

Published
2013
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5. Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase γ Inhibitors

Author

Leahy, James W., primary, Buhr, Chris A., additional, Johnson, Henry W. B., additional, Kim, Byung Gyu, additional, Baik, TaeGon, additional, Cannoy, Jonah, additional, Forsyth, Timothy P., additional, Jeong, Joon Won, additional, Lee, Matthew S., additional, Ma, Sunghoon, additional, Noson, Kevin, additional, Wang, Longcheng, additional, Williams, Matthew, additional, Nuss, John M., additional, Brooks, Eric, additional, Foster, Paul, additional, Goon, Leanne, additional, Heald, Nathan, additional, Holst, Charles, additional, Jaeger, Christopher, additional, Lam, Scott, additional, Lougheed, Julie, additional, Nguyen, Lam, additional, Plonowski, Arthur, additional, Song, Joanne, additional, Stout, Thomas, additional, Wu, Xiang, additional, Yakes, Michael F., additional, Yu, Peiwen, additional, Zhang, Wentao, additional, Lamb, Peter, additional, and Raeber, Olivia, additional

Published
2012
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6. Correction: High-Content, High-Throughput Analysis of Cell Cycle Perturbations Induced by the HSP90 Inhibitor XL888

Author

Lyman, Susan K., primary, Crawley, Suzanne C., additional, Gong, Ruoyu, additional, Adamkewicz, Joanne I., additional, McGrath, Garth, additional, Chew, Jason Y., additional, Choi, Jennifer, additional, Holst, Charles R., additional, Goon, Leanne H., additional, Detmer, Scott A., additional, Vaclavikova, Jana, additional, Gerritsen, Mary E., additional, and Blake, Robert A., additional

Published
2011
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7. High-Content, High-Throughput Analysis of Cell Cycle Perturbations Induced by the HSP90 Inhibitor XL888

Author

Lyman, Susan K., primary, Crawley, Suzanne C., additional, Gong, Ruoyu, additional, Adamkewicz, Joanne I., additional, McGrath, Garth, additional, Chew, Jason Y., additional, Choi, Jennifer, additional, Holst, Charles R., additional, Goon, Leanne H., additional, Detmer, Scott A., additional, Vaclavikova, Jana, additional, Gerritsen, Mary E., additional, and Blake, Robert A., additional

Published
2011
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9. Lysosomal Ca(2+) stores in bovine corneal endothelium.

Author

Srinivas SP, Ong A, Goon L, Goon L, and Bonanno JA

Subjects
Acridine Orange, Animals, Cattle, Cells, Cultured, Dipeptides pharmacology, Endothelium, Corneal drug effects, Fluorescent Dyes, Hydrogen-Ion Concentration, Inositol 1,4,5-Trisphosphate metabolism, Lysosomes drug effects, Uridine Triphosphate pharmacology, Calcium metabolism, Endothelium, Corneal metabolism, Fura-2 analogs & derivatives, Lysosomes metabolism
Abstract

Purpose: Acidic organelles, including Golgi bodies and lysosomes, are known to operate as Ca(2+) storage sites in many cell types. This study demonstrates the presence of Ca(2+) stores in lysosomes of bovine corneal endothelial cells (BCECs) and examines their interaction with Ins(1,4,5)P(3)-sensitive Ca(2+) stores., Methods: Glycyl-L-phenylalanine-beta-naphthylamide (GPN) was used to release Ca(2+) from lysosomes by inducing their selective osmotic swelling. Ca(2+) released into the cytoplasm was measured with fura-2 or fura-PE3 fluorescent dyes. Fluorescence of acridine orange (AO), which selectively sequesters into acidic organelles, was used to establish swelling of lysosomes in response to GPN., Results: Exposure to GPN (100-200 microM) in cultured BCECs produced an increase in free cytosolic Ca(2+) ([Ca(2+)](i)) equivalent to approximately 79% of the peak response to uridine triphosphate (UTP), a P2Y agonist (n = 19). The endothelium of the freshly isolated cornea also produced [Ca(2+)](i) transients similar to those in cultured BCECs; however, the peak [Ca(2+)](i) increase was smaller ( approximately 43% of the peak response to UTP; n = 13). In cultured BCECs, the response to UTP was unaffected by pretreatment with GPN with extracellular calcium ([Ca(2+)](o)) at 0 and 1.2 mM (n = 10). Neither pretreatment with thapsigargin (5 microM) nor with U73122 (a phospholipase C inhibitor; 10 microM) blocked the peak GPN response (n = 6). Exposure to 20 microM monensin produced a [Ca(2+)](i) increase with [Ca(2+)](o) at 0 and 1.2 mM and also reduced the subsequent peak response to GPN (n = 6)., Conclusions: GPN-sensitive lysosomal Ca(2+) stores, distinct from Ins(1,4,5)P(3)-sensitive Ca(2+) stores, are found in both cultured cells and fresh tissue. These stores are susceptible to depletion by the loss of the pH gradient across lysosomes and P2 agonists. The latter occurs through mechanisms independent of phospholipase C (PLC) activation or Ins(1,4,5)P(3). The GPN stores also induce [Ca(2+)](o) influx in response to their depletion.

Published
2002

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