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1. CORRELATION BETWEEN CHRONIC SYSTEMIC INFLAMMATION, LIPID SPECTRUM, LIVER FUNCTION AND ANTIOXIDANT SYSTEM IN PATIENTS WITH COMORBID PATHOLOGY OF STABLE CORONARY HEART DISEASE WITH NONALCOHOLIC FATTY LIVER DISEASE

Author

Manusha Yu. I., Goncharova O. O., Sakevich V. D., Chekalina N. I., and Kazakov Yu. M.

Subjects
ischemic heart disease, nonalcoholic fatty liver disease, chronic systemic inflammation, dislipidemia, endothelial dysfunction, correlation., Medicine, Biology (General), QH301-705.5
Abstract

The aim of the study was to examine the correlations between markers of chronic systemic inflammation (CHD), inflammatory endothelial activation, blood lipid spectrum, antioxidant system, liver and heart function in patients with stable coronary heart disease in combination with non-alcoholic fatty liver disease. The study involved 110 people with coronary heart disease: stable angina pectoris, II FC, CH 0-I in combination with non-alcoholic fatty liver disease aged 40-69 years. The analysis of indicators of a lipid spectrum of blood is made, studied the level of ceruloplasmin, cytokines (IL-6, TNFα, IL-10), circulating endothelial microparticles (CEM) CD32+ CD40+ in the blood, the expression of kappa B inhibitor mRNA gene α (IkBα) of nuclear kappa B transcription factor in peripheral blood mononuclear cells was studied and echocardiography, liver ultrasound with color and pulse Doppler imaging were performed (blood flow velocity in portal and hepatic veins was established). The relationship between the variables was then studied by correlation analysis. Conclusion. The correlation analysis established the relationship between the expression of mRNA IkBα nuclear transcription factor Kappa B with chronic systemic inflammation of low intensity, lipid metabolism with dysfunctional changes in blood flow in the liver (blood flow velocity in the portal vein), we can conclude that chronic systemic inflammation at the molecular genetic level plays an important role in the development of both coronary heart disease and nonalcoholic fatty liver disease and confirms the common pathogenetic mechanism of this comorbid pathology.

Published
2020
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2. A Pilot National Network for Monitoring Soil Respiration in Russia: First Results and Prospects of Development

Author

Kurganova, I. N., Karelin, D. V., Kotlyakov, V. M., Prokushkin, A. S., Zamolodchikov, D. G., Ivanov, A. V., Ilyasov, D. V., Khoroshaev, D. A., de Gerenyu, V. O. Lopes, Bobrik, A. A., Bryanin, S. V., Goncharova, O. Yu., Ershov, V. V., Ivanov, D. G., Zorina, S. Yu., Kaganov, V. V., Kapitsa, E. A., Koptsik, G. N., Kuznetsov, M. A., Kumanyaev, A. S., Kuprin, A. V., Mamai, A. V., Matvienko, A. I., Makhnykina, A. V., Mostovaya, A. S., Moshkina, E. V., Mothenov, S. Yu., Ryabov, N. S., Sapronov, D. V., Sidenko, N. V., Sokolova, L. G., Sorokin, A. S., Suvorov, G. G., Sukhoveeva, O. E., Chumbaev, A. S., and Shmakova, N. Yu.

Published
2024
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48. Creativity as a new driver of tourist attractiveness of cities

Author

Stakhova, L. V., Nikolskaya, E. Yu., Khristov, T. T., and Goncharova, O. N.

Subjects
creative tourist environment, urban tourism, criteria for the effectiveness of the tourist environment of a creative city, creative tourism, creative city
Abstract

Today many cities experience changing in their role in the modern economy and functional structure. At the same time tourists search an unusual tourist experience, and all this brings to the fore the issues of the urban environment creativity. They are of relevance in cities suffered from crisis phenomena - the decline of city-forming enterprises, a high level of unemployment, etc. In this case, attracting creative capital becomes a development tool, and creativity is seen as a new point of growth. At the same time, creative objects, spaces and cities are perceived by tourists ambiguously. The cities following the transformation path into creative urban centers not always demonstrate successful results. This is largely due to the vagueness of the concept of a creative city, misunderstanding of the criteria for the effectiveness of a creative environment, and sometimes incorrect assessment of the target audience of a creative city as a tourist center. The article analyzes the concept of "creative city", reveals its key properties. An analysis of the tourist products presented on the market, made it possible to identify the formats for organizing creative urban tourism. Audience of its tourists and visitors is another indicator of the tourist city creativity. Based on a survey, the article characterizes the target audience of a creative city as a tourist center., Originally published in https://stcc.rgutspubl.org/index.php/1/article/view/84

Published
2023
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