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9 results on '"Gong, Xing-Yu"'

4. N-Directed, Radical Relay Enantioconvergent Sulfinylation of Distal C(sp3)–H Bonds via Cobalt Catalysis

Author

Xu, Ke-Dong, Gong, Xing-Yu, Li, Meng, Yi, Lin, Qin, Hai-Tao, and Liu, Feng

Abstract

Cobalt-catalyzed enantioconvergent cross-coupling of C(sp3)–H bonds with in situ-generated sulfenate anions is achieved to access chiral sulfoxides, which are found in the structures of many biologically active agents. The more challenging aliphatic C–H bonds as well as sterically hindered substrates containing tertiary C–H bonds could also be tolerated well. Mechanistic studies indicate that the transformation could undergo a CoIIS(O)R-mediated single-electron transfer with N-fluorocarboxamides, followed by a 1,5-hydrogen atom transfer and then a pivotal organocobalt(IV)-controlled enantioselective cross-coupling process. This novel asymmetric radical reaction for C–S bond construction could open a new door for the synthesis of sulfur-centered chiral compounds.

Published
2024
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5. Health-related quality of life in Chinese SLE patients: evidence from 1568 SLE patients and 2610 healthy controls

Author

Wang, Yu-Hua, primary, Sun, Hong-Yu, additional, Liu, Yu-Qi, additional, Gong, Xing-Yu, additional, Xu, Ying, additional, Zong, Qi-Qun, additional, Yu, Guang-Hui, additional, Hu, Wan-Qin, additional, Zhai, Chun-Xia, additional, Wang, Lin-Lin, additional, Yan, Zi-Ye, additional, Zhang, Ting-Yu, additional, Cai, Jing, additional, Li, Mu, additional, Chen, Yang-Fan, additional, Wang, Fang, additional, and Zou, Yan-Feng, additional

Published
2023
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9. N-Directed, Radical Relay Enantioconvergent Sulfinylation of Distal C(sp 3 )-H Bonds via Cobalt Catalysis.

Author

Xu KD, Gong XY, Li M, Yi L, Qin HT, and Liu F

Abstract

Cobalt-catalyzed enantioconvergent cross-coupling of C(sp 3 )-H bonds with in situ -generated sulfenate anions is achieved to access chiral sulfoxides, which are found in the structures of many biologically active agents. The more challenging aliphatic C-H bonds as well as sterically hindered substrates containing tertiary C-H bonds could also be tolerated well. Mechanistic studies indicate that the transformation could undergo a Co II S(O)R-mediated single-electron transfer with N -fluorocarboxamides, followed by a 1,5-hydrogen atom transfer and then a pivotal organocobalt(IV)-controlled enantioselective cross-coupling process. This novel asymmetric radical reaction for C-S bond construction could open a new door for the synthesis of sulfur-centered chiral compounds.

Published
2024
Full Text
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