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1. The Gaia-ESO Survey: Homogenisation of stellar parameters and elemental abundances

Author

Universidad de Alicante. Departamento de Física Aplicada, Hourihane, A., François, P., Worley, C.C., Magrini, L., Gonneau, A., Casey, A.R., Gilmore, Gerard, Randich, Sofia, Sacco, G.G., Recio-Blanco, A., Korn, A., Allende Prieto, C., Smiljanic, R., Blomme, Ronny, Bragaglia, A., Walton, N., Van Eck, S., Bensby, T., Lanzafame, A.C., Frasca, A., Franciosini, E., Damiani, F., Lind, K., Bergemann, M., Bonifacio, P., Hill, V., Lobel, Alex, Montes, David, Feuillet, D.K., Tautvaišienė, G., Guiglion, G., Tabernero, Hugo M., González Hernández, J.I., Gebran, M., Van der Swaelmen, M., Mikolaitis, Š., Daflon, Simone, Merle, T., Morel, Thierry, Lewis, J., González Solares, E.A., Murphy, D.N.A., Jeffries, R., Jackson, R.J., Feltzing, S., Prusti, T., Carraro, G., Biazzo, K., Prisinzano, L., Jofre, P., Zaggia, S., Drazdauskas, A., Stonkuté, E., Marfil, E., Jiménez Esteban, Francisco M., Mahy, Laurent, Gutiérrez Albarrán, M.L., Berlanas, Sara R., Santos, W., Morbidelli, L., Spina, L., Minkevičiūtė, R., Universidad de Alicante. Departamento de Física Aplicada, Hourihane, A., François, P., Worley, C.C., Magrini, L., Gonneau, A., Casey, A.R., Gilmore, Gerard, Randich, Sofia, Sacco, G.G., Recio-Blanco, A., Korn, A., Allende Prieto, C., Smiljanic, R., Blomme, Ronny, Bragaglia, A., Walton, N., Van Eck, S., Bensby, T., Lanzafame, A.C., Frasca, A., Franciosini, E., Damiani, F., Lind, K., Bergemann, M., Bonifacio, P., Hill, V., Lobel, Alex, Montes, David, Feuillet, D.K., Tautvaišienė, G., Guiglion, G., Tabernero, Hugo M., González Hernández, J.I., Gebran, M., Van der Swaelmen, M., Mikolaitis, Š., Daflon, Simone, Merle, T., Morel, Thierry, Lewis, J., González Solares, E.A., Murphy, D.N.A., Jeffries, R., Jackson, R.J., Feltzing, S., Prusti, T., Carraro, G., Biazzo, K., Prisinzano, L., Jofre, P., Zaggia, S., Drazdauskas, A., Stonkuté, E., Marfil, E., Jiménez Esteban, Francisco M., Mahy, Laurent, Gutiérrez Albarrán, M.L., Berlanas, Sara R., Santos, W., Morbidelli, L., Spina, L., and Minkevičiūtė, R.

Abstract

The Gaia-ESO Survey is a public spectroscopic survey that targeted ≳105 stars covering all major components of the Milky Way from the end of 2011 to 2018, delivering its final public release in May 2022. Unlike other spectroscopic surveys, Gaia-ESO is the only survey that observed stars across all spectral types with dedicated, specialised analyses: from O (Teff ~ 30 000–52 000 K) all the way to K-M (≳3500 K). The physics throughout these stellar regimes varies significantly, which has previously prohibited any detailed comparisons between stars of significantly different types. In the final data release (internal data release 6) of the Gaia-ESO Survey, we provide the final database containing a large number of products, such as radial velocities, stellar parameters and elemental abundances, rotational velocity, and also, for example, activity and accretion indicators in young stars and membership probability in star clusters for more than 114 000 stars. The spectral analysis is coordinated by a number of working groups (WGs) within the survey, each specialised in one or more of the various stellar samples. Common targets are analysed across WGs to allow for comparisons (and calibrations) amongst instrumental setups and spectral types. Here we describe the procedures employed to ensure all survey results are placed on a common scale in order to arrive at a single set of recommended results for use by all survey collaborators. We also present some general quality and consistency checks performed on the entirety of the survey results.

Published
2023

2. The Gaia-ESO Public Spectroscopic Survey: Implementation, data products, open cluster survey, science, and legacy

Author

Universidad de Alicante. Departamento de Física Aplicada, Randich, Sofia, Gilmore, Gerard, Magrini, L., Sacco, G.G., Jackson, R.J., Jeffries, R., Worley, C.C., Hourihane, A., Gonneau, A., Viscasillas Vázquez, C., Franciosini, E., Sbordone, L., Sousa, S.G., Zaggia, S., Adibekyan, V.Zh., Bonito, R., Caffau, E., Daflon, Simone, Feuillet, D.K., Drazdauskas, A., Gebran, M., Lagarde, N., González Hernández, J.I., Guiglion, G., Herrero, Artemio, Lobel, Alex, Maíz Apellániz, Jesús, Merle, T., Mikolaitis, Š., Montes, David, Morel, Thierry, Evans, N.W., Mahy, Laurent, Soubiran, C., Spina, L., Tabernero, Hugo M., Tautvaišienė, G., Traven, G., Valentini, M., Van der Swaelmen, M., Villanova, S., Wright, N.J., Abbas, U., Mapelli, M., Famaey, B., Aguirre Børsen-Koch, V., Alves, J., Balaguer-Nunez, L., Barklem, P.S., Barrado, D., Berlanas, Sara R., Binks, A.S., Bressan, A., Capuzzo-Dolcetta, R., Marfil, E., Casagrande, L., Franchini, M., Casamiquela, L., Collins, R.S., D'Orazi, V., Dantas, M.L.L., Debattista, V.P., Frémat, Y., Friel, E., Fu, X., Martell, S.L., Geisler, Douglas, Lewis, J., Gerhard, Ortwin, González Solares, E.A., Grebel, E.K., Gutiérrez Albarran, M.L., Hatzidimitriou, D., Held, E.V., Jiménez Esteban, Francisco M., Jönsson, H., Messina, S., Jordi, C., Khachaturyants, T., Alfaro, Emilio J., Kordopatis, G., Kos, J., Miglio, A., Minchev, I., Allende Prieto, C., Moitinho, A., Negueruela, Ignacio, Montalban, J., Monteiro, M.J.P.F.G., Morossi, C., Mowlavi, N., Mucciarelli, A., Murphy, D.N.A., Nardetto, N., Ortolani, S., Paletou, F., Bensby, T., Prusti, T., Palouš, J., Paunzen, E., Pickering, J.C., Quirrenbach, A., Re Fiorentin, P., Read, J.I., Romano, D., Ryde, N., Sanna, N., Santos, W., Rix, H.-W., Blomme, Ronny, Seabroke, G.M., Spagna, A., Steinmetz, M., Stonkuté, E., Sutorius, E., Thévenin, F., Tosi, M., Tsantaki, M., Vink, Jorick S., Vallenari, A., Wright, N., Bragaglia, A., Wyse, R.F.G., Zoccali, M., Zorec, J., Zucker, D.B., Walton, N., Flaccomio, E., François, P., Irwin, M., Bayo, A., Koposov, S., Korn, A., Lanzafame, A.C., Pancino, E., Recio-Blanco, A., Smiljanic, R., Van Eck, S., Zwitter, T., Asplund, M., Bonifacio, P., Bergemann, M., Feltzing, S., Binney, J., Drew, J., Ferguson, A., Micela, G., Biazzo, K., Carraro, G., Casey, A.R., Damiani, F., Delgado-Mena, E., Frasca, A., Heiter, U., Hill, V., Jofre, P., Laverny, P. de, Lind, K., Marconi, G., Martayan, C., Masseron, T., Monaco, L., Di Marcantonio, P., Morbidelli, L., Prisinzano, L., Universidad de Alicante. Departamento de Física Aplicada, Randich, Sofia, Gilmore, Gerard, Magrini, L., Sacco, G.G., Jackson, R.J., Jeffries, R., Worley, C.C., Hourihane, A., Gonneau, A., Viscasillas Vázquez, C., Franciosini, E., Sbordone, L., Sousa, S.G., Zaggia, S., Adibekyan, V.Zh., Bonito, R., Caffau, E., Daflon, Simone, Feuillet, D.K., Drazdauskas, A., Gebran, M., Lagarde, N., González Hernández, J.I., Guiglion, G., Herrero, Artemio, Lobel, Alex, Maíz Apellániz, Jesús, Merle, T., Mikolaitis, Š., Montes, David, Morel, Thierry, Evans, N.W., Mahy, Laurent, Soubiran, C., Spina, L., Tabernero, Hugo M., Tautvaišienė, G., Traven, G., Valentini, M., Van der Swaelmen, M., Villanova, S., Wright, N.J., Abbas, U., Mapelli, M., Famaey, B., Aguirre Børsen-Koch, V., Alves, J., Balaguer-Nunez, L., Barklem, P.S., Barrado, D., Berlanas, Sara R., Binks, A.S., Bressan, A., Capuzzo-Dolcetta, R., Marfil, E., Casagrande, L., Franchini, M., Casamiquela, L., Collins, R.S., D'Orazi, V., Dantas, M.L.L., Debattista, V.P., Frémat, Y., Friel, E., Fu, X., Martell, S.L., Geisler, Douglas, Lewis, J., Gerhard, Ortwin, González Solares, E.A., Grebel, E.K., Gutiérrez Albarran, M.L., Hatzidimitriou, D., Held, E.V., Jiménez Esteban, Francisco M., Jönsson, H., Messina, S., Jordi, C., Khachaturyants, T., Alfaro, Emilio J., Kordopatis, G., Kos, J., Miglio, A., Minchev, I., Allende Prieto, C., Moitinho, A., Negueruela, Ignacio, Montalban, J., Monteiro, M.J.P.F.G., Morossi, C., Mowlavi, N., Mucciarelli, A., Murphy, D.N.A., Nardetto, N., Ortolani, S., Paletou, F., Bensby, T., Prusti, T., Palouš, J., Paunzen, E., Pickering, J.C., Quirrenbach, A., Re Fiorentin, P., Read, J.I., Romano, D., Ryde, N., Sanna, N., Santos, W., Rix, H.-W., Blomme, Ronny, Seabroke, G.M., Spagna, A., Steinmetz, M., Stonkuté, E., Sutorius, E., Thévenin, F., Tosi, M., Tsantaki, M., Vink, Jorick S., Vallenari, A., Wright, N., Bragaglia, A., Wyse, R.F.G., Zoccali, M., Zorec, J., Zucker, D.B., Walton, N., Flaccomio, E., François, P., Irwin, M., Bayo, A., Koposov, S., Korn, A., Lanzafame, A.C., Pancino, E., Recio-Blanco, A., Smiljanic, R., Van Eck, S., Zwitter, T., Asplund, M., Bonifacio, P., Bergemann, M., Feltzing, S., Binney, J., Drew, J., Ferguson, A., Micela, G., Biazzo, K., Carraro, G., Casey, A.R., Damiani, F., Delgado-Mena, E., Frasca, A., Heiter, U., Hill, V., Jofre, P., Laverny, P. de, Lind, K., Marconi, G., Martayan, C., Masseron, T., Monaco, L., Di Marcantonio, P., Morbidelli, L., and Prisinzano, L.

Abstract

Context. In the last 15 years different ground-based spectroscopic surveys have been started (and completed) with the general aim of delivering stellar parameters and elemental abundances for large samples of Galactic stars, complementing Gaia astrometry. Among those surveys, the Gaia-ESO Public Spectroscopic Survey, the only one performed on a 8m class telescope, was designed to target 100 000 stars using FLAMES on the ESO VLT (both Giraffe and UVES spectrographs), covering all the Milky Way populations, with a special focus on open star clusters. Aims. This article provides an overview of the survey implementation (observations, data quality, analysis and its success, data products, and releases), of the open cluster survey, of the science results and potential, and of the survey legacy. A companion article reviews the overall survey motivation, strategy, Giraffe pipeline data reduction, organisation, and workflow. Methods. We made use of the information recorded and archived in the observing blocks; during the observing runs; in a number of relevant documents; in the spectra and master catalogue of spectra; in the parameters delivered by the analysis nodes and the working groups; in the final catalogue; and in the science papers. Based on these sources, we critically analyse and discuss the output and products of the Survey, including science highlights. We also determined the average metallicities of the open clusters observed as science targets and of a sample of clusters whose spectra were retrieved from the ESO archive. Results. The Gaia-ESO Survey has determined homogeneous good-quality radial velocities and stellar parameters for a large fraction of its more than 110 000 unique target stars. Elemental abundances were derived for up to 31 elements for targets observed with UVES. Lithium abundances are delivered for about 1/3 of the sample. The analysis and homogenisation strategies have proven to be successful; several science topics have been addressed by t

Published
2022

3. The Gaia-ESO Public Spectroscopic Survey: Motivation, implementation, GIRAFFE data processing, analysis, and final data products

Author

Universidad de Alicante. Departamento de Física Aplicada, Gilmore, Gerard, Randich, Sofia, Worley, C.C., Hourihane, A., Gonneau, A., Sacco, G.G., Lewis, J., Magrini, L., François, P., Jeffries, R., Koposov, S., Binks, A.S., Bressan, A., Capuzzo-Dolcetta, R., Casagrande, L., Casamiquela, L., Collins, R.S., D'Orazi, V., Dantas, M.L.L., Debattista, V.P., Delgado-Mena, E., Bragaglia, A., Di Marcantonio, P., Drazdauskas, A., Evans, N.W., Famaey, B., Franchini, M., Frémat, Y., Fu, X., Geisler, Douglas, Gerhard, Ortwin, González Solares, E.A., Alfaro, Emilio J., Grebel, E.K., Gutiérrez Albarrán, M.L., Jiménez Esteban, Francisco M., Jönsson, H., Khachaturyants, T., Kordopatis, G., Kos, J., Lagarde, N., Ludwig, H.-G., Mahy, Laurent, Allende Prieto, C., Mapelli, M., Marfil, E., Martell, S.L., Messina, S., Miglio, A., Minchev, I., Moitinho, A., Montalban, J., Monteiro, M.J.P.F.G., Morossi, C., Blomme, Ronny, Mowlavi, N., Mucciarelli, A., Murphy, D.N.A., Nardetto, N., Ortolani, S., Paletou, F., Palouš, J., Pickering, J.C., Quirrenbach, A., Re Fiorentin, P., Korn, A., Read, J.I., Romano, D., Ryde, N., Sanna, N., Santos, W., Seabroke, G.M., Spina, L., Steinmetz, M., Stonkuté, E., Sutorius, E., Lanzafame, A.C., Thévenin, F., Tosi, M., Tsantaki, M., Wright, N., Wyse, R.F.G., Zoccali, M., Zorec, J., Zucker, D.B., Pancino, E., Recio-Blanco, A., Smiljanic, R., Van Eck, S., Zwitter, T., Bensby, T., Flaccomio, E., Irwin, M., Franciosini, E., Morbidelli, L., Damiani, F., Bonito, R., Friel, E., Vink, Jorick S., Prisinzano, L., Abbas, U., Hatzidimitriou, D., Held, E.V., Jordi, C., Paunzen, E., Spagna, A., Jackson, R.J., Maíz Apellániz, Jesús, Asplund, M., Bonifacio, P., Feltzing, S., Binney, J., Drew, J., Ferguson, A., Micela, G., Negueruela, Ignacio, Prusti, T., Rix, H.-W., Vallenari, A., Bergemann, M., Casey, A.R., Laverny, P. de, Frasca, A., Hill, V., Lind, K., Sbordone, L., Sousa, S.G., Adibekyan, V.Zh., Caffau, E., Daflon, Simone, Feuillet, D.K., Gebran, M., González Hernández, J.I., Guiglion, G., Herrero, Artemio, Lobel, Alex, Merle, T., Mikolaitis, Š., Montes, David, Morel, Thierry, Ruchti, G., Soubiran, C., Tabernero, Hugo M., Tautvaišienė, G., Traven, G., Valentini, M., Van der Swaelmen, M., Villanova, S., Viscasillas Vázquez, C., Bayo, A., Biazzo, K., Carraro, G., Edvardsson, B., Heiter, U., Jofre, P., Marconi, G., Martayan, C., Masseron, T., Monaco, L., Walton, N., Zaggia, S., Aguirre Børsen-Koch, V., Alves, J., Balaguer-Nunez, L., Barklem, P.S., Barrado, D., Bellazzini, M., Berlanas, Sara R., Universidad de Alicante. Departamento de Física Aplicada, Gilmore, Gerard, Randich, Sofia, Worley, C.C., Hourihane, A., Gonneau, A., Sacco, G.G., Lewis, J., Magrini, L., François, P., Jeffries, R., Koposov, S., Binks, A.S., Bressan, A., Capuzzo-Dolcetta, R., Casagrande, L., Casamiquela, L., Collins, R.S., D'Orazi, V., Dantas, M.L.L., Debattista, V.P., Delgado-Mena, E., Bragaglia, A., Di Marcantonio, P., Drazdauskas, A., Evans, N.W., Famaey, B., Franchini, M., Frémat, Y., Fu, X., Geisler, Douglas, Gerhard, Ortwin, González Solares, E.A., Alfaro, Emilio J., Grebel, E.K., Gutiérrez Albarrán, M.L., Jiménez Esteban, Francisco M., Jönsson, H., Khachaturyants, T., Kordopatis, G., Kos, J., Lagarde, N., Ludwig, H.-G., Mahy, Laurent, Allende Prieto, C., Mapelli, M., Marfil, E., Martell, S.L., Messina, S., Miglio, A., Minchev, I., Moitinho, A., Montalban, J., Monteiro, M.J.P.F.G., Morossi, C., Blomme, Ronny, Mowlavi, N., Mucciarelli, A., Murphy, D.N.A., Nardetto, N., Ortolani, S., Paletou, F., Palouš, J., Pickering, J.C., Quirrenbach, A., Re Fiorentin, P., Korn, A., Read, J.I., Romano, D., Ryde, N., Sanna, N., Santos, W., Seabroke, G.M., Spina, L., Steinmetz, M., Stonkuté, E., Sutorius, E., Lanzafame, A.C., Thévenin, F., Tosi, M., Tsantaki, M., Wright, N., Wyse, R.F.G., Zoccali, M., Zorec, J., Zucker, D.B., Pancino, E., Recio-Blanco, A., Smiljanic, R., Van Eck, S., Zwitter, T., Bensby, T., Flaccomio, E., Irwin, M., Franciosini, E., Morbidelli, L., Damiani, F., Bonito, R., Friel, E., Vink, Jorick S., Prisinzano, L., Abbas, U., Hatzidimitriou, D., Held, E.V., Jordi, C., Paunzen, E., Spagna, A., Jackson, R.J., Maíz Apellániz, Jesús, Asplund, M., Bonifacio, P., Feltzing, S., Binney, J., Drew, J., Ferguson, A., Micela, G., Negueruela, Ignacio, Prusti, T., Rix, H.-W., Vallenari, A., Bergemann, M., Casey, A.R., Laverny, P. de, Frasca, A., Hill, V., Lind, K., Sbordone, L., Sousa, S.G., Adibekyan, V.Zh., Caffau, E., Daflon, Simone, Feuillet, D.K., Gebran, M., González Hernández, J.I., Guiglion, G., Herrero, Artemio, Lobel, Alex, Merle, T., Mikolaitis, Š., Montes, David, Morel, Thierry, Ruchti, G., Soubiran, C., Tabernero, Hugo M., Tautvaišienė, G., Traven, G., Valentini, M., Van der Swaelmen, M., Villanova, S., Viscasillas Vázquez, C., Bayo, A., Biazzo, K., Carraro, G., Edvardsson, B., Heiter, U., Jofre, P., Marconi, G., Martayan, C., Masseron, T., Monaco, L., Walton, N., Zaggia, S., Aguirre Børsen-Koch, V., Alves, J., Balaguer-Nunez, L., Barklem, P.S., Barrado, D., Bellazzini, M., and Berlanas, Sara R.

Abstract

Context. The Gaia-ESO Public Spectroscopic Survey is an ambitious project designed to obtain astrophysical parameters and elemental abundances for 100 000 stars, including large representative samples of the stellar populations in the Galaxy, and a well-defined sample of 60 (plus 20 archive) open clusters. We provide internally consistent results calibrated on benchmark stars and star clusters, extending across a very wide range of abundances and ages. This provides a legacy data set of intrinsic value, and equally a large wide-ranging dataset that is of value for the homogenisation of other and future stellar surveys and Gaia's astrophysical parameters. Aims. This article provides an overview of the survey methodology, the scientific aims, and the implementation, including a description of the data processing for the GIRAFFE spectra. A companion paper introduces the survey results. Methods. Gaia-ESO aspires to quantify both random and systematic contributions to measurement uncertainties. Thus, all available spectroscopic analysis techniques are utilised, each spectrum being analysed by up to several different analysis pipelines, with considerable effort being made to homogenise and calibrate the resulting parameters. We describe here the sequence of activities up to delivery of processed data products to the ESO Science Archive Facility for open use. Results. The Gaia-ESO Survey obtained 202 000 spectra of 115 000 stars using 340 allocated VLT nights between December 2011 and January 2018 from GIRAFFE and UVES. Conclusions. The full consistently reduced final data set of spectra was released through the ESO Science Archive Facility in late 2020, with the full astrophysical parameters sets following in 2022. A companion article reviews the survey implementation, scientific highlights, the open cluster survey, and data products.

Published
2022

4. Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response

Author

Sabina S Cosulich, Abigail Shea, Maurizio Callari, A. Dariush, Elena Provenzano, Martin O'Reilly, Carlos Caldas, Dimitra Georgopoulou, Agnese Giovannetti, Oscar M. Rueda, Gregory J. Hannon, Suet-Feung Chin, Giulia Lerda, Elham Esmaeilishirazifard, Alistair Martin, Violeta Serra, Fatime Qosaj, Wendy Greenwood, Dario Bressan, Larissa S. Carnevalli, Alejandra Bruna, H. Raza Ali, Gordon B. Mills, Rueda, Oscar M [0000-0003-0008-4884], Giovannetti, Agnese [0000-0001-5207-7243], Chin, Suet-Feung [0000-0001-5697-1082], Carnevalli, Larissa S [0000-0001-7432-0195], Provenzano, Elena [0000-0003-3345-3965], Serra, Violeta [0000-0001-6620-1065], Bressan, Dario [0000-0003-3592-699X], Mills, Gordon B [0000-0002-0144-9614], Ali, H Raza [0000-0001-7587-0906], Caldas, Carlos [0000-0003-3547-1489], Apollo - University of Cambridge Repository, IMAXT Consortium, Ali, H.R., Al Sa'd, M., Alon, S., Aparicio, S., Battistoni, G., Balasubramanian, S., Becker, R., Bodenmiller, B., Boyden, E.S., Bressan, D., Bruna, A., Burger, M., Caldas, C., Callari, M., Cannell, I.G., Casbolt, H., Chornay, N., Cui, Y., Dariush, A., Dinh, K., Emenari, A., Eyal-Lubling, Y., Fan, J., Fatemi, A., Fisher, E., González-Solares, E.A., González-Fernández, C., Goodwin, D., Greenwood, W., Grimaldi, F., Hannon, G.J., Harris, O., Harris, S., Jauset, C., Joyce, J.A., Karagiannis, E.D., Kovačević, T., Kuett, L., Kunes, R., Küpcü, Y.A., Lai, D., Laks, E., Lee, H., Lee, M., Lerda, G., Li, Y., McPherson, A., Millar, N., Mulvey, C.M., Nugent, F., O'Flanagan, C.H., Paez-Ribes, M., Pearsall, I., Qosaj, F., Roth, A.J., Rueda, O.M., Ruiz, T., Sawicka, K., Sepúlveda, L.A., Shah, S.P., Shea, A., Sinha, A., Smith, A., Tavaré, S., Tietscher, S., Vázquez-García, I., Vogl, S.L., Walton, N.A., Wassie, A.T., Watson, S.S., Weselak, J., Wild, S.A., Williams, E., Windhager, J., Whitmarsh, T., Xia, C., Zheng, P., and Zhuang, X.

Subjects
0301 basic medicine, Pyridines, Science, Tumour heterogeneity, Morpholines, Cell, General Physics and Astronomy, Breast Neoplasms, Drug resistance, Mice, SCID, Biology, Animals, Benzamides/pharmacology, Breast Neoplasms/drug therapy, Breast Neoplasms/genetics, Breast Neoplasms/metabolism, Cell Line, Tumor, Drug Resistance, Neoplasm/drug effects, Drug Resistance, Neoplasm/genetics, Female, Heterografts/drug effects, Heterografts/metabolism, Humans, MCF-7 Cells, Mice, Inbred NOD, Mice, Knockout, Morpholines/pharmacology, Piperazines/pharmacology, Protein Kinase Inhibitors/pharmacology, Pyridines/pharmacology, Pyrimidines/pharmacology, Treatment Outcome, Xenograft Model Antitumor Assays/methods, General Biochemistry, Genetics and Molecular Biology, Article, Piperazines, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, medicine, Mass cytometry, Protein Kinase Inhibitors, Multidisciplinary, Genetic heterogeneity, Cancer, General Chemistry, medicine.disease, Biobank, Phenotype, Xenograft Model Antitumor Assays, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, Pyrimidines, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Benzamides, Cancer research, Heterografts
Abstract

The heterogeneity of breast cancer plays a major role in drug response and resistance and has been extensively characterized at the genomic level. Here, a single-cell breast cancer mass cytometry (BCMC) panel is optimized to identify cell phenotypes and their oncogenic signalling states in a biobank of patient-derived tumour xenograft (PDTX) models representing the diversity of human breast cancer. The BCMC panel identifies 13 cellular phenotypes (11 human and 2 murine), associated with both breast cancer subtypes and specific genomic features. Pre-treatment cellular phenotypic composition is a determinant of response to anticancer therapies. Single-cell profiling also reveals drug-induced cellular phenotypic dynamics, unravelling previously unnoticed intra-tumour response diversity. The comprehensive view of the landscapes of cellular phenotypic heterogeneity in PDTXs uncovered by the BCMC panel, which is mirrored in primary human tumours, has profound implications for understanding and predicting therapy response and resistance., The heterogeneity of breast cancer has a major role in drug response and resistance. In this study, the authors use patient-derived tumour xenografts as a platform for drug testing and correlation with single-cell proteomic phenotypes characterized by mass cytometry.

Published
2021
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