Search

Internet of things makes the real-time data acquirement of lab management system be possible, and data visualization brings new way to management purpose behavior induction. This article analyzes the design and realization of the real-time visualization inducted Intelligent Laboratory Management System (ILMS), analyzes the requirement of information in ILMS by questionnaires and compared the function with the typical visualization systems. This article describes the design of ILMS in DHU, and empirically analyzes the real-time data visualization and the effect induced in DHU, prompts the future research direction. [ABSTRACT FROM AUTHOR]

The density functional B3LYP method with the 6-31++G(d,p) basis set was used to investigate several N-nitroso- N′, N′-dimethylphenylurea biological molecules in MeCN solution. Geometries obtained from DFT calculation were used to perform natural bond orbital (NBO) analysis. The p characters of two nitrogen natural hybrid orbital (NHO), $\sigma_{\mathrm{N}_{3}\mbox{\scriptsize{--}}\mathrm{N}_{2}}$ bond orbitals, increase with increasing σ values of the substituents on the benzene, which results in a lengthening of the N-N bond. The p character of the oxygen NHO $\sigma_{\mathrm{O}_{1}\mbox{\scriptsize{--}}\mathrm{N}_{2}}$ bond orbital decreases with increasing σ values of the substituents on the benzene, which results in a shortening of the N=O bond. It is also noted that decreased occupancy of the localized $\sigma_{\mathrm{N}_{3}\mbox{\scriptsize{--}}\mathrm{N}_{2}}$ orbital occurs in the idealized Lewis structure, or increased occupancy of $\sigma_{\mathrm{N}_{3}\mbox{\scriptsize{--}}\mathrm{N}_{2}}^{*}$ of the non-Lewis orbital, and their subsequent impact on molecular stability and geometry (bond lengths) are also related to the resulting p character of the corresponding nitrogen NHO of the $\sigma_{\mathrm{N}_{3}\mbox{\scriptsize{--}}\mathrm{N}_{2}}$ bond orbital. In addition, the partial charge distribution on the skeletal atoms shows that the electrostatic repulsion or attraction between atoms can give a significant contribution to the intra- and intermolecular interaction. [ABSTRACT FROM AUTHOR]

The whole mol­ecule of the title compound, C19H14N4O2, is essentially planar, with a highly conjugated π system. In the crystal, the mol­ecules are packed as chains along the [011] direction connected by O-H⋯N intermolecular hydrogen bonds. [ABSTRACT FROM AUTHOR]

The title compound, C18H12N4O·H2O, adopts the keto tautomeric form and the azomethine C=N double bond is in the E configuration. The dihedral angle between the planes of the di­aza­fluorene moiety and the phenyl ring is 11.3 (1)°. In the solid state, the mol­ecules form infinite chain-like structures via O-H⋯N hydrogen bonds involving the water mol­ecules and di­aza­fluorene moieties. [ABSTRACT FROM AUTHOR]

The crystal structure of the title compound, C15H14N2O2·H2O, is in the keto tautomeric form and the configuration at the azomethine C=N double bond is E. The mol­ecule is non-planar, with a dihedral angle of 27.3 (1)° between the aromatic rings. The crystal structure is stabilized by extensive hydrogen bonding involving the water mol­ecule and hydrazone moiety. [ABSTRACT FROM AUTHOR]

The enantiomers of the anions of five alpha-hydroxy acids, namely lactic acid, alpha-hydroxybutyric acid, 2-hydroxycaproic acid, 2-hydroxyoctanoic acid and 2-hydroxydecanoic acid, as well as the two alpha-amino acids aspartic acid and glutamic acid, were baseline separated and detected by CE with contactless conductivity detection. Vancomycin was employed as chiral selector and could be used with conductivity detection without having to resort to a partial filling protocol as needed when this reagent is used with UV absorbance measurements. The procedure was successfully applied to the determination of the lactic acid enantiomers in samples of milk and yogurt. Linearity was achieved in the concentration range of 10-500 micromol/L with good correlation coefficients (0.9993 and 0.9990 for L- and D-lactic acid, respectively). The LODs (3 S/N) for L- and D-lactic acid were determined as 2.8 and 2.4 micromol/L, respectively.

Objective: To observe the relationship among amyloid beta-peptide (Abeta)-induced neurotoxicity, serum-inducible kinase (SNK)-spine-associated Rap guanosine triphosphatase activating protein (SPAR) pathway and N-methyl-D-aspartate receptor (NMDAR), and to explore the mechanism of the protective effect of spleen-yin nourishing recipe (Zibu Piyin Recipe, ZBPYR) in hippocampal neurons against Abeta-induced neurotoxicity., Methods: The Abeta(1-40) powder was dissolved in 1 x PBS and incubated at 37 degrees centigrade, and then aggregated fibrillar Abeta(1-40) was obtained 72 h later. We used rat primary hippocampal neurons as cell model. ZBPYR-containing serum was gained by the method of serum pharmacology. ZBPYR-containing serum was added to the culture 1 h before Abeta(1-40) (5 micromol/L) exposure. Cells were harvested 2 h after Abeta(1-40) exposure for total RNA extracting. Then the mRNA expression levels of SNK, SPAR and NMDAR subunits NR1, NR2A and NR2B were detected by reverse transcription-polymerase chain reaction (RT-PCR)., Results: After 2-hour Abeta(1-40) exposure, we found that the expression level of SNK mRNA was up-regulated and the expression levels of SPAR, NR1, NR2A and NR2B mRNAs were down-regulated in hippocampal neurons as compared with control group (P < 0.01, P < 0.05). While with ZBPYR-containing serum pretreatment, the expression level of SNK mRNA was down-regulated and the levels of SPAR, NR1, NR2A and NR2B were up-regulated as compared with Abeta(1-40) exposure, and 2% ZBPYR-containing serum showed the best effect (P < 0.05)., Conclusion: Abeta-induced neurotoxicity was related to SNK-SPAR pathway and NMDAR; ZBPYR-containing serum can protect neurons from Abeta-induced neurotoxicity, and this protective effect may be performed by regulating the expression of NMDAR and blocking of the SNK-SPAR pathway.