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11. Supplementary Text from Reduced NF1 Expression Confers Resistance to EGFR Inhibition in Lung Cancer

Author

de Bruin, Elza C., primary, Cowell, Catherine, primary, Warne, Patricia H., primary, Jiang, Ming, primary, Saunders, Rebecca E., primary, Melnick, Mary Ann, primary, Gettinger, Scott, primary, Walther, Zenta, primary, Wurtz, Anna, primary, Heynen, Guus J., primary, Heideman, Daniëlle A.M., primary, Gómez-Román, Javier, primary, García-Castaño, Almudena, primary, Gong, Yixuan, primary, Ladanyi, Marc, primary, Varmus, Harold, primary, Bernards, René, primary, Smit, Egbert F., primary, Politi, Katerina, primary, and Downward, Julian, primary

Published
2023
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12. Supplementary Data 2 from Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade

Author

Gong, Yixuan, primary, Wang, Li, primary, Yu, Haocheng, primary, Alpert, Naomi, primary, Cohen, Mitchell D., primary, Prophete, Colette, primary, Horton, Lori, primary, Sisco, Maureen, primary, Park, Sung-Hyun, primary, Lee, Hyun-Wook, primary, Zelikoff, Judith, primary, Chen, Lung-Chi, primary, Hashim, Dana, primary, Suarez-Farinas, Mayte, primary, Donovan, Michael J., primary, Aaronson, Stuart A., primary, Galsky, Matthew, primary, Zhu, Jun, primary, Taioli, Emanuela, primary, and Oh, William K., primary

Published
2023
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13. Supplementary Table S3 from Reduced NF1 Expression Confers Resistance to EGFR Inhibition in Lung Cancer

Author

de Bruin, Elza C., primary, Cowell, Catherine, primary, Warne, Patricia H., primary, Jiang, Ming, primary, Saunders, Rebecca E., primary, Melnick, Mary Ann, primary, Gettinger, Scott, primary, Walther, Zenta, primary, Wurtz, Anna, primary, Heynen, Guus J., primary, Heideman, Daniëlle A.M., primary, Gómez-Román, Javier, primary, García-Castaño, Almudena, primary, Gong, Yixuan, primary, Ladanyi, Marc, primary, Varmus, Harold, primary, Bernards, René, primary, Smit, Egbert F., primary, Politi, Katerina, primary, and Downward, Julian, primary

Published
2023
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14. Supplementary Tables S1 and S2 from Reduced NF1 Expression Confers Resistance to EGFR Inhibition in Lung Cancer

Author

de Bruin, Elza C., primary, Cowell, Catherine, primary, Warne, Patricia H., primary, Jiang, Ming, primary, Saunders, Rebecca E., primary, Melnick, Mary Ann, primary, Gettinger, Scott, primary, Walther, Zenta, primary, Wurtz, Anna, primary, Heynen, Guus J., primary, Heideman, Daniëlle A.M., primary, Gómez-Román, Javier, primary, García-Castaño, Almudena, primary, Gong, Yixuan, primary, Ladanyi, Marc, primary, Varmus, Harold, primary, Bernards, René, primary, Smit, Egbert F., primary, Politi, Katerina, primary, and Downward, Julian, primary

Published
2023
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15. Supplementary Figures 1-7 from Reduced NF1 Expression Confers Resistance to EGFR Inhibition in Lung Cancer

Author

de Bruin, Elza C., primary, Cowell, Catherine, primary, Warne, Patricia H., primary, Jiang, Ming, primary, Saunders, Rebecca E., primary, Melnick, Mary Ann, primary, Gettinger, Scott, primary, Walther, Zenta, primary, Wurtz, Anna, primary, Heynen, Guus J., primary, Heideman, Daniëlle A.M., primary, Gómez-Román, Javier, primary, García-Castaño, Almudena, primary, Gong, Yixuan, primary, Ladanyi, Marc, primary, Varmus, Harold, primary, Bernards, René, primary, Smit, Egbert F., primary, Politi, Katerina, primary, and Downward, Julian, primary

Published
2023
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16. Data from Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade

Author

Gong, Yixuan, primary, Wang, Li, primary, Yu, Haocheng, primary, Alpert, Naomi, primary, Cohen, Mitchell D., primary, Prophete, Colette, primary, Horton, Lori, primary, Sisco, Maureen, primary, Park, Sung-Hyun, primary, Lee, Hyun-Wook, primary, Zelikoff, Judith, primary, Chen, Lung-Chi, primary, Hashim, Dana, primary, Suarez-Farinas, Mayte, primary, Donovan, Michael J., primary, Aaronson, Stuart A., primary, Galsky, Matthew, primary, Zhu, Jun, primary, Taioli, Emanuela, primary, and Oh, William K., primary

Published
2023
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17. Data from Reduced NF1 Expression Confers Resistance to EGFR Inhibition in Lung Cancer

Author

de Bruin, Elza C., primary, Cowell, Catherine, primary, Warne, Patricia H., primary, Jiang, Ming, primary, Saunders, Rebecca E., primary, Melnick, Mary Ann, primary, Gettinger, Scott, primary, Walther, Zenta, primary, Wurtz, Anna, primary, Heynen, Guus J., primary, Heideman, Daniëlle A.M., primary, Gómez-Román, Javier, primary, García-Castaño, Almudena, primary, Gong, Yixuan, primary, Ladanyi, Marc, primary, Varmus, Harold, primary, Bernards, René, primary, Smit, Egbert F., primary, Politi, Katerina, primary, and Downward, Julian, primary

Published
2023
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18. Supplementary Data 1 from Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade

Author

Gong, Yixuan, primary, Wang, Li, primary, Yu, Haocheng, primary, Alpert, Naomi, primary, Cohen, Mitchell D., primary, Prophete, Colette, primary, Horton, Lori, primary, Sisco, Maureen, primary, Park, Sung-Hyun, primary, Lee, Hyun-Wook, primary, Zelikoff, Judith, primary, Chen, Lung-Chi, primary, Hashim, Dana, primary, Suarez-Farinas, Mayte, primary, Donovan, Michael J., primary, Aaronson, Stuart A., primary, Galsky, Matthew, primary, Zhu, Jun, primary, Taioli, Emanuela, primary, and Oh, William K., primary

Published
2023
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19. Supplementary Figures from Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade

Author

Gong, Yixuan, primary, Wang, Li, primary, Yu, Haocheng, primary, Alpert, Naomi, primary, Cohen, Mitchell D., primary, Prophete, Colette, primary, Horton, Lori, primary, Sisco, Maureen, primary, Park, Sung-Hyun, primary, Lee, Hyun-Wook, primary, Zelikoff, Judith, primary, Chen, Lung-Chi, primary, Hashim, Dana, primary, Suarez-Farinas, Mayte, primary, Donovan, Michael J., primary, Aaronson, Stuart A., primary, Galsky, Matthew, primary, Zhu, Jun, primary, Taioli, Emanuela, primary, and Oh, William K., primary

Published
2023
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20. Supplementary Data 3 from Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade

Author

Gong, Yixuan, primary, Wang, Li, primary, Yu, Haocheng, primary, Alpert, Naomi, primary, Cohen, Mitchell D., primary, Prophete, Colette, primary, Horton, Lori, primary, Sisco, Maureen, primary, Park, Sung-Hyun, primary, Lee, Hyun-Wook, primary, Zelikoff, Judith, primary, Chen, Lung-Chi, primary, Hashim, Dana, primary, Suarez-Farinas, Mayte, primary, Donovan, Michael J., primary, Aaronson, Stuart A., primary, Galsky, Matthew, primary, Zhu, Jun, primary, Taioli, Emanuela, primary, and Oh, William K., primary

Published
2023
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21. Data from Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer

Author

McClinch, Kimberly, primary, Avelar, Rita A., primary, Callejas, David, primary, Izadmehr, Sudeh, primary, Wiredja, Danica, primary, Perl, Abbey, primary, Sangodkar, Jaya, primary, Kastrinsky, David B., primary, Schlatzer, Daniela, primary, Cooper, Maxwell, primary, Kiselar, Janna, primary, Stachnik, Agnes, primary, Yao, Shen, primary, Hoon, Divya, primary, McQuaid, Daniel, primary, Zaware, Nilesh, primary, Gong, Yixuan, primary, Brautigan, David L., primary, Plymate, Stephen R., primary, Sprenger, Cynthia C.T., primary, Oh, William K., primary, Levine, Alice C., primary, Kirschenbaum, Alexander, primary, Sfakianos, John P., primary, Sears, Rosalie, primary, DiFeo, Analisa, primary, Ioannou, Yiannis, primary, Ohlmeyer, Michael, primary, Narla, Goutham, primary, and Galsky, Matthew D., primary

Published
2023
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22. Supplementary Materials and Methods from Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer

Author

McClinch, Kimberly, primary, Avelar, Rita A., primary, Callejas, David, primary, Izadmehr, Sudeh, primary, Wiredja, Danica, primary, Perl, Abbey, primary, Sangodkar, Jaya, primary, Kastrinsky, David B., primary, Schlatzer, Daniela, primary, Cooper, Maxwell, primary, Kiselar, Janna, primary, Stachnik, Agnes, primary, Yao, Shen, primary, Hoon, Divya, primary, McQuaid, Daniel, primary, Zaware, Nilesh, primary, Gong, Yixuan, primary, Brautigan, David L., primary, Plymate, Stephen R., primary, Sprenger, Cynthia C.T., primary, Oh, William K., primary, Levine, Alice C., primary, Kirschenbaum, Alexander, primary, Sfakianos, John P., primary, Sears, Rosalie, primary, DiFeo, Analisa, primary, Ioannou, Yiannis, primary, Ohlmeyer, Michael, primary, Narla, Goutham, primary, and Galsky, Matthew D., primary

Published
2023
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23. Supplementary Methods and Figure Legends from Novel D761Y and Common Secondary T790M Mutations in Epidermal Growth Factor Receptor–Mutant Lung Adenocarcinomas with Acquired Resistance to Kinase Inhibitors

Author

Balak, Marissa N., primary, Gong, Yixuan, primary, Riely, Gregory J., primary, Somwar, Romel, primary, Li, Allan R., primary, Zakowski, Maureen F., primary, Chiang, Anne, primary, Yang, Guangli, primary, Ouerfelli, Ouathek, primary, Kris, Mark G., primary, Ladanyi, Marc, primary, Miller, Vincent A., primary, and Pao, William, primary

Published
2023
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24. STR DNA Profiling for Cell Line Authentication from Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer

Author

McClinch, Kimberly, primary, Avelar, Rita A., primary, Callejas, David, primary, Izadmehr, Sudeh, primary, Wiredja, Danica, primary, Perl, Abbey, primary, Sangodkar, Jaya, primary, Kastrinsky, David B., primary, Schlatzer, Daniela, primary, Cooper, Maxwell, primary, Kiselar, Janna, primary, Stachnik, Agnes, primary, Yao, Shen, primary, Hoon, Divya, primary, McQuaid, Daniel, primary, Zaware, Nilesh, primary, Gong, Yixuan, primary, Brautigan, David L., primary, Plymate, Stephen R., primary, Sprenger, Cynthia C.T., primary, Oh, William K., primary, Levine, Alice C., primary, Kirschenbaum, Alexander, primary, Sfakianos, John P., primary, Sears, Rosalie, primary, DiFeo, Analisa, primary, Ioannou, Yiannis, primary, Ohlmeyer, Michael, primary, Narla, Goutham, primary, and Galsky, Matthew D., primary

Published
2023
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25. Supplemental Tables S1-S19. from Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer

Author

McClinch, Kimberly, primary, Avelar, Rita A., primary, Callejas, David, primary, Izadmehr, Sudeh, primary, Wiredja, Danica, primary, Perl, Abbey, primary, Sangodkar, Jaya, primary, Kastrinsky, David B., primary, Schlatzer, Daniela, primary, Cooper, Maxwell, primary, Kiselar, Janna, primary, Stachnik, Agnes, primary, Yao, Shen, primary, Hoon, Divya, primary, McQuaid, Daniel, primary, Zaware, Nilesh, primary, Gong, Yixuan, primary, Brautigan, David L., primary, Plymate, Stephen R., primary, Sprenger, Cynthia C.T., primary, Oh, William K., primary, Levine, Alice C., primary, Kirschenbaum, Alexander, primary, Sfakianos, John P., primary, Sears, Rosalie, primary, DiFeo, Analisa, primary, Ioannou, Yiannis, primary, Ohlmeyer, Michael, primary, Narla, Goutham, primary, and Galsky, Matthew D., primary

Published
2023
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26. Figure S1-S5. from Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer

Author

McClinch, Kimberly, primary, Avelar, Rita A., primary, Callejas, David, primary, Izadmehr, Sudeh, primary, Wiredja, Danica, primary, Perl, Abbey, primary, Sangodkar, Jaya, primary, Kastrinsky, David B., primary, Schlatzer, Daniela, primary, Cooper, Maxwell, primary, Kiselar, Janna, primary, Stachnik, Agnes, primary, Yao, Shen, primary, Hoon, Divya, primary, McQuaid, Daniel, primary, Zaware, Nilesh, primary, Gong, Yixuan, primary, Brautigan, David L., primary, Plymate, Stephen R., primary, Sprenger, Cynthia C.T., primary, Oh, William K., primary, Levine, Alice C., primary, Kirschenbaum, Alexander, primary, Sfakianos, John P., primary, Sears, Rosalie, primary, DiFeo, Analisa, primary, Ioannou, Yiannis, primary, Ohlmeyer, Michael, primary, Narla, Goutham, primary, and Galsky, Matthew D., primary

Published
2023
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27. Supplementary Figures 1-3 from Novel D761Y and Common Secondary T790M Mutations in Epidermal Growth Factor Receptor–Mutant Lung Adenocarcinomas with Acquired Resistance to Kinase Inhibitors

Author

Balak, Marissa N., primary, Gong, Yixuan, primary, Riely, Gregory J., primary, Somwar, Romel, primary, Li, Allan R., primary, Zakowski, Maureen F., primary, Chiang, Anne, primary, Yang, Guangli, primary, Ouerfelli, Ouathek, primary, Kris, Mark G., primary, Ladanyi, Marc, primary, Miller, Vincent A., primary, and Pao, William, primary

Published
2023
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28. Inhibition of pathologic immunoglobulin E in food allergy by EBF-2 and active compound berberine associated with immunometabolism regulation

Author

Yang, Nan, primary, Maskey, Anish R., additional, Srivastava, Kamal, additional, Kim, Monica, additional, Wang, Zixi, additional, Musa, Ibrahim, additional, Shi, Yanmei, additional, Gong, Yixuan, additional, Fidan, Ozkan, additional, Wang, Julie, additional, Dunkin, David, additional, Chung, Danna, additional, Zhan, Jixun, additional, Miao, Mingsan, additional, Sampson, Hugh A., additional, and Li, Xiu-Min, additional

Published
2023
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29. Inhibition of Pathologic Immunoglobulin E In Food Allergy by EBF2 and Active Compound Berberine Associated with Immunometabolism Regulation

Author

Maskey, Anish, primary, Yang, Nan, additional, Kim, Monica, additional, Srivastava, Kamal, additional, Wang, Zixi, additional, Shi, Yanmei, additional, Gong, Yixuan, additional, Wang, Julie, additional, Dunkin, David, additional, Chung, Danna, additional, Zhan, Jixun, additional, Miao, Mingsan, additional, Sampson, Hugh, additional, and Li, Xiu-Min, additional

Published
2023
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33. In situ crystal engineering on 3D-printed woodpile scaffolds: a monolith catalyst with highly accessible active sites for enhanced catalytic cracking.

Author

Wang, Ruoyu, Gong, Yixuan, Wang, Peng, He, Wenhui, Song, Ye, Xin, Mudi, Jiang, Qiuqiao, Sha, Yuchen, Cao, Tiantian, Song, Haitao, and Lin, Wei

Abstract

Catalytic cracking of low-value oil fractions over ZSM-5 zeolites is a vital processing method for the manufacture of light olefins as critical building blocks in the petrochemical industry. Exploring novel zeolite engineering technologies that allow for better access to active sites and an optimized flow regime has long been one of the most important issues among scientific topics as well as in industrial practices. Herein, a monolith zeolitic catalyst with highly accessible active sites for enhanced catalytic cracking was fabricated by in situ crystal engineering on a digital light processing (DLP) 3D-printed woodpile scaffold. By anchoring crystal seeds onto the scaffold, a thick layer of ZSM-5 nanocrystals (ca. 60 μm) was in situ created on the monolith surface with the assistance of hydrothermal treatment, forming monolith zeolitic catalysts (MC-Z) with a high crystallinity of 41.2%. Such a high ZSM-5 loading on the 3D-printed scaffold surface enabled more acid sites to be accessible in catalytic reactions. In addition, a remarkable mass transfer advantage was revealed in the fabricated monolith zeolitic catalysts owing to their radial interconnected channels. The monolith zeolitic catalyst demonstrated superior activity in 1,3,5-triisopropylbenzene (TIPB) and n-octane cracking reactions. This strategy can be extended to other catalytic systems requiring highly accessible active sites to achieve further catalytic efficiency improvement as well as process intensification. [ABSTRACT FROM AUTHOR]

Published
2023
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34. EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer

Author

Wang, Li, Saci, Abdel, Szabo, Peter M., Chasalow, Scott D., Castillo-Martin, Mireia, Domingo-Domenech, Josep, Siefker-Radtke, Arlene, Sharma, Padmanee, Sfakianos, John P., Gong, Yixuan, Dominguez-Andres, Ana, Oh, William K., Mulholland, David, Azrilevich, Alex, Hu, Liangyuan, Cordon-Cardo, Carlos, Salmon, Hélène, Bhardwaj, Nina, Zhu, Jun, and Galsky, Matthew D.

Published
2018
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39. Global DNA methylation of WTC prostate cancer tissues show signature differences compared to non-exposed cases

Author

Yu, Haocheng, primary, Tuminello, Stephanie, additional, Alpert, Naomi, additional, van Gerwen, Maaike, additional, Yoo, Seungyeul, additional, Mulholland, David J, additional, Aaronson, Stuart A, additional, Donovan, Michael, additional, Oh, William K, additional, Gong, Yixuan, additional, Wang, Li, additional, Zhu, Jun, additional, and Taioli, Emanuela, additional

Published
2022
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40. Ultra-thin Two-Dimensional Trimetallic Metal–Organic Framework for Photocatalytic Reduction of CO2

Author

Hu, Mingliang, primary, Liu, Jiahao, additional, Song, Shaojia, additional, Wang, Weiwei, additional, Yao, Jiasai, additional, Gong, Yixuan, additional, Li, Chenyu, additional, Li, Huan, additional, Li, Yanjie, additional, Yuan, Xilin, additional, Fang, Zhao, additional, Xu, Hao, additional, Song, Weiyu, additional, and Li, Zhenxing, additional

Published
2022
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44. Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer

Author

Regales, Lucia, Gong, Yixuan, Shen, Ronglai, Stanchina, Elisa de, Vivanco, Igor, Goel, Aviva, Koutcher, Jason A., Spassova, Maria, Ouerfelli, Ouathek, Mellinghoff, Ingo K., Zakowski, Maureen F., Politi, Katerina A., and Pao, William

Subjects
Gene mutations -- Identification and classification -- Genetic aspects, Drug resistance -- Drug therapy -- Genetic aspects, Lung cancer -- Drug therapy -- Genetic aspects, Health care industry
Abstract

EGFR is a major anticancer drug target in human epithelial tumors. One effective class of agents is the tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib. These drugs induce dramatic responses in individuals with lung adenocarcinomas characterized by mutations in exons encoding the EGFR tyrosine kinase domain, but disease progression invariably occurs. A major reason for such acquired resistance is the outgrowth of tumor cells with additional TKI-resistant EGFR mutations. Here we used relevant transgenic mouse lung tumor models to evaluate strategies to overcome the most common EGFR TKI resistance mutation, T790M. We treated mice bearing tumors harboring EGFR mutations with a variety of anticancer agents, including a new irreversible EGFR TKI that is under development (BIBW-2992) and the EGFR-specific antibody cetuximab. Surprisingly, we found that only the combination of both agents together induced dramatic shrinkage of erlotinib-resistant tumors harboring the T790M mutation, because together they efficiently depleted both phosphorylated and total EGFR. We suggest that these studies have immediate therapeutic implications for lung cancer patients, as dual targeting with cetuximab and a second-generation EGFR TKI maybe an effective strategy to overcome T790M-mediated drug resistance. Moreover, this approach could serve as an important model for targeting other receptor tyrosine kinases activated in human cancers., Introduction The EGFR is a membrane-bound receptor tyrosine kinase that belongs to a subfamily of 4 closely related receptors: HER1/EGFR/ERBB1, HER2/NEU/ERBB2, HER3/ERBB3, and HER4/ERBB4. Upon binding to extracellular ligands, the [...]

Published
2009
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45. Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas

Author

Gong, Yixuan, Somwar, Romel, Politi, Katerina, Balak, Marissa, Chmielecki, Juliann, Jiang, Xuejun, and Pao, William

Subjects
Mutation (Biology) -- Risk factors -- Research -- Genetic aspects, Lung cancer -- Risk factors -- Genetic aspects -- Research, Biological sciences
Abstract

ABSTRACT Background Mutations in the epidermal growth factor receptor (EGFR) gene are associated with increased sensitivity of lung cancers to kinase inhibitors like erlotinib. Mechanisms of cell death that occur [...]

Published
2007

50. Fibroblast Growth Factor Receptor 3 Alterations and Response to PD-1/PD-L1 Blockade in Patients with Metastatic Urothelial Cancer

Author

Wang, Li, primary, Gong, Yixuan, additional, Saci, Abdel, additional, Szabo, Peter M., additional, Martini, Alberto, additional, Necchi, Andrea, additional, Siefker-Radtke, Arlene, additional, Pal, Sumanta, additional, Plimack, Elizabeth R., additional, Sfakianos, John P., additional, Bhardwaj, Nina, additional, Horowitz, Amir, additional, Farkas, Adam M., additional, Mulholland, David, additional, Fischer, Bruce S., additional, Oh, William K., additional, Sharma, Padmanee, additional, Zhu, Jun, additional, and Galsky, Matthew D., additional

Published
2019
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