109 results on '"Gonda, H."'
Search Results
2. Microbial communities in feed, bedding material, and bulk milk: Experiences from a feeding trial
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Eliasson, T., Sun, L., Lundh, Å., Gonda, H., Höjer, A., Hallin Saedén, K., and Hetta, M.
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- 2024
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Catalog
3. O34 Providing fresh pasture in the evening for fulltime grazing dairy cows increased energy corrected milk yield
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Ternman, E., primary, Lardy, Q., additional, Danielsson, R., additional, and Gonda, H., additional
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- 2023
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4. Effect of background noise on food perception
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Woods, A.T., Poliakoff, E., Lloyd, D.M., Kuenzel, J., Hodson, R., Gonda, H., Batchelor, J., Dijksterhuis, G.B., and Thomas, A.
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- 2011
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5. Influence of leukotriene pathway polymorphisms on clinical responses to montelukast in Japanese patients with asthma
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Kotani, H., Kishi, R., Mouri, A., Sashio, T., Shindo, J., Shiraki, A., Hiramatsu, T., Iwata, S., Taniguchi, H., Nishiyama, O., Iwata, M., Suzuki, R., Gonda, H., Niwa, T., Kondo, M., Hasegawa, Y., Kume, H., and Noda, Y. more...
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- 2012
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6. CBDCA + PEMETREXED + BEVACIZUMAB AND ITS MAINTENANCE CHEMOTHERAPY AS A SECOND LINE IN A CASE OF SOLE BREAST METASTASIS FROM LUNG ADENOCARCINOMA AFTER COMPLETE RESPONSE BY GEFITINIB AS A FIRST-LINE CHEMOTHERAPY
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Sato, K., Yoshihara, M., Takeyama, Y., Yogo, N., Ohdate, M., Fukui, Y., Gonda, H., and Suzuki, R.
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- 2012
7. Malignant lymphoma detected by screening program with esophagogastroduodenoscopy of one private screening center in Japan
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Nakamura, T., primary, Ikeda, M., additional, Shibata, S., additional, Kon, Y., additional, Konuma, K., additional, Sanada, T., additional, Gonda, H., additional, Suto, Y., additional, Kobayashi, K., additional, Tamura, H., additional, Kobayashi, M., additional, Hasegawa, A., additional, Amagasa, Y., additional, Suzuki, A., additional, Fukuda, M., additional, Aoyagi, C., additional, Matsuura, N., additional, Kawashima, Y., additional, Shimura, M., additional, and Takita, N., additional more...
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- 2018
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8. Gastric cancer detected after Helicobacter pylori eradication at one private screening center in Japan
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Nakamura, T., primary, Kon, Y., additional, Konuma, K., additional, Sanada, T., additional, Shibata, S., additional, Gonda, H., additional, Suto, Y., additional, Amagasa, Y., additional, Suzuki, A., additional, Fukuda, M., additional, and Aoyagi, C., additional more...
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- 2017
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9. Duodenal neoplasm in screening esophagogastroduodenoscopy
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Nakamura, T., primary, Kon, Y., additional, Shibata, S., additional, Konuma, K., additional, Sanada, T., additional, Gonda, H., additional, Suto, Y., additional, Kobayashi, K., additional, Takita, N., additional, Shimura, M., additional, Yoshida, H., additional, Suzuki, A., additional, Onuki, S., additional, Fukuda, M., additional, Aoyagi, C., additional, Hasegawa, Y., additional, and Nishiwaki, A., additional more...
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- 2016
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10. 1596P - Malignant lymphoma detected by screening program with esophagogastroduodenoscopy of one private screening center in Japan
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Nakamura, T., Ikeda, M., Shibata, S., Kon, Y., Konuma, K., Sanada, T., Gonda, H., Suto, Y., Kobayashi, K., Tamura, H., Kobayashi, M., Hasegawa, A., Amagasa, Y., Suzuki, A., Fukuda, M., Aoyagi, C., Matsuura, N., Kawashima, Y., Shimura, M., and Takita, N. more...
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- 2018
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11. Nitrogen balance in Holstein steers grazing winter oats: effect of nitrogen fertilisation
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Chopa, F. Sánchez, primary, Nadin, L. B., additional, Agnelli, L., additional, Trindade, J. K., additional, and Gonda, H. L., additional
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- 2016
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12. 1413P - Gastric cancer detected after Helicobacter pylori eradication at one private screening center in Japan
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Nakamura, T., Kon, Y., Konuma, K., Sanada, T., Shibata, S., Gonda, H., Suto, Y., Amagasa, Y., Suzuki, A., Fukuda, M., and Aoyagi, C.
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- 2017
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13. 1330P - Duodenal neoplasm in screening esophagogastroduodenoscopy
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Nakamura, T., Kon, Y., Shibata, S., Konuma, K., Sanada, T., Gonda, H., Suto, Y., Kobayashi, K., Takita, N., Shimura, M., Yoshida, H., Suzuki, A., Onuki, S., Fukuda, M., Aoyagi, C., Hasegawa, Y., and Nishiwaki, A. more...
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- 2016
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14. Nitrogen balance in Holstein steers grazing winter oats: effect of nitrogen fertilisation.
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Sánchez Chopa, F., Nadin, L. B., Agnelli, L., Trindade, J. K., and Gonda, H. L.
- Abstract
The present study evaluated the effect of nitrogen (N) fertilisation of winter oats on whole-animal N balance (N intake, N excretion in urine and faeces, N retention), partition of urinary N (purine-N derivatives and urea-N) and average daily gain (ADG) in grazing steers. The experimental area was divided in two plots (10 steers/plot), and samples were obtained in two periods (one plot/period).The experimental area was divided in two plots, and each plot in 10 strips. Twenty Holstein steers (161.3±7 kg of initial bodyweight) grazed, for 51 days, individual strips of fertilised (100 kg N/ha; N100) and non-fertilised (N0) winter oats during daylight (10 h/day). The daily individual grazing paddock was adjusted to offer 6 kg DM of green leaf·100 kg/BW.day. Chemical composition of the herbage and N diurnal variation were estimated by collecting three samples per paddock at 0830 hours, 1330 hours and 1830 hours, twice on each sampling period. Forage intake and in vivo digestibility were estimated by the n-alkane technique. Individual N intake was estimated using n-alkane data, the ingestive behaviour data and the diurnal variation of the chemical composition of the forage. N fertilisation increased N content [P < 0.01; N0 = 11.4% crude protein (CP) vs N100 = 13.9% CP] and decreased the water-soluble carbohydrate content (P < 0.01; N0 = 21.1% vs N100 = 16.8%) in the forage, but did not modify herbage mass or the DM content. Dry matter intake (4.72 kg DM/day), water intake (7.57 L/day) and DM digestibility (67%) were not affected by N fertilisation. However, N intake and N digestibility were higher in N100 than in N0 (20 vs 7 g N/day). Although treatments had similar faecal N excretions (average 45.4 g N/day), there was a trend to increase urinary N excretion with N intake (P = 0.08; N100 = 53.3 vs N0 = 47.5 g N/day), a trend to increase N-allantoin excretion (P = 0.11; N100 = 3.18 vs N0 = 2.91 g/day) and an increase in urea-N excretion (P < 0.01; N100 = 30.7 vs N0 = 23.8 g/day). IncreasingNintake led to greaterNretention (P<0.02;N100=37.9 vsN0=20.9 g N/day) andADG(P<0.03;N100=860 vs N0 = 698 g/day). These results suggest that fertilising winter oats with 100 kg N/ha improves N retention and ADG in young steers under grazing conditions. [ABSTRACT FROM AUTHOR] more...
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- 2016
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15. Influence of leukotriene pathway polymorphisms on clinical responses to montelukast in Japanese patients with asthma
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Kotani, H., primary, Kishi, R., additional, Mouri, A., additional, Sashio, T., additional, Shindo, J., additional, Shiraki, A., additional, Hiramatsu, T., additional, Iwata, S., additional, Taniguchi, H., additional, Nishiyama, O., additional, Iwata, M., additional, Suzuki, R., additional, Gonda, H., additional, Niwa, T., additional, Kondo, M., additional, Hasegawa, Y., additional, Kume, H., additional, and Noda, Y., additional more...
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- 2011
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16. Role of Cell Death Ligand and Receptor System on Regulation of Follicular Atresia in Pig Ovaries
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Manabe, N, primary, Matsuda-Minehata, F, additional, Goto, Y, additional, Maeda, A, additional, Cheng, Y, additional, Nakagawa, S, additional, Inoue, N, additional, Wongpanit, K, additional, Jin, H, additional, Gonda, H, additional, and Li, J, additional more...
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- 2008
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17. Spontaneous decapitation of a small colorectal cancer: follow-up of the spontaneous course
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Tomiki, Y., primary, Gonda, H., additional, Seki, E., additional, Maeda, T., additional, and Kitamura, D., additional
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- 2007
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18. A phase II trial of concurrent radiochemotherapy with carboplatin (CBDCA) and weekly docetaxel (TXT) in locally advanced non-small cell lung cancer (NSCLC)
- Author
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Suzuki, R., primary, Taniguchi, H., additional, Kondoh, Y., additional, Shindoh, J., additional, Matsumoto, S., additional, Hiramatsu, T., additional, Gonda, H., additional, Baba, K., additional, Hasegawa, Y., additional, and Shimokata, K., additional more...
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- 2004
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19. Portal net appearance of amino acids in growing pigs fed a barley-based diet with inclusion of three different forage meals
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Reverter, M., primary, Lundh, T., additional, Gonda, H. L., additional, and Lindberg, J. E., additional
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- 2000
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20. P2-007 - CBDCA + Pemetrexed + Bevacizumab and its Maintenance Chemotherapy as a Second Line in a Case of Sole Breast Metastasis from Lung Adenocarcinoma after Complete Response by Gefitinib as a First-Line Chemotherapy
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Sato, K., Yoshihara, M., Takeyama, Y., Yogo, N., Ohdate, M., Fukui, Y., Gonda, H., and Suzuki, R.
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- 2012
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21. Heritable translocations induced by dermal exposure of male mice to acrylamide.
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Adler, I. -D., Gonda, H., de Angelis, M. Hrabé, Jentsch, I., Otten, I. S., and Speicher, M. R.
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ACRYLAMIDE , *CHROMOSOMAL translocation , *GENOMICS , *CYTOGENETICS , *MOLECULAR genetics , *GENETIC research , *ANIMAL models in research - Abstract
Acrylamide (AA) is an important industrial chemical used mainly in the production of polymers. It can be absorbed through the skin. AA was shown to be a germ cell clastogen that entails a genetic risk for exposed workers. The genetic risk calculation was based on mouse heritable translocation test data obtained after acute intraperitoneal (ip) exposure (Adler et al., 1994). To obtain a correction factor between ip and dermal exposure, dominant lethal and heritable translocation tests were carried out with dermal exposure of male mice to AA. In the dominant lethal test, male (102/El × C3H/El)F1 mice were exposed by dermal application to the shaved backs of 50 mg/kg AA per day on five consecutive days or to five daily ip injections of 50 mg/kg AA. One day after the end of exposure, the males were mated to untreated females of the same hybrid stock for four days and females were changed every four days for a total of five matings. Dominant lethal effects were found during matings 1–3. For ip exposure, these values were 81.7, 85.7 and 45.4%, respectively; for dermal exposure the corresponding values were 22.1, 30.6 and 16.5%, respectively. In the heritable translocation assay, male C3H/El mice were treated with five dermal exposures of 50 mg/kg AA and mated 1.5–8.5 days after the end of exposure to untreated female 102/El mice. Pregnant females were allowed to come to term and all offspring were raised to maturity. Translocation carriers among the F1 progeny were selected by a sequential fertility testing and cytogenetic analysis including G-band karyotyping and M-FISH. A total of 475 offspring were screened and 41 translocation carriers were identified. The observed translocation frequency after dermal exposure was 8.6% as compared to 21.9% after similar ip exposure (Adler, 1990). The calculated ratio of ip vs. dermal exposure of 0.39 can be applied to obtain a more realistic calculation of genetic risk for dermally exposed workers. Copyright © 2003 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] more...
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- 2004
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22. 1-Aminobenzotriazole inhibits acrylamide-induced dominant lethal effects in spermatids of male mice.
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Adler, I.-D., Baumgartner, A., Gonda, H., Friedman, M.A., and Skerhut, M.
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LABORATORY mice ,GERM cells ,MUTAGENS ,PROTAMINES ,EPOXY compounds - Abstract
Acrylamide (AA) is a germ cell mutagen and induces clastogenic effects predominantly in spermatids of mice. The mechanism of AA clastogenicity has been a matter of dispute. Since the reactivity of AA with DNA is low but is high with proteins containing SH groups, it was suggested that protamine alkylation could be the mechansim of clastogenicity by AA in spermatids. This was substantiated by the observation that the time course of protamine alkylation and dominant lethal effects in spermatids of mice induced by AA was strictly parallel. Another suggestion was that AA may be metabolized by cytochrome P-450 to the epoxide glycidamide (GA), which is then the ultimate DNA-reactive clastogen. This suggestion was based on the similarity of the stage specificity pattern for dominant lethality and heritable translocation induction by AA and GA. To test this latter assumption, 1-aminobenzotriazole (ABT), an inhibitor of P-450 metabolism, was used in the present experiments. Male mice were pretreated with ABT (3×50 mg/kg) on three consecutive days followed by AA treatment (125 mg/kg) on day 4. Parallel groups of animals were treated with AA (125 mg/kg), ABT (3×50 mg/kg) or with the solvent double-distilled water. The experiment was repeated once with slightly varied mating parameters. The results of both experiments showed that ABT inhibited or significantly reduced the AA-induced dominant lethal effects. Thus, the present data support the hypothesis that the AA metabolite GA is the ultimate clastogen in mouse spermatids. [ABSTRACT FROM PUBLISHER] more...
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- 2000
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23. Targeting of Krüppel-associated box-containing zinc finger proteins to centromeric heterochromatin. Implication for the gene silencing mechanisms.
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Matsuda, E, Agata, Y, Sugai, M, Katakai, T, Gonda, H, and Shimizu, A
- Abstract
Krüppel-associated box-containing zinc finger proteins (KRAB-ZFPs) repress transcription via functional interaction with the corepressor KRAB-associated protein-1 (KAP-1). KAP-1 directly interacts with heterochromatin protein 1 (HP1), a dose-dependent regulator of heterochromatin-mediated silencing. Here we show that two KRAB-ZFPs that we previously identified, KRAZ1 and KRAZ2, are targeted to foci of centromeric heterochromatin containing HP1alpha through the interaction with KAP-1. Centromeric targeting potential of KRAZ1 and KAP-1 is strictly correlated with their silencing activities; a KRAB mutant of KRAZ1 that is unable to bind KAP-1 and KAP-1 deletions unable to bind HP1 cannot localize to centromeric foci nor repress transcription. We provide evidence that this correlation is likely to be functionally relevant. First, overexpression of the VP16 transactivation domain fused with the KAP-1 deletion that binds to KRAB but not to HP1 leads to dramatic redistribution of KRAZ1 from centromeric foci and simultaneously converts KRAZ1-mediated silencing into strong transcriptional activation. Second, a specific inhibitor of histone deacetylases, trichostatin A, effectively redistributes KRAZ1 and KAP-1 from centromeric foci and partially relieves their silencing activities. These data strongly suggest that KRAB-ZFPs/KAP-1 silence transcription by dynamic recruitment of the target locus to the specific gene silencing compartment, centromeric heterochromatin, in a histone deacetylase-dependent manner. more...
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- 2001
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24. DNA polymerase b is not essential for the formation of palindromic (P) region of T cell receptor gene
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Gonda, H., Sugai, M., Katakai, T., Sugo, N., Aratani, Y., Koyama, H., Mori, K. J., and Shimizu, A.
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- 2001
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25. The effect of roughage to concentrate ratio in the diet on nitrogen and purine metabolism in dairy cows
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Gonda, H. L., Emanuelson, M., and Murphy, M.
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- 1996
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26. Dose response study for 1,3-butadiene-induced dominant lethal mutations and heritable translocations in germs cells of male mice
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Adler, I.-D., Filser, J., Gonda, H., and Schriever-Schwemmer, G.
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- 1998
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27. The dissociation constant of verapamil estimated from its effect on Ca concentration-tension curves in guinea-pig tracheal muscle
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Gonda, H., Baba, K., Satake, T., Takagi, K., and Tomita, T.
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- 1988
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28. CLINICAL STUDY OF THE PANCREATOSCOPE (BABY SCOPE) FOR PANCREATIC DISEASES.
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HAYASHIDA, Y., SHIMIZU, T., MIZOBUCHI, N., GONDA, H., MAEKAWA, T., and SAKAKIBARA, N.
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- 1992
29. Models to predict nitrogen excretion from beef cattle fed a wide range of diets compiled from South America.
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Souza VC, Congio GFS, Rodrigues JPP, Valadares Filho SC, Silva FAS, Rennó LN, Reis RA, Cardoso AS, Rodrigues PHM, Berchielli TT, Messana JD, Cajarville C, Granja-Salcedo YT, Borges ALCC, Kozloski GV, Rosero-Noguera JR, Gonda H, Hristov AN, and Kebreab E more...
- Abstract
The objective of this meta-analysis was to develop and evaluate models for predicting nitrogen (N) excretion in feces, urine, and manure in beef cattle in South America. The study incorporated a total of 1,116 individual observations of N excretion in feces and 939 individual observations of N excretion in feces and in urine (g/d), representing a diverse range of diets, animal genotypes, and management conditions in South America. The dataset also included data on dry matter intake ( DMI ; kg/d) and nitrogen intake ( NI ; g/d), concentrations of dietary components, as well as average daily gain ( ADG ; g/d) and average body weight ( BW ; kg). Models were derived using linear mixed-effects regression with a random intercept for the study. Fecal N excretion was positively associated with DMI, NI, nonfibrous carbohydrates, average BW, and ADG and negatively associated with EE and CP concentration in the diet. The univariate model predicting fecal N excretion based on DMI (model 1) performed slightly better than the univariate model, which used NI as a predictor variable (model 2) with a root mean square error ( RMSE ) of 38.0 vs. 39.2%, the RMSE-observations SD ratio (RSR) of 0.81 vs. 0.84, and concordance correlation coefficient ( CCC ) of 0.53 vs. 0.50, respectively. Models predicting urinary N excretion were less accurate than those derived to predict fecal N excretion, with an average RMSE of 43.7% vs. 37.0%, respectively. Urinary and manure N excretion were positively associated with DMI, NI, CP, average BW, and ADG and negatively associated with neutral detergent fiber concentration in the diet. As opposed to fecal N excretion, the univariate model predicting urinary N excretion using NI (model 10) performed slightly better than the univariate model using DMI (model 9) as predictor variable with an RMSE of 36.0% vs. 39.7%, RSR 0.85 vs. 0.93, and CCC of 0.43 vs. 0.29, respectively. The models developed in this study are applicable for predicting N excretion in beef cattle across a broad spectrum of dietary compositions and animal genotypes in South America. The univariate model using DMI as a predictor is recommended for fecal N prediction, while the univariate model using NI is recommended for predicting urinary and manure N excretion because the use of more complex models resulted in little to no benefits. However, it may be more useful to consider more complex models that incorporate nutrient intakes and diet composition for decision-making when N excretion is a factor to be considered. Three extant equations evaluated in this study have the potential to be used in tropical conditions typical of South America to predict fecal N excretion with good precision and accuracy. However, none of the extant equations are recommended for predicting urine or manure N excretion because of their high RMSE, and low precision and accuracy., Competing Interests: The authors report no conflicts of interest., (© The Author(s) 2024. Published by Oxford University Press on behalf of the American Society of Animal Science.) more...
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- 2024
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30. Epiphytic microbiota in Swedish grass-clover herbage and the effect of silage additives on fermentation profiles and bacterial community compositions of the resulting silages.
- Author
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Eliasson T, Sun L, Lundh Å, Höjer A, Saedén KH, Hetta M, and Gonda H
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- Fermentation, RNA, Ribosomal, 16S genetics, Sweden, Medicago, Poaceae, Silage, Microbiota
- Abstract
Aims: To investigate the epiphytic microbiota in grass-clover herbage harvested at different sites and occasions and to explore the effect of different silage additives on the resulting silage microbiota., Methods and Results: Herbage was harvested from grass-clover leys at geographically distributed sites in a long-term field experiment in Sweden, in early and late season of two consecutive years. Different silages were made from the herbage using: (1) no additive, (2) acid-treatment, and (3) inoculation by starter culture. Herbages were analysed for botanical and chemical composition, and the resulting silages for products of fermentation. Bacterial DNA was extracted from herbage and silage samples, followed by sequencing using Illumina 16S rRNA amplicon sequencing. Herbage microbiota showed no clear correlation to site or harvesting time. Silage additives had a major effect on the ensiling process; inoculation resulted in well fermented silages comprising a homogenous microbiota dominated by the genera Lactobacillus and Pediococcus. A minor effect of harvest time was also observed, with generally a more diverse microbiota in second-harvest silages. Untreated silages showed a higher relative abundance (RA) from non-lactic acid bacteria compared to acid-treated silages. In most silages, only a few bacterial amplicon sequence variants contributed to most of the RA., Conclusions: The epiphytic microbiota in grass-clover herbage were found to be random and not dependent on site. From a microbial point of view, the most predictable and preferable silage outcome was obtained by inoculation with a starter culture. Acid-treatment with formic- and propionic acid surprisingly resulted in a less preferable silage. Silage making without additives cannot be recommended based on our results., (© The Author(s) 2023. Published by Oxford University Press on behalf of Applied Microbiology International.) more...
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- 2023
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31. Improving the accuracy of beef cattle methane inventories in Latin America and Caribbean countries.
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Congio GFS, Bannink A, Mayorga OL, Rodrigues JPP, Bougouin A, Kebreab E, Carvalho PCF, Berchielli TT, Mercadante MEZ, Valadares-Filho SC, Borges ALCC, Berndt A, Rodrigues PHM, Ku-Vera JC, Molina-Botero IC, Arango J, Reis RA, Posada-Ochoa SL, Tomich TR, Castelán-Ortega OA, Marcondes MI, Gómez C, Ribeiro-Filho HMN, Gere JI, Ariza-Nieto C, Giraldo LA, Gonda H, Cerón-Cucchi ME, Hernández O, Ricci P, and Hristov AN more...
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- Animals, Cattle, Latin America, Diet veterinary, Eating, Methane, Animal Feed analysis
- Abstract
On-farm methane (CH
4 ) emissions need to be estimated accurately so that the mitigation effect of recommended practices can be accounted for. In the present study prediction equations for enteric CH4 have been developed in lieu of expensive animal measurement approaches. Our objectives were to: (1) compile a dataset from individual beef cattle data for the Latin America and Caribbean (LAC) region; (2) determine main predictors of CH4 emission variables; (3) develop and cross-validate prediction models according to dietary forage content (DFC); and (4) compare the predictive ability of these newly-developed models with extant equations reported in literature, including those currently used for CH4 inventories in LAC countries. After outlier's screening, 1100 beef cattle observations from 55 studies were kept in the final dataset (∼ 50 % of the original dataset). Mixed-effects models were fitted with a random effect of study. The whole dataset was split according to DFC into a subset for all-forage (DFC = 100 %), high-forage (94 % ≥ DFC ≥ 54 %), and low-forage (50 % ≥ DFC) diets. Feed intake and average daily gain (ADG) were the main predictors of CH4 emission (g d-1 ), whereas this was feeding level [dry matter intake (DMI) as % of body weight] for CH4 yield (g kg-1 DMI). The newly-developed models were more accurate than IPCC Tier 2 equations for all subsets. Simple and multiple regression models including ADG were accurate and a feasible option to predict CH4 emission when data on feed intake are not available. Methane yield was not well predicted by any extant equation in contrast to the newly-developed models. The present study delivered new models that may be alternatives for the IPCC Tier 2 equations to improve CH4 prediction for beef cattle in inventories of LAC countries based either on more or less readily available data., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier B.V. All rights reserved.) more...- Published
- 2023
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32. Impact of chest subcutaneous fat on the occurrence of central venous port-related infectious complications in cancer patients.
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Shibata J, Kawamura H, Hiramatsu K, Honda M, Shibata Y, Aoba T, Fujii M, Arimoto A, Ito A, Ishii K, Omiya K, Asai M, Arakawa T, Gonda H, Asai S, Hasegawa T, Kawashima K, and Kato T
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- Aged, Catheters, Indwelling, Cohort Studies, Female, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Subcutaneous Fat diagnostic imaging, Catheterization, Central Venous adverse effects, Neoplasms drug therapy, Prosthesis-Related Infections etiology
- Abstract
Purpose: There is no concrete evidence to support the association between the amount of subcutaneous fat area (SFA) in the central venous port-insertion site (precordium) and port-related complications. We aimed to investigate the relationship between SFA in the midclavicular line and postoperative infectious complications in patients undergoing port-insertion surgery., Methods: This was a single-institute and historical cohort study of 174 patients who underwent first central venous port implantation surgery for chemotherapy between January 2014 and December 2018. SFA in the midclavicular line was measured using preoperative computed tomography scans. The patients were divided into three groups according to SFA amount tertiles, and we investigated the association of SFA with infectious and all-cause complication events within 1 year., Results: Within a median follow-up of 306 days, the patients with intermediate SFA had significantly higher infection-free survival than those with low and high SFA (low vs. intermediate vs. high: 80.4% vs. 97.7% vs. 83.4%, respectively, p=0.034). In contrast, there was no significant difference in the overall complication-free survival among the groups (low vs. intermediate vs. high: 80.4% vs. 88.9% vs. 81.8%, respectively, p=0.29). Low SFA was independently associated with high risk of infectious complications (hazard ratio, 9.45; 95% confidence interval, 1.07-83.22, p=0.043)., Conclusion: Low SFA in the midclavicular line was an independent risk factor for infectious complications in the chemotherapy setting. This practical indicator can be useful for optimizing patients' nutritional status and when considering other types of vascular access to support administration of intravenous chemotherapy., (© 2021. The Author(s).) more...
- Published
- 2021
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33. Ruptured intra-abdominal testicular seminoma with hemorrhage shock, after inadequate surgical exploration for undescended testis: a case report.
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Gonda H, Saito T, Osawa T, Kurahashi S, Matsumura T, Fukami Y, Komatsu S, Kaneko K, Hiramatsu K, Kato T, and Sano T
- Abstract
Background: Undescended testes are associated with an increased risk of malignancy and infertility, and surgical treatment in childhood is recommended., Case Presentation: A 35-year-old man presented to the emergency department with abdominal pain and vomiting. Despite a history of surgery for a left undescended testis in infancy, his left-sided scrotum appeared underdeveloped. Contrast-enhanced computed tomography showed a pelvic mass, involving a major axis of approximately 15 cm, with high-density ascites suggestive of hemorrhage. A ruptured gastrointestinal stromal tumor was suspected. As he was in hemorrhagic shock, an emergency laparotomy was indicated. The active bleeding mass was controlled through complete resection. A pathological evaluation of the mass revealed a seminoma arising from an undescended testis. His post-operative course was uneventful, and he was discharged on post-operative day 6. Recurrence on the retroperitoneal lymph nodes was detected 1 year postoperatively, and a retroperitoneal lymph node dissection was performed after chemotherapy. He remains well without any apparent signs of recurrence., Conclusions: Paying close attention to an empty scrotum is advisable, even postoperatively, for undescended testis because of possible subsequent potential malignancy presenting with hemorrhage, as our patient demonstrated. more...
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- 2021
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34. A novel Killian-Jamieson diverticulectomy using a thyroid gland flap: a case report.
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Saito T, Ogawa T, Kurahashi S, Okamoto H, Gonda H, Matsumura T, Osawa T, Fukami Y, Komatsu S, Kaneko K, and Sano T
- Abstract
Background: A Killian-Jamieson diverticulum is a rare pharyngoesophageal diverticulum that is radically treated by diverticulectomy. However, there is no consensus on whether cricopharyngeal myotomy is necessary, and the optimal surgical methods that prevent postoperative complications such as leakage are undetermined., Case Presentation: A 49-year-old man was referred to our hospital with oropharyngeal dysphagia while eating. The patient was preoperatively diagnosed with a Killian-Jamieson diverticulum based on radiographic and clinical findings and underwent a transcervical diverticulectomy. The recurrent laryngeal nerves were preserved using an intraoperative nerve monitoring system, and the diverticulum was identified without difficulty. A partial cricopharyngeal myotomy was performed to expose the base of the diverticulum. The diverticulum was transected transversally using a linear stapler under the guidance of intraoperative upper intestinal endoscopy. A thyroid gland flap supplied by the superior thyroid artery was harvested and placed overlapping the area of the partial cricopharyngeal myotomy. Due to the proximity of the recurrent laryngeal nerve course to the diverticulum stump, the staple line was not buried with sutures. The thyroid gland flap with its rich vascular supply was fixed to completely cover the staple line on the cut surface of the thyroid gland. The postoperative course was uneventful, without vocal cord paralysis. The patient was discharged on postoperative day 8. He developed no clinical signs suggesting leakage, recurrence, or adverse events., Conclusion: Killian-Jamieson diverticulectomy using a thyroid gland flap and partial cricopharyngeal myotomy is a valid treatment option that may prevent complications and recurrence. Precise evaluation of the diverticulum using an intraoperative nerve monitoring system is crucial for the repair. more...
- Published
- 2020
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35. Primary cardiac angiosarcoma resection and reconstruction with pedicled autologous pericardium: A case report.
- Author
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Gonda H, Nakayama M, Toyama M, and Kato T
- Abstract
Introduction: Primary cardiac angiosarcoma is rare, and its prognosis remains poor. Complete surgical resection is the first choice among the available treatments, to ensure prolonged patient survival., Presentation of Case: We report the case of a 72-year-old man with right atrial angiosarcoma who presented with bloody pericardial effusion due to tumor hemorrhaging. Emergency surgery was performed. The right atrial free wall and vena cava were reconstructed with pedicled autologous pericardium. The patient died 12 months later because of multiple organ failure due to metastasis. Autopsy showed a maintained right atrial chamber and only mild calcification., Discussion: Pedicled autologous pericardium may have contributed to preserving cardiac function that could withstand chemotherapy and radiotherapy., Conclusion: Pedicled autologous pericardium was found to be useful for reconstructing the cardiac chamber after removal of a cardiac tumor., (Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.) more...
- Published
- 2020
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36. Methane Production in Dairy Cows Correlates with Rumen Methanogenic and Bacterial Community Structure.
- Author
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Danielsson R, Dicksved J, Sun L, Gonda H, Müller B, Schnürer A, and Bertilsson J
- Abstract
Methane (CH
4 ) is produced as an end product from feed fermentation in the rumen. Yield of CH4 varies between individuals despite identical feeding conditions. To get a better understanding of factors behind the individual variation, 73 dairy cows given the same feed but differing in CH4 emissions were investigated with focus on fiber digestion, fermentation end products and bacterial and archaeal composition. In total 21 cows (12 Holstein, 9 Swedish Red) identified as persistent low, medium or high CH4 emitters over a 3 month period were furthermore chosen for analysis of microbial community structure in rumen fluid. This was assessed by sequencing the V4 region of 16S rRNA gene and by quantitative qPCR of targeted Methanobrevibacter groups. The results showed a positive correlation between low CH4 emitters and higher abundance of Methanobrevibacter ruminantium clade. Principal coordinate analysis (PCoA) on operational taxonomic unit (OTU) level of bacteria showed two distinct clusters ( P < 0.01) that were related to CH4 production. One cluster was associated with low CH4 production (referred to as cluster L) whereas the other cluster was associated with high CH4 production (cluster H) and the medium emitters occurred in both clusters. The differences between clusters were primarily linked to differential abundances of certain OTUs belonging to Prevotella . Moreover, several OTUs belonging to the family Succinivibrionaceae were dominant in samples belonging to cluster L. Fermentation pattern of volatile fatty acids showed that proportion of propionate was higher in cluster L, while proportion of butyrate was higher in cluster H. No difference was found in milk production or organic matter digestibility between cows. Cows in cluster L had lower CH4 /kg energy corrected milk (ECM) compared to cows in cluster H, 8.3 compared to 9.7 g CH4 /kg ECM, showing that low CH4 cows utilized the feed more efficient for milk production which might indicate a more efficient microbial population or host genetic differences that is reflected in bacterial and archaeal (or methanogens) populations. more...- Published
- 2017
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37. Effective Treatment with Intravitreal Injection of Bevacizumab for Exudative Retinal Detachment Secondary to Choroidal Metastasis of Non-Small Cell Lung Carcinoma.
- Author
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Yasui H, Sato K, Takeyama Y, Nishihara H, Maeda M, Gonda H, and Suzuki R
- Subjects
- Aged, Angiogenesis Inhibitors administration & dosage, Carcinoma, Non-Small-Cell Lung complications, Carcinoma, Non-Small-Cell Lung diagnosis, Choroid Neoplasms diagnosis, Choroid Neoplasms secondary, Fluorescein Angiography, Fundus Oculi, Humans, Intravitreal Injections, Lung Neoplasms complications, Male, Positron-Emission Tomography, Retinal Detachment diagnosis, Retinal Detachment etiology, Tomography, X-Ray Computed, Bevacizumab administration & dosage, Carcinoma, Non-Small-Cell Lung secondary, Choroid Neoplasms complications, Lung Neoplasms pathology, Retinal Detachment drug therapy
- Abstract
Background: Visual disturbance caused by cancer metastasis from other organs is one of the largest challenges to cancer patients' quality of life (QOL). Lung cancer is the most frequent primary site of choroidal metastasis in men, but improvement of visual disturbance has not always been emphasized in lung cancers. Recently intravitreal bevacizumab is a newer modality being tried for local control of choroidal metastases., Case Report: A 68-year-old man was admitted the hospital with complaint of visual disturbance in his left eye. He was diagnosed with lung adenocarcinoma cT2N0M1b (OSS, OTH) stage IV. The ophthalmologic evaluation showed exudative fluid, which caused retinal detachment under the retina. Fluorescence angiography showed granular hyperfluorescence with leakage consistent with a tumor. He received radiotherapy for bone metastasis and systematic chemotherapy with carboplatin, pemetrexed, and bevacizumab, as well as intravitreal injection of bevacizumab 1.25 mg to improve the visual disturbance. His visual symptom and retinal detachment improved until he died. An autopsy revealed that the metastatic lesion in his left eye was totally cured macroscopically and microscopically., Conclusions: We report a case of exudative retinal detachment secondary to a metastatic choroidal tumor from lung adenocarcinoma, which was treated with chemotherapy and intravitreal injection of bevacizumab. Although he finally died of lung cancer, he maintained his visual QOL and autopsy revealed complete cure of the choroidal metastasis. more...
- Published
- 2015
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38. Granulocyte colony-stimulating factor-producing carcinoma of unknown primary site.
- Author
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Yasui H, Sato K, Takeyama Y, Ando A, Kato T, Hashimoto H, Fukui Y, Maeda M, Gonda H, and Suzuki R
- Abstract
Granulocyte colony-stimulating factor (G-CSF)-producing nonhematopoietic malignancies have been reported in various organs and are associated with a poor clinical outcome. Moreover, carcinoma of unknown primary site (CUP) is an uncommon malignancy that occurs in about 2-6% of cancer patients. CUP also has a poor prognosis due to its missing profile. Since both G-CSF-producing carcinoma and CUP are rare, G-CSF-producing CUP (GCSF-CUP) is considered to have an even poorer prognosis and is seldom encountered. Herein, we report the case of a GCSF-CUP patient. A 75-year-old man was admitted to our hospital complaining of cervical lymphadenopathy. Multiple bulky lymph nodes without a primary site were revealed by image analysis. His complete blood count showed leukocytosis, and his blood chemistry panel indicated highly elevated levels of G-CSF. Although the patient was treated with combination chemotherapy of carboplatin, paclitaxel, bevacizumab and erlotinib, he died of intestinal perforation due to tumor invasion 23 days after the start of the therapy. An autopsy confirmed that the tumor was positive for anti-G-CSF antibody, but the primary site was still not detected. more...
- Published
- 2014
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39. Carcinoma of unknown primary site treated with Carboplatin + Paclitaxel + bevacizumab + erlotinib and its maintenance chemotherapy.
- Author
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Yasui H, Sato K, Takeyama Y, Kato T, Hashimoto H, Fukui Y, Yoshihisa N, Maeda M, Gonda H, and Suzuki R
- Abstract
About 3% of all cancer patients suffer from carcinoma of unknown primary site (CUP). In spite of its rarity, we will encounter them. While CUPs manifest a wide variety of clinical presentations, they have often resulted in poor prognosis. Although platinum/taxane combination chemotherapy, e.g. carboplatin (CBDCA) + paclitaxel (PTX) is widely used for patients suffering from CUP, the response rate is only about 30-40% and the median overall survival (OS) is only 9 months, which means that improvement is needed. Among the new regimens, the combination of CBDCA, PTX, bevacizumab (BEV) and erlotinib is thought to be highly promising. Herein, we report a case with CUP treated with this regimen and his maintenance therapy. Our patient was a 75-year-old man who was admitted with a left neck lump. CT revealed systemic massive lymphadenopathy. In spite of various investigations for primary origin, he was diagnosed with CUP and treated with CBDCA + PTX + BEV + erlotinib (AUC 6 + 175 mg/m(2) + 15 mg/kg + 150 mg). Since the evaluation of the efficacy indicated partial response, maintenance chemotherapy (BEV and erlotinib) was performed. Chemotherapy was continued for 9 months until the patient was in a progressive disease state with meningeal dissemination. He died 12 months after the initiation of chemotherapy, which is a longer period than the previously reported OS. Of note, according to our case, CBDCA + PTX + BEV + erlotinib and its maintenance chemotherapy are feasible and well tolerated for CUP. more...
- Published
- 2014
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40. Tracheal adenoid cystic carcinoma treated by repeated bronchoscopic argon plasma coagulation as a palliative therapy.
- Author
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Sato K, Takeyama Y, Kato T, Hashimoto H, Fukui Y, Gonda H, and Suzuki R
- Subjects
- Aged, Biopsy, Carcinoma, Adenoid Cystic pathology, Humans, Male, Time Factors, Tomography, X-Ray Computed, Tracheal Neoplasms pathology, Treatment Outcome, Argon Plasma Coagulation methods, Bronchoscopy methods, Carcinoma, Adenoid Cystic therapy, Palliative Care methods, Tracheal Neoplasms therapy
- Abstract
Primary tracheal tumors are uncommon, making up only 0.2% of all respiratory malignancies. Adenoid cystic carcinoma (ACC) is the most common tumor, accounting for about 30% of primary tracheal tumors. It is often difficult to manage these tumors surgically, due to its expansion and submucosal invasion, and furthermore, due to the patient's condition. Thus, it is essential to perform palliative treatment in order to maintain the airway through and to control the progress. Herein, we report a case of ACC treated by repeated bronchoscopic argon plasma coagulation (APC) as palliative therapy.A 71-year-old Japanese male was referred to our hospital's emergency department for dyspnea. Bronchoscopic examination revealed expanded intraluminal obstructive bronchial tumors from the left bronchus to right. The patient had undergone bronchoscopic APC treatment several times. The obstruction was improved, and no worsening was seen for 26 months. Repeated bronchoscopic APC as a palliative therapy is promising and useful therapy without heavy adverse reactions to control the tumor growth. more...
- Published
- 2014
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- View/download PDF
41. Fulminant hepatic failure and hepatomegaly caused by diffuse liver metastases from small cell lung carcinoma: 2 autopsy cases.
- Author
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Sato K, Takeyama Y, Tanaka T, Fukui Y, Gonda H, and Suzuki R
- Subjects
- Aged, Autopsy, Humans, Male, Middle Aged, Carcinoma, Small Cell pathology, Hepatomegaly etiology, Liver Failure, Acute etiology, Liver Neoplasms complications, Liver Neoplasms secondary, Lung Neoplasms pathology
- Abstract
Fulminant hepatic failure (FHF) is defined as a liver disease that causes encephalopathy within 8 weeks of onset in the absence of pre-existing liver disease. Although liver metastases are commonly found in cancer patients, FHF secondary to diffuse liver infiltration is rare. Here, we report the rare autopsy cases of patients with small cell lung carcinoma (SCLC) and secondary FHF. These patients presented with remarkable hepatomegaly and a near complete replacement of the liver parenchyma with metastatic tumor. Neoplastic involvement of the liver should be considered in the differential diagnosis of FHF., (Copyright © 2013 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.) more...
- Published
- 2013
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42. [A case of multiple metastatic giant rectal GIST successfully treated with surgical intervention after administration of imatinib mesylate].
- Author
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Kitamura D, Ikeda K, Unotoro J, Seki E, Gonda H, and Izumi H
- Subjects
- Aged, Combined Modality Therapy, Gastrointestinal Stromal Tumors pathology, Gastrointestinal Stromal Tumors surgery, Humans, Imatinib Mesylate, Male, Neoplasm Metastasis, Rectal Neoplasms pathology, Rectal Neoplasms surgery, Antineoplastic Agents administration & dosage, Benzamides administration & dosage, Gastrointestinal Stromal Tumors therapy, Piperazines administration & dosage, Pyrimidines administration & dosage, Rectal Neoplasms therapy
- Abstract
A 69-year-old man was admitted with difficulty in defecation and urination. CT showed a giant tumor connected with the rectum in the lower pelvic cavity, and also the presence of 4 smooth surfaced tumors, 3 of which were in the abdominal cavity, while the other one was in the left inguinal region. A core needle biopsy was performed in the left inguinal region indicated the presence of gastrointestinal stromal tumor (GIST), and we clinically diagnosed this case as having multiple metastatic rectal GISTs. The patient was treated with imatinib mesylate, and CT showed the size of the rectal GIST to have dramatically decreased, with only one metastatic tumor remaining in the abdominal cavity. Therefore, an abdominoperineal resection and metastasectomy were performed, and the tumors were completely excised. The patient is alive without recurrence at 18 months after surgery, while continuing to receive imatinib mesylate. more...
- Published
- 2013
43. CBDCA + Pemetrexed + Bevacizumab and Its Maintenance Chemotherapy in a Case of Solitary Breast Metastasis from a Lung Adenocarcinoma Resistant to Gefitinib.
- Author
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Sato K, Takeyama Y, Yoshihara M, Kato T, Hashimoto H, Fukui Y, Gonda H, and Suzuki R
- Abstract
Based on the AVAPERL trial (36th ESMO 2011), CBDCA + pemetrexed + bevacizumab and its maintenance chemotherapy with pemetrexed + bevacizumab is a new promising regimen for the treatment of advanced non-small-cell lung adenocarcinoma. Herein, we report the rare case of a patient with solitary breast metastasis from a lung adenocarcinoma, which was effectively treated using CBDCA + pemetrexed + bevacizumab and its maintenance chemotherapy. A 57-year-old female was admitted to the hospital due to pleural effusion and cardiac tamponade caused by a lung adenocarcinoma possessing a mutation of the epidermal growth factor receptor (EGFR) gene (deletion of exon 19). The patient was treated by first-line chemotherapy (gefitinib 250 mg/body/day) which resulted in complete response. After 12 months, carcinoembryonic antigen was gradually increasing and she complained of a right breast mass. With a core-needle biopsy, the breast tumor was pathologically diagnosed as recurrence and solitary metastasis of a lung adenocarcinoma. Further study of the second mutation of EGFR revealed a T790M mutation. The patient was treated by second-line chemotherapy [CBDCA + pemetrexed + bevacizumab (AUC 6 + 500 mg/m(2) + 15 mg/kg)] and its maintenance chemotherapy (pemetrexed + bevacizumab). The cases of patients with breast metastasis from other organs are very rare. Immunohistopathological analysis is very useful to diagnose whether the malignancy is primary or not. In the case of a breast tumor with present or previous malignancy, a metastatic breast tumor should be considered. Furthermore, the biopsy of the breast metastasis also revealed the second mutation of resistance to gefitinib, T790M. Of note, according to our case, CBDCA + pemetrexed + bevacizumab and its maintenance chemotherapy is feasible and well tolerated for breast metastasis from a lung adenocarcinoma which is resistant to gefitinib and possesses the T790M mutation in the EGFR gene. more...
- Published
- 2012
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44. Expression and function of apoptosis initiator FOXO3 in granulosa cells during follicular atresia in pig ovaries.
- Author
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Matsuda F, Inoue N, Maeda A, Cheng Y, Sai T, Gonda H, Goto Y, Sakamaki K, and Manabe N
- Subjects
- Amino Acid Sequence, Animals, Apoptosis Regulatory Proteins metabolism, Bcl-2-Like Protein 11, Cell Line, Fas Ligand Protein metabolism, Female, Forkhead Box Protein O3, Forkhead Transcription Factors chemistry, Forkhead Transcription Factors genetics, Forkhead Transcription Factors metabolism, Granulosa Cells cytology, Humans, Membrane Proteins metabolism, Molecular Sequence Data, Organ Specificity, Ovarian Follicle cytology, Ovarian Follicle metabolism, Protein Isoforms genetics, Protein Isoforms metabolism, Proto-Oncogene Proteins metabolism, RNA, Messenger chemistry, RNA, Messenger metabolism, Sequence Alignment, Sequence Homology, Amino Acid, Sexual Maturation, Sus scrofa, Apoptosis, Follicular Atresia metabolism, Forkhead Transcription Factors physiology, Gene Expression Regulation, Granulosa Cells metabolism
- Abstract
In mammalian ovaries, most follicles are lost by atresia before ovulation. It has become apparent that the apoptosis of granulosa cells induces follicular atresia. Forkhead box O3 (FOXO3), also called FKHRL1 (forkhead in rhabdomyosarcoma-like 1), is a proapoptotic molecule that belongs to the FOXO subfamily of forkhead transcription factors. Foxo3-deficient female mice were reported to be infertile because of abnormal ovarian follicular development, but the precise influences of FOXO3 on follicular atresia of mature ovary have not been determined. Therefore, we examined the expression and function of FOXO3 in porcine ovarian follicles and granulosa-derived cells. FOXO3 mRNA levels in granulosa cells of porcine ovaries increased during atresia, while FOXO3 protein was abundant in granulosa cells of early atretic follicles. By immunohistochemistry, the inner surface area of the granulosa layer in early atretic follicles was strongly stained with anti-FOXO3 antibody. The granulosa cells expressing FOXO3 coincided with apoptotic cells, indicating a role of FOXO3 as a proapoptotic factor in granulosa cells of porcine ovaries. In porcine (JC-410) and human (KGN) granulosa-derived cells, cell death was induced by transfection of FOXO3 expression vectors. Expression of the proapoptotic factors Fas ligand (FASLG) and BCL2-like 11 (BCL2L11) was upregulated by FOXO3 in KGN cells. In conclusion, FOXO3 is expressed in porcine ovarian follicles and induces apoptosis in granulosa cells, suggesting that it is a candidate for the initiator of follicular atresia. more...
- Published
- 2011
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45. Reversal of diastereoselectivity in reactions of the trifluoroacetaldehyde ethyl hemiacetal with enamines and imines: metal-free, complementary anti- and syn-selective synthesis of 4,4,4-trifluoro-1-aryl-3-hydroxy-2-methyl-1-butanones.
- Author
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Funabiki K, Matsunaga K, Gonda H, Yamamoto H, Arima T, Kubota Y, and Matsui M
- Subjects
- Acetaldehyde chemistry, Catalysis, Magnetic Resonance Spectroscopy, Molecular Structure, Stereoisomerism, Acetaldehyde analogs & derivatives, Amines chemistry, Butanones chemistry, Imines chemistry
- Abstract
A complete reversal of diastereoselectivity was observed for reactions of the trifluoroacetaldehyde ethyl hemiacetal with enamines and imines, derived from propiophenones, that produce 4,4,4-trifluoro-1-aryl-3-hydroxy-2-methyl-1-butanones. This process serves as the first reliable, metal-free, complementary anti- and syn-selective method to prepare 4,4,4-trifluoro-1-aryl-3-hydroxy-2-methyl-1-butanones. more...
- Published
- 2011
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- View/download PDF
46. [In vitro susceptibilities to levofloxacin and various antibacterial agents of 12,919 clinical isolates obtained from 72 centers in 2007].
- Author
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Yamaguchi K, Ohno A, Ishii Y, Tateda K, Iwata M, Kanda M, Akizawa K, Shimizu C, Kon S, Nakamura K, Matsuda K, Tominaga M, Nakagawa T, Sugita A, Ito T, Kato J, Suwabe A, Yamahata K, Kawamura C, Tashiro H, Horiuchi H, Katayama Y, Kondou S, Misawa S, Murata M, Kobayashi Y, Okamoto H, Yamazaki K, Okada M, Haruki K, Kanno H, Aihara M, Maesaki S, Hashikita G, Miyajima E, Sumitomo M, Saito T, Yamane N, Kawashima C, Akiyama T, Ieiri T, Yamamoto Y, Okamoto Y, Okabe H, Moro K, Shigeta M, Yoshida H, Yamashita M, Hida Y, Takubo T, Kusakabe T, Masaki H, Heijyou H, Nakaya H, Kawahara K, Sano R, Matsuo S, Kono H, Yuzuki Y, Ikeda N, Idomuki M, Soma M, Yamamoto G, Kinoshita S, Kawano S, Oka M, Kusano N, Kang D, Ono J, Yasujima M, Miki M, Hayashi M, Okubo S, Toyoshima S, Kaku M, Sekine I, Shiotani J, Horiuchi H, Tazawa Y, Yoneyama A, Kumasaka K, Koike K, Taniguchi N, Ozaki Y, Uchida T, Murakami M, Inuzuka K, Gonda H, Yamaguchi I, fujimoto Y, Iriyama J, Asano Y, Genma H, Maekawa M, Yoshimura H, Nakatani K, Baba H, Ichiyama S, Fujita S, Kuwabara M, Okazaki T, Fujiwara H, Ota H, Nagai A, Fujita J, Negayama K, Sugiura T, Kamioka M, Murase M, Yamane N, Nakasone I, Okayama A, Aoki Y, Kusaba K, Nakashima Y, Miyanohara H, Hiramatsu K, Saikawa T, Yanagihara K, Matsuda J, Kohno S, and Mashiba K more...
- Subjects
- Drug Resistance, Bacterial, Drug Resistance, Multiple, Bacterial, Gastrointestinal Diseases microbiology, Humans, Japan, Respiratory Tract Infections microbiology, Time Factors, Urinary Tract Infections microbiology, Anti-Bacterial Agents pharmacology, Bacteria drug effects, Bacteria isolation & purification, Levofloxacin, Ofloxacin pharmacology
- Abstract
We have reported in this journal in vitro susceptibilities of clinical isolates to antibiotics every year since 1992. In this paper, we report the results of an analysis of in vitro susceptibilities of 12,919 clinical isolates from 72 centers in Japan to selected antibiotics in 2007 compared with the results from previous years. The common respiratory pathogens, Streptococcus pyogenes, Streptococcus pneumoniae, Moraxella catarrhalis and Haemophilus influenzae maintained a high susceptibility to fluoroquinolones (FQs). The resistance of S. pyogenes to macrolides has been increasing every year and this was especially clear this year. Most strains of Enterobacteriaceae except for Escherichia coli showed a high susceptibility to FQs. Almost 30% of E. coli strains were resistant to FQs and the resistance increased further this year. FQs resistance of methicillin-resistant Staphylococcus aureus (MRSA) was approximately 95% with the exception of 45% for sitafloxacin (STFX). FQs resistance of methicillin-susceptible S. aureus (MSSA) was low at about 10%. FQs resistance of methicillin-resistant coagulase negative Staphylococci (MRCNS) was higher than that of methicillin-susceptible coagulase negative Staphylococci (MSCNS), but it was lower than that of MRSA. However, FQs resistance of MSCNS was higher than that of MSSA. FQs resistance of Enterococcus faecalis was 22.5% to 29.6%, while that of Enterococcusfaecium was more than 85% except for STFX (58.3%). In clinical isolates of Pseudomonas aeruginosa derived from urinary tract infections, FQs resistance was 21-27%, which was higher than that of P. aeruginosa from respiratory tract infections at 13-21%, which was the same trend as in past years. Multidrug resistant strains accounted for 5.6% in the urinary tract and 1.8% in the respiratory tract. Acinetobacter spp. showed high susceptibility to FQs. The carbapenem resistant strains, which present a problem at present, accounted for 2.7%. Neisseria gonorrhoeae showed high resistance of 86-88% to FQs. The results of the present survey indicated that although methicillin-resistant Staphylococci, Enterococci, E. coli, P. aeruginosa, and N. gonorrhoeae showed resistance tendencies, and other species maintained high susceptibility rates more than 90% against FQs, which have been used clinically for over 15 years. more...
- Published
- 2009
47. A phase II study of carboplatin and paclitacel with meloxicam.
- Author
-
Suzuki R, Yamamoto M, Saka H, Taniguchi H, Shindoh J, Tanikawa Y, Nomura F, Gonda H, Imaizumi K, Hasegawa Y, and Shimokata K
- Subjects
- Adult, Aged, Female, Humans, Male, Meloxicam, Middle Aged, Quality of Life, Time Factors, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carboplatin administration & dosage, Carcinoma, Non-Small-Cell Lung drug therapy, Lung Neoplasms drug therapy, Paclitaxel administration & dosage, Thiazines administration & dosage, Thiazoles administration & dosage
- Abstract
Background: Cyclooxygenase (COX-2) overexpression is seen in many malignancies including lung cancer. Recent pre-clinical studies have shown that selective COX-2 inhibitors have demonstrated promising results when used with chemotherapy. Based on these observations, we assessed the efficacy and tolerability of the combination chemotherapy consisting of carboplatin and paclitaxel with meloxicam, a selective COX-2 inhibitor., Methods: Forty-four patients with stage IIIB or IV non-small cell lung cancer (NSCLC), Eastern Cooperative Oncology Group performance status (PS) 0 or 1, who had adequate organ function, were eligible. Patients received paclitaxel 70 mg/m(2) weekly for 3 of 4 weeks with carbopltin (AUC 6) on day 1, as well as daily meloxicam (10 mg/day). The response rate was the primary endpoint. Secondary endpoints were overall survival, toxicity profile and quality of life (using European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and LC13)., Results: From March 2005 to September 2006, 44 patients were evaluated in this study. Gender M/F, 31/13; median age, 64 years (range, 34-75); stage IIIB/IV, 11/33; PS0/1, 22/22; histology Ad/Sq/Other, 29/6/9. Partial response was observed in 19 patients (43%) with stable disease, and there was no complete response, for an overall response rate of 43% (95% confidence interval, 28.5-57.8%). Ten patients (23%) had grade (G) 3 and three (7%) had G4 neutropenia. Three patients (7%) had G3 thrombocytopenia. As for non-hematological toxicities, one case of G4 toxicity (perforation of jejunum) was observed, but other toxicities were mild (one muscle pain, two liver dysfunction, one fatigue and one nausea G3). Grade 2 peripheral neuropathy was observed in only one patient. Using the EORTC QLQ questionnaire, the global health status did not change significantly during this therapy (before and 4 and 8 weeks later). Median follow-up was 13.6 months (range, 1.8-31.3 months). By the time of the final analysis (October 2007), 26 of the initial 44 patients had died. The 1-year survival rate was 64% and median survival time was 15.9 months., Conclusions: Meloxicam in combination with carboplatin and weekly paclitaxel chemotherapy showed promising activity with encouraging survival. This therapy is relatively well tolerated in advanced NSCLC. more...
- Published
- 2009
- Full Text
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48. Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs.
- Author
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Katakai T, Suto H, Sugai M, Gonda H, Togawa A, Suematsu S, Ebisuno Y, Katagiri K, Kinashi T, and Shimizu A
- Subjects
- Aging immunology, Animals, Animals, Newborn, B-Lymphocytes cytology, B-Lymphocytes immunology, Cell Line, Cell Line, Tumor, Cell Movement genetics, Chemokine CXCL13 biosynthesis, Fibroblasts immunology, Fibroblasts metabolism, Humans, Lymphoid Tissue embryology, Lymphoid Tissue metabolism, Lymphotoxin beta Receptor physiology, Mesoderm metabolism, Mice, Mice, Inbred BALB C, Mice, Mutant Strains, Protein Serine-Threonine Kinases physiology, Signal Transduction immunology, Stromal Cells cytology, Stromal Cells immunology, Stromal Cells metabolism, NF-kappaB-Inducing Kinase, Lymphoid Tissue cytology, Lymphoid Tissue immunology, Mesoderm cytology, Mesoderm immunology
- Abstract
Mesenchymal stromal cells are crucial components of secondary lymphoid organs (SLOs). Organogenesis of SLOs involves specialized stromal cells, designated lymphoid tissue organizer (LTo) in the embryonic anlagen; in the adult, several distinct stromal lineages construct elaborate tissue architecture and regulate lymphocyte compartmentalization. The relationship between the LTo and adult stromal cells, however, remains unclear, as does the precise number of stromal cell types that constitute mature SLOs are unclear. From mouse lymph nodes, we established a VCAM-1(+)ICAM-1(+)MAdCAM-1(+) reticular cell line that can produce CXCL13 upon LTbetaR stimulation and support primary B cell adhesion and migration in vitro. A similar stromal population sharing many characteristics with the LTo, designated marginal reticular cells (MRCs), was found in the outer follicular region immediately underneath the subcapsular sinus of lymph nodes. Moreover, MRCs were commonly observed at particular sites in various SLOs even in Rag2(-/-) mice, but were not found in ectopic lymphoid tissues, suggesting that MRCs are a developmentally determined element. These findings lead to a comprehensive view of the stromal composition and architecture of SLOs. more...
- Published
- 2008
- Full Text
- View/download PDF
49. Molecular cloning of a porcine (Sus scrofa) apoptosis inhibitory ligand, netrin-1, and its receptor, p53RDL1.
- Author
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Maeda A, Matsuda F, Goto Y, Cheng Y, Gonda H, Inoue N, Nakagawa S, and Manabe N
- Subjects
- Amino Acid Sequence, Animals, Apoptosis genetics, Apoptosis Regulatory Proteins genetics, Apoptosis Regulatory Proteins metabolism, Cloning, Molecular, DNA, Complementary isolation & purification, Female, Follicular Atresia genetics, Follicular Atresia metabolism, Gene Expression Regulation, Granulosa Cells metabolism, Molecular Sequence Data, Nerve Growth Factors metabolism, Netrin Receptors, Netrin-1, RNA, Messenger metabolism, Receptors, Cell Surface metabolism, Sequence Homology, Amino Acid, Sus scrofa metabolism, Tissue Distribution, Tumor Suppressor Proteins metabolism, Nerve Growth Factors genetics, Receptors, Cell Surface genetics, Sus scrofa genetics, Tumor Suppressor Proteins genetics
- Abstract
The apoptosis inhibitory ligand (Netrin-1) and its receptor (p53-regulated receptor for death and life: p53RDL1) play an important role in the regulation of selective apoptosis. When Netrin-1 binds to p53RDL1, p53-dependent apoptosis is inhibited. We identified porcine (Sus scrofa) cDNAs encoding Netrin-1 [pNetrin-1; 1,803 base pairs (bp) and 600 amino acids (aa)] and p53RDL1 (pp53RDL1; 2,838 bp and 945 aa). Porcine p53RDL1 (pp53RDL1) contains a death domain (DD), a tandem specific amino acid region, in its C-terminal, suggesting that it mediates death signaling by binding with other pro-apoptotic factors via the DD. Porcine Netrin-1 (pNetrin-1), pp53RDL1 and the DD in pp53RDL1 showed high levels of identity in aa sequence with human and murine Netrin-1 (98 and 97%, respectively), p53RDL1 (94 and 91%, respectively) and the DD in p53RDL1 (96 and 95%, respectively). Reverse transcription-polymerase chain reaction (RT-PCR) revealed that the levels of pNetrin-1 and pp53RDL1 mRNAs were moderate in granulosa cells compared with their expression in other tissues and that their levels during follicular atresia were stable. The Netrin-1 and p53RDL1 system may regulate the induction of apoptosis in porcine granulosa cells. more...
- Published
- 2008
- Full Text
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50. [A surgically treated case of ileus caused by small intestinal tuberculosis during treatment for pulmonary tuberculosis].
- Author
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Ida N, Yamamoto K, Gonda H, Oishi T, Suganuma N, Yamaguchi I, Kinoshita K, and Suzuki R
- Subjects
- Adult, Antitubercular Agents administration & dosage, Ethambutol administration & dosage, Humans, Isoniazid administration & dosage, Male, Pyrazinamide administration & dosage, Rifampin administration & dosage, Ileal Diseases complications, Ileus surgery, Tuberculosis, Gastrointestinal complications, Tuberculosis, Pulmonary drug therapy
- Abstract
A 44-year-old man consulted medical clinic, complaining of cough and sputum. Then he was admitted to our hospital, because of positive acid-fast bacilli in his sputum and positive PCR (polymerase chain reaction) for Mycobacterium tuberculosis. Combined use of isoniazid (INH), rifampicin (RFP), ethambutol (EB) and pyrazinamide (PZA) was started. But 4 days after starting treatment, we had to suspend tuberculosis chemotherapy because of hepatopathy. Since then he started to complain epigastralgia and vomiting. Plain abdominal X-ray and abdominal computed tomography (CT) led to a diagnosis of ileus. Inspite of insertion of ileus tube symptoms of ileus did not improve. Small bowl series showed severe stenosis at ileum end, necessitating jejunectomy. Macroscopic study revealed a ring ulcer and multiple epithelioid cell granuloma with Langhans' giant cells was detected histopathologically. PCR for M. tuberculosis of extracts from ileum was positive. Therefore the patient was diagnosed small intestinal tuberculosis. Treatment was continued by the combination of INH, RFP, EB, and the symptoms markedly improved. There have been no sign of recurrence since the end of the 6-month treatment for tuberculosis. more...
- Published
- 2007
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