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Your search keyword '"González, Alexis E."' showing total 7 results
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7 results on '"González, Alexis E."'

1. Negative Modulation of Macroautophagy by Stabilized HERPUD1 is Counteracted by an Increased ER-Lysosomal Network With Impact in Drug-Induced Stress Cell Survival

Author

Vargas, Gabriela, primary, Cortés, Omar, additional, Arias-Muñoz, Eloisa, additional, Hernández, Sergio, additional, Cerda-Troncoso, Cristobal, additional, Hernández, Laura, additional, González, Alexis E., additional, Tatham, Michael H., additional, Bustamante, Hianara A., additional, Retamal, Claudio, additional, Cancino, Jorge, additional, Varas-Godoy, Manuel, additional, Hay, Ronald T., additional, Rojas-Fernández, Alejandro, additional, Cavieres, Viviana A., additional, and Burgos, Patricia V., additional

Published
2022
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3. The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport

Author

Bustamante, Hianara A, primary, Cereceda, Karina, additional, González, Alexis E, additional, Valenzuela, Guillermo E, additional, Cheuquemilla, Yorka, additional, Hernández, Sergio, additional, Arias-Muñoz, Eloisa, additional, Cerda-Troncoso, Cristóbal, additional, Bandau, Susanne, additional, Soza, Andrea, additional, Kausel, Gudrun, additional, Kerr, Bredford, additional, Mardones, Gonzalo A, additional, Cancino, Jorge, additional, Hay, Ronald T, additional, Rojas-Fernandez, Alejandro, additional, and Burgos, Patricia V, additional

Published
2020
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4. The knocking down of the oncoprotein Golgi phosphoprotein 3 in T98G cells of glioblastoma multiforme disrupts cell migration by affecting focal adhesion dynamics in a focal adhesion kinase-dependent manner

Author

Lee, Jung Weon, Arriagada, Cecilia, Luchsinger, Charlotte, González, Alexis E., Schwenke, Tomás, Arriagada, Gloria, Folch, Hugo, Ehrenfeld, Pamela, Burgos, Patricia V., Mardones, Gonzalo A., Lee, Jung Weon, Arriagada, Cecilia, Luchsinger, Charlotte, González, Alexis E., Schwenke, Tomás, Arriagada, Gloria, Folch, Hugo, Ehrenfeld, Pamela, Burgos, Patricia V., and Mardones, Gonzalo A.

Abstract

Golgi phosphoprotein 3 (GOLPH3) is a conserved protein of the Golgi apparatus that in humans has been implicated in tumorigenesis. However, the precise function of GOLPH3 in malignant transformation is still unknown. Nevertheless, clinicopathological data shows that in more than a dozen kinds of cancer, including gliomas, GOLPH3 could be found overexpressed, which correlates with poor prognosis. Experimental data shows that overexpression of GOLPH3 leads to transformation of primary cells and to tumor growth enhancement. Conversely, the knocking down of GOLPH3 in GOLPH3-overexpressing tumor cells reduces tumorigenic features, such as cell proliferation and cell migration and invasion. The cumulative evidence indicate that GOLPH3 is an oncoprotein that promotes tumorigenicity by a mechanism that impact at different levels in different types of cells, including the sorting of Golgi glycosyltransferases, signaling pathways, and the actin cytoskeleton. How GOLPH3 connects mechanistically these processes has not been determined yet. Further studies are important to have a more complete understanding of the role of GOLPH3 as oncoprotein. Given the genetic diversity in cancer, a still outstanding aspect is how in this inherent heterogeneity GOLPH3 could possibly exert its oncogenic function. We have aimed to evaluate the contribution of GOLPH3 overexpression in the malignant phenotype of different types of tumor cells. Here, we analyzed the effect on cell migration that resulted from stable, RNAi-mediated knocking down of GOLPH3 in T98G cells of glioblastoma multiforme, a human glioma cell line with unique features. We found that the reduction of GOLPH3 levels produced dramatic changes in cell morphology, involving rearrangements of the actin cytoskeleton and reduction in the number and dynamics of focal adhesions. These effects correlated with decreased cell migration and invasion due to affected persistence and directionality of cell motility. Moreover, the knocking down

Published
2019

5. The knocking down of the oncoprotein Golgi phosphoprotein 3 in T98G cells of glioblastoma multiforme disrupts cell migration by affecting focal adhesion dynamics in a focal adhesion kinase-dependent manner

Author

Arriagada, Cecilia, primary, Luchsinger, Charlotte, additional, González, Alexis E., additional, Schwenke, Tomás, additional, Arriagada, Gloria, additional, Folch, Hugo, additional, Ehrenfeld, Pamela, additional, Burgos, Patricia V., additional, and Mardones, Gonzalo A., additional

Published
2019
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7. Autophagosomes cooperate in the degradation of intracellular C‐terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway

Author

González, Alexis E., primary, Muñoz, Vanessa C., additional, Cavieres, Viviana A., additional, Bustamante, Hianara A., additional, Cornejo, Víctor‐Hugo, additional, Januário, Yunan C., additional, González, Ibeth, additional, Hetz, Claudio, additional, Silva, Luis L., additional, Rojas‐Fernández, Alejandro, additional, Hay, Ronald T., additional, Mardones, Gonzalo A., additional, and Burgos, Patricia V., additional

Published
2017
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