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3. Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study Protocol

Author

Crowley, James J, Cappi, Carolina, Ochoa-Panaifo, Marcos E, Frederick, Renee M, Kook, Minjee, Wiese, Andrew D, Rancourt, Diana, Atkinson, Elizabeth G, Giusti-Rodriguez, Paola, Anderberg, Jacey L, Abramowitz, Jonathan S, Adorno, Victor R, Aguirre, Cinthia, Alves, Gustavo S, Alves, Gilberto S, Ancalade, NaEshia, Arellano Espinosa, Alejandro A, Arnold, Paul D, Ayton, Daphne M, Barbosa, Izabela G, Barón Castano, Laura Marcela, Barrera, Cynthia N, Belén Prieto, María, Berardo, María Celeste, Berrones, Dayan, Best, John R, Bigdeli, Tim B, Burton, Christie L, Callahan, Jennifer L, Carneiro, Maria Cecília B, Cepeda, Sandra L, Chazelle, Evelyn, Chire, Jessica M, Churruca Munoz, Macarena, Claisse Quiroz, Pamela, Cobite, Journa, Comer, Jonathan S, Costa, Daniel L, Crosbie, Jennifer, Cruz, Victor O, Dager, Guillermo, Daza, Luisa F, de la Rosa-Gómez, Anabel, del Río, Daniela, Delage, Fernanda Z, Dreher, Carolina B, Fay, Lucila, Fazio, Tomas, Ferrão, Ygor A, Ferreira, Gabriela M, Figueroa, Edith G, Fontenelle, Leonardo F, Forero, Diego A, Fragoso, Daniele TH, Gadad, Bharathi S, Garrison, Sheldon R, González, Andres, Gonzalez, Laura D, González, Marco A, Gonzalez-Barrios, Polaris, Goodman, Wayne, Guintivano, Jerry, Guttfreund, Daniel G, Guzick, Andrew G, Halvorsen, Matthew W, Hovey, Joseph D, Janssen-Aguilar, Reinhard, Jensen, Matias, Jimenez Reynolds, Alexandra Z, Juárez Lujambio, Joali Alexandra, Khalfe, Nasim, Knutsen, Madison A, Lack, Caleb, Lanzagorta, Nuria, Lima, Monicke O, Longhurst, Melanie O, Lozada Martinez, David A, Luna, Elba S, Marques, Andrea H, Martinez, Molly, Matos, Maria de Los Angeles, Maye, Caitlyn E, McGuire, Joseph F, Menezes, Gabriela, Minaya, Charlene, Miño, Tomás, Mithani, Sara M, Montes de Oca, Circe, Morales-Rivero, Alonso, Moreira-de-Oliveira, Maria E, Morris, Olivia J, Muñoz, Sandra I, Naqqash, Zainab, Núñez Bracho, Ambar A, Núñez Bracho, Belinda E, Ochoa Rojas, Maria Corina, Olavarria Castaman, Luis A, Ortega, Iliana, Patel, Darpan I, Patrick, Ainsley K, Paz y Mino, Mariel, Perales Orellana, Jose L, Perdigão Stumpf, Bárbara, Peregrina, Tamara, Pérez Duarte, Tania, Piacsek, Kelly L, Placencia, Maritza, Quarantini, Lucas C, Quarantini-Alvim, Yana, Ramos, Renato T, Ramos, Iaroslava C, Ramos, Vanessa R, Ramsey, Kesley A, Ray, Elise V, Richter, Margaret A, Riemann, Bradley C, Rivas, Juan C, Rosario, Maria C, Ruggero, Camilo J, Ruiz-Chow, Angel A, Ruiz-Velasco, Alejandra, Sampaio, Aline S, Saraiva, Leonardo C, Schachar, Russell J, Schneider, Sophie C, Schweissing, Ethan J, Seligman, Laura D, Shavitt, Roseli G, Soileau, Keaton J, Stewart, S. Evelyn, Storch, Shaina B, Strouphauer, Emily R, Timpano, Kiara R, Treviño-de la Garza, Beatriz, Vargas-Medrano, Javier, Vásquez, María I, Vidal Martinez, Guadalupe, Weinzimmer, Saira A, Yanez, Mauricio A, Zai, Gwyneth, Zapata-Restrepo, Lina M, Zappa, Luz M, Zepeda-Burgos, Raquel M, Zoghbi, Anthony W, Miguel, Euripedes C, Rodriguez, Carolyn I, Martinez Mallen, Mayra C, Moya, Pablo R, Borda, Tania, Moyano, María Beatriz, Mattheisen, Manuel, Pereira, Stacey, Lázaro-Muñoz, Gabriel, Martinez-Gonzalez, Karen G, Pato, Michele T, Nicolini, Humberto, and Storch, Eric A

Subjects
Article
Abstract

Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, www.latinostudy.org ). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5,000 richly-phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.

Published
2023

4. Experience of Sexual Violence Among Women of Mexican Heritage Raised in the United States.

Author

Tummala-Narra, Pratyusha, Gonzalez, Laura D., and Nguyen, My Nguyen

Abstract

Sexual violence against women is a significant public health crisis that is understudied among Mexican American communities. Yet, there has been little attention directed to sociocultural factors that shape conceptualizations of and responses to sexual violence among Mexican American women. Guided by an integrative contextual framework, this qualitative study aimed to expand knowledge of how second generation Mexican American women conceptualize, experience, and respond to sexual violence. Semistructured interviews focused on conceptualizations of sexual violence, socialization concerning gender, sex, and sexual violence, experiences, and impact of sexual violence, coping, and help-seeking were conducted with 16 women between 20 and 38 years of age (M = 27.13). The interview data, analyzed using qualitative conventional content analysis, revealed four broad domains: (a) implicit and explicit messages about sexuality and sexual violence, (b) psychological consequences of sexual violence, (c) barriers to disclosing violence and seeking help, and (d) sources of resilience and healing. Findings indicated that conceptualizations of sexual violence and coping were influenced by complex interactions among several sociocultural contexts, including families, religious and ethnic communities, and the mainstream U.S. context. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Latin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol

Author

Crowley, James J., Cappi, Carolina, Ochoa‐Panaifo, Marcos E., Frederick, Renee M., Kook, Minjee, Wiese, Andrew D., Rancourt, Diana, Atkinson, Elizabeth G., Giusti‐Rodriguez, Paola, Anderberg, Jacey L., Abramowitz, Jonathan S, Adorno, Victor R, Aguirre, Cinthia, Alves, Gilberto S, Alves, Gustavo S, Ancalade, NaEshia, Anderberg, Jacey L, Arellano Espinosa, Alejandro A, Arnold, Paul D, Atkinson, Elizabeth G, Ayton, Daphne M, Barbosa, Izabela G, Castano, Laura Marcela Barón, Barrera, Cynthia N, Berardo, María Celeste, Berrones, Dayan, Best, John R, Bigdeli, Tim B, Borda, Tania, Burton, Christie L, Buxbaum, Joseph D, Callahan, Jennifer L, Cappi, Carolina, Carneiro, Maria Cecília B, Cepeda, Sandra L, Chazelle, Evelyn, Chire, Jessica M, Munoz, Macarena Churruca, Quiroz, Pamela Claisse, Cobite, Journa, Comer, Jonathan S, Costa, Daniel L, Crosbie, Jennifer, Crowley, James J, Cruz, Victor O, Dager, Guillermo, Daza, Luisa F, Rosa‐Gómez, Anabel, Río, Daniela, Delage, Fernanda Z, Dreher, Carolina B, Fay, Lucila, Fazio, Tomas, Ferrão, Ygor A, Ferreira, Gabriela M, Figueroa, Edith G, Fontenelle, Leonardo F, Forero, Diego A, Fragoso, Daniele TH, Frederick, Renee M, Gadad, Bharathi S, Garrison, Sheldon R, Giusti‐Rodriguez, Paola, Gonzalez, Laura D, González, Andres, González, Marco A, Gonzalez‐Barrios, Polaris, Goodman, Wayne, Grice, Dorothy E, Guintivano, Jerry, Guttfreund, Daniel G, Guzick, Andrew G, Halvorsen, Matthew W, Hovey, Joseph D, Huang, Hailiang, Irreño‐Sotomonte, Jonathan, Janssen‐Aguilar, Reinhard, Jensen, Matias, Jimenez Reynolds, Alexandra Z, Lujambio, Joali Alexandra Juárez, Khalfe, Nasim, Knutsen, Madison A, Kook, Minjee, Lack, Caleb, Lanzagorta, Nuria, Lázaro‐Muñoz, Gabriel, Lima, Monicke O, Longhurst, Melanie O, Lozada Martinez, David A, Luna, Elba S, Marques, Andrea H, Martinez, Molly, Martinez Mallen, Mayra C, Martinez‐Gonzalez, Karen G, Los Angeles Matos, Maria, Mattheisen, Manuel, Maye, Caitlyn E, McGuire, Joseph F, Menezes, Gabriela, Miguel, Euripedes C, Minaya, Charlene, Miño, Tomás, Mithani, Sara M, Oca, Circe Montes, Morales‐Rivero, Alonso, Moreira‐de‐Oliveira, Maria E, Morris, Olivia J, Moya, Pablo R, Moyano, María Beatriz, Muñoz, Sandra I, Naqqash, Zainab, Nicolini, Humberto, Núñez Bracho, Ambar A, Núñez Bracho, Belinda E, Rojas, Maria Corina Ochoa, Ochoa‐Panaifo, Marcos E, Olavarria Castaman, Luis A, Balmaceda, Trinidad Olivos, Ortega, Iliana, Patel, Darpan I, Pato, Michele T, Patrick, Ainsley K, Mino, Mariel Paz y, Perales Orellana, Jose L, Stumpf, Bárbara Perdigão, Peregrina, Tamara, Pereira, Stacey, Duarte, Tania Pérez, Piacsek, Kelly L, Placencia, Maritza, Prieto, María Belén, Quarantini, Lucas C, Quarantini‐Alvim, Yana, Ramos, Iaroslava C, Ramos, Renato T, Ramos, Vanessa R, Ramsey, Kesley A, Rancourt, Diana, Ray, Elise V, Richter, Margaret A, Riemann, Bradley C, Rivas, Juan C, Rodriguez, Carolyn I, Rosario, Maria C, Ruggero, Camilo J, Ruiz‐Chow, Angel A, Ruiz‐Velasco, Alejandra, Sagarnaga, Melisa N, Sampaio, Aline S, Saraiva, Leonardo C, Schachar, Russell J, Schneider, Sophie C, Schweissing, Ethan J, Seligman, Laura D, Shavitt, Roseli G, Soileau, Keaton J, Stewart, S. Evelyn, Storch, Eric A, Storch, Shaina B, Strouphauer, Emily R, Cuevas, Vissente Tapia, Timpano, Kiara R, Garza, Beatriz Treviño‐de, Vallejo‐Silva, Alexie, Vargas‐Medrano, Javier, Vásquez, María I, Martinez, Guadalupe Vidal, Weinzimmer, Saira A, Wiese, Andrew D, Yanez, Mauricio A, Zai, Gwyneth, Zapata‐Restrepo, Lina M, Zappa, Luz M, Zepeda‐Burgos, Raquel M, Zoghbi, Anthony W, Sampaio, Aline Santos, Hounie, Ana Gabriela, Ribeiro, Ana Paula, Souza e Silva, Angela Rodrigues, Martinho, Ariane Fadel, Stumpf, Bárbara Luciane Perdigão, Melo Fadel, Bianca Torres Mendonça, Porto, Camila Vale, Chacur, Carina Freitas, Loureiro, Carla Pereira, Dreher, Carolina Blaya, Cappi, Carolina, Bortoncello, Cristiane Flôres, Conceição Costa, Daniel Lucas, Fragoso, Daniele Tamae Hashimoto, Miguel, Euripedes Constantino, Delage, Fernanda Zetola, Cervone, Flávia, Menezes, Gabriela Bezerra, Souza Barros, Gabriela Cirqueira, Ferreira, Gabriela Mourão, Alves, Gilberto Sousa, Alves, Gustavo Santiago, Caminha, Hugo, Barbosa, Izabela Guimarães, Cenci, Jaqueline, Muhlbauer, Julia Fernandes Eigenheer, Silva, Juliana Rigue, Saraiva, Leonardo Cardoso, Costa Fontenelle, Leonardo Franklin, Camba Lopez, Lígia S., Faro, Livi Ferreira Testoni, Moreira, Luan Pinheiro Domingues, Laurito, Luana Dumans, Castro Quarantini, Lucas, Samezima, Luciana Midori, Santos Martins, Luiz Felipe Guimarães, Oliveira, Marcos Vinícius Sousa, Mathis, Maria Alice, Lopes, Maria Carolina Paraíso, Carneiro, Maria Cecília, Rosário, Maria Conceição, Oliveira, Maria Eduarda Ismerio Moreira, Pinho, Marina Martorelli, Oliveira Lima, Monicke, Nagano, Nádia, Danna, Patrycia Chedid, Silva, Pedro Pereira Fortes, Jesus Cardoso, Raquel Fernandes, Christo, Renan Barbosa, Avila, Richard Chuquel Silveira, Radins, Rodrigo Bolsson, Shavitt, Roseli Gedanke, Santos Ribeiro, Samara, Silveira Meirelles, Tatiane Veríssimo, Aguiar, Thays Mendes, Silva Sousa, Theresa Kerolayne, Vieira, Thiago Blanco, Ramos, Vanessa Rogério, Vasconcellos, Veronica Huhne, Alvim, Yana Quarantini, Ferrão, Ygor Arzeno, Abramowitz, Jonathan S., Adorno, Victor R., Aguirre, Cinthia, Alves, Gilberto S., Alves, Gustavo S., Ancalade, NaEshia, Arellano Espinosa, Alejandro A., Arnold, Paul D., Ayton, Daphne M., Barbosa, Izabela G., Castano, Laura Marcela Barón, Barrera, Cynthia N., Berardo, María Celeste, Berrones, Dayan, Best, John R., Bigdeli, Tim B., Burton, Christie L., Buxbaum, Joseph D., Callahan, Jennifer L., Carneiro, Maria Cecília B., Cepeda, Sandra L., Chazelle, Evelyn, Chire, Jessica M., Munoz, Macarena Churruca, Quiroz, Pamela Claisse, Cobite, Journa, Comer, Jonathan S., Costa, Daniel L., Crosbie, Jennifer, Cruz, Victor O., Dager, Guillermo, Daza, Luisa F., Rosa‐Gómez, Anabel, Río, Daniela, Delage, Fernanda Z., Dreher, Carolina B., Fay, Lucila, Fazio, Tomas, Ferrão, Ygor A., Ferreira, Gabriela M., Figueroa, Edith G., Fontenelle, Leonardo F., Forero, Diego A., Fragoso, Daniele T. H., Gadad, Bharathi S., Garrison, Sheldon R., González, Andres, Gonzalez, Laura D., González, Marco A., Gonzalez‐Barrios, Polaris, Goodman, Wayne K., Grice, Dorothy E., Guintivano, Jerry, Guttfreund, Daniel G., Guzick, Andrew G., Halvorsen, Matthew W., Hovey, Joseph D., Huang, Hailiang, Irreño‐Sotomonte, Jonathan, Janssen‐Aguilar, Reinhard, Jensen, Matias, Jimenez Reynolds, Alexandra Z., Lujambio, Joali Alexandra Juárez, Khalfe, Nasim, Knutsen, Madison A., Lack, Caleb, Lanzagorta, Nuria, Lima, Monicke O., Longhurst, Melanie O., Lozada Martinez, David A., Luna, Elba S., Marques, Andrea H., Martinez, Molly S., Los Angeles Matos, Maria, Maye, Caitlyn E., McGuire, Joseph F., Menezes, Gabriela, Minaya, Charlene, Miño, Tomás, Mithani, Sara M., Oca, Circe Montes, Morales‐Rivero, Alonso, Moreira‐de‐Oliveira, Maria E., Morris, Olivia J., Muñoz, Sandra I., Naqqash, Zainab, Núñez Bracho, Ambar A., Núñez Bracho, Belinda E., Rojas, Maria Corina Ochoa, Olavarria Castaman, Luis A., Balmaceda, Trinidad Olivos, Ortega, Iliana, Patel, Darpan I., Patrick, Ainsley K., Paz y Mino, Mariel, Perales Orellana, Jose L., Stumpf, Bárbara Perdigão, Peregrina, Tamara, Duarte, Tania Pérez, Piacsek, Kelly L., Placencia, Maritza, Prieto, María Belén, Quarantini, Lucas C., Quarantini‐Alvim, Yana, Ramos, Renato T., Ramos, Iaroslava C., Ramos, Vanessa R., Ramsey, Kesley A., Ray, Elise V., Richter, Margaret A., Riemann, Bradley C., Rivas, Juan C., Rosario, Maria C., Ruggero, Camilo J., Ruiz‐Chow, Angel A., Ruiz‐Velasco, Alejandra, Sagarnaga, Melisa N., Sampaio, Aline S., Saraiva, Leonardo C., Schachar, Russell J., Schneider, Sophie C., Schweissing, Ethan J., Seligman, Laura D., Shavitt, Roseli G., Soileau, Keaton J., Stewart, S. Evelyn, Storch, Shaina B., Strouphauer, Emily R., Cuevas, Vissente Tapia, Timpano, Kiara R., Garza, Beatriz Treviño‐de, Vallejo‐Silva, Alexie, Vargas‐Medrano, Javier, Vásquez, María I., Martinez, Guadalupe Vidal, Weinzimmer, Saira A., Yanez, Mauricio A., Zai, Gwyneth, Zapata‐Restrepo, Lina M., Zappa, Luz M., Zepeda‐Burgos, Raquel M., Zoghbi, Anthony W., Miguel, Euripedes C., Rodriguez, Carolyn I., Martinez Mallen, Mayra C., Moya, Pablo R., Borda, Tania, Moyano, María Beatriz, Mattheisen, Manuel, Pereira, Stacey, Lázaro‐Muñoz, Gabriel, Martinez‐Gonzalez, Karen G., Pato, Michele T., Nicolini, Humberto, and Storch, Eric A.

Abstract

Obsessive‐compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long‐sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans‐ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans‐ancestry genomic analyses to accelerate the identification of OCD risk loci, fine‐map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.

Published
2024
Full Text
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6. A school district's decision-making process regarding implementation of school choice : the case of one Texas public school district

Author

Carlin-Gonzalez, Laura D.

Subjects
Superintendent, ComputingMilieux_COMPUTERSANDEDUCATION, School district, School choice, Decision-making
Abstract

As school districts are challenged with facing the many demands of meeting the needs of all students, school choice is presented as one way to meet those needs. School choice is anchored in the economic theory of competition in that if parents and students are offered options for choice, then they will choose the best educational opportunities presented. In addition, if competition is injected into the educational system, all schools will improve as a result. Benefits and challenges have been identified regarding school choice. Despite the challenges, many traditional public-school superintendents and school leaders consider school choice implementation as a method of school reform. While there has been research regarding school choice benefits and challenges, further exploration was warranted regarding the decision-making process used to consider whether or not to implement school choice. The purpose of this study was to determine the decision-making process employed to decide whether or not to implement schools of choice within a single school district. It also focused on what factors contributed to the exploration of school choice implementation, and how the specific process employed, by the school superintendent, was influenced by the emerging factors considered for choice implementation. Thus, the researcher explored the actions taken by the superintendent and district leaders as they considered school choice implementation. The researcher employed a constructionism epistemology with a qualitative single case study approach. Data was collected, coded, and analyzed using a deductive process. The researcher used multiple data sources in order to triangulate the data. Findings suggested that factors that influenced the superintendent and school district leaders to explore school choice implementation were competition with neighboring schools, student achievement and student interests, and building on early successes. The findings further revealed the decision-making process employed by the district that included five phases: setting a vision, gathering data, soliciting community input, researching programs based on data, and creating tightly aligned implementation plans. The findings of the study discovered that the emerging factors influenced the decision-making process to be student-centered, highly data-driven and research based, and collaborative.

Published
2020
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8. Culture of Shame: An Exploration of Shame Among Mexican American Survivors of Sexual Violence

Author

Gonzalez, Laura D. (Gonzalez, Laura D.)

Subjects
Immigrant, Latinx, Mexican American, Sexual Violence, Trauma, Women
Abstract

Sexual violence is a common experience among women in the United States that can have a number of negative sequalae, including heightened feelings of shame (Feiring & Taska, 2005; Smith et al., 2018). While literature has started to document the effects of shame on some aspects of survivors’ lives (Bhuptani et al., 2019; Kim et al., 2009), less is known about how shame is experienced by survivors in their daily lives. Mexican Americans constitute a notable segment of the U.S. population and are affected by unique contextual factors such as their immigration history, cultural values, religious experiences, and acculturation processes. Yet, there is limited literature examining the experiences of Mexican American survivors of sexual violence. Using Campbell and colleagues’ (2009) ecological model and a mujerista research paradigm (Bryant-Davis & Comas-Díaz, 2016), this study sought to develop a qualitative understanding of the experience of shame among 1.5 and 2nd generation Mexican American women who are survivors of sexual violence, while considering how cultural values and beliefs shape their experience of shame across ecological levels. Twelve 1.5 and 2nd generation Mexican American survivors of sexual violence participated in semi-structured interviews for this qualitative descriptive study. Conventional content analysis of the data yielded eight broad domains: (1) influence of immigration and cultural context on shame; (2) impact of shame on mental health; (3) relational impacts of shame; (4) impact of shame on daily functioning; (5) impact of shame on disclosure; (6) marianismo increased feelings of shame after sexual violence; (7) healing from shame; and, (8) challenges to healing from shame. Results indicate that the effects of shame are pervasive for survivors across multiple areas of their lives (i.e., mental and physical health, relationships, academic and professional lives), religious and cultural messages foster a context of shame for survivors, and survivors’ healing process is shaped by their bicultural context. Limitations and theoretical implications of these findings are discussed, along with implications for culturally responsive clinical practice and future research directions.

Published
2021

9. Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study Protocol.

Author

Crowley JJ, Cappi C, Ochoa-Panaifo ME, Frederick RM, Kook M, Wiese AD, Rancourt D, Atkinson EG, Giusti-Rodriguez P, Anderberg JL, Abramowitz JS, Adorno VR, Aguirre C, Alves GS, Alves GS, Ancalade N, Espinosa AAA, Arnold PD, Ayton DM, Barbosa IG, Castano LMB, Barrera CN, Prieto MB, Berardo MC, Berrones D, Best JR, Bigdeli TB, Burton CL, Callahan JL, Carneiro MCB, Cepeda SL, Chazelle E, Chire JM, Munoz MC, Quiroz PC, Cobite J, Comer JS, Costa DL, Crosbie J, Cruz VO, Dager G, Daza LF, de la Rosa-Gómez A, Del Río D, Delage FZ, Dreher CB, Fay L, Fazio T, Ferrão YA, Ferreira GM, Figueroa EG, Fontenelle LF, Forero DA, Fragoso DT, Gadad BS, Garrison SR, González A, Gonzalez LD, González MA, Gonzalez-Barrios P, Goodman W, Guintivano J, Guttfreund DG, Guzick AG, Halvorsen MW, Hovey JD, Janssen-Aguilar R, Jensen M, Reynolds AZJ, Lujambio JAJ, Khalfe N, Knutsen MA, Lack C, Lanzagorta N, Lima MO, Longhurst MO, Martinez DAL, Luna ES, Marques AH, Martinez M, de Los Angeles Matos M, Maye CE, McGuire JF, Menezes G, Minaya C, Miño T, Mithani SM, de Oca CM, Morales-Rivero A, Moreira-de-Oliveira ME, Morris OJ, Muñoz SI, Naqqash Z, Bracho AAN, Bracho BEN, Rojas MCO, Castaman LAO, Ortega I, Patel DI, Patrick AK, Mino MPY, Orellana JLP, Stumpf BP, Peregrina T, Duarte TP, Piacsek KL, Placencia M, Quarantini LC, Quarantini-Alvim Y, Ramos RT, Ramos IC, Ramos VR, Ramsey KA, Ray EV, Richter MA, Riemann BC, Rivas JC, Rosario MC, Ruggero CJ, Ruiz-Chow AA, Ruiz-Velasco A, Sampaio AS, Saraiva LC, Schachar RJ, Schneider SC, Schweissing EJ, Seligman LD, Shavitt RG, Soileau KJ, Stewart SE, Storch SB, Strouphauer ER, Timpano KR, Treviño-de la Garza B, Vargas-Medrano J, Vásquez MI, Martinez GV, Weinzimmer SA, Yanez MA, Zai G, Zapata-Restrepo LM, Zappa LM, Zepeda-Burgos RM, Zoghbi AW, Miguel EC, Rodriguez CI, Mallen MCM, Moya PR, Borda T, Moyano MB, Mattheisen M, Pereira S, Lázaro-Muñoz G, Martinez-Gonzalez KG, Pato MT, Nicolini H, and Storch EA

Abstract

Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5,000 richly-phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.

Published
2023
Full Text
View/download PDF

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