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30 results on '"Goncalves, Bronner"'

1. Using Bottleneck Adapters to Identify Cancer in Clinical Notes under Low-Resource Constraints

Author

Rohanian, Omid, Jauncey, Hannah, Nouriborji, Mohammadmahdi, Chauhan, Vinod Kumar, Gonçalves, Bronner P., Kartsonaki, Christiana, Group, ISARIC Clinical Characterisation, Merson, Laura, and Clifton, David

Subjects
Computer Science - Computation and Language, Computer Science - Artificial Intelligence, 68T50, I.2.7
Abstract

Processing information locked within clinical health records is a challenging task that remains an active area of research in biomedical NLP. In this work, we evaluate a broad set of machine learning techniques ranging from simple RNNs to specialised transformers such as BioBERT on a dataset containing clinical notes along with a set of annotations indicating whether a sample is cancer-related or not. Furthermore, we specifically employ efficient fine-tuning methods from NLP, namely, bottleneck adapters and prompt tuning, to adapt the models to our specialised task. Our evaluations suggest that fine-tuning a frozen BERT model pre-trained on natural language and with bottleneck adapters outperforms all other strategies, including full fine-tuning of the specialised BioBERT model. Based on our findings, we suggest that using bottleneck adapters in low-resource situations with limited access to labelled data or processing capacity could be a viable strategy in biomedical text mining. The code used in the experiments are going to be made available at https://github.com/omidrohanian/bottleneck-adapters.

Published
2022

2. Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms

Author

Moharam, S.A., Abdalasalam, Sabriya, Abdalhadi, Alaa Abdalfattah, Abdalla, Naana Reyam, Abdalla, Walaa, Abdalrheem, Almthani Hamza, Abdalsalam, Ashraf, Abdeewi, Saedah, Abdelgaum, Esraa Hassan, Abdelhalim, Mohamed, Abdelkabir, Mohammed, Abdelrahman, Israa, Abdukahil, Sheryl Ann, Abdulbaqi, Lamees Adil, Abdulhamid, Salaheddin, Abdulhamid, Widyan, Abdulkadir, Nurul Najmee, Abdulwahed, Eman, Abdunabi, Rawad, Abe, Ryuzo, Abel, Laurent, Abodina, Ahmed Mohammed, Abrous, Amal, Absil, Lara, Jabal, Kamal Abu, Salah, Nashat Abu, Abusalama, Abdurraouf, Abuzaid, Tareg Abdallah, Acharya, Subhash, Acker, Andrew, Adam, Elisabeth, Adem, Safia, Ademnou, Manuella, Adewhajah, Francisca, Adrião, Diana, Afum-Adjei Awuah, Anthony, Agbogbatey, Melvin, Al Ageel, Saleh, Ahmed, Aya Mustafa, Ahmed, Musaab Mohammed, Ahmed, Shakeel, Alaraji, Zainab Ahmed, Elhefnawy Enan, Abdulrahman Ahmed, Ahmed Khalil, Reham Abdelhamid, Ahmed Mohamed Abdelaziz, Ali Mostafa, Ainscough, Kate, Airlangga, Eka, Aisa, Tharwat, Aisha, Ali, Aisha, Bugila, Hssain, Ali Ait, Tamlihat, Younes Ait, Akimoto, Takako, Akmal, Ernita, Akwani, Chika, Al Qasim, Eman, Alajeeli, Ahmed, Alali, Ahmed, Alalqam, Razi, Alameen, Aliya Mohammed, Al-Aquily, Mohammed, Alaraji, Zinah A., Albakry, Khalid, Albatni, Safa, Alberti, Angela, Aldabbourosama, Osama, Al-dabbous, Tala, Aldhalia, Amer, Aldoukali, Abdulkarim, Alegesan, Senthilkumar, Alessi, Marta, Alex, Beatrice, Alexandre, Kévin, Al-Fares, Abdulrahman, Alflite, Asil, Alfoudri, Huda, Alhadad, Qamrah, Alhaddad, Hoda Salem, Mohamed Abdalla Alhasan, Maali Khalid, Alhouri, Ahmad Nabil, Alhouri, Hasan, Ali, Adam, Ali, Imran, TagElser Mohammed Ali, Maha, Abbas, Syed Ali, Abdelghafar, Yomna Ali, Sheikh, Naseem Ali, Alidjnou, Kazali Enagnon, Aljadi, Mahmoud, Aljamal, Sarah, Alkahlout, Mohammed, Alkaseek, Akram, Alkhafajee, Qabas, Allavena, Clotilde, Allou, Nathalie, Almasri, Lana, Almjersah, Abdulrahman, Alqandouz, Raja Ahmed, Alrfaea, Walaa, Alrifaee, Moayad, Alsaadi, Rawan, Al-Saba'a, Yousef, Alshareea, Entisar, Alshenawy, Eslam, Altaf, Aneela, Alves, João Melo, Alves, João, Alves, Rita, Cabrita, Joana Alves, Amaral, Maria, Amer, Amro Essam, Amira, Nur, Adusei, Amos Amoako, Amuasi, John, Andini, Roberto, Andrejak, Claire, Angheben, Andrea, Angoulvant, François, Ankrah, Sophia, Ansart, Séverine, Anthonidass, Sivanesen, Antonelli, Massimo, Antunes de Brito, Carlos Alexandre, Apriyana, Ardiyan, Arabi, Yaseen, Aragao, Irene, Arancibia, Francisco, Araujo, Carolline, Arcadipane, Antonio, Archambault, Patrick, Arenz, Lukas, Arlet, Jean-Benoît, Arnold-Day, Christel, Arora, Lovkesh, Arora, Rakesh, Artaud-Macari, Elise, Aryal, Diptesh, Asensio, Angel, Ashley, Elizabeth A., Ashraf, Muhammad, Ashraf, Muhammad Sheharyar, Ben Ashur, Abir, Asiedu-Bekoe, Franklin, Asif, Namra, Asim, Mohammad, Assi, Grace, Assie, Jean Baptiste, Asyraf, Amirul, Atangana, Fouda, Atia, Ahmed, Atif, Minahel, Abdelrhman Abdallahrs, Asia Atif, Atique, Anika, Atlowly, Moad, Attanyake, AM Udara Lakshan, Auchabie, Johann, Aumaitre, Hugues, Auvet, Adrien, Ali Mohammed, Abdelmalek Awad, Axelsen, Eyvind W., Ayad, Ared, Hassan Helmi, Ahmed Ayman, Azemar, Laurène, Azizeldin, Mohammed, Azoulay, Cecile, Babatunde, Hakeem, Bach, Benjamin, Bachelet, Delphine, Badr, Claudine, Bævre-Jensen, Roar, Baig, Nadia, Baillie, John Kenneth, Baird, J Kevin, Bak, Erica, Bakakos, Agamemnon, Bakar, Nazreen Abu, Bakeer, Hibah Bileid, Bakri, Ashraf, Bal, Andriy, Balakrishnan, Mohanaprasanth, Bandoh, Irene, Bani-Sadr, Firouzé, Barbalho, Renata, Barbosa, Nicholas Yuri, Barclay, Wendy S., Barnett, Saef Umar, Barnikel, Michaela, Barrasa, Helena, Barrigoto, Cleide, Bartoli, Marie, Baruch, Joaquín, Basmaci, Romain, Basri, Muhammad Fadhli Hassin, Batool, AbdAlkarim, Battaglini, Denise, Bauer, Jules, Bautista Rincon, Diego Fernando, Dow, Denisse Bazan, Beane, Abigail, Bedossa, Alexandra, Bee, Ker Hong, Begum, Husna, Behilill, Sylvie, Beishuizen, Albertus, Beljantsev, Aleksandr, Bellemare, David, Beltrame, Anna, Beltrão, Beatriz Amorim, Beluze, Marine, Benech, Nicolas, Benjiman, Lionel Eric, Bennett, Suzanne, Bento, Luís, Berdal, Jan-Erik, Berdeweel, Lamis, Bergeaud, Delphine, Bergin, Hazel, Bertoli, Giulia, Bertolino, Lorenzo, Bessis, Simon, Bevilcaqua, Sybille, Bezulier, Karine, Bhatt, Amar, Bhavsar, Krishna, Bianchi, Isabella, Bianco, Claudia, Bichoka, Sandra, Bidin, Farah Nadiah, Humaid, Felwa Bin, Bin Kamarudin, Mohd Nazlin, Binnawara, Muhannud, Bisoffi, Zeno, Biston, Patrick, Bitker, Laurent, Bittaye, Mustapha, Bitton, Jonathan, Blanco-Schweizer, Pablo, Blier, Catherine, Bloos, Frank, Blot, Mathieu, Boccia, Filomena, Bodenes, Laetitia, Bogaert, Debby, Boivin, Anne-Hélène, Bolanga, Ariel, Bolaños, Isabela, Bolze, Pierre-Adrien, Bompart, François, Bonifasius, Aurelius, Bonney, Joe, Borges, Diogo, Borie, Raphaël, Bosse, Hans Martin, Botelho-Nevers, Elisabeth, Bouadma, Lila, Bouchaud, Olivier, Bouchez, Sabelline, Bouhour, Damien, Bouiller, Kévin, Bouillet, Laurence, Bouisse, Camile, Bountthasavong, Latsaniphone, Boureau, Anne-Sophie, Bourke, John, Bouscambert, Maude, Bousquet, Aurore, Boyer-Besseyre, Marielle, Boylan, Maria, Bozza, Fernando Augusto, Braconnier, Axelle, Braga, Cynthia, Brandenburger, Timo, Monteiro, Filipa Brás, Brazzi, Luca, Breen, Dorothy, Breen, Patrick, Brewster, David, Brickell, Kathy, Broadley, Tessa, Brotherton, Helen, Browne, Alex, Brozzi, Nicolas, Brunvoll, Sonja Hjellegjerde, Brusse-Keizer, Marjolein, Bryda, Petra, Buchtele, Nina, Bugaeva, Polina, Buisson, Marielle, Buonsenso, Danilo, Burhan, Erlina, Buri, Donald, Burrell, Aidan, Bustos, Ingrid G., Butnaru, Denis, Cabie, André, Cabral, Susana, Cabrita, Joana, Caceres, Eder, Cadoz, Cyril, Garcês, Rui Caetano, Calligy, Kate, Calvache, Jose Andres, Camões, João, Campana, Valentine, Campbell, Paul, Campisi, Josie, Canepa, Cecilia, Cantero, Mireia, Caoili, Janice, Caraux-Paz, Pauline, Cárcel, Sheila, Cardoso, Filipa, Cardoso, Filipe, Cardoso, Nelson, Cardoso, Sofia, Carelli, Simone, Carlier, Nicolas, Carmoi, Thierry, Carney, Gayle, Carqueja, Inês, Carret, Marie-Christine, Carrier, François Martin, Carroll, Ida, Carson, Gail, Casanova, Maire-Laure, Cascão, Mariana, Casey, Siobhan, Casimiro, José, Cassandra, Bailey, Castañeda, Silvia, Castanheira, Nidyanara, Castor-Alexandre, Guylaine, Castro, Ivo, Catarino, Ana, Catherine, François-Xavier, Cattaneo, Paolo, Cavalin, Roberta, Cavalli, Giulio Giovanni, Cavayas, Alexandros, Ceccato, Adrian, Ceesay, Masaneh, Cerkovnik, Shelby, Cervantes-Gonzalez, Minerva, Cevik, Muge, Chair, Anissa, Chakveatze, Catherine, Chan, Adrienne, Chand, Meera, Chapplain, Jean-Marc, Charpentier, Charlotte, Chas, Julie, Chaudry, Muhammad Mobin, Chávez Iñiguez, Jonathan Samuel, Chen, Anjellica, Chen, Yih-Sharng, Chenard, Léo, Cheng, Matthew Pellan, Cheret, Antoine, Chiarabini, Thibault, Chica, Julian, Chidambaram, Suresh Kumar, Tho, Leong Chin, Chirouze, Catherine, Chiumello, Davide, Cho, Sung-Min, Cholley, Bernard, Chommanam, Danoy, Chopin, Marie-Charlotte, Chow, Yock Ping, Chow, Ting Soo, Christy, Nathaniel, Chua, Hiu Jian, Chua, Jonathan, Cidade, Jose Pedro, Cisneros Herreros, José Miguel, Citarella, Barbara Wanjiru, Ciullo, Anna, Clarke, Jennifer, Claure-Del Granado, Rolando, Clohisey, Sara, Codan, Cassidy, Cody, Caitriona, Coles, Jennifer, Coles, Megan, Colin, Gwenhaël, Collins, Michael, Combs, Pamela, Connolly, Jennifer, Connor, Marie, Conrad, Anne, Conway, Elaine, Cooke, Graham S., Cordel, Hugues, Corley, Amanda, Cornelis, Sabine, Cornet, Alexander Daniel, Corpuz, Arianne Joy, Cortegiani, Andrea, Corvaisier, Grégory, Couffignal, Camille, Couffin-Cadiergues, Sandrine, Courtois, Roxane, Cousse, Stéphanie, Cowan, Juthaporn, Cregan, Rachel, Crowl, Gloria, Crump, Jonathan, Cruz, Claudina, Csete, Marc, Cullen, Ailbhe, Cummings, Matthew, Curley, Gerard, Curlier, Elodie, Curran, Colleen, Custodio, Paula, da Silva Filipe, Ana, Da Silveira, Charlene, Dabaliz, Al-Awwab, Dagens, Andrew, Dahl, John Arne, Dahly, Darren, D'Alessandro, Umberto, Daley, Peter, Dalloul, Zaina, Dalton, Heidi, Dalton, Jo, Daly, Seamus, Damas, Juliana, Dame, Joycelyn, Damien, Cammandji, Daneman, Nick, Dantas, Jorge, D'Aragon, Frédérick, de Loughry, Gillian, de Mendoza, Diego, De Montmollin, Etienne, França, Rafael Freitas de Oliveira, Isabel de Pinho Oliveira, Ana, De Rosa, Rosanna, De Rose, Cristina, de Silva, Thushan, de Vries, Peter, Deacon, Jillian, Dean, David, Debard, Alexa, DeBenedictis, Bianca, Debray, Marie-Pierre, DeCastro, Nathalie, Dechert, William, Decours, Romain, Defous, Eve, Delacroix, Isabelle, Delamou, Alexandre, Delaveuve, Eric, Delavigne, Karen, Delfos, Nathalie M., Deligiannis, Ionna, Dell'Amore, Andrea, Delmas, Christelle, Delobel, Pierre, Delsing, Corine, Demonchy, Elisa, Denis, Emmanuelle, Deplanque, Dominique, Depuydt, Pieter, Descamps, Diane, Desvallées, Mathilde, Dewayanti, Santi, Dhangar, Pathik, Diallo, Alpha, Diallo, Souleymane Taran, Diamantis, Sylvain, Dias, André, Da Silva, Fernanda Dias, Diaz, Rodrigo, Diaz, Juan Jose, Diaz, Priscila, Dibba, Bakary K., Didier, Kévin, Diehl, Jean-Luc, Dieperink, Wim, Dimet, Jérôme, Dinot, Vincent, Diop, Fara, Diouf, Alphonsine, Dishon, Yael, Djadda, Cedric, Djossou, Félix, Docherty, Annemarie B., Doherty, Helen, Dondorp, Arjen M., Donnelly, Christl A., Donohue, Yoann, Donohue, Sean, Doran, Peter, Dorival, Céline, D'Ortenzio, Eric, Doshi, Yash, Douangdala, Phouvieng, Douglas, James Joshua, Douma, Renee, Dournon, Nathalie, Downey, Joanne, Downing, Mark, Drake, Thomas, Driscoll, Aoife, Duah, Ibrahim Kwaku, Fonseca, Claudio Duarte, Dubee, Vincent, Dubos, François, Dubot-Pérès, Audrey, Ducancelle, Alexandre, Duculan, Toni, Dudman, Susanne, Duggal, Abhijit, Dunand, Paul, Dunning, Jake, Duplaix, Mathilde, Durante-Mangoni, Emanuele, Durham, Lucian, III, Dussol, Bertrand, Duthoit, Juliette, Duval, Xavier, Dyrhol-Riise, Anne Margarita, Ean, Sim Choon, Ebo, Ada, Echeverria-Villalobos, Marco, Edelstein, Michael, Egan, Siobhan, Eggesbø, Linn Margrete, Ehzaz, Khadeja, Eira, Carla, El Sanharawi, Mohammed, El Sayed, Marwan, Elabid, Mohammed, Elagili, Mohamed Bashir, Elapavaluru, Subbarao, Elbahnasawy, Mohammad, Elboshra, Sohail, Elharrar, Brigitte, Ellerbroek, Jacobien, Ellingjord-Dale, Merete, ELMagrahi, Hamida, Elmubark, Mohammad Muatasm, Elotmani, Loubna, Eloundou, Lauren, Eloy, Philippine, Elshaikhy, Basma, Elshazly, Tarek, Elsokni, Wafa, Eltayeb, Aml Ahmed, Elyazar, Iqbal, Emad, Zarief Kamel, Embarek, Hussein, Enderle, Isabelle, Endo, Tomoyuki, Eneli, Gervais, Eng, Chan Chee, Engelmann, Ilka, Enouf, Vincent, Epaulard, Olivier, Esaadi, Haneen, Esperatti, Mariano, Esperou, Hélène, Santo, Catarina Espírito, Esposito-Farese, Marina, Essaka, Rachel, Essuman, Lorinda, Estevão, João, Etienne, Manuel, Everding, Anna Greti, Evers, Mirjam, Fabre, Isabelle, Fabre, Marc, Fadera, Ismaila, Abdalla Fadlalla, Asgad Osman, Faheem, Amna, Fahy, Arabella, Fairfield, Cameron J., Fakar, Zul, Fareed, Komal, Faria, Pedro, Farooq, Ahmed, Fateena, Hanan, Fathi, Mohamed, Fatima, Salem, Fatoni, Arie Zainul, Faure, Karine, Favory, Raphaël, Fayed, Mohamed, Feely, Niamh, Fernandes, Jorge, Fernandes, Marília Andreia, Fernandes, Susana, Ferrand, François-Xavier, Devouge, Eglantine Ferrand, Ferrão, Joana, Ferraz, Mário, Ferreira, Benigno, Ferreira, Isabel, Ferreira, Bernardo, Ferreira, Sílvia, Ferriere, Nicolas, Ficko, Céline, Figueiredo-Mello, Claudia, Finlayson, William, Flament, Thomas, Fletcher, Tom, Florence, Aline-Marie, Florio, Letizia Lucia, Flynn, Brigid, Flynn, Deirdre, Foley, Jean, Fomin, Victor, Fonseca, Tatiana, Fontela, Patricia, Forrest, Karen, Forsyth, Simon, Foster, Denise, Foti, Giuseppe, Fotso, Berline, Fourn, Erwan, Fowler, Robert A., Fraher, Marianne, Franch-Llasat, Diego, Fraser, Christophe, Fraser, John F., Freire, Marcela Vieira, Ribeiro, Ana Freitas, French, Craig, Friedrich, Caren, Fritz, Ricardo, Fry, Stéphanie, Fuentes, Nora, Fukuda, Masahiro, Argin, G., Gaborieau, Valérie, Gaci, Rostane, Gagliardi, Massimo, Gagnard, Jean-Charles, Gagneux-Brunon, Amandine, Gai, Abdou, Gaião, Sérgio, Skeie, Linda Gail, Galal Mohamed Ramadan, Adham Mohamed, Gallagher, Phil, Gamble, Carrol, Gani, Yasmin, Garan, Arthur, Garcia, Rebekha, Garcia-Diaz, Julia, Garcia-Gallo, Esteban, Garimella, Navya, Garot, Denis, Garrait, Valérie, Gauli, Basanta, Gavrylov, Anatoliy, Gaymard, Alexandre, Gebauer, Johannes, Geraud, Eva, Morlaes, Louis Gerbaud, Germano, Nuno, Ghemmeid, Malak, Ghisulal, Praveen Kumar, Ghosn, Jade, Giani, Marco, Gigante, Tristan, Gilroy, Elaine, Giordano, Guillermo, Girvan, Michelle, Gissot, Valérie, Giwangkancana, Gezy, Glikman, Daniel, Glybochko, Petr, Gnall, Eric, Goco, Geraldine, Goehringer, François, Goepel, Siri, Goffard, Jean-Christophe, Goh, Jin Yi, Golács, Brigitta, Golob, Jonathan, Gomez, Kyle, Gómez-Junyent, Joan, Gominet, Marie, Gonzalez, Alicia, Gordon, Patricia, Gorenne, Isabelle, Goubert, Laure, Goujard, Cécile, Goulenok, Tiphaine, Grable, Margarite, Graf, Jeronimo, Grandin, Edward Wilson, Granier, Pascal, Grasselli, Giacomo, Grazioli, Lorenzo, Green, Christopher A., Greene, Courtney, Greenhalf, William, Greffe, Segolène, Grieco, Domenico Luca, Griffee, Matthew, Griffiths, Fiona, Grigoras, Ioana, Groenendijk, Albert, Grovogui, Fassou Mathias, Gruner, Heidi, Gu, Yusing, Guedj, Jérémie, Guego, Martin, Guerguerian, Anne-Marie, Guerreiro, Daniela, Guery, Romain, Guillaumot, Anne, Guilleminault, Laurent, Guimarães de Castro, Maisa, Guimard, Thomas, Haalboom, Marieke, Haber, Daniel, Hachemi, Ali, Haddud, Abdurrahman, Hadri, Nadir, Hafez, Wael, Haidri, Fakhir Raza, Rida Hajij, Fatima Mhd, Hakak, Sheeba, Hall, Adam, Hall, Matthew, Halpin, Sophie, Hamdan, Shaher, Hamdi, Abdelhafeez, Hameed, Jawad, Hamer, Ansley, Hamers, Raph L., Hamidfar, Rebecca, Hammarström, Bato, Hammond, Naomi, Hammond, Terese, Han, Lim Yuen, Hanan, Matly, Haniffa, Rashan, Hao, Kok Wei, Hardwick, Hayley, Harrison, Ewen M., Harrison, Janet, Ekow Harrison, Samuel Bernard, Hartman, Alan, Hasan, Sulieman, Nabil Hasan, Mohammad Ali, Hasan, Mohd Shahnaz, Hashmi, Junaid, Hashmi, Madiha, Hassan, Amoni, Hassanin, Ebtisam, Hayat, Muhammad, Hayes, Ailbhe, Hays, Leanne, Heerman, Jan, Heggelund, Lars, Helmi, Ahmed, Hendry, Ross, Hennessy, Martina, Henriquez-Trujillo, Aquiles Rodrigo, Hentzien, Maxime, Hernandez, Diana, Hershey, Andrew, Hesstvedt, Liv, Hidayah, Astarini, Higgins, Eibhlin, Higgins, Rupert, Hinton, Samuel, Hiraiwa, Hiroaki, Hirkani, Haider, Hitoto, Hikombo, Ho, Antonia, Ho, Yi Bin, Hoctin, Alexandre, Hoffmann, Isabelle, Hoh, Wei Han, Hoiting, Oscar, Holt, Rebecca, Holter, Jan Cato, Horby, Peter, Horcajada, Juan Pablo, Houas, Ikram, Houderi, Mabrouka, Hough, Catherine L., Houltham, Stuart, Ming-Yang Hsu, Jimmy, Hulot, Jean-Sébastien, Hurd, Abby, Hussain, Iqbal, Hussein, Aliae Mohamed, Hussein, Mahmood, Ibrahim, Fatima, Ibran, Bashir, Ijaz, Samreen, Ikram, M. Arfan, Illana, Carlos Cañada, Imbert, Patrick, Ansari, Muhammad Imran, Sikander, Rana Imran, Inácio, Hugo, Dominguez, Carmen Infante, Ing, Yun Sii, Ippolito, Mariachiara, Irawany, Vera, Isgett, Sarah, Isidoro, Tiago, Ismail, Nadiah, Isnard, Margaux, Istre, Mette Stausland, Itai, Junji, Ivulich, Daniel, Jaafar, Danielle, Jaafoura, Salma, Jaber, Hamza, Jabot, Julien, Jackson, Clare, Jagne, Abubacarr, Jaureguiberry, Stéphane, Jaworsky, Denise, Jego, Florence, Jelani, Anilawati Mat, Jenum, Synne, Jimbo-Sotomayor, Ruth, Joe, Ong Yiaw, Jorge García, Ruth Noemí, Jørgensen, Silje Bakken, Joseph, Cédric, Joseph, Mark, Joshi, Swosti, Jourdain, Mercé, Jouvet, Philippe, Jung, Anna, Jung, Hanna, Juzar, Dafsah, Kafif, Ouifiya, Kaguelidou, Florentia, Kaisbain, Neerusha, Kaleesvran, Thavamany, Kali, Sabina, Kalleberg, Karl Trygve, Kalomoiri, Smaragdi, Ayadi Kamaluddin, Muhammad Aisar, Kamano, Armand Saloun, Che Kamaruddin, Zul Amali, Kamarudin, Nadiah, Kamineni, Kavita, Kandamby, Darshana Hewa, Kang, Kong Yeow, Kanwal, Darakhshan, Kanyawati, Dyah, Karghul, Mohamed, Karpayah, Pratap, Karsies, Todd, Kartsonaki, Christiana, Kasugai, Daisuke, Katz, Kevin, Kay, Christy, Kayyali, Lamees, Keating, Seán, Kedia, Pulak, Kelly, Andrea, Kelly, Aoife, Kelly, Claire, Kelly, Niamh, Kelly, Sadie, Kelly, Yvelynne, Kelsey, Maeve, Kennon, Kalynn, Keomany, Sommay, Kernan, Maeve, Kerroumi, Younes, Keshav, Sharma, Khail, Shams, Khaled, Sarah, Khalid, Imrana, Khalil, Antoine, Khan, Irfan, Khan, Quratul Ain, Khanal, Sushil, Khatak, Abid, Kherajani, Krish, Kho, Michelle E., Khoo, Denisa, Khoo, Ryan, Khoo, Saye, Khoso, Muhammad Nasir, Khuwaja, Amin, Kiat, Khor How, Kida, Yuri, Kiiza, Peter, Granerud, Beathe Kiland, Kildal, Anders Benjamin, Kim, Jae Burm, Kimmoun, Antoine, Kindgen-Milles, Detlef, Kitamura, Nobuya, Kjetland Kjetland, Eyrun Floerecke, Klenerman, Paul, Klont, Rob, Bekken, Gry Kloumann, Knight, Stephen R., Kobbe, Robin, Forson, Paa Kobina, Kodippily, Chamira, Vasconcelos, Malte Kohns, Koirala, Sabin, Komatsu, Mamoru, Abebrese, Franklina Korkor, Korten, Volkan, Kouba, Stephanie, Kourouma, Mohamed Lamine, Kourouma, Karifa, Kpangon, Arsène, Krawczyk, Karolina, Kredan, Ali, Krishnan, Vinothini, Krishnan, Sudhir, Kruglova, Oksana, Krund, Anneli, Kuan, Pei Xuan, Kumar, Ashok, Kumar, Deepali, Kumar, Ganesh, Kumar, Mukesh, Kuriakose, Dinesh, Kurtzman, Ethan, Kutsogiannis, Demetrios, Kutsyna, Galyna, Bedu-Addo, Ama Kwakyewaa, Kwedi, Sylvie, Kyriakoulis, Konstantinos, Lachatre, Marie, Lacoste, Marie, Laffey, John G., Lafhej, Nadhem, Lagrange, Marie, Laine, Fabrice, Lairez, Olivier, Lakhey, Sanjay, Lambert, Marc, Lamontagne, François, Langelot-Richard, Marie, Langlois, Vincent, Lantang, Eka Yudha, Lanza, Marina, Laouénan, Cédric, Laribi, Samira, Lariviere, Delphine, Lasry, Stéphane, Lath, Sakshi, Latif, Naveed, Latifeh, Youssef, Launay, Odile, Laureillard, Didier, Lavie-Badie, Yoan, Law, Andy, Lawrence, Cassie, Lawrence, Teresa, Le, Minh, Le Bihan, Clément, Le Bris, Cyril, Le Falher, Georges, Le Fevre, Lucie, Le Hingrat, Quentin, Le Maréchal, Marion, Le Mestre, Soizic, Le Moal, Gwenaël, Le Moing, Vincent, Le Nagard, Hervé, Leal, Ema, Santos, Marta Leal, Lee, Biing Horng, Lee, Heng Gee, Lee, Su Hwan, Lee, James, Lee, Jennifer, Lee, Todd C., Lee, Yi Lin, Leeming, Gary, Lefebvre, Bénédicte, Lefebvre, Laurent, Lefèvre, Benjamin, LeGac, Sylvie, Lehiste, Merili-Helen, Lelievre, Jean-Daniel, Lellouche, François, Lemaignen, Adrien, Lemee, Véronique, Lemeur, Anthony, Lemmink, Gretchen, Lene, Ha Sha, Lennon, Jenny, León, Rafael, Leone, Marc, Lepik, Tanel, Lepiller, Quentin, Lescure, François-Xavier, Lesens, Olivier, Lesouhaitier, Mathieu, Lester-Grant, Amy, Letizia, Andrew, Letrou, Sophie, Levy, Bruno, Levy, Yves, Levy-Marchal, Claire, Lewandowska, Katarzyna, L'Her, Erwan, Bassi, Gianluigi Li, Liang, Janet, Liaquat, Ali, Liegeon, Geoffrey, Lim, Kah Chuan, Lim, Wei Shen, Lima, Chantre, Lina, Bruno, Lina, Lim, Lind, Andreas, Lingad, Maja Katherine, Lingas, Guillaume, Lion-Daolio, Sylvie, Liu, Keibun, Livrozet, Marine, Lizotte, Patricia, Loforte, Antonio, Lolong, Navy, Loon, Leong Chee, Lopes, Diogo, Lopez-Colon, Dalia, Loschner, Anthony L., Loubet, Paul, Loufti, Bouchra, Louis, Guillame, Lourenco, Silvia, Lovelace-Macon, Lara, Lee Low, Lee, Lowik, Marije, Loy, Jia Shyi, Lucet, Jean Christophe, Luna, Carlos M., Lungu, Olguta, Lunn, Miles, Luong, Liem, Luque, Nestor, Luton, Dominique, Maasikas, Olavi, Machado, Moïse, Machado, Sara, Macheda, Gabriel, Magzoub, Mustafa, Mahieu, Rafael, Mahy, Sophie, Maia, Ana Raquel, Maier, Lars S., Ascofare, Oumou Maiga, Maillet, Mylène, Maitre, Thomas, Majeed, Nimisha Abdul, Malfertheiner, Maximilian, Malik, Nadia, Mallon, Paddy, Maltez, Fernando, Malvy, Denis, Manda, Victoria, Mandelbrot, Laurent, Manetta, Frank, Mankikian, Julie, Manning, Edmund, Manuel, Aldric, Maráczi, Veronika, Sant′Ana Malaque, Ceila Maria, Marino, Flávio, Markowicz, Samuel, Marques, Ana, Marquis, Catherine, Marsh, Laura, Marsh, Brian, Marshal, Megan, Marshall, John, Martelli, Celina Turchi, Martin, Dori-Ann, Martin, Emily, Martin-Blondel, Guillaume, Martinelli, Alessandra, Martinez, F. Eduardo, Martin-Loeches, Ignacio, Martinot, Martin, Martín-Quiros, Alejandro, Martins, Ana, Martins, João, Martins, Nuno, Rego, Caroline Martins, Martucci, Gennaro, Martynenko, Olga, Marwali, Eva Miranda, Marzukie, Marsilla, Maslove, David, Mason, Sabina, Masood, Sobia, Masoud, Fatma, Massoma, Moise, Masumbe, Palmer, Mat Nor, Mohd Basri, Matan, Moshe, Fernandes, Henrique Mateus, Mathew, Meghena, Mathew, Christina, Mattei, Mathieu, Maulin, Laurence, May, Juergen, Maynar, Javier, Mayxay, Mayfong, Mazzoni, Thierry, Sweeney, Lisa Mc, McArthur, Colin, McCann, Naina, McCanny, Peter, McCarthy, Aine, McCarthy, Anne, McCloskey, Colin, McConnochie, Rachael, McDermott, Sherry, McDonald, Sarah E., McElroy, Aine, McElwee, Samuel, McEvoy, Natalie, McGeer, Allison, McLean, Kenneth A., McNally, Paul, McNicholas, Bairbre, Meaney, Edel, Mear-Passard, Cécile, Mechlin, Maggie, Medombou, Nastia, Mehkri, Omar, Mele, Ferruccio, Melo, Luis, Memon, Kashif Ali, Mendes, João João, Menkiti, Ogechukwu, Menon, Kusum, Mentré, France, Mentzer, Alexander J., Mercier, Emmanuelle, Mercier, Noémie, Merckx, Antoine, Mergeay-Fabre, Mayka, Mergler, Blake, Merson, Laura, Mesquita, António, Meta, Roberta, Metwally, Osama, Meybeck, Agnès, Meyer, Dan, Meynert, Alison M., Meysonnier, Vanina, Mezidi, Mehdi, Michelanglei, Céline, Michelet, Isabelle, Mihelis, Efstathia, Mihnovit, Vladislav, Abdullah, Duha Milad, Miller, Jennene, Miranda-Maldonado, Hugo, Misnan, Nor Arisah, Eliza Mohamed, Nik Nur, Mohamed, Nouralsabah, Mohamed, Tahira Jamal, Ads, Alaa Mohamed, Mohamed Elsayed Abdelhalim, Ahmed Reda, Mohammed, Libya, Mohammed Mostafa, Shrouk Fawze, Abdelrahman Mohammedahmed, Manahil Omer, Mohammedelhassan, Omer Abdullah, Moin, Asma, Mokhtar, Walaa, Molinos, Elena, Molloy, Brenda, Mone, Mary, Monteiro, Agostinho, Montes, Claudia, Montrucchio, Giorgia, Moore, Sarah, Moore, Shona C., Cely, Lina Morales, Morgom, Marwa, Moro, Lucia, Motherway, Catherine, Motos, Ana, Mouquet, Hugo, Perrot, Clara Mouton, Moyet, Julien, Mualla, Suleiman Haitham, Muftah, Mohamed, Mufti, Aisha Kalsoom, Muh, Ng Yong, Muhaisen, Mo'nes, Muhamad, Dzawani, Mullaert, Jimmy, Müller, Fredrik, Müller, Karl Erik, Munblit, Daniel, Ali, Syed Muneeb, Munir, Nadeem, Munshi, Laveena, Murphy, Aisling, Murray, Patrick, Murris, Marlène, Murthy, Srinivas, Musaab, Himed, Mustafa, Alamin, Mustafa, Mus'ab, Mustafa, Dana, Muvindi, Himasha, Myrodia, Dimitra Melia, Mohd-Hanafiah, Farah Nadia, Nadjm, Behzad, Nagpal, Dave, Nagrebetsky, Alex, Nagybányai-Nagy, Blanka, Boudoin, Herwin Nanda, Narasimhan, Mangala, Narayanan, Nageswaran, Nasa, Prashant, Khan, Rashid Nasim, Nasrallah, Ahmad, Nassif Metri, Adel Gerges, Nazerali-Maitland, Alasdair, Neant, Nadège, Neb, Holger, Nekliudov, Nikita, Nelder, Matthew, Nelwan, Erni, Neto, Raul, Neumann, Emily, Ng, Wing Yiu, Ng, Pauline Yeung, Nghi, Anthony, Nguyen, Duc, Choileain, Orna Ni, Leathlobhair, Niamh Ni, Niba, Nerissa, Nichol, Alistair D., Nitayavardhana, Prompak, Nonas, Stephanie, Mohd Noordin, Nurul Amani, Izzati Norharizam, Nurul Faten, North, Anita, Notari, Alessandra, Noursadeghi, Mahdad, Nowinski, Adam, Nseir, Saad, Numfor, Leonard, Nurnaningsih, Nurnaningsih, Nusantara, Dwi Utomo, Nyamankolly, Elsa, Nygaard, Anders Benteson, Brien, Fionnuala O., Callaghan, Annmarie O., O'Callaghan, Annmarie, Occhipinti, Giovanna, OConnor, Derbrenn, O'Donnell, Max, Ofori-Boadu, Lawrence, Ogston, Tawnya, Ogura, Takayuki, Oh, Tak-Hyuk, O'Halloran, Sophie, O'Hearn, Katie, Ohene, Sally-Ann, Ohshimo, Shinichiro, Oliveira, João, Oliveira, Larissa, Olliaro, Piero L., Rageh Elnaggar, Cinderella Omar, Mohammed Omer, Alsarrah Ali, Ondobo, Pierre, Ong, David S.Y., Ong, Jee Yan, Oosthuyzen, Wilna, Opavsky, Anne, Openshaw, Peter, Orakzai, Saijad, Orozco-Chamorro, Claudia Milena, Ortoleva, Jamel, Elsayed Soliman, Mohamed Osama, Osatnik, Javier, O'Shea, Linda, O'Sullivan, Miriam, Othman, Eman, Othman, Siti Zubaidah, Ouamara, Nadia, Ouissa, Rachida, Owusu, Micheal, Owusu-Asare, Ama Akyampomaa, Oziol, Eric, Pagadoy, Maïder, Pages, Justine, Palacios, Amanda, Palmarini, Massimo, Panarello, Giovanna, Panda, Prasan Kumar, Paneru, Hem, Pang, Lai Hui, Panigada, Mauro, Pansu, Nathalie, Papadopoulos, Aurélie, Parke, Rachael, Parker, Melissa, Pasquier, Jérémie, Pastene, Bruno, Patauner, Fabian, Patel, Drashti, Pathmanathan, Mohan Dass, Patrão, Luís, Patricio, Patricia, Patterson, Lisa, Pattnaik, Rajyabardhan, Paul, Christelle, Paul, Mical, Paulos, Jorge, Paxton, William A., Payen, Jean-François, Peake, Sandra L., Peariasamy, Kalaiarasu, Peek, Giles J., Peelman, Florent, Peiffer-Smadja, Nathan, Peigne, Vincent, Pejkovska, Mare, Pelosi, Paolo, Peltan, Ithan D., Pereira, Rui, Perez, Daniel, Perpoint, Thomas, Pesenti, Antonio, Pestre, Vincent, Petrou, Lenka, Petrovic, Michele, Petrov-Sanchez, Ventzislava, Pettersen, Frank Olav, Peytavin, Gilles, Philips, Richard Odame, Phonemixay, Ooyanong, Phoutthavong, Soulichanya, Piagnerelli, Michael, Picard, Walter, Picone, Olivier, de Piero, Maria, Piersma, Djura, Pimentel, Carlos, Pinto, Raquel, Pires, Catarina, Piroth, Lionel, Pitaloka, Ayodhia, Piubelli, Chiara, Pius, Riinu, Piva, Simone, Plantier, Laurent, Png, Hon Shen, Poissy, Julien, Pokeerbux, Ryadh, Poli, Sergio, Pollakis, Georgios, Ponscarme, Diane, Porto, Diego Bastos, Post, Andra-Maris, Postma, Douwe F., Povoa, Pedro, Póvoas, Diana, Powis, Jeff, Prapa, Sofia, Praphasiri, Viladeth, Preau, Sébastien, Prebensen, Christian, Preiser, Jean-Charles, Prinssen, Anton, Pritchard, Mark G., Dilanthi Priyadarshani, Gamage Dona, Proença, Lucia, Pudota, Sravya, Semedi, Bambang Pujo, Pulicken, Mathew, Puplampu, Peter, Purcell, Gregory, Quesada, Luisa, Quinones-Cardona, Vilmaris, Quist-Paulsen, Else, Quraishi, Mohammed, Qutishat, Fadi, Rabaa, Maia, Rabaud, Christian, Rabindrarajan, Ebenezer, Rafael, Aldo, Rafiq, Marie, Ragab, Abdelrahman, Rahardjani, Mutia, Ullah, Arslan Rahat, Haji Ab Rahman, Ahmad Kashfi, Rahman, Rozanah Abd, Rainieri, Fernando, Rajahram, Giri Shan, Ramachandran, Pratheema, Ramakrishnan, Nagarajan, Ramalho, José, Ramli, Ahmad Afiq, Rammaert, Blandine, Ramos, Grazielle Viana, Rana, Asim, Rangappa, Rajavardhan, Ranjan, Ritika, Rapp, Christophe, Rashan, Aasiyah, Rashan, Thalha, Rasheed, Ghulam, Rasmin, Menaldi, Rätsep, Indrek, Rau, Cornelius, Ravi, Tharmini, Raza, Ali, Real, Andre, Rebaudet, Stanislas, Redl, Sarah, Reeve, Brenda, Rehman, Attaur, Rehman Khalid, Muhammad Osama, Reikvam, Dag Henrik, Reis, Renato, Rello, Jordi, Remppis, Jonathan, Remy, Martine, Ren, Hongru, Renk, Hanna, Resseguier, Anne-Sophie, Revest, Matthieu, Rewa, Oleksa, Reyes, Luis Felipe, Ribeiro, Maria Ines, Ricchiuto, Antonia, Richardson, David, Richardson, Denise, Richier, Laurent, Atikah Ahmad Ridzuan, Siti Nurul, Rios, Ana L., Rishu, Asgar, Rispal, Patrick, Risso, Karine, Rivera Nuñez, Maria Angelica, Robba, Chiara, Roberto, André, Roberts, Stephanie, Roberts, Charles, Robertson, David L., Robineau, Olivier, Roca, Anna, Roche-Campo, Ferran, Rodari, Paola, Rodeia, Simão, 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Siaw-Frimpong, Moses, Sibiude, Jeanne, Sibounheuang, Bountoy, Siddig, Nidhal, Siddiqui, Atif, Siddiqui, Maqsood Ahmed, Sigfrid, Louise, Sillah, Fatoumata, Sillaots, Piret, Silva, Catarina, Silva, Maria Joao, Silva, Rogério, Lim Heng, Benedict Sim, Sin, Wai Ching, Sinatti, Dario, Singh, Mahendra, Singh, Punam, Sitompul, Pompini Agustina, Sivam, Karisha, Skogen, Vegard, Smith, Sue, Smood, Benjamin, Smyth, Coilin, Snacken, Morgane, So, Dominic, Soh, Tze Vee, Solberg, Lene Bergendal, Solomon, Joshua, Solomon, Tom, Somers, Emily, Sommet, Agnès, Song, Myung Jin, Song, Rima, Song, Tae, Chia, Jack Song, Søraas, Arne, Sotto, Albert, Soum, Edouard, Sousa, Ana Chora, Sousa, Marta, Uva, Maria Sousa, Souza-Dantas, Vicente, Sow, Mamadou Saliou, Sperry, Alexandra, Spinuzza, Elisabetta, Ruwan Sri Darshana, B. 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2024
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4. A multi-country analysis of COVID-19 hospitalizations by vaccination status

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Abdukahil, Sheryl Ann, Jabal, Kamal Abu, Salah, Nashat Abu, Airlangga, Eka, Hssain, Ali Ait, Akwani, Chika, Al Qasim, Eman, Alberti, Angela, Aldabbourosama, Osama, Alessi, Marta, Alex, Beatrice, Al-Fares, Abdulrahman, Aliudin, Jeffrey, Alkahlout, Mohammed, Almasri, Lana, Al-Saba’a, Yousef, Alves, Rita, Cabrita, Joana Alves, Amaral, Maria, Ampaw, Phoebe, Anchan, Aditya John, Angheben, Andrea, Arabi, Yaseen, Arcadipane, Antonio, Archambault, Patrick, Arenz, Lukas, Arora, Rakesh, Ashley, Elizabeth A., Atique, Anika, Atlowly, Moad, Bach, Benjamin, Baillie, John Kenneth, Baird, J. Kevin, Balan, Valeria, Barbalho, Renata, Barbosa, Nicholas Yuri, Barclay, Wendy S., Barnikel, Michaela, Beer, Netta, Begum, Husna, Bellemare, David, Beltrame, Anna, Bertoli, Giulia, Bianco, Claudia, Humaid, Felwa Bin, Bitton, Jonathan, Blier, Catherine, Bogaert, Debby, Borges, Diogo, Bouhmani, Dounia, Bounphiengsy, Thipsavanh, Bountthasavong, Latsaniphone, Klerk, Bianca Boxma-de, Monteiro, Filipa Brás, Brazzi, Luca, Buchtele, Nina, Buonsenso, Danilo, Burrell, Aidan, Bustos, Ingrid G., Cabrita, Joana, Caceres, Eder, Garcês, Rui Caetano, Campisi, Josie, Canepa, Cecilia, Caoili, Janice, Cardellino, Chiara Simona, Cardoso, Filipa, Cardoso, Filipe, Cardoso, Sofia, Carney, Gayle, Carrier, François Martin, Carson, Gail, Cascão, Mariana, Casimiro, José, Castañeda, Silvia, Castanheira, Nidyanara, Cattaneo, Paolo, Cavalin, Roberta, Cavayas, Alexandros, Cevik, Muge, Chaleunphon, Bounthavy, Chan, Adrienne, Chand, Meera, Chen, Anjellica, Cheng, Matthew Pellan, Chommanam, Danoy, Chow, Yock Ping, Christy, Nathaniel, Claure-Del Granado, Rolando, Clohisey, Sara, Codan, Cassidy, Connor, Marie, Cooke, Graham S., Copland, Mary, Corley, Amanda, Cortegiani, Andrea, Crowl, Gloria, Cruz, Claudina, Csete, Marc, Custodio, Paula, da Silva Filipe, Ana, Dagens, Andrew, Daley, Peter, Dalloul, Zaina, Dalton, Heidi, Dalton, Jo, Damas, Juliana, Daneman, Nick, Dankwa, Emmanuelle A., Dantas, Jorge, D'Aragon, Frédérick, De Rose, Cristina, de Silva, Thushan, Dechert, William, Denis, Emmanuelle, Dishon, Yael, k Dhangar, Docherty, Annemarie B., Donnelly, Christl A., Donohue, Chloe, Douangdala, Phouvieng, Douglas, James Joshua, Downer, Triona, Downing, Mark, Drake, Thomas, Dryden, Murray, Dubot-Pérès, Audrey, Dudman, Susanne, Dunning, Jake, Duplaix, Mathilde, Durham, Lucian, III, Dyrhol-Riise, Anne Margarita, Edelstein, Michael, Escher, Martina, Esperatti, Mariano, Santo, Catarina Espírito, Estevão, João, Faheem, Amna, Fairfield, Cameron J., Faria, Pedro, Farshait, Nataly, Fernandes, Jorge, Fernandes, Marília Andreia, Ferrão, Joana, Ferraz, Mário, Ferreira, Bernardo, Figueiredo-Mello, Claudia, Fletcher, Tom, Flynn, Brigid, Fontela, Patricia, Forsyth, Simon, Foti, Giuseppe, Fowler, Robert A., Franch-Llasat, Diego, Fraser, Christophe, Fraser, John F., Ribeiro, Ana Freitas, Friedrich, Caren, Fuentes, Nora, G, Argin, Skeie, Linda Gail, Gamble, Carrol, Garcês, Rui, Garcia-Diaz, Julia, Garcia-Gallo, Esteban, Gavin, Aisling, Germano, Nuno, Ghadimi, Moji, Ghisulal, Praveen Kumar, Giani, Marco, Gibson, Jess, Girvan, Michelle, Goco, Geraldine, Gómez-Junyent, Joan, Grable, Margarite, Green, Christopher A., Greenhalf, William, Griffiths, Fiona, Gruner, Heidi, Gu, Yusing, Guerguerian, Anne-Marie, Guerreiro, Daniela, Haber, Daniel, Habraken, Hannah, Hafez, Wael, Hall, Matthew, Halpin, Sophie, Hamdan, Shaher, Hamers, Raph L., Hamza, Summer, Hardwick, Hayley, Harrison, Janet, Hartman, Alan, Heggelund, Lars, Hendry, Ross, Hennessy, Martina, Hesstvedt, Liv, Higgins, Dawn, Higgins, Rupert, Hinton, Samuel, Ho, Antonia, Holter, Jan Cato, Horcajada, Juan Pablo, Ming-Yang Hsu, Jimmy, Hurd, Abby, Ijaz, Samreen, Illana, Carlos Cañada, Inácio, Hugo, Ippolito, Mariachiara, Isidoro, Tiago, Jaber, Hamza, Jackson, Clare, Jaworsky, Denise, Jenum, Synne, Jouvet, Philippe, Kalicinska, Alina, Kandel, Chris, Katz, Kevin, Kaur, Aasmine, Keating, Seán, Kelly, Andrea, Kelly, Sadie, Kennon, Kalynn, Keomany, Sommay, Khalid, Imrana, Kho, Michelle E., Khoo, Saye, Kiiza, Peter, Granerud, Beathe Kiland, Kildal, Anders Benjamin, Klenerman, Paul, Bekken, Gry Kloumann, Knight, Stephen R., Korten, Volkan, Kosgei, Caroline, Kumar, Deepali, Kutsogiannis, Demetrios, Lamontagne, François, Lanza, Marina, Law, Andrew, Law, Andy, Lawrence, Teresa, Lee, James, Lee, Jennifer, Lee, Todd C., Leeming, Gary, Letizia, Andrew, Bassi, Gianluigi Li, Liang, Janet, Lim, Wei Shen, Lind, Andreas, Lissauer, Samantha, Lopes, Diogo, Lyons, Ruth, Machado, Sara, Majeed, Nimisha Abdul, Manetta, Frank, Sant`Ana Malaque, Ceila Maria, Marquis, Catherine, Marsh, Laura, Marshall, John, Martín-Quiros, Alejandro, Martins, Ana, Rego, Caroline Martins, Martucci, Gennaro, Maslove, David, Matthew, Christina, Mayxay, Mayfong, McArthur, Colin, McCarthy, Anne, McConnochie, Rachael, McDonald, Sarah E., McGeer, Allison, McKay, Chris, McLean, Kenneth A., Menon, Kusum, Mentzer, Alexander J., Mesquita, António, Meyer, Dan, Meynert, Alison M., Mihelis, Efstathia, Monteiro, Agostinho, Montrucchio, Giorgia, Moore, Sarah, Moore, Shona C., Cely, Lina Morales, Moro, Lucia, Morton, Ben, Mudara, Caroline, Muhaisen, Mo’nes, Müller, Fredrik, Müller, Karl Erik, Munshi, Laveena, Murthy, Srinivas, Mustafa, Dana, Nagpal, Dave, Narasimhan, Mangala, Nasa, Prashant, Nelder, Matthew, Neumann, Emily, Ng, Pauline Yeung, Nichol, Alistair D., Norman, Lisa, Notari, Alessandra, Noursadeghi, Mahdad, Nusantara, Dwi Utomo, Occhipinti, Giovanna, O'Hearn, Katie, Oliveira, Larissa, Ong, David S.Y., Oosthuyzen, Wilna, Openshaw, Peter, Palmarini, Massimo, Panarello, Giovanna, Panda, Prasan Kumar, Parke, Rachael, Patricio, Patricia, Patterson, Lisa, Paul, Mical, Paulos, Jorge, Paxton, William A., Pejkovska, Mare, Pereira, Rui, Petrovic, Michele, Pettersen, Frank Olav, Pharand, Scott, Phonemixay, Ooyanong, Phoutthavong, Soulichanya, de Piero, Maria, Pimentel, Carlos, Pires, Catarina, Pitaloka, Ayodhia, Pius, Riinu, Poli, Sergio, Pollakis, Georgios, Post, Andra-Maris, Póvoas, Diana, Powis, Jeff, Praphasiri, Viladeth, Pritchard, Mark G., Semedi, Bambang Pujo, Purcell, Gregory, Quesada, Luisa, Quist-Paulsen, Else, Rafael, Aldo, Rahardjani, Mutia, Ramalho, José, Rangappa, Rajavardhan, Rätsep, Indrek, Reeve, Brenda, Reikvam, Dag Henrik, Ren, Hongru, Rewa, Oleksa, Ricchiuto, Antonia, Rishu, Asgar, Rivera Nuñez, Maria Angelica, Roberts, Stephanie, Robertson, David L., Roche-Campo, Ferran, Rodari, Paola, Roessler, Bernhard, Rossanese, Andrea, Rossetti, Matteo, Russell, Clark D., Holten, Aleksander Rygh, Saba, Isabela, Sadat, Musharaf, Sahraei, Valla, Salazar, Leonardo, Sales, Gabriele, Sanchez, Emely, Sancho-Shimizu, Vanessa, Sandhu, Gyan, Sandulescu, Oana, Santos, Marlene, Sarfo-Mensah, Shirley, Sarmiento, Iam Claire E., Saviciute, Egle, Schaffer, Justin, Schwameis, Michael, Schwartz, Gary, Scott, Janet T., Scott-Brown, James, Semple, Malcolm G., Sequeira, Tânia, Shadowitz, Ellen, Shankar, Anuraj, Shaw, Catherine A., Shaw, Victoria, Mohan Shetty, Dr. Rajesh, Sibounheuang, Bountoy, Sigfrid, Louise, Sillaots, Piret, Sin, Wai Ching, Sinatti, Dario, Singh, Mahendra, Skogen, Vegard, Smith, Sue, Solomon, Joshua, Solomon, Tom, Song, Rima, Spinuzza, Elisabetta, Sriskandan, Shiranee, Staudinger, Thomas, Stecher, Stephanie-Susanne, Steinsvik, Trude, Stiksrud, Birgitte, Streinu-Cercel, Adrian, Streinu-Cercel, Anca, Stuart, David, Subekti, Decy, Suen, Jacky Y., Sultana, Asfia, Summers, Charlotte, Suwarti, Atie, Sztajnbok, Jaques, Tabrizi, Shirin, Taleb, Sara, Tedder, Richard S., Teixeira, João, Tessier-Grenier, Hubert, Thompson, Shaun, Thomson, Emma C., Thorpe, Mathew, Thwaites, Ryan S., Tonby, Kristian, Torre, Marta, Torres Santos-Olmo, Rosario Maria, Turgeon, Alexis F., Turtle, Lance C.W., Tveita, Anders, Twardowski, Pawel, Ullrich, Roman, Uyeki, Timothy M., Valentini, Piero, Val-Flores, Luís, Varrone, Michael, Vidal, José Ernesto, Vieira, César, Villanueva, Joy Ann, Villar, Judit, Villoldo, Andrea, Vitiello, Chiara, Vongsouvath, Manivanh, Wainstein, Marina, Webb, Steve, Wei, Jia, Wesselius, Sanne, Wham, Murray, White, Nicole, Willems, Sue, Williams, Bailey, Williams, Virginie, Wils, Evert-Jan, Wittman, Jessica, Yerkovich, Stephanie, Yiaye, Touxiong, Zahran, Maram, Zambon, Maria, Gonçalves, Bronner P., Jassat, Waasila, Baruch, Joaquín, Hashmi, Madiha, Rojek, Amanda, Dasgupta, Abhishek, Martin-Loeches, Ignacio, Reyes, Luis Felipe, Piubelli, Chiara, Citarella, Barbara Wanjiru, Kartsonaki, Christiana, Lefèvre, Benjamin, López Revilla, José W., Lunn, Miles, Harrison, Ewen M., Kraemer, Moritz U.G., Shrapnel, Sally, Horby, Peter, Bisoffi, Zeno, Olliaro, Piero L., and Merson, Laura

Published
2023
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5. Major adverse cardiovascular events (MACE) in patients with severe COVID-19 registered in the ISARIC WHO clinical characterization protocol: A prospective, multinational, observational study

Author

Reyes, Luis Felipe, Garcia-Gallo, Esteban, Murthy, Srinivas, Fuentes, Yuli V., Serrano, Cristian C., Ibáñez-Prada, Elsa D., Lee, James, Rojek, Amanda, Citarella, Barbara Wanjiru, Gonçalves, Bronner P., Dunning, Jake, Rätsep, Indrek, Viñan-Garces, Andre Emilio, Kartsonaki, Christiana, Rello, Jordi, Martin-Loeches, Ignacio, Shankar-Hari, Manu, Olliaro, Piero L., and Merson, Laura

Published
2023
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7. What more can be done? Prioritizing the most promising antenatal interventions to improve birth weight

Author

Awoyemi, Toluwalase, Ayede, Adejumoke I., Bastola, Kalpana, Bhutta, Zulfiqar A., Blencowe, Hannah, Christian, Parul, David, Anna, Hunter, Patricia, Isojärvi, Jaana, Katz, Joanne, De Costa, Ayesha, Erchick, Daniel J., Gibson, Sarah, Goncalves, Bronner P., Gravett, Michael G., Hadji, Maryam, Hazel, Elizabeth, Hofmeyr, G Justus, Kozuki, Naoko, Lee, Anne CC., Magge, Hema, Manasyan, Albert, Mohiddin, Abdulrahman, Morrison, Melissa, Muthiani, Yvonne, Nabwera, Helen, Nakimuli, Annettee, Okong, Pius, Prendergast, Andrew J., Simon, Jonathon, Temmerman, Marleen, Yan, Jian, Koivu, Annariina M., Haapaniemi, Tiia, Askari, Sufia, Bhandari, Nita, Black, Robert E., Chico, R. Matthew, Dewey, Kathryn G., Duggan, Christopher P., Klein, Nigel, Kumar, Somesh, Lawn, Joy E., Manji, Karim, Näsänen-Gilmore, Pieta K., Salasibew, Mihretab, Semrau, Katherine E.A., Ashorn, Ulla, and Ashorn, Per

Published
2023
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8. Neurodevelopmental and growth outcomes after invasive Group B Streptococcus in early infancy: A multi-country matched cohort study in South Africa, Mozambique, India, Kenya, and Argentina

Author

Madhi, Shabir A., Dangor, Ziyaad, Leahy, Shannon, Harden, Lois, Ghoor, Azra, Mbatha, Sibongile, Lowick, Sarah, Laughton, Barbara, Jaye, Tamara, Lala, Sanjay G, Sithole, Pamela, Msayi, Jacqueline, Kumalo, Ntombifuthi, Msibi, Tshepiso Nompumelelo, Santhanam, Sridhar, John, Hima B., Arumugam, Asha, Murugesan, Nandhini, Rajendraprasad, Nandhini, Priya, Mohana, Abubakar, Amina, Nasambu, Carophine, Adan, Adam Mabrouk, Katana, Patrick Vidzo, Mwangome, Eva, Newton, Charles R., Bassat, Quique, Bardají, Azucena, Bramugy, Justina, Mucasse, Humberto, Aerts, Celine, Massora, Sergio, Libster, Romina, Yanotti, Clara Sánchez, Medina, Valeria, Rojas, Andrea, Amado, Daniel, Llapur, Conrado J., Hossain, A.K.M. Tanvir, Sadeq-ur Rahman, Qazi, Paul, Proma, Chandna, Jaya, Procter, Simon R., Seedat, Farah, Horváth-Puhó, Erzsébet, Jit, Mark, Milner, Kate, Gonçalves, Bronner P., and Lawn, Joy E.

Published
2022
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9. Priority use cases for antibody-detecting assays of recent malaria exposure as tools to achieve and sustain malaria elimination

Author

Greenhouse, Bryan, Daily, Jennifer, Guinovart, Caterina, Goncalves, Bronner, Beeson, James, Bell, David, Chang, Michelle A, Cohen, Justin M, Ding, Xavier, Domingo, Gonzalo, Eisele, Thomas P, Lammie, Patrick J, Mayor, Alfredo, Merienne, Nicolas, Monteiro, Wuelto, Painter, John, Rodriguez, Isabel, White, Michael, Drakeley, Chris, and Mueller, Ivo

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Rare Diseases, Malaria, Vector-Borne Diseases, Infectious Diseases, Biotechnology, HIV/AIDS, Detection, screening and diagnosis, 4.4 Population screening, Infection, Good Health and Well Being, Malaria Serology Convening, Elimination, Serology, Use Cases, Biomedical and clinical sciences, Health sciences
Abstract

Measurement of malaria specific antibody responses represents a practical and informative method for malaria control programs to assess recent exposure to infection. Technical advances in recombinant antigen production, serological screening platforms, and analytical methods have enabled the identification of several target antigens for laboratory based and point-of-contact tests. Questions remain as to how these serological assays can best be integrated into malaria surveillance activities to inform programmatic decision-making. This report synthesizes discussions from a convening at Institut Pasteur in Paris in June 2017 aimed at defining practical and informative use cases for serology applications and highlights five programmatic uses for serological assays including: documenting the absence of transmission; stratification of transmission; measuring the effect of interventions; informing a decentralized immediate response;  and testing and treating P. vivax hypnozoite carriers.

Published
2019

13. Transmission of molecularly undetectable circulating parasite clones leads to high infection complexity in mosquitoes post feeding

Author

Grignard, Lynn, Gonçalves, Bronner P., Early, Angela M., Daniels, Rachel F., Tiono, Alfred B., Guelbéogo, Wamdaogo M., Ouédraogo, Alphonse, van Veen, Elke M., Lanke, Kjerstin, Diarra, Amidou, Nebie, Issa, Sirima, Sodiomon B., Targett, Geoff A., Volkman, Sarah K., Neafsey, Daniel E., Wirth, Dyann F., Bousema, Teun, and Drakeley, Chris

Published
2018
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19. Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide : a systematic review and meta-analysis of individual patient data

Author

Stepniewska, Kasia, Allen, Elizabeth N., Humphreys, Georgina S., Poirot, Eugenie, Craig, Elaine, Kennon, Kalynn, Yilma, Daniel, Bousema, Teun, Guerin, Philippe J., White, Nicholas J., Price, Ric N., Raman, Jaishree, Mårtensson, Andreas, Mwaiswelo, Richard O., Bancone, Germana, Bastiaens, Guido J. H., Bjorkman, Anders, Brown, Joelle M., D'Alessandro, Umberto, Dicko, Alassane A., El-Sayed, Badria, Elzaki, Salah-Eldin, Eziefula, Alice C., Goncalves, Bronner P., Hamid, Muzamil Mahdi Abdel, Kaneko, Akira, Kariuki, Simon, Khan, Wasif, Kwambai, Titus K., Ley, Benedikt, Ngasala, Billy E., Nosten, Francois, Okebe, Joseph, Samuels, Aaron M., Smit, Menno R., Stone, Will J. R., Sutanto, Inge, Ter Kuile, Feiko, Tine, Roger C., Tiono, Alfred B., Drakeley, Chris J., Gosling, Roly, Stergachis, Andy, Barnes, Karen, I, Chen, Ingrid, Stepniewska, Kasia, Allen, Elizabeth N., Humphreys, Georgina S., Poirot, Eugenie, Craig, Elaine, Kennon, Kalynn, Yilma, Daniel, Bousema, Teun, Guerin, Philippe J., White, Nicholas J., Price, Ric N., Raman, Jaishree, Mårtensson, Andreas, Mwaiswelo, Richard O., Bancone, Germana, Bastiaens, Guido J. H., Bjorkman, Anders, Brown, Joelle M., D'Alessandro, Umberto, Dicko, Alassane A., El-Sayed, Badria, Elzaki, Salah-Eldin, Eziefula, Alice C., Goncalves, Bronner P., Hamid, Muzamil Mahdi Abdel, Kaneko, Akira, Kariuki, Simon, Khan, Wasif, Kwambai, Titus K., Ley, Benedikt, Ngasala, Billy E., Nosten, Francois, Okebe, Joseph, Samuels, Aaron M., Smit, Menno R., Stone, Will J. R., Sutanto, Inge, Ter Kuile, Feiko, Tine, Roger C., Tiono, Alfred B., Drakeley, Chris J., Gosling, Roly, Stergachis, Andy, Barnes, Karen, I, and Chen, Ingrid

Abstract

Background In 2012, the World Health Organization (WHO) recommended single low-dose (SLD, 0.25 mg/kg) primaquine to be added as a Plasmodium (P.) falciparum gametocytocide to artemisinin-based combination therapy (ACT) without glucose-6-phosphate dehydrogenase (G6PD) testing, to accelerate malaria elimination efforts and avoid the spread of artemisinin resistance. Uptake of this recommendation has been relatively slow primarily due to safety concerns. Methods A systematic review and individual patient data (IPD) meta-analysis of single-dose (SD) primaquine studies for P. falciparum malaria were performed. Absolute and fractional changes in haemoglobin concentration within a week and adverse effects within 28 days of treatment initiation were characterised and compared between primaquine and no primaquine arms using random intercept models. Results Data comprised 20 studies that enrolled 6406 participants, of whom 5129 (80.1%) had received a single target dose of primaquine ranging between 0.0625 and 0.75 mg/kg. There was no effect of primaquine in G6PD-normal participants on haemoglobin concentrations. However, among 194 G6PD-deficient African participants, a 0.25 mg/kg primaquine target dose resulted in an additional 0.53 g/dL (95% CI 0.17-0.89) reduction in haemoglobin concentration by day 7, with a 0.27 (95% CI 0.19-0.34) g/dL haemoglobin drop estimated for every 0.1 mg/kg increase in primaquine dose. Baseline haemoglobin, young age, and hyperparasitaemia were the main determinants of becoming anaemic (Hb < 10 g/dL), with the nadir observed on ACT day 2 or 3, regardless of G6PD status and exposure to primaquine. Time to recovery from anaemia took longer in young children and those with baseline anaemia or hyperparasitaemia. Serious adverse haematological events after primaquine were few (9/3, 113, 0.3%) and transitory. One blood transfusion was reported in the primaquine arms, and there were no primaquine-related deaths. In controlled studies, the proportions

Published
2022
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20. What more can be done? Prioritizing the most promising antenatal interventions to improve birth weight

Author

Koivu, Annariina M., Haapaniemi, Tiia, Askari, Sufia, Bhandari, Nita, Black, Robert E., Chico, R. Matthew, Dewey, Kathryn G., Duggan, Christopher P., Klein, Nigel, Kumar, Somesh, Lawn, Joy E., Manji, Karim, Näsänen-Gilmore, Pieta K., Salasibew, Mihretab, Semrau, Katherine E.A., Ashorn, Ulla, Ashorn, Per, Awoyemi, Toluwalase, Ayede, Adejumoke I., Bastola, Kalpana, Bhutta, Zulfiqar A., Blencowe, Hannah, Christian, Parul, David, Anna, Hunter, Patricia, Isojärvi, Jaana, Katz, Joanne, De Costa, Ayesha, Erchick, Daniel J., Gibson, Sarah, Goncalves, Bronner P., Gravett, Michael G., Hadji, Maryam, Hazel, Elizabeth, Hofmeyr, G Justus, Kozuki, Naoko, Lee, Anne CC., Magge, Hema, Manasyan, Albert, Mohiddin, Abdulrahman, Morrison, Melissa, Muthiani, Yvonne, Nabwera, Helen, Nakimuli, Annettee, Okong, Pius, Prendergast, Andrew J., Simon, Jonathon, Temmerman, Marleen, and Yan, Jian

Abstract

Low birth weight (LBW) is associated with neonatal mortality and sequelae of lifelong health problems; prioritizing the most promising antenatal interventions may guide resource allocation and improve health outcomes.

Published
2023
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21. Model-based assessment of the safety of community interventions with primaquine in sub-Saharan Africa

Author

van Beek, Stijn W., Svensson, Elin, Tiono, Alfred B., Okebe, Joseph, D'Alessandro, Umberto, Goncalves, Bronner P., Bousema, Teun, Drakeley, Chris, ter Heine, Rob, van Beek, Stijn W., Svensson, Elin, Tiono, Alfred B., Okebe, Joseph, D'Alessandro, Umberto, Goncalves, Bronner P., Bousema, Teun, Drakeley, Chris, and ter Heine, Rob

Abstract

Background Single low-dose primaquine (SLD-PQ) is recommended in combination with artemisinin-based combination therapy to reduce Plasmodium falciparum transmission in areas threatened by artemisinin resistance or aiming for malaria elimination. SLD-PQ may be beneficial in mass drug administration (MDA) campaigns to prevent malaria transmission but uptake is limited by concerns of hemolysis in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals. The aim of this study was to improve the evidence on the safety of MDA with SLD-PQ in a sub-Saharan African setting. Methods A nonlinear mixed-effects model describing the pharmacokinetics and treatment-induced hemolysis of primaquine was developed using data from an adult (n = 16, G6PD deficient) and pediatric study (n = 38, G6PD normal). The relationship between primaquine pharmacokinetics and hemolysis was modeled using an established erythrocyte lifespan model. The safety of MDA with SLD-PQ was explored through Monte Carlo simulations for SLD-PQ at 0.25 or 0.4 mg/kg using baseline data from a Tanzanian setting with detailed information on hemoglobin concentrations and G6PD status. Results The predicted reduction in hemoglobin levels following SLD-PQ was small and returned to pre-treatment levels after 25 days. G6PD deficiency (African A- variant) was associated with a 2.5-fold (95% CI 1.2-8.2) larger reduction in hemoglobin levels. In the Tanzanian setting where 43% of the population had at least mild anemia (hemoglobin < 11-13 g/dl depending on age and sex) and 2.73% had severe anemia (hemoglobin < 7-8 g/dl depending on age and sex), an additional 3.7% and 6.0% of the population were predicted to develop at least mild anemia and 0.25% and 0.41% to develop severe anemia after 0.25 and 0.4 mg/kg SLD-PQ, respectively. Children < 5 years of age and women >= 15 years of age were found to have a higher chance to have low pre-treatment hemoglobin. Conclusions This study supports the feasibility of MDA wi

Published
2021
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22. Validation of BCL11A As Therapeutic Target in Sickle Cell Disease: Results from the Adult Cohort of a Pilot/Feasibility Gene Therapy Trial Inducing Sustained Expression of Fetal Hemoglobin Using Post-Transcriptional Gene Silencing

Author

Esrick, Erica B., primary, Achebe, Maureen, additional, Armant, Myriam, additional, Bartolucci, Pablo, additional, Ciuculescu, Marioara Felicia, additional, Daley, Heather, additional, Dansereau, Colleen, additional, Di Caprio, Giuseppe, additional, Goncalves, Bronner, additional, Hebert, Nicolas, additional, Heeney, Matthew M, additional, Higgins, John M., additional, Lehmann, Leslie E., additional, Manis, John P, additional, Negre, Olivier, additional, Nikiforow, Sarah, additional, Schonbrun, Ethan, additional, Wood, David K., additional, and Williams, David A., additional

Published
2019
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23. MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease

Author

Demers, Melanie, primary, Sturtevant, Sarah, additional, Guertin, Kevin, additional, Gupta, Dipti, additional, Desai, Kunal, additional, Vieira, Benjamin, additional, Hicks, Alexandra, additional, Ismail, Ayman, additional, Nakamura, Yukio, additional, Goncalves, Bronner, additional, Di Caprio, Giuseppe, additional, Schonbrun, Ethan, additional, Hansen, Scott, additional, Safo, Martin K., additional, Wood, David K., additional, Higgins, John M., additional, and Light, David R., additional

Published
2019
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25. Safety of single low-dose primaquine in glucose-6-phosphate dehydrogenase deficient falciparum-infected African males: Two open-label, randomized, safety trials

Author

Bastiaens, Guido J. H., Tiono, Alfred B., Okebe, Joseph, Pett, Helmi E., Coulibaly, Sam A., Goncalves, Bronner P., Affara, Muna, Ouedraogo, Alphonse, Bougouma, Edith C., Sanou, Guillaume S., Nebie, Issa, Bradley, John, Lanke, Kjerstin H. W., Niemi, Mikko, Sirima, Sodiomon B., d'Alessandro, Umberto, Bousema, Teun, Drakeley, Chris, Clinicum, Department of Clinical Pharmacology, Medicum, University of Helsinki, and HUSLAB

Subjects
TRANSMISSION, lcsh:R, REDUCE GAMETOCYTE CARRIAGE, PLASMODIUM-VIVAX MALARIA, lcsh:Medicine, CHILDREN, G6PD DEFICIENCY, DOUBLE-BLIND, ARTEMETHER-LUMEFANTRINE, 3121 General medicine, internal medicine and other clinical medicine, parasitic diseases, lcsh:Q, 3111 Biomedicine, DIHYDROARTEMISININ-PIPERAQUINE, CYP 2D6, lcsh:Science, DRUG DEVELOPMENT
Abstract

BACKGROUND: Primaquine (PQ) actively clears mature Plasmodium falciparum gametocytes but in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals can cause hemolysis. We assessed the safety of low-dose PQ in combination with artemether-lumefantrine (AL) or dihydroartemisinin-piperaquine (DP) in G6PDd African males with asymptomatic P. falciparum malaria. METHODS AND FINDINGS: In Burkina Faso, G6PDd adult males were randomized to treatment with AL alone (n = 10) or with PQ at 0.25 (n = 20) or 0.40 mg/kg (n = 20) dosage; G6PD-normal males received AL plus 0.25 (n = 10) or 0.40 mg/kg (n = 10) PQ. In The Gambia, G6PDd adult males and boys received DP alone (n = 10) or with 0.25 mg/kg PQ (n = 20); G6PD-normal males received DP plus 0.25 (n = 10) or 0.40 mg/kg (n = 10) PQ. The primary study endpoint was change in hemoglobin concentration during the 28-day follow-up. Cytochrome P-450 isoenzyme 2D6 (CYP2D6) metabolizer status, gametocyte carriage, haptoglobin, lactate dehydrogenase levels and reticulocyte counts were also determined. In Burkina Faso, the mean maximum absolute change in hemoglobin was -2.13 g/dL (95% confidence interval [CI], -2.78, -1.49) in G6PDd individuals randomized to 0.25 PQ mg/kg and -2.29 g/dL (95% CI, -2.79, -1.79) in those receiving 0.40 PQ mg/kg. In The Gambia, the mean maximum absolute change in hemoglobin concentration was -1.83 g/dL (95% CI, -2.19, -1.47) in G6PDd individuals receiving 0.25 PQ mg/kg. After adjustment for baseline concentrations, hemoglobin reductions in G6PDd individuals in Burkina Faso were more pronounced compared to those in G6PD-normal individuals receiving the same PQ doses (P = 0.062 and P = 0.022, respectively). Hemoglobin levels normalized during follow-up. Abnormal haptoglobin and lactate dehydrogenase levels provided additional evidence of mild transient hemolysis post-PQ. CONCLUSIONS: Single low-dose PQ in combination with AL and DP was associated with mild and transient reductions in hemoglobin. None of the study participants developed moderate or severe anemia; there were no severe adverse events. This indicates that single low-dose PQ is safe in G6PDd African males when used with artemisinin-based combination therapy. TRIAL REGISTRATION: Clinicaltrials.gov NCT02174900 Clinicaltrials.gov NCT02654730.

Published
2018

27. Impact of Changing Drug Treatment and Malaria Endemicity on the Heritability of Malaria Phenotypes in a Longitudinal Family-Based Cohort Study

Author

Loucoubar, Cheikh, primary, Goncalves, Bronner, additional, Tall, Adama, additional, Sokhna, Cheikh, additional, Trape, Jean-François, additional, Diène Sarr, Fatoumata, additional, Faye, Joseph, additional, Badiane, Abdoulaye, additional, Ly, Alioune Badara, additional, Diop, Aliou, additional, Bar-Hen, Avner, additional, Bureau, Jean-François, additional, Sakuntabhai, Anavaj, additional, and Paul, Richard, additional

Published
2011
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29. The West Africa Lassa fever Consortium pre-positioned protocol for a Phase II/III adaptive, randomised, controlled, platform trial to evaluate multiple Lassa fever therapeutics.

Author

Bourner J, Salam AP, Jaspard M, Olayinka A, Fritzell C, Goncalves B, Vaillant M, Edwards T, Erameh C, Ajayi N, Ramharter M, and Olliaro P

Abstract

Background : This is a standardized, pre-positioned protocol for the coordinated evaluation of Lassa fever therapeutics. The protocol is the product of discussions that took place in 2021 and 2022 among international investigators from a wide range of scientific and medical disciplines working together within the West Africa Lassa fever Consortium (WALC). Methods : This is a clinical Phase II/III multicentre randomised controlled platform trial using a superiority framework with an equal allocation ratio and a composite primary endpoint of all-cause mortality OR new onset of i) acute kidney failure (AKF), OR ii) acute respiratory failure (ARF), OR iii) shock assessed from enrolment (D0) to D28. Discussion : This pre-positioned protocol was developed by the WALC and made available for adaptation and implementation by the wider Lassa fever research community in order to generate efficient, reliable, and comparable evidence for Lassa fever therapeutics., Competing Interests: No competing interests were disclosed., (Copyright: © 2023 Bourner J et al.)

Published
2023
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30. Priority use cases for antibody-detecting assays of recent malaria exposure as tools to achieve and sustain malaria elimination.

Author

Greenhouse B, Daily J, Guinovart C, Goncalves B, Beeson J, Bell D, Chang MA, Cohen JM, Ding X, Domingo G, Eisele TP, Lammie PJ, Mayor A, Merienne N, Monteiro W, Painter J, Rodriguez I, White M, Drakeley C, and Mueller I

Abstract

Measurement of malaria specific antibody responses represents a practical and informative method for malaria control programs to assess recent exposure to infection. Technical advances in recombinant antigen production, serological screening platforms, and analytical methods have enabled the identification of several target antigens for laboratory based and point-of-contact tests. Questions remain as to how these serological assays can best be integrated into malaria surveillance activities to inform programmatic decision-making. This report synthesizes discussions from a convening at Institut Pasteur in Paris in June 2017 aimed at defining practical and informative use cases for serology applications and highlights five programmatic uses for serological assays including: documenting the absence of transmission; stratification of transmission; measuring the effect of interventions; informing a decentralized immediate response;   and testing and treating P. vivax hypnozoite carriers., Competing Interests: No competing interests were disclosed.

Published
2019
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