Search

Your search keyword '"Gondo, Toshikazu"' showing total 322 results
Start Over Author "Gondo, Toshikazu"
322 results on '"Gondo, Toshikazu"'

10. A Histochemical, Immunohistochemical, Ultrastructural and Immunoelectron Microscopical Characterization of Cerebrovascular Amyloid and Diffuse Plaques in Autopsied Aged Dogs

Author

Ishihara, Tokuhiro, Gondo, Toshikazu, Takahashi, Mutsuo, Yokota, Tadaaki, Yamashita, Yoshimi, Uchino, Fumiya, Kajiyama, Matsuo, Ikeda, Shu-ichi, Allsop, David, Imai, Kohzoh, Natvig, Jacob B., editor, Førre, Øystein, editor, Husby, Gunnar, editor, Husebekk, Anne, editor, Skogen, Bjørn, editor, Sletten, Knut, editor, and Westermark, Per, editor

Published
1991
Full Text
View/download PDF

22. Transiently, paralleled upregulation of arginase and nitric oxide synthase and the effect of both enzymes on the pathology of asthma

Author

Takemoto, Kei, Ogino, Keiki, Shibamori, Masafumi, Gondo, Toshikazu, Hitomi, Yoshiaki, Takigawa, Tomoko, Wang, Da-Hong, Takaki, Jiro, Ichimura, Hiroshi, Fujikura, Yoshihisa, and Ishiyama, Hironobu

Subjects
Arginase -- Health aspects, Arginase -- Research, Enzymes -- Health aspects, Enzymes -- Research, Lungs -- Health aspects, Lungs -- Research, Biological sciences
Abstract

Changes in the expression of arginase and their association with nitrosative stress were investigated using an asthmatic model previously established in NC/Nga mice with mite extract. Mite crude extract (100 [micro]g/day) from Dermatophagoides farinae was administered intranasally for 5 consecutive days (day 0-4), and a single challenge was performed on day 11. On day 12, upregulation of the mRNA expression of inducible types of nitric oxide synthase (iNOS) and increases in immunohistochemical staining for iNOS and nitrotyrosine were observed. However, the level of nitrite nitrate was unchanged. An increase in enzymatic activity, upregulation of mRNA expression, and immunostaining for arginase I was detected in the lung tissue and serum. Moreover, increases in both arginase I and II were revealed by immunoblotting. Goblet cell hyperplasia in bronchial epithelial cells and increasing collagen synthesis around the bronchus were also observed. These results suggested that an increase in arginase may lead to decreased availability of arginine for nitric oxide synthase and may contribute to the remodeling of the lung. NC/Nga; mite; reactive nitrogen species; airway remodeling

Published
2007

47. Effective Treatment of a Malignant Breast Phyllodes Tumor with Doxorubicin-Ifosfamide Therapy

Author

Yamamoto, Shinya, Yamagishi, Shigeru, Kohno, Toshiro, Tajiri, Ryosuke, Gondo, Toshikazu, Yoshimoto, Noboru, and Kusano, Nobuko

Subjects
Article Subject, respiratory system, respiratory tract diseases
Abstract

Malignant phyllodes tumors of the breast occur infrequently and are difficult to treat with chemotherapy. Here, we present an effective chemotherapy strategy for recurrent malignant breast phyllodes tumors. A 48-year-old woman was diagnosed with a malignant phyllodes tumor in her right breast and underwent total right mastectomy. One year later, the tumor recurred in the right (a 2.2 cm mass) and left (a 10 cm mass) lungs; pleural effusion was also observed in the left lung. Eight courses of doxorubicin-ifosfamide (AI) therapy were administered. After treatment, the right lung mass and pleural effusion regressed completely and the left lung mass regressed to 2 cm. In conclusion, AI therapy is useful for treating recurrent malignant breast phyllodes tumors.

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results