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2. The Concise Guide to PHARMACOLOGY 2023/24 : G protein-coupled receptors
- Author
-
Alexander, Stephen P. H., Christopoulos, Arthur, Davenport, Anthony P., Kelly, Eamonn, Mathie, Alistair A., Peters, John A., Veale, Emma L., Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Davies, Jamie A., Abbracchio, Maria Pia, Abraham, George, Agoulnik, Alexander, Alexander, Wayne, Al-hosaini, Khaled, Baeck, Magnus, Baker, Jillian G., Barnes, Nicholas M., Bathgate, Ross, Beaulieu, Jean-Martin, Beck-Sickinger, Annette G., Behrens, Maik, Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel J. M., Blaho, Victoria, Boulay, Francois, Bousquet, Corinne, Braeuner-Osborne, Hans, Burnstock, Geoffrey, Calo, Girolamo, Castano, Justo P., Catt, Kevin J., Ceruti, Stefania, Chazot, Paul, Chiang, Nan, Chini, Bice, Chun, Jerold, Cianciulli, Antonia, Civelli, Olivier, Clapp, Lucie H., Couture, Rejean, Cox, Helen M., Csaba, Zsolt, Dahlgren, Claes, Dent, Gordon, Douglas, Steven D., Dournaud, Pascal, Eguchi, Satoru, Escher, Emanuel, Filardo, Edward J., Fong, Tung, Fumagalli, Marta, Gainetdinov, Raul R., Garelja, Michael L., de Gasparo, Marc, Gerard, Craig, Gershengorn, Marvin, Gobeil, Fernand, Goodfriend, Theodore L., Goudet, Cyril, Graetz, Lukas, Gregory, Karen J., Gundlach, Andrew L., Hamann, Joerg, Hanson, Julien, Hauger, Richard L., Hay, Debbie L., Heinemann, Akos, Herr, Deron, Hollenberg, Morley D., Holliday, Nicholas D., Horiuchi, Mastgugu, Hoyer, Daniel, Hunyady, Laszlo, Husain, Ahsan, Ijzerman, Adriaan P., Inagami, Tadashi, Jacobson, Kenneth A., Jensen, Robert T., Jockers, Ralf, Jonnalagadda, Deepa, Karnik, Sadashiva, Kaupmann, Klemens, Kemp, Jacqueline, Kennedy, Charles, Kihara, Yasuyuki, Kitazawa, Takio, Kozielewicz, Pawel, Kreienkamp, Hans-Juergen, Kukkonen, Jyrki P., Langenhan, Tobias, Larhammar, Dan, Leach, Katie, Lecca, Davide, Lee, John D., Leeman, Susan E., Leprince, Jerome, Li, Xaria X., Lolait, Stephen J., Lupp, Amelie, Macrae, Robyn, Maguire, Janet, Malfacini, Davide, Mazella, Jean, Mcardle, Craig A., Melmed, Shlomo, Michel, Martin C., Miller, Laurence J., Mitolo, Vincenzo, Mouillac, Bernard, Mueller, Christa E., Murphy, Philip M., Nahon, Jean-Louis, Ngo, Tony, Norel, Xavier, Nyimanu, Duuamene, O'Carroll, Anne-Marie, Offermanns, Stefan, Panaro, Maria Antonietta, Parmentier, Marc, Pertwee, Roger G., Pin, Jean-Philippe, Prossnitz, Eric R., Quinn, Mark, Ramachandran, Rithwik, Ray, Manisha, Reinscheid, Rainer K., Rondard, Philippe, Rovati, G. Enrico, Ruzza, Chiara, Sanger, Gareth J., Schoeneberg, Torsten, Schulte, Gunnar, Schulz, Stefan, Segaloff, Deborah L., Serhan, Charles N., Singh, Khuraijam Dhanachandra, Smith, Craig M., Stoddart, Leigh A., Sugimoto, Yukihiko, Summers, Roger, Tan, Valerie P., Thal, David, Thomas, Walter ( Wally), Timmermans, Pieter B. M. W. M., Tirupula, Kalyan, Toll, Lawrence, Tulipano, Giovanni, Unal, Hamiyet, Unger, Thomas, Valant, Celine, Vanderheyden, Patrick, Vaudry, David, Vaudry, Hubert, Vilardaga, Jean-Pierre, Walker, Christopher S., Wang, Ji Ming, Ward, Donald T., Wester, Hans-Juergen, Willars, Gary B., Williams, Tom Lloyd, Woodruff, Trent M., Yao, Chengcan, Ye, Richard D., Alexander, Stephen P. H., Christopoulos, Arthur, Davenport, Anthony P., Kelly, Eamonn, Mathie, Alistair A., Peters, John A., Veale, Emma L., Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Davies, Jamie A., Abbracchio, Maria Pia, Abraham, George, Agoulnik, Alexander, Alexander, Wayne, Al-hosaini, Khaled, Baeck, Magnus, Baker, Jillian G., Barnes, Nicholas M., Bathgate, Ross, Beaulieu, Jean-Martin, Beck-Sickinger, Annette G., Behrens, Maik, Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel J. M., Blaho, Victoria, Boulay, Francois, Bousquet, Corinne, Braeuner-Osborne, Hans, Burnstock, Geoffrey, Calo, Girolamo, Castano, Justo P., Catt, Kevin J., Ceruti, Stefania, Chazot, Paul, Chiang, Nan, Chini, Bice, Chun, Jerold, Cianciulli, Antonia, Civelli, Olivier, Clapp, Lucie H., Couture, Rejean, Cox, Helen M., Csaba, Zsolt, Dahlgren, Claes, Dent, Gordon, Douglas, Steven D., Dournaud, Pascal, Eguchi, Satoru, Escher, Emanuel, Filardo, Edward J., Fong, Tung, Fumagalli, Marta, Gainetdinov, Raul R., Garelja, Michael L., de Gasparo, Marc, Gerard, Craig, Gershengorn, Marvin, Gobeil, Fernand, Goodfriend, Theodore L., Goudet, Cyril, Graetz, Lukas, Gregory, Karen J., Gundlach, Andrew L., Hamann, Joerg, Hanson, Julien, Hauger, Richard L., Hay, Debbie L., Heinemann, Akos, Herr, Deron, Hollenberg, Morley D., Holliday, Nicholas D., Horiuchi, Mastgugu, Hoyer, Daniel, Hunyady, Laszlo, Husain, Ahsan, Ijzerman, Adriaan P., Inagami, Tadashi, Jacobson, Kenneth A., Jensen, Robert T., Jockers, Ralf, Jonnalagadda, Deepa, Karnik, Sadashiva, Kaupmann, Klemens, Kemp, Jacqueline, Kennedy, Charles, Kihara, Yasuyuki, Kitazawa, Takio, Kozielewicz, Pawel, Kreienkamp, Hans-Juergen, Kukkonen, Jyrki P., Langenhan, Tobias, Larhammar, Dan, Leach, Katie, Lecca, Davide, Lee, John D., Leeman, Susan E., Leprince, Jerome, Li, Xaria X., Lolait, Stephen J., Lupp, Amelie, Macrae, Robyn, Maguire, Janet, Malfacini, Davide, Mazella, Jean, Mcardle, Craig A., Melmed, Shlomo, Michel, Martin C., Miller, Laurence J., Mitolo, Vincenzo, Mouillac, Bernard, Mueller, Christa E., Murphy, Philip M., Nahon, Jean-Louis, Ngo, Tony, Norel, Xavier, Nyimanu, Duuamene, O'Carroll, Anne-Marie, Offermanns, Stefan, Panaro, Maria Antonietta, Parmentier, Marc, Pertwee, Roger G., Pin, Jean-Philippe, Prossnitz, Eric R., Quinn, Mark, Ramachandran, Rithwik, Ray, Manisha, Reinscheid, Rainer K., Rondard, Philippe, Rovati, G. Enrico, Ruzza, Chiara, Sanger, Gareth J., Schoeneberg, Torsten, Schulte, Gunnar, Schulz, Stefan, Segaloff, Deborah L., Serhan, Charles N., Singh, Khuraijam Dhanachandra, Smith, Craig M., Stoddart, Leigh A., Sugimoto, Yukihiko, Summers, Roger, Tan, Valerie P., Thal, David, Thomas, Walter ( Wally), Timmermans, Pieter B. M. W. M., Tirupula, Kalyan, Toll, Lawrence, Tulipano, Giovanni, Unal, Hamiyet, Unger, Thomas, Valant, Celine, Vanderheyden, Patrick, Vaudry, David, Vaudry, Hubert, Vilardaga, Jean-Pierre, Walker, Christopher S., Wang, Ji Ming, Ward, Donald T., Wester, Hans-Juergen, Willars, Gary B., Williams, Tom Lloyd, Woodruff, Trent M., Yao, Chengcan, and Ye, Richard D.
- Abstract
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at . G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
- Published
- 2023
- Full Text
- View/download PDF
3. The Concise Guide to PHARMACOLOGY 2023/24:G protein-coupled receptors
- Author
-
Alexander, Stephen P H, Christopoulos, Arthur, Davenport, Anthony P, Kelly, Eamonn, Mathie, Alistair A, Peters, John A, Veale, Emma L, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Davies, Jamie A, Abbracchio, Maria Pia, Abraham, George, Agoulnik, Alexander, Alexander, Wayne, Al-Hosaini, Khaled, Bäck, Magnus, Baker, Jillian G, Barnes, Nicholas M, Bathgate, Ross, Beaulieu, Jean-Martin, Beck-Sickinger, Annette G, Behrens, Maik, Bernstein, Kenneth E, Bettler, Bernhard, Birdsall, Nigel J M, Blaho, Victoria, Boulay, Francois, Bousquet, Corinne, Bräuner-Osborne, Hans, Burnstock, Geoffrey, Caló, Girolamo, Castaño, Justo P, Catt, Kevin J, Ceruti, Stefania, Chazot, Paul, Chiang, Nan, Chini, Bice, Chun, Jerold, Cianciulli, Antonia, Civelli, Olivier, Clapp, Lucie H, Couture, Réjean, Cox, Helen M, Csaba, Zsolt, Dahlgren, Claes, Dent, Gordon, Douglas, Steven D, Dournaud, Pascal, Eguchi, Satoru, Escher, Emanuel, Filardo, Edward J, Fong, Tung, Fumagalli, Marta, Gainetdinov, Raul R, Garelja, Michael L, de Gasparo, Marc, Gerard, Craig, Gershengorn, Marvin, Gobeil, Fernand, Goodfriend, Theodore L, Goudet, Cyril, Grätz, Lukas, Gregory, Karen J, Gundlach, Andrew L, Hamann, Jörg, Hanson, Julien, Hauger, Richard L, Hay, Debbie L, Heinemann, Akos, Herr, Deron, Hollenberg, Morley D, Holliday, Nicholas D, Horiuchi, Mastgugu, Hoyer, Daniel, Hunyady, László, Husain, Ahsan, IJzerman, Adriaan P, Inagami, Tadashi, Jacobson, Kenneth A, Jensen, Robert T, Jockers, Ralf, Jonnalagadda, Deepa, Karnik, Sadashiva, Kaupmann, Klemens, Kemp, Jacqueline, Kennedy, Charles, Kihara, Yasuyuki, Kitazawa, Takio, Kozielewicz, Pawel, Kreienkamp, Hans-Jürgen, Kukkonen, Jyrki P, Langenhan, Tobias, Larhammar, Dan, Leach, Katie, Lecca, Davide, Lee, John D, Leeman, Susan E, Leprince, Jérôme, Li, Xaria X, Lolait, Stephen J, Lupp, Amelie, Macrae, Robyn, Maguire, Janet, Malfacini, Davide, Mazella, Jean, McArdle, Craig A, Melmed, Shlomo, Michel, Martin C, Miller, Laurence J, Mitolo, Vincenzo, Mouillac, Bernard, Müller, Christa E, Murphy, Philip M, Nahon, Jean-Louis, Ngo, Tony, Norel, Xavier, Nyimanu, Duuamene, O'Carroll, Anne-Marie, Offermanns, Stefan, Panaro, Maria Antonietta, Parmentier, Marc, Pertwee, Roger G, Pin, Jean-Philippe, Prossnitz, Eric R, Quinn, Mark, Ramachandran, Rithwik, Ray, Manisha, Reinscheid, Rainer K, Rondard, Philippe, Rovati, G Enrico, Ruzza, Chiara, Sanger, Gareth J, Schöneberg, Torsten, Schulte, Gunnar, Schulz, Stefan, Segaloff, Deborah L, Serhan, Charles N, Singh, Khuraijam Dhanachandra, Smith, Craig M, Stoddart, Leigh A, Sugimoto, Yukihiko, Summers, Roger, Tan, Valerie P, Thal, David, Thomas, Walter Wally, Timmermans, Pieter B M W M, Tirupula, Kalyan, Toll, Lawrence, Tulipano, Giovanni, Unal, Hamiyet, Unger, Thomas, Valant, Celine, Vanderheyden, Patrick, Vaudry, David, Vaudry, Hubert, Vilardaga, Jean-Pierre, Walker, Christopher S, Wang, Ji Ming, Ward, Donald T, Wester, Hans-Jürgen, Willars, Gary B, Williams, Tom Lloyd, Woodruff, Trent M, Yao, Chengcan, Ye, Richard D, Alexander, Stephen P H, Christopoulos, Arthur, Davenport, Anthony P, Kelly, Eamonn, Mathie, Alistair A, Peters, John A, Veale, Emma L, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Davies, Jamie A, Abbracchio, Maria Pia, Abraham, George, Agoulnik, Alexander, Alexander, Wayne, Al-Hosaini, Khaled, Bäck, Magnus, Baker, Jillian G, Barnes, Nicholas M, Bathgate, Ross, Beaulieu, Jean-Martin, Beck-Sickinger, Annette G, Behrens, Maik, Bernstein, Kenneth E, Bettler, Bernhard, Birdsall, Nigel J M, Blaho, Victoria, Boulay, Francois, Bousquet, Corinne, Bräuner-Osborne, Hans, Burnstock, Geoffrey, Caló, Girolamo, Castaño, Justo P, Catt, Kevin J, Ceruti, Stefania, Chazot, Paul, Chiang, Nan, Chini, Bice, Chun, Jerold, Cianciulli, Antonia, Civelli, Olivier, Clapp, Lucie H, Couture, Réjean, Cox, Helen M, Csaba, Zsolt, Dahlgren, Claes, Dent, Gordon, Douglas, Steven D, Dournaud, Pascal, Eguchi, Satoru, Escher, Emanuel, Filardo, Edward J, Fong, Tung, Fumagalli, Marta, Gainetdinov, Raul R, Garelja, Michael L, de Gasparo, Marc, Gerard, Craig, Gershengorn, Marvin, Gobeil, Fernand, Goodfriend, Theodore L, Goudet, Cyril, Grätz, Lukas, Gregory, Karen J, Gundlach, Andrew L, Hamann, Jörg, Hanson, Julien, Hauger, Richard L, Hay, Debbie L, Heinemann, Akos, Herr, Deron, Hollenberg, Morley D, Holliday, Nicholas D, Horiuchi, Mastgugu, Hoyer, Daniel, Hunyady, László, Husain, Ahsan, IJzerman, Adriaan P, Inagami, Tadashi, Jacobson, Kenneth A, Jensen, Robert T, Jockers, Ralf, Jonnalagadda, Deepa, Karnik, Sadashiva, Kaupmann, Klemens, Kemp, Jacqueline, Kennedy, Charles, Kihara, Yasuyuki, Kitazawa, Takio, Kozielewicz, Pawel, Kreienkamp, Hans-Jürgen, Kukkonen, Jyrki P, Langenhan, Tobias, Larhammar, Dan, Leach, Katie, Lecca, Davide, Lee, John D, Leeman, Susan E, Leprince, Jérôme, Li, Xaria X, Lolait, Stephen J, Lupp, Amelie, Macrae, Robyn, Maguire, Janet, Malfacini, Davide, Mazella, Jean, McArdle, Craig A, Melmed, Shlomo, Michel, Martin C, Miller, Laurence J, Mitolo, Vincenzo, Mouillac, Bernard, Müller, Christa E, Murphy, Philip M, Nahon, Jean-Louis, Ngo, Tony, Norel, Xavier, Nyimanu, Duuamene, O'Carroll, Anne-Marie, Offermanns, Stefan, Panaro, Maria Antonietta, Parmentier, Marc, Pertwee, Roger G, Pin, Jean-Philippe, Prossnitz, Eric R, Quinn, Mark, Ramachandran, Rithwik, Ray, Manisha, Reinscheid, Rainer K, Rondard, Philippe, Rovati, G Enrico, Ruzza, Chiara, Sanger, Gareth J, Schöneberg, Torsten, Schulte, Gunnar, Schulz, Stefan, Segaloff, Deborah L, Serhan, Charles N, Singh, Khuraijam Dhanachandra, Smith, Craig M, Stoddart, Leigh A, Sugimoto, Yukihiko, Summers, Roger, Tan, Valerie P, Thal, David, Thomas, Walter Wally, Timmermans, Pieter B M W M, Tirupula, Kalyan, Toll, Lawrence, Tulipano, Giovanni, Unal, Hamiyet, Unger, Thomas, Valant, Celine, Vanderheyden, Patrick, Vaudry, David, Vaudry, Hubert, Vilardaga, Jean-Pierre, Walker, Christopher S, Wang, Ji Ming, Ward, Donald T, Wester, Hans-Jürgen, Willars, Gary B, Williams, Tom Lloyd, Woodruff, Trent M, Yao, Chengcan, and Ye, Richard D
- Abstract
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.16177. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
- Published
- 2023
4. Aldosterone and aldosterone: renin ratio associations with insulin resistance and blood pressure in African Americans
- Author
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Huan, Yonghong, DeLoach, Stephanie, Keith, Scott W., Goodfriend, Theodore L., and Falkner, Bonita
- Published
- 2012
- Full Text
- View/download PDF
5. Possible Interactions Among Fatty Acids, Other Lipids, and Aldosterone in the Hypertension of Obesity
- Author
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Goodfriend, Theodore L, Melmed, Shlomo, editor, Levin, Ellis R., editor, and Nadler, Jerry L., editor
- Published
- 1998
- Full Text
- View/download PDF
6. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors
- Author
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Alexander, Stephen P H, primary, Christopoulos, Arthur, additional, Davenport, Anthony P, additional, Kelly, Eamonn, additional, Mathie, Alistair, additional, Peters, John A, additional, Veale, Emma L, additional, Armstrong, Jane F, additional, Faccenda, Elena, additional, Harding, Simon D, additional, Pawson, Adam J, additional, Southan, Christopher, additional, Davies, Jamie A, additional, Abbracchio, Maria Pia, additional, Alexander, Wayne, additional, Al‐hosaini, Khaled, additional, Bäck, Magnus, additional, Barnes, Nicholas M., additional, Bathgate, Ross, additional, Beaulieu, Jean‐Martin, additional, Bernstein, Kenneth E., additional, Bettler, Bernhard, additional, Birdsall, Nigel J.M., additional, Blaho, Victoria, additional, Boulay, Francois, additional, Bousquet, Corinne, additional, Bräuner‐Osborne, Hans, additional, Burnstock, Geoffrey, additional, Caló, Girolamo, additional, Castaño, Justo P., additional, Catt, Kevin J., additional, Ceruti, Stefania, additional, Chazot, Paul, additional, Chiang, Nan, additional, Chini, Bice, additional, Chun, Jerold, additional, Cianciulli, Antonia, additional, Civelli, Olivier, additional, Clapp, Lucie H., additional, Couture, Réjean, additional, Csaba, Zsolt, additional, Dahlgren, Claes, additional, Dent, Gordon, additional, Singh, Khuraijam Dhanachandra, additional, Douglas, Steven D., additional, Dournaud, Pascal, additional, Eguchi, Satoru, additional, Escher, Emanuel, additional, Filardo, Edward J., additional, Fong, Tung, additional, Fumagalli, Marta, additional, Gainetdinov, Raul R, additional, Gasparo, Marc de, additional, Gerard, Craig, additional, Gershengorn, Marvin, additional, Gobeil, Fernand, additional, Goodfriend, Theodore L., additional, Goudet, Cyril, additional, Gregory, Karen J., additional, Gundlach, Andrew L., additional, Hamann, Jörg, additional, Hanson, Julien, additional, Hauger, Richard L., additional, Hay, Debbie L., additional, Heinemann, Akos, additional, Hollenberg, Morley D., additional, Holliday, Nicholas D., additional, Horiuchi, Mastgugu, additional, Hoyer, Daniel, additional, Hunyady, László, additional, Husain, Ahsan, additional, IJzerman, Adriaan P., additional, Inagami, Tadashi, additional, Jacobson, Kenneth A., additional, Jensen, Robert T., additional, Jockers, Ralf, additional, Jonnalagadda, Deepa, additional, Karnik, Sadashiva, additional, Kaupmann, Klemens, additional, Kemp, Jacqueline, additional, Kennedy, Charles, additional, Kihara, Yasuyuki, additional, Kitazawa, Takio, additional, Kozielewicz, Pawel, additional, Kreienkamp, Hans‐Jürgen, additional, Kukkonen, Jyrki P., additional, Langenhan, Tobias, additional, Leach, Katie, additional, Lecca, Davide, additional, Lee, John D., additional, Leeman, Susan E., additional, Leprince, Jérôme, additional, Li, Xaria X., additional, Williams, Tom Lloyd, additional, Lolait, Stephen J., additional, Lupp, Amelie, additional, Macrae, Robyn, additional, Maguire, Janet, additional, Mazella, Jean, additional, McArdle, Craig A., additional, Melmed, Shlomo, additional, Michel, Martin C., additional, Miller, Laurence J., additional, Mitolo, Vincenzo, additional, Mouillac, Bernard, additional, Müller, Christa E., additional, Murphy, Philip, additional, Nahon, Jean‐Louis, additional, Ngo, Tony, additional, Norel, Xavier, additional, Nyimanu, Duuamene, additional, O’Carroll, Anne‐Marie, additional, Offermanns, Stefan, additional, Panaro, Maria Antonietta, additional, Parmentier, Marc, additional, Pertwee, Roger G., additional, Pin, Jean‐Philippe, additional, Prossnitz, Eric R., additional, Quinn, Mark, additional, Ramachandran, Rithwik, additional, Ray, Manisha, additional, Reinscheid, Rainer K., additional, Rondard, Philippe, additional, Rovati, G. Enrico, additional, Ruzza, Chiara, additional, Sanger, Gareth J., additional, Schöneberg, Torsten, additional, Schulte, Gunnar, additional, Schulz, Stefan, additional, Segaloff, Deborah L., additional, Serhan, Charles N., additional, Stoddart, Leigh A., additional, Sugimoto, Yukihiko, additional, Summers, Roger, additional, Tan, Valerie P., additional, Thal, David, additional, Thomas, Walter (Wally), additional, Timmermans, Pieter B. M. W. M., additional, Tirupula, Kalyan, additional, Tulipano, Giovanni, additional, Unal, Hamiyet, additional, Unger, Thomas, additional, Valant, Celine, additional, Vanderheyden, Patrick, additional, Vaudry, David, additional, Vaudry, Hubert, additional, Vilardaga, Jean‐Pierre, additional, Walker, Christopher S., additional, Wang, Ji Ming, additional, Ward, Donald T., additional, Wester, Hans‐Jürgen, additional, Willars, Gary B, additional, Woodruff, Trent M., additional, Yao, Chengcan, additional, and Ye, Richard D., additional
- Published
- 2021
- Full Text
- View/download PDF
7. Lactic Dehydrogenases: Functions of the Two Types
- Author
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Dawson, David M., Goodfriend, Theodore L., and Kaplan, Nathan O.
- Published
- 1964
8. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22:G protein-coupled receptors
- Author
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Alexander, Stephen Ph, Christopoulos, Arthur, Davenport, Anthony P, Kelly, Eamonn, Mathie, Alistair, Peters, John A, Veale, Emma L, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Davies, Jamie A, Abbracchio, Maria Pia, Alexander, Wayne, Al-Hosaini, Khaled, Bäck, Magnus, Barnes, Nicholas M, Bathgate, Ross, Beaulieu, Jean-Martin, Bernstein, Kenneth E, Bettler, Bernhard, Birdsall, Nigel J M, Blaho, Victoria, Boulay, Francois, Bousquet, Corinne, Bräuner-Osborne, Hans, Burnstock, Geoffrey, Caló, Girolamo, Castaño, Justo P, Catt, Kevin J, Ceruti, Stefania, Chazot, Paul, Chiang, Nan, Chini, Bice, Chun, Jerold, Cianciulli, Antonia, Civelli, Olivier, Clapp, Lucie H, Couture, Réjean, Csaba, Zsolt, Dahlgren, Claes, Dent, Gordon, Singh, Khuraijam Dhanachandra, Douglas, Steven D, Dournaud, Pascal, Eguchi, Satoru, Escher, Emanuel, Filardo, Edward J, Fong, Tung, Fumagalli, Marta, Gainetdinov, Raul R, Gasparo, Marc de, Gerard, Craig, Gershengorn, Marvin, Gobeil, Fernand, Goodfriend, Theodore L, Goudet, Cyril, Gregory, Karen J, Gundlach, Andrew L, Hamann, Jörg, Hanson, Julien, Hauger, Richard L, Hay, Debbie L, Heinemann, Akos, Hollenberg, Morley D, Holliday, Nicholas D, Horiuchi, Mastgugu, Hoyer, Daniel, Hunyady, László, Husain, Ahsan, IJzerman, Adriaan P, Inagami, Tadashi, Jacobson, Kenneth A, Jensen, Robert T, Jockers, Ralf, Jonnalagadda, Deepa, Karnik, Sadashiva, Kaupmann, Klemens, Kemp, Jacqueline, Kennedy, Charles, Kihara, Yasuyuki, Kitazawa, Takio, Kozielewicz, Pawel, Kreienkamp, Hans-Jürgen, Kukkonen, Jyrki P, Langenhan, Tobias, Leach, Katie, Lecca, Davide, Lee, John D, Leeman, Susan E, Leprince, Jérôme, Li, Xaria X, Williams, Tom Lloyd, Lolait, Stephen J, Lupp, Amelie, Macrae, Robyn, Maguire, Janet, Mazella, Jean, McArdle, Craig A, Melmed, Shlomo, Michel, Martin C, Miller, Laurence J, Mitolo, Vincenzo, Mouillac, Bernard, Müller, Christa E, Murphy, Philip, Nahon, Jean-Louis, Ngo, Tony, Norel, Xavier, Nyimanu, Duuamene, O'Carroll, Anne-Marie, Offermanns, Stefan, Panaro, Maria Antonietta, Parmentier, Marc, Pertwee, Roger G, Pin, Jean-Philippe, Prossnitz, Eric R, Quinn, Mark, Ramachandran, Rithwik, Ray, Manisha, Reinscheid, Rainer K, Rondard, Philippe, Rovati, G Enrico, Ruzza, Chiara, Sanger, Gareth J, Schöneberg, Torsten, Schulte, Gunnar, Schulz, Stefan, Segaloff, Deborah L, Serhan, Charles N, Stoddart, Leigh A, Sugimoto, Yukihiko, Summers, Roger, Tan, Valerie P, Thal, David, Thomas, Walter Wally, Timmermans, Pieter B M W M, Tirupula, Kalyan, Tulipano, Giovanni, Unal, Hamiyet, Unger, Thomas, Valant, Celine, Vanderheyden, Patrick, Vaudry, David, Vaudry, Hubert, Vilardaga, Jean-Pierre, Walker, Christopher S, Wang, Ji Ming, Ward, Donald T, Wester, Hans-Jürgen, Willars, Gary B, Woodruff, Trent M, Yao, Chengcan, Ye, Richard D, Alexander, Stephen Ph, Christopoulos, Arthur, Davenport, Anthony P, Kelly, Eamonn, Mathie, Alistair, Peters, John A, Veale, Emma L, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Davies, Jamie A, Abbracchio, Maria Pia, Alexander, Wayne, Al-Hosaini, Khaled, Bäck, Magnus, Barnes, Nicholas M, Bathgate, Ross, Beaulieu, Jean-Martin, Bernstein, Kenneth E, Bettler, Bernhard, Birdsall, Nigel J M, Blaho, Victoria, Boulay, Francois, Bousquet, Corinne, Bräuner-Osborne, Hans, Burnstock, Geoffrey, Caló, Girolamo, Castaño, Justo P, Catt, Kevin J, Ceruti, Stefania, Chazot, Paul, Chiang, Nan, Chini, Bice, Chun, Jerold, Cianciulli, Antonia, Civelli, Olivier, Clapp, Lucie H, Couture, Réjean, Csaba, Zsolt, Dahlgren, Claes, Dent, Gordon, Singh, Khuraijam Dhanachandra, Douglas, Steven D, Dournaud, Pascal, Eguchi, Satoru, Escher, Emanuel, Filardo, Edward J, Fong, Tung, Fumagalli, Marta, Gainetdinov, Raul R, Gasparo, Marc de, Gerard, Craig, Gershengorn, Marvin, Gobeil, Fernand, Goodfriend, Theodore L, Goudet, Cyril, Gregory, Karen J, Gundlach, Andrew L, Hamann, Jörg, Hanson, Julien, Hauger, Richard L, Hay, Debbie L, Heinemann, Akos, Hollenberg, Morley D, Holliday, Nicholas D, Horiuchi, Mastgugu, Hoyer, Daniel, Hunyady, László, Husain, Ahsan, IJzerman, Adriaan P, Inagami, Tadashi, Jacobson, Kenneth A, Jensen, Robert T, Jockers, Ralf, Jonnalagadda, Deepa, Karnik, Sadashiva, Kaupmann, Klemens, Kemp, Jacqueline, Kennedy, Charles, Kihara, Yasuyuki, Kitazawa, Takio, Kozielewicz, Pawel, Kreienkamp, Hans-Jürgen, Kukkonen, Jyrki P, Langenhan, Tobias, Leach, Katie, Lecca, Davide, Lee, John D, Leeman, Susan E, Leprince, Jérôme, Li, Xaria X, Williams, Tom Lloyd, Lolait, Stephen J, Lupp, Amelie, Macrae, Robyn, Maguire, Janet, Mazella, Jean, McArdle, Craig A, Melmed, Shlomo, Michel, Martin C, Miller, Laurence J, Mitolo, Vincenzo, Mouillac, Bernard, Müller, Christa E, Murphy, Philip, Nahon, Jean-Louis, Ngo, Tony, Norel, Xavier, Nyimanu, Duuamene, O'Carroll, Anne-Marie, Offermanns, Stefan, Panaro, Maria Antonietta, Parmentier, Marc, Pertwee, Roger G, Pin, Jean-Philippe, Prossnitz, Eric R, Quinn, Mark, Ramachandran, Rithwik, Ray, Manisha, Reinscheid, Rainer K, Rondard, Philippe, Rovati, G Enrico, Ruzza, Chiara, Sanger, Gareth J, Schöneberg, Torsten, Schulte, Gunnar, Schulz, Stefan, Segaloff, Deborah L, Serhan, Charles N, Stoddart, Leigh A, Sugimoto, Yukihiko, Summers, Roger, Tan, Valerie P, Thal, David, Thomas, Walter Wally, Timmermans, Pieter B M W M, Tirupula, Kalyan, Tulipano, Giovanni, Unal, Hamiyet, Unger, Thomas, Valant, Celine, Vanderheyden, Patrick, Vaudry, David, Vaudry, Hubert, Vilardaga, Jean-Pierre, Walker, Christopher S, Wang, Ji Ming, Ward, Donald T, Wester, Hans-Jürgen, Willars, Gary B, Woodruff, Trent M, Yao, Chengcan, and Ye, Richard D
- Abstract
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15538. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
- Published
- 2021
9. Experimentally induced gestational androgen excess disrupts glucoregulation in rhesus monkey dams and their female offspring
- Author
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Abbott, David H., Bruns, Cristin R., Barnett, Deborah K., Dunaif, Andrea, Goodfriend, Theodore L., Dumesic, Daniel A., and Tarantal, Alice F.
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Androgens -- Physiological aspects ,Androgens -- Genetic aspects ,Androgens -- Research ,Glucose metabolism -- Physiological aspects ,Glucose metabolism -- Genetic aspects ,Glucose metabolism -- Research ,Stein-Leventhal syndrome -- Risk factors ,Stein-Leventhal syndrome -- Genetic aspects ,Stein-Leventhal syndrome -- Research ,Biological sciences - Abstract
Discrete fetal androgen excess during early gestation in rhesus monkeys (Macaca mulatta) promotes endocrine antecedents of adult polycystic ovary syndrome (PCOS)-like traits in female offspring. Because developmental changes promoting such PCOS-like metabolic dysfunction remain unclear, the present study examined time-mated, gravid rhesus monkeys with female fetuses, of which nine gravid females received 15 mg of testosterone propionate (TP) subcutaneously daily from 40 to 80 days (first to second trimesters) of gestation [term, mean (range): 165 (155-175) days], whereas an additional six such females received oil vehicle injections over the same time interval. During gestation, ultrasonography quantified fetal growth measures and was used as an adjunct for fetal blood collections. At term, all fetuses were delivered by cesarean section for postnatal studies. Blood samples were collected from dams and infants for glucose, insulin, and total free fatty acid (FFA) determinations. TP injections transiently accelerated maternal weight gain in dams, very modestly increased head diameter of prenatally androgenized (PA) fetuses, and modestly increased weight gain in infancy compared with concurrent controls. Mild to moderate glucose intolerance, with increased area-under-the-curve circulating insulin values, occurred in TP-injected dams during an intravenous glucose tolerance test in the early second trimester. Moreover, reduced circulating FFA levels occurred in PA fetuses during a third trimester intravenous glucagon-tolbutamide challenge (140 days gestation), whereas excessive insulin sensitivity and increased insulin secretion relative to insulin sensitivity occurred in PA infants during an intravenous glucose-tolbutamide test at ~1.5 mo postnatal age. Data from these studies suggest that experimentally induced fetal androgen excess may result in transient hyperglycemic episodes in the intrauterine environment that are sufficient to induce relative increases in pancreatic function in PA infants, suggesting in this nonhuman primate model that differential programming of insulin action and secretion may precede adult metabolic dysfunction. fetal programming; polycystic ovary syndrome; hyperglycemic pregnancy; metabolic syndrome doi: 10.1152/ajpendo.00058.2010.
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- 2010
10. Obesity, sleep apnea, aldosterone, and hypertension
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Goodfriend, Theodore L.
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- 2008
- Full Text
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11. THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors
- Author
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Alexander, Stephen PH, Christopoulos, Arthur, Davenport, Anthony P, Kelly, Eamonn, Mathie, Alistair, Peters, John A, Veale, Emma L, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Sharman, Joanna L, Southan, Christopher, Davies, Jamie A, Arumugam, Thiruma V, Bennett, Andrew, Sjogren, Benita, Sobey, Christopher, Wong, Szu Shen, Abbracchio, Maria P, Alexander, Wayne, Al-hosaini, Khaled, Back, Magnus, Beaulieu, Jean-Martin, Bernstein, Kenneth E, Bettler, Bernhard, Birdsall, Nigel JM, Blaho, Victoria, Bousquet, Corinne, Brauner-Osborne, Hans, Burnstock, Geoffrey, Calo, Girolamo, Castano, Justo P, Catt, Kevin J, Ceruti, Stefania, Chazot, Paul, Chiang, Nan, Chun, Jerold, Cianciulli, Antonia, Clapp, Lucie H, Couture, Rejean, Csaba, Zsolt, Dent, Gordon, Singh, Khuraijam Dhanachandra, Douglas, Steven D, Dournaud, Pascal, Eguchi, Satoru, Escher, Emanuel, Filardo, Edward, Fong, Tung M, Fumagalli, Marta, Gainetdinov, Raul R, de Gasparo, Marc, Gershengorn, Marvin, Gobeil, Fernand, Goodfriend, Theodore L, Goudet, Cyril, Gregory, Karen J, Gundlach, Andrew L, Hamann, Jorg, Hanson, Julien, Hauger, Richard L, Hay, Debbie, Heinemann, Akos, Hollenberg, Morley D, Holliday, Nicholas D, Horiuchi, Mastgugu, Hoyer, Daniel, Hunyady, Laszlo, Husain, Ahsan, Ijzerman, Adriaan P, Inagami, Tadashi, Jacobson, Kenneth A, Jensen, Robert T, Jockers, Ralf, Jonnalagadda, Deepa, Karnik, Sadashiva, Kaupmann, Klemens, Kemp, Jacqueline, Kennedy, Charles, Kihara, Yasuyuki, Kozielewicz, Pawel, Kreienkamp, Hans-Juergen, Kukkonen, Jyrki P, Langenhan, Tobias, Leach, Katie, Lecca, Davide, Lee, John D, Leeman, Susan E, Leprince, Jerome, Lolait, Stephen J, Lupp, Amelie, Macrae, Robyn, Maguire, Janet, Mazella, Jean, McArdle, Craig A, Melmed, Shlomo, Michel, Martin C, Miller, Laurence, Mitolo, Vincenzo, Mouillac, Bernard, Murphy, Philip M, Nahon, Jean-Louis, Norel, Xavier, Nyimanu, Duuamene, O'Carroll, Anne-Marie, Offermanns, Stefan, Panaro, Maria A, Pertwee, Roger G, Pin, Jean-Philippe, Prossnitz, Eric, Ramachandran, Rithwik, Reinscheid, Rainer K, Rondard, Philippe, Rovati, G Enrico, Ruzza, Chiara, Sanger, Gareth, Schoeneberg, Torsten, Schulte, Gunnar, Schulz, Stefan, Segaloff, Deborah L, Serhan, Charles N, Stoddart, Leigh A, Sugimoto, Yukihiko, Summers, Roger, Tan, Valerie, Thomas, Walter, Timmermans, Pieter BMWM, Tirupula, Kalyan, Tulipano, Giovanni, Unal, Hamiyet, Unger, Thomas, Vanderheyden, Patrick, Vaudry, David, Vaudry, Hubert, Vilardaga, Jean-Pierre, Walker, Christopher S, Ward, Donald T, Wester, Hans-Juergen, Willars, Gary B, Williams, Tom Lloyd, Woodruff, Trent M, Yao, Chengcan, Aldrich, Richard W, Becirovic, Elvir, Biel, Martin, Catterall, William A, Conner, Alex C, Davies, Paul, Delling, Markus, Di Virgilio, Francesco, Falzoni, Simonetta, George, Chandy, Goldstein, Steve AN, Grissmer, Stephan, Ha, Kotdaji, Hammelmann, Verena, Hanukoglu, Israel, Jarvis, Mike, Jensen, Anders A, Kaczmarek, Leonard K, Kellenberger, Stephan, King, Brian, Lynch, Joseph W, Perez-Reyes, Edward, Plant, Leigh D, Rash, Lachlan D, Ren, Dejian, Sivilotti, Lucia G, Smart, Trevor G, Snutch, Terrance P, Tian, Jinbin, Van den Eynde, Charlotte, Vriens, Joris, Wei, Aguan D, Winn, Brenda T, Wulff, Heike, Xu, Haoxing, Yue, Lixia, Zhang, Xiaoli, Zhu, Michael, Coons, Laurel, Fuller, Peter, Korach, Kenneth S, Young, Morag, Bryant, Clare, Farndale, Richard W, Hobbs, Adrian, Jarvis, Gavin E, MacEwan, David, Monie, Tom P, Waldman, Scott, Beuve, Annie, Boison, Detlev, Brouckaert, Peter, Burnett, John C, Burns, Kathryn, Dessauer, Carmen, Friebe, Andreas, Garthwaite, John, Gertsch, Jurg, Helsby, Nuala, Izzo, Angelo A, Koesling, Doris, Kuhn, Michaela, Ostrom, Rennolds, Papapetropoulos, Andreas, Potter, Lincoln R, Pyne, Nigel J, Pyne, Susan, Russwurm, Michael, Schmidt, Harald HHW, Seifert, Roland, Stasch, Johannes-Peter, Szabo, Csaba, van der Stelt, Mario, van der Vliet, Albert, Watts, Val, Anderson, Catriona MH, Broer, Stefan, Dawson, Paul, Hagenbuch, Bruno, Hammond, James R, Hancox, Jules, Inui, Ken-ichi, Kanai, Yoshikatsu, Kemp, Stephan, Thwaites, David T, Verri, Tiziano, University of Nottingham, UK (UON), Monash university, University of Cambridge [UK] (CAM), University of Bristol [Bristol], University of Greenwich, Ninewells Hospital and Medical School [Dundee], University of Edinburgh, Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de médecine moléculaire de Rangueil (I2MR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR150-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Drug Design and Pharmacology [Copenhagen] (ILF), Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), University of Córdoba [Córdoba], Neuroprotection du Cerveau en Développement / Promoting Research Oriented Towards Early Cns Therapies (PROTECT), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Novartis Institutes for BioMedical Research (NIBR), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de pharmacologie moléculaire et cellulaire (IPMC), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), ARVALIS - Institut du végétal [Paris], Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Max Planck Institute for Heart and Lung Research (MPI-HLR), Max-Planck-Gesellschaft, Glaxo Smith Kline [Harlow], University of Antwerp (UA), Neuroendocrinologie cellulaire et moléculaire, European Synchrotron Radiation Facility (ESRF), Experimental Medicine and Immunotherapeutics [Cambridge, UK], Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University [Riyadh] (KSU), Department of Cardiology, Karolinska University Hospital, Karolinska Institutet [Stockholm], Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Department of Medical Sciences, Università degli Studi di Ferrara (UniFE), Department of Pharmacological Sciences and Biomolecular, University of Milan, Department of Molecular Biology Helen L. Dorris, The Scripps Research Institute, Département de Physiologie, Université de Montréal (UdeM), Department of Pharmacology, Université de Sherbrooke (UdeS), Departments of Physiology & Pharmacology, and Medicine [Calgary, Canada] (School of Medicine), University of Calgary, Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute of Biochemistry, Medical Faculty, University of Leipzig, Department of Molecular and Biochemical Pharmacology, and Pleinlaan 2
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0301 basic medicine ,RM ,Databases, Pharmaceutical ,Computer science ,Drug classification ,Pharmacology ,Ligands ,Receptors, G-Protein-Coupled ,NO ,law.invention ,03 medical and health sciences ,Databases ,G-Protein-Coupled ,0302 clinical medicine ,law ,Summary information ,Receptors ,Animals ,Humans ,Pharmacology & Pharmacy ,The Concise Guide to Pharmacology 2019/20 ,ComputingMilieux_MISCELLANEOUS ,G protein-coupled receptor ,Clinical pharmacology ,Science & Technology ,Extramural ,POTENT ,Pharmaceutical Preparations ,3. Good health ,030104 developmental biology ,Pharmaceutical ,[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Catalytic receptors ,Life Sciences & Biomedicine ,030217 neurology & neurosurgery - Abstract
© 2019 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society. The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.14748. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2019, and supersedes data presented in the 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
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- 2019
12. Pioglitazone improves insulin action and normalizes menstrual cycles in a majority of prenatally androgenized female rhesus monkeys
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Zhou, Rao, Bruns, Cristin M., Bird, Ian M., Kemnitz, Joseph W., Goodfriend, Theodore L., Dumesic, Daniel A., and Abbott, David H.
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- 2007
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13. An oxidized metabolite of linoleic acid increases intracellular calcium in rat adrenal glomerulosa cells
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Payet, Marcel D., Goodfriend, Theodore L., Bilodeau, Lyne, Mackendale, Cherilu, Chouinard, Lucie, and Gallo-Payet, Nicole
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Calcium ions -- Research ,Kidney glomerulus -- Research ,Linoleic acids -- Research ,Biological sciences - Abstract
EKODE, an epoxy-keto derivative of linoleic acid, was previously shown to stimulate aldosterone secretion in rat adrenal glomemlosa cells (15). In the present study, we investigated the effect of exogenous EKODE on cytosolic [[Ca.sup.2+]] increase and aimed to elucidate the mechanism involved in this process. Through the use of the fluorescent [Ca.sup.2+]-sensitive dye Fluo-4, EKODE was shown to rapidly increase intracellular [[Ca.sup.2+]] ([[[Ca.sup.2+]].sup.i] along a bell-shaped dose-response relationship with a maximum peak at 5 [micro]M. Experiments performed in the presence or absence of [Ca.sup.2+] revealed that this increase in [[[Ca.sup.2+]].sup.i] originated exclusively from intracellular pools. EKODE-induced [[[Ca.sup.2+]].sup.i] increase was blunted by prior application of angiotensin II, Xestospongin C, and cyclopiazonic acid, indicating that inositol trisphosphate ([InsP.sub.3])-sensitive [Ca.sup.2+] stores can be mobilized by EKODE despite the absence of [InsP.sub.3] production. Accordingly, EKODE response was not sensitive to the phospholipase C inhibitor U-73122. EKODE mobilized a [Ca.sup.2+] store included in the thapsigargin (TG)-sensitive stores, although the interaction between EKODE and TG appears complex, since EKODE added at the plateau response of TG induced a rapid drop in [[[Ca.sup.2+]].sub.i]. 9-Oxo-octadecadienoic acid, another oxidized derivative of linoleic acid, also increases [[[Ca.sup.2+]].sub.i], with a dose-response curve similar to EKODE. However, arachidonic and linoleic acids at 10 [micro]M failed to increase [[[Ca.sup.2+]].sub.1] but did reduce the amplitude of the response to EKODE. It is concluded that EKODE mobilizes [Ca.sup.2+] from an [InsP.sub.3]-sensitive store and that this [[[Ca.sup.2+]].sub.i] increase is responsible for aldosterone secretion by glomemlosa cells. Similar bell-shaped dose-response curves for aldosterone and [[[Ca.sup.2+]].sub.i] increases reinforce this hypothesis. intracellular calcium ion concentration
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- 2006
14. An oxidized metabolite of linoleic acid stimulates corticosterone production by rat adrenal cells
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Bruder, Eric D., Ball, Dennis L., Goodfriend, Theodore L., and Raff, Hershel
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Human physiology -- Research ,Linoleic acids -- Physiological aspects ,Biological sciences - Abstract
Oxidized derivatives of linoleic acid have the potential to alter steroidogenesis. One such derivative is 12, 13-epoxy-9-keto-10-(trans)-octadecenoic acid (EKODE). To evaluate the effect of EKODE on corticosterone production, dispersed rat zona fasciculata/reticularis (subcapsular) cells were incubated for 2 h with EKODE alone or together with rat ACTH (0, 0.2, or 2.0 ng/ml). In the absence of ACTH, EKODE (26 [micro]M) increased corticosterone production from 5.3 [+ or -] 2.3 to 14.7 [+ or -] 5.0 ng*[10.sup.6] cells*[h.sup.-1]. The stimulatory effect of ACTH was increased threefold in the presence of EKODE (26.0 [micro]M). Cholesterol transport/P-450scc activity was assessed by measuring basal and cAMP-stimulated pregnenolone production in the presence of cyanoketone (1.1 [micro]M). EKODE (13.1 and 26.0 [micro]M) significantly increased basal and cAMP-stimulated (0.1 mM) pregnenolone production. In contrast, EKODE decreased the effect of 1.0 mM cAMP. EKODE had no effect on early or late-pathway activity in isolated mitochondria. We conclude that EKODE stimulates corticosterone biosynthesis and amplifies the effect of ACTH. Increased levels of fatty acid metabolites may be involved in the increased glucocorticoid production observed in obese humans. steroidogenesis; glucocorticoid; fatty acid; zona fasciculata; epoxide
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- 2003
15. Nonesterified fatty acids in blood pressure control and cardiovascular complications
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Egan, Brent M., Greene, Eddie L., and Goodfriend, Theodore L.
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- 2001
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16. Contributors
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Becker, Bryan N., primary, Becker, Yolanda T., additional, Blichfeldt, Tracy C., additional, Boehm, Frederick J., additional, Brazy, Peter C., additional, Djamali, Arjang, additional, Goodfriend, Theodore L., additional, Herrick, Claire Elliott, additional, Jaffery, Jonathan B., additional, Kellerman, Paul S., additional, Kipp, Ryan, additional, Lindsey, Joshua David, additional, Lyerly, Kristin M., additional, Moorthy, A. Vishnu, additional, Oberley, Terry D., additional, Ozer, Byram H., additional, Samaniego, Milagros D., additional, Traeger, Kelly Ann, additional, Wen, Sung-Feng, additional, and Zhong, Weixiong, additional
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- 2009
- Full Text
- View/download PDF
17. Essential Hypertension
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Goodfriend, Theodore L., primary and Lyerly, Kristin M., additional
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- 2009
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18. Effect of exposure to hypoxia from birth on aldosterone in rabbits: role of unesterified fatty acids
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Raff, Hershel, Jankowski, Barbara M., Goodfriend, Theodore L., Baker, John E., and Papanek, Paula E.
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Hypoxia -- Physiological aspects ,Unsaturated fatty acids -- Physiological aspects ,Aldosterone -- Synthesis ,Biological sciences - Abstract
The mechanisms of aldosterogenesis in rabbits exposed to normobaric hypoxia were analyzed to determine the role of unesterified fatty acids in the progression of hypoxia-mediated inhibition of aldosterone synthesis. Analysis of adrenal capsular cells isolated from rabbits subjected to prolonged hypoxia indicated the presence of reduced basal and adenosine 3',5'-cyclic monophosphate-stimulated aldosterogenesis. Hypoxia also increased the levels of plasma unesterified fatty acids which mediated inhibition of aldosterone synthesis.
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- 1997
19. Angiotensin receptors and their antagonists
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Goodfriend, Theodore L., Elliott, Mary E., and Catt, Kevin J.
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Angiotensin -- Receptors ,Hypertension -- Drug therapy ,Heart failure -- Drug therapy - Abstract
Angiotensin receptor blockers are a new class of drug that may prove as beneficial as ACE inhibitors. Angiotensin receptor blockers prevent angiotensin II from binding to its receptor. Angiotensin II receptors are located in many organs such as blood vessels, heart, kidneys and brain. Angiotensin receptor blockers appear to be as effective in reducing high blood pressure as ACE inhibitors and without the side effects typical of ACE inhibitors, such as cough and angioedema. They are also effective in the treatment of heart failure.
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- 1996
20. Fatty acids enhance neurovascular reflex responses by effects on alpha(sub 1)-adrenoceptors
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Stepniakowski, Konrad T., Sallee, F. Randy, Goodfriend, Theodore L., Zhang, Zhen, and Egan, Brent M.
- Subjects
Fatty acids -- Research ,Obesity -- Research ,Heparin -- Observations ,Biological sciences - Abstract
Nonesterified fatty acids (NEFA) raise reflex vasoconstrictor responses through local effects on the vascular alpha(sub 1)-adrenoceptor, indicating that fatty acids may cause increased neurovascular tone in obese hypertensive patients. Intralipid-heparin increases the magnitude and duration of the venoconstrictor response to thigh cuff inflation and to locally infused phenylephrine. Dorsal hand venoconstrictor responses to thigh cuff inflation are quantified during intralipid-heparin coinfusion to analyze the effects of NEFAs on vascular responses to endogenous norepinephrine.
- Published
- 1996
21. Androgen Modulation of Adrenal Angiotensin Receptors
- Author
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Carroll, John E. and Goodfriend, Theodore L.
- Published
- 1984
22. Antibodies to Bradykinin and Angiotensin: A Use of Carbodiimides in Immunology
- Author
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Goodfriend, Theodore L., Levine, Lawrence, and Fasman, Gerald D.
- Published
- 1964
23. Possible Interactions Among Fatty Acids, Other Lipids, and Aldosterone in the Hypertension of Obesity
- Author
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Goodfriend, Theodore L, primary
- Published
- 1998
- Full Text
- View/download PDF
24. Acute Hyperlipidemia Increases Oxidative Stress More in African Americans Than in White Americans
- Author
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Lopes, Heno F, Morrow, Jason D, Stoijiljkovic, Milos P, Goodfriend, Theodore L, and Egan, Brent M
- Published
- 2003
- Full Text
- View/download PDF
25. Docosahexaenoic Acid is an Antihypertensive Nutrient That Affects Aldosterone Production in SHR (44381)
- Author
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Engler, Marguerite M., Engler, Mary B., Goodfriend, Theodore L., Ball, Dennis L., Yu, Zhigang, Su, Ping, and Kroetz, Deanna L.
- Published
- 1999
26. Angiotensin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
- Author
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Alexander, Wayne, primary, Bernstein, Kenneth E., primary, Catt, Kevin J., primary, De Gasparo, Marc, primary, Dhanachandra Singh, Khuraijam, primary, Eguchi, Satoru, primary, Escher, Emanuel, primary, Goodfriend, Theodore L., primary, Horiuchi, Mastgugu, primary, Hunyady, László, primary, Husain, Ahsan, primary, Inagami, Tadashi, primary, Karnik, Sadashiva, primary, Kemp, Jacqueline, primary, Thomas, Walter G., primary, Timmermans, Pieter B. M. W. M., primary, Tirupula, Kalyan, primary, Unal, Hamiyet, primary, Unger, Thomas, primary, and Vanderheyden, Patrick, primary
- Published
- 2019
- Full Text
- View/download PDF
27. Effects of Dietary γ-Linolenic Acid on Blood Pressure and Adrenal Angiotensin Receptors in Hypertensive Rats (44292)
- Author
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Engler, Marguerite M., Schambelan, Morris, Engler, Mary B., Ball, Dennis L., and Goodfriend, Theodore L.
- Published
- 1998
28. Drug Therapy: Angiotensin Receptors and Their Antagonists
- Author
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Goodfriend, Theodore L., Elliott, Mary E., and Catt, Kevin J.
- Published
- 1996
29. The pressor response to acute hyperlipidemia is enhanced in lean normotensive offspring of hypertensive parents
- Author
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Lopes, Heno F, Stojiljkovic, Milos P, Zhang, Da, Goodfriend, Theodore L, and Egan, Brent M
- Published
- 2001
- Full Text
- View/download PDF
30. Effect of omega-3 fatty acids on the vascular response to angiotensin in normotensive men
- Author
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Kenny, Dermot, Warltier, David C., Pleuss, Joan A., Hoffmann, Raymond G., Goodfriend, Theodore L., and Egan, Brent M.
- Subjects
Fish oils -- Health aspects ,Omega-3 fatty acids -- Health aspects ,Hypertension -- Care and treatment ,Angiotensin -- Physiological aspects ,Health - Abstract
There is a widespread interest in fish oil as a dietary supplement and possible nonpharmacologic adjunct in the treatment of hypertension. The effect of dietary fish oil on blood pressure is controversial and the effect on systemic hemodynamics and regional vascular reactivity in humans is unknown. To address these questions, a doubleblind, placebo-controlled, crossover study on the effect of dietary fish oil substitution was performed during a carefully controlled diet in 8 normotensive men. Systemic hemodynamics and the forearm vascular response to intrabrachial artery infusions of norepinephrine, phentolamine and angiotensin II were obtained. Compared with a safflower oil placebo, dietary fish oil had no effect an cardiac output (6.42 [+ or -] 0.38 vs 6.87 [+ or -] 0.28 liters/min p = not significant) or 24-hour blood pressure (122/68 [+ or -] 3/3 vs 122/68 [+ or -] 3/2 mm Hg, p = not significant). The vascular response to norepinephrine and phentolamine was unchanged. Fish oil, however, significantly (p
- Published
- 1992
31. Biochemical Effects of Angiotensin
- Author
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Goodfriend, Theodore L., Fyhrquist, Frej, Allmann, David, Page, Irvine H., editor, and Bumpus, F. Merlin, editor
- Published
- 1974
- Full Text
- View/download PDF
32. Hemodynamic effects of lipids in humans
- Author
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STOJILJKOVIC, MILOS P., ZHANG, DA, LOPES, HENO F., LEE, CHRISTINE G., GOODFRIEND, THEODORE L., and EGAN, BRENT M.
- Subjects
Lipids -- Abnormalities ,Hypertension -- Causes of ,Hypertension -- Genetic aspects ,Biological sciences - Abstract
Evidence suggests lipid abnormalities may contribute to elevated blood pressure, increased vascular resistance, and reduced arterial compliance among insulin-resistant subjects. In a study of 11 normal volunteers undergoing 4-h-long infusions of Intralipid and heparin to raise plasma nonesterified fatty acids (NEFAs), we observed increases of blood pressure. In contrast, blood pressure did not change in these same volunteers during a 4-h infusion of saline and heparin. To better characterize the hemodynamic responses to Intralipid and heparin, another group of 21 individuals, including both lean and obese volunteers, was studied after 3 wk on a controlled diet with 180 mmol sodium/day. Two and four hours after starting the infusions, plasma NEFAs increased by 134 and 111% in those receiving Intralipid and heparin, P [is less than] 0.01, whereas plasma NEFAs did not change in the first group of normal volunteers who received saline and heparin. The hemodynamic changes in lean and obese subjects in the second study were similar, and the results were combined. The infusion of Intralipid and heparin induced a significant increase in systolic (13.5 [+ or -] 2.1 mmHg) and diastolic (8.0 [+ or -] 1.5 mmHg) blood pressure as well as heart rate (9.4 [+ or -] 1.4 beats/min). Small and large artery compliance decreased, and systemic vascular resistance rose. These data raise the possibility that lipid abnormalities associated with insulin resistance contribute to the elevated blood pressure and heart rate as well as the reduced vascular compliance observed in subjects with the cardiovascular risk factor cluster. hypertension; nonesterified fatty acids; blood pressure
- Published
- 2001
33. Neonatal hypoxic hyperlipidemia in the rat: effects on aldosterone and corticosterone synthesis in vitro
- Author
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RAFF, HERSHEL, BRUDER, ERIC D., JANKOWSKI, BARBARA M., and GOODFRIEND, THEODORE L.
- Subjects
Adrenal cortex -- Research ,Fatty acids -- Analysis ,Hyperlipidemia -- Analysis ,Cell research -- Analysis ,Biological sciences - Abstract
Raff, Hershel, Eric D. Bruder, Barbara M. Jankowski, and Theodore L. Goodfriend. Neonatal hypoxic hyperlipidemia in the rat: effects on aldosterone and corticosterone synthesis in vitro. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R663-R668, 2000.--Neonatal hypoxia increases aldosterone production and plasma lipids. Because fatty acids can inhibit aldosterone synthesis, we hypothesized that increases in plasma lipids restrain aldosteronogenesis in the hypoxic neonate. We exposed rats to 7 days of hypoxia from birth to 7 days of age (suckling) or from 28 to 35 days of age (weaned at day 21). Plasma was analyzed for lipid content, and steroidogenesis was studied in dispersed whale adrenal glands untreated and treated to wash away lipids. Hypoxia increased plasma cholesterol, triglycerides, and nonesterified fatty acids in the suckling neonatal rat only. Washing away lipids increased aldosterone production in cells from 7-day-old rats exposed to hypoxia, but not in cells from normoxic 7-day-old rats or from normoxic or hypoxic 35-day-old rats. Addition of oleic or linolenic acid to washed cells inhibited both aldosterone and corticosterone production, although cells from hypoxic 7-day-old rats were less sensitive. We conclude that hypoxia induces hyperlipidemia in the suckling neonate and that elevated nonesterified fatty acids inhibit aldosteronogenesis. adrenal cortex; steroidogenesis; fatty acids; cholesterol; triglycerides
- Published
- 2000
34. Renin and the Angiotensins
- Author
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FREEDLENDER, ARTHUR E., primary and GOODFRIEND, THEODORE L., additional
- Published
- 1978
- Full Text
- View/download PDF
35. BINDING OF ANGIOTENSINS BY PLASMA FACTORS FROM MENTALLY RETARDED PATIENTS, BY PHOSPHOLIPIDS FOUND IN NERVOUS TISSUE, AND BY CELLS OF THE RETINA
- Author
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Goodfriend, Theodore L., primary, Hell, Naomi S., additional, Sindel, Mary E., additional, and Ball, Dennis L., additional
- Published
- 1977
- Full Text
- View/download PDF
36. LIST OF PARTICIPANTS
- Author
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Aars, Harald, primary, Ackerly, John, additional, Andersson, Bengt, additional, Barker, Jeffery L., additional, Berti, Gustavo, additional, Blaine, Edward H., additional, Boadle-Biber, Margaret C., additional, Boaz, David P., additional, Blumberg, Alan, additional, Buckley, Joseph P., additional, Buggy, James, additional, Bumpus, F. Merlin, additional, Calaresu, Franco R., additional, Chang, Yi-Chi, additional, Changaris, David G., additional, Clarke, David E., additional, Clay, George A., additional, Claybaugh, John R., additional, Denning, George S., additional, Dickinson, C.J., additional, Deuben, Roger R., additional, Druilhet, Robert E., additional, Erdös, Ervin G., additional, Epstein, Alan N., additional, Elghozi, Jean-Luc, additional, Ferrario, Carlos M., additional, Finkielman, Samuel, additional, Fitzsimons, James, additional, Ganten, Detlev, additional, Gildenberg, Philip L., additional, Goldstein, David J., additional, Goodfriend, Theodore L., additional, Gutman, Yehuda, additional, Heath, Robert G., additional, Hertting, G., additional, Hoffman, William E., additional, Igic, Rajko P., additional, Jandhyala, Bhagavan S., additional, Johnson, Alan Kim, additional, Joy, Michael D., additional, Khairallah, Philip A., additional, Leach, Carolyn, additional, Lokhandwala, Mustafa, additional, Longenecker, Gesina L., additional, Malvin, Richard L., additional, McCubbin, James W., additional, Miller, Edward D., additional, Mogenson, Gordon J., additional, Mouw, David, additional, Nahmod, Victor E., additional, Palaic, D., additional, Perhach, James L., additional, Philippu, A., additional, Phillips, M. Ian, additional, Printz, Morton P., additional, Radzialowski, Frederick M., additional, Reid, Ian A., additional, Romanyshyn, William M., additional, Samuels, Alan I., additional, Severs, Walter B., additional, Simpson, John B., additional, Singh, Surendrajit, additional, Solomon, Thomas A., additional, Swanson, L.W., additional, Sweet, Charles S., additional, Trippodo, Nick C., additional, Vollmer, Regis, additional, Wagner, Lorin A., additional, and Zimmerman, Ben G., additional
- Published
- 1977
- Full Text
- View/download PDF
37. Bradykinin
- Author
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GOODFRIEND, THEODORE L., primary and ODYA, CHARLES E., additional
- Published
- 1978
- Full Text
- View/download PDF
38. Activation of the antioxidant response element by specific oxidized metabolites of linoleic acid
- Author
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Wang, Rui, primary, Kern, Jonathan T., additional, Goodfriend, Theodore L., additional, Ball, Dennis L., additional, and Luesch, Hendrik, additional
- Published
- 2009
- Full Text
- View/download PDF
39. Response to Unexpected Therapeutic Response to Spironolactone: A Prospective Debate on Aldosterone and Potassium Ion in Hypertension
- Author
-
Goodfriend, Theodore L., primary
- Published
- 2007
- Full Text
- View/download PDF
40. Treating Resistant Hypertension With a Neglected Old Drug
- Author
-
Goodfriend, Theodore L., primary
- Published
- 2007
- Full Text
- View/download PDF
41. Aldosterone—A Hormone of Cardiovascular Adaptation and Maladaptation
- Author
-
Goodfriend, Theodore L., primary
- Published
- 2006
- Full Text
- View/download PDF
42. Resistant Hypertension, Obesity, Sleep Apnea, and Aldosterone
- Author
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Goodfriend, Theodore L., primary and Calhoun, David A., additional
- Published
- 2004
- Full Text
- View/download PDF
43. Epoxy-Keto Derivative of Linoleic Acid Stimulates Aldosterone Secretion
- Author
-
Goodfriend, Theodore L., primary, Ball, Dennis L., additional, Egan, Brent M., additional, Campbell, William B., additional, and Nithipatikom, Kasem, additional
- Published
- 2004
- Full Text
- View/download PDF
44. DASH Diet Lowers Blood Pressure and Lipid-Induced Oxidative Stress in Obesity
- Author
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Lopes, Heno F., primary, Martin, Kelley L., additional, Nashar, Khaled, additional, Morrow, Jason D., additional, Goodfriend, Theodore L., additional, and Egan, Brent M., additional
- Published
- 2003
- Full Text
- View/download PDF
45. Increasing plasma fatty acids elevates F2-isoprostanes in humans: implications for the cardiovascular risk factor cluster
- Author
-
Stojiljkovic, Milos P., primary, Lopes, Heno F., additional, Zhang, Da, additional, Morrow, Jason D., additional, Goodfriend, Theodore L., additional, and Egan, Brent M., additional
- Published
- 2002
- Full Text
- View/download PDF
46. Moderate Sodium Restriction Enhances the Pressor Response to Hyperlipidemia in Obese, Hypertensive Patients
- Author
-
Lopes, Heno F., primary, Stojiljkovic, Milos P., additional, Zhang, Da, additional, Goodfriend, Theodore L., additional, and Egan, Brent M., additional
- Published
- 2002
- Full Text
- View/download PDF
47. Visceral Obesity and Insulin Resistance Are Associated with Plasma Aldosterone Levels in Women
- Author
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Goodfriend, Theodore L., primary, Kelley, David E., additional, Goodpaster, Bret H., additional, and Winters, Stephen J., additional
- Published
- 1999
- Full Text
- View/download PDF
48. Docosahexaenoic Acid is an Antihypertensive Nutrient That AffectsAldosterone Production in SHR
- Author
-
Engler, Marguerite M., primary, Engler, Mary B., additional, Goodfriend, Theodore L., additional, Ball, Dennis L., additional, Yu, Zhigang, additional, Su, Ping, additional, and Kroetz, Deanna L., additional
- Published
- 1999
- Full Text
- View/download PDF
49. Intralipid Enhances α 1 -Adrenergic Receptor–Mediated Pressor Sensitivity
- Author
-
Haastrup, Adetola T., primary, Stepniakowski, Konrad T., additional, Goodfriend, Theodore L., additional, and Egan, Brent M., additional
- Published
- 1998
- Full Text
- View/download PDF
50. Torsemide inhibits aldosterone secretion in vitro
- Author
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Goodfriend, Theodore L., primary, Ball, Dennis L., additional, Oelkers, Wolfgang, additional, and Bähr, Volker, additional
- Published
- 1998
- Full Text
- View/download PDF
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