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For the face inpainting under arbitrary shape occlusion, the existing methods are easy to produce edge blur and distortion of the inpainting results. In this paper, an algorithm for face inpainting combining edge information with gated convolution is proposed. Firstly, the edge image of occluded area is generated by prior face knowledge to constrain the process of face inpainting. Secondly, the gated convolution holds the ability to extract accurate local feature in the absence of some pixels, and a gated convolution-based generative adversarial network (GAN) for image inpainting is designed. The model consists of two parts: edge connection GAN and image inpainting GAN. The edge connection network uses the binary occlusion image, the image to be repaired and its edge image for training, and realizes the automatic completion and connection of the missing edge image. The image inpainting GAN takes the completed edge image as the guidance information, and combines the occlusion image to repair the missing area. The experimental results show that the inpainting effect of this algorithm is better than that of other algorithms, and its evaluation indicators are better than those of the current image inpainting algorithms based on deep learning.

Solid tumors are usually associated with extracellular acidosis due to their increased dependence on glycolysis and poor vascularization. Cancer cells gradually become adapted to acidic microenvironment and even acquire increased aggressiveness. They are resistant to apoptosis but exhibit increased autophagy that is essential for their survival. We here show that NF- κ B, a master regulator of cellular responses to stress, is upregulated in colorectal cancer cells adapted to acidosis (CRC-AA). NF- κ B is more relied upon for survival in CRC-AA than in their parental cells and drives a robust antioxidant response. Supplementation of antioxidant abolishes the increased sensitivity of CRC-AA to NF- κ B inhibition or depletion, suggesting that NF- κ B supports the survival of CRC-AA by maintaining redox homeostasis. Because SQSTM1/p62 is known to mediate the selective autophagy of GATA4 that augments NF- κ B function, we tested whether the enhanced autophagic flux and consequently the reduction of SQSTM1/p62 in CRC-AA cells could activate the GATA4-NF- κ B axis. Indeed, GATA4 is upregulated in CRC-AA cells and augments the NF- κ B activity that underlies the increased expression of cytokines, inhibition of apoptosis, and reduction of reactive oxygen species. Interestingly, secretory factors derived from HCT15-AA cells, the soluble ICAM-1 in particular, also possess antioxidant cytoprotective effect against acidic stress. Together, our results demonstrate a prosurvival role of the p62-restricted GATA4-NF- κ B axis in cancer cells adapted to acidic microenvironment., Competing Interests: The authors declare that they have no conflict of interest., (Copyright © 2021 Xiaojie Liu et al.)