Search

Your search keyword '"Gong, Yanping"' showing total 555 results
Start Over Author "Gong, Yanping"
555 results on '"Gong, Yanping"'

8. A multicenter prospective study of comprehensive metagenomic and transcriptomic signatures for predicting outcomes of patients with severe community-acquired pneumonia

Author

Zhao, Jingya, He, Xiangyan, Min, Jiumeng, Yao, Rosary Sin Yu, Chen, Yu, Chen, Zhonglin, Huang, Yi, Zhu, Zhongyi, Gong, Yanping, Xie, Yusang, Li, Yuping, Luo, Weiwei, Shi, Dongwei, Xu, Jinfu, Shen, Ao, Wang, Qiuyue, Sun, Ruixue, He, Bei, Lin, Yang, Shen, Ning, Cao, Bin, Yang, Lingling, She, Danyang, Shi, Yi, Zhou, Jiali, Su, Xin, Zhou, Hua, Ma, Zhenzi, Fan, Hong, Lin, Yongquan, Ye, Feng, Nie, Xifang, Zhang, Qiao, Tian, Xinlun, Lai, Guoxiang, Zhou, Min, Ma, Jinmin, Zhang, Jing, and Qu, Jieming

Published
2023
Full Text
View/download PDF

25. Bone Marrow Disseminated Tumor Cell Detection Is Beneficial for the Early Finding of Bone Metastasis and Prognosis.

Author

Wang, Yulan, Liu, Jun, Gong, Yanping, Hu, Binjie, Xie, Jianzhu, Cheng, Jin, and Huang, Qian

Subjects
BONE marrow cancer, BONE metastasis, CANCER relapse, PROSTATE cancer patients, CANCER prognosis, PROSTATE cancer
Abstract

Background: Disseminated tumor cells (DTCs) are thought to be the initiators of tumor recurrence and metastasis. However, based on the current imaging examination methods, early detection of DTCs is extremely difficult due to their small number and dormant state. Methods: We used the SE-iFISH approach to detect bone marrow DTCs (mDTCs) in patients with breast or prostate cancer, and compared it with various imaging examination methods to explore its role in predicting metastasis and prognosis. Results: Fifteen patients were enrolled in this study. Among them, 11 patients showed imaging-confirmed bone metastases in different sites of the body, of which seven patients had iliac mDTCs and signs of iliac bone metastases on imaging. For the remaining four patients, imaging confirmed that the bone metastatic foci were far from the ilium, but in one patient, mDTCs were detected in the ilium. Interestedly, iliac mDTCs were also detected in two out of four patients who had no sign of bone metastases on imaging. Furthermore, the epithelial marker, CK18, was ubiquitously expressed in mDTCs, but its expression was very low in peripheral circulating tumor cells (pCTCs). The Kaplan–Meier plot suggested that CK18+ mDTCs ≥ 5 was related to poor overall survival (OS) compared with that of CK18+ mDTCs < 5 in breast cancer patients (median OS: 22.1 vs. 46.9 months; log-rank, p = 0.035). Conclusions: SE-iFISH examination for mDTCs is more sensitive than the conventional methods used for detecting bone metastases. mDTC detection facilitated the early finding of tumor cells in the bone marrow and ≥5 CK18+ mDTCs was associated with a poor prognosis in breast cancer patients. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

28. Effect and Interactions of BRAF on Lymph Node Metastasis in Papillary Thyroid Carcinoma With Hashimoto Thyroiditis.

Author

Li, Pengyu, Liu, Yang, Wei, Tao, Wang, Xiaofei, Zhu, Jingqiang, Yang, Rui, Gong, Yanping, and Zhao, Wanjun

Abstract

Context The role of B-Raf proto-oncogene (BRAF) in papillary thyroid carcinoma (PTC) with Hashimoto thyroiditis (HT) is unknown. Objective We aimed to explore risk factors affecting lymph node (LN) metastasis and interaction effect of BRAF in PTC patients with HT. Methods We retrospectively collected the data of 994 PTC patients with HT who underwent surgery at the West China Hospital. We analyzed the correlations between preoperative characteristics and LN metastasis in overall, and different BRAFV600E -mutation patients. Logistic regression was applied to analyze the risk factors for LN metastasis. Finally, we performed an interaction effect analysis to identify the interaction effect of BRAF. Results The overall LN metastasis rate was 52.71% (524/994); the overall BRAF mutation rate was 26.9% (268/994). BRAF mutation rates were significantly different in LN metastasis and nonmetastasis patients (31.7% vs 21.5%; P <.001). In all 994 patients, age, body mass index (BMI), hypertension, tumor maximum diameter, BRAF mutation, tumor location, aspect ratio, calcification, and extrathyroidal invasion were risk factors for LN metastasis (P <.05). In BRAF -mutant patients, smoking, hypertension, maximum diameter, calcification, and multifocality were risk factors for LN metastasis (P <.05). In BRAF wild-type patients, age, BMI, maximum diameter, tumor location, aspect ratio, tumor shape, calcification, and extrathyroidal invasion were risk factors (P <.05). Additionally, we found statistically significant interactions between BRAF and BMI, hypertension, maximum diameter, and calcification (P <.05), suggesting the potential interaction effect of BRAF. Conclusion BRAF is a risk factor for LN metastasis in PTC with HT. Meanwhile, BRAF can interact with age, BMI, hypertension, and calcification, which together influence LN metastasis. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

34. Pseudorabies virus encephalitis in humans: a case series study

Author

Fan, Siyuan, Yuan, Hongxun, Liu, Lei, Li, Hongfang, Wang, Shengnan, Zhao, Weili, Wu, Yihan, Wang, Pei, Hu, Yafang, Han, Jun, Lyu, Yanli, Zhang, Wuchao, Chen, Peng, Wu, Honglong, Gong, Yanping, Ma, Zhenzi, Li, Yongjun, Yu, JiaoJiao, Qiao, Xiaodong, Li, Guoli, Zhao, Yan, Wang, Dexin, Ren, Haitao, Peng, Bin, Cui, Liying, Wang, Jiawei, and Guan, Hongzhi

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results