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17 results on '"Gonzalez-Herrero, Ines"'

1. An intact gut microbiome protects genetically predisposed mice against leukemia

Author

Vicente-Dueñas, Carolina, Janssen, Stefan, Oldenburg, Marina, Auer, Franziska, González-Herrero, Inés, Casado-García, Ana, Isidro-Hernández, Marta, Raboso-Gallego, Javier, Westhoff, Philipp, Pandyra, Aleksandra A., Hein, Daniel, Gössling, Katharina L., Alonso-López, Diego, De Las Rivas, Javier, Bhatia, Sanil, García-Criado, Francisco Javier, García-Cenador, María Begoña, Weber, Andreas P.M., Köhrer, Karl, Hauer, Julia, Fischer, Ute, Sánchez-García, Isidro, and Borkhardt, Arndt

Published
2020
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2. Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice

Author

García-Ramírez, Idoia, Tadros, Saber, González-Herrero, Inés, Martín-Lorenzo, Alberto, Rodríguez-Hernández, Guillermo, Moore, Dalia, Ruiz-Roca, Lucía, Blanco, Oscar, Alonso-López, Diego, Rivas, Javier De Las, Hartert, Keenan, Duval, Romain, Klinkebiel, David, Bast, Martin, Vose, Julie, Lunning, Matthew, Fu, Kai, Greiner, Timothy, Rodrigues-Lima, Fernando, Jiménez, Rafael, Criado, Francisco Javier García, Cenador, María Begoña García, Brindle, Paul, Vicente-Dueñas, Carolina, Alizadeh, Ash, Sánchez-García, Isidro, and Green, Michael R.

Published
2017
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3. Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice

Author

Vicente-Dueñas, Carolina, Fontán, Lorena, Gonzalez-Herrero, Ines, Romero-Camarero, Isabel, Segura, Victor, Aznar, M. Angela, Alonso-Escudero, Esther, Campos-Sanchez, Elena, Ruiz-Roca, Lucía, Barajas-Diego, Marcos, Sagardoy, Ainara, Martinez-Ferrandis, Jose I., Abollo-Jimenez, Fernando, Bertolo, Cristina, Peñuelas, Ivan, Garcia-Criado, Francisco J., García-Cenador, María B., Tousseyn, Thomas, Agirre, Xabier, Prosper, Felipe, Garcia-Bragado, Federico, McPhail, Ellen D., Lossos, Izidore S., Du, Ming-Qing, Flores, Teresa, Hernandez-Rivas, Jesus M., Gonzalez, Marcos, Salar, Antonio, Bellosillo, Beatriz, Conde, Eulogio, Siebert, Reiner, Sagaert, Xavier, Cobaleda, Cesar, Sanchez-Garcia, Isidro, and Martinez-Climent, Jose A.

Published
2012

5. Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID

Author

Rodriguez-Hernandez, Guillermo, Opitz, Friederike V., Delgado, Pilar, Walter, Carolin, Alvarez-Prado, Angel F., Gonzalez-Herrero, Ines, Auer, Franziska, Fischer, Ute, Janssen, Stefan, Bartenhagen, Christoph, Raboso-Gallego, Javier, Casado-Garcia, Ana, Orfao, Alberto, Blanco, Oscar, Alonso-Lopez, Diego, De Las Rivas, Javier, Gonzalez de Tena-Davila, Sara, Muschen, Markus, Dugas, Martin, Garcia Criado, Francisco Javier, Garcia Cenador, Maria Begona, Vicente-Duenas, Carolina, Hauer, Julia, Ramiro, Almudena R., Sanchez-Garcia, Isidro, Borkhardt, Arndt, Rodriguez-Hernandez, Guillermo, Opitz, Friederike V., Delgado, Pilar, Walter, Carolin, Alvarez-Prado, Angel F., Gonzalez-Herrero, Ines, Auer, Franziska, Fischer, Ute, Janssen, Stefan, Bartenhagen, Christoph, Raboso-Gallego, Javier, Casado-Garcia, Ana, Orfao, Alberto, Blanco, Oscar, Alonso-Lopez, Diego, De Las Rivas, Javier, Gonzalez de Tena-Davila, Sara, Muschen, Markus, Dugas, Martin, Garcia Criado, Francisco Javier, Garcia Cenador, Maria Begona, Vicente-Duenas, Carolina, Hauer, Julia, Ramiro, Almudena R., Sanchez-Garcia, Isidro, and Borkhardt, Arndt

Abstract

The prerequisite to prevent childhood B-cell acute lymphoblastic leukemia (B-ALL) is to decipher its etiology. The current model suggests that infection triggers B-ALL development through induction of activation-induced cytidine deaminase (AID; also known as AICDA) in precursor B-cells. This evidence has been largely acquired through the use of ex vivo functional studies. However, whether this mechanism governs native non-transplant B-ALL development is unknown. Here we show that, surprisingly, AID genetic deletion does not affect B-ALL development in Pax5-haploinsufficient mice prone to B-ALL upon natural infection exposure. We next test the effect of premature AID expression from earliest pro-B-cell stages in B-cell transformation. The generation of AID off-target mutagenic activity in precursor B-cells does not promote B-ALL. Likewise, known drivers of human B-ALL are not preferentially targeted by AID. Overall these results suggest that infections promote B-ALL through AID-independent mechanisms, providing evidence for a new model of childhood B-ALL development.

Published
2019

7. CREBBP Loss Cooperates with BCL2 Over-Expression to Promote Lymphoma in Mice

Author

Idoia, García-Ramírez, primary, Shrishrimal, Shashank, additional, Gonzalez-Herrero, Ines, additional, Martín-Lorenzo, Alberto, additional, rodriguez-Hernandez, Guillermo, additional, Duval, Romain, additional, Moore, Dalia, additional, Ruiz-Roca, Lucia, additional, Blanco, Oscar, additional, Alonso-Lopez, Diego, additional, de Las Rivas, Javier, additional, Klinkibiel, David, additional, Bast, Martin, additional, Greiner, Timothy C., additional, Vose, Julie M, additional, Lunning, Matthew, additional, Rodrigues-Lima, Fernando, additional, Jiménez, Rafael, additional, Garcia-criado, Francisco, additional, garcia Cenador, Maria, additional, Brindle, Paul, additional, vicente-Duenas, Carolina, additional, Sánchez-García, Isidro, additional, and Green, Michael R, additional

Published
2016
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9. A New ETV6-RUNX1 In Vivo Model Produces a Phenocopy of the Human Pb-ALL

Author

rodriguez-Hernandez, Guillermo, primary, Hauer, Julia, additional, Martín-Lorenzo, Alberto, additional, Schaefer, Daniel, additional, Bartenhagen, Christoph, additional, Garcia-Ramirez, Idoia, additional, Auer, Franziska, additional, Gonzalez-Herrero, Ines, additional, Ruiz-Roca, Lucia, additional, Okpanyi, Vera, additional, Fischer, Ute, additional, Dugas, Martin, additional, Bhatia, Sanil, additional, Gombert, Michael, additional, Krell, Pina, additional, Chen, Cai, additional, Garcia Suquia, Marta, additional, Rascon Trincado, Maria, additional, Garcia Sanchez, Angel, additional, Blanco, Oscar, additional, garcia Cenador, Maria, additional, Garcia-criado, Francisco, additional, Cobaleda, Cesar, additional, Alonso-Lopez, Diego, additional, de Las Rivas, Javier, additional, vicente-Duenas, Carolina, additional, Sanchez-Gracia, Isidro, additional, and Borkhardt, Arndt, additional

Published
2015
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10. Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation

Author

Romero-Camarero, Isabel, primary, Jiang, Xiaoyu, additional, Natkunam, Yasodha, additional, Lu, Xiaoqing, additional, Vicente-Dueñas, Carolina, additional, Gonzalez-Herrero, Ines, additional, Flores, Teresa, additional, Luis Garcia, Juan, additional, McNamara, George, additional, Kunder, Christian, additional, Zhao, Shuchun, additional, Segura, Victor, additional, Fontan, Lorena, additional, Martínez-Climent, Jose A., additional, Javier García-Criado, Francisco, additional, Theis, Jason D., additional, Dogan, Ahmet, additional, Campos-Sánchez, Elena, additional, Green, Michael R., additional, Alizadeh, Ash A., additional, Cobaleda, Cesar, additional, Sánchez-García, Isidro, additional, and Lossos, Izidore S, additional

Published
2013
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12. HGAL-a Germinal Center Specific Protein, Enhances B-Cell Receptor Signaling by Activation of Syk, Leading to Follicular Lymphoproliferation

Author

Jiang, Xiaoyu, primary, Romero-Camarero, Isabel, additional, Lu, Xiaoqing, additional, Vicente-Dueñas, Carolina, additional, Gonzalez-Herrero, Ines, additional, Flores, Teresa, additional, Garcia, Juan Luis, additional, McNamara, George, additional, Kunder, Christian, additional, Natkunam, Yasodha, additional, Segura, Victor, additional, Fontan-Gabas, Lorenna, additional, Martinez-Climent, Jose A, additional, Alizadeh, Ash A, additional, Cobaleda, Cesar, additional, Sanchez-Garcia, Isidro, additional, and Lossos, Izidore S, additional

Published
2011
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15. TWIST1 Promotes Invasion Through Mesenchymal Change in Human Glioblastoma

Author

Mikheeva, Svetlana A, Mikheev, Andrei M, Petit, Audrey, Oxford, Robert G, Khorasani, Leila, Maxwell, John-Patrick, Glackin, Carlotta A, González-Herrero, Inés, Sánchez-García, Isidro, Silber, John R, Horner, Philip J, Rostomily, Robert C, Beyer, Richard, and Wakimoto, Hiroko

Abstract

Background: Tumor cell invasion into adjacent normal brain is a mesenchymal feature of GBM and a major factor contributing to their dismal outcomes. Therefore, better understandings of mechanisms that promote mesenchymal change in GBM are of great clinical importance to address invasion. We previously showed that the bHLH transcription factor TWIST1 which orchestrates carcinoma metastasis through an epithelial mesenchymal transition (EMT) is upregulated in GBM and promotes invasion of the SF767 GBM cell line in vitro. Results: To further define TWIST1 functions in GBM we tested the impact of TWIST1 over-expression on invasion in vivo and its impact on gene expression. We found that TWIST1 significantly increased SNB19 and T98G cell line invasion in orthotopic xenotransplants and increased expression of genes in functional categories associated with adhesion, extracellular matrix proteins, cell motility and locomotion, cell migration and actin cytoskeleton organization. Consistent with this TWIST1 reduced cell aggregation, promoted actin cytoskeletal re-organization and enhanced migration and adhesion to fibronectin substrates. Individual genes upregulated by TWIST1 known to promote EMT and/or GBM invasion included SNAI2, MMP2, HGF, FAP and FN1. Distinct from carcinoma EMT, TWIST1 did not generate an E- to N-cadherin "switch" in GBM cell lines. The clinical relevance of putative TWIST target genes SNAI2 and fibroblast activation protein alpha (FAP) identified in vitro was confirmed by their highly correlated expression with TWIST1 in 39 human tumors. The potential therapeutic importance of inhibiting TWIST1 was also shown through a decrease in cell invasion in vitro and growth of GBM stem cells. Conclusions: Together these studies demonstrated that TWIST1 enhances GBM invasion in concert with mesenchymal change not involving the canonical cadherin switch of carcinoma EMT. Given the recent recognition that mesenchymal change in GBMs is associated with increased malignancy, these findings support the potential therapeutic importance of strategies to subvert TWIST1-mediated mesenchymal change., Version of Record

Published
2010
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16. CREBBPLoss Cooperates with BCL2Over-Expression to Promote Lymphoma in Mice

Author

Idoia, García-Ramírez, Shrishrimal, Shashank, Gonzalez-Herrero, Ines, Martín-Lorenzo, Alberto, rodriguez-Hernandez, Guillermo, Duval, Romain, Moore, Dalia, Ruiz-Roca, Lucia, Blanco, Oscar, Alonso-Lopez, Diego, de Las Rivas, Javier, Klinkibiel, David, Bast, Martin, Greiner, Timothy C., Vose, Julie M, Lunning, Matthew, Rodrigues-Lima, Fernando, Jiménez, Rafael, Garcia-criado, Francisco, garcia Cenador, Maria, Brindle, Paul, vicente-Duenas, Carolina, Sánchez-García, Isidro, and Green, Michael R

Abstract

Follicular lymphoma (FL) is genetically characterized by translocations of the BCL2oncogene that are found in ~90% of patients, and mutations of chromatin modifying genes that are found in up to 96% of patients. The latter include inactivating mutations of KMT2Dand CREBBP, and activating mutations of EZH2, among others.

Published
2016
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17. A New ETV6-RUNX1In Vivo Model Produces a Phenocopy of the Human Pb-ALL

Author

rodriguez-Hernandez, Guillermo, Hauer, Julia, Martín-Lorenzo, Alberto, Schaefer, Daniel, Bartenhagen, Christoph, Garcia-Ramirez, Idoia, Auer, Franziska, Gonzalez-Herrero, Ines, Ruiz-Roca, Lucia, Okpanyi, Vera, Fischer, Ute, Dugas, Martin, Bhatia, Sanil, Gombert, Michael, Krell, Pina, Chen, Cai, Garcia Suquia, Marta, Rascon Trincado, Maria, Garcia Sanchez, Angel, Blanco, Oscar, garcia Cenador, Maria, Garcia-criado, Francisco, Cobaleda, Cesar, Alonso-Lopez, Diego, de Las Rivas, Javier, vicente-Duenas, Carolina, Sanchez-Gracia, Isidro, and Borkhardt, Arndt

Abstract

Introduction

Published
2015
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