1. Genetic Clustering of Tuberculosis in an Indigenous Community of Brazil.
- Author
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Correia Sacchi FP, Tatara MB, Camioli de Lima C, Ferreia da Silva L, Cunha EA, Simonsen V, Ferrazoli L, Gomes HM, Gonçalves Vasconcellos SE, Suffys PN, Andrews JR, and Croda J
- Subjects
- Adult, Brazil epidemiology, Brazil ethnology, Contact Tracing, Family Characteristics ethnology, Female, Humans, Male, Middle Aged, Molecular Epidemiology, Multivariate Analysis, Population Groups ethnology, Risk Factors, Surveys and Questionnaires, Tuberculosis epidemiology, Tuberculosis ethnology, Cluster Analysis, Population Groups statistics & numerical data, Tuberculosis genetics
- Abstract
We conducted a population-based study of tuberculosis (TB) from 2009 to 2015 in an indigenous community of Brazil, the largest in the country, to investigate risk factors associated with recent TB transmission. The clinical isolates of Mycobacterium tuberculosis were genotyped by IS 6110 -RFLP (restriction fragment length polymorphism) and spoligotyping analysis. Among 67 isolates typed by RFLP, 69% fell into fifteen clusters, and 91% of TB cases with shared IS 6110 -RFLP pattern were diagnosed within 2 years of another case in the cluster. Individual risk factors associated with genetic clustering were domestic overcrowding (odds ratio [OR]: 6.10; 95% confidence interval [CI]: 1.50-24.88) and low social class (OR: 3.72; 95% CI: 1.00-13.98). Most reported contacts (76%) were identified within the household of the index TB case, but most of the genetic clustering of M. tuberculosis occurred outside of household (79%). Expanded contacts investigation and prophylaxis outside of household should be considered as a priority for TB control programs in this population.
- Published
- 2018
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