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307 results on '"Gomis, Roger R."'

1. MAF amplification licenses ERα through epigenetic remodelling to drive breast cancer metastasis

Author

Llorente, Alicia, Blasco, María Teresa, Espuny, Irene, Guiu, Marc, Ballaré, Cecilia, Blanco, Enrique, Caballé, Adrià, Bellmunt, Anna, Salvador, Fernando, Morales, Andrea, Nuñez, Marc, Loren, Guillem, Imbastari, Francesca, Fidalgo, Marta, Figueras-Puig, Cristina, Gibler, Patrizia, Graupera, Mariona, Monteiro, Freddy, Riera, Antoni, Holen, Ingunn, Avgustinova, Alexandra, Di Croce, Luciano, and Gomis, Roger R.

Published
2023
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2. Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy

Author

Linares, Jenniffer, Sallent-Aragay, Anna, Badia-Ramentol, Jordi, Recort-Bascuas, Alba, Méndez, Ana, Manero-Rupérez, Noemí, Re, Daniele Lo, Rivas, Elisa I., Guiu, Marc, Zwick, Melissa, Iglesias, Mar, Martinez-Ciarpaglini, Carolina, Tarazona, Noelia, Varese, Monica, Hernando-Momblona, Xavier, Cañellas-Socias, Adrià, Orrillo, Mayra, Garrido, Marta, Saoudi, Nadia, Elez, Elena, Navarro, Pilar, Tabernero, Josep, Gomis, Roger R., Batlle, Eduard, Pisonero, Jorge, Cervantes, Andres, Montagut, Clara, and Calon, Alexandre

Published
2023
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3. The transcriptional landscape of metastatic hormone-naive prostate cancer

Author

Martin-Martin, Natalia, primary, Garcia-Longarte, Saioa, additional, Corres-Mendizabal, Jon, additional, Lazcano, Uxue, additional, Astobiza, Ianire, additional, Bozal-Basterra, Laura, additional, Herranz, Nicolas, additional, van Splunder, Hielke, additional, Carlevaris, Onintza, additional, Pujana-Vaquerizo, Mikel, additional, Blasco, María Teresa, additional, Aransay, Ana M., additional, Rosino, Antonio, additional, Tudela, Julian, additional, Jimenez, Daniel, additional, Martinez, Alberto, additional, Salca, Andrei, additional, Santos-Martín, Aida, additional, Rey, Sofía, additional, Ugalde-Olano, Aitziber, additional, Gonzalo, David, additional, Graupera, Mariona, additional, Gomis, Roger R., additional, Mateo, Joaquin, additional, Unda, Miguel, additional, Gonzalez-Billalabeitia, Enrique, additional, Loizaga-Iriarte, Ana, additional, Mendizabal, Isabel, additional, and Carracedo, Arkaitz, additional

Published
2024
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7. LCOR mediates interferon-independent tumor immunogenicity and responsiveness to immune-checkpoint blockade in triple-negative breast cancer

Author

Pérez-Núñez, Iván, Rozalén, Catalina, Palomeque, José Ángel, Sangrador, Irene, Dalmau, Mariona, Comerma, Laura, Hernández-Prat, Anna, Casadevall, David, Menendez, Silvia, Liu, Daniel Dan, Shen, Minhong, Berenguer, Jordi, Ruiz, Irene Rius, Peña, Raul, Montañés, José Carlos, Albà, M. Mar, Bonnin, Sarah, Ponomarenko, Julia, Gomis, Roger R., Cejalvo, Juan Miguel, Servitja, Sonia, Marzese, Diego M., Morey, Lluis, Voorwerk, Leonie, Arribas, Joaquín, Bermejo, Begoña, Kok, Marleen, Pusztai, Lajos, Kang, Yibin, Albanell, Joan, and Celià-Terrassa, Toni

Published
2022
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8. Targeted immunotherapy against distinct cancer-associated fibroblasts overcomes treatment resistance in refractory HER2+ breast tumors

Author

Rivas, Elisa I., Linares, Jenniffer, Zwick, Melissa, Gómez-Llonin, Andrea, Guiu, Marc, Labernadie, Anna, Badia-Ramentol, Jordi, Lladó, Anna, Bardia, Lídia, Pérez-Núñez, Iván, Martínez-Ciarpaglini, Carolina, Tarazona, Noelia, Sallent-Aragay, Anna, Garrido, Marta, Celià-Terrassa, Toni, Burgués, Octavio, Gomis, Roger R., Albanell, Joan, and Calon, Alexandre

Published
2022
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9. The PP2A regulator IER5L supports prostate cancer progression.

Author

Crespo, Jana R., Martín-Martín, Natalia, Garcia-Longarte, Saioa, Corres-Mendizabal, Jon, Carlevaris, Onintza, Astobiza, Ianire, Zabala-Letona, Amaia, Guiu, Marc, Azkargorta, Mikel, Gonzalez-Lopez, Monika, Macías-Cámara, Nuria, Doan, Phuong, Elortza, Félix, Mendizabal, Isabel, Westermack, Jukka, Gomis, Roger R., Ercilla, Amaia, and Carracedo, Arkaitz

Published
2024
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12. Phenotypic changes of HER2-positive breast cancer during and after dual HER2 blockade

Author

Brasó-Maristany, Fara, Griguolo, Gaia, Pascual, Tomás, Paré, Laia, Nuciforo, Paolo, Llombart-Cussac, Antonio, Bermejo, Begoña, Oliveira, Mafalda, Morales, Serafín, Martínez, Noelia, Vidal, Maria, Adamo, Barbara, Martínez, Olga, Pernas, Sonia, López, Rafael, Muñoz, Montserrat, Chic, Núria, Galván, Patricia, Garau, Isabel, Manso, Luis, Alarcón, Jesús, Martínez, Eduardo, Gregorio, Sara, Gomis, Roger R., Villagrasa, Patricia, Cortés, Javier, Ciruelos, Eva, and Prat, Aleix

Published
2020
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13. MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer

Author

Gawrzak, Sylwia, Rinaldi, Lorenzo, Gregorio, Sara, Arenas, Enrique J., Salvador, Fernando, Urosevic, Jelena, Figueras-Puig, Cristina, Rojo, Federico, del Barco Barrantes, Ivan, Cejalvo, Juan Miguel, Palafox, Marta, Guiu, Marc, Berenguer-Llergo, Antonio, Symeonidi, Aikaterini, Bellmunt, Anna, Kalafatovic, Daniela, Arnal-Estapé, Anna, Fernández, Esther, Müllauer, Barbara, Groeneveld, Rianne, Slobodnyuk, Konstantin, Stephan-Otto Attolini, Camille, Saura, Cristina, Arribas, Joaquín, Cortes, Javier, Rovira, Ana, Muñoz, Montse, Lluch, Ana, Serra, Violeta, Albanell, Joan, Prat, Aleix, Nebreda, Angel R., Benitah, Salvador Aznar, and Gomis, Roger R.

Published
2018
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14. Suppl Table 2 from CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets

Author

Cortazar, Ana R., primary, Torrano, Veronica, primary, Martín-Martín, Natalia, primary, Caro-Maldonado, Alfredo, primary, Camacho, Laura, primary, Hermanova, Ivana, primary, Guruceaga, Elizabeth, primary, Lorenzo-Martín, Luis F., primary, Caloto, Ruben, primary, Gomis, Roger R., primary, Apaolaza, Iñigo, primary, Quesada, Victor, primary, Trka, Jan, primary, Gomez-Muñoz, Antonio, primary, Vincent, Silvestre, primary, Bustelo, Xose R., primary, Planes, Francisco J., primary, Aransay, Ana M., primary, and Carracedo, Arkaitz, primary

Published
2023
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15. Table S1 from Intrinsic Subtypes and Gene Expression Profiles in Primary and Metastatic Breast Cancer

Author

Cejalvo, Juan M., primary, Martínez de Dueñas, Eduardo, primary, Galván, Patricia, primary, García-Recio, Susana, primary, Burgués Gasión, Octavio, primary, Paré, Laia, primary, Antolín, Silvia, primary, Martinello, Rosella, primary, Blancas, Isabel, primary, Adamo, Barbara, primary, Guerrero-Zotano, Ángel, primary, Muñoz, Montserrat, primary, Nucíforo, Paolo, primary, Vidal, María, primary, Pérez, Ramón M., primary, Chacón López-Muniz, José I., primary, Caballero, Rosalía, primary, Peg, Vicente, primary, Carrasco, Eva, primary, Rojo, Federico, primary, Perou, Charles M., primary, Cortés, Javier, primary, Adamo, Vincenzo, primary, Albanell, Joan, primary, Gomis, Roger R., primary, Lluch, Ana, primary, and Prat, Aleix, primary

Published
2023
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16. Data from ERK1/2 Signaling Induces Upregulation of ANGPT2 and CXCR4 to Mediate Liver Metastasis in Colon Cancer

Author

Urosevic, Jelena, primary, Blasco, María Teresa, primary, Llorente, Alicia, primary, Bellmunt, Anna, primary, Berenguer-Llergo, Antoni, primary, Guiu, Marc, primary, Cañellas, Adrià, primary, Fernandez, Esther, primary, Burkov, Ivan, primary, Clapés, Maria, primary, Cartanà, Mireia, primary, Figueras-Puig, Cristina, primary, Batlle, Eduard, primary, Nebreda, Angel R., primary, and Gomis, Roger R., primary

Published
2023
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17. Figure S4 from Intrinsic Subtypes and Gene Expression Profiles in Primary and Metastatic Breast Cancer

Author

Cejalvo, Juan M., primary, Martínez de Dueñas, Eduardo, primary, Galván, Patricia, primary, García-Recio, Susana, primary, Burgués Gasión, Octavio, primary, Paré, Laia, primary, Antolín, Silvia, primary, Martinello, Rosella, primary, Blancas, Isabel, primary, Adamo, Barbara, primary, Guerrero-Zotano, Ángel, primary, Muñoz, Montserrat, primary, Nucíforo, Paolo, primary, Vidal, María, primary, Pérez, Ramón M., primary, Chacón López-Muniz, José I., primary, Caballero, Rosalía, primary, Peg, Vicente, primary, Carrasco, Eva, primary, Rojo, Federico, primary, Perou, Charles M., primary, Cortés, Javier, primary, Adamo, Vincenzo, primary, Albanell, Joan, primary, Gomis, Roger R., primary, Lluch, Ana, primary, and Prat, Aleix, primary

Published
2023
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18. Data from CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets

Author

Cortazar, Ana R., primary, Torrano, Veronica, primary, Martín-Martín, Natalia, primary, Caro-Maldonado, Alfredo, primary, Camacho, Laura, primary, Hermanova, Ivana, primary, Guruceaga, Elizabeth, primary, Lorenzo-Martín, Luis F., primary, Caloto, Ruben, primary, Gomis, Roger R., primary, Apaolaza, Iñigo, primary, Quesada, Victor, primary, Trka, Jan, primary, Gomez-Muñoz, Antonio, primary, Vincent, Silvestre, primary, Bustelo, Xose R., primary, Planes, Francisco J., primary, Aransay, Ana M., primary, and Carracedo, Arkaitz, primary

Published
2023
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19. Supplementary Figure legends from CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets

Author

Cortazar, Ana R., primary, Torrano, Veronica, primary, Martín-Martín, Natalia, primary, Caro-Maldonado, Alfredo, primary, Camacho, Laura, primary, Hermanova, Ivana, primary, Guruceaga, Elizabeth, primary, Lorenzo-Martín, Luis F., primary, Caloto, Ruben, primary, Gomis, Roger R., primary, Apaolaza, Iñigo, primary, Quesada, Victor, primary, Trka, Jan, primary, Gomez-Muñoz, Antonio, primary, Vincent, Silvestre, primary, Bustelo, Xose R., primary, Planes, Francisco J., primary, Aransay, Ana M., primary, and Carracedo, Arkaitz, primary

Published
2023
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20. Suppl Table 1 from CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets

Author

Cortazar, Ana R., primary, Torrano, Veronica, primary, Martín-Martín, Natalia, primary, Caro-Maldonado, Alfredo, primary, Camacho, Laura, primary, Hermanova, Ivana, primary, Guruceaga, Elizabeth, primary, Lorenzo-Martín, Luis F., primary, Caloto, Ruben, primary, Gomis, Roger R., primary, Apaolaza, Iñigo, primary, Quesada, Victor, primary, Trka, Jan, primary, Gomez-Muñoz, Antonio, primary, Vincent, Silvestre, primary, Bustelo, Xose R., primary, Planes, Francisco J., primary, Aransay, Ana M., primary, and Carracedo, Arkaitz, primary

Published
2023
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21. Data from Intrinsic Subtypes and Gene Expression Profiles in Primary and Metastatic Breast Cancer

Author

Cejalvo, Juan M., primary, Martínez de Dueñas, Eduardo, primary, Galván, Patricia, primary, García-Recio, Susana, primary, Burgués Gasión, Octavio, primary, Paré, Laia, primary, Antolín, Silvia, primary, Martinello, Rosella, primary, Blancas, Isabel, primary, Adamo, Barbara, primary, Guerrero-Zotano, Ángel, primary, Muñoz, Montserrat, primary, Nucíforo, Paolo, primary, Vidal, María, primary, Pérez, Ramón M., primary, Chacón López-Muniz, José I., primary, Caballero, Rosalía, primary, Peg, Vicente, primary, Carrasco, Eva, primary, Rojo, Federico, primary, Perou, Charles M., primary, Cortés, Javier, primary, Adamo, Vincenzo, primary, Albanell, Joan, primary, Gomis, Roger R., primary, Lluch, Ana, primary, and Prat, Aleix, primary

Published
2023
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22. Supplementary Materials and Methods from ERK1/2 Signaling Induces Upregulation of ANGPT2 and CXCR4 to Mediate Liver Metastasis in Colon Cancer

Author

Urosevic, Jelena, primary, Blasco, María Teresa, primary, Llorente, Alicia, primary, Bellmunt, Anna, primary, Berenguer-Llergo, Antoni, primary, Guiu, Marc, primary, Cañellas, Adrià, primary, Fernandez, Esther, primary, Burkov, Ivan, primary, Clapés, Maria, primary, Cartanà, Mireia, primary, Figueras-Puig, Cristina, primary, Batlle, Eduard, primary, Nebreda, Angel R., primary, and Gomis, Roger R., primary

Published
2023
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23. Supplementary figures from CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets

Author

Cortazar, Ana R., primary, Torrano, Veronica, primary, Martín-Martín, Natalia, primary, Caro-Maldonado, Alfredo, primary, Camacho, Laura, primary, Hermanova, Ivana, primary, Guruceaga, Elizabeth, primary, Lorenzo-Martín, Luis F., primary, Caloto, Ruben, primary, Gomis, Roger R., primary, Apaolaza, Iñigo, primary, Quesada, Victor, primary, Trka, Jan, primary, Gomez-Muñoz, Antonio, primary, Vincent, Silvestre, primary, Bustelo, Xose R., primary, Planes, Francisco J., primary, Aransay, Ana M., primary, and Carracedo, Arkaitz, primary

Published
2023
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24. Supplementary Figures and Tables from ERK1/2 Signaling Induces Upregulation of ANGPT2 and CXCR4 to Mediate Liver Metastasis in Colon Cancer

Author

Urosevic, Jelena, primary, Blasco, María Teresa, primary, Llorente, Alicia, primary, Bellmunt, Anna, primary, Berenguer-Llergo, Antoni, primary, Guiu, Marc, primary, Cañellas, Adrià, primary, Fernandez, Esther, primary, Burkov, Ivan, primary, Clapés, Maria, primary, Cartanà, Mireia, primary, Figueras-Puig, Cristina, primary, Batlle, Eduard, primary, Nebreda, Angel R., primary, and Gomis, Roger R., primary

Published
2023
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25. Supplementary Figure 1 from Constitutive HER2 Signaling Promotes Breast Cancer Metastasis through Cellular Senescence

Author

Angelini, Pier Davide, primary, Fluck, Mariano F. Zacarias, primary, Pedersen, Kim, primary, Parra-Palau, Josep Lluís, primary, Guiu, Marc, primary, Bernadó Morales, Cristina, primary, Vicario, Rocio, primary, Luque-García, Antonio, primary, Navalpotro, Nerea Peiró, primary, Giralt, Jordi, primary, Canals, Francesc, primary, Gomis, Roger R., primary, Tabernero, Josep, primary, Baselga, José, primary, Villanueva, Josep, primary, and Arribas, Joaquín, primary

Published
2023
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26. Supplementary Figure 4 from Constitutive HER2 Signaling Promotes Breast Cancer Metastasis through Cellular Senescence

Author

Angelini, Pier Davide, primary, Fluck, Mariano F. Zacarias, primary, Pedersen, Kim, primary, Parra-Palau, Josep Lluís, primary, Guiu, Marc, primary, Bernadó Morales, Cristina, primary, Vicario, Rocio, primary, Luque-García, Antonio, primary, Navalpotro, Nerea Peiró, primary, Giralt, Jordi, primary, Canals, Francesc, primary, Gomis, Roger R., primary, Tabernero, Josep, primary, Baselga, José, primary, Villanueva, Josep, primary, and Arribas, Joaquín, primary

Published
2023
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27. Supplementary Figure 2 from Constitutive HER2 Signaling Promotes Breast Cancer Metastasis through Cellular Senescence

Author

Angelini, Pier Davide, primary, Fluck, Mariano F. Zacarias, primary, Pedersen, Kim, primary, Parra-Palau, Josep Lluís, primary, Guiu, Marc, primary, Bernadó Morales, Cristina, primary, Vicario, Rocio, primary, Luque-García, Antonio, primary, Navalpotro, Nerea Peiró, primary, Giralt, Jordi, primary, Canals, Francesc, primary, Gomis, Roger R., primary, Tabernero, Josep, primary, Baselga, José, primary, Villanueva, Josep, primary, and Arribas, Joaquín, primary

Published
2023
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28. Supplementary Tables 1 - 3 from Constitutive HER2 Signaling Promotes Breast Cancer Metastasis through Cellular Senescence

Author

Angelini, Pier Davide, primary, Fluck, Mariano F. Zacarias, primary, Pedersen, Kim, primary, Parra-Palau, Josep Lluís, primary, Guiu, Marc, primary, Bernadó Morales, Cristina, primary, Vicario, Rocio, primary, Luque-García, Antonio, primary, Navalpotro, Nerea Peiró, primary, Giralt, Jordi, primary, Canals, Francesc, primary, Gomis, Roger R., primary, Tabernero, Josep, primary, Baselga, José, primary, Villanueva, Josep, primary, and Arribas, Joaquín, primary

Published
2023
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29. Supplementary Figure 5 from Constitutive HER2 Signaling Promotes Breast Cancer Metastasis through Cellular Senescence

Author

Angelini, Pier Davide, primary, Fluck, Mariano F. Zacarias, primary, Pedersen, Kim, primary, Parra-Palau, Josep Lluís, primary, Guiu, Marc, primary, Bernadó Morales, Cristina, primary, Vicario, Rocio, primary, Luque-García, Antonio, primary, Navalpotro, Nerea Peiró, primary, Giralt, Jordi, primary, Canals, Francesc, primary, Gomis, Roger R., primary, Tabernero, Josep, primary, Baselga, José, primary, Villanueva, Josep, primary, and Arribas, Joaquín, primary

Published
2023
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30. Supplementary Figure Legends 1-6 from Constitutive HER2 Signaling Promotes Breast Cancer Metastasis through Cellular Senescence

Author

Angelini, Pier Davide, primary, Fluck, Mariano F. Zacarias, primary, Pedersen, Kim, primary, Parra-Palau, Josep Lluís, primary, Guiu, Marc, primary, Bernadó Morales, Cristina, primary, Vicario, Rocio, primary, Luque-García, Antonio, primary, Navalpotro, Nerea Peiró, primary, Giralt, Jordi, primary, Canals, Francesc, primary, Gomis, Roger R., primary, Tabernero, Josep, primary, Baselga, José, primary, Villanueva, Josep, primary, and Arribas, Joaquín, primary

Published
2023
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31. Supplementary Figure 6 from Constitutive HER2 Signaling Promotes Breast Cancer Metastasis through Cellular Senescence

Author

Angelini, Pier Davide, primary, Fluck, Mariano F. Zacarias, primary, Pedersen, Kim, primary, Parra-Palau, Josep Lluís, primary, Guiu, Marc, primary, Bernadó Morales, Cristina, primary, Vicario, Rocio, primary, Luque-García, Antonio, primary, Navalpotro, Nerea Peiró, primary, Giralt, Jordi, primary, Canals, Francesc, primary, Gomis, Roger R., primary, Tabernero, Josep, primary, Baselga, José, primary, Villanueva, Josep, primary, and Arribas, Joaquín, primary

Published
2023
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33. Data from Constitutive HER2 Signaling Promotes Breast Cancer Metastasis through Cellular Senescence

Author

Angelini, Pier Davide, primary, Fluck, Mariano F. Zacarias, primary, Pedersen, Kim, primary, Parra-Palau, Josep Lluís, primary, Guiu, Marc, primary, Bernadó Morales, Cristina, primary, Vicario, Rocio, primary, Luque-García, Antonio, primary, Navalpotro, Nerea Peiró, primary, Giralt, Jordi, primary, Canals, Francesc, primary, Gomis, Roger R., primary, Tabernero, Josep, primary, Baselga, José, primary, Villanueva, Josep, primary, and Arribas, Joaquín, primary

Published
2023
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34. Supplementary Figure 3 from Constitutive HER2 Signaling Promotes Breast Cancer Metastasis through Cellular Senescence

Author

Angelini, Pier Davide, primary, Fluck, Mariano F. Zacarias, primary, Pedersen, Kim, primary, Parra-Palau, Josep Lluís, primary, Guiu, Marc, primary, Bernadó Morales, Cristina, primary, Vicario, Rocio, primary, Luque-García, Antonio, primary, Navalpotro, Nerea Peiró, primary, Giralt, Jordi, primary, Canals, Francesc, primary, Gomis, Roger R., primary, Tabernero, Josep, primary, Baselga, José, primary, Villanueva, Josep, primary, and Arribas, Joaquín, primary

Published
2023
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36. Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy

Author

Fundación Científica Asociación Española Contra el Cáncer, Instituto de Salud Carlos III, European Commission, Ministerio de Economía y Competitividad (España), Fundación la Caixa, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Linares, Jenniffer, Sallent-Aragay, Anna, Badia-Ramentol, Jordi, Recort-Bascuas, Alba, Méndez, Ana, Manero-Rupérez, Noemí, Re, Daniele Lo, Rivas, Elisa I., Guiu, Marc, Zwick, Melissa, Iglesias, Mar, Martinez-Ciarpaglini, Carolina, Tarazona, Noelia, Varese, Monica, Hernando-Momblona, Xavier, Cañellas-Socias, Adrià, Orriols, Mayra, Garrido, Marta, Saoudi, Nadia, Elez, Elena, Navarro Medrano, Pilar, Tabernero, Josep, Gomis, Roger R., Batlle, Eduard, Pisonero, Jorge, Cervantes, Andrés, Montagut, Clara, Calon, Alexandre, Fundación Científica Asociación Española Contra el Cáncer, Instituto de Salud Carlos III, European Commission, Ministerio de Economía y Competitividad (España), Fundación la Caixa, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Linares, Jenniffer, Sallent-Aragay, Anna, Badia-Ramentol, Jordi, Recort-Bascuas, Alba, Méndez, Ana, Manero-Rupérez, Noemí, Re, Daniele Lo, Rivas, Elisa I., Guiu, Marc, Zwick, Melissa, Iglesias, Mar, Martinez-Ciarpaglini, Carolina, Tarazona, Noelia, Varese, Monica, Hernando-Momblona, Xavier, Cañellas-Socias, Adrià, Orriols, Mayra, Garrido, Marta, Saoudi, Nadia, Elez, Elena, Navarro Medrano, Pilar, Tabernero, Josep, Gomis, Roger R., Batlle, Eduard, Pisonero, Jorge, Cervantes, Andrés, Montagut, Clara, and Calon, Alexandre

Abstract

A substantial proportion of cancer patients do not benefit from platinum-based chemotherapy (CT) due to the emergence of drug resistance. Here, we apply elemental imaging to the mapping of CT biodistribution after therapy in residual colorectal cancer and achieve a comprehensive analysis of the genetic program induced by oxaliplatin-based CT in the tumor microenvironment. We show that oxaliplatin is largely retained by cancer-associated fibroblasts (CAFs) long time after the treatment ceased. We determine that CT accumulation in CAFs intensifies TGF-beta activity, leading to the production of multiple factors enhancing cancer aggressiveness. We establish periostin as a stromal marker of chemotherapeutic activity intrinsically upregulated in consensus molecular subtype 4 (CMS4) tumors and highly expressed before and/or after treatment in patients unresponsive to therapy. Collectively, our study underscores the ability of CT-retaining CAFs to support cancer progression and resistance to treatment.

Published
2023

37. MAFamplification licenses ERα through epigenetic remodelling to drive breast cancer metastasis

Author

Llorente, Alicia, Blasco, María Teresa, Espuny, Irene, Guiu, Marc, Ballaré, Cecilia, Blanco, Enrique, Caballé, Adrià, Bellmunt, Anna, Salvador, Fernando, Morales, Andrea, Nuñez, Marc, Loren, Guillem, Imbastari, Francesca, Fidalgo, Marta, Figueras-Puig, Cristina, Gibler, Patrizia, Graupera, Mariona, Monteiro, Freddy, Riera, Antoni, Holen, Ingunn, Avgustinova, Alexandra, Di Croce, Luciano, and Gomis, Roger R.

Abstract

MAFamplification increases the risk of breast cancer (BCa) metastasis through mechanisms that are still poorly understood yet have important clinical implications. Oestrogen-receptor-positive (ER+) BCa requires oestrogen for both growth and metastasis, albeit by ill-known mechanisms. Here we integrate proteomics, transcriptomics, epigenomics, chromatin accessibility and functional assays from human and syngeneic mouse BCa models to show that MAF directly interacts with oestrogen receptor alpha (ERα), thereby promoting a unique chromatin landscape that favours metastatic spread. We identify metastasis-promoting genes that are de novo licensed following oestrogen exposure in a MAF-dependent manner. The histone demethylase KDM1A is key to the epigenomic remodelling that facilitates the expression of the pro-metastatic MAF/oestrogen-driven gene expression program, and loss of KDM1A activity prevents this metastasis. We have thus determined that the molecular basis underlying MAF/oestrogen-mediated metastasis requires genetic, epigenetic and hormone signals from the systemic environment, which influence the ability of BCa cells to metastasize.

Published
2023
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40. The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

Author

Torrano, Veronica, Valcarcel-Jimenez, Lorea, Cortazar, Ana Rosa, Liu, Xiaojing, Urosevic, Jelena, Castillo-Martin, Mireia, Fernández-Ruiz, Sonia, Morciano, Giampaolo, Caro-Maldonado, Alfredo, Guiu, Marc, Zúñiga-García, Patricia, Graupera, Mariona, Bellmunt, Anna, Pandya, Pahini, Lorente, Mar, Martín-Martín, Natalia, Sutherland, James David, Sanchez-Mosquera, Pilar, Bozal-Basterra, Laura, Zabala-Letona, Amaia, Arruabarrena-Aristorena, Amaia, Berenguer, Antonio, Embade, Nieves, Ugalde-Olano, Aitziber, Lacasa-Viscasillas, Isabel, Loizaga-Iriarte, Ana, Unda-Urzaiz, Miguel, Schultz, Nikolaus, Aransay, Ana Maria, Sanz-Moreno, Victoria, Barrio, Rosa, Velasco, Guillermo, Pinton, Paolo, Cordon-Cardo, Carlos, Locasale, Jason W., Gomis, Roger R., and Carracedo, Arkaitz

Published
2016
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41. Enhanced MAF Oncogene Expression and Breast Cancer Bone Metastasis

Author

Pavlovic, Milica, Arnal-Estapé, Anna, Rojo, Federico, Bellmunt, Anna, Tarragona, Maria, Guiu, Marc, Planet, Evarist, Garcia-Albéniz, Xabier, Morales, Mónica, Urosevic, Jelena, Gawrzak, Sylwia, Rovira, Ana, Prat, Aleix, Nonell, Lara, Lluch, Ana, Jean-Mairet, Joël, Coleman, Robert, Albanell, Joan, and Gomis, Roger R.

Published
2015
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42. Paper-based biosensors for cancer diagnostics

Author

Agencia Estatal de Investigación (España), Generalitat de Catalunya, European Commission, Fundação para a Ciência e a Tecnologia (Portugal), Pereira, Cláudia F., Parolo, Claudio, Idili, Andrea, Gomis, Roger R., Rodrigues, Lígia, Sales, Goreti, Merkoçi, Arben, Agencia Estatal de Investigación (España), Generalitat de Catalunya, European Commission, Fundação para a Ciência e a Tecnologia (Portugal), Pereira, Cláudia F., Parolo, Claudio, Idili, Andrea, Gomis, Roger R., Rodrigues, Lígia, Sales, Goreti, and Merkoçi, Arben

Abstract

The implementation of a wide diagnostic campaign to diagnose cancer early could save millions of lives and billions of dollars every year. Unfortunately, cancer diagnosis is extremely complicated and current approaches rely on the use of expensive equipment and specialized personnel, which hamper their deployment in low- and middle-income settings. Here, we analyze the technical challenges that must be overcome to achieve precise cancer diagnostics and we describe how such hurdles have limited the development of point-of-care (PoC) sensors. Then, we explain why we believe recent achievements in the field of paper-based sensors could allow their use as widely available sensing platforms for cancer detection. Finally, we present our vision of what should be done in order to make paper-based sensors widely used diagnostics platforms for cancer.

Published
2022

49. Loss of microRNA-135b Enhances Bone Metastasis in Prostate Cancer and Predicts Aggressiveness in Human Prostate Samples

Author

Olivan, Mireia, primary, Garcia, Marta, additional, Suárez, Leticia, additional, Guiu, Marc, additional, Gros, Laura, additional, Méndez, Olga, additional, Rigau, Marina, additional, Reventós, Jaume, additional, Segura, Miguel F., additional, de Torres, Inés, additional, Planas, Jacques, additional, de la Cruz, Xavier, additional, Gomis, Roger R., additional, Morote, Juan, additional, Rodríguez-Barrueco, Ruth, additional, and Santamaria, Anna, additional

Published
2021
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