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1. TENSSION: A Tool for the Medical Patient Follow-Up

Author

Ignacio, Del Rey, Gil, Ana Belén, González-Celador, R., Kacprzyk, Janusz, editor, Demazeau, Yves, editor, Dignum, Frank, editor, Corchado, Juan M., editor, Bajo, Javier, editor, Corchuelo, Rafael, editor, Corchado, Emilio, editor, Fernández-Riverola, Florentino, editor, Julián, Vicente J., editor, Pawlewski, Pawel, editor, and Campbell, Andrew, editor

Published
2010
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7. [Analysis of neutrophil gelatinase-associated lipocalin in the critical patient].

Author

Marti-Macia C, Tomasa TM, Sancho A, Galán A, Fernández-Llamazares J, Macias V, Roca J, Gonzalez-Celador R, Amestoy É, and Klamburg J

Subjects
APACHE, Acute Kidney Injury blood, Acute Kidney Injury urine, Adult, Aged, Biomarkers blood, Biomarkers urine, Creatinine blood, Diagnosis-Related Groups, Early Diagnosis, Female, Hospital Mortality, Humans, Intensive Care Units, Length of Stay statistics & numerical data, Lipocalin-2, Male, Middle Aged, Prognosis, Prospective Studies, Sensitivity and Specificity, Severity of Illness Index, Acute Kidney Injury diagnosis, Acute-Phase Proteins urine, Critical Illness, Lipocalins urine, Proto-Oncogene Proteins urine
Abstract

Objective: To determine if NGAL value exceeding 150 ng/mL is a good diagnostic test for acute renal failure in critically ill patients., Design: Prospective, observational cohort., Setting: Intensive Care Unit and Cardiac Surgery Intensive Care Service at Hospital Germans Trias I Pujol., Participants: Patients admitted to the Intensive Care department the Designated days in the studio., Interventions: Analysis of serum creatinine blood given from 7 days prior to the start of the study, and daily during 4 weeks and by determination of NGAL urine test in frozen sample, analyzer ARCHITECT (Abbott Diagnostics) determined by immunoassay the day baseline and 2 times a week for 4 weeks, analysis of the stay and mortality., Results: A total of 529 NGAL samples were obtained from 46 patients. 37% of patients had a value of NGAL>150 ng/mL. The Sensivity of the test to diagnose acute renal failure was 69%, Specifity was 75,7%. However, the Positive Predictive Test Value was 53%, which means that 47% of patients with high NGAL did not develop AKI. A NGAL >150 mg/dL was associated with a significantly higher SOFA and a longer stay in the ICU. The mortality of patients with elevated NGAL was 58.8%., Conclusions: A NGAL>150 ng/mL does not seem to be an excellent test for AKI in critically ill patients but is associated with a worse prognosis., (Copyright © 2012 Elsevier España, S.L. y SEMICYUC. All rights reserved.)

Published
2014
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