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Supplemental material, DS_10.1177_0363546519869673 for The Number of Injury Events Associated With the Critical Size of Bipolar Bone Defects in Rugby Players With Traumatic Anterior Shoulder Instability by Yoshinori Hasegawa, Takayuki Kawasaki, Shuko Nojiri, Shogo Sobue, Takefumi Kaketa, Yoshinori Gonda, Yoshiaki Itoigawa and Kazuo Kaneko in The American Journal of Sports Medicine

Spherical beta-tricalcium phosphate (β-TCP) granules synthesized using a unique dropping slurry method expressed good osteoconductivity with prominent bone apposition and bioresorbability when implanted into the rat femur (Gonda et al, Key Eng. Mater. 361-363:1013-1016, 2008). The spherical β-TCP granules were implanted into the bone defect created in the distal end of the right femur of each 8-week-old female Wistar rat. To analyze performance of the spherical β-TCP granules as bone substitute in the bone with reduction in osteogenic potential, the right sciatic neurectomy was performed after implantation and the right hind limb was kept unloaded for 2 weeks before euthanization. Four weeks after implantation, some spherical β-TCP granules with resorption in part were surrounded by newly formed bone. Eight and 12 weeks after implantation, most of the residual β-TCP granules were embedded in newly formed bone, and total volume of the implant and newly formed bone was more than the other portions of the bone or the bone of control animals. Osteoclast activity in the implanted area was also higher than the other portions of the bone or the bone of control animals. Replacement of the intraosseous residual β-TCP granules for bone progressed at 12 weeks after implantation compared to those at 8 weeks after implantation. These data suggested that the spherical β-TCP granules stimulated osteogenesis and osteoclast activity of the unloaded bone., Key Engineering Materials, 396-398, pp.253-256; 2009

第25回宇宙利用シンポジウム(2009年1月14日-15日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス), The Twenty-fifth Space Utilization Symposium (January 14-15, 2009: ISAS/JAXA Sagamihara, Japan), Osteoclast plays pivotal roles in bone metabolism. However, details of osteoclast activity in low gravity remain unknown. We have developed a unique osteoclast culture system using biodegradable and unbiodegradable ceramic discs. Using an ultrasensitive intracellular calcium analyzing system, we are studying change in intracellular calcium of active osteoclasts cultured on biodegradable ceramics and quiescent osteoclasts cultured on unbiodegradable ceramics. It is highly possible that low gravity changes function of calcium channels in osteoclasts and will change the intracellular calcium concentration very quickly. It has been shown that intracellular calcium affects osteoclast bioactivity. Hence, parabolic flight experiments will be able to clarify the mystery of osteoclast in space medical biology., 形態: カラー図版あり, 資料番号: AA0064297047