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16 results on '"Gomez-Valdes, Jorge"'

1. Paleogenomic insights into the red complex bacteria Tannerella forsythia in Pre-Hispanic and Colonial individuals from Mexico

Author

Bravo-Lopez, Miriam, Villa-Islas, Viridiana, Arriaga, Carolina Rocha, Villaseñor-Altamirano, Ana B., Guzmán-Solís, Axel, Sandoval-Velasco, Marcela, Wesp, Julie K., Alcantara, Keitlyn, López-Corral, Aurelio, Gómez-Valdés, Jorge, Mejía, Elizabeth, Herrera, Alberto, Meraz-Moreno, Alejandro, de la Luz Moreno-Cabrera, Maria, Moreno-Estrada, Andrés, Nieves-Colón, Maria A., Olvera, Joel, Pérez-Pérez, Julia, Iversen, Katrine Højholt, Rasmussen, Simon, Sandoval, Karla, Zepeda, Gabriela, and Ávila-Arcos, María C.

Published
2020

2. Prediction of eye, hair and skin colour in Latin Americans

Author

Palmal, Sagnik, Adhikari, Kaustubh, Mendoza-Revilla, Javier, Fuentes-Guajardo, Macarena, Silva de Cerqueira, Caio Cesar, Bonfante, Betty, Chacón-Duque, Juan Camilo, Sohail, Anood, Hurtado, Malena, Villegas, Valeria, Granja, Vanessa, Jaramillo, Claudia, Arias, William, Lozano, Rodrigo Barquera, Everardo-Martínez, Paola, Gómez-Valdés, Jorge, Villamil-Ramírez, Hugo, Hünemeier, Tábita, Ramallo, Virginia, Parolin, Maria-Laura, Gonzalez-José, Rolando, Schüler-Faccini, Lavinia, Bortolini, Maria-Cátira, Acuña-Alonzo, Victor, Canizales-Quinteros, Samuel, Gallo, Carla, Poletti, Giovanni, Bedoya, Gabriel, Rothhammer, Francisco, Balding, David, Faux, Pierre, and Ruiz-Linares, Andrés

Published
2021
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7. Neanderthal introgression in SCN9A impacts mechanical pain sensitivity

Author

Faux, Pierre, Ding, Li, Miguel Ramirez-Aristeguieta, Luis, Chacón-Duque, J. Camilo, Comini, Maddalena, Mendoza-Revilla, Javier, Fuentes-Guajardo, Macarena, Jaramillo, Claudia, Arias, William, Hurtado, Malena, Villegas, Valeria, Granja, Vanessa, Barquera, Rodrigo, Everardo-Martinez, Paola, Quinto-Sanchez, Mirsha, Gomez-Valdes, Jorge, Villamil-Ramirez, Hugo, Silva de Cerqueira, Caio C., Hunemeier, Tabita, Ramallo, Virginia, Gonzalez-Jose, Rolando, Schuler-Faccini, Lavinia, Bortolini, Maria-Catira, Acuna-Alonzo, Victor, Canizales-Quinteros, Samuel, Poletti, Giovanni, Gallo, Carla, Rothhammer, Francisco, Rojas, Winston, Schmid, Annina B., Adhikari, Kaustubh, Bennett, David L., Ruiz-Linares, Andres, Faux, Pierre, Ding, Li, Miguel Ramirez-Aristeguieta, Luis, Chacón-Duque, J. Camilo, Comini, Maddalena, Mendoza-Revilla, Javier, Fuentes-Guajardo, Macarena, Jaramillo, Claudia, Arias, William, Hurtado, Malena, Villegas, Valeria, Granja, Vanessa, Barquera, Rodrigo, Everardo-Martinez, Paola, Quinto-Sanchez, Mirsha, Gomez-Valdes, Jorge, Villamil-Ramirez, Hugo, Silva de Cerqueira, Caio C., Hunemeier, Tabita, Ramallo, Virginia, Gonzalez-Jose, Rolando, Schuler-Faccini, Lavinia, Bortolini, Maria-Catira, Acuna-Alonzo, Victor, Canizales-Quinteros, Samuel, Poletti, Giovanni, Gallo, Carla, Rothhammer, Francisco, Rojas, Winston, Schmid, Annina B., Adhikari, Kaustubh, Bennett, David L., and Ruiz-Linares, Andres

Abstract

The Nav1.7 voltage-gated sodium channel plays a key role in nociception. Three functional variants in the SCN9A gene (encoding M932L, V991L, and D1908G in Nav1.7), have recently been identified as stemming from Neanderthal introgression and to associate with pain symptomatology in UK BioBank data. In 1000 genomes data, these variants are absent in Europeans but common in Latin Americans. Analysing high-density genotype data from 7594 Latin Americans, we characterized Neanderthal introgression in SCN9A. We find that tracts of introgression occur on a Native American genomic background, have an average length of similar to 123kb and overlap the M932L, V991L, and D1908G coding positions. Furthermore, we measured experimentally six pain thresholds in 1623 healthy Colombians. We found that Neanderthal ancestry in SCN9A is significantly associated with a lower mechanical pain threshold after sensitization with mustard oil and evidence of additivity of effects across Nav1.7 variants. Our findings support the reported association of Neanderthal Nav1.7 variants with clinical pain, define a specific sensory modality affected by archaic introgression in SCN9A and are consistent with independent effects of the Neanderthal variants on Nav1.7 function. Neanderthal-derived variants in the SCN9A gene (encoding the voltage gated sodium channel, Nav1.7) are associated with enhanced experimental mechanical pain sensitivity in modern humans.

Published
2023
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12. Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face

Author

Quinto-Sánchez, Mirsha, primary, Muñoz-Muñoz, Francesc, additional, Gomez-Valdes, Jorge, additional, Cintas, Celia, additional, Navarro, Pablo, additional, Cerqueira, Caio Cesar Silva de, additional, Paschetta, Carolina, additional, de Azevedo, Soledad, additional, Ramallo, Virginia, additional, Acuña-Alonzo, Victor, additional, Adhikari, Kaustubh, additional, Fuentes-Guajardo, Macarena, additional, Hünemeier, Tábita, additional, Everardo, Paola, additional, de Avila, Francisco, additional, Jaramillo, Claudia, additional, Arias, Williams, additional, Gallo, Carla, additional, Poletti, Giovani, additional, Bedoya, Gabriel, additional, Bortolini, Maria Cátira, additional, Canizales-Quinteros, Samuel, additional, Rothhammer, Francisco, additional, Rosique, Javier, additional, Ruiz-Linares, Andres, additional, and Gonzalez-Jose, Rolando, additional

Published
2018
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13. Evaluación del sesgo en las clasificaciones taxonómicas del índice cefálico

Author

Gomez Valdes, Jorge A. and Quinto Sanchez, Mirsha Emmanuel

Subjects
purl.org/becyt/ford/1 [https], SESGO, TAXONOMIA, Ciencias Biológicas, INDICE CEFÁLICO, MORFOMETRÍA CLÁSICA, Otras Ciencias Biológicas, purl.org/becyt/ford/1.6 [https], ANTROPOMETRIA, CIENCIAS NATURALES Y EXACTAS
Abstract

El índice cefálico (ic) ha sido ampliamente utilizado para establecer categorías taxonómicas humanas. Aunque su significado biológico ha sido discutido, pocos trabajos han analizado la relación numérica del índice y sus clasificaciones. Aquí se aborda uno de los sesgos introducidos por la transformación en categorías de clase (braquicefalia, mesocefalia y dolicocefalia) de la distribución continua del ic, se analiza el efecto que tiene en la varianza poblacional y en la densidad de los datos. Por medio de la Howells World Data Set recurrimos al coeficiente de determinación como estimador de la cantidad de información que se conserva posterior a la trans- formación categórica del ic. Nuestros resultados indican que las clasificaciones del ic son un reducto de la variabilidad biológica craneal de las poblaciones humanas. La adopción de modelos no lineales hiperdimensionales y multivariados representa un mejor acercamiento a la covariación de las formas biológicas. The cephalic index (ic) has been widely used as one of the higher profile tools to establish human taxonomy categories. Although it has been discussed the biological sense of the cephalic index, few studies analyzed the mathematics relations of the ratio and their classifications. In this paper, we address one of the biases introduced by the transformation into class categories (brachycephaly, mesocephaly and dolichocephaly) of the continuous distribution of IC, analyzing the effect in the population variance and the density of the data. Thus, we used Howells World Data Set for determination coefficient as an estimate of amount of information retained after processing IC categories. Our results indicate that the ratings of the IC are a haven of cranial biological variability of human populations. The adoption of hyperdimensional non-linear and multivariate models represents a better approach to the covariance of biological forms. Fil: Gomez Valdes, Jorge A.. Universidad Nacional Autónoma de México; México Fil: Quinto Sanchez, Mirsha Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina

Published
2013

14. Fibroblast Growth Factor Receptor 1 Variants and Craniofacial Variation in Amerindians and Related Populations

Author

Gomez Valdes, Jorge, Hünemeier, Tábita, Contini, Verónica, Acuña Alonzo, Victor, Macin, Gastón, Ballesteros Romero, Mónica, Corral, Pau, Ruiz Linares, Andres, Sanchez Mejorada, Gabriela, Canizales Quinteros, Samuel, Martínez Abadías, Neus, Salzano, Francisco M., Gonzalez Jose, Rolando, and Bortolini, Maria Catira

Subjects
Ciencias Biológicas, Genética y Herencia, FIBROBLAST GROWTH FACTOR RECEPTOR GENE, NATIVE AMERICANS, CEPHALIC INDEX, RANIOFACIAL DEVELOPMENT, MEXICAN POPULATIONS, CIENCIAS NATURALES Y EXACTAS
Abstract

Objectives: The polymorphic site rs4647905 of the FGFR1 gene was previously associated with a decrease in cephalic index (CI). Here, we evaluate the relationships between genotypes and cephalometric measurements and indices in one Mexican Native and two mestizo Mexican populations using two haplotype-tag SNPs (rs4647905 and rs3213849) that represent >85% of the FGFR1 variability, plus three other SNPs (rs2293971, rs2304000, and rs930828) situated nearby. In addition, we genotyped five South American natives, two European, one African, and one Siberian populations to evaluate their intra and intercontinental population diversity. Methods: The five SNPs were tested and the craniofacial measurements and indices were collected using standardized procedures. Principal Component Analysis was used to verify individual/population comparisons. Associations were performed through the generalized linear model (GLM), coefficient of determination R2 and linear regression tests. Results: We found a tendency for a decrease in CI in individuals homozygous for allele rs4647905C, regardless of the population to which they belong, though the effect is more pronounced in mestizo. When the GLM analyses were performed using the absolute/linear cephalometric measurements, a statistically significant association was found between four SNPs and head length in the mestizo population. Conclusions: FGFR1 polymorphisms, especially rs4647905, can have an important role in the normal human skull variation, primarily due to their influence in head length, which would affect other cephalometric absolute/linear measures as well as indices like CI as a result of the pervasive nature of the morphological integration that characterizes the human skull. Fil: Gomez Valdes, Jorge. Universidad Nacional Autónoma de México. Facultad de Medicina. Departamento de Anatomía. Laboratorio de Antropología Física; México Fil: Hünemeier, Tábita. Universidade Federal do Rio Grande do Sul; Brasil Fil: Contini, Verónica. Universidade Federal do Rio Grande do Sul; Brasil Fil: Acuña Alonzo, Victor. Instituto Nacional de Antropologia E Historia; México. Instituto Nacional de Medicina Genómica; México Fil: Macin, Gastón. Instituto Nacional de Antropologia E Historia; México Fil: Ballesteros Romero, Mónica. Instituto Nacional de Antropologia E Historia; México Fil: Corral, Pau. Universitat Pompeu Fabra; España Fil: Ruiz Linares, Andres . University College London; Estados Unidos Fil: Sanchez Mejorada, Gabriela. Universidad Nacional Autónoma de México. Facultad de Medicina. Departamento de Anatomía. Laboratorio de Antropología Física; México Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México. Facultad de Medicina. Departamento de Anatomía. Laboratorio de Antropología Física; México. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán; México Fil: Martínez Abadías, Neus . Centre de Regulació Genòmica; España Fil: Salzano, Francisco M.. Universidade Federal do Rio Grande do Sul; Brasil Fil: Gonzalez Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina Fil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; Brasil

Published
2013
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15. Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face

Author

Quinto-Sánchez, Mirsha, Muñoz-Muñoz, Francesc, Gomez-Valdes, Jorge, Cintas, Celia, Navarro, Pablo, Cerqueira, Caio Cesar Silva de, Paschetta, Carolina, de Azevedo, Soledad, Ramallo, Virginia, Acuña-Alonzo, Victor, Adhikari, Kaustubh, Fuentes-Guajardo, Macarena, Hünemeier, Tábita, Everardo, Paola, de Avila, Francisco, Jaramillo, Claudia, Arias, Williams, Gallo, Carla, Poletti, Giovani, Bedoya, Gabriel, Bortolini, Maria Cátira, Canizales-Quinteros, Samuel, Rothhammer, Francisco, Rosique, Javier, Ruiz-Linares, Andres, Gonzalez-Jose, Rolando, Quinto-Sánchez, Mirsha, Muñoz-Muñoz, Francesc, Gomez-Valdes, Jorge, Cintas, Celia, Navarro, Pablo, Cerqueira, Caio Cesar Silva de, Paschetta, Carolina, de Azevedo, Soledad, Ramallo, Virginia, Acuña-Alonzo, Victor, Adhikari, Kaustubh, Fuentes-Guajardo, Macarena, Hünemeier, Tábita, Everardo, Paola, de Avila, Francisco, Jaramillo, Claudia, Arias, Williams, Gallo, Carla, Poletti, Giovani, Bedoya, Gabriel, Bortolini, Maria Cátira, Canizales-Quinteros, Samuel, Rothhammer, Francisco, Rosique, Javier, Ruiz-Linares, Andres, and Gonzalez-Jose, Rolando

Abstract

Facial asymmetries are usually measured and interpreted as proxies to developmental noise. However, analyses focused on its developmental and genetic architecture are scarce. To advance on this topic, studies based on a comprehensive and simultaneous analysis of modularity, morphological integration and facial asymmetries including both phenotypic and genomic information are needed. Here we explore several modularity hypotheses on a sample of Latin American mestizos, in order to test if modularity and integration patterns difer across several genomic ancestry backgrounds. To do so, 4104 individuals were analyzed using 3D photogrammetry reconstructions and a set of 34 facial landmarks placed on each individual. We found a pattern of modularity and integration that is conserved across sub-samples difering in their genomic ancestry background. Specifcally, a signal of modularity based on functional demands and organization of the face is regularly observed across the whole sample. Our results shed more light on previous evidence obtained from Genome Wide Association Studies performed on the same samples, indicating the action of diferent genomic regions contributing to the expression of the nose and mouth facial phenotypes. Our results also indicate that large samples including phenotypic and genomic metadata enable a better understanding of the developmental and genetic architecture of craniofacial phenotypes.

16. Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face

Author

Quinto-Sánchez, Mirsha, Muñoz-Muñoz, Francesc, Gomez-Valdes, Jorge, Cintas, Celia, Navarro, Pablo, Cerqueira, Caio Cesar Silva de, Paschetta, Carolina, de Azevedo, Soledad, Ramallo, Virginia, Acuña-Alonzo, Victor, Adhikari, Kaustubh, Fuentes-Guajardo, Macarena, Hünemeier, Tábita, Everardo, Paola, de Avila, Francisco, Jaramillo, Claudia, Arias, Williams, Gallo, Carla, Poletti, Giovani, Bedoya, Gabriel, Bortolini, Maria Cátira, Canizales-Quinteros, Samuel, Rothhammer, Francisco, Rosique, Javier, Ruiz-Linares, Andres, Gonzalez-Jose, Rolando, Quinto-Sánchez, Mirsha, Muñoz-Muñoz, Francesc, Gomez-Valdes, Jorge, Cintas, Celia, Navarro, Pablo, Cerqueira, Caio Cesar Silva de, Paschetta, Carolina, de Azevedo, Soledad, Ramallo, Virginia, Acuña-Alonzo, Victor, Adhikari, Kaustubh, Fuentes-Guajardo, Macarena, Hünemeier, Tábita, Everardo, Paola, de Avila, Francisco, Jaramillo, Claudia, Arias, Williams, Gallo, Carla, Poletti, Giovani, Bedoya, Gabriel, Bortolini, Maria Cátira, Canizales-Quinteros, Samuel, Rothhammer, Francisco, Rosique, Javier, Ruiz-Linares, Andres, and Gonzalez-Jose, Rolando

Abstract

Facial asymmetries are usually measured and interpreted as proxies to developmental noise. However, analyses focused on its developmental and genetic architecture are scarce. To advance on this topic, studies based on a comprehensive and simultaneous analysis of modularity, morphological integration and facial asymmetries including both phenotypic and genomic information are needed. Here we explore several modularity hypotheses on a sample of Latin American mestizos, in order to test if modularity and integration patterns difer across several genomic ancestry backgrounds. To do so, 4104 individuals were analyzed using 3D photogrammetry reconstructions and a set of 34 facial landmarks placed on each individual. We found a pattern of modularity and integration that is conserved across sub-samples difering in their genomic ancestry background. Specifcally, a signal of modularity based on functional demands and organization of the face is regularly observed across the whole sample. Our results shed more light on previous evidence obtained from Genome Wide Association Studies performed on the same samples, indicating the action of diferent genomic regions contributing to the expression of the nose and mouth facial phenotypes. Our results also indicate that large samples including phenotypic and genomic metadata enable a better understanding of the developmental and genetic architecture of craniofacial phenotypes.

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