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Objective The construction of road pile-plate structures can significantly impact adjacent metro tunnels and railway structures. Under stringent regulatory requirements and complex engineering conditions, it is essential to ensure the safety of existing metro and railway structures. Method Based on the new Bai′an Highway project, numerical simulation methods are utilized to construct a Plaxis3D finite element calculation model. This model simulates various construction conditions to analyze the impact of pile-plate structure construction process on the adjacent existing metro and high-speed railway. Result & Conclusion The research results indicate that during the construction of bored cast-in-place piles in this road project, adverse conditions such as hole collapse and soil plug effect are likely to occur. These conditions can negatively impact adjacent metro lines, causing metro tunnel displacement and convergence deformation to exceed control values. In contrast, the construction process has less impact on high-speed railway bridges, with deformation remaining within controllable limits. Therefore, it is necessary to improve and optimize the road construction plan, such as increasing the distance between pile foundation and metro tunnels and extending the length of some piles. A safety assessment of the optimized design scheme is conducted, and subsequent numerical simulation results show that the metro tunnel displacement and deformation caused by road construction can meet the required standards, ensuring metro tunnel structural safety.

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In the method of survey underwater topography using remote sensing, and the water surface spectral reflectance R, which remote sensing inversion results were closely related to affects by the water and underwater sediment and other aspects, especially in shallow nearshore coastal waters, different sediment types significantly affected the reflectance changes. Therefore, it was of great significance of improving retrieval accuracy to explore the relation of sediment and water surface spectral reflectance. In this study, in order to explore relationship, we used intertidal sediment sand samples in Sheyang estuary, and in the laboratory measured and calculated the chroma indicators, and the water surface spectral reflectance. We found that water surface spectral reflectance had a high correlation with the chroma indicators; research result stated that the color of the sediment had an very important impact on the water surface spectral, especially in Red-Green chroma a*.Also, the research determined the sensitive spectrum bands of the Red-Green chroma a*, which were 636-617nm、 716-747nm and 770-792nm. [ABSTRACT FROM AUTHOR]

ETS variant transcription factor 4 (ETV4) is a common cancer-promoting transcription factor and its expression has been found to be significantly upregulated in glioblastoma multiforme (GBM), as determined via analysis of the Gene Expression Profiling Interactive Analysis (GEPIA) database. In addition, our previous study demonstrated that ETV4 expression was highly positively correlated with epithelial membrane protein 1 (EMP1). The present study aimed to determine whether ETV4 could influence the activation of the PI3K/AKT/mTOR signaling pathway to affect the autophagy and apoptosis of GBM cells by regulating the transcriptional activity of EMP1. In addition to the analysis of the GEPIA database, the expression levels of ETV4 were also investigated in several different GBM cell lines. After interfering with the expression of ETV4, western blotting was used to detect the expression levels of autophagy- and apoptosis-related proteins, and a TUNEL assay was used to detect the levels of cell apoptosis. Dual luciferase reporter and chromatin immunoprecipitation assays were used to verify the potential binding site of ETV4 on EMP1. Western blotting was also used to analyze the expression levels of PI3K/AKT/mTOR signaling pathway-related proteins. The results of the current study revealed that the expression levels of ETV4 were significantly upregulated in GBM cell lines compared with those in normal glial cells. In the GBM cell line, LN-229, ETV4 was discovered to bind to the EMP1 promoter and positively regulate the expression of EMP1. The knockdown of ETV4 expression inhibited the PI3K/AKT/mTOR signaling pathway activity to promote autophagy and apoptosis, and this effect could be partially reversed by overexpressing EMP1. In conclusion, these findings indicated that the knockdown of ETV4 in GBM cells may reduce the transcriptional activation of EMP1 and thereby inhibit PI3K/AKT/mTOR signaling pathway activity to promote autophagy and apoptosis. This provides a novel insight into potential strategies for the treatment of GBM via the induction of autophagy-dependent apoptosis. [ABSTRACT FROM AUTHOR]

Objective: To provide the clinical anatomic data of the lingual artery with 3D CT reconstruction., Method: Ten healthy subjects were recruited. Spiral CT scan ranged from the sternoclavicular joint to the lower edge of the orbit and the data was subjected to three-dimensional reconstruction. The distance from the origin of the lingual artery to the bifurcation of the common carotid artery and tip of the greater horn of hyoid bone were measured respectively and the distance between the midline of the lingual artery and the midline of tongue were also measured., Result: The horizontal distance between starting level of lingual artery to the level of the hyoid horn tip was (1.51 +/- 0.35) cm. The horizontal distance between the level of the lingual artery to the carotid bifurcation was (0.95 +/- 0.31) cm. The comparison of the distance from lingual artery 1 cm anterior or posterior to foramen cecum to midline of tongue showed (t = 45.27, P < 0.01) a statistically significant difference., Conclusion: The lingual artery could be demonstrated clearly in 3D reconstruction. To ensure the operative safety, the depth of radiofrequency for OSAHS at the tongue base should be limited within 2 centimeters.