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202 results on '"Gonnin A."'

1. CD57+ EMRA CD8+ T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy

Author

Gonnin, Cécile, Leemans, Michelle, Canoui-Poitrine, Florence, Lebraud, Morgane, Corneau, Aurélien, Roquebert, Louise, Caillet, Philippe, Gay, Pierre, Canovas, Johanna, Histe, Axelle, Blanc, Catherine, El-Sissy, Carine, Larbi, Anis, Poisson, Johanne, Ober, Pauline, Boudou-Rouquette, Pascaline, Natella, Pierre-André, Vallet, Hélène, Saadaoui, Besma, Layese, Richard, Tartour, Eric, Paillaud, Elena, and Granier, Clémence

Published
2024
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2. Increased levels of GM-CSF and CXCL10 and low CD8+ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people

Author

Poisson, Johanne, El-Sissy, Carine, Serret-Larmande, Arnaud, Smith, Nikaïa, Lebraud, Morgane, Augy, Jean-Loup, Conti, Catherine, Gonnin, Cécile, Planquette, Benjamin, Arlet, Jean-Benoît, Hermann, Bertrand, Charbit, Bruno, Pastre, Jean, Devaux, Floriane, Ladavière, Cyrielle, Lim, Lydie, Ober, Pauline, Cannovas, Johanna, Biard, Lucie, Gulczynski, Marie-Christelle, Blumenthal, Noémie, Péré, Hélène, Knosp, Camille, Gey, Alain, Benhamouda, Nadine, Murris, Juliette, Veyer, David, Tartour, Eric, Diehl, Jean-Luc, Duffy, Darragh, Paillaud, Elena, and Granier, Clémence

Published
2024
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4. Two-chamber gas target for laser-plasma accelerator electron source

Author

Drobniak, P., Baynard, E., Cassou, K., Douillet, D., Demailly, J., Gonnin, A., Iaquaniello, G., Kane, G., Kazamias, S., Lericheux, N., Lucas, B., Mercier, B., Peinaud, Y., and Pittman, M.

Subjects
Physics - Accelerator Physics, Physics - Fluid Dynamics, Physics - Plasma Physics
Abstract

Exploring new target schemes for laser wakefield accelerators is essential to meet the challenge of increasing repetition rates while ensuring stability and quality of the produced electron beams. The prototyping of a two-chamber gas cell integrated into the beam line and operating in continuous gas flow is introduced and discussed in the frame of ionisation injection. We report the numerical fluid modeling used to assist the density profile shaping. We describe the test bench used for cell prototype assessment, in particular the plasma electron density and longitudinal distribution of species relevant for ionisation injection. The lifetime of the target key part is measured for different materials. Perspectives to high power operation are outlined.

Published
2023

5. Commissioning of ThomX Compton source subsystems and demonstration of 10^{10} x-rays/s

Author

Muath Alkadi, Manuel Alves, Manar Amer, Loic Amoudry, Didier Auguste, Jean-Luc Babigeon, Michel Baltazar, Alain Benoit, Alexandre Blin, Marco Bonanzingamarco, Jean Bonenfant, Julien Bonis, Jean-Pierre Brasile, Kevin Cassou, Jean-Noël Cayla, Thomas Chabaud, Iryna Chaikovska, Sophie Chance, Vincent Chaumat, Ronic Chiche, Patrick Cornebise, Olivier Dalifard, Nicolas Delerue, Remy Dorkel, Denis Douillet, Illya Drebot, Jean-Phillipe Dugal, Kevin Dupraz, Noureddine El Kamchi, Mohamed El Khaldi, Ezgi Ergenlik, Pierre Favier, Marco Fernandez, Alexis Gamelin, Jean-Francois Garaut, Luca Garolfi, Philippe Gauron, Frédéric Gauthier, Alexandre Gonnin, Denis Grasset, Eric Guerard, Hayg Guler, Jacques Haissinski, Emmanuel Herry, Gregory Iaquaniello, Marie Jacquet, Didier Jehanno, Eric Jules, Viacheslav Kubytskyi, François Labaye, Mickaël Lacroix, Marc Langlet, Titouan Lebarillec, Jean-François Ledu, Damien Le Guidec, Bruno Leluan, Pierre Lepercq, Frédéric Letellier-cohen, Rodolphe Marie, Jean-Claude Marrucho, Aurélien Martens, Christophe Mageur, Gabriel Mercadier, Bruno Mercier, Eric Mistretta, Hugues Monard, Alexandre Moutardier, Viktor Mytrochenko, Olivier Neveu, Daniele Nutarelli, Maher Omeich, Yann Peinaud, Antoine Pérus, Yannick Petrilli, Marc Pichet, Bernard Pieyre, Eric Plaige, Christophe Prévost, Thomas Roulet, Raphael Roux, Philippe Rudnicky, Viktor Soskov, Monique Taurigna-Quéré, Stéphane Trochet, Cynthia Vallerand, Alessandro Variola, Olivier Vitez, François Wicek, Guy Wormser, Sébastien Wurth, Fabian Zomer, Patrick Alexandre, Rachid Ben el Fekih, Philippe Berteaud, Sébastien Bobault, Yazid Bouanani, François Bouvet, Lodovico Cassinari, Marie-Emmanuelle Couprie, Renaud Cuoq, Helder Dias, Yannick Dietrich, Massamba Diop, Eric Dupuy, Moussa El Ajjouri, Christian Herbeaux, Nicolas Hubert, Marie Labat, Alain Lestrade, Antoine Letrésor, Robert Lopes, Alexandre Loulergue, Patrick Marchand, Fabrice Marteau, Didier Muller, Amor Nadji, Laurent Nadolski, Ryutaro Nagaoka, Dominique Pedeau, Sylvain Petit, Jean Pierre Pollina, Fernand Ribeiro, Manuel Ros, Julien Salvia, Mourad Sebdaoui, Rajesh Sreedharan, Jean Susini, José Veteran, Cyril Bruyere, Alain Cobessi, William Del Net, Jean-Louis Hazemann, Jean-Louis Hodeau, Philippe Jacquet, Philippe Jeantet, Grigor Kapoujyan, Jérôme Lacipière, Eric Lahéra, Gilles Perroux, Olivier Proux, Emmanuel Roy, Philippe Walter, Alberto Bravin, Hélène Elleaume, François Estève, Harold Bzyl, Christophe Chapelle, Jean-Michel Horodynski, Pierre Robert, Eric Cormier, Jérôme Degallaix, Christophe Michel, Laurent Pinard, Philippe Balcou, Jérôme Lhermite, Sébastien Montant, Marie-Christine Nadeau, Stéphane Petit, Nikolay Artemiev, Marica Biagini, Romain Czarny, Pascal Girault, Sophie Muller, Serge Sierra, Christophe Simon-Boisson, Said Bouaziz, Chamseddine Benabderrahmane, Géraldine Le Duc, and Xing Liu

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

ThomX is a compact x-ray source based on Compton scattering, installed at IJCLab (Laboratoire de physique des 2 infinis-Irène Joliot-Curie) in Orsay. The machine uses a small electron storage ring and an intense laser pulse stored in a high-finesse optical cavity. This article describes the various subsystems of the machine and their initial results of the commissioning, which began in mid-2021. This first commissioning phase led to the production of 10^{10} x-rays/s with an on-axis energy of 45 keV. The main steps to be taken to reach the nominal flux are outlined at the end.

Published
2025
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6. First production of X-rays at the ThomX high-intensity Compton source

Author

Jacquet, Marie, Alexandre, Patrick, Alkadi, Muath, Alves, Manuel, Amer, Manar, Amoudry, Loic, Auguste, Didier, Babigeon, Jean-Luc, Balcou, Philippe, Baltazar, Michel, Benabderrahmane, Chamseddine, el Fekih, Rachid Ben, Benoit, Alain, Berteaud, Philippe, Biagini, Marica, Blin, Alexandre, Bobault, Sébastien, Bonanzingamarco, Marco, Bonenfant, Jean, Bonis, Julien, Bouanani, Yazid, Bouaziz, Said, Bouvet, François, Bravin, Alberto, Bruni, Christelle, Bruyere, Cyril, Bzyl, Harold, Cassinari, Lodovico, Cassou, Kevin, Cayla, Jean-Noël, Chabaud, Thomas, Chaikovska, Iryna, Chance, Sophie, Chapelle, Christophe, Chaumat, Vincent, Chiche, Ronic, Cobessi, Alain, Cormier, Eric, Cornebise, Patrick, Couprie, Marie-Emmanuelle, Cuoq, Renaud, Dalifard, Olivier, Degallaix, Jérôme, Delerue, Nicolas, Del Net, William, Diaz, Antonio, Dietrich, Yannick, Diop, Massamba, Dorkel, Remy, Douillet, Denis, Drebot, Illya, Dugal, Jean-Phillipe, Dupraz, Kevin, Dupuy, Eric, El Ajjouri, Moussa, El Kamchi, Noureddine, El Khaldi, Mohamed, Elleaume, Hélène, Ergenlik, Ezgi, Estève, François, Favier, Pierre, Fernandez, Marco, Gamelin, Alexis, Garaut, Jean-François, Garolfi, Luca, Gauron, Philippe, Gauthier, Frédéric, Girault, Pascal, Gonnin, Alexandre, Grasset, Denis, Guerard, Eric, Guler, Hayg, Haissinski, Jacques, Hazemann, Jean-Louis, Helder, Dias, Herbeaux, Christian, Herry, Emmanuel, Hodeau, Jean-Louis, Horodynski, Jean-Michel, Hubert, Nicolas, Iaquaniello, Gregory, Jacquet, Philippe, Jeantet, Philippe, Jehanno, Didier, Jules, Eric, Kapoujyan, Grigor, Kubytskyi, Viacheslav, Labat, Marie, Labaye, François, Lacipière, Jerome, Lacroix, Mickaël, Lahéra, Eric, Langlet, Marc, Lebarillec, Titouan, Ledu, Jean-François, Le Duc, Géraldine, Le Guidec, Damien, Leluan, Bruno, Lepercq, Pierre, Lestrade, Alain, Letellier-cohen, Frédéric, Letrésor, Antoine, Lhermite, Jérôme, Liu, Xing, Lopes, Robert, Loulergue, Alexandre, Louvet, Marc, Mageur, Christophe, Marchand, Patrick, Marie, Rodolphe, Marrucho, Jean-Claude, Marteau, Fabrice, Martens, Aurélien, Mercadier, Gabriel, Mercier, Bruno, Michel, Christophe, Mistretta, Eric, Monard, Hugues, Moutardier, Alexandre, Muller, Didier, Nadji, Amor, Nadolski, Laurent, Nagaoka, Ryutaro, Neveu, Olivier, Nutarelli, Daniele, Omeich, Maher, Pedeau, Dominique, Peinaud, Yann, Perroux, Gilles, Pérus, Antoine, Petit, Sylvain, Petrilli, Yannick, Pichet, Marc, Pieyre, Bernard, Pinard, Laurent, Plaige, Eric, Pollina, Jean Pierre, Prévost, Christophe, Proux, Olivier, Ribeiro, Fernand, Robert, Pierre, Ros, Manuel, Roulet, Thomas, Roux, Raphael, Roy, Emmanuel, Rudnicky, Philippe, Salvia, Julien, Sebdaoui, Mourad, Sierra, Serge, Soskov, Viktor, Sreedharan, Rajesh, Susini, Jean, Taurigna-Quéré, Monique, Trochet, Stéphane, Vallerand, Cynthia, Variola, Alessandro, Veteran, José, Vitez, Olivier, Walter, Philippe, Wicek, François, Wurth, Sébastien, and Zomer, Fabian

Published
2024
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7. Structural landscape of the respiratory syncytial virus nucleocapsids

Author

Lorène Gonnin, Ambroise Desfosses, Maria Bacia-Verloop, Didier Chevret, Marie Galloux, Jean-François Éléouët, and Irina Gutsche

Subjects
Science
Abstract

Abstract Human Respiratory Syncytial Virus (HRSV) is a prevalent cause of severe respiratory infections in children and the elderly. The helical HRSV nucleocapsid is a template for the viral RNA synthesis and a scaffold for the virion assembly. This cryo-electron microscopy analysis reveals the non-canonical arrangement of the HRSV nucleocapsid helix, composed of 16 nucleoproteins per asymmetric unit, and the resulting systematic variations in the RNA accessibility. We demonstrate that this unique helical symmetry originates from longitudinal interactions by the C-terminal arm of the HRSV nucleoprotein. We explore the polymorphism of the nucleocapsid-like assemblies, report five structures of the full-length particles and two alternative arrangements formed by a C-terminally truncated nucleoprotein mutant, and demonstrate the functional importance of the identified longitudinal interfaces. We put all these findings in the context of the HRSV RNA synthesis machinery and delineate the structural basis for its further investigation.

Published
2023
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8. Preexisting autoantibodies as predictor of immune related adverse events (irAEs) for advanced solid tumors treated with immune checkpoint inhibitors (ICIs)

Author

A Daban, C Gonnin, L Phan, A Saldmann, C Granier, A Lillo-Lelouet, C Le Beller, J Pouchot, l Weiss, E Tartour, E Fabre, J Medioni, S Oudard, YA Vano, MA Dragon-Durey, and A. Simonaggio

Subjects
Immune checkpoint inhibitors, immune-related adverse events, pre-existing antibodies, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Introduction: Immune checkpoint inhibitors (ICIs) are now standard of care in many cancers. They can generate immune-related adverse events (irAEs), but no biomarkers are available to identify patients who are more likely to develop irAEs. We assess the association between pre-existing autoantibodies and occurrence of irAEs. Patients and Methods: We prospectively collected data from consecutive patients receiving ICIs for advanced cancers, in a single center between May 2015 and July 2021. Autoantibodies testing was performed before ICIs initiation including AntiNeutrophil Cytoplasmic Antibodies, Antinuclear Antibodies, Rheumatoid Factor anti-Thyroid Peroxidase and anti-Thyroglobulin. We analyzed the associations of pre-existing autoantibodies with onset, severity, time to irAEs and with survival outcomes. Results: Of the 221 patients included, most had renal cell carcinoma (n = 99; 45%) or lung carcinoma (n = 90; 41%). Grade ≥2 irAEs were more frequent among patients with pre-existing autoantibodies: 64 (50%) vs. 20 (22%) patients (Odds-Ratio= 3.5 [95% CI=1.8-6.8]; p < 0.001) in the positive vs negative group, respectively. irAEs occurred earlier in the positive group with a median time interval between ICI initiation and irAE of 13 weeks (IQR = 8.8-21.6) vs. 28.5 weeks (IQR=10.6-55.1) in the negative group (p = 0.01). Twelve patients (9.4%) experienced multiple (≥2) irAEs in the positive group vs. 2 (2%) in the negative group (OR = 4.5 [95% CI: 0.98-36], p = 0.04). After a median follow-up of 25 months, median PFS and OS were significantly longer among patients experiencing irAE (p = 0.00034 and p = 0.016, respectively). Conclusion: The presence of pre-existing autoantibodies is significantly associated with the occurrence of grade ≥2 irAEs, with earlier and multiple irAEs in patients treated with ICIs.

Published
2023
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9. Intestinal Candida albicans overgrowth in IgA deficiency

Author

Moreno-Sabater, Alicia, Sterlin, Delphine, Imamovic, Lejla, Bon, Fabienne, Normand, Anne-Cecile, Gonnin, Cecile, Gazzano, Marianne, Bensalah, Merieme, Dorgham, Karim, Ben Salah, Elyes, Acherar, Aniss, Parizot, Christophe, Rigourd, Virginie, Begue, Hervé, Dalle, Frederic, Bachmeyer, Claude, Hennequin, Christophe, Yssel, Hans, Malphettes, Marion, Fieschi, Claire, Fadlallah, Jehane, and Gorochov, Guy

Published
2023
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11. First production of X-rays at the ThomX high-intensity Compton source

Author

Jacquet, M, Alexandre, P, Alkadi, M, Alves, M, Amer, M, Amoudry, L, Auguste, D, Babigeon, J, Balcou, P, Baltazar, M, Benabderrahmane, C, el Fekih, R, Benoit, A, Berteaud, P, Biagini, M, Blin, A, Bobault, S, Bonanzingamarco, M, Bonenfant, J, Bonis, J, Bouanani, Y, Bouaziz, S, Bouvet, F, Bravin, A, Bruni, C, Bruyere, C, Bzyl, H, Cassinari, L, Cassou, K, Cayla, J, Chabaud, T, Chaikovska, I, Chance, S, Chapelle, C, Chaumat, V, Chiche, R, Cobessi, A, Cormier, E, Cornebise, P, Couprie, M, Cuoq, R, Dalifard, O, Degallaix, J, Delerue, N, Del Net, W, Diaz, A, Dietrich, Y, Diop, M, Dorkel, R, Douillet, D, Drebot, I, Dugal, J, Dupraz, K, Dupuy, E, El Ajjouri, M, El Kamchi, N, El Khaldi, M, Elleaume, H, Ergenlik, E, Estève, F, Favier, P, Fernandez, M, Gamelin, A, Garaut, J, Garolfi, L, Gauron, P, Gauthier, F, Girault, P, Gonnin, A, Grasset, D, Guerard, E, Guler, H, Haissinski, J, Hazemann, J, Helder, D, Herbeaux, C, Herry, E, Hodeau, J, Horodynski, J, Hubert, N, Iaquaniello, G, Jacquet, P, Jeantet, P, Jehanno, D, Jules, E, Kapoujyan, G, Kubytskyi, V, Labat, M, Labaye, F, Lacipière, J, Lacroix, M, Lahéra, E, Langlet, M, Lebarillec, T, Ledu, J, Le Duc, G, Le Guidec, D, Leluan, B, Lepercq, P, Lestrade, A, Jacquet M., Alexandre P., Alkadi M., Alves M., Amer M., Amoudry L., Auguste D., Babigeon J. L., Balcou P., Baltazar M., Benabderrahmane C., el Fekih R. B., Benoit A., Berteaud P., Biagini M., Blin A., Bobault S., Bonanzingamarco M., Bonenfant J., Bonis J., Bouanani Y., Bouaziz S., Bouvet F., Bravin A., Bruni C., Bruyere C., Bzyl H., Cassinari L., Cassou K., Cayla J. N., Chabaud T., Chaikovska I., Chance S., Chapelle C., Chaumat V., Chiche R., Cobessi A., Cormier E., Cornebise P., Couprie M. E., Cuoq R., Dalifard O., Degallaix J., Delerue N., Del Net W., Diaz A., Dietrich Y., Diop M., Dorkel R., Douillet D., Drebot I., Dugal J. P., Dupraz K., Dupuy E., El Ajjouri M., El Kamchi N., El Khaldi M., Elleaume H., Ergenlik E., Estève F., Favier P., Fernandez M., Gamelin A., Garaut J. F., Garolfi L., Gauron P., Gauthier F., Girault P., Gonnin A., Grasset D., Guerard E., Guler H., Haissinski J., Hazemann J. L., Helder D., Herbeaux C., Herry E., Hodeau J. L., Horodynski J. M., Hubert N., Iaquaniello G., Jacquet P., Jeantet P., Jehanno D., Jules E., Kapoujyan G., Kubytskyi V., Labat M., Labaye F., Lacipière J., Lacroix M., Lahéra E., Langlet M., Lebarillec T., Ledu J. F., Le Duc G., Le Guidec D., Leluan B., Lepercq P., Lestrade A., Jacquet, M, Alexandre, P, Alkadi, M, Alves, M, Amer, M, Amoudry, L, Auguste, D, Babigeon, J, Balcou, P, Baltazar, M, Benabderrahmane, C, el Fekih, R, Benoit, A, Berteaud, P, Biagini, M, Blin, A, Bobault, S, Bonanzingamarco, M, Bonenfant, J, Bonis, J, Bouanani, Y, Bouaziz, S, Bouvet, F, Bravin, A, Bruni, C, Bruyere, C, Bzyl, H, Cassinari, L, Cassou, K, Cayla, J, Chabaud, T, Chaikovska, I, Chance, S, Chapelle, C, Chaumat, V, Chiche, R, Cobessi, A, Cormier, E, Cornebise, P, Couprie, M, Cuoq, R, Dalifard, O, Degallaix, J, Delerue, N, Del Net, W, Diaz, A, Dietrich, Y, Diop, M, Dorkel, R, Douillet, D, Drebot, I, Dugal, J, Dupraz, K, Dupuy, E, El Ajjouri, M, El Kamchi, N, El Khaldi, M, Elleaume, H, Ergenlik, E, Estève, F, Favier, P, Fernandez, M, Gamelin, A, Garaut, J, Garolfi, L, Gauron, P, Gauthier, F, Girault, P, Gonnin, A, Grasset, D, Guerard, E, Guler, H, Haissinski, J, Hazemann, J, Helder, D, Herbeaux, C, Herry, E, Hodeau, J, Horodynski, J, Hubert, N, Iaquaniello, G, Jacquet, P, Jeantet, P, Jehanno, D, Jules, E, Kapoujyan, G, Kubytskyi, V, Labat, M, Labaye, F, Lacipière, J, Lacroix, M, Lahéra, E, Langlet, M, Lebarillec, T, Ledu, J, Le Duc, G, Le Guidec, D, Leluan, B, Lepercq, P, Lestrade, A, Jacquet M., Alexandre P., Alkadi M., Alves M., Amer M., Amoudry L., Auguste D., Babigeon J. L., Balcou P., Baltazar M., Benabderrahmane C., el Fekih R. B., Benoit A., Berteaud P., Biagini M., Blin A., Bobault S., Bonanzingamarco M., Bonenfant J., Bonis J., Bouanani Y., Bouaziz S., Bouvet F., Bravin A., Bruni C., Bruyere C., Bzyl H., Cassinari L., Cassou K., Cayla J. N., Chabaud T., Chaikovska I., Chance S., Chapelle C., Chaumat V., Chiche R., Cobessi A., Cormier E., Cornebise P., Couprie M. E., Cuoq R., Dalifard O., Degallaix J., Delerue N., Del Net W., Diaz A., Dietrich Y., Diop M., Dorkel R., Douillet D., Drebot I., Dugal J. P., Dupraz K., Dupuy E., El Ajjouri M., El Kamchi N., El Khaldi M., Elleaume H., Ergenlik E., Estève F., Favier P., Fernandez M., Gamelin A., Garaut J. F., Garolfi L., Gauron P., Gauthier F., Girault P., Gonnin A., Grasset D., Guerard E., Guler H., Haissinski J., Hazemann J. L., Helder D., Herbeaux C., Herry E., Hodeau J. L., Horodynski J. M., Hubert N., Iaquaniello G., Jacquet P., Jeantet P., Jehanno D., Jules E., Kapoujyan G., Kubytskyi V., Labat M., Labaye F., Lacipière J., Lacroix M., Lahéra E., Langlet M., Lebarillec T., Ledu J. F., Le Duc G., Le Guidec D., Leluan B., Lepercq P., and Lestrade A.

Abstract

With the increase in laser power and finesse of optical cavities over the last decade, laboratory-size Compton sources are very promising. These sources produce X-rays through interactions between relativistic electrons and laser photons and, in term of brightness, fall between large synchrotron facilities and classical laboratory X-ray sources. The ThomX source is the French project in this field. This article first presents a state of the art of high-intensity Compton sources, then the ThomX source is briefly described, and the first results are detailed, in particular the production of the first X-rays, the acquisition of the first spectrum and the first image of the beam. Finally, the next objectives are discussed.

Published
2024

12. CD57+ EMRA CD8+ T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy.

Author

Gonnin, Cécile, Leemans, Michelle, Canoui-Poitrine, Florence, Lebraud, Morgane, Corneau, Aurélien, Roquebert, Louise, Caillet, Philippe, Gay, Pierre, Canovas, Johanna, Histe, Axelle, Blanc, Catherine, El-Sissy, Carine, Larbi, Anis, Poisson, Johanne, Ober, Pauline, Boudou-Rouquette, Pascaline, Natella, Pierre-André, Vallet, Hélène, Saadaoui, Besma, and Layese, Richard

Subjects
T-cell exhaustion, OLDER people, MEDICAL sciences, T cells, OLDER patients
Abstract

Background: Immune ageing complicates cancer treatment in older individuals. While immunotherapy targeting the PD-1/PD-L1 pathway can reinvigorate T cells, these cells tend to become senescent with age. This study investigates different CD8+ T cell subsets usually associated with senescence, in cancer patients over 70 years old who are undergoing anti-PD-1/PD-L1 immunotherapy, and examines the relationship between these senescent cells and prior chemotherapy exposure. We analyzed data from the Elderly Cancer Patient (ELCAPA) cohort, which included 35 patients enrolled between March 2018 and March 2021. Results: Flow cytometry and unsupervised analysis were employed to characterize Effector Memory CD45RA+ (EMRA) and CD8+ T cell senescence at baseline, before initiating PD-1/PD-L1 therapy. EMRA cells were found to overexpress CD57 and KLRG1 compared to overall CD8+ T cells. Chemotherapy prior to anti-PD-1/PD-L1 was associated with an increased proportion of CD57+ EMRA CD8+ T cells (p = 0.009) and its granzyme B (GRZB) subset (p = 0.007). Using a 10% cut-off to define positivity, the six-month non-response tends to be associated with the CD57+ GRZB+ EMRA positivity (p = 0.097). Other CD8+ T cell subsets (EMRA, CD57+, or KLRG1+), usually associated with senescence, showed no significant association with previous chemotherapy or response to anti-PD-1/anti-PD-L1 therapy. Conclusions: These findings underscore the impact of prior chemotherapy on expanding the pool of senescent T cells, particularly CD57+ EMRA CD8+ T and CD57+ GRZB+ EMRA CD8+ T cells, whose expansion could potentially affect the effectiveness of anti-PD-1/PD-L1 immunotherapy in elderly patients. This highlights the need for tailored approaches in this population. [ABSTRACT FROM AUTHOR]

Published
2024
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17. The ThomX ICS source

Author

Dupraz, Kevin, Alkadi, Muath, Alves, Manuel, Amoudry, Loic, Auguste, Didier, Babigeon, Jean-Luc, Baltazar, Michel, Benoit, Alain, Bonis, Julien, Bonenfant, Jean, Bruni, Christelle, Cassou, Kevin, Cayla, Jean-Noël, Chabaud, Thomas, Chaikovska, Iryna, Chance, Sophie, Chaumat, Vincent, Chiche, Ronic, Cobessi, Alain, Cornebise, Patrick, Dalifard, Olivier, Delerue, Nicolas, Dorkel, Remy, Douillet, Denis, Dugal, Jean-Phillipe, El Kamchi, Noureddine, El Khaldi, Mohamed, Ergenlik, Ezgi, Favier, Pierre, Fernandez, Marco, Gamelin, Alexis, Garaut, Jean-Francois, Garolfi, Luca, Gauron, Philippe, Gauthier, Frédéric, Gonnin, Alexandre, Grasset, Denis, Guerard, Eric, Guler, Hayg, Haissinski, Jacques, Herry, Emmanuel, Iaquaniello, Gregory, Jacquet, Marie, Jules, Eric, Kubytskyi, Vlacheslav, Langlet, Marc, Le Barillec, Titouan, Ledu, Jean-François, Leguidec, Damien, Leluan, Bruno, Lepercq, Pierre, Letellier-Cohen, Frédéric, Marie, Rodolphe, Marrucho, Jean-Claude, Martens, Aurélien, Mageur, Christophe, Mercadier, Gabriel, Mercier, Bruno, Mistretta, Eric, Monard, Hugues, Moutardier, Alexandre, Neveu, Olivier, Nutarelli, Daniele, Omeich, Maher, Peinaud, Yann, Petrilli, Yann, Pichet, Marc, Plaige, Eric, Prévost, Christophe, Rudnicky, Philippe, Soskov, Viktor, Taurigna-Quéré, Monique, Trochet, Stéphane, Vallerand, Cynthia, Vitez, Olivier, Wicek, François, Wurth, Sébastien, Zomer, Fabian, Alexandre, Patrick, Ben El Fekih, Rachid, Berteaud, Philippe, Bouvet, François, Cuoq, Renaud, Diaz, Antonio, Dietrich, Yannick, Diop, Massamba, Pedeau, Dominique, Dupuy, Eric, Marteau, Fabrice, Helder, Dias, Hubert, Nicolas, Veteran, José, Labat, Marie, Lestrade, Alain, Letrésor, Antoine, Lopes, Robert, Loulergue, Alexandre, Louvet, Marc, Marchand, Patrick, El Ajjouri, Moussa, Muller, Didier, Nadji, Amor, Nadolski, Laurent, Nagaoka, Ryutaro, Petit, Sylvain, Pollina, Jean-Pierre, Ribeiro, Fernand, Ros, Manuel, Salvia, Julien, Bobault, Sébastien, Sebdaoui, Mourad, Sreedharan, Rajesh, Bouanai, Yazid, Hazemann, Jean-Louis, Hodeau, Jean-Louis, Roy, Emmanuel, Jeantet, Philippe, Lacipière, Jérôme, Robert, Pierre, Horodynski, Jean-Michel, Bzyl, Harold, Chapelle, Christophe, Biagini, Marica, Walter, Philippe, Bravin, Alberto, Del Net, William, Lahéra, Eric, Proux, Olivier, Elleaume, Hélène, and Cormier, Eric

Published
2020
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18. White blood cells scattergram as a valuable tool for COVID‐19 screening: A multicentric study

Author

Osman, Jennifer, primary, Gonnin, Cécile, additional, Lambert, Jérome, additional, Behier, Céline, additional, Chapuis, Nicolas, additional, Chevalier, Simon, additional, Debus, Jérôme, additional, Delaval, Anne, additional, Depoorter, Maxime, additional, Dumas, Cécile, additional, Dumesges, Amély, additional, Dussert, Pascale, additional, Vacher, Corinne Ferrero, additional, Dubois‐Galopin, Frédérique, additional, Gerard, Delphine, additional, Bollotte, Pauline Gravière, additional, Guignedoux, Geoffroy, additional, Mayeur‐Rousse, Caroline, additional, Mercier‐Bataille, Delphine, additional, Ronez, Emily, additional, Trichet, Catherine, additional, Wiber, Margaux, additional, and Raggueneau, Victoria, additional

Published
2024
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19. Random error propagation on electron beam dynamics for a 50 MeV S-band linac

Author

H Purwar, E Goutierre, H Guler, M Rossetti Conti, S Chance, A Gonnin, H Monard, A Bacci, M Sebag, J Cohen, and C Bruni

Subjects
electron beam dynamics, random error propagation, photoinjector, Science, Physics, QC1-999
Abstract

The stability and the quality of particle beams are of utmost importance for many emerging linac installations. The impact on beam properties damage of beam electromagnetic element misalignments and jitter/fluctuations in various accelerator sub-systems should be properly known, as usually such shot-to-shot fluctuations cannot be avoided. On top of that, knowing which parameters the machine is most sensitive to is of utmost to take precautionary measures to reduce the beam degradation and thus improve beam stability and quality. This simulation work focuses on a 50 MeV S-band linear accelerator based on RF photoinjector electron source. The sensitivity of the beam parameters towards several errors has been studied collectively as well as individually for each accelerator element. While the emittance at the end of the linac is dominated by the laminar behavior in the accelerating section, the main emittance degradation comes mainly from orbit errors located at the linac entrance.

Published
2023
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20. PHIL photoinjector test line

Author

Alves, M., Arnault, C., Auguste, D., Babigeon, J. L., Blot, F., Brossard, J., Bruni, C., Cavalier, S., Cayla, J. N., Chaumat, V., Collin, J., Dehamme, M., Demarest, M., Dugal, J. P., Elkhaldi, M., Falleau, I., Gonnin, A., Jore, M., Jules, E., Leluan, B., Lepercq, P., Letellier, F., Mandag, E., Marrucho, J. C., Mercier, B., Mistretta, E., Prevost, C., Roux, R., Soskov, V., Toutain, A., Variola, A., Vitez, O, and Monard, H.

Subjects
Physics - Accelerator Physics, Physics - Instrumentation and Detectors
Abstract

LAL is now equiped with its own platform for photoinjectors tests and Research and Developement, named PHIL (PHotoInjectors at LAL). This facility has two main purposes: push the limits of the photoinjectors performances working on both the design and the associated technology and provide a low energy (MeV) short pulses (ps) electron beam for the interested users. Another very important goal of this machine will be to provide an opportunity to form accelerator physics students, working in a high technology environment. To achieve this goal a test line was realised equipped with an RF source, magnets and beam diagnostics. In this article we will desrcibe the PHIL beamline and its characteristics together with the description of the first two photoinjector realised in LAL and tested: the ALPHAX and the PHIN RF Guns.

Published
2012
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25. Interactions between the Nucleoprotein and the Phosphoprotein of Pneumoviruses: Structural Insight for Rational Design of Antivirals

Author

Hortense Decool, Lorène Gonnin, Irina Gutsche, Christina Sizun, Jean-François Eléouët, and Marie Galloux

Subjects
pneumoviruses, RSV, HMPV, nucleoprotein, phosphoprotein, protein-protein interaction, Microbiology, QR1-502
Abstract

Pneumoviruses include pathogenic human and animal viruses, the most known and studied being the human respiratory syncytial virus (hRSV) and the metapneumovirus (hMPV), which are the major cause of severe acute respiratory tract illness in young children worldwide, and main pathogens infecting elderly and immune-compromised people. The transcription and replication of these viruses take place in specific cytoplasmic inclusions called inclusion bodies (IBs). These activities depend on viral polymerase L, associated with its cofactor phosphoprotein P, for the recognition of the viral RNA genome encapsidated by the nucleoprotein N, forming the nucleocapsid (NC). The polymerase activities rely on diverse transient protein-protein interactions orchestrated by P playing the hub role. Among these interactions, P interacts with the NC to recruit L to the genome. The P protein also plays the role of chaperone to maintain the neosynthesized N monomeric and RNA-free (called N0) before specific encapsidation of the viral genome and antigenome. This review aims at giving an overview of recent structural information obtained for hRSV and hMPV P, N, and more specifically for P-NC and N0-P complexes that pave the way for the rational design of new antivirals against those viruses.

Published
2021
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26. Increased levels of GM-CSF and CXCL10 and low CD8+ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people.

Author

Poisson, Johanne, El-Sissy, Carine, Serret-Larmande, Arnaud, Smith, Nikaïa, Lebraud, Morgane, Augy, Jean-Loup, Conti, Catherine, Gonnin, Cécile, Planquette, Benjamin, Arlet, Jean-Benoît, Hermann, Bertrand, Charbit, Bruno, Pastre, Jean, Devaux, Floriane, Ladavière, Cyrielle, Lim, Lydie, Ober, Pauline, Cannovas, Johanna, Biard, Lucie, and Gulczynski, Marie-Christelle

Subjects
OLDER people, IMMUNOLOGIC memory, CHEMOKINES, IMMUNOSENESCENCE, ELDER care
Abstract

Background: Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly. Immune ageing is a heterogeneous process also associated with inflammaging, a low-grade chronic inflammation. Altered cytotoxic T cell responses and cytokine storm have previously been described in severe COVID-19 cases, however the parameters responsible for such immune response failures are not well known. The aim of our study was to characterize CD8+ T cells and cytokines associated with ageing, in a cohort of patients aged over 70 years stratified by COVID-19 severity. Results: One hundred and four patients were included in the study. We found that, in older people, COVID-19 severity was associated with (i) higher level of GM-CSF, CXCL10 (IP-10), VEGF, IL-1β, CCL2 (MCP-1) and the neutrophil to lymphocyte ratio (NLR), (ii) increased terminally differentiated CD8+T cells, and (ii) decreased early precursors CD8+ T stem cell-like memory cells (TSCM) and CD27+CD28+. The cytokines mentioned above were found at higher concentrations in the COVID-19+ older cohort compared to a younger cohort in which they were not associated with disease severity. Conclusions: Our results highlight the particular importance of the myeloid lineage in COVID-19 severity among older people. As GM-CSF and CXCL10 were not associated with COVID-19 severity in younger patients, they may represent disease severity specific markers of ageing and should be considered in older people care. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Preexisting autoantibodies as predictor of immune related adverse events (irAEs) for advanced solid tumors treated with immune checkpoint inhibitors (ICIs)

Author

Daban, A, primary, Gonnin, C, additional, Phan, L, additional, Saldmann, A, additional, Granier, C, additional, Lillo-Lelouet, A, additional, Le Beller, C, additional, Pouchot, J, additional, Weiss, l, additional, Tartour, E, additional, Fabre, E, additional, Medioni, J, additional, Oudard, S, additional, Vano, YA, additional, Dragon-Durey, MA, additional, and Simonaggio, A., additional

Published
2023
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28. Beam test performance of the SKIROC2 ASIC

Author

Amjad, M.S., Anduze, M., Augustin, J.-E., Bonis, J., Boudry, V., Bourgeois, C., Brient, J.-C., Callier, S., Cerutti, M., Chen, S., Cornat, R., Cornebise, P., Cuisy, D., David, J., de la Taille, C., Dulucq, F., Frisson, T., Frotin, M., Gastaldi, F., Ghislain, P., Giraud, J., Gonnin, A., Grondin, D., Guliyev, E., Hostachy, J.-Y., Jeans, D., Kamiya, Y., Kawagoe, K., Kozakai, C., Lacour, D., Lavergne, L., Lee, S.H., Magniette, F., Ono, H., Poeschl, R., Rouëné, J., Seguin-Moreau, N., Song, H.S., Sudo, Y., Thiebault, A., Tran, H., Ueno, H., van der Kolk, N., and Yoshioka, T.

Published
2015
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30. Preexisting autoantibodies as predictor of immune-related adverse events for advanced solid tumors treated with immune checkpoint inhibitors.

Author

Daban, Arthur, primary, Gonnin, Cecile, additional, Vano, Yann-Alexandre, additional, Phan, Letuan, additional, lillo-Lelouet, Agnes, additional, le Beller, Christine, additional, Pouchot, Jacques, additional, Fabre, Elizabeth, additional, Weiss, Laurence, additional, Tartour, Eric, additional, Oudard, Stephane, additional, Dragon Durey, Marie-Agnès, additional, and Simonaggio, Audrey, additional

Published
2022
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34. First Electron Beam of the ThomX Project

Author

Bruni, Christelle, Alkadi, Muath, Cayla, Jean-Noël, Chaikovska, Iryna, Chancé, Sophie, Chaumat, Vincent, Dalifard, Olivier, Delerue, Nicolas, Dupraz, Kevin, El Khaldi, Mohamed, ElKamchi, Noureddine, Ergenlik, Ezgi, Gauron, Philippe, Gonnin, Alexandre, Goutierre, Emmanuel, Guler, Hayg, Jacquet, Marie, Kubytskyi, Viacheslav, Lepercq, Pierre, Letellier-Cohen, Frederic, Marrucho, Jean Claude, Mercier, Bruno, Mistretta, Eric, Monard, Hugues, Moutardier, Alexandre, Omeich, Maher, Soskov, V., and Wicek, Francois

Subjects
Physics::Accelerator Physics, MC2: Photon Sources and Electron Accelerators, Accelerator Physics
Abstract

The ThomX accelerator beam commissioning phase is now ongoing. The 50 MeV electron accelerator complex consists of a 50 MeV linear accelerator and a pulsed mode ring. It is dedicated to the production of X-rays by Compton backscattering. The performance of the beam at the interaction point is demanding in terms of emittance, charge, energy spread and transverse size. The choice of an undamped ring in pulsed mode also stresses the performance of the beam from the linear accelerator. Thus, commissioning includes a beam based alignment and a simulation/experimental matching procedure to reach the X-ray beam requirements. We will present the first 50 MeV electron beam obtained with ThomX and its characteristics., Proceedings of the 13th International Particle Accelerator Conference, IPAC2022, Bangkok, Thailand

Published
2022
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35. The ThomX ICS source

Author

Dupraz, K, Alkadi, M, Alves, M, Amoudry, L, Auguste, D, Babigeon, J, Baltazar, M, Benoit, A, Bonis, J, Bonenfant, J, Bruni, C, Cassou, K, Cayla, J, Chabaud, T, Chaikovska, I, Chance, S, Chaumat, V, Chiche, R, Cobessi, A, Cornebise, P, Dalifard, O, Delerue, N, Dorkel, R, Douillet, D, Dugal, J, El Kamchi, N, El Khaldi, M, Ergenlik, E, Favier, P, Fernandez, M, Gamelin, A, Garaut, J, Garolfi, L, Gauron, P, Gauthier, F, Gonnin, A, Grasset, D, Guerard, E, Guler, H, Haissinski, J, Herry, E, Iaquaniello, G, Jacquet, M, Jules, E, Kubytskyi, V, Langlet, M, Le Barillec, T, Ledu, J, Leguidec, D, Leluan, B, Lepercq, P, Letellier-Cohen, F, Marie, R, Marrucho, J, Martens, A, Mageur, C, Mercadier, G, Mercier, B, Mistretta, E, Monard, H, Moutardier, A, Neveu, O, Nutarelli, D, Omeich, M, Peinaud, Y, Petrilli, Y, Pichet, M, Plaige, E, Prevost, C, Rudnicky, P, Soskov, V, Taurigna-Quere, M, Trochet, S, Vallerand, C, Vitez, O, Wicek, F, Wurth, S, Zomer, F, Alexandre, P, Ben El Fekih, R, Berteaud, P, Bouvet, F, Cuoq, R, Diaz, A, Dietrich, Y, Diop, M, Pedeau, D, Dupuy, E, Marteau, F, Helder, D, Hubert, N, Veteran, J, Labat, M, Lestrade, A, Letresor, A, Lopes, R, Loulergue, A, Louvet, M, Marchand, P, El Ajjouri, M, Muller, D, Nadji, A, Nadolski, L, Nagaoka, R, Petit, S, Pollina, J, Ribeiro, F, Ros, M, Salvia, J, Bobault, S, Sebdaoui, M, Sreedharan, R, Bouanai, Y, Hazemann, J, Hodeau, J, Roy, E, Jeantet, P, Lacipiere, J, Robert, P, Horodynski, J, Bzyl, H, Chapelle, C, Biagini, M, Walter, P, Bravin, A, Del Net, W, Lahera, E, Proux, O, Elleaume, H, Cormier, E, Dupraz K., Alkadi M., Alves M., Amoudry L., Auguste D., Babigeon J. -L., Baltazar M., Benoit A., Bonis J., Bonenfant J., Bruni C., Cassou K., Cayla J. -N., Chabaud T., Chaikovska I., Chance S., Chaumat V., Chiche R., Cobessi A., Cornebise P., Dalifard O., Delerue N., Dorkel R., Douillet D., Dugal J. -P., El Kamchi N., El Khaldi M., Ergenlik E., Favier P., Fernandez M., Gamelin A., Garaut J. -F., Garolfi L., Gauron P., Gauthier F., Gonnin A., Grasset D., Guerard E., Guler H., Haissinski J., Herry E., Iaquaniello G., Jacquet M., Jules E., Kubytskyi V., Langlet M., Le Barillec T., Ledu J. -F., Leguidec D., Leluan B., Lepercq P., Letellier-Cohen F., Marie R., Marrucho J. -C., Martens A., Mageur C., Mercadier G., Mercier B., Mistretta E., Monard H., Moutardier A., Neveu O., Nutarelli D., Omeich M., Peinaud Y., Petrilli Y., Pichet M., Plaige E., Prevost C., Rudnicky P., Soskov V., Taurigna-Quere M., Trochet S., Vallerand C., Vitez O., Wicek F., Wurth S., Zomer F., Alexandre P., Ben El Fekih R., Berteaud P., Bouvet F., Cuoq R., Diaz A., Dietrich Y., Diop M., Pedeau D., Dupuy E., Marteau F., Helder D., Hubert N., Veteran J., Labat M., Lestrade A., Letresor A., Lopes R., Loulergue A., Louvet M., Marchand P., El Ajjouri M., Muller D., Nadji A., Nadolski L., Nagaoka R., Petit S., Pollina J. -P., Ribeiro F., Ros M., Salvia J., Bobault S., Sebdaoui M., Sreedharan R., Bouanai Y., Hazemann J. -L., Hodeau J. -L., Roy E., Jeantet P., Lacipiere J., Robert P., Horodynski J. -M., Bzyl H., Chapelle C., Biagini M., Walter P., Bravin A., Del Net W., Lahera E., Proux O., Elleaume H., Cormier E., Dupraz, K, Alkadi, M, Alves, M, Amoudry, L, Auguste, D, Babigeon, J, Baltazar, M, Benoit, A, Bonis, J, Bonenfant, J, Bruni, C, Cassou, K, Cayla, J, Chabaud, T, Chaikovska, I, Chance, S, Chaumat, V, Chiche, R, Cobessi, A, Cornebise, P, Dalifard, O, Delerue, N, Dorkel, R, Douillet, D, Dugal, J, El Kamchi, N, El Khaldi, M, Ergenlik, E, Favier, P, Fernandez, M, Gamelin, A, Garaut, J, Garolfi, L, Gauron, P, Gauthier, F, Gonnin, A, Grasset, D, Guerard, E, Guler, H, Haissinski, J, Herry, E, Iaquaniello, G, Jacquet, M, Jules, E, Kubytskyi, V, Langlet, M, Le Barillec, T, Ledu, J, Leguidec, D, Leluan, B, Lepercq, P, Letellier-Cohen, F, Marie, R, Marrucho, J, Martens, A, Mageur, C, Mercadier, G, Mercier, B, Mistretta, E, Monard, H, Moutardier, A, Neveu, O, Nutarelli, D, Omeich, M, Peinaud, Y, Petrilli, Y, Pichet, M, Plaige, E, Prevost, C, Rudnicky, P, Soskov, V, Taurigna-Quere, M, Trochet, S, Vallerand, C, Vitez, O, Wicek, F, Wurth, S, Zomer, F, Alexandre, P, Ben El Fekih, R, Berteaud, P, Bouvet, F, Cuoq, R, Diaz, A, Dietrich, Y, Diop, M, Pedeau, D, Dupuy, E, Marteau, F, Helder, D, Hubert, N, Veteran, J, Labat, M, Lestrade, A, Letresor, A, Lopes, R, Loulergue, A, Louvet, M, Marchand, P, El Ajjouri, M, Muller, D, Nadji, A, Nadolski, L, Nagaoka, R, Petit, S, Pollina, J, Ribeiro, F, Ros, M, Salvia, J, Bobault, S, Sebdaoui, M, Sreedharan, R, Bouanai, Y, Hazemann, J, Hodeau, J, Roy, E, Jeantet, P, Lacipiere, J, Robert, P, Horodynski, J, Bzyl, H, Chapelle, C, Biagini, M, Walter, P, Bravin, A, Del Net, W, Lahera, E, Proux, O, Elleaume, H, Cormier, E, Dupraz K., Alkadi M., Alves M., Amoudry L., Auguste D., Babigeon J. -L., Baltazar M., Benoit A., Bonis J., Bonenfant J., Bruni C., Cassou K., Cayla J. -N., Chabaud T., Chaikovska I., Chance S., Chaumat V., Chiche R., Cobessi A., Cornebise P., Dalifard O., Delerue N., Dorkel R., Douillet D., Dugal J. -P., El Kamchi N., El Khaldi M., Ergenlik E., Favier P., Fernandez M., Gamelin A., Garaut J. -F., Garolfi L., Gauron P., Gauthier F., Gonnin A., Grasset D., Guerard E., Guler H., Haissinski J., Herry E., Iaquaniello G., Jacquet M., Jules E., Kubytskyi V., Langlet M., Le Barillec T., Ledu J. -F., Leguidec D., Leluan B., Lepercq P., Letellier-Cohen F., Marie R., Marrucho J. -C., Martens A., Mageur C., Mercadier G., Mercier B., Mistretta E., Monard H., Moutardier A., Neveu O., Nutarelli D., Omeich M., Peinaud Y., Petrilli Y., Pichet M., Plaige E., Prevost C., Rudnicky P., Soskov V., Taurigna-Quere M., Trochet S., Vallerand C., Vitez O., Wicek F., Wurth S., Zomer F., Alexandre P., Ben El Fekih R., Berteaud P., Bouvet F., Cuoq R., Diaz A., Dietrich Y., Diop M., Pedeau D., Dupuy E., Marteau F., Helder D., Hubert N., Veteran J., Labat M., Lestrade A., Letresor A., Lopes R., Loulergue A., Louvet M., Marchand P., El Ajjouri M., Muller D., Nadji A., Nadolski L., Nagaoka R., Petit S., Pollina J. -P., Ribeiro F., Ros M., Salvia J., Bobault S., Sebdaoui M., Sreedharan R., Bouanai Y., Hazemann J. -L., Hodeau J. -L., Roy E., Jeantet P., Lacipiere J., Robert P., Horodynski J. -M., Bzyl H., Chapelle C., Biagini M., Walter P., Bravin A., Del Net W., Lahera E., Proux O., Elleaume H., and Cormier E.

Abstract

ThomX is a new generation Compact Compton Source. It is currently commissioned by and at the IJCLab (Laboratoire de physique des 2 infinis - Irène Joliot-Curie (UMR9012)) at Orsay. The first beam is expected at the begining of 2021. The aim of ThomX is to demonstrate the characteristics of an intense and Compact (lab-size) X-ray source based on Compton Scattering. The performances are mostly driven by the laser optical system which is above the state of the art of stored laser power. Proof of principle of various X-ray techniques will be performed thanks to the versatile ThomX beamline. Firstly, this article presents the machine description. Secondly, the issues and limits of the laser system are discussed. Then, the ThomX beamline is described and the machine status conclude the ThomX presentation. Finally, the expected performances for the next years and the possible experiments that can be made with this new machine are detailed.

Published
2020

36. The ThomX ICS source

Author

Kevin Dupraz, Muath Alkadi, Manuel Alves, Loic Amoudry, Didier Auguste, Jean-Luc Babigeon, Michel Baltazar, Alain Benoit, Julien Bonis, Jean Bonenfant, Christelle Bruni, Kevin Cassou, Jean-Noël Cayla, Thomas Chabaud, Iryna Chaikovska, Sophie Chance, Vincent Chaumat, Ronic Chiche, Alain Cobessi, Patrick Cornebise, Olivier Dalifard, Nicolas Delerue, Remy Dorkel, Denis Douillet, Jean-Phillipe Dugal, Noureddine El Kamchi, Mohamed El Khaldi, Ezgi Ergenlik, Pierre Favier, Marco Fernandez, Alexis Gamelin, Jean-Francois Garaut, Luca Garolfi, Philippe Gauron, Frédéric Gauthier, Alexandre Gonnin, Denis Grasset, Eric Guerard, Hayg Guler, Jacques Haissinski, Emmanuel Herry, Gregory Iaquaniello, Marie Jacquet, Eric Jules, Vlacheslav Kubytskyi, Marc Langlet, Titouan Le Barillec, Jean-François Ledu, Damien Leguidec, Bruno Leluan, Pierre Lepercq, Frédéric Letellier-Cohen, Rodolphe Marie, Jean-Claude Marrucho, Aurélien Martens, Christophe Mageur, Gabriel Mercadier, Bruno Mercier, Eric Mistretta, Hugues Monard, Alexandre Moutardier, Olivier Neveu, Daniele Nutarelli, Maher Omeich, Yann Peinaud, Yann Petrilli, Marc Pichet, Eric Plaige, Christophe Prévost, Philippe Rudnicky, Viktor Soskov, Monique Taurigna-Quéré, Stéphane Trochet, Cynthia Vallerand, Olivier Vitez, François Wicek, Sébastien Wurth, Fabian Zomer, Patrick Alexandre, Rachid Ben El Fekih, Philippe Berteaud, François Bouvet, Renaud Cuoq, Antonio Diaz, Yannick Dietrich, Massamba Diop, Dominique Pedeau, Eric Dupuy, Fabrice Marteau, Dias Helder, Nicolas Hubert, José Veteran, Marie Labat, Alain Lestrade, Antoine Letrésor, Robert Lopes, Alexandre Loulergue, Marc Louvet, Patrick Marchand, Moussa El Ajjouri, Didier Muller, Amor Nadji, Laurent Nadolski, Ryutaro Nagaoka, Sylvain Petit, Jean-Pierre Pollina, Fernand Ribeiro, Manuel Ros, Julien Salvia, Sébastien Bobault, Mourad Sebdaoui, Rajesh Sreedharan, Yazid Bouanai, Jean-Louis Hazemann, Jean-Louis Hodeau, Emmanuel Roy, Philippe Jeantet, Jérôme Lacipière, Pierre Robert, Jean-Michel Horodynski, Harold Bzyl, Christophe Chapelle, Marica Biagini, Philippe Walter, Alberto Bravin, William Del Net, Eric Lahéra, Olivier Proux, Hélène Elleaume, Eric Cormier, Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Matériaux, Rayonnements, Structure (MRS), Institut Néel (NEEL), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), SERAS (SERAS), Ingénierie Radioprotection Sûreté Démantèlement (IRSD), Laboratori Nazionali di Frascati (LNF), Istituto Nazionale di Fisica Nucleare (INFN), Laboratoire d'Archéologie Moléculaire et Structurale (LAMS), Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), European Synchrotron Radiation Facility (ESRF), Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Rayonnement Synchrotron et Recherche Medicale (RSRM), European Synchrotron Radiation Facility (ESRF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), LETELLIER, Frédéric, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Matériaux, Rayonnements, Structure (NEEL - MRS), Service Etudes et Réalisation d'Appareillages Scientifiques (NEEL - SERAS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, Dupraz, K, Alkadi, M, Alves, M, Amoudry, L, Auguste, D, Babigeon, J, Baltazar, M, Benoit, A, Bonis, J, Bonenfant, J, Bruni, C, Cassou, K, Cayla, J, Chabaud, T, Chaikovska, I, Chance, S, Chaumat, V, Chiche, R, Cobessi, A, Cornebise, P, Dalifard, O, Delerue, N, Dorkel, R, Douillet, D, Dugal, J, El Kamchi, N, El Khaldi, M, Ergenlik, E, Favier, P, Fernandez, M, Gamelin, A, Garaut, J, Garolfi, L, Gauron, P, Gauthier, F, Gonnin, A, Grasset, D, Guerard, E, Guler, H, Haissinski, J, Herry, E, Iaquaniello, G, Jacquet, M, Jules, E, Kubytskyi, V, Langlet, M, Le Barillec, T, Ledu, J, Leguidec, D, Leluan, B, Lepercq, P, Letellier-Cohen, F, Marie, R, Marrucho, J, Martens, A, Mageur, C, Mercadier, G, Mercier, B, Mistretta, E, Monard, H, Moutardier, A, Neveu, O, Nutarelli, D, Omeich, M, Peinaud, Y, Petrilli, Y, Pichet, M, Plaige, E, Prevost, C, Rudnicky, P, Soskov, V, Taurigna-Quere, M, Trochet, S, Vallerand, C, Vitez, O, Wicek, F, Wurth, S, Zomer, F, Alexandre, P, Ben El Fekih, R, Berteaud, P, Bouvet, F, Cuoq, R, Diaz, A, Dietrich, Y, Diop, M, Pedeau, D, Dupuy, E, Marteau, F, Helder, D, Hubert, N, Veteran, J, Labat, M, Lestrade, A, Letresor, A, Lopes, R, Loulergue, A, Louvet, M, Marchand, P, El Ajjouri, M, Muller, D, Nadji, A, Nadolski, L, Nagaoka, R, Petit, S, Pollina, J, Ribeiro, F, Ros, M, Salvia, J, Bobault, S, Sebdaoui, M, Sreedharan, R, Bouanai, Y, Hazemann, J, Hodeau, J, Roy, E, Jeantet, P, Lacipiere, J, Robert, P, Horodynski, J, Bzyl, H, Chapelle, C, Biagini, M, Walter, P, Bravin, A, Del Net, W, Lahera, E, Proux, O, Elleaume, H, and Cormier, E

Subjects
Beamline, ThomX, [PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], General Physics and Astronomy, 01 natural sciences, law.invention, 010309 optics, X-ray, Optics, law, 0103 physical sciences, Laser power scaling, Physics, Machine description, 010308 nuclear & particles physics, business.industry, Compton scattering, [PHYS.PHYS.PHYS-ACC-PH] Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], Laser, High power Fabry-Perot cavity, lcsh:QC1-999, Proof of concept, Compact compton source, business, Beam (structure), lcsh:Physics
Abstract

International audience; ThomX is a new generation Compact Compton Source. It is currently commissioned by and at the IJCLab (Laboratoire de physique des 2 infinis - Irène Joliot-Curie (UMR9012)) at Orsay. The first beam is expected at the begining of 2021. The aim of ThomX is to demonstrate the characteristics of an intense and Compact (lab-size) X-ray source based on Compton Scattering. The performances are mostly driven by the laser optical system which is above the state of the art of stored laser power. Proof of principle of various X-ray techniques will be performed thanks to the versatile ThomX beamline. Firstly, this article presents the machine description. Secondly, the issues and limits of the laser system are discussed. Then, the ThomX beamline is described and the machine status conclude the ThomX presentation. Finally, the expected performances for the next years and the possible experiments that can be made with this new machine are detailed.

Published
2020
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40. Protocol for Readability

Author

Bartosz Urbaniak, Michael Ritter, Fernandito Arroyo, Steen Howaldt Christiansen, Ivor Kesic, Brendan Gaffney, BioPhorum, Ludovic Benoit-Gonnin, Robert B Stapleton, and Jannika Kremer

Subjects
Protocol (science), Computer science, business.industry, Artificial intelligence, computer.software_genre, business, computer, Natural language processing, Readability
Published
2021
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43. Curved OLED microdisplays

Author

Cyrille Rossat, Jerome Dechamp, Bertrand Chambion, Marion Provost, Patrick Peray, Marc Zussy, Tony Maindron, Aurelie Vandeneynde, and Stéphanie Gonnin

Subjects
Materials science, business.industry, OLED, Optoelectronics, Electrical and Electronic Engineering, Image sensor, business, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, Grinding, Encapsulation (networking)
Published
2019
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44. A New Discrete-Event Simulation Based Approach for Validating Actuation Conflict Management in IoT Systems

Author

Thibault Gonnin, Jean-François Santucci, Stéphane Lavirotte, Gérald Rocher, Jean-Yves Tigli, and Laurent Capocchi

Subjects
DEVS, Computer science, Formalism (philosophy), Distributed computing, Cognitive neuroscience of visual object recognition, Conflict management, Resolution (logic), Discrete event simulation, Formal verification, Field (computer science)
Abstract

In the field of conflict management of IoT systems, formal verification of the actuation conflict Management (ACM) has an important place to verify the ACM logical properties by considering the events and possible actions on the actuators. In this paper a new discrete event simulation of Internet of Things systems approach is introduced during the Design Phase to: (i) generate test patterns that highlights potential conflicts and (ii) validate the ACM specifications designed to solve the conflicts embedded in the physical environment using the previous test patterns. The DEVS (Discrete EVent system Specification) formalism is used to formally propose a modeling of the IoT system and its physical environment, the definition of an ACM DEVS simulation model allowing conflicts detection and resolution. A use-case example is proposed to illustrate this new approach.

Published
2021
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45. Depletion of TAX1BP1 Amplifies Innate Immune Responses during Respiratory Syncytial Virus Infection

Author

Descamps, Delphyne, primary, Peres de Oliveira, Andressa, additional, Gonnin, Lorène, additional, Madrières, Sarah, additional, Fix, Jenna, additional, Drajac, Carole, additional, Marquant, Quentin, additional, Bouguyon, Edwige, additional, Pietralunga, Vincent, additional, Iha, Hidekatsu, additional, Morais Ventura, Armando, additional, Tangy, Frédéric, additional, Vidalain, Pierre-Olivier, additional, Eléouët, Jean-François, additional, and Galloux, Marie, additional

Published
2021
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46. Preexisting autoantibodies as predictor of immune-related adverse events for advanced solid tumors treated with immune checkpoint inhibitors

Author

Arthur Daban, Cecile Gonnin, Yann-Alexandre Vano, Letuan Phan, Agnes lillo-Lelouet, Christine le Beller, Jacques Pouchot, Elizabeth Fabre, Laurence Weiss, Eric Tartour, Stephane Oudard, Marie-Agnès Dragon Durey, and Audrey Simonaggio

Subjects
Cancer Research, Oncology
Abstract

2523 Background: Immune checkpoint inhibitors (ICIs), used alone or as a combination are standard of care in many cancers. Generally well tolerated, they can generate immune-related adverse events (irAEs). No biomarkers are available to identify patients who are more likely to develop irAEs. The aim of this study was to assess the association between preexisting autoantibodies, occurrence of irAEs and survival outcomes. Methods: We performed a prospective study including 221 patients receiving ICIs for advanced solid tumors between May 2015 and July 2021. Autoantibodies testing (anti-neutrophil cytoplasmic, anti-nuclear, thyroid peroxidase and thyroglobulin) was performed before ICIs initiation. The associations among preexisting autoantibodies, the occurrence, the severity, the delay of irAEs and the survival outcomes, including progression-free survival (PFS) and overall survival (OS) were analyzed. Statistical analyses were performed with T-test, Cox regression models, univariate and multivariate analyses and Kaplan-Meier’s method. Results: Of the 221 patients, 151 (68%) were men, the median age was 66,5 (range 21-90) years and 103 (81%) had an ECOG-PS of 0 or 1. Seventy-three percent (n=162) received an anti-PD-(L)1 in monotherapy, 27% (n=59) an anti-PD-(L)1 in combination, for a renal cell carcinoma in 45% (n=99) and a lung carcinoma in 41% (n=90). In total, 129 (58%) patients had preexisting antibodies. IrAEs were significantly more frequent in patients with preexisting autoantibodies: 64 patients (50%) in the positive group vs. 20 patients (22%) in the negative group, OR = 3.5 (95%CI=1.8 - 6.8), p=0.00002. Median time interval between ICI initiation and irAE was shorter in the positive group vs. the negative group, 13 weeks (IQR=43weeks) vs. 28.5 weeks (IQR=12weeks) respectively (p=0.01). Twelve patients (9.4%) experienced multi toxicities in the positive group vs. two (2%) in the negative group, OR=4.5 (95%CI0.98-36), p=0.04. ICIs exposure was identical in preexisting and non-preexisting autoantibodies groups. After a median follow-up of 25 months (95%CI=19-31), median PFS and OS were significantly longer among patients experiencing irAE: 12.6 months (95%CI=11-22.7) vs 5 months (95%CI=4.2-7.0), p= 0.0003 and 30 months (95%CI= 22.7-NR) vs 21 months (95%CI=15-34.6), p= 0.016. In multivariate analyses irAEs remain statistically associated with survival outcomes. Preexisting autoantibodies were not associated with survival outcomes. Conclusions: The presence of preexisting autoantibodies is significantly associated with the occurrence of irAE in patients treated with ICIs. Earlier and multiple irAEs were observed in the presence of preexisting autoantibodies. Thus, these biomarkers could help to identify patients at risk of irAEs and would prompt us to closely monitor them.

Published
2022
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48. Depletion of TAX1BP1 amplifies innate immune responses during respiratory syncytial virus infection

Author

Marie Galloux, Lorène Gonnin, Delphyne Descamps, Jean-François Eléouët, Carole Drajac, Quentin Marquant, Vincent Pietralunga, Armando Morais Ventura, Frédéric Tangy, Andressa Peres de Oliveira, Pierre-Olivier Vidalain, Sarah Madrières, Hidekatsu Iha, Edwige Bouguyon, Jenna Fix, Virologie et Immunologie Moléculaires (VIM (UR 0892)), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Universidade de São Paulo (USP), Oita University Faculty of Medicine [Oita, Japon], Génomique virale et vaccination, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Centre International de Recherche en Infectiologie - UMR (CIRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), ANR-13-ISV3-0007,RESPISYNCYCELL,Partenaires cellulaires du virus respiratoire syncytial(2013), Universidade de São Paulo = University of São Paulo (USP), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
TAX1BP1, Viral protein, viruses, [SDV]Life Sciences [q-bio], Immunology, ANTIVIRAIS, Context (language use), Respiratory Syncytial Virus Infections, Biology, Virus Replication, medicine.disease_cause, Microbiology, Virus, Cell Line, Mice, 03 medical and health sciences, Immune system, Cricetinae, Virology, medicine, Animals, Humans, Pathogen, Lung, 030304 developmental biology, Nucleoprotein, Mice, Knockout, Innate immunity, 0303 health sciences, Innate immune system, 030306 microbiology, Intracellular Signaling Peptides and Proteins, RSV, Nucleocapsid Proteins, Immunity, Innate, Yeast two-hybrid screening, Virus-Cell Interactions, Neoplasm Proteins, 3. Good health, medicine.anatomical_structure, Viral replication, Respiratory Syncytial Virus, Human, Insect Science, Interferons, Respiratory tract
Abstract

Respiratory syncytial virus (RSV) is the main cause of acute respiratory infections in young children, and also has a major impact in the elderly and immunocompromised people. In the absence of vaccine or efficient treatment, a better understanding of RSV interactions with the host antiviral response during infection is needed. Previous studies revealed that cytoplasmic inclusion bodies (IBs) where viral replication and transcription occur could play a major role in the control of innate immunity during infection by recruiting cellular proteins involved in the host antiviral response. We recently showed that the morphogenesis of IBs relies on a liquid-liquid phase separation mechanism depending on the interaction between viral nucleoprotein (N) and phosphoprotein (P). These scaffold proteins are expected to play a central role in the recruitment of cellular proteins to IBs. Here, we performed a yeast two-hybrid screen using RSV N protein as a bait, and identified the cellular protein TAX1BP1 as a potential partner of N. This interaction was validated by pulldown and immunoprecipitation assays. We showed that TAX1BP1 suppression has only a limited impact on RSV infection in cell cultures. On the contrary, in vivo experiments showed that RSV replication is decreased in TAX1BP1KO mice, whereas the production of inflammatory and antiviral cytokines is enhanced. In vitro infection of either wild-type or TAX1BP1KO alveolar macrophages confirmed that the innate immune response to RSV infection is enhanced in the absence of TAX1BP1. Altogether, our results suggest that RSV could hijack TAX1BP1 to restrain the host immune response during infection.ImportanceRespiratory syncytial virus (RSV), which is the leading cause of lower respiratory tract illness in infants, still remains a medical problem in the absence of vaccine or efficient treatment. This virus is also recognized as a main pathogen in the elderly and immunocompromised people, and the occurrence of co-infections (with other respiratory viruses and bacteria) amplifies the risks of developing respiratory distress. In this context, a better understanding of the pathogenesis associated to viral respiratory infections, which depends on both viral replication and the host immune response, is needed. The present study reveals that the cellular protein TAX1BP1, which interacts with the RSV nucleoprotein N, participates in the control of the innate immune response during RSV infection, suggesting that N-TAX1BP1 interaction represents a new target for the development of antivirals.

Published
2021
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