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3. Viral Vector Based Immunotherapy for Peanut Allergy.

Author

Gonzalez-Visiedo, Miguel, Herzog, Roland W., Munoz-Melero, Maite, Blessinger, Sophia A., Cook-Mills, Joan M., Daniell, Henry, and Markusic, David M.

Subjects
*PEANUT allergy, *REGULATORY T cells, *FOOD allergy, *IMMUNOLOGICAL tolerance, *ADENO-associated virus, *TRANSGENE expression
Abstract

Food allergy (FA) is estimated to impact up to 10% of the population and is a growing health concern. FA results from a failure in the mucosal immune system to establish or maintain immunological tolerance to innocuous dietary antigens, IgE production, and the release of histamine and other mediators upon exposure to a food allergen. Of the different FAs, peanut allergy has the highest incidence of severe allergic responses, including systemic anaphylaxis. Despite the recent FDA approval of peanut oral immunotherapy and other investigational immunotherapies, a loss of protection following cessation of therapy can occur, suggesting that these therapies do not address the underlying immune response driving FA. Our lab has shown that liver-directed gene therapy with an adeno-associated virus (AAV) vector induces transgene product-specific regulatory T cells (Tregs), eradicates pre-existing pathogenic antibodies, and protects against anaphylaxis in several models, including ovalbumin induced FA. In an epicutaneous peanut allergy mouse model, the hepatic AAV co-expression of four peanut antigens Ara h1, Ara h2, Ara h3, and Ara h6 together or the single expression of Ara h3 prevented the development of a peanut allergy. Since FA patients show a reduction in Treg numbers and/or function, we believe our approach may address this unmet need. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Estudio de los mecanismos inmunológicos implicados en la inmunoterapia específica con alérgenos. Papel de las células T reguladoras y efectoras específicas

Author

Gonzalez Visiedo, Miguel, Mayorga Mayorga, Cristobalina, Torres-Jaen, Maria Josefa, Biología Celular, Genética y Fisiología, and Torres Jaén, María José

Subjects
Alérgenos, Ciencias - Tesis Doctorales, Inmunoterapia, Linfocitos T, Linfocitos B, Células T reguladoras
Abstract

Fecha de Lectura de Tesis: 29 Enero 2018. Dentro de las reacciones alérgicas originadas en las vías respiratorias, la rinitis alérgica (RA) es la que cobra mayor importancia en cuanto a su incidencia en la población. Entre los alérgenos más prevalentes en esta patología se encuentran los pólenes, epitelios animales hongos y ácaros del polvo doméstico, entre otros, siendo este último de gran interés en nuestra zona. El tratamiento de la RA va encaminado a tratar la inflamación alérgica subyacente, que debe ser controlada para prevenir su cronificación. Entre los diferentes métodos actuales, el tratamiento inmunomodulador pretende desviar el patrón de la respuesta efectora desde una reacción alérgica tipo Th2 hacia una respuesta tolerante tipo Th0/1 con la generación de células T reguladoras (Treg) con capacidad supresora de células T efectoras. Este tratamiento es el único que ha demostrado ser efectivo modificando la etiopatogenia de la enfermedad. Éstos son tratamientos largos y costosos que no siempre muestran una respuesta eficaz. Por ello, la identificación de biomarcadores de eficacia que determine la respuesta y el grado de protección es uno de los principales objetivos que proporcionaría una herramienta eficaz al clínico a la hora de tomar decisión respecto al tratamiento del paciente. Por otro lado, y a pesar del papel principal otorgado a las Treg en la inducción de una respuesta de tolerancia durante una IT, hoy en día se desconoce el mecanismo subyacente a través del cual este tipo celular ejerce su función, existiendo resultados contradictorios sobre el tema. Para responder a estas cuestiones, en esta tesis doctoral se ha determinado el perfil de reactividad de las diferentes subpoblaciones de linfocitos T y B en los pacientes respondedores y no respondedores a la IT frente al ácaro del polvo Dermatophagoides pteronissinus (DP).

Published
2018

5. Abstracts from the 11th Symposium on Experimental Rhinology and Immunology of the Nose (SERIN 2017)

Author

Gracia, Ibon Eguiluz, primary, Rondón, Carmen, additional, Campo, Paloma, additional, Prieto, Ana, additional, Mayorga, Lina, additional, Galindo, Luisa, additional, Molina, Ana, additional, Blanca, Miguel, additional, Torres, Maria Jose, additional, Morikawa, Taiyo, additional, Fukuoka, Ayumi, additional, Matsushita, Kazufumi, additional, Fujieda, Shigeharu, additional, Yoshimoto, Tomohiro, additional, Iwasaki, Naruhito, additional, Smulders, Tamar, additional, Van Egmond, Danielle, additional, Van Drunen, Kees, additional, Van Der Schee, Marc, additional, Beule, Achim Georg, additional, Berings, Margot, additional, Jult, Anton, additional, Vermeulen, Hanne, additional, De Ruyck, Natalie, additional, Derycke, Lara, additional, Ucar, Hakan, additional, Ghekiere, Philip, additional, Temmerman, Robin, additional, Ellis, John, additional, Bachert, Claus, additional, Lambrecht, Bart, additional, Dullaers, Melissa, additional, Gevaert, Philippe, additional, Arasi, Stefania, additional, Perna, Serena, additional, Resch, Yvonne, additional, Lupinek, Christian, additional, Chen, Kuan-Wei, additional, Vrtala, Susanne, additional, Valenta, Rudolf, additional, Matricardi, Paolo Maria, additional, Gonçalves, Ivânia, additional, Jacinto, Tiago, additional, Amaral, Rita, additional, Pereira, Ana M., additional, Araújo, Luís M., additional, Couto, Mariana, additional, Fonseca, João A., additional, Stjarne, Par, additional, Kaulsay, Ranbir, additional, Pohl, Wolfgang, additional, Plaza, Maria Carmen, additional, Prieto, Ana Maria, additional, Mayorga, Cristobalina, additional, Herknerova, Magdalena, additional, Wang, Tengchin, additional, Wu, Chiejun, additional, Kilimajer, Jonathan, additional, Pujols, Laura, additional, Roca-Ferrer, Jordi, additional, Callejas, Borja, additional, Fuentes-Prado, Mireya, additional, Perez-Gonzalez, Maria, additional, Alobid, Isam, additional, Valero, Antonio, additional, Picado, Cesar, additional, Murray, Ruth, additional, Mullol, Joaquim, additional, Steelant, Brecht, additional, Martens, Katleen, additional, Boeckxstaens, Guy, additional, Seys, Sven F., additional, Hellings, Peter W., additional, Biggs, Timothy C., additional, Hayes, Stephen M., additional, Harries, Philip G., additional, Pender, Sylvia, additional, Salib, Rami J., additional, Kim, Jean, additional, Lee, Hyun Sil, additional, Kalogjera, Livije, additional, Vrkic, Nada, additional, Topic, Anita, additional, Tomljenovic, Dejan, additional, Greguric, Tomislav, additional, Radovanovic, Patricija Bankovic, additional, Jund, Rainer, additional, Haimerl, Pascal, additional, Chaker, Adam M., additional, Schober, Yvonne, additional, Schindela, Sonja, additional, Nockher, Andreas, additional, Schmidt-Weber, Carsten B., additional, Bieren, Julia Esser-Von, additional, Ickrath, Pascal, additional, Kleinsasser, Norbert, additional, Beyersdorf, Niklas, additional, Ding, Xin, additional, Hagen, Rudolf, additional, Hackenberg, Stephan, additional, Cangiano, Daniela, additional, Cinetto, Francesco, additional, Brescia, Giuseppe, additional, Marioni, Gino, additional, Zanotti, Claudia, additional, Schiavon, Franco, additional, Padoan, Roberto, additional, Caputo, Ilaria, additional, Neri, Raffaella, additional, Agostini, Carlo, additional, Kim, Ji Heui, additional, Jang, Yong Ju, additional, Lim, Ji Youn, additional, Kim, Sung Hee, additional, Savlevich, Elena, additional, Gaganov, Leonid, additional, Kochnova, Maria, additional, Egorov, Victor, additional, Fok, Jie Shen, additional, Hanif, Tanzeela, additional, Renkonen, Jutta, additional, Joenväärä, Sakari, additional, Kankainen, Matti, additional, Mäkelä, Mika, additional, Kauppi, Paula, additional, Pelkonen, Anna, additional, Mattila, Pirkko, additional, Renkonen, Risto, additional, Toppila-Salmi, Sanna, additional, Holtappels, Gabriele, additional, Lambrecht, Bart N., additional, Blanca-López, Natalia, additional, Gonzalez-Visiedo, Miguel, additional, Jurado, Raquel, additional, and Canto, Gabriela, additional

Published
2017
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