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358 results on '"Gonthier R"'

29. Consensus sur la démence de type Alzheimer au stade sévère

Author

Vellas, B., Gauthier, S., Allain, H., Andrieu, S., Aquino, J.-P., Berrut, G., Berthel, M., Blanchard, F., Camus, V., Dartigues, J.-F., Dubois, B., Forette, F., Franco, A., Gonthier, R., Grand, A., Hervy, M.-P., Jeandel, C., Joel, M.-E., Jouanny, P., Lebert, F., Michot, P., Montastruc, J.-L., Nourhashemi, F., Ousset, P.-J., Pariente, J., Rigaud, A.-S., Robert, P., Ruault, G., Strubel, D., Touchon, J., Verny, M., and Vetel, J.-M.

Published
2005
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32. Rapid cognitive decline, one-year institutional admission and one-year mortality: Analysis of the ability to predict and inter-tool agreement of four validated clinical frailty indexes in the safes cohort

Author

Drame, M., Novella, J., Jolly, D., Laniece, I., Somme, D., Heitz, D., Gauvain, J., Voisin, T., De Wazieres, B., Gonthier, R., Jeandel, C., Couturier, P., Saint-Jean, O., Ankri, J., Blanchard, F., Lang, Pierre, Drame, M., Novella, J., Jolly, D., Laniece, I., Somme, D., Heitz, D., Gauvain, J., Voisin, T., De Wazieres, B., Gonthier, R., Jeandel, C., Couturier, P., Saint-Jean, O., Ankri, J., Blanchard, F., and Lang, Pierre

Abstract

Objectives: To evaluate the predictive ability of four clinical frailty indexes as regards one-year rapid cognitive decline (RCD — defined as the loss of at least 3 points on the MMSE score), and one-year institutional admission (IA) and mortality respectively; and to measure their agreement for identifying groups at risk of these severe outcomes. Design: One-year follow-up and multicentre study of old patients participating in the SAFEs cohort study. Setting: Nine university hospitals in France. Participants: 1,306 patients aged 75 or older (mean age 85±6 years; 65% female) hospitalized in medical divisions through an Emergency department. Measurements: Four frailty indexes (Winograd; Rockwood; Donini; and Schoevaerdts) reflecting the multidimensionality of the frailty concept, using an ordinal scoring system able to discriminate different grades of frailty, and constructed based on the accumulation of identified deficits after comprehensive geriatric assessment conducted during the first week of hospital stay, were used to categorize participants into three different grades of frailty: Gl — not frail; G2 — moderately frail; and G3 — severely frail. Comparisons between groups were performed using Fisher's exact test. Agreement between indexes was evaluated using Cohen's Kappa coefficient. Results: All patients were classified as frail by at least one of the four indexes. The Winograd and Rockwood indexes mainly classified subjects as G2 (85% and 96%), and the Donini and Schoevaerdts indexes mainly as G3 (71% and 67%). Among the SAFEs cohort population, 250, 1047 and 1,306 subjects were eligible for analyses of predictability for RCD, 1-year IA and 1-year mortality respectively. At 1 year, 84 subjects (34%) experienced RCD, 377 (36%) were admitted into an institutional setting, and 445 (34%) had died With the Rockwood index, all subjects who expenenced RCD were classified in G2; and in G2 and G3 when the Donini and Schoevaerdts indexes were used No significant diffe

Published
2018

39. Cancer de prostate des sujets âgés : place et rôle de l’évaluation gériatrique

Author

Méry, B., primary, Vallard, A., additional, Espenel, S., additional, Badie, N., additional, Thiermant, M., additional, Lambert, V., additional, Soulier, V., additional, Piqueres, S., additional, Del Santo, K., additional, Ben Mrad, M., additional, Wang, G., additional, Diao, P., additional, Langrand-Escure, J., additional, Rivoirard, R., additional, Guy, J.-B., additional, Guillot, A., additional, Chanelière, A.-F., additional, Gonthier, R., additional, Achour, E., additional, Fournel, P., additional, and Magné, N., additional

Published
2016
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40. General management of nonagenarian patients: a review of the literature

Author

Rivoirard, R, primary, Chargari, C, additional, Trone, JC, additional, Falk, A, additional, Guy, JB, additional, Eddekaoui, H, additional, Lahmar, R, additional, Pacaut, C, additional, Mery, B, additional, Assouline, A, additional, Auberdiac, P, additional, Moriceau, G, additional, Gonthier, R, additional, Guillot, A, additional, Merrouche, Y, additional, and Magné, N, additional

Published
2014
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41. IANA (International Academy on Nutrition and Aging) Expert Group: weight loss and Alzheimer's disease

Author

Gillette-Guyonnet, S., Abellan Kan, G., Alix, E., Andrieu, S., Belmin, J., Berrut, G., Bonnefoy, M., Brocker, P., Constans, T., Ferry, M., Ghisolfi-Marque, A., Girard, L., Gonthier, R., Guerin, O., Hervy, M. -P, Jouanny, P., Laurain, M. -C, Lechowski, L., Nourhashemi, F., Raynaud-Simon, A., Ritz, P., jean Roche, Rolland, Y., Salva, T., and Vellas, B.

Subjects
Cerebral Cortex, Alzheimer Disease, Weight Loss, Humans, Nutritional Status, Nutritional Physiological Phenomena, Energy Metabolism
Abstract

Weight loss, together with psychological and behavioural symptoms and problems of mobility, is one of the principal manifestations of Alzheimer's disease (AD). Weight loss may be associated with protein and energy malnutrition leading to severe complications (alteration of the immune system, muscular atrophy, loss of independence). Various explanations have been proposed such as atrophy of the mesial temporal cortex, biological disturbances, or feeding behaviours; however, none has been proven. Prevention of weight loss in AD is a major issue. It requires regular follow-up and must be an integral part of the care plan. The aim of this article is to review the present state of scientific knowledge on weight loss associated with AD. We will consider four points: the natural history of weight loss, its known etiological factors, its consequences and the various management options.

Published
2007

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